Lewis Rowland Roberts, MB, ChB, PhD

  • 19948 Citations
  • 78 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2018

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

The Cancer Genome Atlas Research Network, Oct 24 2018, In : Cell Systems. 7, 4, p. 422-437.e7

Research output: Contribution to journalArticle

29 Scopus citations

Barriers in Hepatitis C Treatment in Somali Patients in the Direct Acting Antiviral Therapy Era

Elwir, S., Anugwom, C., Connor, E. K., Giama, N. H., Ndzengue, A., Menk, J., Mohamed, E. A., Roberts, L. R. & Hassan, M., Jan 1 2018, (Accepted/In press) In : Journal of the National Medical Association.

Research output: Contribution to journalArticle

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

The Cancer Genome Atlas Network, Apr 5 2018, In : Cell. 173, 2, p. 291-304.e6

Research output: Contribution to journalArticle

282 Scopus citations

Clinical Features Associated with Survival Outcome in African-American Patients with Hepatocellular Carcinoma

Estevez, J., Yang, J. D., Leong, J., Nguyen, P., Giama, N. H., Zhang, N., Ali, H. A., Lee, M. H., Cheung, R., Roberts, L. R., Schwartz, M. & Nguyen, M. H., Jan 1 2018, (Accepted/In press) In : American Journal of Gastroenterology.

Research output: Contribution to journalArticle

4 Scopus citations

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 721-735.e8

Research output: Contribution to journalArticle

80 Scopus citations

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

The Cancer Genome Atlas Research Network, Aug 13 2018, In : Cancer cell. 34, 2, p. 211-224.e6

Research output: Contribution to journalArticle

114 Scopus citations

Comprehensive Characterization of Cancer Driver Genes and Mutations

The MC3 Working Group & The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 371-385.e18

Research output: Contribution to journalArticle

329 Scopus citations

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

The Cancer Genome Atlas Research Network, Oct 30 2018, In : Cell reports. 25, 5, p. 1304-1317.e5

Research output: Contribution to journalArticle

38 Scopus citations

Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases

Marrero, J. A., Kulik, L. M., Sirlin, C. B., Zhu, A. X., Finn, R. S., Abecassis, M. M., Roberts, L. R. & Heimbach, J., Aug 1 2018, In : Hepatology. 68, 2, p. 723-750 28 p.

Research output: Contribution to journalArticle

444 Scopus citations

DNA methylation of telomere-related genes and cancer risk

Joyce, B. T., Zheng, Y., Nannini, D., Zhang, Z., Liu, L., Gao, T., Kocherginsky, M., Murphy, R., Yang, H., Achenbach, C. J., Roberts, L. R., Hoxha, M., Shen, J., Vokonas, P., Schwartz, J., Baccarelli, A. & Hou, L., Aug 2018, In : Cancer Prevention Research. 11, 8, p. 511-522 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

The Fusion Analysis Working Group & The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 227-238.e3

Research output: Contribution to journalArticle

102 Scopus citations

Erratum: Comprehensive Characterization of Cancer Driver Genes and Mutations (ARTICLE (2018) 173(2) (371–385), (S009286741830237X), (10.1016/j.cell.2018.02.060))

The MC3 Working Group & The Cancer Genome Atlas Research Network, Aug 9 2018, In : Cell. 174, 4, p. 1034-1035 2 p.

Research output: Contribution to journalComment/debate

63 Scopus citations
28 Scopus citations

Gastrointestinal and Extra-Intestinal Manifestations of IgG4–Related Disease

Miyabe, K., Zen, Y., Cornell, L. D., Rajagopalan, G. D., Chowdhary, V. R., Roberts, L. R. & Chari, S. T., Oct 1 2018, In : Gastroenterology. 155, 4, p. 990-1003.e1

Research output: Contribution to journalReview article

13 Scopus citations

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 194-212.e6

Research output: Contribution to journalArticle

57 Scopus citations

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 676-689.e3

Research output: Contribution to journalArticle

104 Scopus citations

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 239-254.e6

Research output: Contribution to journalArticle

142 Scopus citations

Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma

Nepal, C., O'Rourke, C. J., Oliveira, D. V. N. P., Taranta, A., Shema, S., Gautam, P., Calderaro, J., Barbour, A., Raggi, C., Wennerberg, K., Wang, X. W., Lautem, A., Roberts, L. R. & Andersen, J. B., Sep 2018, In : Hepatology. 68, 3, p. 949-963 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study

The Polaris Observatory Collaborators, Jun 1 2018, In : The Lancet Gastroenterology and Hepatology. 3, 6, p. 383-403 21 p.

Research output: Contribution to journalArticle

259 Scopus citations

Heat stress and hepatic laser thermal ablation induce hepatocellular carcinoma growth: Role of PI3K/mTOR/AKT Signaling

Jondal, D. E., Thompson, S. M., Butters, K. A., Knudsen, B. E., Anderson, J. L., Carter, R. E., Roberts, L. R., Callstrom, M. R. & Woodrum, D. A., Sep 1 2018, In : Radiology. 288, 3, p. 730-738 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Heat stress and thermal ablation induce local expression of nerve growth factor inducible (VGF) in hepatocytes and hepatocellular carcinoma: Preclinical and clinical studies

Thompson, S. M., Jondal, D. E., Butters, K. A., Knudsen, B. E., Anderson, J. L., Roberts, L. R., Callstrom, M. R. & Woodrum, D. A., Jan 1 2018, In : Gene Expression. 19, 1, p. 37-47 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2

Kostallari, E., Hirsova, P., Prasnicka, A., Verma, V. K., Yaqoob, U., Wongjarupong, N., Roberts, L. R. & Shah, V., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

17 Scopus citations

Hepatocellular carcinoma: Epidemiology, pathogenesis and surveillance - implications for sub-Saharan Africa

Zakharia, K., Luther, C. A., Alsabbak, H. & Roberts, L. R., Aug 8 2018, In : South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 108, 8, p. 35-40 6 p.

Research output: Contribution to journalReview article

4 Scopus citations

Hepatocellular carcinoma in South America: Evaluation of risk factors, demographics and therapy

Debes, J. D., Chan, A. J., Balderramo, D., Kikuchi, L., Gonzalez Ballerga, E., Prieto, J. E., Tapias, M., Idrovo, V., Davalos, M. B., Cairo, F., Barreyro, F. J., Paredes, S., Hernandez, N., Avendaño, K., Diaz Ferrer, J., Yang, J. D., Carrera, E., Garcia, J. A., Mattos, A. Z., Hirsch, B. S. & 3 others, Gonçalves, P. T., Carrilho, F. J. & Roberts, L. R., Jan 2018, In : Liver International. 38, 1, p. 136-143 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
1 Scopus citations

Hypothyroidism is associated with worse outcomes of hepatocellular carcinoma patients after liver transplantation

Zhang, N., Jin, W., Zhou, S., Yang, J. D., Harmsen, W. S., Giama, N. H., Wongjarupong, N., Heimbach, J., Watt, K. D., Malhi, H., Therneau, T. M. & Roberts, L. R., Jan 1 2018, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

4 Scopus citations

Imaging for the diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis

Roberts, L. R., Sirlin, C. B., Zaiem, F., Almasri, J., Prokop, L. J., Heimbach, J. K., Murad, M. H. & Mohammed, K., Jan 1 2018, In : Hepatology. 67, 1, p. 401-421 21 p.

Research output: Contribution to journalReview article

74 Scopus citations

Impact of surveillance for hepatocellular carcinoma on survival in patients with compensated cirrhosis

Yang, J. D., Mannalithara, A., Piscitello, A. J., Kisiel, J. B., Gores, G. J., Roberts, L. R. & Kim, W. R., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

16 Scopus citations

Insights into the interplay between KIR gene frequencies and chronic HBV infection in Burkina Faso

Sorgho, P. A., Martinson, J. J., Djigma, F. W., Yonli, A. T., Nagalo, B. M., Compaore, T. R., Obiri-Yeboah, D., Diarra, B., Sombie, H. K., Zongo, A. W., Ouattara, A. K., Soubeiga, S. T. R., Traore, L., Roberts, L. R. & Simpore, J., 2018, In : Mediterranean Journal of Hematology and Infectious Diseases. 10, 1, e2018060.

Research output: Contribution to journalArticle

Open Access

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 213-226.e3

Research output: Contribution to journalArticle

23 Scopus citations
6 Scopus citations

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 706-720.e9

Research output: Contribution to journalArticle

138 Scopus citations

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 172-180.e3

Research output: Contribution to journalArticle

29 Scopus citations

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 338-354.e15

Research output: Contribution to journalArticle

152 Scopus citations

Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models

Wongjarupong, N., Negron-Ocasio, G. M., Chaiteerakij, R., Addissie, B. D., Mohamed, E. A., Mara, K. C., Harmsen, W. S., Theobald, J. P., Peters, B. E., Balsanek, J. G., Ward, M. M., Giama, N. H., Venkatesh, S. K., Harnois, D. M., Charlton, M. R., Yamada, H., Algeciras-Schimnich, A., Snyder, M. R., Therneau, T. M. & Roberts, L. R., Mar 28 2018, In : World journal of gastroenterology. 24, 12, p. 1321-1331 11 p.

Research output: Contribution to journalReview article

5 Scopus citations

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 255-269.e4

Research output: Contribution to journalArticle

36 Scopus citations

Molecular testing for the clinical diagnosis of fibrolamellar carcinoma

Graham, R. P., Yeh, M. M., Lam-Himlin, D., Roberts, L. R., Terracciano, L., Cruise, M. W., Greipp, P. T., Zreik, R. T., Jain, D., Zaid, N., Salaria, S. N., Jin, L., Wang, X., Rustin, J. G., Kerr, S. E., Sukov, W. R., Solomon, D. A., Kakar, S., Waterhouse, E., Gill, R. M. & 8 others, Ferrell, L., Alves, V. A., Nart, D., Yilmaz, F., Roessler, S., Longerich, T., Schirmacher, P. & Torbenson, M. S., Jan 1 2018, In : Modern Pathology. 31, 1, p. 141-149 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Non-alcoholic fatty liver disease-associated hepatocellular carcinoma: Effect of hepatic steatosis on major hepatocellular carcinoma features at MRI

Thompson, S. M., Garg, I., Ehman, E. C., Sheedy, S., Bookwalter, C. A., Carter, R. E., Roberts, L. R. & Venkatesh, S. K., Jan 1 2018, In : British Journal of Radiology. 91, 1092, 20180345.

Research output: Contribution to journalArticle

7 Scopus citations

Oncogenic Signaling Pathways in The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 321-337.e10

Research output: Contribution to journalArticle

367 Scopus citations

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

The Cancer Genome Atlas Network, Mar 28 2018, In : Cell Systems. 6, 3, p. 282-300.e2

Research output: Contribution to journalArticle

59 Scopus citations

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 297-312.e12

Research output: Contribution to journalArticle

89 Scopus citations

Pathogenic Germline Variants in 10,389 Adult Cancers

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 355-370.e14

Research output: Contribution to journalArticle

148 Scopus citations

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 305-320.e10

Research output: Contribution to journalArticle

76 Scopus citations

Prevalent hepatitis B surface antigen among first-time blood donors in Gabon

Eko Mba, J. M., Bisseye, C., Ntsame Ndong, J. M., Mombo, L. E., Bengone, C., Migolet, G. M., Batchi, B. M., Kosiorek, H. E., Butterfield, R. J., Roberts, L. R., Borad, M. J. & Nagalo, B. M., Apr 2018, In : PloS one. 13, 4, e0194285.

Research output: Contribution to journalArticle

4 Scopus citations

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

MC3 Working Group & The Cancer Genome Atlas Research Network, Mar 28 2018, In : Cell Systems. 6, 3, p. 271-281.e7

Research output: Contribution to journalArticle

111 Scopus citations

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 282-296.e4

Research output: Contribution to journalArticle

78 Scopus citations

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 181-193.e7

Research output: Contribution to journalArticle

110 Scopus citations

Systematic Analysis of Splice-Site-Creating Mutations in Cancer

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 270-281.e3

Research output: Contribution to journalArticle

46 Scopus citations

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 313-326.e5

Research output: Contribution to journalArticle

113 Scopus citations