Lewis Rowland Roberts, MB, ChB, PhD

  • 14877 Citations
  • 66 Scopus h-Index
1991 …2020
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Research Output 1991 2019

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Article
2019

Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B

the Hepatitis B Research Network (HBRN), Jul 1 2019, In : Journal of viral hepatitis. 26, 7, p. 856-865 10 p.

Research output: Contribution to journalArticle

Hepatitis B e Antigens
Chronic Hepatitis B
Genotype
Hepatitis B virus
Virus Diseases
1 Citation (Scopus)

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., Nelson, G., Bronk, S., Fierro Velasco, R. O., van Deursen, E. J., O'Brien, D. R., Kocher, J-P., Youssef, S. A., van Ree, J. H., de Bruin, A., van den Bos, H., Spierings, D. C. J., Foijer, F., van de Sluis, B., Roberts, L. R. & 3 others, Gores, G. J., Li, H. & Van Deursen, J., Jul 1 2019, In : Gastroenterology. 157, 1, p. 210-226.e12

Research output: Contribution to journalArticle

Chromosomal Instability
Cyclins
Liver
Neoplasms
Chromosomes
1 Citation (Scopus)

Distinct phenotype and function of circulating Vδ1+ and Vδ2+ γδT-cells in acute and chronic hepatitis B

Hepatitis B Research Network (HBRN), Apr 1 2019, In : PLoS pathogens. 15, 4, p. e1007715

Research output: Contribution to journalArticle

Open Access
Chronic Hepatitis B
T-Lymphocytes
Phenotype
Hepatitis B
Hepatitis B virus
2 Citations (Scopus)

GALAD score for hepatocellular carcinoma detection in comparison with liver ultrasound and proposal of Galadus score

Yang, J. D., Addissie, B. D., Mara, K. C., Harmsen, W. S., Dai, J., Zhang, N., Wongjarupong, N., Ali, H. M., Ali, H. A., Hassan, F. A., Lavu, S., Cvinar, J. L., Giama, N. H., Moser, C. D., Miyabe, K., Allotey, L. K., Algeciras-Schimnich, A., Theobald, J. P., Ward, M. M., Nguyen, M. H. & 11 others, Befeler, A. S., Reddy, K. R., Schwartz, M., Harnois, D., Yamada, H., Srivastava, S., Rinaudo, J. A., Gores, G. J., Feng, Z., Marrero, J. A. & Roberts, L. R., Mar 1 2019, In : Cancer Epidemiology Biomarkers and Prevention. 28, 3, p. 531-538 8 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Liver
ROC Curve
Area Under Curve
Fibrosis

Gallbladder cancer: Epidemiology and genetic risk associations

Schmidt, M. A., Marcano-Bonilla, L. & Roberts, L. R., Aug 1 2019, In : Chinese Clinical Oncology. 8, 4, 31.

Research output: Contribution to journalArticle

Gallbladder Neoplasms
Molecular Epidemiology
North American Indians
South America
Genome-Wide Association Study
1 Citation (Scopus)

Genetic features associated with 18 F-FDG uptake in intrahepatic cholangiocarcinoma

Ahn, K. S., Kang, K. J., Kim, Y. H., Kim, T. S., Song, B. I., Kim, H. W., O’Brien, D., Roberts, L. R., Lee, J. W. & Won, K. S., Apr 1 2019, In : Annals of Surgical Treatment and Research. 96, 4, p. 153-161 9 p.

Research output: Contribution to journalArticle

Open Access
Cholangiocarcinoma
RNA Sequence Analysis
Cell Cycle
Fluorodeoxyglucose F18
gemcitabine
5 Citations (Scopus)

Genomic Medicine and Implications for Hepatocellular Carcinoma Prevention and Therapy

Dhanasekaran, R., Nault, J. C., Roberts, L. R. & Zucman-Rossi, J., Jan 1 2019, In : Gastroenterology. 156, 2, p. 492-509 18 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Medicine
Liver Neoplasms
Aflatoxins
Fatty Liver
5 Citations (Scopus)

Hepatocellular Carcinoma Detection by Plasma Methylated DNA: Discovery, Phase I Pilot, and Phase II Clinical Validation

Kisiel, J. B., Dukek, B. A., V.S.R. Kanipakam, R., Ghoz, H. M., Yab, T. C., Berger, C. K., Taylor, W. R., Foote, P. H., Giama, N. H., Onyirioha, K., Abdallah, M. A., Burger, K. N., Slettedahl, S. W., Mahoney, D. W., Smyrk, T. C., Lewis, J. T., Giakoumopoulos, M., Allawi, H. T., Lidgard, G. P., Roberts, L. R. & 1 others, Ahlquist, D. A., Jan 1 2019, In : Hepatology.

Research output: Contribution to journalArticle

Genetic Markers
Hepatocellular Carcinoma
DNA
Area Under Curve
Homeobox Genes
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Metformin
Hepatocellular Carcinoma
Joints
Survival

Neoadjuvant vs. adjuvant chemotherapy for cholangiocarcinoma: A propensity score matched analysis

Yadav, S., Xie, H., Bin-Riaz, I., Sharma, P., Durani, U., Goyal, G., Borah, B. J., Borad, M. J., Smoot, R., Roberts, L. R., Go, R. S., Mc Williams, R. R. & Mahipal, A., Jan 1 2019, In : European Journal of Surgical Oncology.

Research output: Contribution to journalArticle

Propensity Score
Cholangiocarcinoma
Adjuvant Chemotherapy
Drug Therapy
Survival
3 Citations (Scopus)

Preclinical In Vitro and In Vivo Evidence of an Antitumor Effect of CX-4945, a Casein Kinase II Inhibitor, in Cholangiocarcinoma

Zakharia, K., Miyabe, K., Wang, Y., Wu, D., Moser, C. D., Borad, M. J. & Roberts, L. R., Jan 1 2019, In : Translational Oncology. 12, 1, p. 143-153 11 p.

Research output: Contribution to journalArticle

Casein Kinase II
Cholangiocarcinoma
gemcitabine
Cisplatin
Heterografts

Prognostic subclass of intrahepatic cholangiocarcinoma by integrative molecular–clinical analysis and potential targeted approach

Ahn, K. S., O’Brien, D., Kang, Y. N., Mounajjed, T., Kim, Y. H., Kim, T. S., Kocher, J-P., Allotey, L. K., Borad, M. J., Roberts, L. R. & Kang, K. J., Jan 1 2019, In : Hepatology International.

Research output: Contribution to journalArticle

Cholangiocarcinoma
RNA Sequence Analysis
gemcitabine
Pathology
Cholangitis

Rationale and design of the Hepatocellular carcinoma Early Detection Strategy study: A multi-center longitudinal initiative of the National Cancer Institute's Early Detection Research Network

Borges, E. A., Dai, J., Parikh, N. D., Schwartz, M., Nguyen, M. H., Roberts, L. R., Befeler, A. S., Srivastava, S., Rinaudo, J. A., Feng, Z., Marrero, J. A. & Reddy, K. R., Jan 1 2019, In : Contemporary Clinical Trials. 76, p. 49-54 6 p.

Research output: Contribution to journalArticle

National Cancer Institute (U.S.)
Hepatocellular Carcinoma
Research
Fibrosis
Databases
1 Citation (Scopus)

Single-dose neoadjuvant akt pathway inhibitor reduces growth of hepatocellular carcinoma after laser thermal ablation in small-animal model

Jondal, D. E., Thompson, S. M., Butters, K. A., Knudsen, B. E., Anderson, J. L., Roberts, L. R., Callstrom, M. R. & Woodrum, D. A., Jan 1 2019, In : Radiology. 292, 3, p. 752-759 8 p.

Research output: Contribution to journalArticle

Growth Inhibitors
Laser Therapy
Hepatocellular Carcinoma
1-Phosphatidylinositol 4-Kinase
Animal Models
Open Access
chemotherapy
Epithelial-Mesenchymal Transition
hepatoma
tumor
Fluorouracil
2018
420 Citations (Scopus)

AASLD guidelines for the treatment of hepatocellular carcinoma

Heimbach, J. K., Kulik, L. M., Finn, R. S., Sirlin, C. B., Abecassis, M. M., Roberts, L. R., Zhu, A. X., Murad, M. H. & Marrero, J. A., Jan 1 2018, In : Hepatology. 67, 1, p. 358-380 23 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Hepatocellular Carcinoma
Guidelines
40 Citations (Scopus)

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 690-705.e9

Research output: Contribution to journalArticle

Breast Neoplasms
Atlases
Long Noncoding RNA
Decision Trees
Genome

A model predicting short-term mortality in patients with advanced liver cirrhosis and concomitant infection

Li, Y., Chaiteerakij, R., Kwon, J. H., Jang, J. W., Lee, H. L., Cha, S., Ding, X. W., Thongprayoon, C., Ha, F. S., Nie, C. Y., Zhang, Q., Yang, Z., Giama, N. H., Roberts, L. R. & Han, T., Oct 1 2018, In : Medicine. 97, 41, p. e12758

Research output: Contribution to journalArticle

End Stage Liver Disease
ROC Curve
Liver Cirrhosis
Decision Trees
Mortality

An Enlarging Metastatic Calcified Liver Lesion of an Occult Melanoma

Mouchli, M. A., Kerr, S. E. & Roberts, L. R., Jun 18 2018, (Accepted/In press) In : Case Reports in Oncology. p. 388-391 4 p.

Research output: Contribution to journalArticle

Melanoma
Liver
Hemangioma
Liver Neoplasms
Blood Vessels
78 Citations (Scopus)

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 400-416.e11

Research output: Contribution to journalArticle

Atlases
Genes
Genome
Survival
Neoplasms
3 Citations (Scopus)

Anti-viral therapy is associated with improved survival but is underutilised in patients with hepatitis B virus-related hepatocellular carcinoma: real-world east and west experience

Chen, V. L., Yeh, M. L., Le, A. K., Jun, M., Saeed, W. K., Yang, J. D., Huang, C. F., Lee, H. Y., Tsai, P. C., Lee, M. H., Giama, N., Kim, N. G., Nguyen, P. P., Dang, H., Ali, H. A., Zhang, N., Huang, J. F., Dai, C. Y., Chuang, W. L., Roberts, L. R. & 4 others, Jun, D. W., Lim, Y. S., Yu, M. L. & Nguyen, M. H., Jul 1 2018, In : Alimentary Pharmacology and Therapeutics. 48, 1, p. 44-54 11 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Hepatocellular Carcinoma
Survival
Fibrosis
Therapeutics
24 Citations (Scopus)

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 386-399.e12

Research output: Contribution to journalArticle

Genes
Tumors
Neoplasms
Computational methods
Chromatin
7 Citations (Scopus)

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

The Cancer Genome Atlas Research Network, Oct 24 2018, In : Cell Systems. 7, 4, p. 422-437.e7

Research output: Contribution to journalArticle

Transforming Growth Factors
Neoplasms
Sequence Deletion
Genes
Gastrointestinal Neoplasms
gemcitabine
Cholangiocarcinoma
Cisplatin
Epidemiology
Survival
1 Citation (Scopus)

Association between treatment facility volume, therapy types and overall survival in patients with intrahepatic cholangiocarcinoma

Kommalapati, A., Tella, S. H., Goyal, G., Borad, M. J., Alberts, S. R., Roberts, L. R., Hubbard, J. M., Durgin, L., Cleary, S. & Mahipal, A., Jan 1 2018, (Accepted/In press) In : HPB.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Survival
Liver
Therapeutics
Insurance

Barriers in Hepatitis C Treatment in Somali Patients in the Direct Acting Antiviral Therapy Era

Elwir, S., Anugwom, C., Connor, E. K., Giama, N. H., Ndzengue, A., Menk, J., Mohamed, E. A., Roberts, L. R. & Hassan, M., Jan 1 2018, (Accepted/In press) In : Journal of the National Medical Association.

Research output: Contribution to journalArticle

Hepatitis C
Antiviral Agents
Hepacivirus
Therapeutics
Genotype
120 Citations (Scopus)

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

The Cancer Genome Atlas Network, Apr 5 2018, In : Cell. 173, 2, p. 291-304.e6

Research output: Contribution to journalArticle

Tumors
Tissue
Histology
Methylation
Oncology
2 Citations (Scopus)

Clinical Features Associated with Survival Outcome in African-American Patients with Hepatocellular Carcinoma

Estevez, J., Yang, J. D., Leong, J., Nguyen, P., Giama, N. H., Zhang, N., Ali, H. A., Lee, M. H., Cheung, R., Roberts, L. R., Schwartz, M. & Nguyen, M. H., Jan 1 2018, (Accepted/In press) In : American Journal of Gastroenterology.

Research output: Contribution to journalArticle

African Americans
Hepatocellular Carcinoma
Survival
Liver Neoplasms
Mortality
33 Citations (Scopus)

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 721-735.e8

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Genome
Chromosomal Instability
Rectum
33 Citations (Scopus)

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

The Cancer Genome Atlas Research Network, Aug 13 2018, In : Cancer Cell. 34, 2, p. 211-224.e6

Research output: Contribution to journalArticle

Alternative Splicing
Neoplasms
Exons
Exome
Peptides
134 Citations (Scopus)

Comprehensive Characterization of Cancer Driver Genes and Mutations

The MC3 Working Group & The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 371-385.e18

Research output: Contribution to journalArticle

Neoplasm Genes
Tumors
Genes
Mutation
Neoplasms
7 Citations (Scopus)

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

The Cancer Genome Atlas Research Network, Oct 30 2018, In : Cell Reports. 25, 5, p. 1304-1317.e5

Research output: Contribution to journalArticle

Genes
Neoplasms
Squamous Cell Neoplasms
Tumors
Atlases
137 Citations (Scopus)

Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases

Marrero, J. A., Kulik, L. M., Sirlin, C. B., Zhu, A. X., Finn, R. S., Abecassis, M. M., Roberts, L. R. & Heimbach, J. K., Aug 1 2018, In : Hepatology. 68, 2, p. 723-750 28 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
4 Citations (Scopus)

DNA methylation of telomere-related genes and cancer risk

Joyce, B. T., Zheng, Y., Nannini, D., Zhang, Z., Liu, L., Gao, T., Kocherginsky, M., Murphy, R., Yang, H., Achenbach, C. J., Roberts, L. R., Hoxha, M., Shen, J., Vokonas, P., Schwartz, J., Baccarelli, A. & Hou, L., Aug 1 2018, In : Cancer Prevention Research. 11, 8, p. 511-522 12 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Telomere
DNA Methylation
Neoplasms
Leukocytes
35 Citations (Scopus)

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

The Fusion Analysis Working Group & The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 227-238.e3

Research output: Contribution to journalArticle

Human Development
Phosphotransferases
Genes
Gene expression
Tumors
29 Citations (Scopus)

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 194-212.e6

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
MicroRNAs
Mutation
Epithelial Cells
Squamous Cell Neoplasms
41 Citations (Scopus)

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 676-689.e3

Research output: Contribution to journalArticle

Aneuploidy
Chromosomes
Neoplasms
Genome
Mutation Rate
69 Citations (Scopus)

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 239-254.e6

Research output: Contribution to journalArticle

DNA Repair-Deficiency Disorders
Atlases
DNA Damage
Repair
Genes
15 Citations (Scopus)

Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma

Nepal, C., O'Rourke, C. J., Oliveira, D. V. N. P., Taranta, A., Shema, S., Gautam, P., Calderaro, J., Barbour, A., Raggi, C., Wennerberg, K., Wang, X. W., Lautem, A., Roberts, L. R. & Andersen, J. B., Sep 1 2018, In : Hepatology. 68, 3, p. 949-963 15 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Drug Repositioning
Exome
Mutation
Dissection
131 Citations (Scopus)

Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study

The Polaris Observatory Collaborators, Jun 1 2018, In : The Lancet Gastroenterology and Hepatology. 3, 6, p. 383-403 21 p.

Research output: Contribution to journalArticle

Virus Diseases
Hepatitis B virus
Vaccination
Hepatitis B Surface Antigens
Mothers
4 Citations (Scopus)

Heat stress and hepatic laser thermal ablation induce hepatocellular carcinoma growth: Role of PI3K/mTOR/AKT Signaling

Jondal, D. E., Thompson, S. M., Butters, K. A., Knudsen, B. E., Anderson, J. L., Carter, R. E., Roberts, L. R., Callstrom, M. R. & Woodrum, D. A., Sep 1 2018, In : Radiology. 288, 3, p. 730-738 9 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Laser Therapy
Sirolimus
Hepatocellular Carcinoma
Hot Temperature
1 Citation (Scopus)

Heat stress and thermal ablation induce local expression of nerve growth factor inducible (VGF) in hepatocytes and hepatocellular carcinoma: Preclinical and clinical studies

Thompson, S. M., Jondal, D. E., Butters, K. A., Knudsen, B. E., Anderson, J. L., Roberts, L. R., Callstrom, M. R. & Woodrum, D. A., Jan 1 2018, In : Gene Expression. 19, 1, p. 37-47 11 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Hepatocytes
Hepatocellular Carcinoma
Hot Temperature
Liver
10 Citations (Scopus)

Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2

Kostallari, E., Hirsova, P., Prasnicka, A., Verma, V. K., Yaqoob, U., Wongjarupong, N., Roberts, L. R. & Shah, V., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor alpha Receptor
Hepatic Stellate Cells
Liver Cirrhosis
src Homology Domains
Phosphoric Monoester Hydrolases
Gene transfer
Horizontal Gene Transfer
Workflow
Sequencing
Work Flow
2 Citations (Scopus)

Hypothyroidism is associated with worse outcomes of hepatocellular carcinoma patients after liver transplantation

Zhang, N., Jin, W., Zhou, S., Yang, J. D., Harmsen, W. S., Giama, N. H., Wongjarupong, N., Heimbach, J. K., Watt, K. D., Malhi, H. M., Therneau, T. M. & Roberts, L. R., Jan 1 2018, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

Hypothyroidism
Liver Transplantation
Hepatocellular Carcinoma
Survival
Recurrence
8 Citations (Scopus)

Impact of surveillance for hepatocellular carcinoma on survival in patients with compensated cirrhosis

Yang, J. D., Mannalithara, A., Piscitello, A. J., Kisiel, J. B., Gores, G. J., Roberts, L. R. & Kim, W. R., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Fibrosis
Survival
Liver
Mortality

Insights into the interplay between KIR gene frequencies and chronic HBV infection in Burkina Faso

Sorgho, P. A., Martinson, J. J., Djigma, F. W., Yonli, A. T., Nagalo, B., Compaore, T. R., Obiri-Yeboah, D., Diarra, B., Sombie, H. K., Zongo, A. W., Ouattara, A. K., Soubeiga, S. T. R., Traore, L., Roberts, L. R. & Simpore, J., Jan 1 2018, In : Mediterranean Journal of Hematology and Infectious Diseases. 10, 1, e2018060.

Research output: Contribution to journalArticle

Open Access
KIR Receptors
Burkina Faso
Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
9 Citations (Scopus)

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 213-226.e3

Research output: Contribution to journalArticle

Ubiquitin
Genes
Neoplasms
Tumors
Amplification
2 Citations (Scopus)
Yttrium
Microspheres
Glass
Hepatocellular Carcinoma
Randomized Controlled Trials
70 Citations (Scopus)

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 706-720.e9

Research output: Contribution to journalArticle

Long Noncoding RNA
Epigenomics
Cell Cycle
Genes
Neoplasms