• 10637 Citations
  • 44 Scopus h-Index
19952019
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Fingerprint Dive into the research topics where Pamela J McLean is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Synucleins Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
alpha-Synuclein Medicine & Life Sciences
Lewy Body Disease Medicine & Life Sciences
Lewy Bodies Medicine & Life Sciences
Proteins Medicine & Life Sciences
Neurons Medicine & Life Sciences
Toxicity Chemical Compounds

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Projects 2009 2018

alpha-Synuclein
Adenosine Triphosphate
Parkinson Disease
Brain Injuries
Traumatic Brain Injury
alpha-Synuclein
Parkinson Disease
Lewy Bodies
Lewy Body Disease
Molecular Chaperones

Research Output 1995 2019

  • 10637 Citations
  • 44 Scopus h-Index
  • 91 Article
  • 2 Chapter
  • 2 Review article
1 Citation (Scopus)

Cellular models of alpha-synuclein toxicity and aggregation

Delenclos, M., Burgess, J. D., Lamprokostopoulou, A., Outeiro, T. F., Vekrellis, K. & McLean, P. J., Jan 1 2019, In : Journal of neurochemistry. 150, 5, p. 566-576 11 p.

Research output: Contribution to journalReview article

Open Access
Synucleins
alpha-Synuclein
Toxicity
Agglomeration
Neurons
7 Citations (Scopus)

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

Sun, J., Carlson-Stevermer, J., Das, U., Shen, M., Delenclos, M., Snead, A. M., Koo, S. Y., Wang, L., Qiao, D., Loi, J., Petersen, A. J., Stockton, M., Bhattacharyya, A., Jones, M. V., Zhao, X., McLean, P. J., Sproul, A. A., Saha, K. & Roy, S., Dec 1 2019, In : Nature Communications. 10, 1, 53.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
editing
Amyloid beta-Protein Precursor
Protein C
Amyloid

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease

Grozdanov, V., Bousset, L., Hoffmeister, M., Bliederhaeuser, C., Meier, C., Madiona, K., Pieri, L., Kiechle, M., McLean, P. J., Kassubek, J., Behrends, C., Ludolph, A. C., Weishaupt, J. H., Melki, R. & Danzer, K. M., Jan 1 2019, (Accepted/In press) In : Annals of neurology.

Research output: Contribution to journalArticle

Open Access
Synucleins
Parkinson Disease
Monocytes
Pathology
Central Nervous System
7 Citations (Scopus)

14-3-3 proteins reduce cell-to-cell transfer and propagation of pathogenic α-synuclein

Wang, B., Underwood, R., Kamath, A., Britain, C., McFerrin, M. B., McLean, P. J., Volpicelli-Daley, L. A., Whitaker, R. H., Placzek, W. J., Becker, K., Ma, J. & Yacoubian, T. A., Sep 19 2018, In : Journal of Neuroscience. 38, 38, p. 8211-8232 22 p.

Research output: Contribution to journalArticle

Synucleins
14-3-3 Proteins
Transfer (Psychology)
Lab-On-A-Chip Devices
Neurons
3 Citations (Scopus)

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice

Cai, W., Feng, D., Schwarzschild, M. A., McLean, P. J. & Chen, X., Mar 1 2018, In : EBioMedicine. 29, p. 13-22 10 p.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Oligomerization
Fluorescence
Phenotype