• 3268 Citations
  • 30 Scopus h-Index
19962019
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Research Output 1996 2019

2019

Assays for light chain amyloidosis formation and cytotoxicity

Blancas-Mejia, L. M., Misra, P., Dick, C. J., Marin-Argany, M., Redhage, K. R., Cooper, S. A. & Ramirez-Alvarado, M., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 123-153 31 p. (Methods in Molecular Biology; vol. 1873).

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyloidosis
Immunoglobulin Light Chains
Light
Fluorescence Spectrometry
Fluorescence Microscopy
1 Citation (Scopus)

Clinical features, laboratory characteristics and outcomes of patients with renal versus cardiac light chain amyloidosis

Sidana, S., Tandon, N., Gertz, M., Dispenzieri, A., Ramirez-Alvarado, M., Murray, D. L., Kourelis, T., Buadi, F. K., Kapoor, P., Gonsalves, W., Warsame, R., Lacy, M., Kyle, R. A., Rajkumar, S. V., Kumar, S. K. & Leung, N., Jan 1 2019, In : British journal of haematology.

Research output: Contribution to journalArticle

Amyloidosis
Kidney
Light
Plasma Cells
Bone Marrow Cells
Open Access
Immunoglobulin Light Chains
Glycosylation
Publications
Early Diagnosis
Leukemia

Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains

Misra, P., Blancas-Mejia, L. M. & Ramirez-Alvarado, M., Jun 25 2019, In : Biochemistry. 58, 29, p. 3155-3168 14 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloid
Amyloidosis
Agglomeration
Dimers
2018
4 Citations (Scopus)

Assay to rapidly screen for immunoglobulin light chain glycosylation: a potential path to earlier AL diagnosis for a subset of patients

Kumar, S., Murray, D., Dasari, S., Milani, P., Barnidge, D., Madden, B., Kourelis, T., Arendt, B., Merlini, G., Ramirez-Alvarado, M. & Dispenzieri, A., Jul 6 2018, (Accepted/In press) In : Leukemia. p. 1-4 4 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Glycosylation
Early Diagnosis
3 Citations (Scopus)

Immunoglobulin light chain amyloid aggregation

Blancas-Mejia, L. M., Misra, P., Dick, C. J., Cooper, S. A., Redhage, K. R., Bergman, M. R., Jordan, T. L., Maar, K. & Ramirez-Alvarado, M., Jan 1 2018, In : Chemical Communications. 54, 76, p. 10664-10674 11 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloid
Agglomeration
Proteins
Cells
1 Citation (Scopus)

MASS-FIX may allow identification of patients at risk for light chain amyloidosis before the onset of symptoms

Kourelis, T., Murray, D. L., Dasari, S., Kumar, S., Barnidge, D., Madden, B., Arendt, B., Milani, P., Merlini, G., Ramirez-Alvarado, M., Kyle, R. A. & Dispenzieri, A., Jan 1 2018, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

Amyloidosis
Light
2017
5 Citations (Scopus)

Assessment of renal response with urinary exosomes in patients with AL amyloidosis: A proof of concept

Ramirez-Alvarado, M., Barnidge, D. R., Murray, D. L., Dispenzieri, A., Marin-Argany, M., Dick, C. J., Cooper, S. A., Nasr, S. H., Ward, C. J., Dasari, S., Jiménez-Zepeda, V. H. & Leung, N., Jun 1 2017, In : American Journal of Hematology. 92, 6, p. 536-541 6 p.

Research output: Contribution to journalArticle

Exosomes
Amyloidosis
Kidney
Amyloid
Immunoglobulin Light Chains
26 Citations (Scopus)

Clarifying immunoglobulin gene usage in systemic and localized immunoglobulin light-chain amyloidosis by mass spectrometry

Kourelis, T., Dasari, S., Theis, J. D., Ramirez-Alvarado, M., Kurtin, P. J., Gertz, M., Zeldenrust, S. R., Zenka, R. M., Dogan, A. & Dispenzieri, A., Jan 19 2017, In : Blood. 129, 3, p. 299-306 8 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Immunoglobulin Genes
Amyloidosis
Mass spectrometry
Immunoglobulins
2 Citations (Scopus)

Detection of ALECT2 amyloidosis by positron emission tomography–computed tomography imaging with florbetapir

Leung, N., Ramirez-Alvarado, M., Nasr, S. H., Kemp, B. J. & Johnson, G. B., Apr 1 2017, In : British Journal of Haematology. 177, 1, p. 12 1 p.

Research output: Contribution to journalComment/debate

Amyloidosis
Positron Emission Tomography Computed Tomography
florbetapir
11 Citations (Scopus)

Differences in Protein Concentration Dependence for Nucleation and Elongation in Light Chain Amyloid Formation

Blancas-Mejía, L. M., Misra, P. & Ramirez-Alvarado, M., Feb 7 2017, In : Biochemistry. 56, 5, p. 757-766 10 p.

Research output: Contribution to journalArticle

Amyloid
Elongation
Nucleation
Light
Proteins
3 Citations (Scopus)

Differential recruitment efficacy of patientderived amyloidogenic and myeloma light chain proteins by synthetic fibrilsA metric for predicting amyloid propensity

Martin, E. B., Williams, A., Wooliver, C., Heidel, R. E., Adams, S., Dunlap, J., Ramirez-Alvarado, M., Blancas-Mejia, L. M., Lands, R. H., Kennel, S. J. & Wall, J. S., Mar 1 2017, In : PLoS One. 12, 3, e0174152.

Research output: Contribution to journalArticle

myeloma
amyloid
Amyloid
Light
amyloidosis
10 Citations (Scopus)

Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini

Piehl, D. W., Blancas-Mejía, L. M., Wall, J. S., Kennel, S. J., Ramirez-Alvarado, M. & Rienstra, C. M., Feb 28 2017, In : ACS Omega. 2, 2, p. 712-720 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Proteins
Rigidity
Nuclear magnetic resonance spectroscopy
Conformations
2 Citations (Scopus)

Kinetic stability and sequence/structure studies of urine-derived Bence-Jones proteins from multiple myeloma and light chain amyloidosis patients

Blancas-Mejía, L. M., Martin, E. B., Williams, A., Wall, J. S. & Ramirez-Alvarado, M., 2017, (Accepted/In press) In : Biophysical Chemistry.

Research output: Contribution to journalArticle

Bence Jones Protein
Amyloidosis
Multiple Myeloma
Urine
Light
4 Citations (Scopus)

Mesenchymal stromal cells protect human cardiomyocytes from amyloid fibril damage

Lin, Y., Marin-Argany, M., Dick, C. J., Redhage, K. R., Blancas-Mejia, L. M., Bulur, P., Butler, G. W., Deeds, M. C., Madden, B. J., Williams, A., Wall, J. S., Dietz, A. B. & Ramirez-Alvarado, M., 2017, (Accepted/In press) In : Cytotherapy.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Amyloid
Cardiac Myocytes
Light
Growth

Recruitment of human light chain proteins by synthetic fibrils is dependent on disease state and may be used to predict amyloidogenic propensity

Martin, E. B., Williams, A., Wooliver, C., Heidel, R. E., Adams, S., Dunlap, J., Ramirez-Alvarado, M., Blancas-Mejia, L., Kennel, S. J. & Wall, J. S., Mar 16 2017, In : Amyloid. 24, p. 24-25 2 p.

Research output: Contribution to journalLetter

Light
Proteins
28 Citations (Scopus)

ThT 101: a primer on the use of thioflavin T to investigate amyloid formation

Gade Malmos, K., Blancas-Mejia, L. M., Weber, B., Buchner, J., Ramirez-Alvarado, M., Naiki, H. & Otzen, D., Mar 27 2017, (Accepted/In press) In : Amyloid. p. 1-16 16 p.

Research output: Contribution to journalArticle

Amyloid
Artifacts
thioflavin T
Proteins
2016
1 Citation (Scopus)

B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease

Holditch, S. J., Schreiber, C. A., Harris, P. C., La Russo, N. F., Ramirez-Alvarado, M., Cataliotti, A., Torres, V. & Ikeda, Y. H., Jul 22 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Brain Natriuretic Peptide
Vasopressins
Disease Progression
Kidney
18 Citations (Scopus)

Cell damage in light chain amyloidosis fibril internalization, toxicity and cell-mediated seeding

Marin-Argany, M., Lin, Y., Misra, P., Williams, A., Wall, J. S., Howell, K. G., Elsbernd, L. R., McClure, M. & Ramirez-Alvarado, M., Sep 16 2016, In : Journal of Biological Chemistry. 291, 38, p. 19813-19825 13 p.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Toxicity
Cells
Immunoglobulin Light Chains
20 Citations (Scopus)

Clonotypic light chain peptides identified for monitoring minimal residual disease in multiple myeloma without bone marrow aspiration

Bergen, H. R. B. III., Dasari, S., Dispenzieri, A., Mills, J. R., Ramirez-Alvarado, M., Tschumper, R. C., Jelinek, D. F., Barnidge, D. R. & Murray, D. L., Jan 1 2016, In : Clinical Chemistry. 62, 1, p. 243-251 9 p.

Research output: Contribution to journalArticle

Residual Neoplasm
Multiple Myeloma
Bone
Bone Marrow
Light
2 Citations (Scopus)

Monosialoganglioside-containing nanoliposomes restore endothelial function impaired by AL amyloidosis light chain proteins

Franco, D. A., Truran, S., Weissig, V., Guzman-Villanueva, D., Karamanova, N., Senapati, S., Burciu, C., Ramirez-Alvarado, M., Blancas-Mejia, L. M., Lindsay, S., Hari, P. & Migrino, R. Q., Jun 1 2016, In : Journal of the American Heart Association. 5, 6, e003318.

Research output: Contribution to journalArticle

Amyloidosis
Light
Proteins
Antioxidants
Arterioles
11 Citations (Scopus)

Recruitment of Light Chains by Homologous and Heterologous Fibrils Shows Distinctive Kinetic and Conformational Specificity

Blancas-Mejía, L. M. & Ramirez-Alvarado, M., May 31 2016, In : Biochemistry. 55, 21, p. 2967-2978 12 p.

Research output: Contribution to journalArticle

Seed
Seeds
Light
Kinetics
Amyloidogenic Proteins
7 Citations (Scopus)

Solid-state NMR chemical shift assignments for AL-09 VL immunoglobulin light chain fibrils

Piehl, D. W., Blancas-Mejía, L. M., Ramirez-Alvarado, M. & Rienstra, C. M., Oct 22 2016, (Accepted/In press) In : Biomolecular NMR Assignments. p. 1-6 6 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Chemical shift
Amyloidosis
Nuclear magnetic resonance
Light
2015
21 Citations (Scopus)

Differential effects on light chain amyloid formation depend on mutations and type of glycosaminoglycans

Blancas-Mejía, L. M., Hammernik, J., Marin-Argany, M. & Ramirez-Alvarado, M., Feb 20 2015, In : Journal of Biological Chemistry. 290, 8, p. 4953-4965 13 p.

Research output: Contribution to journalArticle

Glycosaminoglycans
Amyloid
Light
Mutation
Proteins
30 Citations (Scopus)

Light chain amyloid fibrils cause metabolic dysfunction in human cardiomyocytes

McWilliams-Koeppen, H. P., Foster, J. S., Hackenbrack, N., Ramirez-Alvarado, M., Donohoe, D., Williams, A., Macy, S., Wooliver, C., Wortham, D., Morrell-Falvey, J., Foster, C. M., Kennel, S. J. & Wall, J. S., Sep 22 2015, In : PLoS One. 10, 9, e0137716.

Research output: Contribution to journalArticle

amyloid
Amyloid
Cardiac Myocytes
Light
amyloidosis
12 Citations (Scopus)

Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils

Marin-Argany, M., Güell-Bosch, J., Blancas-Mejía, L. M., Villegas, S. & Ramirez-Alvarado, M., 2015, In : Protein Science. p. 1829-1840 12 p.

Research output: Contribution to journalArticle

Amyloid
Light
Mutation
Amyloidosis
Proteins
19 Citations (Scopus)

Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding

Blancas-Mejía, L. M., Horn, T. J., Marin-Argany, M., Auton, M. T., Tischer, A. & Ramirez-Alvarado, M., Aug 12 2015, In : Biophysical Chemistry. 207, p. 13-20 8 p., 5846.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Thermodynamics
Amyloid
Hot Temperature
Light
2014
16 Citations (Scopus)

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., Cummins, N. W., Correia, C., Meng, X. W., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., 2014, In : Journal of Cell Biology. 206, 7, p. 867-876 10 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
HIV
T-Lymphocytes
Caspase 8
Cell Death
1 Citation (Scopus)

Correction to Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation [Journal of Cell Biology, 206, 7, (2014), 867-876]

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., Cummins, N. W., Correia, C., Wei Meng, X., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., 2014, In : Journal of Cell Biology. 207, 1, p. 159 1 p.

Research output: Contribution to journalArticle

HIV Protease
Cell Biology
T-Lymphocytes
38 Citations (Scopus)

Evaluation of the BH3-only protein Puma as a direct Bak activator

Dai, H., Pang, Y-P., Ramirez-Alvarado, M. & Kaufmann, S. H., Jan 3 2014, In : Journal of Biological Chemistry. 289, 1, p. 89-99 11 p.

Research output: Contribution to journalArticle

Puma
Oligomerization
Noxae
Proteins
Membranes
27 Citations (Scopus)

Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations

Blancas-Mejía, L. M., Tischer, A., Thompson, J. R., Tai, J., Wang, L., Auton, M. T. & Ramirez-Alvarado, M., Jan 23 2014, In : Journal of Molecular Biology. 426, 2, p. 347-361 15 p.

Research output: Contribution to journalArticle

Protein Folding
Amyloidosis
Light
Mutation
Thermodynamics
9 Citations (Scopus)

Nanoliposomes protect against AL amyloid light chain protein-induced endothelial injury

Truran, S., Weissig, V., Ramirez-Alvarado, M., Franco, D. A., Burciu, C., Georges, J., Murarka, S., Okoth, W. A., Schwab, S., Hari, P. & Migrino, R. Q., Mar 2014, In : Journal of Liposome Research. 24, 1, p. 69-73 5 p.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Light
Wounds and Injuries
Proteins
18 Citations (Scopus)

Phenotyping polyclonal kappa and lambda light chain molecular mass distributions in patient serum using mass spectrometry

Barnidge, D. R., Dasari, S., Ramirez-Alvarado, M., Fontan, A., Willrich, M. A. V., Tschumper, R. C., Jelinek, D. F., Snyder, M. R., Dispenzieri, A., Katzmann, J. A. & Murray, D. L., Nov 7 2014, In : Journal of Proteome Research. 13, 11, p. 5198-5205 8 p.

Research output: Contribution to journalArticle

Molecular mass
Mass spectrometry
Mass Spectrometry
Hypergammaglobulinemia
Immunoglobulin Light Chains
2013
1 Citation (Scopus)

Erratum: Structural and functional studies of truncated hemolysin A from Proteus mirabilis (Journal of Biological Chemistry)

Weaver, T. M., Smith, J. A., Hocking, J. M., Bailey, L. J., Wawrzyn, G. T., Howard, D. R., Sikkink, L. A., Ramirez-Alvarado, M. & Thompson, J. R., Apr 5 2013, In : Journal of Biological Chemistry. 288, 14, p. 10092 1 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Role of mutations in the cellular internalization of amyloidogenic light chains into cardiomyocytes

Levinson, R. T., Olatoye, O. O., Randles, E. G., Howell, K. G., DiCostanzo, A. C. & Ramirez-Alvarado, M., 2013, In : Scientific Reports. 3, 1278.

Research output: Contribution to journalArticle

Cardiac Myocytes
Light
Mutation
Proteins
Amyloidosis
101 Citations (Scopus)

Systemic amyloidoses

Blancas-Mejía, L. M. & Ramirez-Alvarado, M., Jun 2013, In : Annual Review of Biochemistry. 82, p. 745-774 30 p.

Research output: Contribution to journalArticle

Protein Precursors
Amyloidosis
Amyloid
Tissue
Cell death
19 Citations (Scopus)

Thermal stability threshold for amyloid formation in light chain amyloidosis

Poshusta, T. L., Katoh, N., Gertz, M., Dispenzieri, A. & Ramirez-Alvarado, M., Nov 15 2013, In : International Journal of Molecular Sciences. 14, 11, p. 22604-22617 14 p.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Thermodynamic stability
thermal stability
Hot Temperature
2012
16 Citations (Scopus)

Alzheimer's disease amyloid β-protein mutations and deletions that define neuronal binding/internalization as early stage nonfibrillar/fibrillar aggregates and late stage fibrils

Poduslo, J. F., Howell, K. G., Olson, N. C., Ramirez-Alvarado, M. & Kandimalla, K. K., May 15 2012, In : Biochemistry. 51, 19, p. 3993-4003 11 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Sequence Deletion
Alzheimer Disease
Rigidity
Neurons
31 Citations (Scopus)

Amyloid formation in light chain amyloidosis

Ramirez-Alvarado, M., 2012, In : Current Topics in Medicinal Chemistry. 12, 22, p. 2523-2533 11 p.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Light
Thermodynamics
Immunoglobulin Light Chains
26 Citations (Scopus)

Differences in immunoglobulin light chain species found in urinary exosomes in light chain amyloidosis (AL)

Ramirez-Alvarado, M., Ward, C. J., Huang, B. Q., Gong, X., Hogan, M. C., Madden, B. J., Charlesworth, M. C. & Leung, N., Jun 18 2012, In : PLoS One. 7, 6, e38061.

Research output: Contribution to journalArticle

immunoglobulin light chains
exosomes
Exosomes
Immunoglobulin Light Chains
amyloidosis
15 Citations (Scopus)

Tyrosine residues mediate fibril formation in a dynamic light chain dimer interface

DiCostanzo, A. C., Thompson, J. R., Peterson, F. C., Volkman, B. F. & Ramirez-Alvarado, M., Aug 10 2012, In : Journal of Biological Chemistry. 287, 33, p. 27997-28006 10 p.

Research output: Contribution to journalArticle

Dimers
Tyrosine
Light
Amyloid
Conformations

Tyrosine residues mediate fibril formation in a dynamic light chain dimer interface (The Journal of Biological Chemistry (2012) 287 (27997-28006))

DiCostanzo, A. C., Thompson, J. R., Peterson, F. C., Volkman, B. F. & Ramirez-Alvarado, M., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35541 1 p.

Research output: Contribution to journalArticle

Tyrosine
Light
40 Citations (Scopus)
Paraproteinemias
Kidney Diseases
Albumins
Light
Amyloidosis
2011
2 Citations (Scopus)

A reappraisal of immunoglobulin variable gene primers and its impact on assessing clonal relationships between PB B cells and BM plasma cells in AL amyloidosis

Katoh, N., Poshusta, T. L., Manske, M. K., Dispenzieri, A., Gertz, M., Abraham, R. S. & Ramirez-Alvarado, M., Dec 2011, In : Journal of Clinical Immunology. 31, 6, p. 1029-1037 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Genes
Amyloidosis
Plasma Cells
Bone Marrow Cells
Blood Cells
16 Citations (Scopus)
Immunoglobulin Light Chains
Glycosaminoglycans
Amyloidogenic Proteins
Amyloid
Protein Precursors
2010
29 Citations (Scopus)

A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface

Peterson, F. C., Baden, E. M., Owen, B. A. L., Volkman, B. F. & Ramirez-Alvarado, M., May 2010, In : Structure. 18, 5, p. 563-570 8 p.

Research output: Contribution to journalArticle

Light
Mutation
Amyloid
Proteostasis Deficiencies
Proteins
54 Citations (Scopus)

Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the co-chaperone p23

Chadli, A., Felts, S. J., Wang, Q., Sullivan, W. P., Botuyan, M. V., Fauq, A., Ramirez-Alvarado, M. & Mer, G., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 4224-4231 8 p.

Research output: Contribution to journalArticle

Steroid Receptors
Adenosine Triphosphate
Dissection
Molecules
Molecular Chaperones
20 Citations (Scopus)

Comparison of amyloid fibril formation by two closely related immunoglobulin light chain variable domains

Martin, D. J. & Ramirez-Alvarado, M., Sep 2010, In : Amyloid. 17, 3-4, p. 129-136 8 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloid
Amyloidosis
Phenotype
Light
30 Citations (Scopus)

Cytotoxicity of amyloidogenic immunoglobulin light chains in cell culture

Sikkink, L. A. & Ramirez-Alvarado, M., Nov 2010, In : Cell Death and Disease. 1, 11, e98.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloidosis
Poisons
Proteostasis Deficiencies
Cell Culture Techniques
1 Citation (Scopus)

Preface

Ramirez-Alvarado, M., Kelly, J. W. & Dobson, C. M., Jul 2 2010, In : Unknown Journal.

Research output: Contribution to journalArticle