• 11416 Citations
  • 45 Scopus h-Index
19952020

Research output per year

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Research Output

  • 11416 Citations
  • 45 Scopus h-Index
  • 85 Article
  • 10 Review article
  • 2 Chapter
  • 1 Letter
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Article

14-3-3 proteins reduce cell-to-cell transfer and propagation of pathogenic α-synuclein

Wang, B., Underwood, R., Kamath, A., Britain, C., McFerrin, M. B., McLean, P. J., Volpicelli-Daley, L. A., Whitaker, R. H., Placzek, W. J., Becker, K., Ma, J. & Yacoubian, T. A., Sep 19 2018, In : Journal of Neuroscience. 38, 38, p. 8211-8232 22 p.

Research output: Contribution to journalArticle

9 Scopus citations

A close association of torsinA and α-synuclein in lewy bodies: A fluorescence resonance energy transfer study

Sharma, N., Hewett, J., Ozelius, L. J., Ramesh, V., McLean, P. J., Breakefield, X. O. & Hyman, B. T., Jul 2001, In : American Journal of Pathology. 159, 1, p. 339-344 6 p.

Research output: Contribution to journalArticle

92 Scopus citations

Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway

Klucken, J., Poehler, A. M., Ebrahimi-Fakhari, D., Schneider, J., Nuber, S., Rockenstein, E., Schlötzer-Schrehardt, U., Hyman, B. T., McLean, P. J., Masliah, E. & Winkler, J., May 2012, In : Autophagy. 8, 5, p. 754-766 13 p.

Research output: Contribution to journalArticle

76 Scopus citations

Alpha-synuclein and chaperones in dementia with Lewy bodies

Cantuti-Castelvetri, I., Klucken, J., Ingelsson, M., Ramasamy, K., McLean, P. J., Frosch, M. P., Hyman, B. T. & Standaert, D. G., Dec 1 2005, In : Journal of Neuropathology and Experimental Neurology. 64, 12, p. 1058-1066 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Alpha-synuclein and tau: teammates in neurodegeneration?

Moussaud, S., Jones, D. R., Moussaud-Lamodière, E. L., Delenclos, M., Ross, O. A. & McLean, P. J., 2014, In : Molecular Neurodegeneration. 9, p. 43 1 p.

Research output: Contribution to journalArticle

89 Scopus citations

Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies

Sharma, N., McLean, P. J., Kawamata, H., Irizarry, M. C. & Hyman, B. T., Oct 4 2001, In : Acta neuropathologica. 102, 4, p. 329-334 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Park, J. H., Burgess, J. D., Faroqi, A. H., Demeo, N. N., Fiesel, F. C., Springer, W., Delenclos, M. & McLean, P. J., Jan 13 2020, In : Molecular neurodegeneration. 15, 1, 5.

Research output: Contribution to journalArticle

Open Access

A minimal promoter for the GABA(A) receptor α6-subunit gene controls tissue specificity

McLean, P. J., Shpektor, D., Bandyopadhyay, S., Russek, S. J. & Farb, D. H., May 3 2000, In : Journal of neurochemistry. 74, 5, p. 1858-1869 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
26 Scopus citations

APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

Zhao, N., Attrebi, O. N., Ren, Y., Qiao, W., Sonustun, B., Martens, Y. A., Meneses, A. D., Li, F., Shue, F., Zheng, J., van Ingelgom, A. J., Davis, M. D., Kurti, A., Knight, J. A., Linares, C., Chen, Y., Delenclos, M., Liu, C. C., Fryer, J. D., Asmann, Y. W. & 4 others, McLean, P. J., Dickson, D. W., Ross, O. A. & Bu, G., Feb 5 2020, In : Science translational medicine. 12, 529, eaay1809.

Research output: Contribution to journalArticle

4 Scopus citations

A rapid, semi-quantitative assay to screen for modulators of Alpha-synuclein oligomerization ex vivo

Delenclos, M., Trendafilova, T., Jones, D. R., Moussaud, S., Baine, A. M., Yue, M., Hirst, W. D. & McLean, P. J., 2016, In : Frontiers in Neuroscience. 9, JAN, 511.

Research output: Contribution to journalArticle

3 Scopus citations

A single amino acid substitution differentiates Hsp70-dependent effects on α-synuclein degradation and toxicity

Klucken, J., Shin, Y., Hyman, B. T. & McLean, P. J., Dec 3 2004, In : Biochemical and Biophysical Research Communications. 325, 1, p. 367-373 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Aspartate mutations in presenilin and γ-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch1 signaling

Berezovska, O., Jack, C., McLean, P., Aster, J. C., Hicks, C., Xia, W., Wolfe, M. S., Kimberly, W. T., Weinmaster, G., Selkoe, D. J. & Hyman, B. T., Aug 7 2000, In : Journal of neurochemistry. 75, 2, p. 583-593 11 p.

Research output: Contribution to journalArticle

110 Scopus citations

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice

Cai, W., Feng, D., Schwarzschild, M. A., McLean, P. J. & Chen, X., Mar 1 2018, In : EBioMedicine. 29, p. 13-22 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Biomarkers in Parkinson's disease: Advances and strategies

Delenclos, M., Jones, D. R., McLean, P. J. & Uitti, R. J., Jan 1 2016, In : Parkinsonism and Related Disorders. 22, p. S106-S110

Research output: Contribution to journalArticle

49 Scopus citations

Brain-permeable small-molecule inhibitors of Hsp90 prevent α-synuclein oligomer formation and rescue α-synuclein-induced toxicity

Putcha, P., Danzer, K. M., Kranich, L. R., Scott, A., Silinski, M., Mabbett, S., Hicks, C. D., Veal, J. M., Steed, P. M., Hyman, B. T. & McLean, P. J., Mar 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 3, p. 849-857 9 p.

Research output: Contribution to journalArticle

109 Scopus citations

Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway

Giaime, E., Sunyach, C., Herrant, M., Grosso, S., Auberge, P., McLean, P. J., Checler, F. & Alves Da Costa, C., Apr 28 2006, In : Journal of Biological Chemistry. 281, 17, p. 11515-11522 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Characterization of oligomer formation of amyloid-β peptide using a split-luciferase complementation assay

Hashimoto, T., Adams, K. W., Fan, Z., McLean, P. J. & Hyman, B. T., Aug 5 2011, In : Journal of Biological Chemistry. 286, 31, p. 27081-27091 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

CHIP targets toxic α-synuclein oligomers for degradation

Tetzlaff, J. E., Putcha, P., Outeiro, T. F., Ivanov, A., Berezovska, O., Hyman, B. T. & McLean, P. J., Jun 27 2008, In : Journal of Biological Chemistry. 283, 26, p. 17962-17968 7 p.

Research output: Contribution to journalArticle

109 Scopus citations

Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss

McFarland, N. R., Dimant, H., Kibuuka, L., Ebrahimi-Fakhari, D., Desjardins, C. A., Danzer, K. M., Danzer, M., Fan, Z., Schwarzschild, M. A., Hirst, W. & McLean, P. J., Jan 20 2014, In : PloS one. 9, 1, e86048.

Research output: Contribution to journalArticle

22 Scopus citations

Clinical and biochemical correlates of insoluble α-synuclein in dementia with Lewy bodies

Klucken, J., Ingelsson, M., Shin, Y., Irizarry, M. C., Hedley-Whyte, E. T., Frosch, M. P., Growdon, J. H., McLean, P. J. & Hyman, B. T., Feb 1 2006, In : Acta neuropathologica. 111, 2, p. 101-108 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system

McFarland, N. R., Lee, J. S., Hyman, B. T. & McLean, P. J., May 1 2009, In : Journal of neurochemistry. 109, 3, p. 838-845 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: A role for the novel interaction of alpha-synuclein and presenilin 1 in disease

Winslow, A. R., Moussaud, S., Zhu, L., Post, K. L., Dickson, D. W., Berezovska, O. & McLean, P. J., Jul 2014, In : Brain. 137, 7, p. 1958-1970 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Converse modulation of toxic α-synuclein oligomers in living cells by N′-benzylidene-benzohydrazide derivates and ferric iron

Hillmer, A. S., Putcha, P., Levin, J., Högen, T., Hyman, B. T., Kretzschmar, H., McLean, P. J. & Giese, A., Jan 1 2010, In : Biochemical and Biophysical Research Communications. 391, 1, p. 461-466 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

Sun, J., Carlson-Stevermer, J., Das, U., Shen, M., Delenclos, M., Snead, A. M., Koo, S. Y., Wang, L., Qiao, D., Loi, J., Petersen, A. J., Stockton, M., Bhattacharyya, A., Jones, M. V., Zhao, X., McLean, P. J., Sproul, A. A., Saha, K. & Roy, S., Dec 1 2019, In : Nature Communications. 10, 1, 53.

Research output: Contribution to journalArticle

8 Scopus citations

Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

Spires, T. L., Meyer-Luehmann, M., Stern, E. A., McLean, P. J., Skoch, J., Nguyen, P. T., Bacskai, B. J. & Hyman, B. T., Aug 3 2005, In : Journal of Neuroscience. 25, 31, p. 7278-7287 10 p.

Research output: Contribution to journalArticle

414 Scopus citations

Detection of novel intracellular α-synuclein oligomeric species by fluorescence lifetime imaging

Klucken, J., Outeiro, T. F., Nguyen, P., McLean, P. J. & Hyman, B. T., Oct 1 2006, In : FASEB Journal. 20, 12, p. 2050-2057 8 p.

Research output: Contribution to journalArticle

64 Scopus citations

Development and screening of contrast agents for in vivo imaging of Parkinson's disease

Neal, K. L., Shakerdge, N. B., Hou, S. S., Klunk, W. E., Mathis, C. A., Nesterov, E. E., Swager, T. M., McLean, P. J. & Bacskai, B. J., Oct 1 2013, In : Molecular Imaging and Biology. 15, 5, p. 585-595 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Direct detection of alpha synuclein oligomers in vivo

Dimant, H., Kalia, S. K., Kalia, L. V., Zhu, L. N., Kibuuka, L., Ebrahimi-Fakhari, D., McFarland, N. R., Fan, Z., Hyman, B. T. & McLean, P. J., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 6.

Research output: Contribution to journalArticle

31 Scopus citations

Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

Mollenhauer, B., Cullen, V., Kahn, I., Krastins, B., Outeiro, T. F., Pepivani, I., Ng, J., Schulz-Schaeffer, W., Kretzschmar, H. A., McLean, P. J., Trenkwalder, C., Sarracino, D. A., VonSattel, J. P., Locascio, J. J., El-Agnaf, O. M. A. & Schlossmacher, M. G., Oct 1 2008, In : Experimental Neurology. 213, 2, p. 315-325 11 p.

Research output: Contribution to journalArticle

276 Scopus citations

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: Implications for PD therapeutics

Dimant, H., Zhu, L., Kibuuka, L. N., Fan, Z., Hyman, B. T. & McLean, P. J., Mar 24 2014, In : PloS one. 9, 3, e92098.

Research output: Contribution to journalArticle

4 Scopus citations

Distinct roles in vivo for the Ubiquitin-Proteasome system and the Autophagy-Lysosomal Pathway in the Degradation of α-Synuclein

Ebrahimi-Fakhari, D., Cantuti-Castelvetri, I., Fan, Z., Rockenstein, E., Masliah, E., Hyman, B. T., McLean, P. J. & Unni, V. K., Oct 12 2011, In : Journal of Neuroscience. 31, 41, p. 14508-14520 13 p.

Research output: Contribution to journalArticle

225 Scopus citations

DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients

Lorenzo-Betancor, O., Ogaki, K., Soto-Ortolaza, A. I., Labbe, C., Walton, R. L., Strongosky, A. J., Van Gerpen, J. A., Uitti, R. J., McLean, P. J., Springer, W., Siuda, J., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K., Mccarthy, A., Lynch, T., Puschmann, A., Rektorova, I., Sanotsky, Y. & 10 others, Vilariño-Güell, C., Farrer, M. J., Ferman, T. J., Boeve, B. F., Petersen, R. C., Parisi, J. E., Graff Radford, N. R., Dickson, D. W., Wszolek, Z. K. & Ross, O. A., Sep 1 2015, In : European Journal of Neurology. 22, 9, p. 1323-1325 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

Dopamine-induced conformational changes in alpha-synuclein

Outerio, T. F., Klucken, J., Bercury, K., Tetzlaff, J., Putcha, P., Oliveira, L. M. A., Quintas, A., McLean, P. J. & Hyman, B. T., Sep 4 2009, In : PloS one. 4, 9, e6906.

Research output: Contribution to journalArticle

45 Scopus citations

Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra

St Martin, J. L., Klucken, J., Outeiro, T. F., Nguyen, P., Keller-McGandy, C., Cantuti-Castelvetri, I., Grammatopoulos, T. N., Standaert, D. G., Hyman, B. T. & McLean, P. J., Mar 1 2007, In : Journal of neurochemistry. 100, 6, p. 1449-1457 9 p.

Research output: Contribution to journalArticle

116 Scopus citations

Drug targets from genetics: Alpha-synuclein

Danzer, K. M. & Mclean, P. J., Sep 1 2011, In : CNS and Neurological Disorders - Drug Targets. 10, 6, p. 712-723 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Exosomal cell-to-cell transmission of alpha synuclein oligomers

Danzer, K. M., Kranich, L. R., Ruf, W. P., Cagsal-Getkin, O., Winslow, A. R., Zhu, L., Vanderburg, C. R. & McLean, P. J., Aug 28 2012, In : Molecular neurodegeneration. 7, 1, 42.

Research output: Contribution to journalArticle

376 Scopus citations

Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction

Gan, M., Moussaud, S., Jiang, P. & McLean, P. J., Feb 1 2015, In : Neurobiology of aging. 36, 2, p. 1209-1220 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Formation of toxic oligomeric α-synuclein species in living cells

Outeiro, T. F., Putcha, P., Tetzlaff, J. E., Spoelgen, R., Koker, M., Carvalho, F., Hyman, B. T. & McLean, P. J., Apr 2 2008, In : PloS one. 3, 4, e1867.

Research output: Contribution to journalArticle

272 Scopus citations

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

Mazzulli, J. R., Xu, Y. H., Sun, Y., Knight, A. L., McLean, P. J., Caldwell, G. A., Sidransky, E., Grabowski, G. A. & Krainc, D., Jul 8 2011, In : Cell. 146, 1, p. 37-52 16 p.

Research output: Contribution to journalArticle

663 Scopus citations

Geldanamycin induces Hsp70 and prevents α-synuclein aggregation and toxicity in vitro

McLean, P. J., Klucken, J., Shin, Y. & Hyman, B. T., Aug 27 2004, In : Biochemical and Biophysical Research Communications. 321, 3, p. 665-669 5 p.

Research output: Contribution to journalArticle

129 Scopus citations

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

Danzer, K. M., Ruf, W. P., Putcha, P., Joyner, D., Hashimoto, T., Glabe, C., Hyman, B. T. & McLean, P. J., Jan 1 2011, In : FASEB Journal. 25, 1, p. 326-336 11 p.

Research output: Contribution to journalArticle

191 Scopus citations

Histones facilitate α-synuclein aggregation during neuronal apoptosis

Jiang, P., Gan, M., Yen, S. H., McLean, P. J. & Dickson, D. W., Dec 21 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-12 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Hsp70 reduces α-synuclein aggregation and toxicity

Klucken, J., Shin, Y., Masliah, E., Hyman, B. T. & McLean, P. J., Jun 11 2004, In : Journal of Biological Chemistry. 279, 24, p. 25497-25502 6 p.

Research output: Contribution to journalArticle

355 Scopus citations

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

Jiang, P., Gan, M., Yen, S. H., McLean, P. J. & Dickson, D. W., Dec 1 2017, In : Scientific Reports. 7, 1, 7690.

Research output: Contribution to journalArticle

18 Scopus citations

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease

Grozdanov, V., Bousset, L., Hoffmeister, M., Bliederhaeuser, C., Meier, C., Madiona, K., Pieri, L., Kiechle, M., McLean, P. J., Kassubek, J., Behrends, C., Ludolph, A. C., Weishaupt, J. H., Melki, R. & Danzer, K. M., Oct 1 2019, In : Annals of neurology. 86, 4, p. 593-606 14 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Interaction of α-synuclein and synphilin-1: Effect of Parkinson's disease-associated mutations

Kawamata, H., McLean, P. J., Sharma, N. & Hyman, B. T., Jun 4 2001, In : Journal of neurochemistry. 77, 3, p. 929-934 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Intracellular formation of α-synuclein oligomers and the effect of heat shock protein 70 characterized by confocal single particle spectroscopy

Levin, J., Hillmer, A. S., Högen, T., McLean, P. J. & Giese, A., Aug 12 2016, In : Biochemical and Biophysical Research Communications. 477, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Investigation of endocytic pathways for the internalization of exosome-associated oligomeric alpha-synuclein

Delenclos, M., Trendafilova, T., Mahesh, D., Baine, A. M., Moussaud, S., Yan, I. K., Patel, T. C. & McLean, P. J., Mar 30 2017, In : Frontiers in Neuroscience. 11, MAR, 172.

Research output: Contribution to journalArticle

24 Scopus citations

In vivo imaging of α-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility

Unni, V. K., Weissman, T. A., Rockenstein, E., Masliah, E., McLean, P. J. & Hyman, B. T., Sep 17 2010, In : PloS one. 5, 5, e10589.

Research output: Contribution to journalArticle

32 Scopus citations