• 11262 Citations
  • 55 Scopus h-Index
1973 …2021
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Research Output 1973 2019

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Article
2019
13 Citations (Scopus)

Aged-senescent cells contribute to impaired heart regeneration

Lewis-McDougall, F. C., Ruchaya, P. J., Domenjo-Vila, E., Shin Teoh, T., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., Tchkonia, T., Kirkland, J. L. & Ellison-Hughes, G. M., Jun 1 2019, In : Aging Cell. 18, 3, e12931.

Research output: Contribution to journalArticle

Open Access
Regeneration
Stem Cells
Cell Aging
Phenotype
Cyclin-Dependent Kinase Inhibitor p16
1 Citation (Scopus)

Creating the Next Generation of Translational Geroscientists

Newman, J. C., Sokoloski, J. L., Robbins, P. D., Niedernhofer, L. J., Reed, M. J., Wei, J., Austad, S. N., Barzilai, N., Cohen, H. J., Kuchel, G. A., Kirkland, J. L. & Pignolo, R., Jan 1 2019, In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Open Access
Research Personnel
National Institute on Aging (U.S.)
Clinical Trials
Credentialing
Education
5 Citations (Scopus)

Hyperoxia-induced cellular senescence in fetal airway smooth muscle cells

Parikh, P., Britt, R. J., Manlove, L. J., Wicher, S. A., Roesler, A., Ravix, J., Teske, J., Thompson, M. A., Sieck, G. C., Kirkland, J. L., LeBrasseur, N. K., Tschumperlin, D. J., Pabelick, C. M. & Prakash, Y. S., Jan 1 2019, In : American journal of respiratory cell and molecular biology. 61, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Hyperoxia
Cell Aging
Smooth Muscle Myocytes
Muscle
Cells
2 Citations (Scopus)

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

Kim, S. R., Jiang, K., Ogrodnik, M., Chen, X., Zhu, X. Y., Lohmeier, H., Ahmed, L., Tang, H., Tchkonia, T., Hickson, L., Kirkland, J. L. & Lerman, L. O., Jan 1 2019, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Cell Aging
Quercetin
High Fat Diet
Nutrition
Fats
1 Citation (Scopus)

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

Farr, J. N., Rowsey, J. L., Eckhardt, B. A., Thicke, B. S., Fraser, D. G., Tchkonia, T., Kirkland, J. L., Monroe, D. G. & Khosla, S., Jan 1 2019, In : Journal of Bone and Mineral Research. 34, 8, p. 1407-1418 12 p.

Research output: Contribution to journalArticle

Cell Aging
Osteoporosis
Young Adult
Estrogens
Bone and Bones
19 Citations (Scopus)

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., Proctor, C., Correia-Melo, C., Victorelli, S., Fielder, E., Berlinguer-Palmini, R., Owens, A., Greaves, L. C., Kolsky, K. L., Parini, A., Douin-Echinard, V. & 14 others, LeBrasseur, N. K., Arthur, H. M., Tual-Chalot, S., Schafer, M. J., Roos, C. M., Miller, J. D., Robertson, N., Mann, J., Adams, P. D., Tchkonia, T., Kirkland, J. L., Mialet-Perez, J., Richardson, G. D. & Passos, J., Mar 1 2019, In : EMBO Journal. 38, 5, e100492.

Research output: Contribution to journalArticle

Open Access
Telomere
Cardiac Myocytes
Aging of materials
Telomere Shortening
Phenotype
5 Citations (Scopus)

Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series

Hurria, A., Carpenter, C. R., McFarland, F., Lundebjerg, N. E., de Cabo, R., Ferrucci, L., Studenski, S. A., Barzilai, N., Briggs, J. P., Ix, J. H., Kitzman, D. W., Kuchel, G. A., Musi, N., Newman, J. C., Rando, T. A., Smith, A. K., Walston, J. D., Kirkland, J. L. & Yung, R., Jan 1 2019, In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Organized Financing
Research
Geriatrics
National Institute on Aging (U.S.)
Chronic Disease
4 Citations (Scopus)

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., Podgorni, O., Enikolopov, G., Johnson, K. O., Xu, M., Inman, C., Palmer, A. K., Schafer, M., Weigl, M., Ikeno, Y., Burns, T. C. & 4 others, Passos, J., von Zglinicki, T., Kirkland, J. L. & Jurk, D., Jan 1 2019, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Manuscripts
Cell Aging
Neurogenesis
Publications
Anxiety
18 Citations (Scopus)

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., Podgorni, O., Enikolopov, G., Johnson, K. O., Xu, M., Inman, C., Palmer, A. K., Schafer, M., Weigl, M., Ikeno, Y., Burns, T. C. & 4 others, Passos, J., von Zglinicki, T., Kirkland, J. L. & Jurk, D., May 7 2019, In : Cell Metabolism. 29, 5, p. 1061-1077.e8

Research output: Contribution to journalArticle

Open Access
Cell Aging
Neurogenesis
Anxiety
Obesity
Obese Mice
4 Citations (Scopus)

Phases of Metabolic and Soft Tissue Changes in Months Preceding a Diagnosis of Pancreatic Ductal Adenocarcinoma

Sah, R. P., Sharma, A., Nagpal, S., Patlolla, S. H., Sharma, A., Kandlakunta, H., Anani, V., Angom, R. S., Kamboj, A. K., Ahmed, N., Mohapatra, S., Vivekanandhan, S., Philbrick, K. A., Weston, A., Takahashi, N. M., Kirkland, J. L., Javeed, N., Matveyenko, A. V., Levy, M. J., Mukhopadhyay, D. & 1 others, Chari, S. T., May 1 2019, In : Gastroenterology. 156, 6, p. 1742-1752 11 p.

Research output: Contribution to journalArticle

Subcutaneous Fat
Adenocarcinoma
Intra-Abdominal Fat
Hyperglycemia
Abdominal Subcutaneous Fat
26 Citations (Scopus)

Sarcopenia: Aging-related loss of muscle mass and function

Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L. & Sandri, M., Jan 1 2019, In : Physiological Reviews. 99, 1, p. 427-511 85 p.

Research output: Contribution to journalArticle

Sarcopenia
Muscles
Motor Neurons
Muscle Proteins
Cost Savings

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
Quercetin
Diabetic Nephropathies
Clinical Trials
Macrophages
Tissue
53 Citations (Scopus)

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N. & Kirkland, J. L., Jan 1 2019, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Quercetin
Labels
Cell Aging
Phenotype

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Suvakov, S., Cubro, H., White, W. M., Butler Tobah, Y. S., Weissgerber, T. L., Jordan, K. L., Zhu, X. Y., Woollard, J. R., Chebib, F., Milic, N. M., Grande, J. P., Xu, M., Tchkonia, T., Kirkland, J. L., Lerman, L. O. & Garovic, V. D., Sep 14 2019, In : Biology of Sex Differences. 10, 1, 49.

Research output: Contribution to journalArticle

Open Access
Pre-Eclampsia
Mesenchymal Stromal Cells
pregnancy
proliferation
migration
12 Citations (Scopus)

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang-Verzosa, G., Johnson, K. O., Cubro, H., Doornebal, E. J., Ogrodnik, M., Jurk, D., Jensen, M. D., Chini, E. N., Miller, J. D., Matveyenko, A. V., Stout, M. B. & 13 others, Schafer, M. J., White, T. A., Hickson, L., Demaria, M., Garovic, V. D., Grande, J. P., Arriaga, E. A., Kuipers, F., von Zglinicki, T., LeBrasseur, N. K., Campisi, J., Tchkonia, T. & Kirkland, J. L., Jun 1 2019, In : Aging Cell. 18, 3, e12950.

Research output: Contribution to journalArticle

Open Access
Obesity
Adipose Tissue
Obese Mice
Insulin Resistance
p16 Genes
6 Citations (Scopus)

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD + decline

Chini, C., Hogan, K. A., Warner, G. M., Tarragó, M. G., Peclat, T. R., Tchkonia, T., Kirkland, J. L. & Chini, E. N., May 28 2019, In : Biochemical and Biophysical Research Communications. 513, 2, p. 486-493 8 p.

Research output: Contribution to journalArticle

Open Access
NAD+ Nucleosidase
NAD
Cell Aging
Aging of materials
Phenotype
2018
29 Citations (Scopus)

Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies

Tchkonia, T. & Kirkland, J. L., Jan 1 2018, (Accepted/In press) In : JAMA - Journal of the American Medical Association.

Research output: Contribution to journalArticle

Cell Aging
Chronic Disease
Comorbidity
Vaccines
Clinical Trials
14 Citations (Scopus)

Cellular Senescence Biomarker p16 INK4a + Cell Burden in Thigh Adipose is Associated with Poor Physical Function in Older Women

Justice, J. N., Gregory, H., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Kritchevsky, S. B. & Nicklas, B. J., Jun 14 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 7, p. 939-945 7 p.

Research output: Contribution to journalArticle

Cell Aging
Thigh
Biomarkers
Caloric Restriction
Resistance Training
38 Citations (Scopus)

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L. & 2 others, Robbins, P. D. & Niedernhofer, L. J., Oct 1 2018, In : EBioMedicine. 36, p. 18-28 11 p.

Research output: Contribution to journalArticle

Flavonoids
Health
Tissue
Aging of materials
Adipose Tissue
19 Citations (Scopus)
Cell Aging
Osteoporosis
Bone
Aging of materials
Bone and Bones
6 Citations (Scopus)

Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging

Rocca, W. A., Gazzuola Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., LeBrasseur, N. K., Schafer, M. J., Mielke, M. M., Kantarci, K. M., Stewart, E. A. & Miller, V. M., Nov 1 2018, In : Physiology (Bethesda, Md.). 33, 6, p. 374-383 10 p.

Research output: Contribution to journalArticle

Ovariectomy
Hormones
Comorbidity
Estrogens
Survival
160 Citations (Scopus)

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J., Weigand, B. M., Palmer, A. K., Weivoda, M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

Health
Tissue
Cell Aging
Quercetin
Pathology
22 Citations (Scopus)

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice

Moncsek, A., Al-Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., Zhu, Y., Tchkonia, T., Kirkland, J. L., Gores, G. J., Müllhaupt, B., La Russo, N. F. & Mertens, J. C., Jan 1 2018, In : Hepatology. 67, 1, p. 247-259 13 p.

Research output: Contribution to journalArticle

MDR Genes
Gene Knockout Techniques
B-Cell Lymphoma
Knockout Mice
Fibrosis
3 Citations (Scopus)

The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential

Nath, K. A., O'Brien, D. R., Croatt, A. J., Grande, J. P., Ackerman, A. W., Nath, M. C., Yamada, S., Terzic, A., Tchkonia, T., Kirkland, J. L. & Katusic, Z. S., Nov 1 2018, In : American journal of physiology. Renal physiology. 315, 5, p. F1493-F1499

Research output: Contribution to journalArticle

Arteriovenous Fistula
Fistula
Chronic Renal Insufficiency
Dialysis
Phenotype
2 Citations (Scopus)

Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model

Akkad, H., Cacciani, N., Llano-Diez, M., Corpeno Kalamgi, R., Tchkonia, T., Kirkland, J. L. & Larsson, L., Jan 1 2018, (Accepted/In press) In : Acta Physiologica.

Research output: Contribution to journalArticle

Muscular Diseases
Critical Illness
Glucocorticoids
Skeletal Muscle
Intensive Care Units
2017
26 Citations (Scopus)

17α-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization

Stout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J. P. G., Zhu, Y., Hawse, J. R., Jurk, D., Palmer, A. K., Xu, M., Pirtskhalava, T., Evans, G. L., De Souza Santos, R., Frank, A. P., White, T. A., Monroe, D. G., Singh, R. J., Casaclang-Verzosa, G., Miller, J. D., Clegg, D. J., LeBrasseur, N. K. & 4 others, Von Zglinicki, T., Shulman, G. I., Tchkonia, T. & Kirkland, J. L., 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 1, p. 3-15 13 p.

Research output: Contribution to journalArticle

Feminization
Intra-Abdominal Fat
Estradiol
Adiposity
Glucose
21 Citations (Scopus)

Bilateral Oophorectomy and Accelerated Aging: Cause or Effect?

Rocca, W. A., Gazzuola Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., Stewart, E. A. & Miller, V. M., Sep 1 2017, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 72, 9, p. 1213-1217 5 p.

Research output: Contribution to journalArticle

Ovariectomy
Comorbidity
Epidemiology
Body Mass Index
Cohort Studies
143 Citations (Scopus)

Cellular Senescence: A Translational Perspective

Kirkland, J. L. & Tchkonia, T., Mar 13 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Cell Aging
Aging of materials
Geriatrics
Tissue
Phenotype
126 Citations (Scopus)

Cellular senescence drives age-dependent hepatic steatosis

Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., Grellscheid, S. N., Hoeijmakers, J. H. J., Barnhoorn, S., Mann, D. A., Bird, T. G., Vermeij, W. P., Kirkland, J. L., Passos, J., Von Zglinicki, T. & Jurk, D., Jun 13 2017, In : Nature Communications. 8, 15691.

Research output: Contribution to journalArticle

Cell Aging
Fats
Liver
fats
Hepatocytes
213 Citations (Scopus)

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature Communications. 8, 14532.

Research output: Contribution to journalArticle

fibrosis
Pulmonary diseases
Cell Aging
Idiopathic Pulmonary Fibrosis
Lung Diseases
92 Citations (Scopus)

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., Corbo, L., Tang, P., Bukata, C., Ring, N., Giacca, M., Li, X., Tchkonia, T., Kirkland, J. L., Niedernhofer, L. J. & Robbins, P. D., Dec 1 2017, In : Nature Communications. 8, 1, 422.

Research output: Contribution to journalArticle

inhibitors
drugs
Aging of materials
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
mice
1 Citation (Scopus)
Janus Kinase 2
STAT3 Transcription Factor
Artificial Respiration
Immobilization
Intensive Care Units
81 Citations (Scopus)

New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T. & Kirkland, J. L., 2017, In : Aging. 9, 3, p. 1-9 9 p.

Research output: Contribution to journalArticle

flavone
Human Umbilical Vein Endothelial Cells
Apoptosis
Quercetin
fisetin
133 Citations (Scopus)

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

Cell Aging
Osteoporosis
Bone
Bone and Bones
Caspase 8
95 Citations (Scopus)

The Clinical Potential of Senolytic Drugs

Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J. & Robbins, P. D., 2017, (Accepted/In press) In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Clinical Trials
Geriatrics
Vascular Calcification
Intervertebral Disc Degeneration
11 Citations (Scopus)

TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

Kandhaya-Pillai, R., Miro-Mur, F., Alijotas-Reig, J., Tchkonia, T., Kirkland, J. L. & Schwartz, S., Jan 1 2017, In : Aging. 9, 11, p. 2411-2435 25 p.

Research output: Contribution to journalArticle

Interferons
DNA Damage
Tumor Necrosis Factor-alpha
Cytokines
Cell Aging
58 Citations (Scopus)

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

Xu, M., Bradley, E., Weivoda, M., Hwang, S. M., Pirtskhalava, T., Decklever, T., Curran, G. L., Ogrodnik, M., Jurk, D., Johnson, K. O., Lowe, V., Tchkonia, T., Westendorf, J. J. & Kirkland, J. L., Jun 1 2017, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 72, 6, p. 780-785 6 p.

Research output: Contribution to journalArticle

Osteoarthritis
Ear Cartilage
Pain
Cell Aging
Cell Transplantation
2016
46 Citations (Scopus)

Accelerated Accumulation of Multimorbidity After Bilateral Oophorectomy: A Population-Based Cohort Study

Rocca, W. A., Gazzuola-Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., Stewart, E. A. & Miller, V. M., Nov 1 2016, In : Mayo Clinic Proceedings. 91, 11, p. 1577-1589 13 p.

Research output: Contribution to journalArticle

Ovariectomy
Comorbidity
Cohort Studies
Population
Estrogens
75 Citations (Scopus)

Aging and adipose tissue: Potential interventions for diabetes and regenerative medicine

Palmer, A. K. & Kirkland, J. L., Jan 5 2016, (Accepted/In press) In : Experimental Gerontology.

Research output: Contribution to journalArticle

Regenerative Medicine
Medical problems
Adipose Tissue
Aging of materials
Tissue
9 Citations (Scopus)

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms

Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N. & Kirkland, J. L., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1388-1394 7 p.

Research output: Contribution to journalArticle

Research
Research Personnel
Pharmaceutical Preparations
Drug Discovery
Therapeutics
159 Citations (Scopus)

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Roos, C. M., Zhang, B., Palmer, A. K., Ogrodnik, M. B., Pirtskhalava, T., Thalji, N. M., Hagler, M., Jurk, D., Smith, L. A., Casaclang-Verzosa, G., Zhu, Y., Schafer, M. J., Tchkonia, T., Kirkland, J. L. & Miller, J. D., Oct 1 2016, In : Aging Cell. 15, 5, p. 973-977 5 p.

Research output: Contribution to journalArticle

Tunica Intima
Therapeutics
Vascular Stiffness
Quercetin
Atherosclerotic Plaques
14 Citations (Scopus)

Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience

Huffman, D. M., Justice, J. N., Stout, M. B., Kirkland, J. L., Barzilai, N. & Austad, S. N., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1395-1406 12 p.

Research output: Contribution to journalArticle

Guidelines
Health
Life Expectancy
Body Composition
Age of Onset
61 Citations (Scopus)

Exercise prevents diet-induced cellular senescence in adipose tissue

Schafer, M. J., White, T. A., Evans, G., Tonne, J. M., Verzosa, G. C., Stout, M. B., Mazula, D. L., Palmer, A. K., Baker, D. J., Jensen, M. D., Torbenson, M., Miller, J. D., Ikeda, Y. H., Tchkonia, T., Van Deursen, J., Kirkland, J. L. & LeBrasseur, N. K., Jun 1 2016, In : Diabetes. 65, 6, p. 1606-1615 10 p.

Research output: Contribution to journalArticle

Cell Aging
Fast Foods
Adipose Tissue
Diet
Intra-Abdominal Fat
24 Citations (Scopus)

Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes

Justice, J., Miller, J. D., Newman, J. C., Hashmi, S. K., Halter, J., Austad, S. N., Barzilai, N. & Kirkland, J. L., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1415-1423 9 p.

Research output: Contribution to journalArticle

Clinical Trials
Therapeutics
Geriatrics
Chronic Disease
Health
8 Citations (Scopus)

Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence

Comisford, R., Lubbers, E. R., Householder, L. A., Suer, O., Tchkonia, T., Kirkland, J. L., List, E. O., Kopchick, J. J. & Berryman, D. E., Feb 1 2016, In : Gerontology. 62, 2, p. 163-172 10 p.

Research output: Contribution to journalArticle

Somatotropin Receptors
Hormone Antagonists
White Adipose Tissue
Cell Aging
Subcutaneous Fat
21 Citations (Scopus)

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

Carpio, L. R., Bradley, E., McGee-Lawrence, M. E., Weivoda, M., Poston, D. D., Dudakovic, A., Xu, M., Tchkonia, T., Kirkland, J. L., van Wijnen, A. J., Oursler, M. J. & Westendorf, J. J., Aug 9 2016, In : Science Signaling. 9, 440, ra79.

Research output: Contribution to journalArticle

Chondrocytes
Janus Kinases
Osteogenesis
Bone
Genes
165 Citations (Scopus)

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann-Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., Wren, J. D., Niedernhofer, L. J., Robbins, P. D. & Kirkland, J. L., 2016, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Umbilical Veins
Epithelial Cells
Quercetin
Computational Biology
Fibroblasts
67 Citations (Scopus)

Identification of Senescent Cells in the Bone Microenvironment

Farr, J., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M., Drake, M. M., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Bonewald, L. F., Pignolo, R., Monroe, D. G. & Khosla, S., Nov 1 2016, In : Journal of Bone and Mineral Research. 31, 11, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

Osteocytes
Bone and Bones
Phenotype
Satellite DNA
Cell Aging
19 Citations (Scopus)

Molecular pathology endpoints useful for aging studies

Niedernhofer, L. J., Kirkland, J. L. & Ladiges, W., Apr 19 2016, (Accepted/In press) In : Ageing Research Reviews.

Research output: Contribution to journalArticle

Molecular Pathology
Metformin
Pathology
Aging of materials
Clinical Trials
19 Citations (Scopus)

Resilience in Aging Mice

Kirkland, J. L., Stout, M. B. & Sierra, F., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1407-1414 8 p.

Research output: Contribution to journalArticle

Animal Models
Health
Research
Blood Vessels
Research Personnel