Lewis Rowland Roberts, MB, ChB, PhD

  • 18238 Citations
  • 73 Scopus h-Index
1991 …2020

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Article
2020

Diabetes Is Associated With Increased Risk of Hepatocellular Carcinoma in Patients With Cirrhosis From Nonalcoholic Fatty Liver Disease

Yang, J. D., Ahmed, F., Mara, K. C., Addissie, B. D., Allen, A. M., Gores, G. J. & Roberts, L. R., Mar 1 2020, In : Hepatology. 71, 3, p. 907-916 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Epidemiology of Liver Cancer in Africa: Current and Future Trends

Okeke, E., Davwar, P. M., Roberts, L., Sartorius, K., Spearman, W., Malu, A. & Duguru, M., May 1 2020, In : Seminars in liver disease. 40, 2, p. 111-123 13 p.

Research output: Contribution to journalArticle

Knowledge, Attitudes, and Behaviors of Viral Hepatitis Among Recent African Immigrants in the United States: A Community Based Participatory Research Qualitative Study

Mohamed, E. A., Giama, N. H., Shaleh, H. M., Kerandi, L., Oseini, A. M., Ahmed Mohammed, H., Kerandi, H., Allotey, L. K., Waaeys, I. A., Ali, H. A., Ali, H. M., Mohamed, S. A., Yang, J. D., Gaga, W. O., Tamire, L. L., Windissa, A., Patten, C. A., Balls-Berry, J. E. & Roberts, L. R., Mar 6 2020, In : Frontiers in Public Health. 8, 25.

Research output: Contribution to journalArticle

Open Access

Neutrophil to lymphocyte ratio as a prognostic marker in metastatic gallbladder cancer

Mady, M., Prasai, K., Tella, S. H., Yadav, S., Hallemeier, C. L., Rakshit, S., Roberts, L., Borad, M. & Mahipal, A., Jan 1 2020, (Accepted/In press) In : HPB.

Research output: Contribution to journalArticle

The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoterlooping GLI1-STAT3 transcriptional complex

Carr, R. M., Duran, P. A. R., Tolosa, E. J., Ma, C., Oseini, A. M., Moser, C. D., Banini, B. A., Huang, J., Asumda, F., Dhanasekaran, R., Graham, R. P., Toruner, M. D., Safgren, S. L., Almada, L. L., Wang, S., Patnaik, M. M., Roberts, L. R. & Fernandez-Zapico, M. E., Feb 28 2020, In : Journal of Biological Chemistry. 295, 9, p. 2698-2712 15 p.

Research output: Contribution to journalArticle

Type 3 Inositol 1,4,5-Trisphosphate Receptor Is Increased and Enhances Malignant Properties in Cholangiocarcinoma

Ueasilamongkol, P., Khamphaya, T., Guerra, M. T., Rodrigues, M. A., Gomes, D. A., Kong, Y., Wei, W., Jain, D., Trampert, D. C., Ananthanarayanan, M., Banales, J. M., Roberts, L. R., Farshidfar, F., Nathanson, M. H. & Weerachayaphorn, J., Feb 1 2020, In : Hepatology. 71, 2, p. 583-599 17 p.

Research output: Contribution to journalArticle

5 Scopus citations
2019

Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B

the Hepatitis B Research Network (HBRN), Jul 2019, In : Journal of viral hepatitis. 26, 7, p. 856-865 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., Nelson, G., Bronk, S., Fierro Velasco, R. O., van Deursen, E. J., O'Brien, D. R., Kocher, J-P., Youssef, S. A., van Ree, J. H., de Bruin, A., van den Bos, H., Spierings, D. C. J., Foijer, F., van de Sluis, B., Roberts, L. R. & 3 others, Gores, G. J., Li, H. & Van Deursen, J., Jul 1 2019, In : Gastroenterology. 157, 1, p. 210-226.e12

Research output: Contribution to journalArticle

6 Scopus citations

Distinct phenotype and function of circulating Vδ1+ and Vδ2+ γδT-cells in acute and chronic hepatitis B

Chang, K. M., Traum, D., Park, J. J., Ho, S., Ojiro, K., Wong, D. K., Wahed, A. S., Terrault, N. A., Khalili, M., Sterling, R. K., Janssen, H. L. A., Shuhart, M. C., Lau, D. T., Roberts, L. R., Johnson, G. S., Kaplan, D. E., Betts, M. R., Lee, W. M. & Lok, A. S. F., Jan 1 2019, In : PLoS pathogens. 15, 4, e1007715.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma

Zheng, Y., Hlady, R. A., Joyce, B. T., Robertson, K. D., He, C., Nannini, D. R., Kibbe, W. A., Achenbach, C. J., Murphy, R. L., Roberts, L. R. & Hou, L., Oct 21 2019, In : Clinical Epigenetics. 11, 1, 145.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

GALAD score for hepatocellular carcinoma detection in comparison with liver ultrasound and proposal of Galadus score

Yang, J. D., Addissie, B. D., Mara, K. C., Harmsen, W. S., Dai, J., Zhang, N., Wongjarupong, N., Ali, H. M., Ali, H. A., Hassan, F. A., Lavu, S., Cvinar, J. L., Giama, N. H., Moser, C. D., Miyabe, K., Allotey, L. K., Algeciras-Schimnich, A., Theobald, J. P., Ward, M. M., Nguyen, M. H. & 11 others, Befeler, A. S., Reddy, K. R., Schwartz, M., Harnois, D. M., Yamada, H., Srivastava, S., Rinaudo, J. A., Gores, G. J., Feng, Z., Marrero, J. A. & Roberts, L. R., Mar 2019, In : Cancer Epidemiology Biomarkers and Prevention. 28, 3, p. 531-538 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Gallbladder cancer: Epidemiology and genetic risk associations

Schmidt, M. A., Marcano-Bonilla, L. & Roberts, L. R., Aug 1 2019, In : Chinese Clinical Oncology. 8, 4, 31.

Research output: Contribution to journalArticle

1 Scopus citations

Genetic features associated with 18 F-FDG uptake in intrahepatic cholangiocarcinoma

Ahn, K. S., Kang, K. J., Kim, Y. H., Kim, T. S., Song, B. I., Kim, H. W., O’Brien, D., Roberts, L. R., Lee, J. W. & Won, K. S., Apr 1 2019, In : Annals of Surgical Treatment and Research. 96, 4, p. 153-161 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Genome-wide discovery and validation of diagnostic DNA methylation-based biomarkers for hepatocellular cancer detection in circulating cell free DNA

Hlady, R. A., Zhao, X., Pan, X., Dong Yang, J., Ahmed, F., Antwi, S. O., Giama, N. H., Patel, T., Roberts, L. R., Liu, C. & Robertson, K. D., Jan 1 2019, In : Theranostics. 9, 24, p. 7239-7250 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Genomic Medicine and Implications for Hepatocellular Carcinoma Prevention and Therapy

Dhanasekaran, R., Nault, J. C., Roberts, L. R. & Zucman-Rossi, J., Jan 1 2019, In : Gastroenterology. 156, 2, p. 492-509 18 p.

Research output: Contribution to journalArticle

26 Scopus citations

Hepatocellular Carcinoma Detection by Plasma Methylated DNA: Discovery, Phase I Pilot, and Phase II Clinical Validation

Kisiel, J. B., Dukek, B. A., V.S.R. Kanipakam, R., Ghoz, H. M., Yab, T. C., Berger, C. K., Taylor, W. R., Foote, P. H., Giama, N. H., Onyirioha, K., Abdallah, M. A., Burger, K. N., Slettedahl, S. W., Mahoney, D. W., Smyrk, T. C., Lewis, J. T., Giakoumopoulos, M., Allawi, H. T., Lidgard, G. P., Roberts, L. R. & 1 others, Ahlquist, D. A., Jan 1 2019, In : Hepatology.

Research output: Contribution to journalArticle

19 Scopus citations

Neoadjuvant vs. adjuvant chemotherapy for cholangiocarcinoma: A propensity score matched analysis

Yadav, S., Xie, H., Bin-Riaz, I., Sharma, P., Durani, U., Goyal, G., Borah, B. J., Borad, M. J., Smoot, R., Roberts, L. R., Go, R. S., Mc Williams, R. R. & Mahipal, A., Jan 1 2019, In : European Journal of Surgical Oncology.

Research output: Contribution to journalArticle

6 Scopus citations

Nutritional management of cirrhosis patients: A qualitative study exploring perceptions of patients and health workers in Ghana

Nartey, Y. A., Asem, M., Agyei-Nkansah, A., Awuku, Y. A., Setorglo, J., Duah, A., Bampoh, S., Ayawin, J., Asibey, S. O., Ye, W., Afihene, M. Y., Roberts, L. & Plymoth, A., Dec 2019, In : Clinical Nutrition ESPEN. 34, p. 18-22 5 p.

Research output: Contribution to journalArticle

Open Access

Preclinical In Vitro and In Vivo Evidence of an Antitumor Effect of CX-4945, a Casein Kinase II Inhibitor, in Cholangiocarcinoma

Zakharia, K., Miyabe, K., Wang, Y., Wu, D., Moser, C. D., Borad, M. J. & Roberts, L. R., Jan 1 2019, In : Translational Oncology. 12, 1, p. 143-153 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Prognostic subclass of intrahepatic cholangiocarcinoma by integrative molecular–clinical analysis and potential targeted approach

Ahn, K. S., O’Brien, D., Kang, Y. N., Mounajjed, T., Kim, Y. H., Kim, T. S., Kocher, J-P., Allotey, L. K., Borad, M. J., Roberts, L. R. & Kang, K. J., Jan 1 2019, In : Hepatology International.

Research output: Contribution to journalArticle

2 Scopus citations

Rationale and design of the Hepatocellular carcinoma Early Detection Strategy study: A multi-center longitudinal initiative of the National Cancer Institute's Early Detection Research Network

Borges, E. A., Dai, J., Parikh, N. D., Schwartz, M., Nguyen, M. H., Roberts, L. R., Befeler, A. S., Srivastava, S., Rinaudo, J. A., Feng, Z., Marrero, J. A. & Reddy, K. R., Jan 2019, In : Contemporary Clinical Trials. 76, p. 49-54 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Recent developments and therapeutic strategies against hepatocellular carcinoma

Yarchoan, M., Agarwal, P., Villanueva, A., Rao, S., Dawson, L. A., Llovet, J. M., Finn, R. S., Groopman, J. D., El-Serag, H. B., Monga, S. P., Wang, X. W., Karin, M., Schwartz, R. E., Tanabe, K. K., Roberts, L. R., Gunaratne, P. H., Tsung, A., Brown, K. A., Lawrence, T. S., Salem, R. & 13 others, Singal, A. G., Kim, A. K., Rabiee, A., Resar, L., Hoshida, Y., He, A. R., Ghoshal, K., Ryan, P. B., Jaffee, E. M., Guha, C., Mishra, L., Norman Coleman, C. & Ahmed, M. M., Sep 1 2019, In : Cancer research. 79, 17, p. 4326-4330 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Role of Killer cell immunoglobulin-like receptors (KIR) genes in stages of HIV-1 infection among patients from Burkina Faso

Sorgho, P. A., Djigma, F. W., Martinson, J. J., Yonli, A. T., Nagalo, B. M., Compaore, T. R., Diarra, B., Sombie, H. K., Simpore, A., Zongo, A. W., Ouattara, A. K., Soubeiga, S. T. R., Traore, L., Yelemkoure, E. T., Kiendrebeogo, I. T., Roberts, L. R. & Simpore, J., Dec 19 2019, In : Biomolecular concepts. 10, 1, p. 226-236 11 p.

Research output: Contribution to journalArticle

Open Access

Single-dose neoadjuvant akt pathway inhibitor reduces growth of hepatocellular carcinoma after laser thermal ablation in small-animal model

Jondal, D. E., Thompson, S. M., Butters, K. A., Knudsen, B. E., Anderson, J. L., Roberts, L. R., Callstrom, M. R. & Woodrum, D. A., Jan 1 2019, In : Radiology. 292, 3, p. 752-759 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
2018

AASLD guidelines for the treatment of hepatocellular carcinoma

Heimbach, J. K., Kulik, L. M., Finn, R. S., Sirlin, C. B., Abecassis, M. M., Roberts, L. R., Zhu, A. X., Murad, M. H. & Marrero, J. A., Jan 2018, In : Hepatology. 67, 1, p. 358-380 23 p.

Research output: Contribution to journalArticle

675 Scopus citations

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 690-705.e9

Research output: Contribution to journalArticle

94 Scopus citations

A model predicting short-term mortality in patients with advanced liver cirrhosis and concomitant infection

Li, Y., Chaiteerakij, R., Kwon, J. H., Jang, J. W., Lee, H. L., Cha, S., Ding, X. W., Thongprayoon, C., Ha, F. S., Nie, C. Y., Zhang, Q., Yang, Z., Giama, N. H., Roberts, L. R. & Han, T., Oct 1 2018, In : Medicine. 97, 41, p. e12758

Research output: Contribution to journalArticle

1 Scopus citations

An Enlarging Metastatic Calcified Liver Lesion of an Occult Melanoma

Mouchli, M. A., Kerr, S. E. & Roberts, L. R., Jun 18 2018, (Accepted/In press) In : Case Reports in Oncology. p. 388-391 4 p.

Research output: Contribution to journalArticle

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 400-416.e11

Research output: Contribution to journalArticle

232 Scopus citations

Anti-viral therapy is associated with improved survival but is underutilised in patients with hepatitis B virus-related hepatocellular carcinoma: real-world east and west experience

Chen, V. L., Yeh, M. L., Le, A. K., Jun, M., Saeed, W. K., Yang, J. D., Huang, C. F., Lee, H. Y., Tsai, P. C., Lee, M. H., Giama, N., Kim, N. G., Nguyen, P. P., Dang, H., Ali, H. A., Zhang, N., Huang, J. F., Dai, C. Y., Chuang, W. L., Roberts, L. R. & 4 others, Jun, D. W., Lim, Y. S., Yu, M. L. & Nguyen, M. H., Jul 1 2018, In : Alimentary Pharmacology and Therapeutics. 48, 1, p. 44-54 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 386-399.e12

Research output: Contribution to journalArticle

45 Scopus citations

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

The Cancer Genome Atlas Research Network, Oct 24 2018, In : Cell Systems. 7, 4, p. 422-437.e7

Research output: Contribution to journalArticle

21 Scopus citations

Association between treatment facility volume, therapy types and overall survival in patients with intrahepatic cholangiocarcinoma

Kommalapati, A., Tella, S. H., Goyal, G., Borad, M. J., Alberts, S. R., Roberts, L. R., Hubbard, J. M., Durgin, L., Cleary, S. & Mahipal, A., Jan 1 2018, (Accepted/In press) In : HPB.

Research output: Contribution to journalArticle

1 Scopus citations

Barriers in Hepatitis C Treatment in Somali Patients in the Direct Acting Antiviral Therapy Era

Elwir, S., Anugwom, C., Connor, E. K., Giama, N. H., Ndzengue, A., Menk, J., Mohamed, E. A., Roberts, L. R. & Hassan, M., Jan 1 2018, (Accepted/In press) In : Journal of the National Medical Association.

Research output: Contribution to journalArticle

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

The Cancer Genome Atlas Network, Apr 5 2018, In : Cell. 173, 2, p. 291-304.e6

Research output: Contribution to journalArticle

247 Scopus citations

Clinical Features Associated with Survival Outcome in African-American Patients with Hepatocellular Carcinoma

Estevez, J., Yang, J. D., Leong, J., Nguyen, P., Giama, N. H., Zhang, N., Ali, H. A., Lee, M. H., Cheung, R., Roberts, L. R., Schwartz, M. & Nguyen, M. H., Jan 1 2018, (Accepted/In press) In : American Journal of Gastroenterology.

Research output: Contribution to journalArticle

4 Scopus citations

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 721-735.e8

Research output: Contribution to journalArticle

68 Scopus citations

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

The Cancer Genome Atlas Research Network, Aug 13 2018, In : Cancer cell. 34, 2, p. 211-224.e6

Research output: Contribution to journalArticle

101 Scopus citations

Comprehensive Characterization of Cancer Driver Genes and Mutations

The MC3 Working Group & The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 371-385.e18

Research output: Contribution to journalArticle

278 Scopus citations

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

The Cancer Genome Atlas Research Network, Oct 30 2018, In : Cell reports. 25, 5, p. 1304-1317.e5

Research output: Contribution to journalArticle

29 Scopus citations

Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases

Marrero, J. A., Kulik, L. M., Sirlin, C. B., Zhu, A. X., Finn, R. S., Abecassis, M. M., Roberts, L. R. & Heimbach, J. K., Aug 1 2018, In : Hepatology. 68, 2, p. 723-750 28 p.

Research output: Contribution to journalArticle

353 Scopus citations

DNA methylation of telomere-related genes and cancer risk

Joyce, B. T., Zheng, Y., Nannini, D., Zhang, Z., Liu, L., Gao, T., Kocherginsky, M., Murphy, R., Yang, H., Achenbach, C. J., Roberts, L. R., Hoxha, M., Shen, J., Vokonas, P., Schwartz, J., Baccarelli, A. & Hou, L., Aug 1 2018, In : Cancer Prevention Research. 11, 8, p. 511-522 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

The Fusion Analysis Working Group & The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 227-238.e3

Research output: Contribution to journalArticle

85 Scopus citations

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 194-212.e6

Research output: Contribution to journalArticle

51 Scopus citations

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 676-689.e3

Research output: Contribution to journalArticle

88 Scopus citations

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 239-254.e6

Research output: Contribution to journalArticle

126 Scopus citations