Lewis Rowland Roberts, MB, ChB, PhD

  • 19948 Citations
  • 78 Scopus h-Index
1991 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

{A figure is presented}The Utility of Lens Culinaris Agglutinin-Reactive α-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma: Evaluation in a United States Referral Population

Leerapun, A., Suravarapu, S. V., Bida, J. P., Clark, R. J., Sanders, E. L., Mettler, T. A., Stadheim, L. M., Aderca, I., Moser, C. D., Nagorney, D. M., LaRusso, N. F., de Groen, P. C., Menon, K. V. N., Lazaridis, K. N., Gores, G. J., Charlton, M. R., Roberts, R. O., Therneau, T. M., Katzmann, J. A. & Roberts, L. R., Mar 1 2007, In : Clinical Gastroenterology and Hepatology. 5, 3, p. 394-402 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

67-Year-old man with hepatitis C infection and abdominal distention

Choong, N. W. W., Asfandiyar, S. & Roberts, L. R., Feb 1 2003, In : Mayo Clinic proceedings. 78, 2, p. 217-220 4 p.

Research output: Contribution to journalArticle

Open Access

AASLD guidelines for the treatment of hepatocellular carcinoma

Heimbach, J. K., Kulik, L. M., Finn, R. S., Sirlin, C. B., Abecassis, M. M., Roberts, L. R., Zhu, A. X., Murad, M. H. & Marrero, J. A., Jan 2018, In : Hepatology. 67, 1, p. 358-380 23 p.

Research output: Contribution to journalArticle

731 Scopus citations

Abrogation of MAPK and Akt signaling by AEE788 synergistically potentiates histone deacetylase inhibitor-induced apoptosis through reactive oxygen species generation

Yu, C., Friday, B. B., Lai, J. P., McCollum, A., Atadja, P., Roberts, L. R. & Adjei, A. A., Feb 15 2007, In : Clinical Cancer Research. 13, 4, p. 1140-1148 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

A comparison of routine cytology and fluorescence in situ hybridization for the detection of malignant bile duct strictures

Kipp, B. R., Stadheim, L. M., Halling, S. A., Pochron, N. L., Harmsen, S., Nagorney, D. M., Sebo, T. J., Therneau, T. M., Gores, G. J., De Groen, P. C., Baron, T. H., Levy, M. J., Halling, K. C. & Roberts, L. R., Sep 1 2004, In : American Journal of Gastroenterology. 99, 9, p. 1675-1681 7 p.

Research output: Contribution to journalArticle

264 Scopus citations

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 690-705.e9

Research output: Contribution to journalArticle

102 Scopus citations

Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

Nakamura, I., Fernandez-Barrena, M. G., Ortiz-Ruiz, M. C., Almada, L. L., Hu, C., Elsawa, S. F., Mills, L. D., Romecin, P. A., Gulaid, K. H., Moser, C. D., Han, J. J., Vrabel, A., Hanse, E. A., Akogyeram, N. A., Albrecht, J. H., Monga, S. P. S., Sanderson, S. O., Prieto, J., Roberts, L. R. & Fernandez-Zapico, M. E., Jul 19 2013, In : Journal of Biological Chemistry. 288, 29, p. 21389-21398 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma

Dhanasekaran, R., Nakamura, I., Hu, C., Chen, G., Oseini, A. M., Seven, E. S., Miamen, A. G., Moser, C. D., Zhou, W., van Kuppevelt, T. H., van Deursen, J. M., Mounajjed, T., Fernandez-Zapico, M. E. & Roberts, L. R., Apr 1 2015, In : Hepatology. 61, 4, p. 1269-1283 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo

Lai, J. P., Sandhu, D. S., Moser, C. D., Cazanave, S. C., Oseini, A. M., Shire, A. M., Shridhar, V., Sanderson, S. O. & Roberts, L. R., Jun 2009, In : Journal of hepatology. 50, 6, p. 1112-1121 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Advanced Cytologic Techniques for the Detection of Malignant Pancreatobiliary Strictures

Moreno Luna, L. E., Kipp, B., Halling, K. C., Sebo, T. J., Kremers, W. K., Roberts, L. R., Barr Fritcher, E. G., Levy, M. J. & Gores, G. J., Oct 2006, In : Gastroenterology. 131, 4, p. 1064-1072 9 p.

Research output: Contribution to journalArticle

217 Scopus citations

Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B

the Hepatitis B Research Network (HBRN), Jul 2019, In : Journal of viral hepatitis. 26, 7, p. 856-865 10 p.

Research output: Contribution to journalArticle

A global view of hepatocellular carcinoma: trends, risk, prevention and management

Yang, J. D., Hainaut, P., Gores, G. J., Amadou, A., Plymoth, A. & Roberts, L. R., Jan 1 2019, (Accepted/In press) In : Nature Reviews Gastroenterology and Hepatology.

Research output: Contribution to journalReview article

105 Scopus citations

A major estrogen-regulated protein secreted from the liver of xenopus Laevis is a member of the serpin superfamily: Nucleotide sequence of cDNA and hormonal Induction of mRNA

Holland, L. J., Suksang, C., Wall, A. A., Roberts, L. R., Moser, D. R. & Bhattacharya, A., Apr 5 1992, In : Journal of Biological Chemistry. 267, 10, p. 7053-7059 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

A model predicting short-term mortality in patients with advanced liver cirrhosis and concomitant infection

Li, Y., Chaiteerakij, R., Kwon, J. H., Jang, J. W., Lee, H. L., Cha, S., Ding, X. W., Thongprayoon, C., Ha, F. S., Nie, C. Y., Zhang, Q., Yang, Z., Giama, N. H., Roberts, L. R. & Han, T., Oct 1 2018, In : Medicine (United States). 97, 41, e12758.

Research output: Contribution to journalArticle

1 Scopus citations

A Moveable Feast

Camilleri, M., Sandborn, W. J., Kolars, J. C., Murray, J. A., Poterucha, J. J., Roberts, L., Sinicrope, F. A. & Wang, K. K., Jun 1 2007, In : Clinical Gastroenterology and Hepatology. 5, 6, p. 646-647 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

A Multivariable Model Using Advanced Cytologic Methods for the Evaluation of Indeterminate Pancreatobiliary Strictures

Barr Fritcher, E. G., Kipp, B. R., Halling, K. C., Oberg, T. N., Bryant, S. C., Tarrell, R. F., Gores, G. J., Levy, M. J., Clayton, A. C., Sebo, T. J. & Roberts, L. R., Jun 2009, In : Gastroenterology. 136, 7, p. 2180-2186 7 p.

Research output: Contribution to journalArticle

116 Scopus citations

An assessment of chromosomal alterations detected by fluorescence in situ hybridization and p16 expression in sporadic and primary sclerosing cholangitis-associated cholangiocarcinomas

DeHaan, R. D., Kipp, B. R., Smyrk, T. C., Abraham, S. C., Roberts, L. R. & Halling, K. C., Mar 1 2007, In : Human Pathology. 38, 3, p. 491-499 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

A necrotic liver mass

Sweetser, S., Roberts, L. R. & Medeiros, F., Sep 2010, In : Gastroenterology. 139, 3, p. e6-e7

Research output: Contribution to journalArticle

An Enlarging Metastatic Calcified Liver Lesion of an Occult Melanoma

Mouchli, M. A., Kerr, S. E. & Roberts, L., May 1 2018, In : Case Reports in Oncology. 11, 2, p. 388-391 4 p.

Research output: Contribution to journalArticle

A new, effective and high-yield approach for identifying liver tumor suppressors

Olgun, E. & Roberts, L. R., Feb 26 2009, In : Genome medicine. 1, 2, gm26.

Research output: Contribution to journalShort survey

1 Scopus citations

A new clinically based staging system for perihilar cholangiocarcinoma

Chaiteerakij, R., Harmsen, W. S., Marrero, C. R., Aboelsoud, M. M., Ndzengue, A., Kaiya, J., Therneau, T. M., Sanchez, W., Gores, G. J. & Roberts, L. R., Dec 11 2014, In : American Journal of Gastroenterology. 109, 12, p. 1881-1890 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice

Koh, M. Y., Gagea, M., Sargis, T., Lemos, R., Grandjean, G., Charbono, A., Bekiaris, V., Sedy, J., Kiriakova, G., Liu, X., Roberts, L. R., Ware, C. & Powis, G., May 1 2016, In : Hepatology. 63, 5, p. 1576-1591 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 400-416.e11

Research output: Contribution to journalArticle

281 Scopus citations

An Optimized Set of Fluorescence in Situ Hybridization Probes for Detection of Pancreatobiliary Tract Cancer in Cytology Brush Samples

Barr Fritcher, E. G., Voss, J. S., Brankley, S. M., Campion, M. B., Jenkins, S. M., Keeney, M. E., Henry, M. R., Kerr, S. M., Chaiteerakij, R., Pestova, E. V., Clayton, A. C., Zhang, J., Roberts, L. R., Gores, G. J., Halling, K. C. & Kipp, B. R., Dec 1 2015, In : Gastroenterology. 149, 7, p. 1813-1824e1

Research output: Contribution to journalArticle

38 Scopus citations

A novel clinically based staging system for gallbladder cancer

Yadav, S., Tella, S. H., Kommalapati, A., Mara, K., Prasai, K., Mady, M. H., Hassan, M., Smoot, R. L., Cleary, S. P., Truty, M. J., Roberts, L. R. & Mahipal, A., 2020, In : JNCCN Journal of the National Comprehensive Cancer Network. 18, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

Lee, J. S., Heo, J., Libbrecht, L., Chu, I. S., Kaposi-Novak, P., Calvisi, D. F., Mikaelyan, A., Roberts, L. R., Demetris, A. J., Sun, Z., Nevens, F., Roskams, T. & Thorgeirsson, S. S., Apr 1 2006, In : Nature Medicine. 12, 4, p. 410-416 7 p.

Research output: Contribution to journalArticle

688 Scopus citations

Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151

Kim, J. H., Badawi, M., Park, J. K., Jiang, J., Mo, X., Roberts, L. R. & Schmittgen, T. D., Nov 2016, In : International journal of oncology. 49, 5, p. 2037-2045 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Antitumor effect of FGFR inhibitors on a novel cholangiocarcinoma patient derived xenograft mouse model endogenously expressing an FGFR2-CCDC6 fusion protein

Wang, Y., Ding, X., Wang, S., Moser, C. D., Shaleh, H. M., Mohamed, E. A., Chaiteerakij, R., Allotey, L. K., Chen, G., Miyabe, K., McNulty, M. S., Ndzengue, A., Barr Fritcher, E. G., Knudson, R. A., Greipp, P. T., Clark, K. J., Torbenson, M. S., Kipp, B. R., Zhou, J., Barrett, M. T. & 4 others, Gustafson, M. P., Alberts, S. R., Borad, M. J. & Roberts, L. R., Sep 28 2016, In : Cancer Letters. 380, 1, p. 163-173 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells

Ding, X., Chaiteerakij, R., Moser, C. D., Shaleh, H., Boakye, J., Chen, G., Ndzengue, A., Li, Y., Zhou, Y., Huang, S., Sinicrope, F. A., Zou, X., Thomas, M. B., Smith, C. D. & Roberts, L. R., Apr 12 2016, In : Oncotarget. 7, 15, p. 20080-20092 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Anti-viral therapy is associated with improved survival but is underutilised in patients with hepatitis B virus-related hepatocellular carcinoma: real-world east and west experience

Chen, V. L., Yeh, M. L., Le, A. K., Jun, M., Saeed, W. K., Yang, J. D., Huang, C. F., Lee, H. Y., Tsai, P. C., Lee, M. H., Giama, N., Kim, N. G., Nguyen, P. P., Dang, H., Ali, H. A., Zhang, N., Huang, J. F., Dai, C. Y., Chuang, W. L., Roberts, L. R. & 4 others, Jun, D. W., Lim, Y. S., Yu, M. L. & Nguyen, M. H., Jul 1 2018, In : Alimentary Pharmacology and Therapeutics. 48, 1, p. 44-54 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 386-399.e12

Research output: Contribution to journalArticle

52 Scopus citations

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

The Cancer Genome Atlas Research Network, Oct 24 2018, In : Cell Systems. 7, 4, p. 422-437.e7

Research output: Contribution to journalArticle

29 Scopus citations

A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation

Chien, J., Narita, K., Rattan, R., Giri, S., Shridhar, R., Staub, J., Beleford, D., Lai, J., Roberts, L. R., Molina, J., Kaufmann, S. H., Prendergast, G. C. & Shridhar, V., Dec 11 2008, In : Oncogene. 27, 58, p. 7223-7234 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

AS30D model of hepatocellular carcinoma: Tumorigenicity and preliminary characterization by imaging, histopathology, and immunohistochemistry

Thompson, S. M., Callstrom, M. R., Knudsen, B., Anderson, J. L., Butters, K. A., Grande, J. P., Roberts, L. R. & Woodrum, D. A., Feb 1 2013, In : Cardiovascular and Interventional Radiology. 36, 1, p. 198-203 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Ascites and hepatorenal syndrome: Pathophysiology and management

Roberts, L. R. & Kamath, P. S., Jan 1 1996, In : Mayo Clinic proceedings. 71, 9, p. 874-881 8 p.

Research output: Contribution to journalReview article

32 Scopus citations

Aspirin use and the risk of cholangiocarcinoma

Choi, J., Ghoz, H. M., Peeraphatdit, T., Baichoo, E., Addissie, B. D., Harmsen, W. S., Therneau, T. M., Olson, J. E., Chaiteerakij, R. & Roberts, L. R., 2016, In : Hepatology. 64, 3, p. 785-796 12 p.

Research output: Contribution to journalArticle

36 Scopus citations
4 Scopus citations

Association between treatment facility volume, therapy types and overall survival in patients with intrahepatic cholangiocarcinoma

Kommalapati, A., Tella, S. H., Goyal, G., Borad, M., Alberts, S. R., Roberts, L., Hubbard, J. M., Durgin, L., Cleary, S. & Mahipal, A., Mar 2019, In : HPB. 21, 3, p. 379-386 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Association between variants in inflammation and cancer-associated genes and risk and survival of cholangiocarcinoma

Chaiteerakij, R., Juran, B. D., Aboelsoud, M. M., Harmsen, W. S., Moser, C. D., Giama, N. H., Allotey, L. K., Mettler, T. A., Baichoo, E., Zhang, X., Therneau, T. M., Lazaridis, K. N. & Roberts, L. R., Oct 1 2015, In : Cancer Medicine. 4, 10, p. 1599-1602 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Association of microRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival

Jiang, J., Gusev, Y., Aderca, I., Mettler, T. A., Nagorney, D. M., Brackett, D. J., Roberts, L. R. & Schmittgen, T. D., Jan 15 2008, In : Clinical Cancer Research. 14, 2, p. 419-427 9 p.

Research output: Contribution to journalArticle

443 Scopus citations

Barriers in Hepatitis C Treatment in Somali Patients in the Direct Acting Antiviral Therapy Era

Elwir, S., Anugwom, C., Connor, E. K., Giama, N. H., Ndzengue, A., Menk, J., Mohamed, E. A., Roberts, L. R. & Hassan, M., Jan 1 2018, (Accepted/In press) In : Journal of the National Medical Association.

Research output: Contribution to journalArticle

Biliary tract cancers: Epidemiology, molecular pathogenesis and genetic risk associations

Marcano-Bonilla, L., Mohamed, E. A., Mounajjed, T. & Roberts, L. R., 2016, In : Chinese Clinical Oncology. 5, 5

Research output: Contribution to journalReview article

37 Scopus citations

Biliary tract cancers in olmsted county, Minnesota, 1976-2008

Yang, J. D., Kim, B., Sanderson, S. O., Sauver, J. S., Yawn, B. P., Larson, J. J., Therneau, T. M., Roberts, L. R., Gores, G. J. & Kim, W. R., Aug 1 2012, In : American Journal of Gastroenterology. 107, 8, p. 1256-1262 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Biomarkers for hepatocellular carcinoma

Roberts, L. R., 2016, In : Clinical Advances in Hematology and Oncology. 14, 4, p. 223-226 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Biomarkers for hepatocellular carcinoma

Roberts, L. R., Apr 1 2016, In : Gastroenterology and Hepatology. 12, 4, p. 252-255 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Biphenotypic hepatic tumors: imaging findings and review of literature

Wells, M., Venkatesh, S. K., Chandan, V. S., Fidler, J. L., Fletcher, J. G., Johnson, G. B., Hough, D. M. & Roberts, L. R., May 8 2015, (Accepted/In press) In : Abdominal Imaging.

Research output: Contribution to journalArticle

19 Scopus citations

Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling

Nakamura, I., Zakharia, K., Banini, B. A., Mikhail, D. S., Kim, T. H., Yang, J. D., Moser, C. D., Shaleh, H. M., Thornburgh, S. R., Walters, I. & Roberts, L. R., Apr 7 2014, In : PloS one. 9, 4, e92273.

Research output: Contribution to journalArticle

34 Scopus citations

Casting a wider net: Improving access to medical literature in developing countries

Roberts, L. R., Missen, C. & Grimes, G. C., Jul 2007, In : Mayo Clinic proceedings. 82, 7, p. 846-848 3 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes

Roberts, L. R., Kurosawa, H., Bronk, S. F., Fesmier, P. J., Agellon, L. B., Leung, Y., Mao, F. & Gores, G. J., Jan 1 1997, In : Gastroenterology. 113, 5, p. 1714-1726 13 p.

Research output: Contribution to journalArticle

154 Scopus citations