• 6972 Citations
  • 41 Scopus h-Index
19952020

Research output per year

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Research Output

2019

Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture

Fleming Martinez, A. K. & Storz, P., Feb 11 2019, In : Journal of visualized experiments : JoVE. 144

Research output: Contribution to journalArticle

1 Scopus citations

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis

Liu, X., Clemens, D. L., Grunkemeyer, J. A., Price, J. D., O’Connell, K., Chapman, N. M., Storz, P., Wen, H., Cox, J. L., Reid, W. L., Hollingsworth, M. A. & Thayer, S., Dec 1 2019, In : Scientific reports. 9, 1, 10656.

Research output: Contribution to journalArticle

Open Access

Pomalidomide alters pancreatic macrophage populations to generate an immune-responsive environment at precancerous and cancerous lesions

Bastea, L. I., Liou, G. Y., Pandey, V., Fleming, A. K., Von Roemeling, C. A., Doeppler, H., Li, Z., Qiu, Y., Edenfield, B., Copland, J. A., Tun, H. W. & Storz, P., Apr 1 2019, In : Cancer research. 79, 7, p. 1535-1548 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Protein kinase D up-regulates transcription of VEGF receptor-2 in endothelial cells by suppressing nuclear localization of the transcription factor AP2β

Wang, Y., Hoeppner, L. H., Angom, R. S., Wang, E., Dutta, S., Doeppler, H. R., Wang, F., Shen, T., Scarisbrick, I. A., Guha, S., Storz, P., Bhattacharya, R. & Mukhopadhyay, D., Oct 25 2019, In : Journal of Biological Chemistry. 294, 43, p. 15759-15767 9 p.

Research output: Contribution to journalArticle

Sangivamycin and its derivatives inhibit Haspin-Histone H3-survivin signaling and induce pancreatic cancer cell death

Bastea, L. I., Hollant, L. M. A., Döppler, H. R., Reid, E. M. & Storz, P., Dec 1 2019, In : Scientific reports. 9, 1, 16588.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Targeting the tumor microenvironment in pancreatic ductal adenocarcinoma

Pandey, V. & Storz, P., Jun 1 2019, In : Expert review of anticancer therapy. 19, 6, p. 473-482 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Protein kinase D1: Gatekeeper of the epithelial phenotype and key regulator of cancer metastasis?

Storz, P., Feb 20 2018, In : British Journal of Cancer. 118, 4, p. 459-461 3 p.

Research output: Contribution to journalReview article

1 Scopus citations

The phosphorylation status of PIP5K1C at serine 448 can be predictive for invasive ductal carcinoma of the breast

Durand, N., Borges, S., Hall, T., Bastea, L., Döppler, H., Edenfield, B. H., Thompson, E. A., Geiger, X. & Storz, P., Nov 1 2018, In : Oncotarget. 9, 91, p. 36358-36370 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Acinar cell plasticity and development of pancreatic ductal adenocarcinoma

Storz, P., Mar 8 2017, (Accepted/In press) In : Nature Reviews Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

52 Scopus citations

A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance

Spechler, S. J., Merchant, J. L., Wang, T. C., Chandrasoma, P., Fox, J. G., Genta, R. M., Goldenring, J. R., Hayakawa, Y., Kuipers, E. J., Lund, P. K., McKeon, F., Mills, J. C., Odze, R. D., Peek, R. M., Pham, T., Que, J., Rustgi, A. K., Shaheen, N. J., Shivdasani, R. A., Souza, R. F. & 4 others, Storz, P., Todisco, A., Wang, D. H. & Wright, N. A., Jul 2017, In : Gastroenterology. 153, 1, p. e6-e13

Research output: Contribution to journalArticle

7 Scopus citations

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

Cobbaut, M., Derua, R., Döppler, H., Lou, H. J., Vandoninck, S., Storz, P., Turk, B. E., Seufferlein, T., Waelkens, E., Janssens, V. & Van Lint, J., Dec 1 2017, In : Scientific Reports. 7, 1, 00800.

Research output: Contribution to journalArticle

7 Scopus citations

Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia

Ding, L., Liou, G. Y., Schmitt, D. M., Storz, P., Zhang, J. S. & Billadeau, D. D., Sep 1 2017, In : Journal of Pathology. 243, 1, p. 65-77 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mitochondrial and oxidative stress-mediated activation of protein kinase d1 and its importance in pancreatic cancer

Döppler, H. & Storz, P., Mar 15 2017, In : Frontiers in Oncology. 7, MAR, 41.

Research output: Contribution to journalShort survey

12 Scopus citations

Paracrine Secretion of Transforming Growth Factor β by Ductal Cells Promotes Acinar-to-Ductal Metaplasia in Cultured Human Exocrine Pancreas Tissues

Akanuma, N., Liu, J., Liou, G. Y., Yin, X., Bejar, K. R., Liu, C., Sun, L. Z., Storz, P. & Wang, P., Oct 1 2017, In : Pancreas. 46, 9, p. 1202-1207 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Protein kinase C isoforms in the normal pancreas and in pancreatic disease

Fleming, A. K. & Storz, P., Dec 1 2017, In : Cellular Signalling. 40, p. 1-9 9 p.

Research output: Contribution to journalReview article

6 Scopus citations

Src-mediated tyrosine phosphorylation of Protein Kinase D2 at focal adhesions regulates cell adhesion

Durand, N., Bastea, L. I., Döppler, H., Eiseler, T. & Storz, P., Dec 1 2017, In : Scientific Reports. 7, 1, 9524.

Research output: Contribution to journalArticle

4 Scopus citations

Targeting reactive oxygen species in development and progression of pancreatic cancer

Durand, N. & Storz, P., Jan 2 2017, In : Expert Review of Anticancer Therapy. 17, 1, p. 19-31 13 p.

Research output: Contribution to journalReview article

20 Scopus citations

The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis

Liou, G. Y., Bastea, L., Fleming, A., Döppler, H., Edenfield, B. H., Dawson, D. W., Zhang, L., Bardeesy, N. & Storz, P., May 16 2017, In : Cell Reports. 19, 7, p. 1322-1333 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
2016

A bright future for protein kinase D1 as a drug target to prevent or treat pancreatic cancer

Liou, G. Y., Storz, P. & Leitges, M., Jan 2 2016, In : Molecular and Cellular Oncology. 3, 1, e1035477.

Research output: Contribution to journalArticle

2 Scopus citations

KRas, ROS and the initiation of pancreatic cancer

Storz, P., Jun 15 2016, (Accepted/In press) In : Small GTPases. p. 1-5 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Legumain is activated in macrophages during pancreatitis

Edgington-Mitchell, L. E., Wartmann, T., Fleming, A. K., Gocheva, V., Van Der Linden, W. A., Withana, N. P., Verdoes, M., Aurelio, L., Edgington-Mitchell, D., Lieu, T., Parker, B. S., Graham, B., Reinheckel, T., Furness, J. B., Joyce, J. A., Storz, P., Halangk, W., Bogyo, M. & Bunnett, N. W., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 3, p. G548-G560

Research output: Contribution to journalArticle

12 Scopus citations

LPA/PKD-1-FoxO1 signaling axis mediates endothelial cell CD36 transcriptional repression and proangiogenic and proarteriogenic reprogramming

Ren, B., Best, B., Ramakrishnan, D. P., Walcott, B. P., Storz, P. & Silverstein, R. L., Jun 1 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 6, p. 1197-1208 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

Liou, G. Y., Döppler, H., DelGiorno, K. E., Zhang, L., Leitges, M., Crawford, H. C., Murphy, M. P. & Storz, P., Mar 15 2016, In : Cell Reports. 14, 10, p. 2325-2336 12 p.

Research output: Contribution to journalArticle

61 Scopus citations

NFATc4 Regulates Sox9 gene expression in acinar cell plasticity and pancreatic cancer initiation

Hessmann, E., Zhang, J. S., Chen, N. M., Hasselluhn, M., Liou, G. Y., Storz, P., Ellenrieder, V., Billadeau, D. D. & Koenig, A., 2016, In : Stem Cells International. 2016, 5272498.

Research output: Contribution to journalArticle

15 Scopus citations

Osteopontin is a multi-faceted pro-tumorigenic driver for central nervous system lymphoma

Yushi, Q., Li, Z., Von Roemeling, C. A., Doeppler, H., Marlow, L. A., Kim, Y. S. B., Radisky, D. C., Storz, P., Copland, J. A. III. & Tun, H. W., May 31 2016, In : Oncotarget. 7, 22, p. 32156-32171 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Protein Kinase D1 regulates focal adhesion dynamics and cell adhesion through Phosphatidylinositol-4-phosphate 5-kinase type-l 3

Durand, N., Bastea, L. I., Long, J., Döppler, H., Ling, K. & Storz, P., Oct 24 2016, In : Scientific Reports. 6, 35963.

Research output: Contribution to journalArticle

6 Scopus citations

Strategies to target pancreatic cancer

Liou, G. Y. & Storz, P., Jan 1 2016, Molecular Targets and Strategies in Cancer Prevention. Springer International Publishing, p. 1-20 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The PRKD1 promoter is a target of the KRas-NF-κ B pathway in pancreatic cancer

Döppler, H., Panayiotou, R., Reid, E. M., Maimo, W., Bastea, L. & Storz, P., Sep 21 2016, In : Scientific Reports. 6, 33758.

Research output: Contribution to journalArticle

7 Scopus citations

Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages

Colonne, P. M., Winchell, C. G., Graham, J. G., Onyilagha, F. I., MacDonald, L. J., Doeppler, H. R., Storz, P., Kurten, R. C., Beare, P. A., Heinzen, R. A. & Voth, D. E., Oct 1 2016, In : PLoS Pathogens. 12, 10, e1005915.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Detecting reactive oxygen species by immunohistochemistry

Liou, G. Y. & Storz, P., Mar 24 2015, Stress Responses: Methods and Protocols. Springer New York, p. 97-104 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Detecting reactive oxygen species by immunohistochemistry

Liou, G. Y. & Storz, P., 2015, In : Methods in Molecular Biology. 1292, p. 97-104 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Differences in metabolic programming define the site of breast cancer cell metastasis

Döppler, H. & Storz, P., Oct 6 2015, In : Cell Metabolism. 22, 4, p. 536-537 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity

Kourtidis, A., Ngok, S. P., Pulimeno, P., Feathers, R. W., Carpio, L. R., Baker, T. R., Carr, J. M., Yan, I. K., Borges, S., Perez, E. A., Storz, P., Copland, J. A. III., Patel, T. C., Thompson, E. A., Citi, S. & Anastasiadis, P. Z., Sep 1 2015, In : Nature. 17, 9, p. 1145-1157 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

Effective targeting of estrogen receptor-negative breast cancers with the protein kinase D inhibitor CRT0066101

Borges, S., Perez, E. A., Thompson, E. A., Radisky, D. C., Geiger, X. J. & Storz, P., Jun 1 2015, In : Molecular Cancer Therapeutics. 14, 6, p. 1306-1316 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer

Durand, N., Borges, S. & Storz, P., Nov 1 2015, In : Cellular and Molecular Life Sciences. 72, 22, p. 4369-4382 14 p.

Research output: Contribution to journalReview article

13 Scopus citations

Inflammatory macrophages in pancreatic acinar cell metaplasia and initiation of pancreatic cancer

Liou, G. Y. & Storz, P., Jan 1 2015, In : Oncoscience. 2, 3, p. 247-251 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mutant KRAS–induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions

Liou, G. Y., Döppler, H., Necela, B., Edenfield, B., Zhang, L., Dawson, D. W. & Storz, P., Jan 1 2015, In : Cancer discovery. 5, 1, p. 52-63 12 p.

Research output: Contribution to journalArticle

68 Scopus citations

NFATc1 links EGFR signaling to induction of sox9 transcription and acinar-ductal transdifferentiation in the pancreas

Chen, N. M., Singh, G., Koenig, A., Liou, G. Y., Storz, P., Zhang, J. S., Regul, L., Nagarajan, S., Kühnemuth, B., Johnsen, S., Hebrok, M., Siveke, J., Billadeau, D. D., Ellenrieder, V. & Hessmann, E., May 1 2015, In : Gastroenterology. 148, 5, p. 1024-1034.e9

Research output: Contribution to journalArticle

31 Scopus citations

Pancreatic oncogenic signaling cascades converge at Protein Kinase D1

Liou, G. Y., Leitges, M. & Storz, P., Jan 1 2015, In : Cell Cycle. 14, 10, p. 1489-1490 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

Liou, G. Y., Döppler, H., Braun, U. B., Panayiotou, R., Scotti Buzhardt, M., Radisky, D. C., Crawford, H. C., Fields, A. P., Murray, N. R., Wang, Q. J., Leitges, M. & Storz, P., Feb 20 2015, In : Nature communications. 6, 6200.

Research output: Contribution to journalArticle

35 Scopus citations

Protein kinase D enzymes: Novel kinase targets in pancreatic cancer

Liou, G. Y. & Storz, P., Sep 2 2015, In : Expert Review of Gastroenterology and Hepatology. 9, 9, p. 1143-1146 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Targeting protein kinase C subtypes in pancreatic cancer

Storz, P., Apr 1 2015, In : Expert review of anticancer therapy. 15, 4, p. 433-438 6 p.

Research output: Contribution to journalReview article

8 Scopus citations
4 Scopus citations

The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma

Döppler, H., Bastea, L., Borges, S., Geiger, X. & Storz, P., Jan 1 2015, In : Oncotarget. 6, 30, p. 29740-29752 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells

Borges, S., Döppler, H. R. & Storz, P., Feb 2014, In : Breast Cancer Research and Treatment. 144, 1, p. 79-91 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

PKD1 Phosphorylation-Dependent Degradation of SNAIL by SCF-FBXO11 Regulates Epithelial-Mesenchymal Transition and Metastasis

Zheng, H., Shen, M., Zha, Y. L., Li, W., Wei, Y., Blanco, M. A., Ren, G., Zhou, T., Storz, P., Wang, H. Y. & Kang, Y., Jan 1 2014, In : Cancer cell. 26, 3, p. 358-373 16 p.

Research output: Contribution to journalArticle

119 Scopus citations

Protein kinase D isoforms differentially modulate cofilin-driven directed cell migration

Döppler, H., Bastea, L. I., Borges, S., Spratley, S. J., Pearce, S. E. & Storz, P., May 19 2014, In : PloS one. 9, 5, e98090.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Downregulation of TRAF2 Mediates NIK-Induced Pancreatic Cancer Cell Proliferation and Tumorigenicity

Döppler, H., Liou, G. Y. & Storz, P., Jan 3 2013, In : PloS one. 8, 1, e53676.

Research output: Contribution to journalArticle

24 Scopus citations

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-ΚB and MMPs

Liou, G. Y., Döppler, H., Necela, B., Krishna, M., Crawford, H. C., Raimondo, M. & Storz, P., Sep 23 2013, In : Journal of Cell Biology. 202, 3, p. 563-577 15 p.

Research output: Contribution to journalArticle

115 Scopus citations

Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 protein

Döppler, H., Bastea, L. I., Eiseler, T. & Storz, P., Jan 4 2013, In : Journal of Biological Chemistry. 288, 1, p. 455-465 11 p.

Research output: Contribution to journalArticle

17 Scopus citations