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James L Kirkland, MD, PhD

Professor

  • 8033 Citations
  • 47 h-Index
1973 …2021
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Adipocytes Medicine & Life Sciences
Cell Aging Medicine & Life Sciences
Fats Medicine & Life Sciences
Adipose Tissue Medicine & Life Sciences
Adipogenesis Medicine & Life Sciences
Aging of materials Chemical Compounds
Inflammation Medicine & Life Sciences
Phenotype Medicine & Life Sciences

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Projects 1992 2021

AGING EFFECT ON PREADIPOCYTE DIFFERENTIATION

Kirkland, J. L.

National Institutes of Health

5/15/97 → 3/31/21

Project: Research project › Research Project

Adipogenesis
CCAAT-Enhancer-Binding Protein-alpha
Fats
Adipocytes
Cytokines

Imaging for Cellular Senescence

Kirkland, J. L. & Lowe, V. J.

National Institutes of Health

9/1/15 → 5/31/17

Project: Research project › Exploratory/Developmental Grants

Cell Aging
Electrons
Luminescence
Autopsy
Leg

Senescent Cell Transplantation Model

Kirkland, J. L.

National Institutes of Health

8/15/15 → 5/31/17

Project: Research project › Exploratory/Developmental Grants

Cell Transplantation
Cell Aging
Chronic Disease
Glucose Intolerance
Pharmaceutical Preparations

Geroscience Network

Kirkland, J. L.

National Institutes of Health

9/30/13 → 6/30/16

Project: Research project › Resource-Related Research Projects

Chronic Disease
Curriculum
Organized Financing
Health Care Costs
Publications

Cellular Senescence and Aging

Kirkland, J. L., Lebrasseur, N., Deursen, J., Campisi, J., Mooney, S. D. & LeBrasseur, N. K.

National Institutes of Health

5/1/12 → 4/30/17

Project: Research project › Research Program Projects

Cell Aging
Phenotype
Advisory Committees
Research
Fats

Research Output 1973 2018

3 Citations

Cellular Senescence Biomarker p16 INK4a + Cell Burden in Thigh Adipose is Associated with Poor Physical Function in Older Women

Justice, J. N., Gregory, H., Tchkonia, T., Lebrasseur, N. K., Kirkland, J. L., Kritchevsky, S. B. & Nicklas, B. J., Jun 14 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 7, p. 939-945 7 p.

Research output: Contribution to journal › Article

Cell Aging
Thigh
Biomarkers
Caloric Restriction
Resistance Training
3 Citations

Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis

Khosla, S., Farr, J. N. & Kirkland, J. L., Apr 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 4, p. 1282-1290 9 p.

Research output: Contribution to journal › Article

Cell Aging
Osteoporosis
Bone and Bones
Therapeutics
Osteoporotic Fractures
1 Citations

Premature physiologic aging as a paradigm for understanding increased risk of adverse health across the lifespan of survivors of childhood cancer

Ness, K. K., Kirkland, J. L., Monica Gramatges, M., Wang, Z., Kundu, M., McCastlain, K., Li-Harms, X., Zhang, J., Tchkonia, T., Francesca Pluijm, S. M. & Armstrong, G. T., Jul 20 2018, In : Journal of Clinical Oncology. 36, 21, p. 2206-2215 10 p.

Research output: Contribution to journal › Review article

Premature Aging
Survivors
Health
Neoplasms
Research
8 Citations

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice

Moncsek, A., Al-Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., Zhu, Y., Tchkonia, T., Kirkland, J. L., Gores, G. J., Müllhaupt, B., LaRusso, N. F. & Mertens, J. C., Jan 1 2018, In : Hepatology. 67, 1, p. 247-259 13 p.

Research output: Contribution to journal › Article

MDR Genes
Gene Knockout Techniques
B-Cell Lymphoma
Fibrosis
Fibroblasts
18 Citations

17α-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization

Stout, M. B. , Steyn, F. J. , Jurczak, M. J. , Camporez, J. P. G. , Zhu, Y. , Hawse, J. R. , Jurk, D. , Palmer, A. K. , Xu, M. , Pirtskhalava, T. , Evans, G. L. , De Souza Santos, R. , Frank, A. P. , White, T. A. , Monroe, D. G. , Singh, R. J. , Casaclang-Verzosa, G. , Miller, J. D. , Clegg, D. J. , LeBrasseur, N. K. & 4 others Von Zglinicki, T., Shulman, G. I., Tchkonia, T. & Kirkland, J. L., 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 1, p. 3-15 13 p.

Research output: Contribution to journal › Article

Feminization
Intra-Abdominal Fat
Estradiol
Adiposity
Glucose