• 12341 Citations
  • 59 Scopus h-Index
1973 …2021

Research output per year

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Research Output

2020

Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology

Newman, A. B., Kritchevsky, S. B., Guralnik, J. M., Cummings, S. R., Salive, M., Kuchel, G. A., Schrack, J., Morris, M. C., Weir, D., Baccarelli, A., Murabito, J. M., Ben-Shlomo, Y., Espeland, M. A., Kirkland, J., Melzer, D. & Ferrucci, L., Jan 1 2020, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 75, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice

Cavalcante, M. B., Saccon, T. D., Nunes, A. D. C., Kirkland, J. L., Tchkonia, T., Schneider, A. & Masternak, M. M., Jan 18 2020, In : Aging. 12, 3, p. 2711-2722 12 p.

Research output: Contribution to journalArticle

Transplanting cells from old but not young donors causes physical dysfunction in older recipients

Wang, B., Liu, Z., Chen, V. P., Wang, L., Inman, C. L., Zhou, Y., Guo, C., Tchkonia, T., Rowe, D. W., Kuchel, G. A., Robson, P., Kirkland, J. L. & Xu, M., Jan 1 2020, (Accepted/In press) In : Aging Cell. e13106.

Research output: Contribution to journalArticle

Open Access
2019

Aged-senescent cells contribute to impaired heart regeneration

Lewis-McDougall, F. C., Ruchaya, P. J., Domenjo-Vila, E., Shin Teoh, T., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., Tchkonia, T., Kirkland, J. L. & Ellison-Hughes, G. M., Jun 1 2019, In : Aging Cell. 18, 3, e12931.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Cellular senescence: at the nexus between ageing and diabetes

Palmer, A. K., Gustafson, B., Kirkland, J. L. & Smith, U., Jan 1 2019, (Accepted/In press) In : Diabetologia.

Research output: Contribution to journalReview article

4 Scopus citations

Creating the Next Generation of Translational Geroscientists

Newman, J. C., Sokoloski, J. L., Robbins, P. D., Niedernhofer, L. J., Reed, M. J., Wei, J., Austad, S. N., Barzilai, N., Cohen, H. J., Kuchel, G. A., Kirkland, J. L. & Pignolo, R., Jan 1 2019, In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Hyperoxia-induced cellular senescence in fetal airway smooth muscle cells

Parikh, P., Britt, R. J., Manlove, L. J., Wicher, S. A., Roesler, A., Ravix, J., Teske, J., Thompson, M. A., Sieck, G. C., Kirkland, J. L., LeBrasseur, N. K., Tschumperlin, D. J., Pabelick, C. M. & Prakash, Y. S., Jan 1 2019, In : American journal of respiratory cell and molecular biology. 61, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

Kim, S. R., Jiang, K., Ogrodnik, M., Chen, X., Zhu, X. Y., Lohmeier, H., Ahmed, L., Tang, H., Tchkonia, T., Hickson, L., Kirkland, J. L. & Lerman, L. O., Jan 1 2019, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

5 Scopus citations

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

Farr, J. N., Rowsey, J. L., Eckhardt, B. A., Thicke, B. S., Fraser, D. G., Tchkonia, T., Kirkland, J. L., Monroe, D. G. & Khosla, S., Jan 1 2019, In : Journal of Bone and Mineral Research. 34, 8, p. 1407-1418 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., Proctor, C., Correia-Melo, C., Victorelli, S., Fielder, E., Berlinguer-Palmini, R., Owens, A., Greaves, L. C., Kolsky, K. L., Parini, A., Douin-Echinard, V. & 14 others, LeBrasseur, N. K., Arthur, H. M., Tual-Chalot, S., Schafer, M. J., Roos, C. M., Miller, J. D., Robertson, N., Mann, J., Adams, P. D., Tchkonia, T., Kirkland, J. L., Mialet-Perez, J., Richardson, G. D. & Passos, J., Mar 1 2019, In : EMBO Journal. 38, 5, e100492.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Mixing old and young: Enhancing rejuvenation and accelerating aging

Lau, A., Kennedy, B. K., Kirkland, J. L. & Tullius, S. G., Jan 2 2019, In : Journal of Clinical Investigation. 129, 1, CI123946.

Research output: Contribution to journalReview article

5 Scopus citations

Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series

Hurria, A., Carpenter, C. R., McFarland, F., Lundebjerg, N. E., de Cabo, R., Ferrucci, L., Studenski, S. A., Barzilai, N., Briggs, J. P., Ix, J. H., Kitzman, D. W., Kuchel, G. A., Musi, N., Newman, J. C., Rando, T. A., Smith, A. K., Walston, J. D., Kirkland, J. L. & Yung, R., Jan 1 2019, In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

6 Scopus citations

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., Podgorni, O., Enikolopov, G., Johnson, K. O., Xu, M., Inman, C., Palmer, A. K., Schafer, M., Weigl, M., Ikeno, Y., Burns, T. C. & 4 others, Passos, J., von Zglinicki, T., Kirkland, J. L. & Jurk, D., Jan 1 2019, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

9 Scopus citations

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., Podgorni, O., Enikolopov, G., Johnson, K. O., Xu, M., Inman, C., Palmer, A. K., Schafer, M., Weigl, M., Ikeno, Y., Burns, T. C. & 4 others, Passos, J., von Zglinicki, T., Kirkland, J. L. & Jurk, D., May 7 2019, In : Cell Metabolism. 29, 5, p. 1061-1077.e8

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Phases of Metabolic and Soft Tissue Changes in Months Preceding a Diagnosis of Pancreatic Ductal Adenocarcinoma

Sah, R. P., Sharma, A., Nagpal, S., Patlolla, S. H., Sharma, A., Kandlakunta, H., Anani, V., Angom, R. S., Kamboj, A. K., Ahmed, N., Mohapatra, S., Vivekanandhan, S., Philbrick, K. A., Weston, A., Takahashi, N. M., Kirkland, J. L., Javeed, N., Matveyenko, A. V., Levy, M. J., Mukhopadhyay, D. & 1 others, Chari, S. T., May 1 2019, In : Gastroenterology. 156, 6, p. 1742-1752 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Sarcopenia: Aging-related loss of muscle mass and function

Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L. & Sandri, M., Jan 1 2019, In : Physiological Reviews. 99, 1, p. 427-511 85 p.

Research output: Contribution to journalArticle

47 Scopus citations

Senescence marker activin A is increased in human diabetic kidney disease: Association with kidney function and potential implications for therapy

Bian, X., Griffin, T. P., Zhu, X., Islam, M. N., Conley, S. M., Eirin, A., Tang, H., O'Shea, P. M., Palmer, A. K., McCoy, R. G., Herrmann, S. M., Mehta, R. A., Woollard, J. R., Rule, A. D., Kirkland, J. L., Tchkonia, T., Textor, S. C., Griffin, M. D., Lerman, L. O. & Hickson, L. T. J., Dec 15 2019, In : BMJ Open Diabetes Research and Care. 7, 1, e000720.

Research output: Contribution to journalArticle

Open Access

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

Prata, L. G. P. L., Ovsyannikova, I. G., Tchkonia, T. & Kirkland, J. L., Jan 1 2019, In : Seminars in immunology.

Research output: Contribution to journalReview article

6 Scopus citations

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N. & Kirkland, J. L., Jan 1 2019, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

81 Scopus citations

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Suvakov, S., Cubro, H., White, W. M., Butler Tobah, Y. S., Weissgerber, T. L., Jordan, K. L., Zhu, X. Y., Woollard, J. R., Chebib, F., Milic, N. M., Grande, J. P., Xu, M., Tchkonia, T., Kirkland, J. L., Lerman, L. O. & Garovic, V. D., Sep 14 2019, In : Biology of Sex Differences. 10, 1, 49.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang-Verzosa, G., Johnson, K. O., Cubro, H., Doornebal, E. J., Ogrodnik, M., Jurk, D., Jensen, M. D., Chini, E. N., Miller, J. D., Matveyenko, A. V., Stout, M. B. & 13 others, Schafer, M. J., White, T. A., Hickson, L., Demaria, M., Garovic, V. D., Grande, J. P., Arriaga, E. A., Kuipers, F., von Zglinicki, T., LeBrasseur, N. K., Campisi, J., Tchkonia, T. & Kirkland, J. L., Jun 1 2019, In : Aging Cell. 18, 3, e12950.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

The enigmatic role of growth hormone in age-related diseases, cognition, and longevity

Colon, G., Saccon, T., Schneider, A., Cavalcante, M. B., Huffman, D. M., Berryman, D., List, E., Ikeno, Y., Musi, N., Bartke, A., Kopchick, J., Kirkland, J. L., Tchkonia, T. & Masternak, M. M., Jan 1 2019, (Accepted/In press) In : GeroScience.

Research output: Contribution to journalReview article

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD + decline

Chini, C., Hogan, K. A., Warner, G. M., Tarragó, M. G., Peclat, T. R., Tchkonia, T., Kirkland, J. L. & Chini, E. N., May 28 2019, In : Biochemical and Biophysical Research Communications. 513, 2, p. 486-493 8 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Therapeutic Approaches to Aging - Reply

Tchkonia, T. & Kirkland, J. L., Mar 5 2019, In : JAMA - Journal of the American Medical Association. 321, 9, p. 901-902 2 p.

Research output: Contribution to journalLetter

2 Scopus citations
2018

Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies

Tchkonia, T. & Kirkland, J. L., Jan 1 2018, (Accepted/In press) In : JAMA - Journal of the American Medical Association.

Research output: Contribution to journalArticle

39 Scopus citations

Cellular Senescence Biomarker p16 INK4a + Cell Burden in Thigh Adipose is Associated with Poor Physical Function in Older Women

Justice, J. N., Gregory, H., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Kritchevsky, S. B. & Nicklas, B. J., Jun 14 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 7, p. 939-945 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L. & 2 others, Robbins, P. D. & Niedernhofer, L. J., Oct 1 2018, In : EBioMedicine. 36, p. 18-28 11 p.

Research output: Contribution to journalArticle

55 Scopus citations
26 Scopus citations

Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging

Rocca, W. A., Gazzuola Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., LeBrasseur, N. K., Schafer, M. J., Mielke, M. M., Kantarci, K. M., Stewart, E. A. & Miller, V. M., Nov 1 2018, In : Physiology (Bethesda, Md.). 33, 6, p. 374-383 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Premature physiologic aging as a paradigm for understanding increased risk of adverse health across the lifespan of survivors of childhood cancer

Ness, K. K., Kirkland, J. L., Monica Gramatges, M., Wang, Z., Kundu, M., McCastlain, K., Li-Harms, X., Zhang, J., Tchkonia, T., Francesca Pluijm, S. M. & Armstrong, G. T., Jul 20 2018, In : Journal of Clinical Oncology. 36, 21, p. 2206-2215 10 p.

Research output: Contribution to journalReview article

13 Scopus citations

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J., Weigand, B. M., Palmer, A. K., Weivoda, M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

220 Scopus citations

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice

Moncsek, A., Al-Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., Zhu, Y., Tchkonia, T., Kirkland, J. L., Gores, G. J., Müllhaupt, B., La Russo, N. F. & Mertens, J. C., Jan 1 2018, In : Hepatology. 67, 1, p. 247-259 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential

Nath, K. A., O'Brien, D. R., Croatt, A. J., Grande, J. P., Ackerman, A. W., Nath, M. C., Yamada, S., Terzic, A., Tchkonia, T., Kirkland, J. L. & Katusic, Z. S., Nov 1 2018, In : American journal of physiology. Renal physiology. 315, 5, p. F1493-F1499

Research output: Contribution to journalArticle

5 Scopus citations

Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model

Akkad, H., Cacciani, N., Llano-Diez, M., Corpeno Kalamgi, R., Tchkonia, T., Kirkland, J. L. & Larsson, L., Jan 1 2018, (Accepted/In press) In : Acta Physiologica.

Research output: Contribution to journalArticle

2 Scopus citations
2017

17α-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization

Stout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J. P. G., Zhu, Y., Hawse, J. R., Jurk, D., Palmer, A. K., Xu, M., Pirtskhalava, T., Evans, G. L., De Souza Santos, R., Frank, A. P., White, T. A., Monroe, D. G., Singh, R. J., Casaclang-Verzosa, G., Miller, J. D., Clegg, D. J., LeBrasseur, N. K. & 4 others, Von Zglinicki, T., Shulman, G. I., Tchkonia, T. & Kirkland, J. L., 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 1, p. 3-15 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Bilateral Oophorectomy and Accelerated Aging: Cause or Effect?

Rocca, W. A., Gazzuola Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., Stewart, E. A. & Miller, V. M., Sep 1 2017, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 72, 9, p. 1213-1217 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Biology of premature ageing in survivors of cancer

Cupit-Link, M. C., Kirkland, J. L., Ness, K. K., Armstrong, G. T., Tchkonia, T., LeBrasseur, N. K., Armenian, S. H., Ruddy, K. J. & Hashmi, S. K., Dec 1 2017, In : ESMO Open. 2, 5, e000250.

Research output: Contribution to journalReview article

27 Scopus citations

Cellular Senescence: A Translational Perspective

Kirkland, J. L. & Tchkonia, T., Mar 13 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

173 Scopus citations

Cellular senescence drives age-dependent hepatic steatosis

Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., Grellscheid, S. N., Hoeijmakers, J. H. J., Barnhoorn, S., Mann, D. A., Bird, T. G., Vermeij, W. P., Kirkland, J. L., Passos, J., Von Zglinicki, T. & Jurk, D., Jun 13 2017, In : Nature Communications. 8, 15691.

Research output: Contribution to journalArticle

148 Scopus citations

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature Communications. 8, 14532.

Research output: Contribution to journalArticle

251 Scopus citations

Corrigendum to: Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging (Journals of Gerontology - Series A Biological Sciences and Medical Sciences DOI: 10.1093/gerona/glx015)

Hadley, E. C., Kuchel, G. A., Newman, A. B., Allore, H. G., Bartley, J. M., Bergeman, C. S., Blinov, M. L., Colon-Emeric, C. S., Dabhar, F. S., Dugan, L. L., Dutta, C., Eldadah, B. A., Ferrucci, L., Kirkland, J. L., Kritchevsky, S. B., Lipsitz, L. A., Nadkarni, N. K., Reed, M. J., Schmader, K. E., Sierra, F. & 5 others, Studenski, S. A., Varadhan, R., Walston, J. D., Whitson, H. E. & Yung, R., Jul 1 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 7, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., Corbo, L., Tang, P., Bukata, C., Ring, N., Giacca, M., Li, X., Tchkonia, T., Kirkland, J. L., Niedernhofer, L. J. & Robbins, P. D., Dec 1 2017, In : Nature Communications. 8, 1, 422.

Research output: Contribution to journalArticle

106 Scopus citations
2 Scopus citations

New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T. & Kirkland, J. L., 2017, In : Aging. 9, 3, p. 1-9 9 p.

Research output: Contribution to journalArticle

103 Scopus citations

Physiological aging: Links among adipose tissue dysfunction, diabetes, and frailty

Stout, M. B., Justice, J. N., Nicklas, B. J. & Kirkland, J. L., Jan 1 2017, In : Physiology. 32, 1, p. 9-19 11 p.

Research output: Contribution to journalReview article

48 Scopus citations

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

169 Scopus citations

The Clinical Potential of Senolytic Drugs

Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J. & Robbins, P. D., 2017, (Accepted/In press) In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

116 Scopus citations

TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

Kandhaya-Pillai, R., Miro-Mur, F., Alijotas-Reig, J., Tchkonia, T., Kirkland, J. L. & Schwartz, S., Jan 1 2017, In : Aging. 9, 11, p. 2411-2435 25 p.

Research output: Contribution to journalArticle

16 Scopus citations

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

Xu, M., Bradley, E., Weivoda, M., Hwang, S. M., Pirtskhalava, T., Decklever, T., Curran, G. L., Ogrodnik, M., Jurk, D., Johnson, K. O., Lowe, V., Tchkonia, T., Westendorf, J. J. & Kirkland, J. L., Jun 1 2017, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 72, 6, p. 780-785 6 p.

Research output: Contribution to journalArticle

68 Scopus citations