• 11671 Citations
  • 46 Scopus h-Index
19952020

Research output per year

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Research Output

  • 11671 Citations
  • 46 Scopus h-Index
  • 85 Article
  • 10 Review article
  • 2 Chapter
  • 1 Letter
1995
52 Scopus citations
1999

Notch1 inhibits neurite outgrowth in postmitotic primary neurons

Berezovska, O., McLean, P., Knowles, R., Frosh, M., Lu, F. M., Lux, S. E. & Hyman, B. T., Jul 1 1999, In : Neuroscience. 93, 2, p. 433-439 7 p.

Research output: Contribution to journalArticle

180 Scopus citations

The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons

Berezovska, O., Frosch, M., McLean, P., Knowles, R., Koo, E., Kang, D., Shen, J., Lu, F. M., Lux, S. E., Tonegawa, S. & Hyman, B. T., Jun 10 1999, In : Molecular Brain Research. 69, 2, p. 273-280 8 p.

Research output: Contribution to journalArticle

59 Scopus citations
2000

A minimal promoter for the GABA(A) receptor α6-subunit gene controls tissue specificity

McLean, P. J., Shpektor, D., Bandyopadhyay, S., Russek, S. J. & Farb, D. H., May 3 2000, In : Journal of neurochemistry. 74, 5, p. 1858-1869 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Aspartate mutations in presenilin and γ-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch1 signaling

Berezovska, O., Jack, C., McLean, P., Aster, J. C., Hicks, C., Xia, W., Wolfe, M. S., Kimberly, W. T., Weinmaster, G., Selkoe, D. J. & Hyman, B. T., Aug 7 2000, In : Journal of neurochemistry. 75, 2, p. 583-593 11 p.

Research output: Contribution to journalArticle

110 Scopus citations

Membrane association and protein conformation of α-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations

McLean, P. J., Kawamata, H., Ribich, S. & Hyman, B. T., Mar 24 2000, In : Journal of Biological Chemistry. 275, 12, p. 8812-8816 5 p.

Research output: Contribution to journalArticle

205 Scopus citations

Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated γ-secretase activity

Berezovska, O., Jack, C., McLean, P., Aster, J. C., Hicks, C., Weiming, X. I. A., Wolfe, M. S., Weinmaster, G., Selkoe, D. J. & Hyman, B. T., 2000, In : Annals of the New York Academy of Sciences. 920, p. 223-226 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

Subcellular localization of α-synuclein in primary neuronal cultures: Effect of missense mutations

McLean, P. J., Ribich, S. & Hyman, B. T., Jan 1 2000, In : Journal of Neural Transmission, Supplement. 58, p. 53-63 11 p.

Research output: Contribution to journalArticle

48 Scopus citations
2001

A close association of torsinA and α-synuclein in lewy bodies: A fluorescence resonance energy transfer study

Sharma, N., Hewett, J., Ozelius, L. J., Ramesh, V., McLean, P. J., Breakefield, X. O. & Hyman, B. T., Jul 2001, In : American Journal of Pathology. 159, 1, p. 339-344 6 p.

Research output: Contribution to journalArticle

92 Scopus citations

Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies

Sharma, N., McLean, P. J., Kawamata, H., Irizarry, M. C. & Hyman, B. T., 2001, In : Acta neuropathologica. 102, 4, p. 329-334 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Interaction of α-synuclein and synphilin-1: Effect of Parkinson's disease-associated mutations

Kawamata, H., McLean, P. J., Sharma, N. & Hyman, B. T., Jun 4 2001, In : Journal of neurochemistry. 77, 3, p. 929-934 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

α-Synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

McLean, P. J., Kawamata, H. & Hyman, B. T., Jun 14 2001, In : Neuroscience. 104, 3, p. 901-912 12 p.

Research output: Contribution to journalArticle

164 Scopus citations
2002
26 Scopus citations

TorsinA and heat shock proteins act as molecular chaperones: Suppression of α-synuclein aggregation

McLean, P. J., Kawamata, H., Shariff, S., Hewett, J., Sharma, N., Ueda, K., Breakefield, X. O. & Hyman, B. T., Nov 1 2002, In : Journal of neurochemistry. 83, 4, p. 846-854 9 p.

Research output: Contribution to journalArticle

251 Scopus citations
2003

Neuritic Alterations and Neural System Dysfunction in Alzheimer's Disease and Dementia with Lewy Bodies

Klucken, J., McLean, P. J., Gomez-Tortosa, E., Ingelsson, M. & Hyman, B. T., Nov 1 2003, In : Neurochemical Research. 28, 11, p. 1683-1691 9 p.

Research output: Contribution to journalReview article

25 Scopus citations
2004

A single amino acid substitution differentiates Hsp70-dependent effects on α-synuclein degradation and toxicity

Klucken, J., Shin, Y., Hyman, B. T. & McLean, P. J., Dec 3 2004, In : Biochemical and Biophysical Research Communications. 325, 1, p. 367-373 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Geldanamycin induces Hsp70 and prevents α-synuclein aggregation and toxicity in vitro

McLean, P. J., Klucken, J., Shin, Y. & Hyman, B. T., Aug 27 2004, In : Biochemical and Biophysical Research Communications. 321, 3, p. 665-669 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

Hsp70 reduces α-synuclein aggregation and toxicity

Klucken, J., Shin, Y., Masliah, E., Hyman, B. T. & McLean, P. J., Jun 11 2004, In : Journal of Biological Chemistry. 279, 24, p. 25497-25502 6 p.

Research output: Contribution to journalArticle

359 Scopus citations
2005

Alpha-synuclein and chaperones in dementia with Lewy bodies

Cantuti-Castelvetri, I., Klucken, J., Ingelsson, M., Ramasamy, K., McLean, P. J., Frosch, M. P., Hyman, B. T. & Standaert, D. G., Dec 1 2005, In : Journal of Neuropathology and Experimental Neurology. 64, 12, p. 1058-1066 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

Spires, T. L., Meyer-Luehmann, M., Stern, E. A., McLean, P. J., Skoch, J., Nguyen, P. T., Bacskai, B. J. & Hyman, B. T., Aug 3 2005, In : Journal of Neuroscience. 25, 31, p. 7278-7287 10 p.

Research output: Contribution to journalArticle

416 Scopus citations

The Co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates α-synuclein degradation decisions between proteasomal and lysosomal pathways

Shin, Y., Klucken, J., Patterson, C., Hyman, B. T. & McLean, P. J., Jun 24 2005, In : Journal of Biological Chemistry. 280, 25, p. 23727-23734 8 p.

Research output: Contribution to journalArticle

229 Scopus citations
2006

Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway

Giaime, E., Sunyach, C., Herrant, M., Grosso, S., Auberge, P., McLean, P. J., Checler, F. & Alves Da Costa, C., Apr 28 2006, In : Journal of Biological Chemistry. 281, 17, p. 11515-11522 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Clinical and biochemical correlates of insoluble α-synuclein in dementia with Lewy bodies

Klucken, J., Ingelsson, M., Shin, Y., Irizarry, M. C., Hedley-Whyte, E. T., Frosch, M. P., Growdon, J. H., McLean, P. J. & Hyman, B. T., Feb 1 2006, In : Acta neuropathologica. 111, 2, p. 101-108 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Detection of novel intracellular α-synuclein oligomeric species by fluorescence lifetime imaging

Klucken, J., Outeiro, T. F., Nguyen, P., McLean, P. J. & Hyman, B. T., Oct 1 2006, In : FASEB Journal. 20, 12, p. 2050-2057 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases

Bodner, R. A., Outeiro, T. F., Altmann, S., Maxwell, M. M., Cho, S. H., Hyman, B. T., McLean, P. J., Young, A. B., Housman, D. E. & Kazantsev, A. G., Mar 14 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 11, p. 4246-4251 6 p.

Research output: Contribution to journalArticle

212 Scopus citations

Small heat shock proteins protect against α-synuclein-induced toxicity and aggregation

Outeiro, T. F., Klucken, J., Strathearn, K. E., Liu, F., Nguyen, P., Rochet, J. C., Hyman, B. T. & McLean, P. J., Dec 22 2006, In : Biochemical and Biophysical Research Communications. 351, 3, p. 631-638 8 p.

Research output: Contribution to journalArticle

129 Scopus citations
2007

Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra

St Martin, J. L., Klucken, J., Outeiro, T. F., Nguyen, P., Keller-McGandy, C., Cantuti-Castelvetri, I., Grammatopoulos, T. N., Standaert, D. G., Hyman, B. T. & McLean, P. J., Mar 1 2007, In : Journal of neurochemistry. 100, 6, p. 1449-1457 9 p.

Research output: Contribution to journalArticle

116 Scopus citations

Protein aggregation disorders

Outeiro, T. F., McLean, P. J. & Hyman, B. T., Dec 1 2007, Neurobiology of Disease. Elsevier Inc., p. 111-123 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease

Outeiro, T. F., Kontopoulos, E., Altmann, S. M., Kufareva, I., Strathearn, K. E., Amore, A. M., Volk, C. B., Maxwell, M. M., Rochet, J. C., McLean, P. J., Young, A. B., Abagyan, R., Feany, M. B., Hyman, B. T. & Kazantsev, A. G., Jul 27 2007, In : Science. 317, 5837, p. 516-519 4 p.

Research output: Contribution to journalArticle

749 Scopus citations
2008

CHIP targets toxic α-synuclein oligomers for degradation

Tetzlaff, J. E., Putcha, P., Outeiro, T. F., Ivanov, A., Berezovska, O., Hyman, B. T. & McLean, P. J., Jun 27 2008, In : Journal of Biological Chemistry. 283, 26, p. 17962-17968 7 p.

Research output: Contribution to journalArticle

112 Scopus citations

Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

Mollenhauer, B., Cullen, V., Kahn, I., Krastins, B., Outeiro, T. F., Pepivani, I., Ng, J., Schulz-Schaeffer, W., Kretzschmar, H. A., McLean, P. J., Trenkwalder, C., Sarracino, D. A., VonSattel, J. P., Locascio, J. J., El-Agnaf, O. M. A. & Schlossmacher, M. G., Oct 1 2008, In : Experimental Neurology. 213, 2, p. 315-325 11 p.

Research output: Contribution to journalArticle

280 Scopus citations

Formation of toxic oligomeric α-synuclein species in living cells

Outeiro, T. F., Putcha, P., Tetzlaff, J. E., Spoelgen, R., Koker, M., Carvalho, F., Hyman, B. T. & McLean, P. J., Apr 2 2008, In : PloS one. 3, 4, e1867.

Research output: Contribution to journalArticle

280 Scopus citations
174 Scopus citations

Transcriptional dysregulation in a transgenic model of Parkinson disease

Yacoubian, T. A., Cantuti-Castelvetri, I., Bouzou, B., Asteris, G., McLean, P. J., Hyman, B. T. & Standaert, D. G., Mar 1 2008, In : Neurobiology of Disease. 29, 3, p. 515-528 14 p.

Research output: Contribution to journalArticle

51 Scopus citations
2009

Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system

McFarland, N. R., Lee, J. S., Hyman, B. T. & McLean, P. J., May 1 2009, In : Journal of neurochemistry. 109, 3, p. 838-845 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Dopamine-induced conformational changes in alpha-synuclein

Outerio, T. F., Klucken, J., Bercury, K., Tetzlaff, J., Putcha, P., Oliveira, L. M. A., Quintas, A., McLean, P. J. & Hyman, B. T., Sep 4 2009, In : PloS one. 4, 9, e6906.

Research output: Contribution to journalArticle

45 Scopus citations

Tyrosine and serine phosphorylation of α-synuclein have opposing effects on neurotoxicity and soluble oligomer formation

Chen, L., Periquet, M., Wang, X., Negro, A., McLean, P. J., Hyman, B. T. & Feany, M. B., Nov 2 2009, In : Journal of Clinical Investigation. 119, 11, p. 3257-3265 9 p.

Research output: Contribution to journalArticle

131 Scopus citations

α-Synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of parkinson disease

McFarland, N. R., Fan, Z., Xu, K., Schwarzschild, M. A., Feany, M. B., Hyman, B. T. & McLean, P. J., May 2009, In : Journal of Neuropathology and Experimental Neurology. 68, 5, p. 515-524 10 p.

Research output: Contribution to journalArticle

80 Scopus citations
2010

Brain-permeable small-molecule inhibitors of Hsp90 prevent α-synuclein oligomer formation and rescue α-synuclein-induced toxicity

Putcha, P., Danzer, K. M., Kranich, L. R., Scott, A., Silinski, M., Mabbett, S., Hicks, C. D., Veal, J. M., Steed, P. M., Hyman, B. T. & McLean, P. J., Mar 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, 3, p. 849-857 9 p.

Research output: Contribution to journalArticle

110 Scopus citations

Converse modulation of toxic α-synuclein oligomers in living cells by N′-benzylidene-benzohydrazide derivates and ferric iron

Hillmer, A. S., Putcha, P., Levin, J., Högen, T., Hyman, B. T., Kretzschmar, H., McLean, P. J. & Giese, A., Jan 1 2010, In : Biochemical and Biophysical Research Communications. 391, 1, p. 461-466 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

In vivo imaging of α-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility

Unni, V. K., Weissman, T. A., Rockenstein, E., Masliah, E., McLean, P. J. & Hyman, B. T., Sep 17 2010, In : PloS one. 5, 5, e10589.

Research output: Contribution to journalArticle

32 Scopus citations

Molecular chaperones as rational drug targets for parkinson's disease therapeutics

Kalia, S. K., Kalia, L. V. & McLean, P. J., Nov 29 2010, In : CNS and Neurological Disorders - Drug Targets. 9, 6, p. 741-753 13 p.

Research output: Contribution to journalArticle

71 Scopus citations
2011

Characterization of oligomer formation of amyloid-β peptide using a split-luciferase complementation assay

Hashimoto, T., Adams, K. W., Fan, Z., McLean, P. J. & Hyman, B. T., Aug 5 2011, In : Journal of Biological Chemistry. 286, 31, p. 27081-27091 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Distinct roles in vivo for the Ubiquitin-Proteasome system and the Autophagy-Lysosomal Pathway in the Degradation of α-Synuclein

Ebrahimi-Fakhari, D., Cantuti-Castelvetri, I., Fan, Z., Rockenstein, E., Masliah, E., Hyman, B. T., McLean, P. J. & Unni, V. K., Oct 12 2011, In : Journal of Neuroscience. 31, 41, p. 14508-14520 13 p.

Research output: Contribution to journalArticle

229 Scopus citations

Drug targets from genetics: Alpha-synuclein

Danzer, K. M. & Mclean, P. J., Sep 2011, In : CNS and Neurological Disorders - Drug Targets. 10, 6, p. 712-723 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

Mazzulli, J. R., Xu, Y. H., Sun, Y., Knight, A. L., McLean, P. J., Caldwell, G. A., Sidransky, E., Grabowski, G. A. & Krainc, D., Jul 8 2011, In : Cell. 146, 1, p. 37-52 16 p.

Research output: Contribution to journalArticle

677 Scopus citations

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

Danzer, K. M., Ruf, W. P., Putcha, P., Joyner, D., Hashimoto, T., Glabe, C., Hyman, B. T. & McLean, P. J., Jan 1 2011, In : FASEB Journal. 25, 1, p. 326-336 11 p.

Research output: Contribution to journalArticle

194 Scopus citations

Molecular chaperones in Parkinson's disease - Present and future

Ebrahimi-Fakhari, D., Wahlster, L. & McLean, P. J., Dec 1 2011, In : Journal of Parkinson's disease. 1, 4, p. 299-320 22 p.

Research output: Contribution to journalReview article

43 Scopus citations

Studying protein degradation pathways in vivo using a cranial window-based approach

Unni, V. K., Ebrahimi-Fakhari, D., Vanderburg, C. R., McLean, P. J. & Hyman, B. T., Mar 1 2011, In : Methods. 53, 3, p. 194-200 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ubiquitinylation of α-synuclein by carboxyl terminus hsp70-interacting protein (chip) is regulated by bcl-2-associated athanogene 5 (bag5)

Kalia, L. V., Kalia, S. K., Chau, H., Lozano, A. M., Hyman, B. T. & McLean, P. J., 2011, In : PloS one. 6, 2, e14695.

Research output: Contribution to journalArticle

81 Scopus citations