Konstantinos N Lazaridis, MD, FACP, AGAF

  • 5570 Citations
  • 38 Scopus h-Index
1993 …2019

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2019

Clinical Applications and Utility of a Precision Medicine Approach for Patients With Unexplained Cytopenias

Mangaonkar, A. A., Ferrer, A., Pinto e Vairo, F., Cousin, M. A., Kuisle, R. J., Gangat, N., Hogan, W. J., Litzow, M. R., McAllister, T. M., Klee, E. W., Lazaridis, K. N., Stewart, A. K. & Patnaik, M. M., Jan 1 2019, In : Mayo Clinic proceedings.

Research output: Contribution to journalArticle

1 Scopus citations
7 Scopus citations

Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning

Eaton, J. E., Vesterhus, M., McCauley, B. M., Atkinson, E. J., Schlicht, E. M., Juran, B. D., Gossard, A. A., La Russo, N. F., Gores, G. J., Karlsen, T. H. & Lazaridis, K. N., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

8 Scopus citations
2018

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis

Müller, T., Alberts, R., De Vries, E. M. G., Goode, E. C., Jiang, X., Sampaziotis, F., Rombouts, K., Böttcher, K., Folseraas, T., Weismüller, T. J., Mason, A. L., Wang, W., Alexander, G., Alvaro, D., Bergquist, A., Björkström, N. K., Beuers, U., Björnsson, E., Boberg, K. M., Bowlus, C. L. & 54 others, Bragazzi, M. C., Carbone, M., Chazouillères, O., Cheung, A., Dalekos, G., Eaton, J., Eksteen, B., Ellinghaus, D., Färkkilä, M., Festen, E. A. M., Floreani, A., Franceschet, I., Gotthardt, D. N., Hirschfield, G. M., Hoek, B. V., Holm, K., Hohenester, S., Hov, J. R., Imhann, F., Invernizzi, P., Juran, B. D., Lenzen, H., Lieb, W., Liu, J. Z., Marschall, H. U., Marzioni, M., Melum, E., Milkiewicz, P., Pares, A., Rupp, C., Rust, C., Sandford, R. N., Schramm, C., Schreiber, S., Schrumpf, E., Silverberg, M. S., Srivastava, B., Sterneck, M., Teufel, A., Vallier, L., Verheij, J., Vila, A. V., De Vries, B., Zachou, K., Chapman, R. W., Manns, M. P., Pinzani, M., Rushbrook, S. M., Lazaridis, K. N., Franke, A., Anderson, C. A., Karlsen, T. H., Ponsioen, C. Y. & Weersma, R. K., Aug 1 2018, In : Gut. 67, 8, p. 1517-1524 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Metabolomic profiling of portal blood and bile reveals metabolic signatures of primary sclerosing cholangitis

Tietz-Bogert, P. S., Kim, M., Cheung, A., Tabibian, J. H., Heimbach, J. K., Rosen, C. B., Nandakumar, M., Lazaridis, K. N., La Russo, N. F., Sung, J. & O’hara, S. P., Oct 16 2018, In : International Journal of Molecular Sciences. 19, 10, 3188.

Research output: Contribution to journalArticle

4 Scopus citations
1 Scopus citations

PNPLA3 association with alcoholic liver disease in a cohort of heavy drinkers

Kolla, B. P., Schneekloth, T. D., Biernacka, J. M., Shah, V., Lazaridis, K. N., Geske, J. & Karpyak, V. M., Jan 1 2018, In : Alcohol and Alcoholism. 53, 4, p. 357-360 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Primary biliary cholangitis, DNA, and beyond: The Relative contribution of genes

Gulamhusein, A. F. & Lazaridis, K. N., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Doublecortin domain containing protein 2 (DCDC2) genetic variants in primary sclerosing cholangitis

Cheung, A. C., Juran, B. D., Moore, R. M., La Russo, N. F. & Lazaridis, K. N., 2017, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

1 Scopus citations

Emerging pharmacologic therapies for primary sclerosing cholangitis

Cheung, A. C., Lazaridis, K. N., La Russo, N. F. & Gores, G. J., Mar 2 2017, (Accepted/In press) In : Current Opinion in Gastroenterology.

Research output: Contribution to journalArticle

4 Scopus citations

Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis

Cheung, A. C., La Russo, N. F., Gores, G. J. & Lazaridis, K. N., May 1 2017, In : Seminars in Liver Disease. 37, 2, p. 159-174 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Experience with precision genomics and tumor board, indicates frequent target identification, but barriers to delivery

Bryce, A. H., Egan, J. B., Borad, M. J., Stewart, A. K., Nowakowski, G. S., Chanan Khan, A. A., Patnaik, M. M., Ansell, S. M., Banck, M. S., Robinson, S., Mansfield, A., Klee, E. W., Oliver, G. R., McCormick, J. B., Huneke, N. E., Tagtow, C. M., Jenkins, R. B., Rumilla, K. M., Kerr, S. E., Kocher, J-P. & 5 others, Beck, S. A., Fernandez-Zapico, M. E., Farrugia, G., Lazaridis, K. N. & Mc Williams, R. R., 2017, In : Oncotarget. 8, 16, p. 27145-27154 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry

The UK-PSC Consortium, Oct 1 2017, In : HLA. 90, 4, p. 228-233 6 p.

Research output: Contribution to journalArticle

Improving Therapeutic Odyssey: Preemptive Pharmacogenomics Utility in Patient Care

Lazaridis, K. N., Jan 1 2017, In : Clinical Pharmacology and Therapeutics. 101, 1, p. 39-41 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis

on behalf of the & International PSC Study Group, Jun 1 2017, In : Gastroenterology. 152, 8, p. 1975-1984.e8

Research output: Contribution to journalArticle

111 Scopus citations

Pharmacogenomic findings from clinical whole exome sequencing of diagnostic odyssey patients

Cousin, M. A., Matey, E. T., Blackburn, P. R., Boczek, N. J., McAllister, T. M., Kruisselbrink, T. M., Babovic-Vuksanovic, D., Lazaridis, K. N. & Klee, E. W., Jan 1 2017, In : Molecular Genetics and Genomic Medicine. 5, 3, p. 269-279 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
3 Scopus citations

The prevalence of diseases caused by lysosome-related genes in a cohort of undiagnosed patients

Vairo, F. P., Boczek, N. J., Cousin, M. A., Kaiwar, C., Blackburn, P. R., Conboy, E., Lanpher, B., Gavrilova, R. M., Pichurin, P. N., Lazaridis, K. N., Babovic-Vuksanovic, D. & Klee, E. W., Dec 1 2017, In : Molecular Genetics and Metabolism Reports. 13, p. 46-51 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Variations in primary sclerosing cholangitis across the age spectrum

Eaton, J. E., McCauley, B. M., Atkinson, E. J., Juran, B. D., Schlicht, E. M., De Andrade, M. & Lazaridis, K. N., Oct 1 2017, In : Journal of Gastroenterology and Hepatology (Australia). 32, 10, p. 1763-1768 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

Ellinghaus, D., Jostins, L., Spain, S. L., Cortes, A., Bethune, J., Han, B., Park, Y. R., Raychaudhuri, S., Pouget, J. G., Hübenthal, M., Folseraas, T., Wang, Y., Esko, T., Metspalu, A., Westra, H. J., Franke, L., Pers, T. H., Weersma, R. K., Collij, V., D'Amato, M. & 25 others, Halfvarson, J., Jensen, A. B., Lieb, W., Degenhardt, F., Forstner, A. J., Hofmann, A., Schreiber, S., Mrowietz, U., Juran, B. D., Lazaridis, K. N., Brunak, SØ., Dale, A. M., Trembath, R. C., Weidinger, S., Weichenthal, M., Ellinghaus, E., Elder, J. T., Barker, J. N. W. N., Andreassen, O. A., McGovern, D. P., Karlsen, T. H., Barrett, J. C., Parkes, M., Brown, M. A. & Franke, A., May 1 2016, In : Nature Genetics. 48, 5, p. 510-518 9 p.

Research output: Contribution to journalArticle

189 Scopus citations

Clinical characteristics and platelet phenotype in a family with RUNX1 mutated thrombocytopenia

Perez Botero, J., Chen, D., Cousin, M. A., Majerus, J. A., Coon, L. M., Kruisselbrink, T. M., Klee, E. W., Lazaridis, K. N., Pruthi, R. K. & Patnaik, M. M., Dec 8 2016, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-5 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Clinical Implementation of Integrated Genomic Profiling in Patients with Advanced Cancers

Borad, M. J., Egan, J. B., Condjella, R. M., Liang, W. S., Fonseca, R., Ritacca, N. R., McCullough, A. E., Barrett, M., Hunt, K. S., Champion, M. D., Patel, M. D., Young, S. W., Silva, A. C., Ho, T. H., Halfdanarson, T. R., Mc Williams, R. R., Lazaridis, K. N., Ramanathan, R. K., Baker, A., Aldrich, J. & 17 others, Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Cuyugan, L., McDonald, J., Adkins, J., Mastrian, S. D., Valdez, R., Jaroszewski, D. E., Von Hoff, D. D., Craig, D. W., Stewart, A. K., Carpten, J. D. & Bryce, A. H., 2016, In : Scientific Reports. 6, 1, 25.

Research output: Contribution to journalArticle

11 Scopus citations

Duration of inflammatory bowel disease is associated with increased risk of cholangiocarcinoma in patients with primary sclerosing cholangitis and IBD

Gulamhusein, A. F., Eaton, J. E., Tabibian, J. H., Atkinson, E. J., Juran, B. D. & Lazaridis, K. N., May 1 2016, In : American Journal of Gastroenterology. 111, 5, p. 705-711 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

The UK-PSC Consortium, The International IBD Genetics Consortium & The International PSC Study Group, Dec 19 2016, (Accepted/In press) In : Nature Genetics.

Research output: Contribution to journalArticle

53 Scopus citations

Low incidence of primary biliary cirrhosis (PBC) in the first-degree relatives of PBC probands after 8 years of follow-up

Gulamhusein, A. F., Juran, B. D., Atkinson, E. J., Mccauley, B., Schlicht, E. & Lazaridis, K. N., 2016, (Accepted/In press) In : Liver International.

Research output: Contribution to journalArticle

10 Scopus citations

Molecular cytology genotyping of primary and metastatic GI stromal tumors by using a custom two-gene targeted next-generation sequencing panel with therapeutic intent

Gleeson, F. C., Kerr, S. E., Kipp, B. R., Voss, J. S., Minot, D. M., Tu, Z. J., Henry, M. R., Vasmatzis, G., Cheville, J. C., Lazaridis, K. N. & Levy, M. J., Jan 24 2016, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

3 Scopus citations

Outcome of Whole Exome Sequencing for Diagnostic Odyssey Cases of an Individualized Medicine Clinic: The Mayo Clinic Experience

Lazaridis, K. N., Schahl, K. A., Cousin, M. A., Babovic-Vuksanovic, D., Riegert-Johnson, D. L., Gavrilova, R. M., McAllister, T. M., Lindor, N. M., Abraham, R. S., Ackerman, M. J., Pichurin, P. N., Deyle, D. R., Gavrilov, D. K., Hand, J. L., Klee, E. W., Stephens, M. C., Wick, M. J., Atkinson, E. J., Linden, D. R., Ferber, M. J. & 19 others, Wieben, E. D., Farrugia, G., Baudhuin, L. M., Beck, S. A., Beek, G. J., Go, R. S., Guthrie, K. J., Hovan, M. J., Hunt, K. S., Kemppainen, J. L., Kruisselbrink, T. M., McCormick, J. B., McLaughlin, B. M., Murphree, M. I., Niewold, T. B., Oglesbee, D., Reed, A., Thibodeau, S. N. & Thorland, E. C., Mar 1 2016, In : Mayo Clinic Proceedings. 91, 3, p. 297-307 11 p.

Research output: Contribution to journalArticle

56 Scopus citations

Performance of magnetic resonance elastography in primary sclerosing cholangitis

Eaton, J. E., Dzyubak, B., Venkatesh, S. K., Smyrk, T. C., Gores, G. J., Ehman, R. L., La Russo, N. F., Gossard, A. A. & Lazaridis, K. N., Jun 1 2016, In : Journal of Gastroenterology and Hepatology (Australia). 31, 6, p. 1184-1190 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Targeted next generation sequencing of endoscopic ultrasound acquired cytology from ampullary and pancreatic adenocarcinoma has the potential to aid patient stratification for optimal therapy selection

Gleeson, F. C., Kerr, S. E., Kipp, B. R., Voss, J. S., Minot, D. M., Tu, Z. J., Henry, M. R., Graham, R., Vasmatzis, G., Cheville, J., Lazaridis, K. N. & Levy, M. J., 2016, In : Oncotarget. 7, 34, p. 54526-54536 11 p.

Research output: Contribution to journalArticle

38 Scopus citations
2015

A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease

Eaton, J. E., Juran, B. D., Atkinson, E. J., Schlicht, E. M., Xie, X., De Andrade, M., Lammert, C. S., Luketic, V. A., Odin, J. A., Koteish, A. A., Kowdley, K. V., Chopra, K. B., Hirschfield, G. M., Chalasani, N. P. & Lazaridis, K. N., May 1 2015, In : Alimentary Pharmacology and Therapeutics. 41, 10, p. 980-990 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis

Berntsen, N. L., Klingenberg, O., Juran, B. D., Benito De Valle, M., Lindkvist, B., Lazaridis, K. N., Boberg, K. M., Karlsen, T. H. & Hov, J. R., May 1 2015, In : Gastroenterology. 148, 5, p. 924-927.e2

Research output: Contribution to journalArticle

25 Scopus citations

Association between variants in inflammation and cancer-associated genes and risk and survival of cholangiocarcinoma

Chaiteerakij, R., Juran, B. D., Aboelsoud, M. M., Harmsen, W. S., Moser, C. D., Giama, N. H., Allotey, L. K., Mettler, T. A., Baichoo, E., Zhang, X., Therneau, T. M., Lazaridis, K. N. & Roberts, L. R., Oct 1 2015, In : Cancer Medicine. 4, 10, p. 1599-1602 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Endoscopic ultrasound fine-needle aspiration cytology mutation profiling using targeted next-generation sequencing: personalized care for rectal cancer

Gleeson, F. C., Kipp, B. R., Voss, J. S., Campion, M. B., Minot, D. M., Tu, Z. J., Klee, E. W., Sciallis, A. P., Graham, R., Lazaridis, K. N., Henry, M. R. & Levy, M. J., Jun 1 2015, In : American Journal of Clinical Pathology. 143, 6, p. 879-888 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Frequency of mitogen-activated protein kinase and phosphoinositide 3-kinase signaling pathway pathogenic alterations in EUS-FNA sampled malignant lymph nodes in rectal cancer with theranostic potential

Gleeson, F. C., Kipp, B. R., Voss, J. S., Campion, M. B., Minot, D. M., Tu, Z. J., Klee, E. W., Graham, R., Lazaridis, K. N., Henry, M. R. & Levy, M. J., Sep 1 2015, In : Gastrointestinal Endoscopy. 82, 3, p. 550-556 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Genome-Wide Association Studies in Primary Biliary Cirrhosis

Gulamhusein, A. F., Juran, B. D. & Lazaridis, K. N., Nov 1 2015, In : Seminars in Liver Disease. 35, 4, p. 392-401 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Cordell, H. J., Han, Y., Mells, G. F., Li, Y., Hirschfield, G. M., Greene, C. S., Xie, G., Juran, B. D., Zhu, D., Qian, D. C., Floyd, J. A. B., Morley, K. I., Prati, D., Lleo, A., Cusi, D., Gershwin, M. E., Anderson, C. A., Lazaridis, K. N., Invernizzi, P., Seldin, M. F. & 441 others, Sandford, R. N., Amos, C. I., Siminovitch, K. A., Schlicht, E. M., Lammert, C., Atkinson, E. J., Chan, L. L., De Andrade, M., Balschun, T., Mason, A. L., Myers, R. P., Zhang, J., Milkiewicz, P., Qu, J., Odin, J. A., Luketic, V. A., Bacon, B. R., Bodenheimer, H. C., Liakina, V., Vincent, C., Levy, C., Gregersen, P. K., Almasio, P. L., Alvaro, D., Andreone, P., Andriulli, A., Barlassina, C., Battezzati, P. M., Benedetti, A., Bernuzzi, F., Bianchi, I., Bragazzi, M. C., Brunetto, M., Bruno, S., Casella, G., Coco, B., Colli, A., Colombo, M., Colombo, S., Cursaro, C., Crocè, L. S., Crosignani, A., Donato, M. F., Elia, G., Fabris, L., Ferrari, C., Floreani, A., Foglieni, B., Fontana, R., Galli, A., Lazzari, R., Macaluso, F., Malinverno, F., Marra, F., Marzioni, M., Mattalia, A., Montanari, R., Morini, L., Morisco, F., Mousa Hani, S., Muratori, L., Muratori, P., Niro, G. A., Palmieri, V. O., Picciotto, A., Podda, M., Portincasa, P., Ronca, V., Rosina, F., Rossi, S., Sogno, I., Spinzi, G., Spreafico, M., Strazzabosco, M., Tarallo, S., Tarocchi, M., Tiribelli, C., Toniutto, P., Vinci, M., Zuin, M., Ch'Ng, C. L., Rahman, M., Yapp, T., Sturgess, R., Healey, C., Czajkowski, M., Gunasekera, A., Gyawali, P., Premchand, P., Kapur, K., Marley, R., Foster, G., Watson, A., Dias, A., Subhani, J., Harvey, R., McCorry, R., Ramanaden, D., Gasem, J., Evans, R., Mathialahan, T., Shorrock, C., Lipscomb, G., Southern, P., Tibble, J., Gorard, D., Palegwala, A., Jones, S., Carbone, M., Dawwas, M., Alexander, G., Dolwani, S., Prince, M., Foxton, M., Elphick, D., Mitchison, H., Gooding, I., Karmo, M., Saksena, S., Mendall, M., Patel, M., Ede, R., Austin, A., Sayer, J., Hankey, L., Hovell, C., Fisher, N., Carter, M., Koss, K., Piotrowicz, A., Grimley, C., Neal, D., Lim, G., Levi, S., Ala, A., Broad, A., Saeed, A., Wood, G., Brown, J., Wilkinson, M., Gordon, H., Ramage, J., Ridpath, J., Ngatchu, T., Grover, B., Shaukat, S., Shidrawi, R., Abouda, G., Ali, F., Rees, I., Salam, I., Narain, M., Brown, A., Taylor-Robinson, S., Williams, S., Grellier, L., Banim, P., Das, D., Chilton, A., Heneghan, M., Curtis, H., Gess, M., Drake, I., Aldersley, M., Davies, M., Jones, R., McNair, A., Srirajaskanthan, R., Pitcher, M., Sen, S., Bird, G., Barnardo, A., Kitchen, P., Yoong, K., Chirag, O., Sivaramakrishnan, N., MacFaul, G., Jones, D., Shah, A., Evans, C., Saha, S., Pollock, K., Bramley, P., Mukhopadhya, A., Fraser, A., Mills, P., Shallcross, C., Campbell, S., Bathgate, A., Shepherd, A., Dillon, J., Rushbrook, S., Przemioslo, R., Macdonald, C., Metcalf, J., Shmueli, U., Davis, A., Naqvi, A., Lee, T., Stephen, D., Collier, J., Klass, H., Ninkovic, M., Cramp, M., Sharer, N., Aspinall, R., Goggin, P., Ghosh, D., Douds, A., Hoeroldt, B., Booth, J., Williams, E., Hussaini, H., Stableforth, W., Ayres, R., Thorburn, D., Marshall, E., Burroughs, A., Mann, S., Lombard, M., Richardson, P., Patanwala, I., Maltby, J., Brookes, M., Mathew, R., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Panter, S., Shearman, J., Bray, G., Butcher, G., Forton, D., McLindon, J., Cowan, M., Whatley, G., Mandal, A., Gupta, H., Sanghi, P., Jain, S., Pereira, S., Prasad, G., Watts, G., Wright, M., Neuberger, J., Gordon, F., Unitt, E., Grant, A., Delahooke, T., Higham, A., Brind, A., Cox, M., Ramakrishnan, S., King, A., Collins, C., Whalley, S., Li, A., Fraser, J., Bell, A., Wong, V. S., Singhal, A., Gee, I., Ang, Y., Ransford, R., Gotto, J., Millson, C., Bowles, J., Thomas, C., Harrison, M., Galaska, R., Kendall, J., Whiteman, J., Lawlor, C., Gray, C., Elliott, K., Mulvaney-Jones, C., Hobson, L., Van Duyvenvoorde, G., Loftus, A., Seward, K., Penn, R., Maiden, J., Damant, R., Hails, J., Cloudsdale, R., Silvestre, V., Glenn, S., Dungca, E., Wheatley, N., Doyle, H., Kent, M., Hamilton, C., Braim, D., Wooldridge, H., Abrahams, R., Paton, A., Lancaster, N., Gibbins, A., Hogben, K., Desousa, P., Muscariu, F., Musselwhite, J., McKay, A., Tan, L., Foale, C., Brighton, J., Flahive, K., Nambela, E., Townshend, P., Ford, C., Holder, S., Palmer, C., Featherstone, J., Nasseri, M., Sadeghian, J., Williams, B., Thomas, C., Rolls, S. A., Hynes, A., Duggan, C., Jones, S., Crossey, M., Stansfield, G., MacNicol, C., Wilkins, J., Wilhelmsen, E., Raymode, P., Lee, H. J., Durant, E., Bishop, R., Ncube, N., Tripoli, S., Casey, R., Cowley, C., Miller, R., Houghton, K., Ducker, S., Wright, F., Bird, B., Baxter, G., Keggans, J., Hughes, M., Grieve, E., Young, K., Williams, D., Ocker, K., Hines, F., Martin, K., Innes, C., Valliani, T., Fairlamb, H., Thornthwaite, S., Eastick, A., Tanqueray, E., Morrison, J., Holbrook, B., Browning, J., Walker, K., Congreave, S., Verheyden, J., Slininger, S., Stafford, L., O'Donnell, D., Ainsworth, M., Lord, S., Kent, L., March, L., Dickson, C., Simpson, D., Longhurst, B., Hayes, M., Shpuza, E., White, N., Besley, S., Pearson, S., Wright, A., Jones, L., Gunter, E., Dewhurst, H., Fouracres, A., Farrington, L., Graves, L., Marriott, S., Leoni, M., Tyrer, D., Martin, K., Dali-Kemmery, L., Lambourne, V., Green, M., Sirdefield, D., Amor, K., Colley, J., Shinder, B., Jones, J., Mills, M., Carnahan, M., Taylor, N., Boulton, K., Tregonning, J., Brown, C., Clifford, G., Archer, E., Hamilton, M., Curtis, J., Shewan, T., Walsh, S., Warner, K., Netherton, K., Mupudzi, M., Gunson, B., Gitahi, J., Gocher, D., Batham, S., Pateman, H., Desmennu, S., Conder, J., Clement, D., Gallagher, S., Orpe, J., Chan, P., Currie, L., O'Donohoe, L., Oblak, M., Morgan, L., Quinn, M., Amey, I., Baird, Y., Cotterill, D., Cumlat, L., Winter, L., Greer, S., Spurdle, K., Allison, J., Dyer, S., Sweeting, H. & Kordula, J., Sep 22 2015, In : Nature Communications. 6, 8019.

Research output: Contribution to journalArticle

96 Scopus citations

Kinase genotype analysis of gastric gastrointestinal stromal tumor cytology samples using targeted next-generation sequencing

Gleeson, F. C., Kipp, B. R., Kerr, S. E., Voss, J. S., Graham, R. P., Campion, M. B., Minot, D. M., Tu, Z. J., Klee, E. W., Lazaridis, K. N., Henry, M. R. & Levy, M. J., Jan 1 2015, In : Clinical Gastroenterology and Hepatology. 13, 1, p. 202-206 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Somatic STK11 and concomitant STK11/KRAS mutational frequency in stage IV lung adenocarcinoma adrenal metastases

Gleeson, F. C., Kipp, B. R., Levy, M. J., Voss, J. S., Campion, M. B., Minot, D. M., Tu, Z. J., Klee, E. W., Lazaridis, K. N. & Kerr, S. E., Mar 30 2015, In : Journal of Thoracic Oncology. 10, 3, p. 531-534 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

The cholangiopathies

Lazaridis, K. N. & La Russo, N. F., Jun 1 2015, In : Mayo Clinic Proceedings. 90, 6, p. 791-800 10 p.

Research output: Contribution to journalArticle

94 Scopus citations
2014

Biochemical response to ursodeoxycholic acid predicts survival in a North American cohort of primary biliary cirrhosis patients

Lammert, C., Juran, B. D., Schlicht, E., Chan, L. L., Atkinson, E. J., de Andrade, M. & Lazaridis, K. N., Oct 7 2014, In : Journal of gastroenterology. 49, 10, p. 1414-1420 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Environmental factors in primary biliary cirrhosis

Juran, B. D. & Lazaridis, K. N., Aug 2014, In : Seminars in Liver Disease. 34, 3, p. 265-272 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Implementing individualized medicine into the medical practice

Lazaridis, K. N., MCAllister, T. M., Babovic-Vuksanovic, D., Beck, S. A., Borad, M. J., Bryce, A. H., Chanan-Khan, A. A., Ferber, M. J., Fonseca, R., Johnson, K. J., Klee, E. W., Lindor, N. M., MCCormick, J. B., MCWilliams, R. R., Parker, A. S., Riegert-Johnson, D. L., Rohrer Vitek, C. R., Schahl, K. A., Schultz, C., Stewart, K. & 3 others, Then, G. C., Wieben, E. D. & Farrugia, G., Mar 2014, In : American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 166, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma

Borad, M. J., Champion, M. D., Egan, J. B., Liang, W. S., Fonseca, R., Bryce, A. H., McCullough, A. E., Barrett, M. T., Hunt, K., Patel, M. D., Young, S. W., Collins, J. M., Silva, A. C., Condjella, R. M., Block, M., McWilliams, R. R., Lazaridis, K. N., Klee, E. W., Bible, K. C., Harris, P. & 29 others, Oliver, G. R., Bhavsar, J. D., Nair, A. A., Middha, S., Asmann, Y., Kocher, J. P., Schahl, K., Kipp, B. R., Barr Fritcher, E. G., Baker, A., Aldrich, J., Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Phillips, L., McDonald, J., Adkins, J., Mastrian, S. D., Placek, P., Watanabe, A. T., LoBello, J., Han, H., Von Hoff, D., Craig, D. W., Stewart, A. K. & Carpten, J. D., Feb 1 2014, In : PLoS genetics. 10, 2, e1004135.

Research output: Contribution to journalArticle

165 Scopus citations

Lung cancer adrenal gland metastasis: Optimal fine-needle aspirate and touch preparation smear cellularity characteristics for successful theranostic next-generation sequencing

Gleeson, F. C., Kipp, B. R., Levy, M. J., Voss, J. S., Campion, M. B., Minot, D. M., Tu, Z. J., Klee, E. W., Lazaridis, K. N. & Kerr, S. E., Nov 1 2014, In : Cancer Cytopathology. 122, 11, p. 822-832 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Novel de novo heterozygous FGFR1 mutation in two siblings with Hartsfield syndrome: A case of gonadal mosaicism

Dhamija, R., Kirmani, S., Wang, X., Ferber, M. J., Wieben, E. D., Lazaridis, K. N. & Babovic-Vuksanovic, D., Sep 2014, In : American Journal of Medical Genetics, Part A. 164, 9, p. 2356-2359 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Reduced coffee consumption among individuals with primary sclerosing cholangitis but not primary biliary cirrhosis

Lammert, C., Juran, B. D., Schlicht, E., Xie, X., Atkinson, E. J., De Andrade, M. & Lazaridis, K. N., Sep 2014, In : Clinical Gastroenterology and Hepatology. 12, 9, p. 1562-1568 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease

Næss, S., Björnsson, E., Anmarkrud, J. A., Mamari, S. A., Juran, B. D., Lazaridis, K. N., Chapman, R., Bergquist, A., Melum, E., Marsh, S. G. E., Schrumpf, E., Lie, B. A., Boberg, K. M., Karlsen, T. H. & Hov, J. R., Nov 1 2014, In : Liver International. 34, 10, p. 1488-1495 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Liu, J. Z., Hov, J. R., Folseraas, T., Ellinghaus, E., Rushbrook, S. M., Doncheva, N. T., Andreassen, O. A., Weersma, R. K., Weismüller, T. J., Eksteen, B., Invernizzi, P., Hirschfield, G. M., Gotthardt, D. N., Pares, A., Ellinghaus, D., Shah, T., Juran, B. D., Milkiewicz, P., Rust, C., Schramm, C. & 64 others, Muler, T., Srivastava, B., Dalekos, G., Nöthen, M. M., Herms, S., Winkelmann, J., Mitrovic, M., Braun, F., Ponsioen, C. Y., Croucher, P. J. P., Sterneck, M., Teufel, A., Andrew L Mason, L. M., Saarela, J., Leppa, V., Dorfman, R., Alvaro, D., Floreani, A., Onengut-Gumuscu, S., Rich, S. S., Thompson, W. K., Schork, A. J., Næss, S., Thomsen, I., Mayr, G., König, I. R., Hveem, K., Cleynen, I., Gutierrez-Achury, J., Ricaño-Ponce, I., Van Heel, D., Björnsson, E., Sandford, R. N., Durie, P. R., Melum, E., Vatn, M. H., Silverberg, M. S., Duerr, R. H., Padyukov, L., Brand, S., Sans, M., Annese, V., Achkar, J. P., Boberg, K. M., Marschall, H. U., Chazouillères, O., Bowlus, C. L., Wijmenga, C., Schrumpf, E., Vermeire, S., Albrecht, M., Rioux, J. D., Alexander, G., Bergquist, A., Cho, J., Schreiber, S., Manns, M. P., Färkkilä, M., Dale, A. M., Chapman, R. W., Konstantinos N Lazaridis, N. L., Franke, A., Anderson, C. A. & Karlsen, T. H., Jun 1 2013, In : Nature Genetics. 45, 6, p. 670-675 6 p.

Research output: Contribution to journalArticle

201 Scopus citations

Efficacy and safety of transarterial radioembolization versus chemoembolization in patients with hepatocellular carcinoma

Moreno-Luna, L. E., Yang, J. D., Sanchez, W., Paz-Fumagalli, R., Harnois, D. M., Mettler, T. A., Gansen, D. N., De Groen, P. C., Lazaridis, K. N., Narayanan Menon, K. V., Larusso, N. F., Alberts, S. R., Gores, G. J., Fleming, C. J., Slettedahl, S. W., Harmsen, W. S., Therneau, T. M., Wiseman, G. A., Andrews, J. C. & Roberts, L. R., Jun 1 2013, In : Cardiovascular and Interventional Radiology. 36, 3, p. 714-723 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Questionnaire based assessment of risk factors for primary biliary cirrhosis

Lammert, C., Nguyen, D. L., Juran, B. D., Schlicht, E., Larson, J. J., Atkinson, E. J. & Lazaridis, K. N., Jul 1 2013, In : Digestive and Liver Disease. 45, 7, p. 589-594 6 p.

Research output: Contribution to journalArticle

24 Scopus citations