Lewis Rowland Roberts, MB, ChB, PhD

  • 19948 Citations
  • 78 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2011

Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: Associated signaling pathways, tumor phenotypes, and survival

Yang, J. D., Sun, Z., Hu, C., Lai, J., Dove, R., Nakamura, I., Lee, J. S., Thorgeirsson, S. S., Kang, K. J., Chu, I. S. & Roberts, L. R., Feb 2011, In : Genes Chromosomes and Cancer. 50, 2, p. 122-135 14 p.

Research output: Contribution to journalArticle

37 Scopus citations

Telomerase mutation: A genetic risk factor for cirrhosis

Chaiteerakij, R. & Roberts, L. R., May 1 2011, In : Hepatology. 53, 5, p. 1430-1432 3 p.

Research output: Contribution to journalComment/debate

14 Scopus citations

The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets

Yang, J. D., Nakamura, I. & Roberts, L. R., Feb 1 2011, In : Seminars in Cancer Biology. 21, 1, p. 35-43 9 p.

Research output: Contribution to journalReview article

241 Scopus citations

Utility of serum immunoglobulin G4 in distinguishing immunoglobulin G4-associated cholangitis from cholangiocarcinoma

Oseini, A. M., Chaiteerakij, R., Shire, A. M., Ghazale, A., Kaiya, J., Moser, C. D., Aderca, I., Mettler, T. A., Therneau, T. M., Zhang, L., Takahashi, N., Chari, S. T. & Roberts, L. R., Sep 2 2011, In : Hepatology. 54, 3, p. 940-948 9 p.

Research output: Contribution to journalArticle

125 Scopus citations
2010

A necrotic liver mass

Sweetser, S., Roberts, L. R. & Medeiros, F., Sep 2010, In : Gastroenterology. 139, 3, p. e6-e7

Research output: Contribution to journalArticle

Comparison of KRAS mutation analysis and FISH for detecting pancreatobiliary tract cancer in cytology specimens collected during endoscopic retrograde cholangiopancreatography

Kipp, B. R., Barr Fritcher, E. G., Clayton, A. C., Gores, G. J., Roberts, L. R., Zhang, J., Levy, M. J. & Halling, K. C., Nov 1 2010, In : Journal of Molecular Diagnostics. 12, 6, p. 780-786 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

Epidemiology and Management of Hepatocellular Carcinoma

Yang, J. D. & Roberts, L. R., Dec 1 2010, In : Infectious Disease Clinics of North America. 24, 4, p. 899-919 21 p.

Research output: Contribution to journalReview article

116 Scopus citations

Evaluation of a focal lesion in the liver

Tharayil, V. & Roberts, L. R., 2010, In : Gastroenterology. 139, 2, p. e10-e11

Research output: Contribution to journalArticle

4 Scopus citations

GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis

Kurita, S., Mott, J. L., Almada, L. L., Bronk, S. F., Werneburg, N. W., Sun, S. Y., Roberts, L. R., Fernandez-Zapico, M. E. & Gores, G. J., Aug 26 2010, In : Oncogene. 29, 34, p. 4848-4858 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Hepatic adenomas associated with antiepileptic drugs: A case series and imaging review

Lee, P. U. Y., Roberts, L. R., Kaiya, J. K. & Lee, C. U., Apr 1 2010, In : Abdominal Imaging. 35, 2, p. 208-211 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Hepatocellular carcinoma: A global view

Yang, J. D. & Roberts, L. R., Aug 1 2010, In : Nature Reviews Gastroenterology and Hepatology. 7, 8, p. 448-458 11 p.

Research output: Contribution to journalReview article

846 Scopus citations

Hepatocellular Carcinoma

Roberts, L. R., Aug 31 2010, Practical Gastroenterology and Hepatology: Liver and Biliary Disease. Wiley-Blackwell, p. 144-151 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines

Henry, J. C., Park, J. K., Jiang, J., Kim, J. H., Nagorney, D. M., Roberts, L. R., Banerjee, S. & Schmittgen, T. D., Dec 3 2010, In : Biochemical and Biophysical Research Communications. 403, 1, p. 120-125 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

Sulfatase 2 protects hepatocellular carcinoma cells against apoptosis induced by the PI3K inhibitor LY294002 and ERK and JNK kinase inhibitors

Lai, J. P., Sandhu, D. S., Yu, C., Moser, C. D., Hu, C., Shire, A. M., Aderca, I., Murphy, L. M., Adjei, A. A., Sanderson, S. & Roberts, L. R., Nov 2010, In : Liver International. 30, 10, p. 1522-1528 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

The development and validation of a nocturnal gastro-oesophageal reflux disease symptom severity and impact questionnaire for adults

Spiegel, B. M., Roberts, L., Mody, R., Harding, G., Kothari-Talwar, S., Kahrilas, P. J., Camilleri, M. L., Dabbous, O. & Revicki, D. A., Aug 1 2010, In : Alimentary Pharmacology and Therapeutics. 32, 4, p. 591-602 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3-dependent Wnt activation

Lai, J. P., Oseini, A. M., Moser, C. D., Yu, C., Elsawa, S. F., Hu, C., Nakamura, I., Han, T., Aderca, I., Isomoto, H., Garrity-Park, M. M., Shire, A. M., Li, J., Sanderson, S. O., Adjei, A. A., Fernandez-Zapico, M. E. & Roberts, L. R., Nov 2010, In : Hepatology. 52, 5, p. 1680-1689 10 p.

Research output: Contribution to journalArticle

70 Scopus citations

Utility of serum YKL-40 as a tumor-specific marker of hepatobiliary malignancies

Yang, J. D., Kim, E., Pedersen, R. A., Kim, W. R., Pungpapong, S. & Roberts, L. R., Dec 1 2010, In : Gut and Liver. 4, 4, p. 537-542 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
2009

Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo

Lai, J. P., Sandhu, D. S., Moser, C. D., Cazanave, S. C., Oseini, A. M., Shire, A. M., Shridhar, V., Sanderson, S. O. & Roberts, L. R., Jun 2009, In : Journal of hepatology. 50, 6, p. 1112-1121 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

A Multivariable Model Using Advanced Cytologic Methods for the Evaluation of Indeterminate Pancreatobiliary Strictures

Barr Fritcher, E. G., Kipp, B. R., Halling, K. C., Oberg, T. N., Bryant, S. C., Tarrell, R. F., Gores, G. J., Levy, M. J., Clayton, A. C., Sebo, T. J. & Roberts, L. R., Jun 2009, In : Gastroenterology. 136, 7, p. 2180-2186 7 p.

Research output: Contribution to journalArticle

116 Scopus citations

A new, effective and high-yield approach for identifying liver tumor suppressors

Olgun, E. & Roberts, L. R., Feb 26 2009, In : Genome medicine. 1, 2, gm26.

Research output: Contribution to journalShort survey

1 Scopus citations

Hepatic Vein Tumor Thrombus as a Risk Factor for Excessive Pulmonary Deposition of Microspheres during TheraSphere Therapy for Unresectable Hepatocellular Carcinoma

Fleming, C. J., Andrews, J. C., Wiseman, G. A., Gansen, D. N. & Roberts, L. R., Nov 1 2009, In : Journal of Vascular and Interventional Radiology. 20, 11, p. 1460-1463 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Hepatocellular cancer

Whittle, D. O. & Roberts, L., Jun 1 2009, In : West Indian Medical Journal. 58, 3, p. 273-276 4 p.

Research output: Contribution to journalReview article

Hepatocellular Carcinoma

Roberts, L. R. & Gores, G. J., Feb 17 2009, Textbook of Gastroenterology, Fifth Edition. Blackwell Publishing Ltd, Vol. 2. p. 2386-2411 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Liver transplantation after radioembolization in a patient with unresectable HCC

Luna, L. E. M., Kwo, P. Y., Roberts, L. R., Mettler, T. A., Gansen, D. N., Andrews, J. C., Wiseman, G. A. & Misra, V. L., Nov 16 2009, In : Nature Reviews Gastroenterology and Hepatology. 6, 11, p. 679-683 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

New data on hepatocellular carcinoma

Schoenleber, S. J., Kurtz, D. M., Talwalkar, J. A., Roberts, L. R. & Gores, G. J., Feb 1 2009, In : Gastroenterology and Hepatology. 5, 2 SUPPL. 8, 1 p.

Research output: Contribution to journalArticle

PDGFRα: A new therapeutic target in the treatment of hepatocellular carcinoma?

Oseini, A. M. & Roberts, L. R., Apr 1 2009, In : Expert opinion on therapeutic targets. 13, 4, p. 443-454 12 p.

Research output: Contribution to journalReview article

35 Scopus citations

Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: Systematic review and meta-analysis

Schoenleber, S. J., Kurtz, D. M., Talwalkar, J. A., Roberts, L. R. & Gores, G. J., May 5 2009, In : British journal of cancer. 100, 9, p. 1385-1392 8 p.

Research output: Contribution to journalArticle

166 Scopus citations

α-Fetoprotein, Des-γ Carboxyprothrombin, and Lectin-Bound α-Fetoprotein in Early Hepatocellular Carcinoma

Marrero, J. A., Feng, Z., Wang, Y., Nguyen, M. H., Befeler, A. S., Roberts, L. R., Reddy, K. R., Harnois, D., Llovet, J. M., Normolle, D., Dalhgren, J., Chia, D., Lok, A. S., Wagner, P. D., Srivastava, S. & Schwartz, M., Jul 2009, In : Gastroenterology. 137, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

369 Scopus citations
2008

A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation

Chien, J., Narita, K., Rattan, R., Giri, S., Shridhar, R., Staub, J., Beleford, D., Lai, J., Roberts, L. R., Molina, J., Kaufmann, S. H., Prendergast, G. C. & Shridhar, V., Dec 11 2008, In : Oncogene. 27, 58, p. 7223-7234 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Association of microRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival

Jiang, J., Gusev, Y., Aderca, I., Mettler, T. A., Nagorney, D. M., Brackett, D. J., Roberts, L. R. & Schmittgen, T. D., Jan 15 2008, In : Clinical Cancer Research. 14, 2, p. 419-427 9 p.

Research output: Contribution to journalArticle

443 Scopus citations

Clinical Challenges and Images in GI

Veerasamy, M., Roberts, L. R. & Andrews, J. C., Jul 2008, In : Gastroenterology. 135, 1, p. 18,328

Research output: Contribution to journalComment/debate

Diagnosis and management of cholangiocarcinoma

Sandhu, D. S. & Roberts, L. R., Dec 1 2008, In : Current gastroenterology reports. 10, 1, p. 43-52 10 p.

Research output: Contribution to journalReview article

20 Scopus citations

Epigenetic DNA hypermethylation in cholangiocarcinoma: Potential roles in pathogenesis, diagnosis and identification of treatment targets

Sandhu, D. S., Shire, A. M. & Roberts, L. R., Jan 1 2008, In : Liver International. 28, 1, p. 12-27 16 p.

Research output: Contribution to journalReview article

36 Scopus citations

Heparin-degrading sulfatases in hepatocellular carcinoma: Roles in pathogenesis and therapy targets

Lai, J. P., Thompson, J. R., Sandhu, D. S. & Roberts, L. R., 2008, In : Future Oncology. 4, 6, p. 803-814 12 p.

Research output: Contribution to journalReview article

34 Scopus citations

Prospective evaluation of advanced molecular markers and imaging techniques in patients with indeterminate bile duct strictures

Levy, M. J., Baron, T. H., Clayton, A. C., Enders, F. B., Gostout, C. J., Halling, K. C., Kipp, B. R., Petersen, B. T., Roberts, L. R., Rumalla, A., Sebo, T. J., Topazian, M. D., Wiersema, M. J. & Gores, G. J., May 1 2008, In : American Journal of Gastroenterology. 103, 5, p. 1263-1273 11 p.

Research output: Contribution to journalArticle

130 Scopus citations

Sorafenib in liver cancer - Just the beginning

Roberts, L. R., Jul 24 2008, In : New England Journal of Medicine. 359, 4, p. 420-422 3 p.

Research output: Contribution to journalEditorial

82 Scopus citations

Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma

Lai, J. P., Sandhu, D. S., Yu, C., Han, T., Moser, C. D., Jackson, K. K., Guerrero, R. B., Aderca, I., Isomoto, H., Garrity-Park, M. M., Zou, H., Shire, A. M., Nagorney, D. M., Sanderson, S. O., Adjei, A. A., Lee, J. S., Thorgeirsson, S. S. & Roberts, L. R., Apr 2008, In : Hepatology. 47, 4, p. 1211-1222 12 p.

Research output: Contribution to journalArticle

142 Scopus citations

The editorialist replies

Roberts, L. R., Dec 4 2008, In : New England Journal of Medicine. 359, 23, 1 p.

Research output: Contribution to journalLetter

The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX

Aderca, I., Moser, C. D., Veerasamy, M., Bani-Hani, A. H., Bonilla-Guerrero, R., Ahmed, K., Shire, A., Cazanave, S. C., Montoya, D. P., Mettler, T. A., Burgart, L. J., Nagorney, D. M., Thibodeau, S. N., Cunningham, J. M., Lai, J. P. & Roberts, L. R., Sep 2008, In : Journal of hepatology. 49, 3, p. 373-383 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

The tumor suppressor function of human sulfatase 1 (SULF1) in carcinogenesis

Lai, J. P., Sandhu, D. S., Shire, A. M. & Roberts, L. R., Mar 2008, In : Journal of gastrointestinal cancer. 39, 1-4, p. 149-158 10 p.

Research output: Contribution to journalReview article

56 Scopus citations

Treatment options for hepatocellular carcinoma

Sandhu, D. S., Tharayil, V. S., Lai, J. P. & Roberts, L. R., Feb 2008, In : Expert Review of Gastroenterology and Hepatology. 2, 1, p. 81-92 12 p.

Research output: Contribution to journalReview article

29 Scopus citations
2007

{A figure is presented}The Utility of Lens Culinaris Agglutinin-Reactive α-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma: Evaluation in a United States Referral Population

Leerapun, A., Suravarapu, S. V., Bida, J. P., Clark, R. J., Sanders, E. L., Mettler, T. A., Stadheim, L. M., Aderca, I., Moser, C. D., Nagorney, D. M., LaRusso, N. F., de Groen, P. C., Menon, K. V. N., Lazaridis, K. N., Gores, G. J., Charlton, M. R., Roberts, R. O., Therneau, T. M., Katzmann, J. A. & Roberts, L. R., Mar 1 2007, In : Clinical Gastroenterology and Hepatology. 5, 3, p. 394-402 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Abrogation of MAPK and Akt signaling by AEE788 synergistically potentiates histone deacetylase inhibitor-induced apoptosis through reactive oxygen species generation

Yu, C., Friday, B. B., Lai, J. P., McCollum, A., Atadja, P., Roberts, L. R. & Adjei, A. A., Feb 15 2007, In : Clinical Cancer Research. 13, 4, p. 1140-1148 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

A Moveable Feast

Camilleri, M., Sandborn, W. J., Kolars, J. C., Murray, J. A., Poterucha, J. J., Roberts, L., Sinicrope, F. A. & Wang, K. K., Jun 1 2007, In : Clinical Gastroenterology and Hepatology. 5, 6, p. 646-647 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

An assessment of chromosomal alterations detected by fluorescence in situ hybridization and p16 expression in sporadic and primary sclerosing cholangitis-associated cholangiocarcinomas

DeHaan, R. D., Kipp, B. R., Smyrk, T. C., Abraham, S. C., Roberts, L. R. & Halling, K. C., Mar 1 2007, In : Human Pathology. 38, 3, p. 491-499 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Casting a wider net: Improving access to medical literature in developing countries

Roberts, L. R., Missen, C. & Grimes, G. C., Jul 2007, In : Mayo Clinic proceedings. 82, 7, p. 846-848 3 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Correlating routine cytology, quantitative nuclear morphometry by digital image analysis, and genetic alterations by fluorescence in situ hybridization to assess the sensitivity of cytology for detecting pancreatobiliary tract malignancy

Barr Fritcher, E. G., Kipp, B. R., Slezak, J. M., Moreno-Luna, L. E., Gores, G. J., Levy, M. J., Roberts, L. R., Halling, K. C. & Sebo, T. J., Aug 1 2007, In : American journal of clinical pathology. 128, 2, p. 272-279 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Epigenetic silencing of HSulf-1 in ovarian cancer: Implications in chemoresistance

Staub, J., Chien, J., Pan, Y., Qian, X., Narita, K., Aletti, G., Scheerer, M., Roberts, L. R., Molina, J. & Shridhar, V., Jul 26 2007, In : Oncogene. 26, 34, p. 4969-4978 10 p.

Research output: Contribution to journalArticle

79 Scopus citations

Factors Associated With Increased Survival After Photodynamic Therapy for Cholangiocarcinoma

Prasad, G. A., Wang, K. K., Baron, T. H., Buttar, N. S., Wongkeesong, L. M., Roberts, L. R., LeRoy, A. J., Lutzke, L. S. & Borkenhagen, L. S., Jun 1 2007, In : Clinical Gastroenterology and Hepatology. 5, 6, p. 743-748 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Hypothyroidism: A Possible Risk Factor for Liver Cancer in Patients With No Known Underlying Cause of Liver Disease

Reddy, A., Dash, C., Leerapun, A., Mettler, T. A., Stadheim, L. M., Lazaridis, K. N., Roberts, R. O. & Roberts, L. R., Jan 1 2007, In : Clinical Gastroenterology and Hepatology. 5, 1, p. 118-123 6 p.

Research output: Contribution to journalArticle

54 Scopus citations