• 11302 Citations
  • 55 Scopus h-Index
1973 …2021
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Research Output 1973 2019

2019
13 Citations (Scopus)

Aged-senescent cells contribute to impaired heart regeneration

Lewis-McDougall, F. C., Ruchaya, P. J., Domenjo-Vila, E., Shin Teoh, T., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., Tchkonia, T., Kirkland, J. L. & Ellison-Hughes, G. M., Jun 1 2019, In : Aging Cell. 18, 3, e12931.

Research output: Contribution to journalArticle

Open Access
Regeneration
Stem Cells
Cell Aging
Phenotype
Cyclin-Dependent Kinase Inhibitor p16
1 Citation (Scopus)

Cellular senescence: at the nexus between ageing and diabetes

Palmer, A. K., Gustafson, B., Kirkland, J. L. & Smith, U., Jan 1 2019, (Accepted/In press) In : Diabetologia.

Research output: Contribution to journalReview article

Cell Aging
Type 2 Diabetes Mellitus
Insulin Resistance
Obesity
Clinical Trials
1 Citation (Scopus)

Creating the Next Generation of Translational Geroscientists

Newman, J. C., Sokoloski, J. L., Robbins, P. D., Niedernhofer, L. J., Reed, M. J., Wei, J., Austad, S. N., Barzilai, N., Cohen, H. J., Kuchel, G. A., Kirkland, J. L. & Pignolo, R., Jan 1 2019, In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Open Access
Research Personnel
National Institute on Aging (U.S.)
Clinical Trials
Credentialing
Education
5 Citations (Scopus)

Hyperoxia-induced cellular senescence in fetal airway smooth muscle cells

Parikh, P., Britt, R. J., Manlove, L. J., Wicher, S. A., Roesler, A., Ravix, J., Teske, J., Thompson, M. A., Sieck, G. C., Kirkland, J. L., LeBrasseur, N. K., Tschumperlin, D. J., Pabelick, C. M. & Prakash, Y. S., Jan 1 2019, In : American journal of respiratory cell and molecular biology. 61, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Hyperoxia
Cell Aging
Smooth Muscle Myocytes
Muscle
Cells
2 Citations (Scopus)

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

Kim, S. R., Jiang, K., Ogrodnik, M., Chen, X., Zhu, X. Y., Lohmeier, H., Ahmed, L., Tang, H., Tchkonia, T., Hickson, L., Kirkland, J. L. & Lerman, L. O., Jan 1 2019, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Cell Aging
Quercetin
High Fat Diet
Nutrition
Fats
2 Citations (Scopus)

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

Farr, J. N., Rowsey, J. L., Eckhardt, B. A., Thicke, B. S., Fraser, D. G., Tchkonia, T., Kirkland, J. L., Monroe, D. G. & Khosla, S., Jan 1 2019, In : Journal of Bone and Mineral Research. 34, 8, p. 1407-1418 12 p.

Research output: Contribution to journalArticle

Cell Aging
Osteoporosis
Young Adult
Estrogens
Bone and Bones
19 Citations (Scopus)

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., Proctor, C., Correia-Melo, C., Victorelli, S., Fielder, E., Berlinguer-Palmini, R., Owens, A., Greaves, L. C., Kolsky, K. L., Parini, A., Douin-Echinard, V. & 14 others, LeBrasseur, N. K., Arthur, H. M., Tual-Chalot, S., Schafer, M. J., Roos, C. M., Miller, J. D., Robertson, N., Mann, J., Adams, P. D., Tchkonia, T., Kirkland, J. L., Mialet-Perez, J., Richardson, G. D. & Passos, J., Mar 1 2019, In : EMBO Journal. 38, 5, e100492.

Research output: Contribution to journalArticle

Open Access
Telomere
Cardiac Myocytes
Aging of materials
Telomere Shortening
Phenotype
3 Citations (Scopus)

Mixing old and young: Enhancing rejuvenation and accelerating aging

Lau, A., Kennedy, B. K., Kirkland, J. L. & Tullius, S. G., Jan 2 2019, In : Journal of Clinical Investigation. 129, 1, CI123946.

Research output: Contribution to journalReview article

Rejuvenation
Transplantation
Transplants
Age Factors
Hematopoietic Stem Cell Transplantation
5 Citations (Scopus)

Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series

Hurria, A., Carpenter, C. R., McFarland, F., Lundebjerg, N. E., de Cabo, R., Ferrucci, L., Studenski, S. A., Barzilai, N., Briggs, J. P., Ix, J. H., Kitzman, D. W., Kuchel, G. A., Musi, N., Newman, J. C., Rando, T. A., Smith, A. K., Walston, J. D., Kirkland, J. L. & Yung, R., Jan 1 2019, In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Organized Financing
Research
Geriatrics
National Institute on Aging (U.S.)
Chronic Disease
5 Citations (Scopus)

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., Podgorni, O., Enikolopov, G., Johnson, K. O., Xu, M., Inman, C., Palmer, A. K., Schafer, M., Weigl, M., Ikeno, Y., Burns, T. C. & 4 others, Passos, J., von Zglinicki, T., Kirkland, J. L. & Jurk, D., Jan 1 2019, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Manuscripts
Cell Aging
Neurogenesis
Publications
Anxiety
18 Citations (Scopus)

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., Podgorni, O., Enikolopov, G., Johnson, K. O., Xu, M., Inman, C., Palmer, A. K., Schafer, M., Weigl, M., Ikeno, Y., Burns, T. C. & 4 others, Passos, J., von Zglinicki, T., Kirkland, J. L. & Jurk, D., May 7 2019, In : Cell Metabolism. 29, 5, p. 1061-1077.e8

Research output: Contribution to journalArticle

Open Access
Cell Aging
Neurogenesis
Anxiety
Obesity
Obese Mice
4 Citations (Scopus)

Phases of Metabolic and Soft Tissue Changes in Months Preceding a Diagnosis of Pancreatic Ductal Adenocarcinoma

Sah, R. P., Sharma, A., Nagpal, S., Patlolla, S. H., Sharma, A., Kandlakunta, H., Anani, V., Angom, R. S., Kamboj, A. K., Ahmed, N., Mohapatra, S., Vivekanandhan, S., Philbrick, K. A., Weston, A., Takahashi, N. M., Kirkland, J. L., Javeed, N., Matveyenko, A. V., Levy, M. J., Mukhopadhyay, D. & 1 others, Chari, S. T., May 1 2019, In : Gastroenterology. 156, 6, p. 1742-1752 11 p.

Research output: Contribution to journalArticle

Subcutaneous Fat
Adenocarcinoma
Intra-Abdominal Fat
Hyperglycemia
Abdominal Subcutaneous Fat
26 Citations (Scopus)

Sarcopenia: Aging-related loss of muscle mass and function

Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L. & Sandri, M., Jan 1 2019, In : Physiological Reviews. 99, 1, p. 427-511 85 p.

Research output: Contribution to journalArticle

Sarcopenia
Muscles
Motor Neurons
Muscle Proteins
Cost Savings
2 Citations (Scopus)

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

Prata, L. G. P. L., Ovsyannikova, I. G., Tchkonia, T. & Kirkland, J. L., Jan 1 2019, In : Seminars in immunology.

Research output: Contribution to journalReview article

Immune System
Therapeutics
Phenotype
Immunologic Factors
Adaptive Immunity

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
Quercetin
Diabetic Nephropathies
Clinical Trials
Macrophages
Tissue
53 Citations (Scopus)

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N. & Kirkland, J. L., Jan 1 2019, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Quercetin
Labels
Cell Aging
Phenotype

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Suvakov, S., Cubro, H., White, W. M., Butler Tobah, Y. S., Weissgerber, T. L., Jordan, K. L., Zhu, X. Y., Woollard, J. R., Chebib, F., Milic, N. M., Grande, J. P., Xu, M., Tchkonia, T., Kirkland, J. L., Lerman, L. O. & Garovic, V. D., Sep 14 2019, In : Biology of Sex Differences. 10, 1, 49.

Research output: Contribution to journalArticle

Open Access
Pre-Eclampsia
Mesenchymal Stromal Cells
pregnancy
proliferation
migration
12 Citations (Scopus)

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang-Verzosa, G., Johnson, K. O., Cubro, H., Doornebal, E. J., Ogrodnik, M., Jurk, D., Jensen, M. D., Chini, E. N., Miller, J. D., Matveyenko, A. V., Stout, M. B. & 13 others, Schafer, M. J., White, T. A., Hickson, L., Demaria, M., Garovic, V. D., Grande, J. P., Arriaga, E. A., Kuipers, F., von Zglinicki, T., LeBrasseur, N. K., Campisi, J., Tchkonia, T. & Kirkland, J. L., Jun 1 2019, In : Aging Cell. 18, 3, e12950.

Research output: Contribution to journalArticle

Open Access
Obesity
Adipose Tissue
Obese Mice
Insulin Resistance
p16 Genes

The enigmatic role of growth hormone in age-related diseases, cognition, and longevity

Colon, G., Saccon, T., Schneider, A., Cavalcante, M. B., Huffman, D. M., Berryman, D., List, E., Ikeno, Y., Musi, N., Bartke, A., Kopchick, J., Kirkland, J. L., Tchkonia, T. & Masternak, M. M., Jan 1 2019, (Accepted/In press) In : GeroScience.

Research output: Contribution to journalReview article

Cognition
Growth Hormone
Anterior Pituitary Gland
Disease Resistance
Adiposity
6 Citations (Scopus)

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD + decline

Chini, C., Hogan, K. A., Warner, G. M., Tarragó, M. G., Peclat, T. R., Tchkonia, T., Kirkland, J. L. & Chini, E. N., May 28 2019, In : Biochemical and Biophysical Research Communications. 513, 2, p. 486-493 8 p.

Research output: Contribution to journalArticle

Open Access
NAD+ Nucleosidase
NAD
Cell Aging
Aging of materials
Phenotype
1 Citation (Scopus)

Therapeutic Approaches to Aging - Reply

Tchkonia, T. & Kirkland, J. L., Mar 5 2019, In : JAMA - Journal of the American Medical Association. 321, 9, p. 901-902 2 p.

Research output: Contribution to journalLetter

Therapeutics
2018
29 Citations (Scopus)

Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies

Tchkonia, T. & Kirkland, J. L., Jan 1 2018, (Accepted/In press) In : JAMA - Journal of the American Medical Association.

Research output: Contribution to journalArticle

Cell Aging
Chronic Disease
Comorbidity
Vaccines
Clinical Trials
14 Citations (Scopus)

Cellular Senescence Biomarker p16 INK4a + Cell Burden in Thigh Adipose is Associated with Poor Physical Function in Older Women

Justice, J. N., Gregory, H., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Kritchevsky, S. B. & Nicklas, B. J., Jun 14 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 7, p. 939-945 7 p.

Research output: Contribution to journalArticle

Cell Aging
Thigh
Biomarkers
Caloric Restriction
Resistance Training
40 Citations (Scopus)

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L. & 2 others, Robbins, P. D. & Niedernhofer, L. J., Oct 1 2018, In : EBioMedicine. 36, p. 18-28 11 p.

Research output: Contribution to journalArticle

Flavonoids
Health
Tissue
Aging of materials
Adipose Tissue
19 Citations (Scopus)
Cell Aging
Osteoporosis
Bone
Aging of materials
Bone and Bones
6 Citations (Scopus)

Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging

Rocca, W. A., Gazzuola Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., LeBrasseur, N. K., Schafer, M. J., Mielke, M. M., Kantarci, K. M., Stewart, E. A. & Miller, V. M., Nov 1 2018, In : Physiology (Bethesda, Md.). 33, 6, p. 374-383 10 p.

Research output: Contribution to journalArticle

Ovariectomy
Hormones
Comorbidity
Estrogens
Survival
8 Citations (Scopus)

Premature physiologic aging as a paradigm for understanding increased risk of adverse health across the lifespan of survivors of childhood cancer

Ness, K. K., Kirkland, J. L., Monica Gramatges, M., Wang, Z., Kundu, M., McCastlain, K., Li-Harms, X., Zhang, J., Tchkonia, T., Francesca Pluijm, S. M. & Armstrong, G. T., Jul 20 2018, In : Journal of Clinical Oncology. 36, 21, p. 2206-2215 10 p.

Research output: Contribution to journalReview article

Premature Aging
Survivors
Health
Neoplasms
Research
162 Citations (Scopus)

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J., Weigand, B. M., Palmer, A. K., Weivoda, M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

Health
Tissue
Cell Aging
Quercetin
Pathology
22 Citations (Scopus)

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice

Moncsek, A., Al-Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., Zhu, Y., Tchkonia, T., Kirkland, J. L., Gores, G. J., Müllhaupt, B., La Russo, N. F. & Mertens, J. C., Jan 1 2018, In : Hepatology. 67, 1, p. 247-259 13 p.

Research output: Contribution to journalArticle

MDR Genes
Gene Knockout Techniques
B-Cell Lymphoma
Knockout Mice
Fibrosis
3 Citations (Scopus)

The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential

Nath, K. A., O'Brien, D. R., Croatt, A. J., Grande, J. P., Ackerman, A. W., Nath, M. C., Yamada, S., Terzic, A., Tchkonia, T., Kirkland, J. L. & Katusic, Z. S., Nov 1 2018, In : American journal of physiology. Renal physiology. 315, 5, p. F1493-F1499

Research output: Contribution to journalArticle

Arteriovenous Fistula
Fistula
Chronic Renal Insufficiency
Dialysis
Phenotype
2 Citations (Scopus)

Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model

Akkad, H., Cacciani, N., Llano-Diez, M., Corpeno Kalamgi, R., Tchkonia, T., Kirkland, J. L. & Larsson, L., Jan 1 2018, (Accepted/In press) In : Acta Physiologica.

Research output: Contribution to journalArticle

Muscular Diseases
Critical Illness
Glucocorticoids
Skeletal Muscle
Intensive Care Units
2017
26 Citations (Scopus)

17α-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization

Stout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J. P. G., Zhu, Y., Hawse, J. R., Jurk, D., Palmer, A. K., Xu, M., Pirtskhalava, T., Evans, G. L., De Souza Santos, R., Frank, A. P., White, T. A., Monroe, D. G., Singh, R. J., Casaclang-Verzosa, G., Miller, J. D., Clegg, D. J., LeBrasseur, N. K. & 4 others, Von Zglinicki, T., Shulman, G. I., Tchkonia, T. & Kirkland, J. L., 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 1, p. 3-15 13 p.

Research output: Contribution to journalArticle

Feminization
Intra-Abdominal Fat
Estradiol
Adiposity
Glucose
21 Citations (Scopus)

Bilateral Oophorectomy and Accelerated Aging: Cause or Effect?

Rocca, W. A., Gazzuola Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., Stewart, E. A. & Miller, V. M., Sep 1 2017, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 72, 9, p. 1213-1217 5 p.

Research output: Contribution to journalArticle

Ovariectomy
Comorbidity
Epidemiology
Body Mass Index
Cohort Studies
21 Citations (Scopus)

Biology of premature ageing in survivors of cancer

Cupit-Link, M. C., Kirkland, J. L., Ness, K. K., Armstrong, G. T., Tchkonia, T., LeBrasseur, N. K., Armenian, S. H., Ruddy, K. J. & Hashmi, S. K., Dec 1 2017, In : ESMO Open. 2, 5, e000250.

Research output: Contribution to journalReview article

Premature Aging
Survivors
Neoplasms
Comorbidity
Biological Phenomena
148 Citations (Scopus)

Cellular Senescence: A Translational Perspective

Kirkland, J. L. & Tchkonia, T., Mar 13 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Cell Aging
Aging of materials
Geriatrics
Tissue
Phenotype
126 Citations (Scopus)

Cellular senescence drives age-dependent hepatic steatosis

Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., Grellscheid, S. N., Hoeijmakers, J. H. J., Barnhoorn, S., Mann, D. A., Bird, T. G., Vermeij, W. P., Kirkland, J. L., Passos, J., Von Zglinicki, T. & Jurk, D., Jun 13 2017, In : Nature Communications. 8, 15691.

Research output: Contribution to journalArticle

Cell Aging
Fats
Liver
fats
Hepatocytes
214 Citations (Scopus)

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature Communications. 8, 14532.

Research output: Contribution to journalArticle

fibrosis
Pulmonary diseases
Cell Aging
Idiopathic Pulmonary Fibrosis
Lung Diseases
1 Citation (Scopus)

Corrigendum to: Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging (Journals of Gerontology - Series A Biological Sciences and Medical Sciences DOI: 10.1093/gerona/glx015)

Hadley, E. C., Kuchel, G. A., Newman, A. B., Allore, H. G., Bartley, J. M., Bergeman, C. S., Blinov, M. L., Colon-Emeric, C. S., Dabhar, F. S., Dugan, L. L., Dutta, C., Eldadah, B. A., Ferrucci, L., Kirkland, J. L., Kritchevsky, S. B., Lipsitz, L. A., Nadkarni, N. K., Reed, M. J., Schmader, K. E., Sierra, F. & 5 others, Studenski, S. A., Varadhan, R., Walston, J. D., Whitson, H. E. & Yung, R., Jul 1 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 7, 1 p.

Research output: Contribution to journalComment/debate

Biological Science Disciplines
Geriatrics
Education
corrigendum
92 Citations (Scopus)

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., Corbo, L., Tang, P., Bukata, C., Ring, N., Giacca, M., Li, X., Tchkonia, T., Kirkland, J. L., Niedernhofer, L. J. & Robbins, P. D., Dec 1 2017, In : Nature Communications. 8, 1, 422.

Research output: Contribution to journalArticle

inhibitors
drugs
Aging of materials
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
mice
1 Citation (Scopus)
Janus Kinase 2
STAT3 Transcription Factor
Artificial Respiration
Immobilization
Intensive Care Units
81 Citations (Scopus)

New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T. & Kirkland, J. L., 2017, In : Aging. 9, 3, p. 1-9 9 p.

Research output: Contribution to journalArticle

flavone
Human Umbilical Vein Endothelial Cells
Apoptosis
Quercetin
fisetin
42 Citations (Scopus)

Physiological aging: Links among adipose tissue dysfunction, diabetes, and frailty

Stout, M. B., Justice, J. N., Nicklas, B. J. & Kirkland, J. L., Jan 1 2017, In : Physiology. 32, 1, p. 9-19 11 p.

Research output: Contribution to journalReview article

Adipose Tissue
Chronic Disease
Subcutaneous Fat
Chemokines
Insulin Resistance
135 Citations (Scopus)

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

Cell Aging
Osteoporosis
Bone
Bone and Bones
Caspase 8
96 Citations (Scopus)

The Clinical Potential of Senolytic Drugs

Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J. & Robbins, P. D., 2017, (Accepted/In press) In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Clinical Trials
Geriatrics
Vascular Calcification
Intervertebral Disc Degeneration
11 Citations (Scopus)

TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

Kandhaya-Pillai, R., Miro-Mur, F., Alijotas-Reig, J., Tchkonia, T., Kirkland, J. L. & Schwartz, S., Jan 1 2017, In : Aging. 9, 11, p. 2411-2435 25 p.

Research output: Contribution to journalArticle

Interferons
DNA Damage
Tumor Necrosis Factor-alpha
Cytokines
Cell Aging
59 Citations (Scopus)

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

Xu, M., Bradley, E., Weivoda, M., Hwang, S. M., Pirtskhalava, T., Decklever, T., Curran, G. L., Ogrodnik, M., Jurk, D., Johnson, K. O., Lowe, V., Tchkonia, T., Westendorf, J. J. & Kirkland, J. L., Jun 1 2017, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 72, 6, p. 780-785 6 p.

Research output: Contribution to journalArticle

Osteoarthritis
Ear Cartilage
Pain
Cell Aging
Cell Transplantation
2016
46 Citations (Scopus)

Accelerated Accumulation of Multimorbidity After Bilateral Oophorectomy: A Population-Based Cohort Study

Rocca, W. A., Gazzuola-Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., Stewart, E. A. & Miller, V. M., Nov 1 2016, In : Mayo Clinic Proceedings. 91, 11, p. 1577-1589 13 p.

Research output: Contribution to journalArticle

Ovariectomy
Comorbidity
Cohort Studies
Population
Estrogens
76 Citations (Scopus)

Aging and adipose tissue: Potential interventions for diabetes and regenerative medicine

Palmer, A. K. & Kirkland, J. L., Jan 5 2016, (Accepted/In press) In : Experimental Gerontology.

Research output: Contribution to journalArticle

Regenerative Medicine
Medical problems
Adipose Tissue
Aging of materials
Tissue
9 Citations (Scopus)

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms

Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N. & Kirkland, J. L., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1388-1394 7 p.

Research output: Contribution to journalArticle

Research
Research Personnel
Pharmaceutical Preparations
Drug Discovery
Therapeutics
159 Citations (Scopus)

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Roos, C. M., Zhang, B., Palmer, A. K., Ogrodnik, M. B., Pirtskhalava, T., Thalji, N. M., Hagler, M., Jurk, D., Smith, L. A., Casaclang-Verzosa, G., Zhu, Y., Schafer, M. J., Tchkonia, T., Kirkland, J. L. & Miller, J. D., Oct 1 2016, In : Aging Cell. 15, 5, p. 973-977 5 p.

Research output: Contribution to journalArticle

Tunica Intima
Therapeutics
Vascular Stiffness
Quercetin
Atherosclerotic Plaques