Larry M Karnitz, PhD

  • 6551 Citations
  • 41 Scopus h-Index
1984 …2021
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Fingerprint Dive into the research topics where Larry M Karnitz is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
DNA Damage Medicine & Life Sciences
gemcitabine Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
tanespimycin Medicine & Life Sciences
Phosphatidylinositol 3-Kinase Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Cells Chemical Compounds
DNA Repair Medicine & Life Sciences

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Projects 1997 2021

CDK12 in Ovarian Cancer

Karnitz, L. M.

National Institutes of Health


Project: Research project

Cyclin-Dependent Kinases
Ovarian Neoplasms
Homologous Recombination
Acute Myeloid Leukemia
Myeloid Cells
Molecular Biology
HSP90 Heat-Shock Proteins
Ovarian Neoplasms
DNA Damage
Genomic Instability
Cell Cycle Checkpoints
DNA Repair

Research Output 1984 2019

  • 6551 Citations
  • 41 Scopus h-Index
  • 76 Article
1 Citation (Scopus)

Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo

Vincelette, N. D., Ding, H., Huehls, A. M., Flatten, K. S., Kelly, R. L., Kohorst, M. A., Webster, J., Hess, A. D., Pratz, K. W., Karnitz, L. M. & Kaufmann, S. H., Dec 1 2019, In : Scientific reports. 9, 1, 3617.

Research output: Contribution to journalArticle

Open Access
Acute Myeloid Leukemia
G2 Phase Cell Cycle Checkpoints
In Vitro Techniques

ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

Kanakkanthara, A., Huntoon, C. J., Hou, X., Zhang, M., Heinzen, E. P., O’Brien, D. R., Oberg, A. L., John Weroha, S., Kaufmann, S. H. & Karnitz, L. M., Dec 1 2019, In : Nature communications. 10, 1, 4632.

Research output: Contribution to journalArticle

Open Access
Homologous Recombination
Ovarian Neoplasms
Messenger RNA
11 Citations (Scopus)

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye-Agyeman, F., Gonsalves, W., Lou, Z., Karnitz, L. M., Goetz, M. P. & Hitosugi, T. D., Feb 6 2018, In : Cell Reports. 22, 6, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

Carnitine O-Palmitoyltransferase
Phosphopyruvate Hydratase
Isotope Labeling
5 Citations (Scopus)

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

Kurmi, K., Hitosugi, S., Yu, J., Boakye-Agyeman, F., Wiese, E. K., Larson, T. R., Dai, Q., Machida, Y., Lou, Z., Wang, L. M., Boughey, J. C., Kaufmann, S. H., Goetz, M. P., Karnitz, L. M. & Hitosugi, T. D., Dec 4 2018, In : Cell Metabolism. 28, 6, p. 833-847.e8

Research output: Contribution to journalArticle

Mitochondrial Form Creatine Kinase
Breast Neoplasms
21 Citations (Scopus)

A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia

Gojo, I., Beumer, J. H., Pratz, K. W., McDevitt, M. A., Baer, M. R., Blackford, A. L., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Levis, M. J., Dezern, A. E., Gladstone, D. E., Ji, J. J., Wang, L., Kinders, R. J., Pouquet, M., Ali-Walbi, I., Rudek, M. A., Poh, W. & 5 others, Herman, J. G., Karnitz, L. M., Kaufmann, S. H., Chen, A. & Karp, J. E., Feb 1 2017, In : Clinical Cancer Research. 23, 3, p. 697-706 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia