Lewis Rowland Roberts, MB, ChB, PhD

  • 19948 Citations
  • 78 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2007

Preliminary experience comparing routine cytology results with the composite results of digital image analysis and fluorescence in situ hybridization in patients undergoing EUS-guided FNA

Levy, M. J., Clain, J. E., Clayton, A., Halling, K. C., Kipp, B. R., Rajan, E., Roberts, L. R., Root, R. M., Sebo, T. J., Topazian, M. D., Wang, K. K., Wiersema, M. J. & Gores, G. J., Sep 1 2007, In : Gastrointestinal endoscopy. 66, 3, p. 483-490 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Treatment options for hepatobiliary and pancreatic cancer

Alberts, S. R., Gores, G. J., Kim, G. P., Roberts, L. R., Kendrick, M. L., Rosen, C. B., Chari, S. T. & Martenson, J. A., May 2007, In : Mayo Clinic proceedings. 82, 5, p. 628-637 10 p.

Research output: Contribution to journalArticle

48 Scopus citations
2006

Advanced Cytologic Techniques for the Detection of Malignant Pancreatobiliary Strictures

Moreno Luna, L. E., Kipp, B., Halling, K. C., Sebo, T. J., Kremers, W. K., Roberts, L. R., Barr Fritcher, E. G., Levy, M. J. & Gores, G. J., Oct 2006, In : Gastroenterology. 131, 4, p. 1064-1072 9 p.

Research output: Contribution to journalArticle

217 Scopus citations

A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

Lee, J. S., Heo, J., Libbrecht, L., Chu, I. S., Kaposi-Novak, P., Calvisi, D. F., Mikaelyan, A., Roberts, L. R., Demetris, A. J., Sun, Z., Nevens, F., Roskams, T. & Thorgeirsson, S. S., Apr 1 2006, In : Nature Medicine. 12, 4, p. 410-416 7 p.

Research output: Contribution to journalArticle

688 Scopus citations
89 Scopus citations

Emerging drugs for hepatocellular carcinoma

Roberts, L. R. & Gores, G. J., Sep 1 2006, In : Expert Opinion on Emerging Drugs. 11, 3, p. 469-487 19 p.

Research output: Contribution to journalReview article

39 Scopus citations

Fiducial markers for MR histological correlation in ex vivo or short-term in vivo animal experiments: A screening study

Rouvière, O., Reynolds, C., Le, Y., Lai, J., Roberts, L. R., Felmlee, J. P. & Ehman, R. L., Jan 2006, In : Journal of Magnetic Resonance Imaging. 23, 1, p. 50-59 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Magnetic resonance elastography assesment of focused ultrasound surgery in cancer models - A pilot study

Primak, S. V., Glaser, K. J., Lai, J., Rossman, P. J., Le, Y., Reynolds, C. A., Roberts, L. R., Felmlee, J. P. & Ehman, R. L., 2006, Proceedings of 2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 - Bioengineering Division. American Society of Mechanical Engineers (ASME), (American Society of Mechanical Engineers, Bioengineering Division (Publication) BED).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Molecular targets for therapy of hepatitis B virus-induced hepatocellular carcinoma

Tharayil, V. S. & Roberts, L. R., Dec 1 2006, In : Minerva Gastroenterologica e Dietologica. 52, 4, p. 387-406 20 p.

Research output: Contribution to journalArticle

1 Scopus citations

MYH Y165C and G382D mutations in hepatocellular carcinoma and cholangiocarcinoma patients

Baudhuin, L. M., Roberts, L. R., Enders, F. T. B., Swanson, R. L., Mettler, T. A., Aderca, I., Stadheim, L. M. & Highsmith, W. E., Mar 1 2006, In : Journal of Cancer Research and Clinical Oncology. 132, 3, p. 159-162 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Study of shear wave displacement change measured by 1D MRE during focused ultrasound treatment: Preliminary study

Le, Y., Glaser, K., Romano, A., Manduca, A., Lai, J., Roberts, L. R., Primak, S., Ehman, R. & Felmlee, J. P., May 8 2006, THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound. p. 186-190 5 p. (AIP Conference Proceedings; vol. 829).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

SULF1 Inhibits Tumor Growth and Potentiates the Effects of Histone Deacetylase Inhibitors in Hepatocellular Carcinoma

Lai, J. P., Yu, C., Moser, C. D., Aderca, I., Han, T., Garvey, T. D., Murphy, L. M., Garrity-Park, M. M., Shridhar, V., Adjei, A. A. & Roberts, L. R., Jul 2006, In : Gastroenterology. 130, 7, p. 2130-2144 15 p.

Research output: Contribution to journalArticle

50 Scopus citations
2005

Chemokines as attractive targets in liver carcinogenesis [4]

Roberts, L. R., Feb 2005, In : American Journal of Gastroenterology. 100, 2, p. 499-501 3 p.

Research output: Contribution to journalLetter

7 Scopus citations

Hepatocellular carcinoma: Molecular pathways and new therapeutic targets

Roberts, L. R. & Gores, G. J., May 1 2005, In : Seminars in Liver Disease. 25, 2, p. 212-225 14 p.

Research output: Contribution to journalReview article

236 Scopus citations

The role of hepatitis B virus integrations in the pathogenesis of human hepatocellular carcinoma

Guerrero, R. B. & Roberts, L. R., May 2005, In : Journal of hepatology. 42, 5, p. 760-777 18 p.

Research output: Contribution to journalReview article

133 Scopus citations
2004

A comparison of routine cytology and fluorescence in situ hybridization for the detection of malignant bile duct strictures

Kipp, B. R., Stadheim, L. M., Halling, S. A., Pochron, N. L., Harmsen, S., Nagorney, D. M., Sebo, T. J., Therneau, T. M., Gores, G. J., De Groen, P. C., Baron, T. H., Levy, M. J., Halling, K. C. & Roberts, L. R., Sep 1 2004, In : American Journal of Gastroenterology. 99, 9, p. 1675-1681 7 p.

Research output: Contribution to journalArticle

264 Scopus citations

Erratum: Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer (Journal of Biological Chemistry (2003) 278 (23107-23117))

Lai, J., Chien, J., Staub, J., Avula, R., Greene, L. E., Matthews, T. A., Smith, D. I., Kaufmann, S. H., Roberts, L. R. & Shridhar, V., Mar 26 2004, In : Journal of Biological Chemistry. 279, 13, 1 p.

Research output: Contribution to journalComment/debate

HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma

Lai, J. P., Chien, J., Strome, S. E., Staub, J., Montoya, D. P., Greene, E. L., Smith, D. I., Roberts, L. R. & Shridhar, V., Feb 19 2004, In : Oncogene. 23, 7, p. 1439-1447 9 p.

Research output: Contribution to journalArticle

107 Scopus citations

hSulf1 Sulfatase Promotes Apoptosis of Hepatocellular Cancer Cells by Decreasing Heparin-Binding Growth Factor Signaling

Lai, J. P., Chien, J. R., Moser, D. R., Staub, J. K., Aderca, I., Montoya, D. P., Matthews, T. A., Nagorney, D. M., Cunningham, J. M., Smith, D. I., Greene, E. L., Shridhar, V. & Roberts, L. R., Jan 2004, In : Gastroenterology. 126, 1 SUPPL. 1, p. 231-248 18 p.

Research output: Contribution to journalArticle

120 Scopus citations

Parkin Gene Alterations in Hepatocellular Carcinoma

Wang, F., Denison, S., Lai, J. P., Philips, L. A., Montoya, D., Kock, N., Schüle, B., Klein, C., Shridhar, V., Roberts, L. R. & Smith, D. I., Jun 2004, In : Genes Chromosomes and Cancer. 40, 2, p. 85-96 12 p.

Research output: Contribution to journalArticle

89 Scopus citations
2003

67-Year-old man with hepatitis C infection and abdominal distention

Choong, N. W. W., Asfandiyar, S. & Roberts, L. R., Feb 1 2003, In : Mayo Clinic proceedings. 78, 2, p. 217-220 4 p.

Research output: Contribution to journalArticle

Open Access

Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers

Ferber, M. J., Montoya, D. P., Yu, C., Aderca, I., McGee, A., Thorland, E. C., Nagorney, D. M., Gostout, B. S., Burgart, L. J., Boix, L., Bruix, J., McMahon, B. J., Cheung, T. H., Chung, T. K. H., Wong, Y. F., Smith, D. I. & Roberts, L. R., Jun 12 2003, In : Oncogene. 22, 24, p. 3813-3820 8 p.

Research output: Contribution to journalArticle

155 Scopus citations

Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer

Lai, J., Chien, J., Staub, J., Avula, R., Greene, E. L., Matthews, T. A., Smith, D. I., Kaufmann, S. H., Roberts, L. R. & Shridhar, V., Jun 20 2003, In : Journal of Biological Chemistry. 278, 25, p. 23107-23117 11 p.

Research output: Contribution to journalArticle

193 Scopus citations

Primer on medical genomics part VI: Genomics and molecular genetics in clinical practice

Ansell, S. M., Ackerman, M. J., Black, J. L., Roberts, L. R. & Tefferi, A., Mar 1 2003, In : Mayo Clinic proceedings. 78, 3, p. 307-317 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Tumor seeding complicating radiofrequency ablation of hepatocellular carcinoma

Decker, G. A., Gores, G. J. & Roberts, L. R., May 1 2003, In : Journal of hepatology. 38, 5, 1 p.

Research output: Contribution to journalArticle

6 Scopus citations
2002

Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

Taniguchi, K., Roberts, L. R., Aderca, I. N., Dong, X., Qian, C., Murphy, L. M., Nagorney, D. M., Burgart, L. J., Roche, P. C., Smith, D. I., Ross, J. A. & Liu, W., Jan 1 2002, In : Oncogene. 21, 31, p. 4863-4871 9 p.

Research output: Contribution to journalArticle

374 Scopus citations
2001

hMLH1 and hMSH2 expression in human hepatocellular carcinoma.

Wang, L., Bani-Hani, A., Montoya, D. P., Roche, P. C., Thibodeau, S. N., Burgart, L. J. & Roberts, L. R., Sep 2001, In : International journal of oncology. 19, 3, p. 567-570 4 p.

Research output: Contribution to journalArticle

38 Scopus citations
2000
12 Scopus citations

The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations

Krummel, K. A., Roberts, L. R., Kawakami, M., Glover, T. W. & Smith, D. I., Oct 1 2000, In : Genomics. 69, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

82 Scopus citations
1999

Cathepsins as effector proteases in hepatocyte apoptosis

Roberts, L. R., Adjei, P. N. & Gores, G. J., Jan 1 1999, In : Cell Biochemistry and Biophysics. 30, 1, p. 71-88 18 p.

Research output: Contribution to journalArticle

92 Scopus citations

Pathophysiology of variceal bleeding

Roberts, L. R. & Kamath, P. S., 1999, In : Gastrointestinal Endoscopy Clinics of North America. 9, 2, p. 167-174 8 p.

Research output: Contribution to journalReview article

11 Scopus citations
1998

Dysregulation of apoptosis as a mechanism of liver disease: An overview

Patel, T., Roberts, L. R., Jones, B. A. & Gores, G. J., Jan 1 1998, In : Seminars in liver disease. 18, 2, p. 105-114 10 p.

Research output: Contribution to journalArticle

141 Scopus citations

Image of the month

Roberts, L. R., Burgart, L. J. & Patel, T., Jan 1 1998, In : Gastroenterology. 114, 3, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Image of the month. Solitary rectal ulcer.

Roberts, L. R., Burgart, L. J. & Patel, T., Mar 1998, In : Gastroenterology. 114, 3

Research output: Contribution to journalArticle

Prophylaxis and pharmacotherapy of variceal hemorrhage

Roberts, L. R. & Kamath, P. S., Dec 1 1998, In : Problems in General Surgery. 15, 4, p. 52-62 11 p.

Research output: Contribution to journalReview article

1997

Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes

Roberts, L. R., Kurosawa, H., Bronk, S. F., Fesmier, P. J., Agellon, L. B., Leung, Y., Mao, F. & Gores, G. J., Jan 1 1997, In : Gastroenterology. 113, 5, p. 1714-1726 13 p.

Research output: Contribution to journalArticle

154 Scopus citations

Hepatocytes in the bile duct-ligated rat express Bcl-2

Kurosawa, H., Que, F. G., Roberts, L. R., Fesmier, P. J. & Gores, G. J., Jun 1997, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 272, 6 35-6, p. G1587-G1593

Research output: Contribution to journalArticle

84 Scopus citations

Serum-ascitic fluid albumin gradient, portal hypertension, and ascites

Rubin, E., Roberts, L. R. & Kamath, P. S., Jan 1 1997, In : Mayo Clinic proceedings. 72, 5, 1 p.

Research output: Contribution to journalLetter

Open Access
2 Scopus citations

The role of hepatocyte apoptosis in liver diseases and growth regulation

Roberts, L. R. & Gores, G. J., Dec 1 1997, In : Progress in liver diseases. 15, p. 57-83 27 p.

Research output: Contribution to journalArticle

3 Scopus citations
1996

Ascites and hepatorenal syndrome: Pathophysiology and management

Roberts, L. R. & Kamath, P. S., Jan 1 1996, In : Mayo Clinic proceedings. 71, 9, p. 874-881 8 p.

Research output: Contribution to journalReview article

32 Scopus citations

MELAS- and Kearns-Sayre-type commutation with myopathy and autoimmune polyendocrinopathy

Ohno, K., Yamamoto, M., Engel, A. G., Harper, C. M., Roberts, L. R., Tan, G. H. & Fatourechi, V., Jun 1 1996, In : Annals of neurology. 39, 6, p. 761-766 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Pathophysiology and treatment of variceal hemorrhage

Roberts, L. R. & Kamath, P. S., Jan 1 1996, In : Mayo Clinic proceedings. 71, 10, p. 973-983 11 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations
1995

cDNA and amino-acid sequences and organization of the gene encoding the Bβ subunit of fibrinogen from Xenopus laevis

Roberts, L. R., Nichols, L. A. & Holland, L., 1995, In : Gene. 160, 2, p. 223-228 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
1993
12 Scopus citations
12 Scopus citations
1992

A major estrogen-regulated protein secreted from the liver of xenopus Laevis is a member of the serpin superfamily: Nucleotide sequence of cDNA and hormonal Induction of mRNA

Holland, L. J., Suksang, C., Wall, A. A., Roberts, L. R., Moser, D. R. & Bhattacharya, A., Apr 5 1992, In : Journal of Biological Chemistry. 267, 10, p. 7053-7059 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
1991

Molecular cloning of cDNA for the Bβ subunit of Xenopus fibrinogen, the product of a coordinately-regulated gene family

Bhattacharya, A., Shepard, A. R., Moser, D. R., Roberts, L. R. & Holland, L., 1991, In : Molecular and Cellular Endocrinology. 75, 2, p. 111-121 11 p.

Research output: Contribution to journalArticle

7 Scopus citations