• 11651 Citations
  • 46 Scopus h-Index
19952020

Research output per year

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Research Output

  • 11651 Citations
  • 46 Scopus h-Index
  • 85 Article
  • 10 Review article
  • 2 Chapter
  • 1 Letter
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Article
2020

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Park, J. H., Burgess, J. D., Faroqi, A. H., Demeo, N. N., Fiesel, F. C., Springer, W., Delenclos, M. & McLean, P. J., Jan 13 2020, In : Molecular neurodegeneration. 15, 1, 5.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

Zhao, N., Attrebi, O. N., Ren, Y., Qiao, W., Sonustun, B., Martens, Y. A., Meneses, A. D., Li, F., Shue, F., Zheng, J., van Ingelgom, A. J., Davis, M. D., Kurti, A., Knight, J. A., Linares, C., Chen, Y., Delenclos, M., Liu, C. C., Fryer, J. D., Asmann, Y. W. & 4 others, McLean, P. J., Dickson, D. W., Ross, O. A. & Bu, G., Feb 5 2020, In : Science translational medicine. 12, 529, eaay1809.

Research output: Contribution to journalArticle

7 Scopus citations
2019

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

Sun, J., Carlson-Stevermer, J., Das, U., Shen, M., Delenclos, M., Snead, A. M., Koo, S. Y., Wang, L., Qiao, D., Loi, J., Petersen, A. J., Stockton, M., Bhattacharyya, A., Jones, M. V., Zhao, X., McLean, P. J., Sproul, A. A., Saha, K. & Roy, S., Dec 1 2019, In : Nature Communications. 10, 1, 53.

Research output: Contribution to journalArticle

9 Scopus citations

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease

Grozdanov, V., Bousset, L., Hoffmeister, M., Bliederhaeuser, C., Meier, C., Madiona, K., Pieri, L., Kiechle, M., McLean, P. J., Kassubek, J., Behrends, C., Ludolph, A. C., Weishaupt, J. H., Melki, R. & Danzer, K. M., Oct 1 2019, In : Annals of neurology. 86, 4, p. 593-606 14 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species

Kiechle, M., von Einem, B., Höfs, L., Voehringer, P., Grozdanov, V., Markx, D., Parlato, R., Wiesner, D., Mayer, B., Sakk, O., Baumann, B., Lukassen, S., Liss, B., Ekici, A. B., Ludolph, A. C., Walther, P., Ferger, B., McLean, P. J., Falkenburger, B. H., Weishaupt, J. H. & 1 others, Danzer, K. M., Nov 26 2019, In : Cell reports. 29, 9, p. 2862-2874.e9

Research output: Contribution to journalArticle

Open Access
2018

14-3-3 proteins reduce cell-to-cell transfer and propagation of pathogenic α-synuclein

Wang, B., Underwood, R., Kamath, A., Britain, C., McFerrin, M. B., McLean, P. J., Volpicelli-Daley, L. A., Whitaker, R. H., Placzek, W. J., Becker, K., Ma, J. & Yacoubian, T. A., Sep 19 2018, In : Journal of Neuroscience. 38, 38, p. 8211-8232 22 p.

Research output: Contribution to journalArticle

12 Scopus citations

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice

Cai, W., Feng, D., Schwarzschild, M. A., McLean, P. J. & Chen, X., Mar 1 2018, In : EBioMedicine. 29, p. 13-22 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

Jiang, P., Gan, M., Yen, S. H., McLean, P. J. & Dickson, D. W., Dec 1 2017, In : Scientific Reports. 7, 1, 7690.

Research output: Contribution to journalArticle

18 Scopus citations

Investigation of endocytic pathways for the internalization of exosome-associated oligomeric alpha-synuclein

Delenclos, M., Trendafilova, T., Mahesh, D., Baine, A. M., Moussaud, S., Yan, I. K., Patel, T. & McLean, P. J., Mar 30 2017, In : Frontiers in Neuroscience. 11, MAR, 172.

Research output: Contribution to journalArticle

28 Scopus citations

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

Delenclos, M., Faroqi, A. H., Yue, M., Kurti, A., Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Fryer, J. D. & McLean, P. J., Jun 23 2017, In : Acta Neuropathologica Communications. 5, 1, 1 p.

Research output: Contribution to journalArticle

5 Scopus citations

The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion

von Einem, B., Eschbach, J., Kiechle, M., Wahler, A., Thal, D. R., McLean, P. J., Weishaupt, J. H., Ludolph, A. C., von Arnim, C. A. F. & Danzer, K. M., Jul 1 2017, In : Aging. 9, 7, p. 1677-1697 21 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

A rapid, semi-quantitative assay to screen for modulators of Alpha-synuclein oligomerization ex vivo

Delenclos, M., Trendafilova, T., Jones, D. R., Moussaud, S., Baine, A. M., Yue, M., Hirst, W. D. & McLean, P. J., 2016, In : Frontiers in Neuroscience. 9, JAN, 511.

Research output: Contribution to journalArticle

3 Scopus citations

Biomarkers in Parkinson's disease: Advances and strategies

Delenclos, M., Jones, D. R., McLean, P. J. & Uitti, R. J., Jan 1 2016, In : Parkinsonism and Related Disorders. 22, p. S106-S110

Research output: Contribution to journalArticle

52 Scopus citations

Histones facilitate α-synuclein aggregation during neuronal apoptosis

Jiang, P., Gan, M., Yen, S. H., McLean, P. J. & Dickson, D. W., Dec 21 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-12 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Intracellular formation of α-synuclein oligomers and the effect of heat shock protein 70 characterized by confocal single particle spectroscopy

Levin, J., Hillmer, A. S., Högen, T., McLean, P. J. & Giese, A., Aug 12 2016, In : Biochemical and Biophysical Research Communications. 477, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons

Jiang, P., Gan, M., Yen, S. H., Moussaud, S., McLean, P. J. & Dickson, D. W., Jul 1 2016, In : Acta neuropathologica. 132, 1, p. 77-91 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity

Jarvela, T. S., Lam, H. A., Helwig, M., Lorenzen, N., Otzen, D. E., McLean, P. J., Maidment, N. T. & Lindberg, I., Aug 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. E4708-E4715

Research output: Contribution to journalArticle

12 Scopus citations
2015

DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients

Lorenzo-Betancor, O., Ogaki, K., Soto-Ortolaza, A. I., Labbe, C., Walton, R. L., Strongosky, A. J., Van Gerpen, J. A., Uitti, R. J., McLean, P. J., Springer, W., Siuda, J., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K., Mccarthy, A., Lynch, T., Puschmann, A., Rektorova, I., Sanotsky, Y. & 10 others, Vilariño-Güell, C., Farrer, M. J., Ferman, T. J., Boeve, B. F., Petersen, R. C., Parisi, J. E., Graff Radford, N. R., Dickson, D. W., Wszolek, Z. K. & Ross, O. A., Sep 1 2015, In : European Journal of Neurology. 22, 9, p. 1323-1325 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction

Gan, M., Moussaud, S., Jiang, P. & McLean, P. J., Feb 1 2015, In : Neurobiology of aging. 36, 2, p. 1209-1220 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

Eschbach, J., Von Einem, B., Müller, K., Bayer, H., Scheffold, A., Morrison, B. E., Rudolph, K. L., Thal, D. R., Witting, A., Weydt, P., Otto, M., Fauler, M., Liss, B., McLean, P. J., La Spada, A. R., Ludolph, A. C., Weishaupt, J. H. & Danzer, K. M., Jan 1 2015, In : Annals of neurology. 77, 1, p. 15-32 18 p.

Research output: Contribution to journalArticle

50 Scopus citations

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Yue, M., Hinkle, K. M., Davies, P., Trushina, E. D., Fiesel, F., Christenson, T. A., Schroeder, A. S., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S. J., Beevers, J. E., Milnerwood, A. J., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D. W., Farrer, M. J. & Melrose, H. L., Jun 1 2015, In : Neurobiology of Disease. 78, p. 172-195 24 p.

Research output: Contribution to journalArticle

86 Scopus citations

Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies

Labbé, C., Ogaki, K., Lorenzo-Betancor, O., Soto-Ortolaza, A. I., Walton, R. L., Rayaprolu, S., Fujioka, S., Murray, M. E., Heckman, M. G., Puschmann, A., McCarthy, A., Lynch, T., Siuda, J., Opala, G., Rudzinska, M., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K., Sanotsky, Y., Rektorová, I. & 16 others, McLean, P. J., Rademakers, R. V., Taner, N., Hassan, A., Ahlskog, J. E., Boeve, B. F., Petersen, R. C., Maraganore, D. M., Adler, C. H., Ferman, T. J., Parisi, J. E., Graff Radford, N. R., Uitti, R. J., Wszolek, Z. K., Dickson, D. W. & Ross, O. A., Nov 10 2015, In : Neurology. 85, 19, p. 1680-1686 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies

Moussaud, S., Malany, S., Mehta, A., Vasile, S., Smith, L. H. & McLean, P. J., May 1 2015, In : Expert Opinion on Therapeutic Targets. 19, 5, p. 589-603 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Transmission of soluble and insoluble α-synuclein to mice

Jones, D. R., Delenclos, M., Baine, A. M. T., Deture, M., Murray, M. E., Dickson, D. W. & McLean, P. J., 2015, In : Journal of Neuropathology and Experimental Neurology. 74, 12, p. 1158-1169 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Untangling a Role for Tau in Synucleinopathies

Delenclos, M., Moussaud, S. & McLean, P. J., Nov 15 2015, In : Biological Psychiatry. 78, 10, p. 666-667 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

α-Synuclein interacts with SOD1 and promotes its oligomerization

Helferich, A. M., Ruf, W. P., Grozdanov, V., Freischmidt, A., Feiler, M. S., Zondler, L., Ludolph, A. C., McLean, P. J., Weishaupt, J. H. & Danzer, K. M., Dec 8 2015, In : Molecular Neurodegeneration. 10, 1, 66.

Research output: Contribution to journalArticle

15 Scopus citations
2014

Alpha-synuclein and tau: teammates in neurodegeneration?

Moussaud, S., Jones, D. R., Moussaud-Lamodière, E. L., Delenclos, M., Ross, O. A. & McLean, P. J., 2014, In : Molecular Neurodegeneration. 9, p. 43 1 p.

Research output: Contribution to journalArticle

92 Scopus citations

Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss

McFarland, N. R., Dimant, H., Kibuuka, L., Ebrahimi-Fakhari, D., Desjardins, C. A., Danzer, K. M., Danzer, M., Fan, Z., Schwarzschild, M. A., Hirst, W. & McLean, P. J., Jan 20 2014, In : PloS one. 9, 1, e86048.

Research output: Contribution to journalArticle

22 Scopus citations

Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: A role for the novel interaction of alpha-synuclein and presenilin 1 in disease

Winslow, A. R., Moussaud, S., Zhu, L., Post, K. L., Dickson, D. W., Berezovska, O. & McLean, P. J., Jul 2014, In : Brain. 137, 7, p. 1958-1970 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Direct detection of alpha synuclein oligomers in vivo

Dimant, H., Kalia, S. K., Kalia, L. V., Zhu, L. N., Kibuuka, L., Ebrahimi-Fakhari, D., McFarland, N. R., Fan, Z., Hyman, B. T. & McLean, P. J., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 6.

Research output: Contribution to journalArticle

31 Scopus citations

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: Implications for PD therapeutics

Dimant, H., Zhu, L., Kibuuka, L. N., Fan, Z., Hyman, B. T. & McLean, P. J., Mar 24 2014, In : PloS one. 9, 3, e92098.

Research output: Contribution to journalArticle

5 Scopus citations
15 Scopus citations

α-Synuclein multimers cluster synaptic vesicles and attenuate recycling

Wang, L., Das, U., Scott, D. A., Tang, Y., McLean, P. J. & Roy, S., Oct 6 2014, In : Current Biology. 24, 19, p. 2319-2326 8 p.

Research output: Contribution to journalArticle

109 Scopus citations
2013

Development and screening of contrast agents for in vivo imaging of Parkinson's disease

Neal, K. L., Shakerdge, N. B., Hou, S. S., Klunk, W. E., Mathis, C. A., Nesterov, E. E., Swager, T. M., McLean, P. J. & Bacskai, B. J., Oct 1 2013, In : Molecular Imaging and Biology. 15, 5, p. 585-595 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

α-synuclein oligomers and clinical implications for parkinson disease

Kalia, L. V., Kalia, S. K., McLean, P. J., Lozano, A. M. & Lang, A. E., Feb 1 2013, In : Annals of neurology. 73, 2, p. 155-169 15 p.

Research output: Contribution to journalArticle

184 Scopus citations
2012

Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway

Klucken, J., Poehler, A. M., Ebrahimi-Fakhari, D., Schneider, J., Nuber, S., Rockenstein, E., Schlötzer-Schrehardt, U., Hyman, B. T., McLean, P. J., Masliah, E. & Winkler, J., May 2012, In : Autophagy. 8, 5, p. 754-766 13 p.

Research output: Contribution to journalArticle

77 Scopus citations

Exosomal cell-to-cell transmission of alpha synuclein oligomers

Danzer, K. M., Kranich, L. R., Ruf, W. P., Cagsal-Getkin, O., Winslow, A. R., Zhu, L., Vanderburg, C. R. & McLean, P. J., Aug 28 2012, In : Molecular neurodegeneration. 7, 1, 42.

Research output: Contribution to journalArticle

391 Scopus citations

SIRT1 protects against α-synuclein aggregation by activating molecular chaperones

Donmez, G., Arun, A., Chung, C. Y., Mclean, P. J., Lindquist, S. & Guarente, L., 2012, In : Journal of Neuroscience. 32, 1, p. 124-132 9 p.

Research output: Contribution to journalArticle

129 Scopus citations
2011

Characterization of oligomer formation of amyloid-β peptide using a split-luciferase complementation assay

Hashimoto, T., Adams, K. W., Fan, Z., McLean, P. J. & Hyman, B. T., Aug 5 2011, In : Journal of Biological Chemistry. 286, 31, p. 27081-27091 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Distinct roles in vivo for the Ubiquitin-Proteasome system and the Autophagy-Lysosomal Pathway in the Degradation of α-Synuclein

Ebrahimi-Fakhari, D., Cantuti-Castelvetri, I., Fan, Z., Rockenstein, E., Masliah, E., Hyman, B. T., McLean, P. J. & Unni, V. K., Oct 12 2011, In : Journal of Neuroscience. 31, 41, p. 14508-14520 13 p.

Research output: Contribution to journalArticle

229 Scopus citations

Drug targets from genetics: Alpha-synuclein

Danzer, K. M. & Mclean, P. J., Sep 2011, In : CNS and Neurological Disorders - Drug Targets. 10, 6, p. 712-723 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

Mazzulli, J. R., Xu, Y. H., Sun, Y., Knight, A. L., McLean, P. J., Caldwell, G. A., Sidransky, E., Grabowski, G. A. & Krainc, D., Jul 8 2011, In : Cell. 146, 1, p. 37-52 16 p.

Research output: Contribution to journalArticle

677 Scopus citations

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

Danzer, K. M., Ruf, W. P., Putcha, P., Joyner, D., Hashimoto, T., Glabe, C., Hyman, B. T. & McLean, P. J., Jan 1 2011, In : FASEB Journal. 25, 1, p. 326-336 11 p.

Research output: Contribution to journalArticle

194 Scopus citations

Studying protein degradation pathways in vivo using a cranial window-based approach

Unni, V. K., Ebrahimi-Fakhari, D., Vanderburg, C. R., McLean, P. J. & Hyman, B. T., Mar 1 2011, In : Methods. 53, 3, p. 194-200 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ubiquitinylation of α-synuclein by carboxyl terminus hsp70-interacting protein (chip) is regulated by bcl-2-associated athanogene 5 (bag5)

Kalia, L. V., Kalia, S. K., Chau, H., Lozano, A. M., Hyman, B. T. & McLean, P. J., 2011, In : PloS one. 6, 2, e14695.

Research output: Contribution to journalArticle

81 Scopus citations
2010

Brain-permeable small-molecule inhibitors of Hsp90 prevent α-synuclein oligomer formation and rescue α-synuclein-induced toxicity

Putcha, P., Danzer, K. M., Kranich, L. R., Scott, A., Silinski, M., Mabbett, S., Hicks, C. D., Veal, J. M., Steed, P. M., Hyman, B. T. & McLean, P. J., Mar 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 3, p. 849-857 9 p.

Research output: Contribution to journalArticle

110 Scopus citations

Converse modulation of toxic α-synuclein oligomers in living cells by N′-benzylidene-benzohydrazide derivates and ferric iron

Hillmer, A. S., Putcha, P., Levin, J., Högen, T., Hyman, B. T., Kretzschmar, H., McLean, P. J. & Giese, A., Jan 1 2010, In : Biochemical and Biophysical Research Communications. 391, 1, p. 461-466 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

In vivo imaging of α-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility

Unni, V. K., Weissman, T. A., Rockenstein, E., Masliah, E., McLean, P. J. & Hyman, B. T., Sep 17 2010, In : PloS one. 5, 5, e10589.

Research output: Contribution to journalArticle

32 Scopus citations

Molecular chaperones as rational drug targets for parkinson's disease therapeutics

Kalia, S. K., Kalia, L. V. & McLean, P. J., Nov 29 2010, In : CNS and Neurological Disorders - Drug Targets. 9, 6, p. 741-753 13 p.

Research output: Contribution to journalArticle

71 Scopus citations
2009

Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system

McFarland, N. R., Lee, J. S., Hyman, B. T. & McLean, P. J., May 1 2009, In : Journal of neurochemistry. 109, 3, p. 838-845 8 p.

Research output: Contribution to journalArticle

59 Scopus citations