• 3384 Citations
  • 31 Scopus h-Index
19962019

Research output per year

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Research Output

Article

A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy

Khurana, R., Ionescu-Zanetti, C., Pope, M., Li, J., Nielson, L., Ramirez-Alvarado, M., Regan, L., Fink, A. L. & Carter, S. A., Aug 1 2003, In : Biophysical Journal. 85, 2, p. 1135-1144 10 p.

Research output: Contribution to journalArticle

Open Access
234 Scopus citations

Altered dimer interface decreases stability in an amyloidogenic protein

Baden, E. M., Owen, B. A. L., Peterson, F. C., Volkman, B. F., Ramirez-Alvarado, M. & Thompson, J. R., Jun 6 2008, In : Journal of Biological Chemistry. 283, 23, p. 15853-15860 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Alzheimer's disease amyloid β-protein mutations and deletions that define neuronal binding/internalization as early stage nonfibrillar/fibrillar aggregates and late stage fibrils

Poduslo, J. F., Howell, K. G., Olson, N. C., Ramirez-Alvarado, M. & Kandimalla, K. K., May 15 2012, In : Biochemistry. 51, 19, p. 3993-4003 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Amyloid formation in light chain amyloidosis

Ramirez-Alvarado, M., Dec 1 2012, In : Current Topics in Medicinal Chemistry. 12, 22, p. 2523-2533 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL)

Abraham, R. S., Geyer, S. M., Ramírez-Alvarado, M., Price-Troska, T. L., Gertz, M. A. & Fonseca, R., Jul 1 2004, In : Journal of Clinical Immunology. 24, 4, p. 340-353 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

A reappraisal of immunoglobulin variable gene primers and its impact on assessing clonal relationships between PB B cells and BM plasma cells in AL amyloidosis

Katoh, N., Poshusta, T. L., Manske, M. K., Dispenzieri, A., Gertz, M. A., Abraham, R. S. & Ramirez-Alvarado, M., Dec 1 2011, In : Journal of Clinical Immunology. 31, 6, p. 1029-1037 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface

Peterson, F. C., Baden, E. M., Owen, B. A. L., Volkman, B. F. & Ramirez-Alvarado, M., May 1 2010, In : Structure. 18, 5, p. 563-570 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Assay to rapidly screen for immunoglobulin light chain glycosylation: a potential path to earlier AL diagnosis for a subset of patients

Kumar, S., Murray, D., Dasari, S., Milani, P., Barnidge, D., Madden, B., Kourelis, T., Arendt, B., Merlini, G., Ramirez-Alvarado, M. & Dispenzieri, A., Jul 6 2018, (Accepted/In press) In : Leukemia. p. 1-4 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Assessment of renal response with urinary exosomes in patients with AL amyloidosis: A proof of concept

Ramirez-Alvarado, M., Barnidge, D. R., Murray, D. L., Dispenzieri, A., Marin-Argany, M., Dick, C. J., Cooper, S. A., Nasr, S. H., Ward, C. J., Dasari, S., Jiménez-Zepeda, V. H. & Leung, N., Jun 1 2017, In : American Journal of Hematology. 92, 6, p. 536-541 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
175 Scopus citations

A twisted four-sheeted model for an amyloid fibril

Wang, J., Gülich, S., Bradford, C., Ramirez-Alvarado, M. & Regan, L., Sep 1 2005, In : Structure. 13, 9, p. 1279-1288 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Biochemical and aggregation analysis of Bence Jones proteins from different light chain diseases

Sikkink, L. A. & Ramirez-Alvarado, M., Feb 18 2008, In : Amyloid. 15, 1, p. 29-39 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2

Arendt, B. K., Ramirez-Alvarado, M., Sikkink, L. A., Keats, J. J., Ahmann, G. J., Dispenzieri, A., Fonseca, R., Ketterling, R. P., Knudson, R. A., Mulvihill, E. M., Tschumper, R. C., Wu, X., Zeldenrust, S. R. & Jelinek, D. F., Sep 1 2008, In : Blood. 112, 5, p. 1931-1941 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease

Holditch, S. J., Schreiber, C. A., Harris, P. C., La Russo, N. F., Ramirez-Alvarado, M., Cataliotti, A., Torres, V. & Ikeda, Y. H., Jul 22 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

4 Scopus citations

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y. P., Bren, G. D., Cummins, N. W., Correia, C., Meng, X. W., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., Jan 1 2014, In : Journal of Cell Biology. 206, 7, p. 867-876 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the co-chaperone p23

Chadli, A., Felts, S. J., Wang, Q., Sullivan, W. P., Botuyan, M. V., Fauq, A., Ramirez-Alvarado, M. & Mer, G., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 4224-4231 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Cell damage in light chain amyloidosis fibril internalization, toxicity and cell-mediated seeding

Marin-Argany, M., Lin, Y., Misra, P., Williams, A., Wall, J. S., Howell, K. G., Elsbernd, L. R., McClure, M. & Ramirez-Alvarado, M., Sep 16 2016, In : Journal of Biological Chemistry. 291, 38, p. 19813-19825 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Clarifying immunoglobulin gene usage in systemic and localized immunoglobulin light-chain amyloidosis by mass spectrometry

Kourelis, T., Dasari, S., Theis, J. D., Ramirez-Alvarado, M., Kurtin, P. J., Gertz, M., Zeldenrust, S. R., Zenka, R. M., Dogan, A. & Dispenzieri, A., Jan 19 2017, In : Blood. 129, 3, p. 299-306 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Clinical features, laboratory characteristics and outcomes of patients with renal versus cardiac light chain amyloidosis

Sidana, S., Tandon, N., Gertz, M., Dispenzieri, A., Ramirez-Alvarado, M., Murray, D. L., Kourelis, T., Buadi, F. K., Kapoor, P., Gonsalves, W., Warsame, R., Lacy, M., Kyle, R. A., Rajkumar, S. V., Kumar, S. K. & Leung, N., Jan 1 2019, In : British journal of haematology.

Research output: Contribution to journalArticle

3 Scopus citations

Clonotypic light chain peptides identified for monitoring minimal residual disease in multiple myeloma without bone marrow aspiration

Bergen, H. R. B. III., Dasari, S., Dispenzieri, A., Mills, J. R., Ramirez-Alvarado, M., Tschumper, R. C., Jelinek, D. F., Barnidge, D. R. & Murray, D. L., Jan 1 2016, In : Clinical Chemistry. 62, 1, p. 243-251 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Comparison of amyloid fibril formation by two closely related immunoglobulin light chain variable domains

Martin, D. J. & Ramirez-Alvarado, M., Sep 1 2010, In : Amyloid. 17, 3-4, p. 129-136 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Computer-aided design of β-sheet peptides

López, M., Lacroix, E., Ramírez-Alvarado, M. & Serrano, L., Sep 7 2001, In : Journal of Molecular Biology. 312, 1, p. 229-246 18 p.

Research output: Contribution to journalArticle

78 Scopus citations
42 Scopus citations

Conformational exchange on the microsecond time scale in α-helix and β-hairpin peptides measured by 13C NMR transverse relaxation

Nesmelova, I., Krushelnitsky, A., Idiyatullin, D., Blanco, F., Ramirez-Alvarado, M., Daragan, V. A., Serrano, L. & Mayo, K. H., Mar 6 2001, In : Biochemistry. 40, 9, p. 2844-2853 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Cytotoxicity of amyloidogenic immunoglobulin light chains in cell culture

Sikkink, L. A. & Ramirez-Alvarado, M., Nov 1 2010, In : Cell Death and Disease. 1, 11, e98.

Research output: Contribution to journalArticle

34 Scopus citations

De novo design and structural analysis of a model β-hairpin peptide system

Ramírez-Alvarado, M., Blanco, F. J. & Serrano, L., Jul 1 1996, In : Nature Structural Biology. 3, 7, p. 604-612 9 p.

Research output: Contribution to journalArticle

271 Scopus citations

Design of a 20-amino acid, three-stranded β-sheet protein

Kortemme, T., Ramírez-Alvarado, M. & Serrano, L., Jul 10 1998, In : Science. 281, 5374, p. 253-256 4 p.

Research output: Contribution to journalArticle

299 Scopus citations

Differences in immunoglobulin light chain species found in urinary exosomes in light chain amyloidosis (AL)

Ramirez-Alvarado, M., Ward, C. J., Huang, B. Q., Gong, X., Hogan, M. C., Madden, B. J., Charlesworth, M. C. & Leung, N., Jun 18 2012, In : PloS one. 7, 6, e38061.

Research output: Contribution to journalArticle

26 Scopus citations

Differences in Protein Concentration Dependence for Nucleation and Elongation in Light Chain Amyloid Formation

Blancas-Mejía, L. M., Misra, P. & Ramirez-Alvarado, M., Feb 7 2017, In : Biochemistry. 56, 5, p. 757-766 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Differential effects on light chain amyloid formation depend on mutations and type of glycosaminoglycans

Blancas-Mejía, L. M., Hammernik, J., Marin-Argany, M. & Ramirez-Alvarado, M., Feb 20 2015, In : Journal of Biological Chemistry. 290, 8, p. 4953-4965 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Differential recruitment efficacy of patientderived amyloidogenic and myeloma light chain proteins by synthetic fibrilsA metric for predicting amyloid propensity

Martin, E. B., Williams, A., Wooliver, C., Heidel, R. E., Adams, S., Dunlap, J., Ramirez-Alvarado, M., Blancas-Mejia, L. M., Lands, R. H., Kennel, S. J. & Wall, J. S., Mar 1 2017, In : PLoS One. 12, 3, e0174152.

Research output: Contribution to journalArticle

3 Scopus citations

Does the location of a mutation determine the ability to form amyloid fibrils?

Ramírez-Alvarado, M. & Regan, L., Jan 1 2002, In : Journal of Molecular Biology. 323, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Domain:domain interactions within Hop, the Hsp70/Hsp90 organizing protein, are required for protein stability and structure

Carrigan, P. E., Sikkink, L. A., Smith, D. F. & Ramirez-Alvarado, M., Mar 1 2006, In : Protein Science. 15, 3, p. 522-532 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Elongation of the BH8 β-hairpin peptide: Electrostatic interactions in β-hairpin formation and stability

Ramírez-Alvarado, M., Blanco, F. J. & Serrano, L., Jul 4 2001, In : Protein Science. 10, 7, p. 1381-1392 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

Evaluation of the BH3-only protein Puma as a direct Bak activator

Dai, H., Pang, Y. P., Ramirez-Alvarado, M. & Kaufmann, S. H., Jan 3 2014, In : Journal of Biological Chemistry. 289, 1, p. 89-99 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Formation and stability of β-hairpin structures in polypeptides

Blanco, F., Ramírez-Alvarado, M. & Serrano, L., Feb 1998, In : Current Opinion in Structural Biology. 8, 1, p. 107-111 5 p.

Research output: Contribution to journalArticle

134 Scopus citations
26 Scopus citations

Glycosaminoglycans promote fibril formation by amyloidogenic immunoglobulin light chains through a transient interaction

Martin, D. J. & Ramirez-Alvarado, M., Sep 1 2011, In : Biophysical Chemistry. 158, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
78 Scopus citations

Immunoglobulin light chain amyloid aggregation

Blancas-Mejia, L. M., Misra, P., Dick, C. J., Cooper, S. A., Redhage, K. R., Bergman, M. R., Jordan, T. L., Maar, K. & Ramirez-Alvarado, M., Jan 1 2018, In : Chemical Communications. 54, 76, p. 10664-10674 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini

Piehl, D. W., Blancas-Mejía, L. M., Wall, J. S., Kennel, S. J., Ramirez-Alvarado, M. & Rienstra, C. M., Feb 28 2017, In : ACS Omega. 2, 2, p. 712-720 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques

Poduslo, J. F., Ramakrishnan, M., Holasek, S. S., Ramirez-Alvarado, M., Kandimalla, K. K., Gilles, E. J., Curran, G. L. & Wengenack, T. M., Jul 1 2007, In : Journal of neurochemistry. 102, 2, p. 420-433 14 p.

Research output: Contribution to journalArticle

65 Scopus citations
20 Scopus citations

Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations

Blancas-Mejía, L. M., Tischer, A., Thompson, J. R., Tai, J., Wang, L., Auton, M. & Ramirez-Alvarado, M., Jan 23 2014, In : Journal of Molecular Biology. 426, 2, p. 347-361 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

Kinetic stability and sequence/structure studies of urine-derived Bence-Jones proteins from multiple myeloma and light chain amyloidosis patients

Blancas-Mejía, L. M., Martin, E. B., Williams, A., Wall, J. S. & Ramirez-Alvarado, M., 2017, (Accepted/In press) In : Biophysical Chemistry.

Research output: Contribution to journalArticle

2 Scopus citations

Light chain amyloid fibrils cause metabolic dysfunction in human cardiomyocytes

McWilliams-Koeppen, H. P., Foster, J. S., Hackenbrack, N., Ramirez-Alvarado, M., Donohoe, D., Williams, A., Macy, S., Wooliver, C., Wortham, D., Morrell-Falvey, J., Foster, C. M., Kennel, S. J. & Wall, J. S., Sep 22 2015, In : PLoS One. 10, 9, e0137716.

Research output: Contribution to journalArticle

34 Scopus citations

MASS-FIX may allow identification of patients at risk for light chain amyloidosis before the onset of symptoms

Kourelis, T., Murray, D. L., Dasari, S., Kumar, S., Barnidge, D., Madden, B., Arendt, B., Milani, P., Merlini, G., Ramirez-Alvarado, M., Kyle, R. A. & Dispenzieri, A., Jan 1 2018, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

5 Scopus citations

Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains

Misra, P., Blancas-Mejia, L. M. & Ramirez-Alvarado, M., Jun 25 2019, In : Biochemistry. 58, 29, p. 3155-3168 14 p.

Research output: Contribution to journalArticle

Mesenchymal stromal cells protect human cardiomyocytes from amyloid fibril damage

Lin, Y., Marin-Argany, M., Dick, C. J., Redhage, K. R., Blancas-Mejia, L. M., Bulur, P., Butler, G. W., Deeds, M. C., Madden, B. J., Williams, A., Wall, J. S., Dietz, A. B. & Ramirez-Alvarado, M., 2017, (Accepted/In press) In : Cytotherapy.

Research output: Contribution to journalArticle

5 Scopus citations

Monosialoganglioside-containing nanoliposomes restore endothelial function impaired by AL amyloidosis light chain proteins

Franco, D. A., Truran, S., Weissig, V., Guzman-Villanueva, D., Karamanova, N., Senapati, S., Burciu, C., Ramirez-Alvarado, M., Blancas-Mejia, L. M., Lindsay, S., Hari, P. & Migrino, R. Q., Jun 1 2016, In : Journal of the American Heart Association. 5, 6, e003318.

Research output: Contribution to journalArticle

3 Scopus citations