Konstantinos N Lazaridis, MD, FACP, AGAF

  • 5321 Citations
  • 37 Scopus h-Index
1993 …2019
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Research Output 1993 2019

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Article
2019

Clinical Applications and Utility of a Precision Medicine Approach for Patients With Unexplained Cytopenias

Mangaonkar, A. A., Ferrer, A., Pinto e Vairo, F., Cousin, M. A., Kuisle, R. J., Gangat, N., Hogan, W. J., Litzow, M. R., McAllister, T. M., Klee, E. W., Lazaridis, K. N., Stewart, A. K. & Patnaik, M. M., Jan 1 2019, In : Mayo Clinic proceedings.

Research output: Contribution to journalArticle

Precision Medicine
Exome
Poisons
Hematopoietic Stem Cell Transplantation
Cell Lineage
3 Citations (Scopus)
Ursodeoxycholic Acid
Cholangitis
Transplants
Survival
Therapeutics
4 Citations (Scopus)

Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning

Eaton, J. E., Vesterhus, M., McCauley, B. M., Atkinson, E. J., Schlicht, E. M., Juran, B. D., Gossard, A. A., La Russo, N. F., Gores, G. J., Karlsen, T. H. & Lazaridis, K. N., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Validation Studies
Confidence Intervals
Bilirubin
Alkaline Phosphatase
2018
13 Citations (Scopus)

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis

Müller, T., Alberts, R., De Vries, E. M. G., Goode, E. C., Jiang, X., Sampaziotis, F., Rombouts, K., Böttcher, K., Folseraas, T., Weismüller, T. J., Mason, A. L., Wang, W., Alexander, G., Alvaro, D., Bergquist, A., Björkström, N. K., Beuers, U., Björnsson, E., Boberg, K. M., Bowlus, C. L. & 54 others, Bragazzi, M. C., Carbone, M., Chazouillères, O., Cheung, A., Dalekos, G., Eaton, J., Eksteen, B., Ellinghaus, D., Färkkilä, M., Festen, E. A. M., Floreani, A., Franceschet, I., Gotthardt, D. N., Hirschfield, G. M., Hoek, B. V., Holm, K., Hohenester, S., Hov, J. R., Imhann, F., Invernizzi, P., Juran, B. D., Lenzen, H., Lieb, W., Liu, J. Z., Marschall, H. U., Marzioni, M., Melum, E., Milkiewicz, P., Pares, A., Rupp, C., Rust, C., Sandford, R. N., Schramm, C., Schreiber, S., Schrumpf, E., Silverberg, M. S., Srivastava, B., Sterneck, M., Teufel, A., Vallier, L., Verheij, J., Vila, A. V., De Vries, B., Zachou, K., Chapman, R. W., Manns, M. P., Pinzani, M., Rushbrook, S. M., Lazaridis, K. N., Franke, A., Anderson, C. A., Karlsen, T. H., Ponsioen, C. Y. & Weersma, R. K., Aug 1 2018, In : Gut. 67, 8, p. 1517-1524 8 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Disease Progression
Liver
Transplants
Survival
2 Citations (Scopus)

Metabolomic profiling of portal blood and bile reveals metabolic signatures of primary sclerosing cholangitis

Tietz-Bogert, P. S., Kim, M., Cheung, A., Tabibian, J. H., Heimbach, J. K., Rosen, C. B., Nandakumar, M., Lazaridis, K. N., La Russo, N. F., Sung, J. & O’hara, S. P., Oct 16 2018, In : International Journal of Molecular Sciences. 19, 10, 3188.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Metabolomics
metabolites
Bile
serums
1 Citation (Scopus)
Pharmacogenetics
Patient Rights
Practice Guidelines
Prescriptions
Costs and Cost Analysis
2 Citations (Scopus)

PNPLA3 association with alcoholic liver disease in a cohort of heavy drinkers

Kolla, B. P., Schneekloth, T. D., Biernacka, J. M., Shah, V., Lazaridis, K. N., Geske, J. & Karpyak, V. M., Jan 1 2018, In : Alcohol and Alcoholism. 53, 4, p. 357-360 4 p.

Research output: Contribution to journalArticle

Alcoholic Liver Diseases
Liver
Polymorphism
Single Nucleotide Polymorphism
Nucleotides

Primary biliary cholangitis, DNA, and beyond: The Relative contribution of genes

Gulamhusein, A. F. & Lazaridis, K. N., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Cholangitis
DNA
Genes
2017
1 Citation (Scopus)

Doublecortin domain containing protein 2 (DCDC2) genetic variants in primary sclerosing cholangitis

Cheung, A. C., Juran, B. D., Moore, R. M., La Russo, N. F. & Lazaridis, K. N., 2017, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Protein Domains
4 Citations (Scopus)

Emerging pharmacologic therapies for primary sclerosing cholangitis

Cheung, A. C., Lazaridis, K. N., La Russo, N. F. & Gores, G. J., Mar 2 2017, (Accepted/In press) In : Current Opinion in Gastroenterology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Immunomodulation
Microbiota
Pharmaceutical Preparations
Liver Transplantation
9 Citations (Scopus)

Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis

Cheung, A. C., La Russo, N. F., Gores, G. J. & Lazaridis, K. N., May 1 2017, In : Seminars in Liver Disease. 37, 2, p. 159-174 16 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Cholangitis
Epigenomics
Genes
Genome-Wide Association Study
13 Citations (Scopus)

Experience with precision genomics and tumor board, indicates frequent target identification, but barriers to delivery

Bryce, A. H., Egan, J. B., Borad, M. J., Stewart, A. K., Nowakowski, G. S., Chanan Khan, A. A., Patnaik, M. M., Ansell, S. M., Banck, M. S., Robinson, S., Mansfield, A., Klee, E. W., Oliver, G. R., McCormick, J. B., Huneke, N. E., Tagtow, C. M., Jenkins, R. B., Rumilla, K. M., Kerr, S. E., Kocher, J-P. & 5 others, Beck, S. A., Fernandez-Zapico, M. E., Farrugia, G., Lazaridis, K. N. & Mc Williams, R. R., 2017, In : Oncotarget. 8, 16, p. 27145-27154 10 p.

Research output: Contribution to journalArticle

Genomics
Neoplasms
Precision Medicine
Standard of Care
Therapeutics

HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry

The UK-PSC Consortium, Oct 1 2017, In : HLA. 90, 4, p. 228-233 6 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
HLA Antigens
Haplotypes
Alleles
Population
4 Citations (Scopus)

Improving Therapeutic Odyssey: Preemptive Pharmacogenomics Utility in Patient Care

Lazaridis, K. N., Jan 1 2017, In : Clinical Pharmacology and Therapeutics. 101, 1, p. 39-41 3 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Patient Care
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
Drug Therapy
99 Citations (Scopus)

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis

on behalf of the & International PSC Study Group, Jun 1 2017, In : Gastroenterology. 152, 8, p. 1975-1984.e8

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Inflammatory Bowel Diseases
Phenotype
Liver Transplantation
Neoplasms
4 Citations (Scopus)

Pharmacogenomic findings from clinical whole exome sequencing of diagnostic odyssey patients

Cousin, M. A., Matey, E. T., Blackburn, P. R., Boczek, N. J., McAllister, T. M., Kruisselbrink, T. M., Babovic-Vuksanovic, D., Lazaridis, K. N. & Klee, E. W., Jan 1 2017, In : Molecular Genetics and Genomic Medicine. 5, 3, p. 269-279 11 p.

Research output: Contribution to journalArticle

Exome
Pharmacogenetics
Precision Medicine
Therapeutic Uses
Pharmacists
3 Citations (Scopus)
T-Cell Lymphoma
Retinoids
Cell Cycle
Peripheral T-Cell Lymphoma
Cutaneous T-Cell Lymphoma
7 Citations (Scopus)

The prevalence of diseases caused by lysosome-related genes in a cohort of undiagnosed patients

Vairo, F. P., Boczek, N. J., Cousin, M. A., Kaiwar, C., Blackburn, P. R., Conboy, E., Lanpher, B., Gavrilova, R. M., Pichurin, P. N., Lazaridis, K. N., Babovic-Vuksanovic, D. & Klee, E. W., Dec 1 2017, In : Molecular Genetics and Metabolism Reports. 13, p. 46-51 6 p.

Research output: Contribution to journalArticle

Lysosomes
Genes
Exome
Precision Medicine
Incidence
8 Citations (Scopus)

Variations in primary sclerosing cholangitis across the age spectrum

Eaton, J. E., McCauley, B. M., Atkinson, E. J., Juran, B. D., Schlicht, E. M., De Andrade, M. & Lazaridis, K. N., Oct 1 2017, In : Journal of Gastroenterology and Hepatology (Australia). 32, 10, p. 1763-1768 6 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Delayed Diagnosis
Early Diagnosis
Confidence Intervals
Cholangiocarcinoma
2016
168 Citations (Scopus)

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

Ellinghaus, D., Jostins, L., Spain, S. L., Cortes, A., Bethune, J., Han, B., Park, Y. R., Raychaudhuri, S., Pouget, J. G., Hübenthal, M., Folseraas, T., Wang, Y., Esko, T., Metspalu, A., Westra, H. J., Franke, L., Pers, T. H., Weersma, R. K., Collij, V., D'Amato, M. & 25 others, Halfvarson, J., Jensen, A. B., Lieb, W., Degenhardt, F., Forstner, A. J., Hofmann, A., Schreiber, S., Mrowietz, U., Juran, B. D., Lazaridis, K. N., Brunak, SØ., Dale, A. M., Trembath, R. C., Weidinger, S., Weichenthal, M., Ellinghaus, E., Elder, J. T., Barker, J. N. W. N., Andreassen, O. A., McGovern, D. P., Karlsen, T. H., Barrett, J. C., Parkes, M., Brown, M. A. & Franke, A., May 1 2016, In : Nature Genetics. 48, 5, p. 510-518 9 p.

Research output: Contribution to journalArticle

Comorbidity
Sclerosing Cholangitis
Chronic Disease
Inflammatory Bowel Diseases
Molecular Pathology
5 Citations (Scopus)

Clinical characteristics and platelet phenotype in a family with RUNX1 mutated thrombocytopenia

Perez Botero, J., Chen, D., Cousin, M. A., Majerus, J. A., Coon, L. M., Kruisselbrink, T. M., Klee, E. W., Lazaridis, K. N., Pruthi, R. K. & Patnaik, M. M., Dec 8 2016, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-5 5 p.

Research output: Contribution to journalArticle

Thrombocytopenia
Blood Platelets
Phenotype
10 Citations (Scopus)

Clinical Implementation of Integrated Genomic Profiling in Patients with Advanced Cancers

Borad, M. J., Egan, J. B., Condjella, R. M., Liang, W. S., Fonseca, R., Ritacca, N. R., McCullough, A. E., Barrett, M., Hunt, K. S., Champion, M. D., Patel, M. D., Young, S. W., Silva, A. C., Ho, T. H., Halfdanarson, T. R., Mc Williams, R. R., Lazaridis, K. N., Ramanathan, R. K., Baker, A., Aldrich, J. & 17 others, Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Cuyugan, L., McDonald, J., Adkins, J., Mastrian, S. D., Valdez, R., Jaroszewski, D. E., Von Hoff, D. D., Craig, D. W., Stewart, A. K., Carpten, J. D. & Bryce, A. H., 2016, In : Scientific Reports. 6, 1, 25.

Research output: Contribution to journalArticle

Neoplasms
Therapeutics
DNA Fingerprinting
Patient Preference
Pharmaceutical Preparations
29 Citations (Scopus)

Duration of inflammatory bowel disease is associated with increased risk of cholangiocarcinoma in patients with primary sclerosing cholangitis and IBD

Gulamhusein, A. F., Eaton, J. E., Tabibian, J. H., Atkinson, E. J., Juran, B. D. & Lazaridis, K. N., May 1 2016, In : American Journal of Gastroenterology. 111, 5, p. 705-711 7 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Cholangiocarcinoma
Inflammatory Bowel Diseases
Colectomy
Proportional Hazards Models
50 Citations (Scopus)

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

The UK-PSC Consortium, The International IBD Genetics Consortium & The International PSC Study Group, Dec 19 2016, (Accepted/In press) In : Nature Genetics.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Genetic Loci
Genome-Wide Association Study
Inflammatory Bowel Diseases
Ulcerative Colitis
8 Citations (Scopus)

Low incidence of primary biliary cirrhosis (PBC) in the first-degree relatives of PBC probands after 8 years of follow-up

Gulamhusein, A. F., Juran, B. D., Atkinson, E. J., Mccauley, B., Schlicht, E. & Lazaridis, K. N., 2016, (Accepted/In press) In : Liver International.

Research output: Contribution to journalArticle

Biliary Liver Cirrhosis
Incidence
Antibodies
Cholestasis
Molecular Epidemiology
3 Citations (Scopus)

Molecular cytology genotyping of primary and metastatic GI stromal tumors by using a custom two-gene targeted next-generation sequencing panel with therapeutic intent

Gleeson, F. C., Kerr, S. E., Kipp, B. R., Voss, J. S., Minot, D. M., Tu, Z. J., Henry, M. R., Vasmatzis, G., Cheville, J. C., Lazaridis, K. N. & Levy, M. J., Jan 24 2016, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

Cell Biology
Surgical Pathology
Mutation
Genes
Neoplasms
51 Citations (Scopus)

Outcome of Whole Exome Sequencing for Diagnostic Odyssey Cases of an Individualized Medicine Clinic: The Mayo Clinic Experience

Lazaridis, K. N., Schahl, K. A., Cousin, M. A., Babovic-Vuksanovic, D., Riegert-Johnson, D. L., Gavrilova, R. M., McAllister, T. M., Lindor, N. M., Abraham, R. S., Ackerman, M. J., Pichurin, P. N., Deyle, D. R., Gavrilov, D. K., Hand, J. L., Klee, E. W., Stephens, M. C., Wick, M. J., Atkinson, E. J., Linden, D. R., Ferber, M. J. & 19 others, Wieben, E. D., Farrugia, G., Baudhuin, L. M., Beck, S. A., Beek, G. J., Go, R. S., Guthrie, K. J., Hovan, M. J., Hunt, K. S., Kemppainen, J. L., Kruisselbrink, T. M., McCormick, J. B., McLaughlin, B. M., Murphree, M. I., Niewold, T. B., Oglesbee, D., Reed, A., Thibodeau, S. N. & Thorland, E. C., Mar 1 2016, In : Mayo Clinic Proceedings. 91, 3, p. 297-307 11 p.

Research output: Contribution to journalArticle

Exome
Precision Medicine
Inborn Genetic Diseases
Insurance Coverage
Medicaid
29 Citations (Scopus)

Performance of magnetic resonance elastography in primary sclerosing cholangitis

Eaton, J. E., Dzyubak, B., Venkatesh, S. K., Smyrk, T. C., Gores, G. J., Ehman, R. L., La Russo, N. F., Gossard, A. A. & Lazaridis, K. N., Jun 1 2016, In : Journal of Gastroenterology and Hepatology (Australia). 31, 6, p. 1184-1190 7 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Sclerosing Cholangitis
Liver
Fibrosis
Alkaline Phosphatase
34 Citations (Scopus)

Targeted next generation sequencing of endoscopic ultrasound acquired cytology from ampullary and pancreatic adenocarcinoma has the potential to aid patient stratification for optimal therapy selection

Gleeson, F. C., Kerr, S. E., Kipp, B. R., Voss, J. S., Minot, D. M., Tu, Z. J., Henry, M. R., Graham, R., Vasmatzis, G., Cheville, J., Lazaridis, K. N. & Levy, M. J., 2016, In : Oncotarget. 7, 34, p. 54526-54536 11 p.

Research output: Contribution to journalArticle

Cell Biology
Adenocarcinoma
Fine Needle Biopsy
Neoplasm Genes
Mutation
2015
17 Citations (Scopus)

A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease

Eaton, J. E., Juran, B. D., Atkinson, E. J., Schlicht, E. M., Xie, X., De Andrade, M., Lammert, C. S., Luketic, V. A., Odin, J. A., Koteish, A. A., Kowdley, K. V., Chopra, K. B., Hirschfield, G. M., Chalasani, N. P. & Lazaridis, K. N., May 1 2015, In : Alimentary Pharmacology and Therapeutics. 41, 10, p. 980-990 11 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Environmental Exposure
Inflammatory Bowel Diseases
Urinary Tract Infections
Smoking
21 Citations (Scopus)

Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis

Berntsen, N. L., Klingenberg, O., Juran, B. D., Benito De Valle, M., Lindkvist, B., Lazaridis, K. N., Boberg, K. M., Karlsen, T. H. & Hov, J. R., May 1 2015, In : Gastroenterology. 148, 5, p. 924-927.e2

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Haplotypes
Immunoglobulin G
Serum
Norway
4 Citations (Scopus)

Association between variants in inflammation and cancer-associated genes and risk and survival of cholangiocarcinoma

Chaiteerakij, R., Juran, B. D., Aboelsoud, M. M., Harmsen, W. S., Moser, C. D., Giama, N. H., Allotey, L. K., Mettler, T. A., Baichoo, E., Zhang, X., Therneau, T. M., Lazaridis, K. N. & Roberts, L. R., Oct 1 2015, In : Cancer Medicine. 4, 10, p. 1599-1602 4 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Neoplasm Genes
Inflammation
Survival
Single Nucleotide Polymorphism
15 Citations (Scopus)

Characterization of endoscopic ultrasound fine-needle aspiration cytology by targeted next-generation sequencing and theranostic potential

Gleeson, F. C., Kipp, B. R., Kerr, S. E., Voss, J. S., Lazaridis, K. N., Katzka, D. A. & Levy, M. J., Jan 1 2015, In : Clinical Gastroenterology and Hepatology. 13, 1, p. 37-41 5 p.

Research output: Contribution to journalArticle

Fine Needle Biopsy
Cell Biology
Neoplasms
High-Throughput Nucleotide Sequencing
Neoplasm Genes
24 Citations (Scopus)

Endoscopic ultrasound fine-needle aspiration cytology mutation profiling using targeted next-generation sequencing: personalized care for rectal cancer

Gleeson, F. C., Kipp, B. R., Voss, J. S., Campion, M. B., Minot, D. M., Tu, Z. J., Klee, E. W., Sciallis, A. P., Graham, R., Lazaridis, K. N., Henry, M. R. & Levy, M. J., Jun 1 2015, In : American Journal of Clinical Pathology. 143, 6, p. 879-888 10 p.

Research output: Contribution to journalArticle

Rectal Neoplasms
Fine Needle Biopsy
Cell Biology
Mutation
Lymph Nodes
3 Citations (Scopus)

Frequency of mitogen-activated protein kinase and phosphoinositide 3-kinase signaling pathway pathogenic alterations in EUS-FNA sampled malignant lymph nodes in rectal cancer with theranostic potential

Gleeson, F. C., Kipp, B. R., Voss, J. S., Campion, M. B., Minot, D. M., Tu, Z. J., Klee, E. W., Graham, R., Lazaridis, K. N., Henry, M. R. & Levy, M. J., Sep 1 2015, In : Gastrointestinal Endoscopy. 82, 3, p. 550-556 7 p.

Research output: Contribution to journalArticle

MAP Kinase Kinase 3
Endoscopic Ultrasound-Guided Fine Needle Aspiration
1-Phosphatidylinositol 4-Kinase
Rectal Neoplasms
Lymph Nodes
25 Citations (Scopus)

Genome-Wide Association Studies in Primary Biliary Cirrhosis

Gulamhusein, A. F., Juran, B. D. & Lazaridis, K. N., Nov 1 2015, In : Seminars in Liver Disease. 35, 4, p. 392-401 10 p.

Research output: Contribution to journalArticle

Biliary Liver Cirrhosis
Genome-Wide Association Study
HLA Antigens
Inborn Genetic Diseases
Linkage Disequilibrium
84 Citations (Scopus)

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Cordell, H. J., Han, Y., Mells, G. F., Li, Y., Hirschfield, G. M., Greene, C. S., Xie, G., Juran, B. D., Zhu, D., Qian, D. C., Floyd, J. A. B., Morley, K. I., Prati, D., Lleo, A., Cusi, D., Gershwin, M. E., Anderson, C. A., Lazaridis, K. N., Invernizzi, P., Seldin, M. F. & 441 others, Sandford, R. N., Amos, C. I., Siminovitch, K. A., Schlicht, E. M., Lammert, C., Atkinson, E. J., Chan, L. L., De Andrade, M., Balschun, T., Mason, A. L., Myers, R. P., Zhang, J., Milkiewicz, P., Qu, J., Odin, J. A., Luketic, V. A., Bacon, B. R., Bodenheimer, H. C., Liakina, V., Vincent, C., Levy, C., Gregersen, P. K., Almasio, P. L., Alvaro, D., Andreone, P., Andriulli, A., Barlassina, C., Battezzati, P. M., Benedetti, A., Bernuzzi, F., Bianchi, I., Bragazzi, M. C., Brunetto, M., Bruno, S., Casella, G., Coco, B., Colli, A., Colombo, M., Colombo, S., Cursaro, C., Crocè, L. S., Crosignani, A., Donato, M. F., Elia, G., Fabris, L., Ferrari, C., Floreani, A., Foglieni, B., Fontana, R., Galli, A., Lazzari, R., Macaluso, F., Malinverno, F., Marra, F., Marzioni, M., Mattalia, A., Montanari, R., Morini, L., Morisco, F., Mousa Hani, S., Muratori, L., Muratori, P., Niro, G. A., Palmieri, V. O., Picciotto, A., Podda, M., Portincasa, P., Ronca, V., Rosina, F., Rossi, S., Sogno, I., Spinzi, G., Spreafico, M., Strazzabosco, M., Tarallo, S., Tarocchi, M., Tiribelli, C., Toniutto, P., Vinci, M., Zuin, M., Ch'Ng, C. L., Rahman, M., Yapp, T., Sturgess, R., Healey, C., Czajkowski, M., Gunasekera, A., Gyawali, P., Premchand, P., Kapur, K., Marley, R., Foster, G., Watson, A., Dias, A., Subhani, J., Harvey, R., McCorry, R., Ramanaden, D., Gasem, J., Evans, R., Mathialahan, T., Shorrock, C., Lipscomb, G., Southern, P., Tibble, J., Gorard, D., Palegwala, A., Jones, S., Carbone, M., Dawwas, M., Alexander, G., Dolwani, S., Prince, M., Foxton, M., Elphick, D., Mitchison, H., Gooding, I., Karmo, M., Saksena, S., Mendall, M., Patel, M., Ede, R., Austin, A., Sayer, J., Hankey, L., Hovell, C., Fisher, N., Carter, M., Koss, K., Piotrowicz, A., Grimley, C., Neal, D., Lim, G., Levi, S., Ala, A., Broad, A., Saeed, A., Wood, G., Brown, J., Wilkinson, M., Gordon, H., Ramage, J., Ridpath, J., Ngatchu, T., Grover, B., Shaukat, S., Shidrawi, R., Abouda, G., Ali, F., Rees, I., Salam, I., Narain, M., Brown, A., Taylor-Robinson, S., Williams, S., Grellier, L., Banim, P., Das, D., Chilton, A., Heneghan, M., Curtis, H., Gess, M., Drake, I., Aldersley, M., Davies, M., Jones, R., McNair, A., Srirajaskanthan, R., Pitcher, M., Sen, S., Bird, G., Barnardo, A., Kitchen, P., Yoong, K., Chirag, O., Sivaramakrishnan, N., MacFaul, G., Jones, D., Shah, A., Evans, C., Saha, S., Pollock, K., Bramley, P., Mukhopadhya, A., Fraser, A., Mills, P., Shallcross, C., Campbell, S., Bathgate, A., Shepherd, A., Dillon, J., Rushbrook, S., Przemioslo, R., Macdonald, C., Metcalf, J., Shmueli, U., Davis, A., Naqvi, A., Lee, T., Stephen, D., Collier, J., Klass, H., Ninkovic, M., Cramp, M., Sharer, N., Aspinall, R., Goggin, P., Ghosh, D., Douds, A., Hoeroldt, B., Booth, J., Williams, E., Hussaini, H., Stableforth, W., Ayres, R., Thorburn, D., Marshall, E., Burroughs, A., Mann, S., Lombard, M., Richardson, P., Patanwala, I., Maltby, J., Brookes, M., Mathew, R., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Panter, S., Shearman, J., Bray, G., Butcher, G., Forton, D., McLindon, J., Cowan, M., Whatley, G., Mandal, A., Gupta, H., Sanghi, P., Jain, S., Pereira, S., Prasad, G., Watts, G., Wright, M., Neuberger, J., Gordon, F., Unitt, E., Grant, A., Delahooke, T., Higham, A., Brind, A., Cox, M., Ramakrishnan, S., King, A., Collins, C., Whalley, S., Li, A., Fraser, J., Bell, A., Wong, V. 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J., Durant, E., Bishop, R., Ncube, N., Tripoli, S., Casey, R., Cowley, C., Miller, R., Houghton, K., Ducker, S., Wright, F., Bird, B., Baxter, G., Keggans, J., Hughes, M., Grieve, E., Young, K., Williams, D., Ocker, K., Hines, F., Martin, K., Innes, C., Valliani, T., Fairlamb, H., Thornthwaite, S., Eastick, A., Tanqueray, E., Morrison, J., Holbrook, B., Browning, J., Walker, K., Congreave, S., Verheyden, J., Slininger, S., Stafford, L., O'Donnell, D., Ainsworth, M., Lord, S., Kent, L., March, L., Dickson, C., Simpson, D., Longhurst, B., Hayes, M., Shpuza, E., White, N., Besley, S., Pearson, S., Wright, A., Jones, L., Gunter, E., Dewhurst, H., Fouracres, A., Farrington, L., Graves, L., Marriott, S., Leoni, M., Tyrer, D., Martin, K., Dali-Kemmery, L., Lambourne, V., Green, M., Sirdefield, D., Amor, K., Colley, J., Shinder, B., Jones, J., Mills, M., Carnahan, M., Taylor, N., Boulton, K., Tregonning, J., Brown, C., Clifford, G., Archer, E., Hamilton, M., Curtis, J., Shewan, T., Walsh, S., Warner, K., Netherton, K., Mupudzi, M., Gunson, B., Gitahi, J., Gocher, D., Batham, S., Pateman, H., Desmennu, S., Conder, J., Clement, D., Gallagher, S., Orpe, J., Chan, P., Currie, L., O'Donohoe, L., Oblak, M., Morgan, L., Quinn, M., Amey, I., Baird, Y., Cotterill, D., Cumlat, L., Winter, L., Greer, S., Spurdle, K., Allison, J., Dyer, S., Sweeting, H. & Kordula, J., Sep 22 2015, In : Nature Communications. 6, 8019.

Research output: Contribution to journalArticle

Biliary Liver Cirrhosis
genome
loci
Meta-Analysis
therapy
23 Citations (Scopus)

Kinase genotype analysis of gastric gastrointestinal stromal tumor cytology samples using targeted next-generation sequencing

Gleeson, F. C., Kipp, B. R., Kerr, S. E., Voss, J. S., Graham, R., Campion, M. B., Minot, D. M., Tu, Z. J., Klee, E. W., Lazaridis, K. N., Henry, M. R. & Levy, M. J., Jan 1 2015, In : Clinical Gastroenterology and Hepatology. 13, 1, p. 202-206 5 p.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Cell Biology
Exons
Stomach
Phosphotransferases
6 Citations (Scopus)

Somatic STK11 and concomitant STK11/KRAS mutational frequency in stage IV lung adenocarcinoma adrenal metastases

Gleeson, F. C., Kipp, B. R., Levy, M. J., Voss, J. S., Campion, M. B., Minot, D. M., Tu, Z. J., Klee, E. W., Lazaridis, K. N. & Kerr, S. E., Mar 30 2015, In : Journal of Thoracic Oncology. 10, 3, p. 531-534 4 p.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Neoplasm Metastasis
Mutation
Epidermal Growth Factor Receptor
Guidelines
90 Citations (Scopus)

The cholangiopathies

Lazaridis, K. N. & La Russo, N. F., Jun 1 2015, In : Mayo Clinic Proceedings. 90, 6, p. 791-800 10 p.

Research output: Contribution to journalArticle

Liver
Transplants
Biliary Atresia
Sclerosing Cholangitis
End Stage Liver Disease
2014
18 Citations (Scopus)

Biochemical response to ursodeoxycholic acid predicts survival in a North American cohort of primary biliary cirrhosis patients

Lammert, C., Juran, B. D., Schlicht, E., Chan, L. L., Atkinson, E. J., De Andrade, M. & Lazaridis, K. N., Oct 7 2014, In : Journal of Gastroenterology. 49, 10, p. 1414-1420 7 p.

Research output: Contribution to journalArticle

Ursodeoxycholic Acid
Biliary Liver Cirrhosis
Survival
Transplants
Alkaline Phosphatase
34 Citations (Scopus)

Environmental factors in primary biliary cirrhosis

Juran, B. D. & Lazaridis, K. N., 2014, In : Seminars in Liver Disease. 34, 3, p. 265-272 8 p.

Research output: Contribution to journalArticle

Biliary Liver Cirrhosis
Molecular Mimicry
Autoimmunity
Urinary Tract Infections
Autoimmune Diseases
10 Citations (Scopus)
Incidental Findings
Medical Genetics
Medicine
38 Citations (Scopus)

Implementing individualized medicine into the medical practice

Lazaridis, K. N., MCAllister, T. M., Babovic-Vuksanovic, D., Beck, S. A., Borad, M. J., Bryce, A. H., Chanan Khan, A. A., Ferber, M. J., Fonseca, R., Johnson, K. J., Klee, E. W., Lindor, N. M., MCCormick, J. B., Mc Williams, R. R., Parker, A., Riegert-Johnson, D. L., Rohrer Vitek, C. R., Schahl, K. A., Schultz, C., Stewart, A. K. & 3 others, Then, G. C., Wieben, E. D. & Farrugia, G., 2014, In : American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 166, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

Precision Medicine
Medicine
Patient Care
Exome
Workflow
153 Citations (Scopus)

Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma

Borad, M. J., Champion, M. D., Egan, J. B., Liang, W. S., Fonseca, R., Bryce, A. H., McCullough, A. E., Barrett, M., Hunt, K., Patel, M. D., Young, S. W., Collins, J. M., Silva, A. C., Condjella, R. M., Block, M. S., Mc Williams, R. R., Lazaridis, K. N., Klee, E. W., Bible, K. C., Harris, P. & 29 others, Oliver, G. R., Bhavsar, J. D., Nair, A. A., Middha, S., Asmann, Y., Kocher, J-P., Schahl, K., Kipp, B. R., Barr Fritcher, E. G., Baker, A., Aldrich, J., Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Phillips, L., McDonald, J., Adkins, J., Mastrian, S. D., Placek, P., Watanabe, A. T., LoBello, J., Han, H., Von Hoff, D., Craig, D. W., Stewart, A. K. & Carpten, J. D., Feb 2014, In : PLoS Genetics. 10, 2, e1004135.

Research output: Contribution to journalArticle

Cholangiocarcinoma
tumor
genomics
drug
inhibitor
35 Citations (Scopus)

Lung cancer adrenal gland metastasis: Optimal fine-needle aspirate and touch preparation smear cellularity characteristics for successful theranostic next-generation sequencing

Gleeson, F. C., Kipp, B. R., Levy, M. J., Voss, J. S., Campion, M. B., Minot, D. M., Tu, Z. J., Klee, E. W., Lazaridis, K. N. & Kerr, S. E., Nov 1 2014, In : Cancer cytopathology. 122, 11, p. 822-832 11 p.

Research output: Contribution to journalArticle

Adrenal Gland Neoplasms
Touch
Needles
Lung Neoplasms
Neoplasm Metastasis
13 Citations (Scopus)

Novel de novo heterozygous FGFR1 mutation in two siblings with Hartsfield syndrome: A case of gonadal mosaicism

Dhamija, R., Kirmani, S., Wang, X., Ferber, M. J., Wieben, E. D., Lazaridis, K. N. & Babovic-Vuksanovic, D., 2014, In : American Journal of Medical Genetics, Part A. 164, 9, p. 2356-2359 4 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 1
Mosaicism
Siblings
Mutation
Parents
17 Citations (Scopus)

Reduced coffee consumption among individuals with primary sclerosing cholangitis but not primary biliary cirrhosis

Lammert, C., Juran, B. D., Schlicht, E., Xie, X., Atkinson, E. J., De Andrade, M. & Lazaridis, K. N., 2014, In : Clinical Gastroenterology and Hepatology. 12, 9, p. 1562-1568 7 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Biliary Liver Cirrhosis
Coffee
Drinking
Nonparametric Statistics
16 Citations (Scopus)

Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease

Næss, S., Björnsson, E., Anmarkrud, J. A., Mamari, S. A., Juran, B. D., Lazaridis, K. N., Chapman, R., Bergquist, A., Melum, E., Marsh, S. G. E., Schrumpf, E., Lie, B. A., Boberg, K. M., Karlsen, T. H. & Hov, J. R., Nov 1 2014, In : Liver International. 34, 10, p. 1488-1495 8 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Inflammatory Bowel Diseases
HLA Antigens
Bile Duct Diseases
2013
191 Citations (Scopus)

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Liu, J. Z., Hov, J. R., Folseraas, T., Ellinghaus, E., Rushbrook, S. M., Doncheva, N. T., Andreassen, O. A., Weersma, R. K., Weismüller, T. J., Eksteen, B., Invernizzi, P., Hirschfield, G. M., Gotthardt, D. N., Pares, A., Ellinghaus, D., Shah, T., Juran, B. D., Milkiewicz, P., Rust, C., Schramm, C. & 64 others, Muler, T., Srivastava, B., Dalekos, G., Nöthen, M. M., Herms, S., Winkelmann, J., Mitrovic, M., Braun, F., Ponsioen, C. Y., Croucher, P. J. P., Sterneck, M., Teufel, A., Andrew L Mason, L. M., Saarela, J., Leppa, V., Dorfman, R., Alvaro, D., Floreani, A., Onengut-Gumuscu, S., Rich, S. S., Thompson, W. K., Schork, A. J., Næss, S., Thomsen, I., Mayr, G., König, I. R., Hveem, K., Cleynen, I., Gutierrez-Achury, J., Ricaño-Ponce, I., Van Heel, D., Björnsson, E., Sandford, R. N., Durie, P. R., Melum, E., Vatn, M. H., Silverberg, M. S., Duerr, R. H., Padyukov, L., Brand, S., Sans, M., Annese, V., Achkar, J. P., Boberg, K. M., Marschall, H. U., Chazouillères, O., Bowlus, C. L., Wijmenga, C., Schrumpf, E., Vermeire, S., Albrecht, M., Rioux, J. D., Alexander, G., Bergquist, A., Cho, J., Schreiber, S., Manns, M. P., Färkkilä, M., Dale, A. M., Chapman, R. W., Lazaridis, K. N., Franke, A., Anderson, C. A. & Karlsen, T. H., Jun 2013, In : Nature Genetics. 45, 6, p. 670-675 6 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Immune System Diseases
Inflammatory Bowel Diseases
Population Control
HLA Antigens