• 6583 Citations
  • 41 Scopus h-Index
19952020
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Research Output 1995 2019

  • 6583 Citations
  • 41 Scopus h-Index
  • 96 Article
  • 4 Chapter
  • 3 Review article
  • 1 Short survey
2013
44 Citations (Scopus)

Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis

Borges, S., Döppler, H., Perez, E. A., Andorfer, C. A., Sun, Z. D., Anastasiadis, P. Z., Thompson, E. A., Geiger, X. J. & Storz, P., Aug 23 2013, In : Breast Cancer Research. 15, 2, R66.

Research output: Contribution to journalArticle

Epigenomics
Protein Kinases
decitabine
Breast Neoplasms
Neoplasm Metastasis
10 Citations (Scopus)

Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) syx

Ngok, S. P., Geyer, R., Kourtidis, A., Storz, P. & Anastasiadis, P. Z., Mar 1 2013, In : Journal of Biological Chemistry. 288, 9, p. 6640-6650 11 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
14-3-3 Proteins
Guanine Nucleotide Exchange Factors
Phosphorylation
Protein Binding
21 Citations (Scopus)

Protein kinase D1-mediated phosphorylations regulate Vasodilator-stimulated phosphoprotein (VASP) localization and cell migration

Döppler, H. R., Bastea, L. I., Lewis-Tuffin, L. J., Anastasiadis, P. Z. & Storz, P., Aug 23 2013, In : Journal of Biological Chemistry. 288, 34, p. 24382-24393 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Protein Kinases
Cell Movement
Focal Adhesions
Actins
8 Citations (Scopus)

Protein kinase D isoforms: New targets for therapy in invasive breast cancers?

Borges, S. & Storz, P., Aug 2013, In : Expert Review of Anticancer Therapy. 13, 8, p. 895-898 4 p.

Research output: Contribution to journalArticle

Neoplasm Invasiveness
Molecular Targeted Therapy
Antineoplastic Agents
Protein Kinase C
Isoenzymes
13 Citations (Scopus)

Protein kinase D-mediated phosphorylation at Ser99 regulates localization of p21-activated kinase 4

Bastea, L. I., Döppler, H., Pearce, S. E., Durand, N., Spratley, S. J. & Storz, P., Oct 15 2013, In : Biochemical Journal. 455, 2, p. 251-260 10 p.

Research output: Contribution to journalArticle

p21-Activated Kinases
Phosphorylation
Actin Depolymerizing Factors
Phosphotransferases
Protein Kinases
20 Citations (Scopus)

Regulation of VASP by phosphorylation Consequences for cell migration

Döppler, H. & Storz, P., Nov 2013, In : Cell Adhesion and Migration. 7, 6, p. 482-486 5 p.

Research output: Contribution to journalArticle

Cell Movement
Phosphorylation
Phosphotransferases
Pseudopodia
Focal Adhesions
14 Citations (Scopus)

Targeting the alternative NF-κB pathway in pancreatic cancer: A new direction for therapy?

Storz, P., May 2013, In : Expert Review of Anticancer Therapy. 13, 5, p. 501-504 4 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 2
Molecular Targeted Therapy
NF-kappa B
Drug Design
Delayed Diagnosis
2012
261 Citations (Scopus)

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

Ardito, C. M., Grüner, B. M., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P. K., DelGiorno, K. E., Carpenter, E. S., Halbrook, C. J., Hall, J. C., Pal, D., Briel, T., Herner, A., Trajkovic-Arsic, M., Sipos, B., Liou, G. Y., Storz, P., Murray, N. R., Threadgill, D. W., Sibilia, M. & 6 others, Washington, M. K., Wilson, C. L., Schmid, R. M., Raines, E. W., Crawford, H. C. & Siveke, J. T., Sep 11 2012, In : Cancer Cell. 22, 3, p. 304-317 14 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Carcinogenesis
Adenocarcinoma
Mitogen-Activated Protein Kinase Kinases
Oncogenes
19 Citations (Scopus)

Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: A paradigm shift that impacts current therapeutic strategies

Marlow, L. A., von Roemeling, C. A., Cooper, S. J., Zhang, Y., Rohl, S. D., Arora, S., Gonzales, I. M., Azorsa, D. O., Reddi, H. V., Tun, H. W., Dö ppler, H. R., Storz, P., Smallridge, R. C. & Copland, J. A. III., 2012, In : Journal of Cell Science. 125, 18, p. 4253-4263 11 p.

Research output: Contribution to journalArticle

Cyclin A1
Neoplasms
Therapeutics
Cell Cycle
Up-Regulation
6 Citations (Scopus)

Oxidative stress in cancer

Storz, P., Sep 1 2012, Oxidative Stress and Redox Regulation. Springer Netherlands, Vol. 9789400757875. p. 427-447 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Oxidative stress
Tumors
Oxidative Stress
Reactive Oxygen Species
Neoplasms
29 Citations (Scopus)

Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex

Bastea, L. I., Döppler, H., Balogun, B. & Storz, P., Jan 20 2012, In : PLoS One. 7, 1, e30459.

Research output: Contribution to journalArticle

cadherins
Cadherins
protein kinases
Protein Kinases
Phosphorylation
26 Citations (Scopus)

Protein kinase D1 mediates anchorage-dependent and -independent growth of tumor cells via the zinc finger transcription factor snail

Eiseler, T., Köhler, C., Nimmagadda, S. C., Jamali, A., Funk, N., Joodi, G., Storz, P. & Seufferlein, T., Sep 21 2012, In : Journal of Biological Chemistry. 287, 39, p. 32367-32380 14 p.

Research output: Contribution to journalArticle

Zinc Fingers
Protein Kinases
Zinc
Tumors
Transcription Factors
2 Citations (Scopus)

Protein kinase D signaling in cancer

Storz, P., May 1 2012, Cell Signaling & Molecular Targets in Cancer. Springer New York, Vol. 9781461407300. p. 245-271 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neoplasms
src-Family Kinases
Protein-Serine-Threonine Kinases
Diglycerides
Phorbol Esters
57 Citations (Scopus)

VEGF and angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx

Ngok, S. P., Geyer, R., Liu, M., Kourtidis, A., Agrawal, S., Wu, C., Seerapu, H. R., Lewis-Tuffin, L. J., Moodie, K. L., Huveldt, D., Marx, R., Baraban, J. M., Storz, P., Horowitz, A. & Anastasiadis, P. Z., Dec 2012, In : Journal of Cell Biology. 199, 7, p. 1103-1115 13 p.

Research output: Contribution to journalArticle

Angiopoietin-1
Intercellular Junctions
Vascular Endothelial Growth Factor A
Endothelial Cells
Guanine Nucleotide Exchange Factors
2011
177 Citations (Scopus)

Forkhead homeobox type O transcription factors in the responses to oxidative stress

Storz, P., Feb 15 2011, In : Antioxidants and Redox Signaling. 14, 4, p. 593-605 13 p.

Research output: Contribution to journalArticle

Oxidative stress
Homeobox Genes
Reactive Oxygen Species
Oxidative Stress
Transcription Factors
50 Citations (Scopus)

Protein kinase D regulates cofilin activity through p21-activated kinase 4

Spratley, S. J., Bastea, L. I., Döppler, H., Mizuno, K. & Storz, P., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 34254-34261 8 p.

Research output: Contribution to journalArticle

p21-Activated Kinases
Actin Depolymerizing Factors
Phosphorylation
Actins
Lim Kinases
2010
981 Citations (Scopus)

Reactive oxygen species in cancer

Liou, G. Y. & Storz, P., 2010, In : Free Radical Research. 44, 5, p. 479-496 18 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Tumors
Neoplasms
Cells
Antioxidants
2009
79 Citations (Scopus)

FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases

Storz, P., Döppler, H., Copland, J. A. III., Simpson, K. J. & Toker, A., Sep 2009, In : Molecular and Cellular Biology. 29, 18, p. 4906-4917 12 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Neoplasms
Forkhead Transcription Factors
Matrix Metalloproteinase 9
Starvation
45 Citations (Scopus)

Loss of cell-cell contacts induces NF-κB via RhoA-mediated activation of protein kinase D1

Cowell, C. F., Yan, I. K., Eiseler, T., Leightner, A. C., Döppler, H. & Storz, P., Mar 1 2009, In : Journal of Cellular Biochemistry. 106, 4, p. 714-728 15 p.

Research output: Contribution to journalArticle

Protein Kinases
Chemical activation
Cytology
rho GTP-Binding Proteins
src-Family Kinases
35 Citations (Scopus)

Mitochondrial diacylglycerol initiates protein-kinase-D1-mediated ROS signaling

Cowell, C. F., Döppler, H., Yan, I. K., Hausser, A., Umazawa, Y. & Storz, P., Apr 1 2009, In : Journal of Cell Science. 122, 7, p. 919-928 10 p.

Research output: Contribution to journalArticle

Diglycerides
Protein Kinases
Reactive Oxygen Species
Mitochondria
Protein-Serine-Threonine Kinases
11 Citations (Scopus)

Protein kinase D1: A novel regulator of actin-driven directed cell migration

Storz, P., Jul 1 2009, In : Cell Cycle. 8, 13, p. 1975-1976 2 p.

Research output: Contribution to journalArticle

Actin Depolymerizing Factors
Protein Kinases
Cell Movement
Actins
162 Citations (Scopus)

Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot

Eiseler, T., Döppler, H., Yan, I. K., Kitatani, K., Mizuno, K. & Storz, P., 2009, In : Nature Cell Biology. 11, 5, p. 545-556 12 p.

Research output: Contribution to journalArticle

Actin Depolymerizing Factors
Protein Kinases
Cell Movement
Actins
Pseudopodia
99 Citations (Scopus)

Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion

Eiseler, T., Döppler, H., Yan, I. K., Goodison, S. & Storz, P., Feb 25 2009, In : Breast Cancer Research. 11, 1, R13.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Protein Kinases
Breast Neoplasms
Cell Line
Aptitude
2008
36 Citations (Scopus)

Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association

Watkins, J. L., Lewandowski, K. T., Meek, S. E. M., Storz, P., Toker, A. & Piwnica-Worms, H., Nov 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 47, p. 18378-18383 6 p.

Research output: Contribution to journalArticle

Phosphotransferases
Phosphorylation
Serine
Membranes
Acetates
2007
54 Citations (Scopus)

A novel tyrosine phosphorylation site in protein kinase D contributes to oxidative stress-mediated activation

Döppler, H. & Storz, P., Nov 2 2007, In : Journal of Biological Chemistry. 282, 44, p. 31873-31881 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Oxidative stress
Protein Kinases
Tyrosine
Oxidative Stress
80 Citations (Scopus)

Mitochondrial ROS - radical detoxification, mediated by protein kinase D

Storz, P., Jan 2007, In : Trends in Cell Biology. 17, 1, p. 13-18 6 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Mitochondria
Oxidative Stress
Protein-Serine-Threonine Kinases
Electron Transport
2006
74 Citations (Scopus)
Mitochondria
Reactive Oxygen Species
Antioxidants
Aging of materials
Proteins
2005
51 Citations (Scopus)

Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo

Kraft, S., Fleming, T., Billingsley, J. M., Lin, S. Y., Jouvin, M. H., Storz, P. & Kinet, J. P., Feb 7 2005, In : Journal of Experimental Medicine. 201, 3, p. 385-396 12 p.

Research output: Contribution to journalArticle

Immunoglobulin E
Extracellular Matrix Proteins
Anti-Idiotypic Antibodies
Hypersensitivity
Mast Cells
130 Citations (Scopus)

A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D

Döppler, H., Storz, P., Li, J., Comb, M. J. & Toker, A., Apr 15 2005, In : Journal of Biological Chemistry. 280, 15, p. 15013-15019 7 p.

Research output: Contribution to journalArticle

Phospho-Specific Antibodies
Substrates
Antibodies
Protein Kinases
Cell signaling
45 Citations (Scopus)

Functional dichotomy of A20 in apoptotic and necrotic cell death

Storz, P., Döppler, H., Ferran, C., Grey, S. T. & Toker, A., Apr 1 2005, In : Biochemical Journal. 387, 1, p. 47-55 9 p.

Research output: Contribution to journalArticle

Oxidative stress
Cell death
Oxidative Stress
Cell Death
Reactive Oxygen Species
156 Citations (Scopus)

Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species

Storz, P., Döppler, H. & Toker, A., Oct 2005, In : Molecular and Cellular Biology. 25, 19, p. 8520-8530 11 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Mitochondria
Superoxide Dismutase
Transcription Factors
Protein-Serine-Threonine Kinases
237 Citations (Scopus)

Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex

Hausser, A., Storz, P., Märtens, S., Link, G., Toker, A. & Pfizenmaier, K., Sep 2005, In : Nature Cell Biology. 7, 9, p. 880-886 7 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Golgi Apparatus
trans-Golgi Network
Protein Transport
Protein Isoforms
83 Citations (Scopus)

Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor

Zhang, W., Zheng, S., Storz, P. & Min, W., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 19036-19044 9 p.

Research output: Contribution to journalArticle

MAP Kinase Kinase Kinase 5
JNK Mitogen-Activated Protein Kinases
Tumor Necrosis Factor-alpha
Chemical activation
14-3-3 Proteins
558 Citations (Scopus)

Reactive oxygen species in tumor progression

Storz, P., 2005, In : Frontiers in Bioscience. 10, 2, p. 1881-1896 16 p.

Research output: Contribution to journalArticle

Tumors
Reactive Oxygen Species
Neoplasms
Cells
Antioxidants
2004
90 Citations (Scopus)

Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor κB

Storz, P., Döppler, H. & Toker, A., Oct 2004, In : Molecular Pharmacology. 66, 4, p. 870-879 10 p.

Research output: Contribution to journalArticle

Phosphorylation
Oxidative Stress
Protein Kinase C
Phosphotransferases
Antioxidants
254 Citations (Scopus)

A rapid method for determining protein kinase phosphorylation specificity.

Hutti, J. E., Jarrell, E. T., Chang, J. D., Abbott, D. W., Storz, P., Toker, A., Cantley, L. C. & Turk, B. E., Oct 2004, In : Nat Methods. 1, 1, p. 27-29 3 p.

Research output: Contribution to journalArticle

Phosphorylation
Protein Kinases
Substrates
Peptide Library
Peptides
64 Citations (Scopus)

Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1

Wang, Y., Schattenberg, J. M., Rigoli, R. M., Storz, P. & Czaja, M. J., Jul 23 2004, In : Journal of Biological Chemistry. 279, 30, p. 31089-31097 9 p.

Research output: Contribution to journalArticle

Vitamin K 3
Oxidative stress
Transcription Factor AP-1
Protein Kinase C
Hepatocytes
170 Citations (Scopus)

Protein Kinase Cδ Selectively Regulates Protein Kinase D-Dependent Activation of NF-κB in Oxidative Stress Signaling

Storz, P., Döppler, H. & Toker, A., Apr 2004, In : Molecular and Cellular Biology. 24, 7, p. 2614-2626 13 p.

Research output: Contribution to journalArticle

Protein Kinase C
Oxidative Stress
Phosphorylation
src-Family Kinases
protein kinase D
2003
46 Citations (Scopus)

NF-kappaB signaling--an alternate pathway for oxidative stress responses.

Storz, P. & Toker, A., Jan 2003, In : Cell cycle (Georgetown, Tex.). 2, 1, p. 9-10 2 p.

Research output: Contribution to journalArticle

I-kappa B Proteins
NF-kappa B
Eukaryotic Cells
Protein Kinase C
Signal Transduction
233 Citations (Scopus)

Protein kinase D mediates a stress-induced NF-κB activation and survival pathway

Storz, P. & Toker, A., Jan 2 2003, In : EMBO Journal. 22, 1, p. 109-120 12 p.

Research output: Contribution to journalArticle

Oxidative stress
Oxidative Stress
Chemical activation
Phosphorylation
Protein-Tyrosine Kinases
95 Citations (Scopus)

Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation

Storz, P., Döppler, H., Johannes, F. J. & Toker, A., May 16 2003, In : Journal of Biological Chemistry. 278, 20, p. 17969-17976 8 p.

Research output: Contribution to journalArticle

Phosphorylation
Protein-Tyrosine Kinases
Tyrosine
Chemical activation
Protein Kinase C
2002
101 Citations (Scopus)
3-Phosphoinositide-Dependent Protein Kinases
Phosphatidylinositol 3-Kinases
Phosphotransferases
1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
102 Citations (Scopus)

Protein kinase C (PKC)η-mediated PKCμ activation modulates ERK and JNK signal pathways

Brändlin, I., Hübner, S., Eiseler, T., Martinez-Moya, M., Horschinek, A., Hausser, A., Link, G., Rupp, S., Storz, P., Pfizenmaier, K. & Johannes, F. J., Feb 22 2002, In : Journal of Biological Chemistry. 277, 8, p. 6490-6496 7 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Protein Kinase C
Signal Transduction
Chemical activation
Phosphorylation
2001
53 Citations (Scopus)

Protein kinase C μ selectively activates the mitogen-activated protein kinase (MAPK) p42 pathway

Hausser, A., Storz, P., Hübner, S., Braendlin, I., Martinez-Moya, M., Link, G. & Johannes, F. J., Mar 9 2001, In : FEBS Letters. 492, 1-2, p. 39-44 6 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 1
Protein Kinase C
Serum Response Element
Mitogen-Activated Protein Kinases
Chemical activation
2000
72 Citations (Scopus)

Protein kinase C μ is regulated by the multifunctional chaperon protein p32

Storz, P., Hausser, A., Link, G., Dedio, J., Ghebrehiwet, B., Pfizenmaier, K. & Johannes, F. J., Aug 11 2000, In : Journal of Biological Chemistry. 275, 32, p. 24601-24607 7 p.

Research output: Contribution to journalArticle

Protein Kinase C
Proteins
Phosphotransferases
Assays
complement 1q receptor
11 Citations (Scopus)
Receptor Protein-Tyrosine Kinases
Signal Transduction
Down-Regulation
Cytostatic Agents
Somatomedins
1999
17 Citations (Scopus)

A cellular reporter assay to monitor insulin receptor kinase activity based on STAT 5-dependent luciferase gene expression

Storz, P., Döppler, H., Horn-Müller, J., Groner, B., Pfizenmaier, K. & Müller, G., Dec 1 1999, In : Analytical Biochemistry. 276, 1, p. 97-104 8 p.

Research output: Contribution to journalArticle

Insulin Receptor
Luciferases
Gene expression
STAT5 Transcription Factor
Assays
39 Citations (Scopus)

Bruton's tyrosine kinase (Btk) associates with protein kinase C μ

Johannes, F. J., Hausser, A., Storz, P., Truckenmüller, L., Link, G., Kawakami, T. & Pfizenmaier, K., Nov 12 1999, In : FEBS Letters. 461, 1-2, p. 68-72 5 p.

Research output: Contribution to journalArticle

Protein Kinase C
B-Lymphocytes
Cells
Antigen Receptors
Agammaglobulinaemia tyrosine kinase
88 Citations (Scopus)
Proto-Oncogene Proteins c-akt
Palmitates
Muscle Cells
Muscle
Insulin Resistance
31 Citations (Scopus)

Insulin selectively activates STAT5b, but not STAT5a, via a JAK2- independent signalling pathway in Kym-1 rhabdomyosarcoma cells

Storz, P., Döppler, H., Pfizenmaier, K. & Müller, G., Dec 31 1999, In : FEBS Letters. 464, 3, p. 159-163 5 p.

Research output: Contribution to journalArticle

Phosphorylation
Insulin Receptor
Janus Kinases
Phosphotransferases
Chemical activation