• 10637 Citations
  • 44 Scopus h-Index
19952019
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Research Output 1995 2019

  • 10637 Citations
  • 44 Scopus h-Index
  • 91 Article
  • 2 Chapter
  • 2 Review article
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Article
2019
7 Citations (Scopus)

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

Sun, J., Carlson-Stevermer, J., Das, U., Shen, M., Delenclos, M., Snead, A. M., Koo, S. Y., Wang, L., Qiao, D., Loi, J., Petersen, A. J., Stockton, M., Bhattacharyya, A., Jones, M. V., Zhao, X., McLean, P. J., Sproul, A. A., Saha, K. & Roy, S., Dec 1 2019, In : Nature Communications. 10, 1, 53.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
editing
Amyloid beta-Protein Precursor
Protein C
Amyloid

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease

Grozdanov, V., Bousset, L., Hoffmeister, M., Bliederhaeuser, C., Meier, C., Madiona, K., Pieri, L., Kiechle, M., McLean, P. J., Kassubek, J., Behrends, C., Ludolph, A. C., Weishaupt, J. H., Melki, R. & Danzer, K. M., Jan 1 2019, (Accepted/In press) In : Annals of neurology.

Research output: Contribution to journalArticle

Open Access
Synucleins
Parkinson Disease
Monocytes
Pathology
Central Nervous System
2018
7 Citations (Scopus)

14-3-3 proteins reduce cell-to-cell transfer and propagation of pathogenic α-synuclein

Wang, B., Underwood, R., Kamath, A., Britain, C., McFerrin, M. B., McLean, P. J., Volpicelli-Daley, L. A., Whitaker, R. H., Placzek, W. J., Becker, K., Ma, J. & Yacoubian, T. A., Sep 19 2018, In : Journal of Neuroscience. 38, 38, p. 8211-8232 22 p.

Research output: Contribution to journalArticle

Synucleins
14-3-3 Proteins
Transfer (Psychology)
Lab-On-A-Chip Devices
Neurons
3 Citations (Scopus)

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice

Cai, W., Feng, D., Schwarzschild, M. A., McLean, P. J. & Chen, X., Mar 1 2018, In : EBioMedicine. 29, p. 13-22 10 p.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Oligomerization
Fluorescence
Phenotype
2017
12 Citations (Scopus)

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

Jiang, P., Gan, M., Yen, S. H., McLean, P. J. & Dickson, D. W., Dec 1 2017, In : Scientific Reports. 7, 1, 7690.

Research output: Contribution to journalArticle

Synucleins
Lysosomes
Rupture
Membranes
Endocytosis
19 Citations (Scopus)

Investigation of endocytic pathways for the internalization of exosome-associated oligomeric alpha-synuclein

Delenclos, M., Trendafilova, T., Mahesh, D., Baine, A. M., Moussaud, S., Yan, I. K., Patel, T. C. & McLean, P. J., Mar 30 2017, In : Frontiers in Neuroscience. 11, MAR, 172.

Research output: Contribution to journalArticle

Synucleins
Exosomes
alpha-Synuclein
Conditioned Culture Medium
Parkinson Disease
3 Citations (Scopus)

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

Delenclos, M., Faroqi, A. H., Yue, M., Kurti, A., Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Fryer, J. D. & McLean, P. J., Jun 23 2017, In : Acta neuropathologica communications. 5, 1, 1 p.

Research output: Contribution to journalArticle

Synucleins
Dependovirus
alpha-Synuclein
Pathology
Brain
3 Citations (Scopus)

The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion

von Einem, B., Eschbach, J., Kiechle, M., Wahler, A., Thal, D. R., McLean, P. J., Weishaupt, J. H., Ludolph, A. C., von Arnim, C. A. F. & Danzer, K. M., Jul 1 2017, In : Aging. 9, 7, p. 1677-1697 21 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Ear
Parkinson Disease
Carrier Proteins
Endosomes
2016
1 Citation (Scopus)

A rapid, semi-quantitative assay to screen for modulators of Alpha-synuclein oligomerization ex vivo

Delenclos, M., Trendafilova, T., Jones, D. R., Moussaud, S., Baine, A. M., Yue, M., Hirst, W. D. & McLean, P. J., 2016, In : Frontiers in Neuroscience. 9, JAN, 511.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Substantia Nigra
Luminescent Proteins
Parkinson Disease
40 Citations (Scopus)

Biomarkers in Parkinson's disease: Advances and strategies

Delenclos, M., Jones, D. R., McLean, P. J. & Uitti, R. J., Jan 1 2016, In : Parkinsonism and Related Disorders. 22, p. S106-S110

Research output: Contribution to journalArticle

Parkinson Disease
Biomarkers
Neurodegenerative Diseases
Molecular Biology
Therapeutics
6 Citations (Scopus)

Histones facilitate α-synuclein aggregation during neuronal apoptosis

Jiang, P., Gan, M., Yen, S. H., McLean, P. J. & Dickson, D. W., Dec 21 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-12 12 p.

Research output: Contribution to journalArticle

Synucleins
Histones
Apoptosis
Pathology
Neurons
2 Citations (Scopus)

Intracellular formation of α-synuclein oligomers and the effect of heat shock protein 70 characterized by confocal single particle spectroscopy

Levin, J., Hillmer, A. S., Högen, T., McLean, P. J. & Giese, A., Aug 12 2016, In : Biochemical and Biophysical Research Communications. 477, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

Synucleins
HSP70 Heat-Shock Proteins
Oligomers
Spectrum Analysis
Spectroscopy
9 Citations (Scopus)

Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons

Jiang, P., Gan, M., Yen, S. H., Moussaud, S., McLean, P. J. & Dickson, D. W., Jul 1 2016, In : Acta Neuropathologica. 132, 1, p. 77-91 15 p.

Research output: Contribution to journalArticle

Synucleins
Neurons
Parkinson Disease
Nuclear Envelope
Apoptosis
8 Citations (Scopus)

The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity

Jarvela, T. S., Lam, H. A., Helwig, M., Lorenzen, N., Otzen, D. E., McLean, P. J., Maidment, N. T. & Lindberg, I., Aug 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. E4708-E4715

Research output: Contribution to journalArticle

Synucleins
Neurodegenerative Diseases
Substantia Nigra
Parkinson Disease
Lewy Bodies
2015
34 Citations (Scopus)

Chaperones in neurodegeneration

Lindberg, I., Shorter, J., Wiseman, R. L., Chiti, F., Dickey, C. A. & McLean, P. J., Oct 14 2015, In : Journal of Neuroscience. 35, 41, p. 13853-13859 7 p.

Research output: Contribution to journalArticle

Proteins
Homeostasis
Neurodegenerative Diseases
Protein Folding
Therapeutic Uses
12 Citations (Scopus)

DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients

Lorenzo-Betancor, O., Ogaki, K., Soto-Ortolaza, A. I., Labbe, C., Walton, R. L., Strongosky, A. J., Van Gerpen, J. A., Uitti, R. J., McLean, P. J., Springer, W., Siuda, J., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K., Mccarthy, A., Lynch, T., Puschmann, A., Rektorova, I., Sanotsky, Y. & 10 others, Vilariño-Güell, C., Farrer, M. J., Ferman, T. J., Boeve, B. F., Petersen, R. C., Parisi, J. E., Graff Radford, N. R., Dickson, D. W., Wszolek, Z. K. & Ross, O. A., Sep 1 2015, In : European Journal of Neurology. 22, 9, p. 1323-1325 3 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Parkinson Disease
Exons
Mutation
Introns
15 Citations (Scopus)

Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction

Gan, M., Moussaud, S., Jiang, P. & McLean, P. J., Feb 1 2015, In : Neurobiology of Aging. 36, 2, p. 1209-1220 12 p.

Research output: Contribution to journalArticle

Purinergic P2X1 Receptors
Synucleins
alpha-Synuclein
Adenosine Triphosphate
Parkinson Disease
40 Citations (Scopus)

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

Eschbach, J., Von Einem, B., Müller, K., Bayer, H., Scheffold, A., Morrison, B. E., Rudolph, K. L., Thal, D. R., Witting, A., Weydt, P., Otto, M., Fauler, M., Liss, B., McLean, P. J., La Spada, A. R., Ludolph, A. C., Weishaupt, J. H. & Danzer, K. M., Jan 1 2015, In : Annals of Neurology. 77, 1, p. 15-32 18 p.

Research output: Contribution to journalArticle

Synucleins
Peroxisome Proliferator-Activated Receptors
Parkinson Disease
Down-Regulation
Central Nervous System
68 Citations (Scopus)

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Yue, M., Hinkle, K. M., Davies, P., Trushina, E. D., Fiesel, F., Christenson, T. A., Schroeder, A. S., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S. J., Beevers, J. E., Milnerwood, A. J., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D. W., Farrer, M. J. & Melrose, H. L., Jun 1 2015, In : Neurobiology of Disease. 78, p. 172-195 24 p.

Research output: Contribution to journalArticle

Mutation
Dopamine
Phosphotransferases
Mitochondrial Dynamics
Microdialysis
17 Citations (Scopus)

Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies

Labbé, C., Ogaki, K., Lorenzo-Betancor, O., Soto-Ortolaza, A. I., Walton, R. L., Rayaprolu, S., Fujioka, S., Murray, M. E., Heckman, M. G., Puschmann, A., McCarthy, A., Lynch, T., Siuda, J., Opala, G., Rudzinska, M., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K., Sanotsky, Y., Rektorová, I. & 16 others, McLean, P. J., Rademakers, R. V., Taner, N., Hassan, A., Ahlskog, J. E., Boeve, B. F., Petersen, R. C., Maraganore, D. M., Adler, C. H., Ferman, T. J., Parisi, J. E., Graff Radford, N. R., Uitti, R. J., Wszolek, Z. K., Dickson, D. W. & Ross, O. A., Nov 10 2015, In : Neurology. 85, 19, p. 1680-1686 7 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Microtubule-Associated Proteins
Gene Frequency
Odds Ratio
Confidence Intervals
14 Citations (Scopus)

Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies

Moussaud, S., Malany, S., Mehta, A., Vasile, S., Smith, L. H. & McLean, P. J., May 1 2015, In : Expert Opinion on Therapeutic Targets. 19, 5, p. 589-603 15 p.

Research output: Contribution to journalArticle

Synucleins
Drug Discovery
Oligomers
Proteins
Oligomerization
16 Citations (Scopus)

Transmission of soluble and insoluble α-synuclein to mice

Jones, D. R., Delenclos, M., Baine, A. M. T., Deture, M., Murray, M. E., Dickson, D. W. & McLean, P. J., 2015, In : Journal of Neuropathology and Experimental Neurology. 74, 12, p. 1158-1169 12 p.

Research output: Contribution to journalArticle

Synucleins
Lewy Body Disease
Protein Isoforms
Multiple System Atrophy
Lewy Bodies
1 Citation (Scopus)

Untangling a Role for Tau in Synucleinopathies

Delenclos, M., Moussaud, S. & McLean, P. J., Nov 15 2015, In : Biological Psychiatry. 78, 10, p. 666-667 2 p.

Research output: Contribution to journalArticle

Lewy Body Disease
tau Proteins
alpha-Synuclein
Frontal Lobe
Parkinson Disease
14 Citations (Scopus)

α-Synuclein interacts with SOD1 and promotes its oligomerization

Helferich, A. M., Ruf, W. P., Grozdanov, V., Freischmidt, A., Feiler, M. S., Zondler, L., Ludolph, A. C., McLean, P. J., Weishaupt, J. H. & Danzer, K. M., Dec 8 2015, In : Molecular Neurodegeneration. 10, 1, 66.

Research output: Contribution to journalArticle

Synucleins
Neurodegenerative Diseases
Parkinson Disease
Amyotrophic Lateral Sclerosis
Erythrocytes
2014
80 Citations (Scopus)

Alpha-synuclein and tau: teammates in neurodegeneration?

Moussaud, S., Jones, D. R., Moussaud-Lamodière, E. L., Delenclos, M., Ross, O. A. & McLean, P. J., 2014, In : Molecular Neurodegeneration. 9, p. 43 1 p.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Tauopathies
Protein Unfolding
Poisons
21 Citations (Scopus)

Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss

McFarland, N. R., Dimant, H., Kibuuka, L., Ebrahimi-Fakhari, D., Desjardins, C. A., Danzer, K. M., Danzer, M., Fan, Z., Schwarzschild, M. A., Hirst, W. & McLean, P. J., Jan 20 2014, In : PLoS One. 9, 1, e86048.

Research output: Contribution to journalArticle

Synucleins
Corpus Striatum
dopamine
Toxicity
Dopamine
22 Citations (Scopus)

Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: A role for the novel interaction of alpha-synuclein and presenilin 1 in disease

Winslow, A. R., Moussaud, S., Zhu, L., Post, K. L., Dickson, D. W., Berezovska, O. & McLean, P. J., 2014, In : Brain. 137, 7, p. 1958-1970 13 p.

Research output: Contribution to journalArticle

Synucleins
Presenilin-1
Lewy Body Disease
alpha-Synuclein
Dementia
28 Citations (Scopus)

Direct detection of alpha synuclein oligomers in vivo

Dimant, H., Kalia, S. K., Kalia, L. V., Zhu, L. N., Kibuuka, L., Ebrahimi-Fakhari, D., McFarland, N. R., Fan, Z., Hyman, B. T. & McLean, P. J., Jan 27 2014, In : Acta neuropathologica communications. 2, 1, 6.

Research output: Contribution to journalArticle

alpha-Synuclein
Substantia Nigra
Dopaminergic Neurons
Parkinson Disease
Corpus Striatum
3 Citations (Scopus)

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: Implications for PD therapeutics

Dimant, H., Zhu, L., Kibuuka, L. N., Fan, Z., Hyman, B. T. & McLean, P. J., Mar 24 2014, In : PLoS One. 9, 3, e92098.

Research output: Contribution to journalArticle

alpha-Synuclein
Proteolysis
protein aggregates
Visualization
Degradation
14 Citations (Scopus)
Low Density Lipoprotein Receptor-Related Protein-1
Lipoprotein Receptors
Isoxazoles
AMPA Receptors
low density lipoprotein
29 Citations (Scopus)

Targeting heat shock proteins to modulate α-synuclein toxicity

Jones, D. R., Moussaud, S. & McLean, P. J., 2014, In : Therapeutic Advances in Neurological Disorders. 7, 1, p. 33-51 19 p.

Research output: Contribution to journalArticle

Synucleins
Heat-Shock Proteins
Parkinson Disease
Protein Refolding
Therapeutics
94 Citations (Scopus)

α-Synuclein multimers cluster synaptic vesicles and attenuate recycling

Wang, L., Das, U., Scott, D. A., Tang, Y., McLean, P. J. & Roy, S., Oct 6 2014, In : Current Biology. 24, 19, p. 2319-2326 8 p.

Research output: Contribution to journalArticle

Synucleins
Synaptic Vesicles
Recycling
recycling
Conformations
2013
11 Citations (Scopus)

Development and screening of contrast agents for in vivo imaging of Parkinson's disease

Neal, K. L., Shakerdge, N. B., Hou, S. S., Klunk, W. E., Mathis, C. A., Nesterov, E. E., Swager, T. M., McLean, P. J. & Bacskai, B. J., Oct 2013, In : Molecular Imaging and Biology. 15, 5, p. 585-595 11 p.

Research output: Contribution to journalArticle

Contrast Media
Parkinson Disease
alpha-Synuclein
Pathology
Transgenic Mice
2 Citations (Scopus)

Proteotoxicity and cardiac dysfunction [9]

Ebrahimi-Fakhari, D., McLean, P. J. & Wahlster, L., 2013, In : New England Journal of Medicine. 368, 18, p. 1754 1 p.

Research output: Contribution to journalArticle

Proteostasis Deficiencies
Myocardium
Heart Failure
Proteins
170 Citations (Scopus)

α-synuclein oligomers and clinical implications for parkinson disease

Kalia, L. V., Kalia, S. K., McLean, P. J., Lozano, A. M. & Lang, A. E., Feb 2013, In : Annals of Neurology. 73, 2, p. 155-169 15 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Neurodegenerative Diseases
Proteins
Cell Death
2012
69 Citations (Scopus)

Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway

Klucken, J., Poehler, A. M., Ebrahimi-Fakhari, D., Schneider, J., Nuber, S., Rockenstein, E., Schlötzer-Schrehardt, U., Hyman, B. T., McLean, P. J., Masliah, E. & Winkler, J., May 2012, In : Autophagy. 8, 5, p. 754-766 13 p.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Autophagy
Lewy Body Disease
Transgenic Mice
37 Citations (Scopus)

Alpha-synuclein's degradation in vivo: Opening a new (cranial) window on the roles of degradation pathways in Parkinson disease

Ebrahimi-Fakhari, D., McLean, P. J. & Unni, V. K., Feb 2012, In : Autophagy. 8, 2

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Parkinson Disease
Lewy Body Disease
Autophagy
341 Citations (Scopus)

Exosomal cell-to-cell transmission of alpha synuclein oligomers

Danzer, K. M., Kranich, L. R., Ruf, W. P., Cagsal-Getkin, O., Winslow, A. R., Zhu, L., Vanderburg, C. R. & McLean, P. J., 2012, In : Molecular Neurodegeneration. 7, 1, 42.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Exosomes
Secretory Pathway
Parkinson Disease
2361 Citations (Scopus)

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Al-Younes, H. M., Al-Zeer, M. A., Albert, M. L., Albin, R. L., Alegre-Abarrategui, J. & 1,249 others, Aleo, M. F., Alirezaei, M., Almasan, A., Almonte-Becerril, M., Amano, A., Amaravadi, R., Amarnath, S., Amer, A. O., Andrieu-Abadie, N., Anantharam, V., Ann, D. K., Anoopkumar-Dukie, S., Aoki, H., Apostolova, N., Arancia, G., Aris, J. P., Asanuma, K., Asare, N. Y. O., Ashida, H., Askanas, V., Askew, D. S., Auberger, P., Baba, M., Backues, S. K., Baehrecke, E. H., Bahr, B. A., Bai, X. Y., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Bamber, B. A., Bampton, E. T. W., Bánhegyi, G., Bartholomew, C. R., Bassham, D. C., Bast, R. C., Batoko, H., Bay, B. H., Beau, I., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Bernassola, F., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Boise, L. H., Bonaldo, P., Boone, D. L., Bornhauser, B. C., Bortoluci, K. R., Bossis, I., Bost, F., Bourquin, J. P., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Brenman, J. E., Brennand, A., Bresnick, E. H., Brest, P., Bridges, D., Bristol, M. L., Brookes, P. S., Brown, E. J., Brumell, J. H., Brunetti-Pierri, N., Brunk, U. T., Bulman, D. E., Bultman, S. J., Bultynck, G., Burbulla, L. F., Bursch, W., Butchar, J. P., Buzgariu, W., Bydlowski, S. P., Cadwell, K., Cahová, M., Cai, D., Cai, J., Cai, Q., Calabretta, B., Calvo-Garrido, J., Camougrand, N., Campanella, M., Campos-Salinas, J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Carew, J. S., Carlin, C. R., Carmignac, V., Carneiro, L. A. M., Carra, S., Caruso, R. A., Casari, G., Casas, C., Castino, R., Cebollero, E., Cecconi, F., Celli, J., Chaachouay, H., Chae, H. J., Chai, C. Y., Chan, D. C., Chan, E. Y., Chang, R. C. C., Che, C. M., Chen, C. C., Chen, G. C., Chen, G. Q., Chen, M., Chen, Q., Chen, S. S. L., Chen, W., Chen, X., Chen, X., Chen, X., Chen, Y. G., Chen, Y., Chen, Y., Chen, Y. J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Cheong, H., Cheong, J. H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H. L., Chiarelli, R., Chiba, T., Chin, L. S., Chiou, S. H., Chisari, F. V., Cho, C. H., Cho, D. H., Choi, A. M. K., Choi, D., Choi, K. S., Choi, M. E., Chouaib, S., Choubey, D., Choubey, V., Chu, C. T., Chuang, T. H., Chueh, S. H., Chun, T., Chwae, Y. J., Chye, M. L., Ciarcia, R., Ciriolo, M. R., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Clarke, R., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condello, M., Condorelli, F., Cookson, M. R., Coombs, G. H., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M., Cullen, J. J., Czaja, M. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., De Groot, J. F., De Haan, C. A. M., De Martino, L., De Milito, A., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Deng, Y. Z., Dengjel, J., Dent, P., Denton, D., Deretic, V., Desai, S. D., Devenish, R. J., Di Gioacchino, M., Di Paolo, G., Di Pietro, C., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Diaz-Nido, J., Dikic, I., Dinesh-Kumar, S. P., Ding, W. X., Distelhorst, C. W., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Dorsey, F. C., Dosenko, V., Dowling, J. J., Doxsey, S., Dreux, M., Drew, M. E., Duan, Q., Duchosal, M. A., Duff, K., Dugail, I., Durbeej, M., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Eissa, N. T., Ekmekcioglu, S., El-Deiry, W. S., Elazar, Z., Elgendy, M., Ellerby, L. M., Er Eng, K., Engelbrecht, A. M., Engelender, S., Erenpreisa, J., Escalante, R., Esclatine, A., Eskelinen, E. L., Espert, L., Espina, V., Fan, H., Fan, J., Fan, Q. W., Fan, Z., Fang, S., Fang, Y., Fanto, M., Fanzani, A., Farkas, T., Farré, J. C., Faure, M., Fechheimer, M., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Fiorito, F., Fisher, E. A., Fisher, P. B., Flajolet, M., Florez-McClure, M. L., Florio, S., Fon, E. A., Fornai, F., Fortunato, F., Fotedar, R., Fowler, D. H., Fox, H. S., Franco, R., Frankel, L. B., Fransen, M., Fuentes, J. M., Fueyo, J., Fujii, J., Fujisaki, K., Fujita, E., Fukuda, M., Furukawa, R. H., Gaestel, M., Gailly, P., Gajewska, M., Galliot, B., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F. B., Gao, G. 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X., Zorzano, A., Zschocke, J. & Zuckerbraun, B., Apr 2012, In : Autophagy. 8, 4, p. 445-544 100 p.

Research output: Contribution to journalArticle

Autophagy
Guidelines
Lysosomes
Eukaryota
Research Personnel
30 Citations (Scopus)

Molecular chaperones and co-chaperones in parkinson disease

Dimant, H., Ebrahimi-Fakhari, D. & McLean, P. J., Dec 2012, In : Neuroscientist. 18, 6, p. 589-601 13 p.

Research output: Contribution to journalArticle

Molecular Chaperones
Synucleins
Parkinson Disease
Proteins
Protein Refolding
136 Citations (Scopus)

Protein degradation pathways in Parkinson's disease: Curse or blessing

Ebrahimi-Fakhari, D., Wahlster, L. & McLean, P. J., Aug 2012, In : Acta Neuropathologica. 124, 2, p. 153-172 20 p.

Research output: Contribution to journalArticle

Proteolysis
Parkinson Disease
Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
125 Citations (Scopus)

SIRT1 protects against α-synuclein aggregation by activating molecular chaperones

Donmez, G., Arun, A., Chung, C. Y., McLean, P. J., Lindquist, S. & Guarente, L., Jan 4 2012, In : Journal of Neuroscience. 32, 1, p. 124-132 9 p.

Research output: Contribution to journalArticle

Synucleins
Molecular Chaperones
Brain
Sirtuins
Multiple System Atrophy
2011
39 Citations (Scopus)

Characterization of oligomer formation of amyloid-β peptide using a split-luciferase complementation assay

Hashimoto, T., Adams, K. W., Fan, Z., McLean, P. J. & Hyman, B. T., Aug 5 2011, In : Journal of Biological Chemistry. 286, 31, p. 27081-27091 11 p.

Research output: Contribution to journalArticle

Luciferases
Oligomers
Amyloid
Assays
Alzheimer Disease
209 Citations (Scopus)

Distinct roles in vivo for the Ubiquitin-Proteasome system and the Autophagy-Lysosomal Pathway in the Degradation of α-Synuclein

Ebrahimi-Fakhari, D., Cantuti-Castelvetri, I., Fan, Z., Rockenstein, E., Masliah, E., Hyman, B. T., McLean, P. J. & Unni, V. K., Oct 12 2011, In : Journal of Neuroscience. 31, 41, p. 14508-14520 13 p.

Research output: Contribution to journalArticle

Synucleins
Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Transgenic Mice
7 Citations (Scopus)

Drug targets from genetics: Alpha-synuclein

Danzer, K. M. & McLean, P. J., Sep 2011, In : CNS and Neurological Disorders - Drug Targets. 10, 6, p. 712-723 12 p.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Poisons
Pharmaceutical Preparations
Parkinson Disease
594 Citations (Scopus)

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

Mazzulli, J. R., Xu, Y. H., Sun, Y., Knight, A. L., McLean, P. J., Caldwell, G. A., Sidransky, E., Grabowski, G. A. & Krainc, D., Jul 8 2011, In : Cell. 146, 1, p. 37-52 16 p.

Research output: Contribution to journalArticle

Synucleins
Glucosylceramidase
Gaucher Disease
Parkinson Disease
Neurons
181 Citations (Scopus)

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

Danzer, K. M., Ruf, W. P., Putcha, P., Joyner, D., Hashimoto, T., Glabe, C., Hyman, B. T. & McLean, P. J., Jan 2011, In : FASEB Journal. 25, 1, p. 326-336 11 p.

Research output: Contribution to journalArticle

Synucleins
HSP70 Heat-Shock Proteins
Poisons
Oligomers
Toxicity
38 Citations (Scopus)

Molecular chaperones in Parkinson's disease - Present and future

Ebrahimi-Fakhari, D., Wahlster, L. & McLean, P. J., 2011, In : Journal of Parkinson's Disease. 1, 4, p. 299-320 22 p.

Research output: Contribution to journalArticle

Molecular Chaperones
Parkinson Disease
Proteins
Protein Folding
Neurodegenerative Diseases
4 Citations (Scopus)

Studying protein degradation pathways in vivo using a cranial window-based approach

Unni, V. K., Ebrahimi-Fakhari, D., Vanderburg, C. R., McLean, P. J. & Hyman, B. T., Mar 2011, In : Methods. 53, 3, p. 194-200 7 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
Neurodegenerative diseases
Degradation
74 Citations (Scopus)

Ubiquitinylation of α-synuclein by carboxyl terminus hsp70-interacting protein (chip) is regulated by bcl-2-associated athanogene 5 (bag5)

Kalia, L. V., Kalia, S. K., Chau, H., Lozano, A. M., Hyman, B. T. & McLean, P. J., 2011, In : PLoS One. 6, 2, e14695.

Research output: Contribution to journalArticle

Synucleins
Proteins
proteins
Ubiquitin-Protein Ligases
Oligomerization