• 6583 Citations
  • 41 Scopus h-Index
19952020
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Research Output 1995 2019

  • 6583 Citations
  • 41 Scopus h-Index
  • 96 Article
  • 4 Chapter
  • 3 Review article
  • 1 Short survey
1995
455 Citations (Scopus)

PKC ζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid

Muller, G., Ayoub, M., Storz, P., Rennecke, J., Fabbro, D. & Pfizenmaier, K., 1995, In : EMBO Journal. 14, 9, p. 1961-1969 9 p.

Research output: Contribution to journalArticle

Signal transduction
Ceramides
Arachidonic Acid
Signal Transduction
Tumor Necrosis Factor-alpha
1998
99 Citations (Scopus)

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

Müller, G., Storz, P., Bourteele, S., Döppler, H., Pfizenmaier, K., Mischak, H., Philipp, A., Kaiser, C. & Kolch, W., Feb 2 1998, In : EMBO Journal. 17, 3, p. 732-742 11 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-raf
Ceramides
Second Messenger Systems
Tumor Necrosis Factor-alpha
Signal Transduction
29 Citations (Scopus)

TNF inhibits insulin induced STAT5 activation in differentiated mouse muscle cells pmi28

Storz, P., Döppler, H., Wernig, A., Pfizenmaier, K. & Müller, G., Nov 27 1998, In : FEBS Letters. 440, 1-2, p. 41-45 5 p.

Research output: Contribution to journalArticle

Muscle Cells
Muscle
Tumor Necrosis Factor-alpha
Chemical activation
Cells
1999
17 Citations (Scopus)

A cellular reporter assay to monitor insulin receptor kinase activity based on STAT 5-dependent luciferase gene expression

Storz, P., Döppler, H., Horn-Müller, J., Groner, B., Pfizenmaier, K. & Müller, G., Dec 1 1999, In : Analytical Biochemistry. 276, 1, p. 97-104 8 p.

Research output: Contribution to journalArticle

Insulin Receptor
Luciferases
Gene expression
STAT5 Transcription Factor
Assays
39 Citations (Scopus)

Bruton's tyrosine kinase (Btk) associates with protein kinase C μ

Johannes, F. J., Hausser, A., Storz, P., Truckenmüller, L., Link, G., Kawakami, T. & Pfizenmaier, K., Nov 12 1999, In : FEBS Letters. 461, 1-2, p. 68-72 5 p.

Research output: Contribution to journalArticle

Protein Kinase C
B-Lymphocytes
Cells
Antigen Receptors
Agammaglobulinaemia tyrosine kinase
88 Citations (Scopus)
Proto-Oncogene Proteins c-akt
Palmitates
Muscle Cells
Muscle
Insulin Resistance
31 Citations (Scopus)

Insulin selectively activates STAT5b, but not STAT5a, via a JAK2- independent signalling pathway in Kym-1 rhabdomyosarcoma cells

Storz, P., Döppler, H., Pfizenmaier, K. & Müller, G., Dec 31 1999, In : FEBS Letters. 464, 3, p. 159-163 5 p.

Research output: Contribution to journalArticle

Phosphorylation
Insulin Receptor
Janus Kinases
Phosphotransferases
Chemical activation
87 Citations (Scopus)

Protein kinase C μ is negatively regulated by 14-3-3 signal transduction proteins

Hausser, A., Storz, P., Link, G., Stoll, H., Liu, Y. C., Altman, A., Pfizenmaier, K. & Johannes, F. J., Apr 2 1999, In : Journal of Biological Chemistry. 274, 14, p. 9258-9264 7 p.

Research output: Contribution to journalArticle

Signal transduction
Protein Kinase C
Signal Transduction
14-3-3 Proteins
Proteins
2000
72 Citations (Scopus)

Protein kinase C μ is regulated by the multifunctional chaperon protein p32

Storz, P., Hausser, A., Link, G., Dedio, J., Ghebrehiwet, B., Pfizenmaier, K. & Johannes, F. J., Aug 11 2000, In : Journal of Biological Chemistry. 275, 32, p. 24601-24607 7 p.

Research output: Contribution to journalArticle

Protein Kinase C
Proteins
Phosphotransferases
Assays
complement 1q receptor
11 Citations (Scopus)
Receptor Protein-Tyrosine Kinases
Signal Transduction
Down-Regulation
Cytostatic Agents
Somatomedins
2001
53 Citations (Scopus)

Protein kinase C μ selectively activates the mitogen-activated protein kinase (MAPK) p42 pathway

Hausser, A., Storz, P., Hübner, S., Braendlin, I., Martinez-Moya, M., Link, G. & Johannes, F. J., Mar 9 2001, In : FEBS Letters. 492, 1-2, p. 39-44 6 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 1
Protein Kinase C
Serum Response Element
Mitogen-Activated Protein Kinases
Chemical activation
2002
101 Citations (Scopus)
3-Phosphoinositide-Dependent Protein Kinases
Phosphatidylinositol 3-Kinases
Phosphotransferases
1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
102 Citations (Scopus)

Protein kinase C (PKC)η-mediated PKCμ activation modulates ERK and JNK signal pathways

Brändlin, I., Hübner, S., Eiseler, T., Martinez-Moya, M., Horschinek, A., Hausser, A., Link, G., Rupp, S., Storz, P., Pfizenmaier, K. & Johannes, F. J., Feb 22 2002, In : Journal of Biological Chemistry. 277, 8, p. 6490-6496 7 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Protein Kinase C
Signal Transduction
Chemical activation
Phosphorylation
2003
46 Citations (Scopus)

NF-kappaB signaling--an alternate pathway for oxidative stress responses.

Storz, P. & Toker, A., Jan 2003, In : Cell cycle (Georgetown, Tex.). 2, 1, p. 9-10 2 p.

Research output: Contribution to journalArticle

I-kappa B Proteins
NF-kappa B
Eukaryotic Cells
Protein Kinase C
Signal Transduction
233 Citations (Scopus)

Protein kinase D mediates a stress-induced NF-κB activation and survival pathway

Storz, P. & Toker, A., Jan 2 2003, In : EMBO Journal. 22, 1, p. 109-120 12 p.

Research output: Contribution to journalArticle

Oxidative stress
Oxidative Stress
Chemical activation
Phosphorylation
Protein-Tyrosine Kinases
95 Citations (Scopus)

Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation

Storz, P., Döppler, H., Johannes, F. J. & Toker, A., May 16 2003, In : Journal of Biological Chemistry. 278, 20, p. 17969-17976 8 p.

Research output: Contribution to journalArticle

Phosphorylation
Protein-Tyrosine Kinases
Tyrosine
Chemical activation
Protein Kinase C
2004
90 Citations (Scopus)

Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor κB

Storz, P., Döppler, H. & Toker, A., Oct 2004, In : Molecular Pharmacology. 66, 4, p. 870-879 10 p.

Research output: Contribution to journalArticle

Phosphorylation
Oxidative Stress
Protein Kinase C
Phosphotransferases
Antioxidants
254 Citations (Scopus)

A rapid method for determining protein kinase phosphorylation specificity.

Hutti, J. E., Jarrell, E. T., Chang, J. D., Abbott, D. W., Storz, P., Toker, A., Cantley, L. C. & Turk, B. E., Oct 2004, In : Nat Methods. 1, 1, p. 27-29 3 p.

Research output: Contribution to journalArticle

Phosphorylation
Protein Kinases
Substrates
Peptide Library
Peptides
64 Citations (Scopus)

Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1

Wang, Y., Schattenberg, J. M., Rigoli, R. M., Storz, P. & Czaja, M. J., Jul 23 2004, In : Journal of Biological Chemistry. 279, 30, p. 31089-31097 9 p.

Research output: Contribution to journalArticle

Vitamin K 3
Oxidative stress
Transcription Factor AP-1
Protein Kinase C
Hepatocytes
170 Citations (Scopus)

Protein Kinase Cδ Selectively Regulates Protein Kinase D-Dependent Activation of NF-κB in Oxidative Stress Signaling

Storz, P., Döppler, H. & Toker, A., Apr 2004, In : Molecular and Cellular Biology. 24, 7, p. 2614-2626 13 p.

Research output: Contribution to journalArticle

Protein Kinase C
Oxidative Stress
Phosphorylation
src-Family Kinases
protein kinase D
2005
51 Citations (Scopus)

Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo

Kraft, S., Fleming, T., Billingsley, J. M., Lin, S. Y., Jouvin, M. H., Storz, P. & Kinet, J. P., Feb 7 2005, In : Journal of Experimental Medicine. 201, 3, p. 385-396 12 p.

Research output: Contribution to journalArticle

Immunoglobulin E
Extracellular Matrix Proteins
Anti-Idiotypic Antibodies
Hypersensitivity
Mast Cells
130 Citations (Scopus)

A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D

Döppler, H., Storz, P., Li, J., Comb, M. J. & Toker, A., Apr 15 2005, In : Journal of Biological Chemistry. 280, 15, p. 15013-15019 7 p.

Research output: Contribution to journalArticle

Phospho-Specific Antibodies
Substrates
Antibodies
Protein Kinases
Cell signaling
45 Citations (Scopus)

Functional dichotomy of A20 in apoptotic and necrotic cell death

Storz, P., Döppler, H., Ferran, C., Grey, S. T. & Toker, A., Apr 1 2005, In : Biochemical Journal. 387, 1, p. 47-55 9 p.

Research output: Contribution to journalArticle

Oxidative stress
Cell death
Oxidative Stress
Cell Death
Reactive Oxygen Species
156 Citations (Scopus)

Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species

Storz, P., Döppler, H. & Toker, A., Oct 2005, In : Molecular and Cellular Biology. 25, 19, p. 8520-8530 11 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Mitochondria
Superoxide Dismutase
Transcription Factors
Protein-Serine-Threonine Kinases
237 Citations (Scopus)

Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex

Hausser, A., Storz, P., Märtens, S., Link, G., Toker, A. & Pfizenmaier, K., Sep 2005, In : Nature Cell Biology. 7, 9, p. 880-886 7 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Golgi Apparatus
trans-Golgi Network
Protein Transport
Protein Isoforms
83 Citations (Scopus)

Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor

Zhang, W., Zheng, S., Storz, P. & Min, W., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 19036-19044 9 p.

Research output: Contribution to journalArticle

MAP Kinase Kinase Kinase 5
JNK Mitogen-Activated Protein Kinases
Tumor Necrosis Factor-alpha
Chemical activation
14-3-3 Proteins
558 Citations (Scopus)

Reactive oxygen species in tumor progression

Storz, P., 2005, In : Frontiers in Bioscience. 10, 2, p. 1881-1896 16 p.

Research output: Contribution to journalArticle

Tumors
Reactive Oxygen Species
Neoplasms
Cells
Antioxidants
2006
74 Citations (Scopus)
Mitochondria
Reactive Oxygen Species
Antioxidants
Aging of materials
Proteins
2007
54 Citations (Scopus)

A novel tyrosine phosphorylation site in protein kinase D contributes to oxidative stress-mediated activation

Döppler, H. & Storz, P., Nov 2 2007, In : Journal of Biological Chemistry. 282, 44, p. 31873-31881 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Oxidative stress
Protein Kinases
Tyrosine
Oxidative Stress
80 Citations (Scopus)

Mitochondrial ROS - radical detoxification, mediated by protein kinase D

Storz, P., Jan 2007, In : Trends in Cell Biology. 17, 1, p. 13-18 6 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Mitochondria
Oxidative Stress
Protein-Serine-Threonine Kinases
Electron Transport
2008
36 Citations (Scopus)

Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association

Watkins, J. L., Lewandowski, K. T., Meek, S. E. M., Storz, P., Toker, A. & Piwnica-Worms, H., Nov 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 47, p. 18378-18383 6 p.

Research output: Contribution to journalArticle

Phosphotransferases
Phosphorylation
Serine
Membranes
Acetates
2009
79 Citations (Scopus)

FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases

Storz, P., Döppler, H., Copland, J. A. III., Simpson, K. J. & Toker, A., Sep 2009, In : Molecular and Cellular Biology. 29, 18, p. 4906-4917 12 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Neoplasms
Forkhead Transcription Factors
Matrix Metalloproteinase 9
Starvation
45 Citations (Scopus)

Loss of cell-cell contacts induces NF-κB via RhoA-mediated activation of protein kinase D1

Cowell, C. F., Yan, I. K., Eiseler, T., Leightner, A. C., Döppler, H. & Storz, P., Mar 1 2009, In : Journal of Cellular Biochemistry. 106, 4, p. 714-728 15 p.

Research output: Contribution to journalArticle

Protein Kinases
Chemical activation
Cytology
rho GTP-Binding Proteins
src-Family Kinases
35 Citations (Scopus)

Mitochondrial diacylglycerol initiates protein-kinase-D1-mediated ROS signaling

Cowell, C. F., Döppler, H., Yan, I. K., Hausser, A., Umazawa, Y. & Storz, P., Apr 1 2009, In : Journal of Cell Science. 122, 7, p. 919-928 10 p.

Research output: Contribution to journalArticle

Diglycerides
Protein Kinases
Reactive Oxygen Species
Mitochondria
Protein-Serine-Threonine Kinases
11 Citations (Scopus)

Protein kinase D1: A novel regulator of actin-driven directed cell migration

Storz, P., Jul 1 2009, In : Cell Cycle. 8, 13, p. 1975-1976 2 p.

Research output: Contribution to journalArticle

Actin Depolymerizing Factors
Protein Kinases
Cell Movement
Actins
162 Citations (Scopus)

Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot

Eiseler, T., Döppler, H., Yan, I. K., Kitatani, K., Mizuno, K. & Storz, P., 2009, In : Nature Cell Biology. 11, 5, p. 545-556 12 p.

Research output: Contribution to journalArticle

Actin Depolymerizing Factors
Protein Kinases
Cell Movement
Actins
Pseudopodia
99 Citations (Scopus)

Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion

Eiseler, T., Döppler, H., Yan, I. K., Goodison, S. & Storz, P., Feb 25 2009, In : Breast Cancer Research. 11, 1, R13.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Protein Kinases
Breast Neoplasms
Cell Line
Aptitude
2010
981 Citations (Scopus)

Reactive oxygen species in cancer

Liou, G. Y. & Storz, P., 2010, In : Free Radical Research. 44, 5, p. 479-496 18 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Tumors
Neoplasms
Cells
Antioxidants
2011
177 Citations (Scopus)

Forkhead homeobox type O transcription factors in the responses to oxidative stress

Storz, P., Feb 15 2011, In : Antioxidants and Redox Signaling. 14, 4, p. 593-605 13 p.

Research output: Contribution to journalArticle

Oxidative stress
Homeobox Genes
Reactive Oxygen Species
Oxidative Stress
Transcription Factors
50 Citations (Scopus)

Protein kinase D regulates cofilin activity through p21-activated kinase 4

Spratley, S. J., Bastea, L. I., Döppler, H., Mizuno, K. & Storz, P., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 34254-34261 8 p.

Research output: Contribution to journalArticle

p21-Activated Kinases
Actin Depolymerizing Factors
Phosphorylation
Actins
Lim Kinases
2012
261 Citations (Scopus)

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

Ardito, C. M., Grüner, B. M., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P. K., DelGiorno, K. E., Carpenter, E. S., Halbrook, C. J., Hall, J. C., Pal, D., Briel, T., Herner, A., Trajkovic-Arsic, M., Sipos, B., Liou, G. Y., Storz, P., Murray, N. R., Threadgill, D. W., Sibilia, M. & 6 others, Washington, M. K., Wilson, C. L., Schmid, R. M., Raines, E. W., Crawford, H. C. & Siveke, J. T., Sep 11 2012, In : Cancer Cell. 22, 3, p. 304-317 14 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Carcinogenesis
Adenocarcinoma
Mitogen-Activated Protein Kinase Kinases
Oncogenes
19 Citations (Scopus)

Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: A paradigm shift that impacts current therapeutic strategies

Marlow, L. A., von Roemeling, C. A., Cooper, S. J., Zhang, Y., Rohl, S. D., Arora, S., Gonzales, I. M., Azorsa, D. O., Reddi, H. V., Tun, H. W., Dö ppler, H. R., Storz, P., Smallridge, R. C. & Copland, J. A. III., 2012, In : Journal of Cell Science. 125, 18, p. 4253-4263 11 p.

Research output: Contribution to journalArticle

Cyclin A1
Neoplasms
Therapeutics
Cell Cycle
Up-Regulation
6 Citations (Scopus)

Oxidative stress in cancer

Storz, P., Sep 1 2012, Oxidative Stress and Redox Regulation. Springer Netherlands, Vol. 9789400757875. p. 427-447 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Oxidative stress
Tumors
Oxidative Stress
Reactive Oxygen Species
Neoplasms
29 Citations (Scopus)

Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex

Bastea, L. I., Döppler, H., Balogun, B. & Storz, P., Jan 20 2012, In : PLoS One. 7, 1, e30459.

Research output: Contribution to journalArticle

cadherins
Cadherins
protein kinases
Protein Kinases
Phosphorylation
26 Citations (Scopus)

Protein kinase D1 mediates anchorage-dependent and -independent growth of tumor cells via the zinc finger transcription factor snail

Eiseler, T., Köhler, C., Nimmagadda, S. C., Jamali, A., Funk, N., Joodi, G., Storz, P. & Seufferlein, T., Sep 21 2012, In : Journal of Biological Chemistry. 287, 39, p. 32367-32380 14 p.

Research output: Contribution to journalArticle

Zinc Fingers
Protein Kinases
Zinc
Tumors
Transcription Factors
2 Citations (Scopus)

Protein kinase D signaling in cancer

Storz, P., May 1 2012, Cell Signaling & Molecular Targets in Cancer. Springer New York, Vol. 9781461407300. p. 245-271 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neoplasms
src-Family Kinases
Protein-Serine-Threonine Kinases
Diglycerides
Phorbol Esters
57 Citations (Scopus)

VEGF and angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx

Ngok, S. P., Geyer, R., Liu, M., Kourtidis, A., Agrawal, S., Wu, C., Seerapu, H. R., Lewis-Tuffin, L. J., Moodie, K. L., Huveldt, D., Marx, R., Baraban, J. M., Storz, P., Horowitz, A. & Anastasiadis, P. Z., Dec 2012, In : Journal of Cell Biology. 199, 7, p. 1103-1115 13 p.

Research output: Contribution to journalArticle

Angiopoietin-1
Intercellular Junctions
Vascular Endothelial Growth Factor A
Endothelial Cells
Guanine Nucleotide Exchange Factors
2013
21 Citations (Scopus)

Downregulation of TRAF2 Mediates NIK-Induced Pancreatic Cancer Cell Proliferation and Tumorigenicity

Döppler, H., Liou, G. Y. & Storz, P., Jan 3 2013, In : PLoS One. 8, 1, e53676.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 2
pancreatic neoplasms
Cell proliferation
adenocarcinoma
Pancreatic Neoplasms
108 Citations (Scopus)

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-ΚB and MMPs

Liou, G. Y., Döppler, H., Necela, B., Krishna, M., Crawford, H. C., Raimondo, M. & Storz, P., 2013, In : Journal of Cell Biology. 202, 3, p. 563-577 15 p.

Research output: Contribution to journalArticle

Metaplasia
Matrix Metalloproteinases
Macrophages
Cytokines
Chemokine CCL5
15 Citations (Scopus)

Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 protein

Döppler, H., Bastea, L. I., Eiseler, T. & Storz, P., Jan 4 2013, In : Journal of Biological Chemistry. 288, 1, p. 455-465 11 p.

Research output: Contribution to journalArticle

rac1 GTP-Binding Protein
Neuregulins
Cell Migration Inhibition
Protein Kinases
Cell Movement