Pamela J McLean, PhD

Professor

  • 9489 Citations
  • 42 h-Index
19952018
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  • 3 Similar Profiles
alpha-Synuclein Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Lewy Body Disease Medicine & Life Sciences
Lewy Bodies Medicine & Life Sciences
Proteins Medicine & Life Sciences
Neurons Medicine & Life Sciences
Molecular Chaperones Medicine & Life Sciences
Poisons Medicine & Life Sciences

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Projects 2009 2018

alpha-Synuclein
Adenosine Triphosphate
Parkinson Disease
Brain Injuries
Traumatic Brain Injury

Role of oligomeric alpha-synuclein in synucleinopathies

McLean, P. J.

National Institutes of Health

7/15/093/31/14

Project: Research projectResearch Project

alpha-Synuclein
Parkinson Disease
Lewy Bodies
Lewy Body Disease
Molecular Chaperones

Research Output 1995 2018

  • 9489 Citations
  • 42 h-Index
  • 89 Article
  • 2 Chapter
  • 1 Review article

14-3-3 proteins reduce cell-to-cell transfer and propagation of pathogenic α-synuclein

Wang, B., Underwood, R., Kamath, A., Britain, C., McFerrin, M. B., McLean, P. J., Volpicelli-Daley, L. A., Whitaker, R. H., Placzek, W. J., Becker, K., Ma, J. & Yacoubian, T. A., Sep 19 2018, In : Journal of Neuroscience. 38, 38, p. 8211-8232 22 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
alpha-Synuclein
Transfer (Psychology)
Lab-On-A-Chip Devices
Neurons
1 Citations

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice

Cai, W., Feng, D., Schwarzschild, M. A., McLean, P. J. & Chen, X., Mar 1 2018, In : EBioMedicine. 29, p. 13-22 10 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Oligomerization
Parkinson Disease
Fluorescence
Phenotype
182 Citations

Diagnosis and management of dementia with Lewy bodies

McKeith, I. G., Boeve, B. F., Dickson, D. W., Halliday, G., Taylor, J. P., Weintraub, D., Aarsland, D., Galvin, J., Attems, J., Ballard, C. G., Bayston, A., Beach, T. G., Blanc, F., Bohnen, N., Bonanni, L., Bras, J., Brundin, P., Burn, D., Chen-Plotkin, A., Duda, J. E. & 43 othersEl-Agnaf, O., Feldman, H., Ferman, T. J., Ffytche, D., Fujishiro, H., Galasko, D., Goldman, J. G., Gomperts, S. N., Graff Radford, N. R., Honig, L. S., Iranzo, A., Kantarci, K. M., Kaufer, D., Kukull, W., Lee, V. M. Y., Leverenz, J. B., Lewis, S., Lippa, C., Lunde, A., Masellis, M., Masliah, E., McLean, P. J., Mollenhauer, B., Montine, T. J., Moreno, E., Mori, E., Murray, M. E., O'Brien, J. T., Orimo, S., Postuma, R. B., Ramaswamy, S., Ross, O. A., Salmon, D. P., Singleton, A., Taylor, A., Thomas, A., Tiraboschi, P., Toledo, J. B., Trojanowski, J. Q., Tsuang, D., Walker, Z., Yamada, M. & Kosaka, K., Jul 4 2017, In : Neurology. 89, 1, p. 88-100 13 p.

Research output: Contribution to journalReview article

Lewy Body Disease
REM Sleep Behavior Disorder
Lewy Bodies
Myocardial Perfusion Imaging
Neurobiology
8 Citations

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

Jiang, P., Gan, M., Yen, S. H., McLean, P. J. & Dickson, D. W., Dec 1 2017, In : Scientific Reports. 7, 1, 7690.

Research output: Contribution to journalArticle

alpha-Synuclein
Lysosomes
Rupture
Membranes
Endocytosis
9 Citations

Investigation of endocytic pathways for the internalization of exosome-associated oligomeric alpha-synuclein

Delenclos, M., Trendafilova, T., Mahesh, D., Baine, A. M., Moussaud, S., Yan, I. K., Patel, T. C. & McLean, P. J., Mar 30 2017, In : Frontiers in Neuroscience. 11, MAR, 172.

Research output: Contribution to journalArticle

Exosomes
alpha-Synuclein
Conditioned Culture Medium
Parkinson Disease
Caveolins