Peter Storz, PhD &ndash; Research Output

2013

Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis

Borges, S., Döppler, H., Perez, E. A., Andorfer, C. A., Sun, Z. D., Anastasiadis, P. Z., Thompson, E. A., Geiger, X. J. & Storz, P., Aug 23 2013, In : Breast Cancer Research. 15, 2, R66.

Research output: Contribution to journal › Article

Epigenomics

Protein Kinases

decitabine

Breast Neoplasms

Neoplasm Metastasis

10 Citations (Scopus)

Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) syx

Ngok, S. P., Geyer, R., Kourtidis, A., Storz, P. & Anastasiadis, P. Z., Mar 1 2013, In : Journal of Biological Chemistry. 288, 9, p. 6640-6650 11 p.

Research output: Contribution to journal › Article

Rho Guanine Nucleotide Exchange Factors

14-3-3 Proteins

Guanine Nucleotide Exchange Factors

Phosphorylation

Protein Binding

21 Citations (Scopus)

Protein kinase D1-mediated phosphorylations regulate Vasodilator-stimulated phosphoprotein (VASP) localization and cell migration

Döppler, H. R., Bastea, L. I., Lewis-Tuffin, L. J., Anastasiadis, P. Z. & Storz, P., Aug 23 2013, In : Journal of Biological Chemistry. 288, 34, p. 24382-24393 12 p.

Research output: Contribution to journal › Article

Phosphorylation

Protein Kinases

Cell Movement

Focal Adhesions

Actins

8 Citations (Scopus)

Protein kinase D isoforms: New targets for therapy in invasive breast cancers?

Borges, S. & Storz, P., Aug 2013, In : Expert Review of Anticancer Therapy. 13, 8, p. 895-898 4 p.

Research output: Contribution to journal › Article

Neoplasm Invasiveness

Molecular Targeted Therapy

Antineoplastic Agents

Protein Kinase C

Isoenzymes

13 Citations (Scopus)

Protein kinase D-mediated phosphorylation at Ser99 regulates localization of p21-activated kinase 4

Bastea, L. I., Döppler, H., Pearce, S. E., Durand, N., Spratley, S. J. & Storz, P., Oct 15 2013, In : Biochemical Journal. 455, 2, p. 251-260 10 p.

Research output: Contribution to journal › Article

p21-Activated Kinases

Phosphorylation

Actin Depolymerizing Factors

Phosphotransferases

Protein Kinases

20 Citations (Scopus)

Regulation of VASP by phosphorylation Consequences for cell migration

Döppler, H. & Storz, P., Nov 2013, In : Cell Adhesion and Migration. 7, 6, p. 482-486 5 p.

Research output: Contribution to journal › Article

Cell Movement

Phosphorylation

Phosphotransferases

Pseudopodia

Focal Adhesions

14 Citations (Scopus)

Targeting the alternative NF-κB pathway in pancreatic cancer: A new direction for therapy?

Storz, P., May 2013, In : Expert Review of Anticancer Therapy. 13, 5, p. 501-504 4 p.

Research output: Contribution to journal › Article

TNF Receptor-Associated Factor 2

Molecular Targeted Therapy

NF-kappa B

Drug Design

Delayed Diagnosis

2012

261 Citations (Scopus)

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

Ardito, C. M., Grüner, B. M., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P. K., DelGiorno, K. E., Carpenter, E. S., Halbrook, C. J., Hall, J. C., Pal, D., Briel, T., Herner, A., Trajkovic-Arsic, M., Sipos, B., Liou, G. Y., Storz, P., Murray, N. R., Threadgill, D. W., Sibilia, M. & 6 others, Washington, M. K., Wilson, C. L., Schmid, R. M., Raines, E. W., Crawford, H. C. & Siveke, J. T., Sep 11 2012, In : Cancer Cell. 22, 3, p. 304-317 14 p.

Research output: Contribution to journal › Article

Epidermal Growth Factor Receptor

Carcinogenesis

Adenocarcinoma

Mitogen-Activated Protein Kinase Kinases

Oncogenes

19 Citations (Scopus)

Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: A paradigm shift that impacts current therapeutic strategies

Marlow, L. A., von Roemeling, C. A., Cooper, S. J., Zhang, Y., Rohl, S. D., Arora, S., Gonzales, I. M., Azorsa, D. O., Reddi, H. V., Tun, H. W., Dö ppler, H. R., Storz, P., Smallridge, R. C. & Copland, J. A. III., 2012, In : Journal of Cell Science. 125, 18, p. 4253-4263 11 p.

Research output: Contribution to journal › Article

Cyclin A1

Neoplasms

Therapeutics

Cell Cycle

Up-Regulation

6 Citations (Scopus)

Oxidative stress in cancer

Storz, P., Sep 1 2012, Oxidative Stress and Redox Regulation. Springer Netherlands, Vol. 9789400757875. p. 427-447 21 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Oxidative stress

Tumors

Oxidative Stress

Reactive Oxygen Species

Neoplasms

29 Citations (Scopus)

Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex

Bastea, L. I., Döppler, H., Balogun, B. & Storz, P., Jan 20 2012, In : PLoS One. 7, 1, e30459.

Research output: Contribution to journal › Article

cadherins

Cadherins

protein kinases

Protein Kinases

Phosphorylation

26 Citations (Scopus)

Protein kinase D1 mediates anchorage-dependent and -independent growth of tumor cells via the zinc finger transcription factor snail

Eiseler, T., Köhler, C., Nimmagadda, S. C., Jamali, A., Funk, N., Joodi, G., Storz, P. & Seufferlein, T., Sep 21 2012, In : Journal of Biological Chemistry. 287, 39, p. 32367-32380 14 p.

Research output: Contribution to journal › Article

Zinc Fingers

Protein Kinases

Zinc

Tumors

Transcription Factors

2 Citations (Scopus)

Protein kinase D signaling in cancer

Storz, P., May 1 2012, Cell Signaling & Molecular Targets in Cancer. Springer New York, Vol. 9781461407300. p. 245-271 27 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Neoplasms

src-Family Kinases

Protein-Serine-Threonine Kinases

Diglycerides

Phorbol Esters

57 Citations (Scopus)

VEGF and angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx

Ngok, S. P., Geyer, R., Liu, M., Kourtidis, A., Agrawal, S., Wu, C., Seerapu, H. R., Lewis-Tuffin, L. J., Moodie, K. L., Huveldt, D., Marx, R., Baraban, J. M., Storz, P., Horowitz, A. & Anastasiadis, P. Z., Dec 2012, In : Journal of Cell Biology. 199, 7, p. 1103-1115 13 p.

Research output: Contribution to journal › Article

Angiopoietin-1

Intercellular Junctions

Vascular Endothelial Growth Factor A

Endothelial Cells

Guanine Nucleotide Exchange Factors

2011

177 Citations (Scopus)

Forkhead homeobox type O transcription factors in the responses to oxidative stress

Storz, P., Feb 15 2011, In : Antioxidants and Redox Signaling. 14, 4, p. 593-605 13 p.

Research output: Contribution to journal › Article

Oxidative stress

Homeobox Genes

Reactive Oxygen Species

Oxidative Stress

Transcription Factors

50 Citations (Scopus)

Protein kinase D regulates cofilin activity through p21-activated kinase 4

Spratley, S. J., Bastea, L. I., Döppler, H., Mizuno, K. & Storz, P., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 34254-34261 8 p.

Research output: Contribution to journal › Article

p21-Activated Kinases

Actin Depolymerizing Factors

Phosphorylation

Actins

Lim Kinases

2010

981 Citations (Scopus)

Reactive oxygen species in cancer

Liou, G. Y. & Storz, P., 2010, In : Free Radical Research. 44, 5, p. 479-496 18 p.

Research output: Contribution to journal › Article

Reactive Oxygen Species

Tumors

Neoplasms

Cells

Antioxidants

2009

79 Citations (Scopus)

FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases

Storz, P., Döppler, H., Copland, J. A. III., Simpson, K. J. & Toker, A., Sep 2009, In : Molecular and Cellular Biology. 29, 18, p. 4906-4917 12 p.

Research output: Contribution to journal › Article

Matrix Metalloproteinases

Neoplasms

Forkhead Transcription Factors

Matrix Metalloproteinase 9

Starvation

45 Citations (Scopus)

Loss of cell-cell contacts induces NF-κB via RhoA-mediated activation of protein kinase D1

Cowell, C. F., Yan, I. K., Eiseler, T., Leightner, A. C., Döppler, H. & Storz, P., Mar 1 2009, In : Journal of Cellular Biochemistry. 106, 4, p. 714-728 15 p.

Research output: Contribution to journal › Article

Protein Kinases

Chemical activation

Cytology

rho GTP-Binding Proteins

src-Family Kinases

35 Citations (Scopus)

Mitochondrial diacylglycerol initiates protein-kinase-D1-mediated ROS signaling

Cowell, C. F., Döppler, H., Yan, I. K., Hausser, A., Umazawa, Y. & Storz, P., Apr 1 2009, In : Journal of Cell Science. 122, 7, p. 919-928 10 p.

Research output: Contribution to journal › Article

Diglycerides

Protein Kinases

Reactive Oxygen Species

Mitochondria

Protein-Serine-Threonine Kinases

11 Citations (Scopus)

Protein kinase D1: A novel regulator of actin-driven directed cell migration

Storz, P., Jul 1 2009, In : Cell Cycle. 8, 13, p. 1975-1976 2 p.

Research output: Contribution to journal › Article

Actin Depolymerizing Factors

Protein Kinases

Cell Movement

Actins

162 Citations (Scopus)

Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot

Eiseler, T., Döppler, H., Yan, I. K., Kitatani, K., Mizuno, K. & Storz, P., 2009, In : Nature Cell Biology. 11, 5, p. 545-556 12 p.

Research output: Contribution to journal › Article

Actin Depolymerizing Factors

Protein Kinases

Cell Movement

Actins

Pseudopodia

99 Citations (Scopus)

Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion

Eiseler, T., Döppler, H., Yan, I. K., Goodison, S. & Storz, P., Feb 25 2009, In : Breast Cancer Research. 11, 1, R13.

Research output: Contribution to journal › Article

Matrix Metalloproteinases

Protein Kinases

Breast Neoplasms

Cell Line

Aptitude

2008

36 Citations (Scopus)

Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association

Watkins, J. L., Lewandowski, K. T., Meek, S. E. M., Storz, P., Toker, A. & Piwnica-Worms, H., Nov 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 47, p. 18378-18383 6 p.

Research output: Contribution to journal › Article

Phosphotransferases

Phosphorylation

Serine

Membranes

Acetates

2007

54 Citations (Scopus)

A novel tyrosine phosphorylation site in protein kinase D contributes to oxidative stress-mediated activation

Döppler, H. & Storz, P., Nov 2 2007, In : Journal of Biological Chemistry. 282, 44, p. 31873-31881 9 p.

Research output: Contribution to journal › Article

Phosphorylation

Oxidative stress

Protein Kinases

Tyrosine

Oxidative Stress

80 Citations (Scopus)

Mitochondrial ROS - radical detoxification, mediated by protein kinase D

Storz, P., Jan 2007, In : Trends in Cell Biology. 17, 1, p. 13-18 6 p.

Research output: Contribution to journal › Article

Reactive Oxygen Species

Mitochondria

Oxidative Stress

Protein-Serine-Threonine Kinases

Electron Transport

2006

74 Citations (Scopus)

Reactive oxygen species-mediated mitochondria-to-nucleus signaling: a key to aging and radical-caused diseases.

Storz, P., Apr 25 2006, In : Science's STKE : signal transduction knowledge environment. 2006, 332

Research output: Contribution to journal › Article

Mitochondria

Reactive Oxygen Species

Antioxidants

Aging of materials

Proteins

2005

51 Citations (Scopus)

Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo

Kraft, S., Fleming, T., Billingsley, J. M., Lin, S. Y., Jouvin, M. H., Storz, P. & Kinet, J. P., Feb 7 2005, In : Journal of Experimental Medicine. 201, 3, p. 385-396 12 p.

Research output: Contribution to journal › Article

Immunoglobulin E

Extracellular Matrix Proteins

Anti-Idiotypic Antibodies

Hypersensitivity

Mast Cells

130 Citations (Scopus)

A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D

Döppler, H., Storz, P., Li, J., Comb, M. J. & Toker, A., Apr 15 2005, In : Journal of Biological Chemistry. 280, 15, p. 15013-15019 7 p.

Research output: Contribution to journal › Article

Phospho-Specific Antibodies

Substrates

Antibodies

Protein Kinases

Cell signaling

45 Citations (Scopus)

Functional dichotomy of A20 in apoptotic and necrotic cell death

Storz, P., Döppler, H., Ferran, C., Grey, S. T. & Toker, A., Apr 1 2005, In : Biochemical Journal. 387, 1, p. 47-55 9 p.

Research output: Contribution to journal › Article

Oxidative stress

Cell death

Oxidative Stress

Cell Death

Reactive Oxygen Species

156 Citations (Scopus)

Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species

Storz, P., Döppler, H. & Toker, A., Oct 2005, In : Molecular and Cellular Biology. 25, 19, p. 8520-8530 11 p.

Research output: Contribution to journal › Article

Reactive Oxygen Species

Mitochondria

Superoxide Dismutase

Transcription Factors

Protein-Serine-Threonine Kinases

237 Citations (Scopus)

Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex

Hausser, A., Storz, P., Märtens, S., Link, G., Toker, A. & Pfizenmaier, K., Sep 2005, In : Nature Cell Biology. 7, 9, p. 880-886 7 p.

Research output: Contribution to journal › Article

1-Phosphatidylinositol 4-Kinase

Golgi Apparatus

trans-Golgi Network

Protein Transport

Protein Isoforms

83 Citations (Scopus)

Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H₂O₂ but not tumor necrosis factor

Zhang, W., Zheng, S., Storz, P. & Min, W., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 19036-19044 9 p.

Research output: Contribution to journal › Article

MAP Kinase Kinase Kinase 5

JNK Mitogen-Activated Protein Kinases

Tumor Necrosis Factor-alpha

Chemical activation

14-3-3 Proteins

558 Citations (Scopus)

Reactive oxygen species in tumor progression

Storz, P., 2005, In : Frontiers in Bioscience. 10, 2, p. 1881-1896 16 p.

Research output: Contribution to journal › Article

Tumors

Reactive Oxygen Species

Neoplasms

Cells

Antioxidants

2004

90 Citations (Scopus)

Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor κB

Storz, P., Döppler, H. & Toker, A., Oct 2004, In : Molecular Pharmacology. 66, 4, p. 870-879 10 p.

Research output: Contribution to journal › Article

Phosphorylation

Oxidative Stress

Protein Kinase C

Phosphotransferases

Antioxidants

254 Citations (Scopus)

A rapid method for determining protein kinase phosphorylation specificity.

Hutti, J. E., Jarrell, E. T., Chang, J. D., Abbott, D. W., Storz, P., Toker, A., Cantley, L. C. & Turk, B. E., Oct 2004, In : Nat Methods. 1, 1, p. 27-29 3 p.

Research output: Contribution to journal › Article

Phosphorylation

Protein Kinases

Substrates

Peptide Library

Peptides

64 Citations (Scopus)

Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1

Wang, Y., Schattenberg, J. M., Rigoli, R. M., Storz, P. & Czaja, M. J., Jul 23 2004, In : Journal of Biological Chemistry. 279, 30, p. 31089-31097 9 p.

Research output: Contribution to journal › Article

Vitamin K 3

Oxidative stress

Transcription Factor AP-1

Protein Kinase C

Hepatocytes

170 Citations (Scopus)

Protein Kinase Cδ Selectively Regulates Protein Kinase D-Dependent Activation of NF-κB in Oxidative Stress Signaling

Storz, P., Döppler, H. & Toker, A., Apr 2004, In : Molecular and Cellular Biology. 24, 7, p. 2614-2626 13 p.

Research output: Contribution to journal › Article

Protein Kinase C

Oxidative Stress

Phosphorylation

src-Family Kinases

protein kinase D

2003

46 Citations (Scopus)

NF-kappaB signaling--an alternate pathway for oxidative stress responses.

Storz, P. & Toker, A., Jan 2003, In : Cell cycle (Georgetown, Tex.). 2, 1, p. 9-10 2 p.

Research output: Contribution to journal › Article

I-kappa B Proteins

NF-kappa B

Eukaryotic Cells

Protein Kinase C

Signal Transduction

233 Citations (Scopus)

Protein kinase D mediates a stress-induced NF-κB activation and survival pathway

Storz, P. & Toker, A., Jan 2 2003, In : EMBO Journal. 22, 1, p. 109-120 12 p.

Research output: Contribution to journal › Article

Oxidative stress

Oxidative Stress

Chemical activation

Phosphorylation

Protein-Tyrosine Kinases

95 Citations (Scopus)

Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation

Storz, P., Döppler, H., Johannes, F. J. & Toker, A., May 16 2003, In : Journal of Biological Chemistry. 278, 20, p. 17969-17976 8 p.

Research output: Contribution to journal › Article

Phosphorylation

Protein-Tyrosine Kinases

Tyrosine

Chemical activation

Protein Kinase C

2002

101 Citations (Scopus)

3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling.

Storz, P. & Toker, A., 2002, In : Frontiers in bioscience : a journal and virtual library. 7

Research output: Contribution to journal › Article

3-Phosphoinositide-Dependent Protein Kinases

Phosphatidylinositol 3-Kinases

Phosphotransferases

1-Phosphatidylinositol 4-Kinase

Phosphatidylinositols

102 Citations (Scopus)

Protein kinase C (PKC)η-mediated PKCμ activation modulates ERK and JNK signal pathways

Brändlin, I., Hübner, S., Eiseler, T., Martinez-Moya, M., Horschinek, A., Hausser, A., Link, G., Rupp, S., Storz, P., Pfizenmaier, K. & Johannes, F. J., Feb 22 2002, In : Journal of Biological Chemistry. 277, 8, p. 6490-6496 7 p.

Research output: Contribution to journal › Article

MAP Kinase Signaling System

Protein Kinase C

Signal Transduction

Chemical activation

Phosphorylation

2001

53 Citations (Scopus)

Protein kinase C μ selectively activates the mitogen-activated protein kinase (MAPK) p42 pathway

Hausser, A., Storz, P., Hübner, S., Braendlin, I., Martinez-Moya, M., Link, G. & Johannes, F. J., Mar 9 2001, In : FEBS Letters. 492, 1-2, p. 39-44 6 p.

Research output: Contribution to journal › Article

Mitogen-Activated Protein Kinase 1

Protein Kinase C

Serum Response Element

Mitogen-Activated Protein Kinases

Chemical activation

2000

72 Citations (Scopus)

Protein kinase C μ is regulated by the multifunctional chaperon protein p32

Storz, P., Hausser, A., Link, G., Dedio, J., Ghebrehiwet, B., Pfizenmaier, K. & Johannes, F. J., Aug 11 2000, In : Journal of Biological Chemistry. 275, 32, p. 24601-24607 7 p.

Research output: Contribution to journal › Article

Protein Kinase C

Proteins

Phosphotransferases

Assays

complement 1q receptor

11 Citations (Scopus)

TNF down-regulation of receptor tyrosine kinase-dependent mitogenic signal pathways as an important step in cytostasis induction and commitment to apoptosis of Kym-1 rhabdomyosarcoma cells

Storz, P., Doppler, H., Horn-Muller, J., Muller, G. & Pfizenmaier, K., 2000, In : Cell Death and Differentiation. 7, 10, p. 955-965 11 p.

Research output: Contribution to journal › Article

Receptor Protein-Tyrosine Kinases

Signal Transduction

Down-Regulation

Cytostatic Agents

Somatomedins

1999

17 Citations (Scopus)

A cellular reporter assay to monitor insulin receptor kinase activity based on STAT 5-dependent luciferase gene expression

Storz, P., Döppler, H., Horn-Müller, J., Groner, B., Pfizenmaier, K. & Müller, G., Dec 1 1999, In : Analytical Biochemistry. 276, 1, p. 97-104 8 p.

Research output: Contribution to journal › Article

Insulin Receptor

Luciferases

Gene expression

STAT5 Transcription Factor

Assays

39 Citations (Scopus)

Bruton's tyrosine kinase (Btk) associates with protein kinase C μ

Johannes, F. J., Hausser, A., Storz, P., Truckenmüller, L., Link, G., Kawakami, T. & Pfizenmaier, K., Nov 12 1999, In : FEBS Letters. 461, 1-2, p. 68-72 5 p.

Research output: Contribution to journal › Article

Protein Kinase C

B-Lymphocytes

Cells

Antigen Receptors

Agammaglobulinaemia tyrosine kinase

88 Citations (Scopus)

Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells. Palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/AKT stimulation and glucose uptake

Storz, P., Döppler, H., Wernig, A., Pfizenmaier, K. & Müller, G., Nov 15 1999, In : European Journal of Biochemistry. 266, 1, p. 17-25 9 p.

Research output: Contribution to journal › Article

Proto-Oncogene Proteins c-akt

Palmitates

Muscle Cells

Muscle

Insulin Resistance

31 Citations (Scopus)

Insulin selectively activates STAT5b, but not STAT5a, via a JAK2- independent signalling pathway in Kym-1 rhabdomyosarcoma cells

Storz, P., Döppler, H., Pfizenmaier, K. & Müller, G., Dec 31 1999, In : FEBS Letters. 464, 3, p. 159-163 5 p.

Research output: Contribution to journal › Article

Phosphorylation

Insulin Receptor

Janus Kinases

Phosphotransferases

Chemical activation