Larry M Karnitz, PhD

Professor

  • 6252 Citations
  • 41 h-Index
1984 …2021
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  • 2 Similar Profiles
DNA Damage Medicine & Life Sciences
gemcitabine Medicine & Life Sciences
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Phosphatidylinositol 3-Kinase Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Cells Chemical Compounds
DNA Repair Medicine & Life Sciences

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Projects 1997 2021

CDK12 in Ovarian Cancer

Karnitz, L. M.

National Institutes of Health

12/1/1511/30/20

Project: Research projectResearch Project

Cyclin-Dependent Kinases
Ovarian Neoplasms
Homologous Recombination
Neoplasms
Phosphorylation

Targeting Chk1 in Acute Myeloid Leukemia

Karnitz, L. M.

National Institutes of Health

7/24/156/30/20

Project: Research projectResearch Project

Acute Myeloid Leukemia
Myeloid Cells
Therapeutics
Biomarkers
Anthracyclines

Predoctoral Training Program in Molecular Pharmacology

Karnitz, L. M. & Ames, M.

National Institutes of Health

8/10/056/30/21

Project: Research projectInstitutional National Research Service Award

Pharmacology
Students
Education
Research
Molecular Biology

Therapeutic targeting of HSP90-dependent signaling

Karnitz, L. M.

National Institutes of Health

4/1/042/28/10

Project: Research projectResearch Project

tanespimycin
HSP90 Heat-Shock Proteins
gemcitabine
Ovarian Neoplasms
Cisplatin

ANALYSIS OF A DNA DAMAGE INDUCIBLE CHECKPOINT COMPLEX

Karnitz, L. M.

National Institutes of Health

12/1/996/30/11

Project: Research projectResearch Project, High Priority, Short Term Project Award

DNA Damage
Genomic Instability
Cell Cycle Checkpoints
DNA Repair
DNA

Research Output 1984 2018

  • 6252 Citations
  • 41 h-Index
  • 73 Article
5 Citations

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye-Agyeman, F., Gonsalves, W., Lou, Z., Karnitz, L. M., Goetz, M. P. & Hitosugi, T. D., Feb 6 2018, In : Cell Reports. 22, 6, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

Carnitine O-Palmitoyltransferase
Lysine
Phosphopyruvate Hydratase
Isotope Labeling
Mutation
9 Citations

A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia

Gojo, I., Beumer, J. H., Pratz, K. W., McDevitt, M. A., Baer, M. R., Blackford, A. L., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Levis, M. J., Dezern, A. E., Gladstone, D. E., Ji, J. J., Wang, L., Kinders, R. J., Pouquet, M., Ali-Walbi, I., Rudek, M. A., Poh, W. & 5 othersHerman, J. G., Karnitz, L. M., Kaufmann, S. H., Chen, A. & Karp, J. E., Feb 1 2017, In : Clinical Cancer Research. 23, 3, p. 697-706 10 p.

Research output: Contribution to journalArticle

temozolomide
Acute Myeloid Leukemia
Methylation
Phosphorylation
Polymers
6 Citations

A phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms, and chronic myelomonocytic leukemia

Pratz, K. W., Rudek, M. A., Gojo, I., Litzow, M. R., McDevitt, M. A., Ji, J., Karnitz, L. M., Herman, J. G., Kinders, R. J., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Gladstone, D. E., Levis, M. J., Tsai, H. L., Rosner, G., Chen, A., Kaufmann, S. H. & Karp, J. E., Feb 15 2017, In : Clinical Cancer Research. 23, 4, p. 899-907 9 p.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Topotecan
Carboplatin
Leukemia
Neoplasms
6 Citations

Randomized phase II trial of cytosine arabinoside with and without the CHK1 inhibitor MK-8776 in relapsed and refractory acute myeloid leukemia

Webster, J. A., Tibes, R., Morris, L., Blackford, A. L., Litzow, M. R., Patnaik, M. M., Rosner, G. L., Gojo, I., Kinders, R., Wang, L., Doyle, L. A., Huntoon, C. J., Karnitz, L. M., Kaufmann, S. H., Karp, J. E. & Smith, B. D., Oct 1 2017, In : Leukemia Research. 61, p. 108-116 9 p.

Research output: Contribution to journalArticle

Cytarabine
Acute Myeloid Leukemia
DNA Damage
Cell Cycle Checkpoints
MK-8776
11 Citations

Genomically incorporated 5-fluorouracil that escapes ung-initiated base excision repair blocks dna replication and activates homologous recombination

Huehls, A. M., Huntoon, C. J., Joshi, P. M., Baehr, C. A., Wagner, J. M., Wang, X., Lee, M. Y. & Karnitz, L. M., Jan 1 2016, In : Molecular Pharmacology. 89, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

Homologous Recombination
Fluorouracil
DNA Repair
Floxuridine
Uracil-DNA Glycosidase