Pamela J McLean, PhD

Professor

  • 9689 Citations
  • 42 h-Index
19952019
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  • 4 Similar Profiles
alpha-Synuclein Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Lewy Body Disease Medicine & Life Sciences
Lewy Bodies Medicine & Life Sciences
Proteins Medicine & Life Sciences
Neurons Medicine & Life Sciences
Molecular Chaperones Medicine & Life Sciences
Poisons Medicine & Life Sciences

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Projects 2009 2018

alpha-Synuclein
Adenosine Triphosphate
Parkinson Disease
Brain Injuries
Traumatic Brain Injury

Role of oligomeric alpha-synuclein in synucleinopathies

McLean, P. J.

National Institutes of Health

7/15/093/31/14

Project: Research projectResearch Project

alpha-Synuclein
Parkinson Disease
Lewy Bodies
Lewy Body Disease
Molecular Chaperones

Research Output 1995 2019

  • 9689 Citations
  • 42 h-Index
  • 90 Article
  • 2 Chapter
  • 1 Review article

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

Sun, J., Carlson-Stevermer, J., Das, U., Shen, M., Delenclos, M., Snead, A. M., Koo, S. Y., Wang, L., Qiao, D., Loi, J., Petersen, A. J., Stockton, M., Bhattacharyya, A., Jones, M. V., Zhao, X., McLean, P. J., Sproul, A. A., Saha, K. & Roy, S., Dec 1 2019, In : Nature communications. 10, 1, 53.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
editing
Amyloid beta-Protein Precursor
Protein C
Amyloid
1 Citations

14-3-3 proteins reduce cell-to-cell transfer and propagation of pathogenic α-synuclein

Wang, B., Underwood, R., Kamath, A., Britain, C., McFerrin, M. B., McLean, P. J., Volpicelli-Daley, L. A., Whitaker, R. H., Placzek, W. J., Becker, K., Ma, J. & Yacoubian, T. A., Sep 19 2018, In : Journal of Neuroscience. 38, 38, p. 8211-8232 22 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
alpha-Synuclein
Transfer (Psychology)
Lab-On-A-Chip Devices
Neurons
1 Citations

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice

Cai, W., Feng, D., Schwarzschild, M. A., McLean, P. J. & Chen, X., Mar 1 2018, In : EBioMedicine. 29, p. 13-22 10 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Oligomerization
Parkinson Disease
Fluorescence
Phenotype
226 Citations

Diagnosis and management of dementia with Lewy bodies

McKeith, I. G., Boeve, B. F., Dickson, D. W., Halliday, G., Taylor, J. P., Weintraub, D., Aarsland, D., Galvin, J., Attems, J., Ballard, C. G., Bayston, A., Beach, T. G., Blanc, F., Bohnen, N., Bonanni, L., Bras, J., Brundin, P., Burn, D., Chen-Plotkin, A., Duda, J. E. & 43 othersEl-Agnaf, O., Feldman, H., Ferman, T. J., Ffytche, D., Fujishiro, H., Galasko, D., Goldman, J. G., Gomperts, S. N., Graff Radford, N. R., Honig, L. S., Iranzo, A., Kantarci, K. M., Kaufer, D., Kukull, W., Lee, V. M. Y., Leverenz, J. B., Lewis, S., Lippa, C., Lunde, A., Masellis, M., Masliah, E., McLean, P. J., Mollenhauer, B., Montine, T. J., Moreno, E., Mori, E., Murray, M. E., O'Brien, J. T., Orimo, S., Postuma, R. B., Ramaswamy, S., Ross, O. A., Salmon, D. P., Singleton, A., Taylor, A., Thomas, A., Tiraboschi, P., Toledo, J. B., Trojanowski, J. Q., Tsuang, D., Walker, Z., Yamada, M. & Kosaka, K., Jul 4 2017, In : Neurology. 89, 1, p. 88-100 13 p.

Research output: Contribution to journalReview article

Lewy Body Disease
REM Sleep Behavior Disorder
Lewy Bodies
Myocardial Perfusion Imaging
Neurobiology
8 Citations

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

Jiang, P., Gan, M., Yen, S. H., McLean, P. J. & Dickson, D. W., Dec 1 2017, In : Scientific Reports. 7, 1, 7690.

Research output: Contribution to journalArticle

alpha-Synuclein
Lysosomes
Rupture
Membranes
Endocytosis