• 13403 Citations
  • 60 Scopus h-Index
1973 …2020

Research output per year

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Research Output

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Review article
2020

Accelerating the search for interventions aimed at expanding the health span in humans: The role of epidemiology

Newman, A. B., Kritchevsky, S. B., Guralnik, J. M., Cummings, S. R., Salive, M., Kuchel, G. A., Schrack, J., Morris, M. C., Weir, D., Baccarelli, A., Murabito, J. M., Ben-Shlomo, Y., Espeland, M. A., Kirkland, J., Melzer, D. & Ferrucci, L., Jan 1 2020, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 1, p. 77-86 10 p.

Research output: Contribution to journalReview article

Reducing Senescent Cell Burden in Aging and Disease

Pignolo, R. J., Passos, J. F., Khosla, S., Tchkonia, T. & Kirkland, J. L., Jan 1 2020, (Accepted/In press) In : Trends in Molecular Medicine.

Research output: Contribution to journalReview article

Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases

Song, S., Lam, E. W. F., Tchkonia, T., Kirkland, J. L. & Sun, Y., Jan 1 2020, (Accepted/In press) In : Trends in biochemical sciences.

Research output: Contribution to journalReview article

The role of cellular senescence in ageing and endocrine disease

Khosla, S., Farr, J. N., Tchkonia, T. & Kirkland, J. L., May 1 2020, In : Nature Reviews Endocrinology. 16, 5, p. 263-275 13 p.

Research output: Contribution to journalReview article

1 Scopus citations
2019

Cellular senescence: at the nexus between ageing and diabetes

Palmer, A. K., Gustafson, B., Kirkland, J. L. & Smith, U., Oct 1 2019, In : Diabetologia. 62, 10, p. 1835-1841 7 p.

Research output: Contribution to journalReview article

9 Scopus citations

Mixing old and young: Enhancing rejuvenation and accelerating aging

Lau, A., Kennedy, B. K., Kirkland, J. L. & Tullius, S. G., Jan 2 2019, In : Journal of Clinical Investigation. 129, 1, CI123946.

Research output: Contribution to journalReview article

6 Scopus citations

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

Prata, L. G. P. L., Ovsyannikova, I. G., Tchkonia, T. & Kirkland, J. L., Jan 1 2019, In : Seminars in immunology.

Research output: Contribution to journalReview article

13 Scopus citations

The enigmatic role of growth hormone in age-related diseases, cognition, and longevity

Colon, G., Saccon, T., Schneider, A., Cavalcante, M. B., Huffman, D. M., Berryman, D., List, E., Ikeno, Y., Musi, N., Bartke, A., Kopchick, J., Kirkland, J. L., Tchkonia, T. & Masternak, M. M., Dec 1 2019, In : GeroScience. 41, 6, p. 759-774 16 p.

Research output: Contribution to journalReview article

3 Scopus citations
2018

Premature physiologic aging as a paradigm for understanding increased risk of adverse health across the lifespan of survivors of childhood cancer

Ness, K. K., Kirkland, J. L., Monica Gramatges, M., Wang, Z., Kundu, M., McCastlain, K., Li-Harms, X., Zhang, J., Tchkonia, T., Francesca Pluijm, S. M. & Armstrong, G. T., Jul 20 2018, In : Journal of Clinical Oncology. 36, 21, p. 2206-2215 10 p.

Research output: Contribution to journalReview article

16 Scopus citations
2017

Biology of premature ageing in survivors of cancer

Cupit-Link, M. C., Kirkland, J. L., Ness, K. K., Armstrong, G. T., Tchkonia, T., LeBrasseur, N. K., Armenian, S. H., Ruddy, K. J. & Hashmi, S. K., Dec 1 2017, In : ESMO Open. 2, 5, e000250.

Research output: Contribution to journalReview article

35 Scopus citations

Physiological aging: Links among adipose tissue dysfunction, diabetes, and frailty

Stout, M. B., Justice, J. N., Nicklas, B. J. & Kirkland, J. L., Jan 1 2017, In : Physiology. 32, 1, p. 9-19 11 p.

Research output: Contribution to journalReview article

53 Scopus citations
2016

Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction

Xu, M., Tchkonia, T. & Kirkland, J. L., Sep 1 2016, In : Pharmacological Research. 111, p. 152-154 3 p.

Research output: Contribution to journalReview article

17 Scopus citations

Strategies and Challenges in Clinical Trials Targeting Human Aging

Newman, J. C., Milman, S., Hashmi, S. K., Austad, S. N., Kirkland, J. L., Halter, J. B. & Barzilai, N., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1424-1434 11 p.

Research output: Contribution to journalReview article

59 Scopus citations
2014

A systems biology approach to the effect of aging, immunosenescence and vaccine response

Poland, G. A., Ovsyannikova, I. G., Kennedy, R. B., Lambert, N. D. & Kirkland, J. L., Aug 2014, In : Current Opinion in Immunology. 29, 1, p. 62-68 7 p.

Research output: Contribution to journalReview article

49 Scopus citations

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

Zhu, Y., Armstrong, J. L., Tchkonia, T. & Kirkland, J. L., Jul 2014, In : Current opinion in clinical nutrition and metabolic care. 17, 4, p. 324-328 5 p.

Research output: Contribution to journalReview article

114 Scopus citations

Senescence and apoptosis: Dueling or complementary cell fates?

Childs, B. G., Baker, D. J., Kirkland, J. L., Campisi, J. & Van Deursen, J. M., Nov 1 2014, In : EMBO Reports. 15, 11, p. 1139-1153 15 p.

Research output: Contribution to journalReview article

233 Scopus citations
2013

Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities

Tchkonia, T., Zhu, Y., Van Deursen, J., Campisi, J. & Kirkland, J. L., Mar 1 2013, In : Journal of Clinical Investigation. 123, 3, p. 966-972 7 p.

Research output: Contribution to journalReview article

669 Scopus citations

Mechanisms and metabolic implications of regional differences among fat depots

Tchkonia, T., Thomou, T., Zhu, Y., Karagiannides, I., Pothoulakis, C., Jensen, M. D. & Kirkland, J. L., May 7 2013, In : Cell Metabolism. 17, 5, p. 644-656 13 p.

Research output: Contribution to journalReview article

255 Scopus citations

Translating advances from the basic biology of aging into clinical application

Kirkland, J. L., Jan 1 2013, In : Experimental Gerontology. 48, 1, p. 1-5 5 p.

Research output: Contribution to journalReview article

67 Scopus citations
2010

Aging and regional differences in fat cell progenitors - A mini-review

Sepe, A., Tchkonia, T., Thomou, T., Zamboni, M. & Kirkland, J. L., Dec 1 2010, In : Gerontology. 57, 1, p. 66-75 10 p.

Research output: Contribution to journalReview article

115 Scopus citations

Fat tissue, aging, and cellular senescence

Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D. & Kirkland, J. L., Oct 1 2010, In : Aging Cell. 9, 5, p. 667-684 18 p.

Research output: Contribution to journalReview article

449 Scopus citations
2002

Adipogenesis and aging: Does aging make fat go MAD?

Kirkland, J. L., Tchkonia, T., Pirtskhalava, T., Han, J. & Karagiannides, I., Jun 1 2002, In : Experimental Gerontology. 37, 6, p. 757-767 11 p.

Research output: Contribution to journalReview article

229 Scopus citations

The biology of senescence: Potential for prevention of disease

Kirkland, J. L., Aug 1 2002, In : Clinics in Geriatric Medicine. 18, 3, p. 383-405 23 p.

Research output: Contribution to journalReview article

21 Scopus citations
2001

Different fat depots are distinct mini-organs

Tchkonia, T., Karagiannides, I., Armour Forse, R. & Kirkland, J. L., Jan 1 2001, In : Current Opinion in Endocrinology and Diabetes. 8, 5, p. 227-234 8 p.

Research output: Contribution to journalReview article

12 Scopus citations
1998

Inhibitors of preadipocyte replication: opportunities for the treatment of obesity.

Kirkland, J. L. & Hollenberg, C. H., 1998, In : Progress in molecular and subcellular biology. 20, p. 177-195 19 p.

Research output: Contribution to journalReview article

6 Scopus citations
1997
82 Scopus citations
1992

The biochemistry of mammalian senescence

Kirkland, J. L., Apr 1992, In : Clinical Biochemistry. 25, 2, p. 61-75 15 p.

Research output: Contribution to journalReview article

22 Scopus citations
1989

Evolution and ageing

Kirkland, J. L., Jan 1 1989, In : Genome. 31, 1, p. 398-405 8 p.

Research output: Contribution to journalReview article

10 Scopus citations