Larry M Karnitz, PhD &ndash; Research Output

2019

Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo

Vincelette, N. D., Ding, H., Huehls, A. M., Flatten, K. S., Kelly, R. L., Kohorst, M. A., Webster, J., Hess, A. D., Pratz, K. W., Karnitz, L. M. & Kaufmann, S. H., Dec 1 2019, In : Scientific reports. 9, 1, 3617.

Research output: Contribution to journal › Article

Open Access

Acute Myeloid Leukemia

Cytarabine

Daunorubicin

G2 Phase Cell Cycle Checkpoints

In Vitro Techniques

2018

8 Citations (Scopus)

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye-Agyeman, F., Gonsalves, W., Lou, Z., Karnitz, L. M., Goetz, M. P. & Hitosugi, T. D., Feb 6 2018, In : Cell Reports. 22, 6, p. 1365-1373 9 p.

Research output: Contribution to journal › Article

Carnitine O-Palmitoyltransferase

Lysine

Phosphopyruvate Hydratase

Isotope Labeling

Mutation

4 Citations (Scopus)

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

Kurmi, K., Hitosugi, S., Yu, J., Boakye-Agyeman, F., Wiese, E. K., Larson, T. R., Dai, Q., Machida, Y., Lou, Z., Wang, L. M., Boughey, J. C., Kaufmann, S. H., Goetz, M. P., Karnitz, L. M. & Hitosugi, T. D., Dec 4 2018, In : Cell Metabolism. 28, 6, p. 833-847.e8

Research output: Contribution to journal › Article

Mitochondrial Form Creatine Kinase

Phosphocreatine

Tyrosine

Phosphorylation

Breast Neoplasms

2017

16 Citations (Scopus)

A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia

Gojo, I., Beumer, J. H., Pratz, K. W., McDevitt, M. A., Baer, M. R., Blackford, A. L., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Levis, M. J., Dezern, A. E., Gladstone, D. E., Ji, J. J., Wang, L., Kinders, R. J., Pouquet, M., Ali-Walbi, I., Rudek, M. A., Poh, W. & 5 others, Herman, J. G., Karnitz, L. M., Kaufmann, S. H., Chen, A. & Karp, J. E., Feb 1 2017, In : Clinical Cancer Research. 23, 3, p. 697-706 10 p.

Research output: Contribution to journal › Article

temozolomide

Acute Myeloid Leukemia

Methylation

Phosphorylation

Polymers

13 Citations (Scopus)

A phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms, and chronic myelomonocytic leukemia

Pratz, K. W., Rudek, M. A., Gojo, I., Litzow, M. R., McDevitt, M. A., Ji, J., Karnitz, L. M., Herman, J. G., Kinders, R. J., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Gladstone, D. E., Levis, M. J., Tsai, H. L., Rosner, G., Chen, A., Kaufmann, S. H. & Karp, J. E., Feb 15 2017, In : Clinical Cancer Research. 23, 4, p. 899-907 9 p.

Research output: Contribution to journal › Article

Leukemia, Myelomonocytic, Chronic

Topotecan

Carboplatin

Leukemia

Neoplasms

9 Citations (Scopus)

Randomized phase II trial of cytosine arabinoside with and without the CHK1 inhibitor MK-8776 in relapsed and refractory acute myeloid leukemia

Webster, J. A., Tibes, R., Morris, L., Blackford, A. L., Litzow, M. R., Patnaik, M. M., Rosner, G. L., Gojo, I., Kinders, R., Wang, L., Doyle, L. A., Huntoon, C. J., Karnitz, L. M., Kaufmann, S. H., Karp, J. E. & Smith, B. D., Oct 1 2017, In : Leukemia Research. 61, p. 108-116 9 p.

Research output: Contribution to journal › Article

Cytarabine

Acute Myeloid Leukemia

DNA Damage

Cell Cycle Checkpoints

MK-8776

2016

12 Citations (Scopus)

Genomically incorporated 5-fluorouracil that escapes ung-initiated base excision repair blocks dna replication and activates homologous recombination

Huehls, A. M., Huntoon, C. J., Joshi, P. M., Baehr, C. A., Wagner, J. M., Wang, X., Lee, M. Y. & Karnitz, L. M., Jan 1 2016, In : Molecular Pharmacology. 89, 1, p. 53-62 10 p.

Research output: Contribution to journal › Article

Homologous Recombination

Fluorouracil

DNA Repair

Floxuridine

Uracil-DNA Glycosidase

4 Citations (Scopus)

Glycogen synthase kinase 3 (GSK-3)-mediated phosphorylation of uracil N-glycosylase 2 (UNG2) facilitates the repair of floxuridine-induced DNA lesions and promotes cell survival

Baehr, C. A., Huntoon, C. J., Hoang, S. M., Jerde, C. R. & Karnitz, L. M., Dec 23 2016, In : Journal of Biological Chemistry. 291, 52, p. 26875-26885 11 p.

Research output: Contribution to journal › Article

Uracil-DNA Glycosidase

Floxuridine

Glycogen Synthase Kinase 3

Phosphorylation

Cell Survival

2015

1 Citation (Scopus)

G2E3 attenuating replicative stress

Schmidt, F., Karnitz, L. M. & Dobbelstein, M., 2015, In : Aging. 7, 8, p. 527-528 2 p.

Research output: Contribution to journal › Article

Ubiquitin-Protein Ligases

DNA Replication

Neoplasms

62 Citations (Scopus)

Molecular pathways: Targeting ATR in cancer therapy

Karnitz, L. M. & Zou, L., Nov 1 2015, In : Clinical Cancer Research. 21, 21, p. 4780-4785 6 p.

Research output: Contribution to journal › Article

DNA Damage

Phosphotransferases

Telomere Homeostasis

Drug Therapy

Neoplasms

6 Citations (Scopus)

UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation

Jilani, Y., Lu, S., Lei, H., Karnitz, L. M. & Chadli, A., Feb 1 2015, In : Cancer Letters. 357, 1, p. 114-120 7 p.

Research output: Contribution to journal › Article

Centrosome

Cell Proliferation

Neoplasms

Aptitude

Myosins

2014

74 Citations (Scopus)

Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors

Joshi, P. M., Sutor, S. L., Huntoon, C. J. & Karnitz, L. M., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 9247-9253 7 p.

Research output: Contribution to journal › Article

Recombinational DNA Repair

Ovarian Neoplasms

Cisplatin

Catalyst activity

Repair

2013

79 Citations (Scopus)

ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status

Huntoon, C. J., Flatten, K. S., Wahner Hendrickson, A. E., Huehls, A. M., Sutor, S. L., Kaufmann, S. H. & Karnitz, L. M., Jun 15 2013, In : Cancer Research. 73, 12, p. 3683-3691 9 p.

Research output: Contribution to journal › Article

Ovarian Neoplasms

gemcitabine

Drug Therapy

Topotecan

Cisplatin

2012

15 Citations (Scopus)

A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma

Wahner Hendrickson, A. E., Oberg, A. L., Glaser, G., Camoriano, J. K., Peethambaram, P. P., Colon-Otero, G., Erlichman, C., Ivy, S. P., Kaufmann, S. H., Karnitz, L. M. & Haluska, P., Feb 2012, In : Gynecologic Oncology. 124, 2, p. 210-215 6 p.

Research output: Contribution to journal › Article

tanespimycin

gemcitabine

Carcinoma

Blood Cells

Neoplasms

35 Citations (Scopus)

Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro

Schenk, E. L., Koh, B. D., Flatten, K. S., Peterson, K. L., Parry, D., Hess, A. D., Smith, B. D., Karp, J. E., Karnitz, L. M. & Kaufmann, S. H., Oct 1 2012, In : Clinical Cancer Research. 18, 19, p. 5364-5373 10 p.

Research output: Contribution to journal › Article

Cytarabine

Acute Myeloid Leukemia

S Phase Cell Cycle Checkpoints

Immunoblotting

In Vitro Techniques

23 Citations (Scopus)

Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination

Huehls, A. M., Wagner, J. M., Huntoon, C. J. & Karnitz, L. M., Oct 2012, In : Molecular Pharmacology. 82, 4, p. 767-776 10 p.

Research output: Contribution to journal › Article

Drug Combinations

DNA Repair

Ovarian Neoplasms

Floxuridine

Homologous Recombination

2011

27 Citations (Scopus)

Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil

Geng, L., Huehls, A. M., Wagner, J. M., Huntoon, C. J. & Karnitz, L. M., Dec 15 2011, In : PLoS One. 6, 12, e28862.

Research output: Contribution to journal › Article

Floxuridine

fluorouracil

NAD ADP-ribosyltransferase

Poly(ADP-ribose) Polymerases

DNA repair

29 Citations (Scopus)

Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia

Kaufmann, S. H., Karp, J. E., Litzow, M. R., Mesa, R. A., Hogan, W., Steensma, D. P., Flatten, K. S., Loegering, D. A., Schneider, P. A., Peterson, K. L., Maurer, M. J., Smith, B. D., Greer, J., Chen, Y., Reid, J. M., Ivy, S. P., Ames, M. M., Adjei, A., Erlichman, C. & Karnitz, L. M., Nov 1 2011, In : Haematologica. 96, 11, p. 1619-1626 8 p.

Research output: Contribution to journal › Article

tanespimycin

Cytarabine

Leukemia

Pharmacology

HSP90 Heat-Shock Proteins

37 Citations (Scopus)

Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells

Huehls, A. M., Wagner, J. M., Huntoon, C. J., Geng, L., Erlichman, C., Patel, A. G., Kaufmann, S. H. & Karnitz, L. M., Jul 15 2011, In : Cancer Research. 71, 14, p. 4944-4954 11 p.

Research output: Contribution to journal › Article

Floxuridine

Poly(ADP-ribose) Polymerases

Fluorouracil

Ovarian Neoplasms

DNA Repair

2010

42 Citations (Scopus)

Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway

Huntoon, C. J., Nye, M. D., Geng, L., Peterson, K. L., Flatten, K. S., Haluska, P., Kaufmann, S. H. & Karnitz, L. M., Nov 1 2010, In : Cancer Research. 70, 21, p. 8642-8650 9 p.

Research output: Contribution to journal › Article

HSP90 Heat-Shock Proteins

tanespimycin

Neoplasms

Long-Acting Thyroid Stimulator

Phosphotransferases

65 Citations (Scopus)

RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network

Geng, L., Huntoon, C. J. & Karnitz, L. M., Oct 18 2010, In : Journal of Cell Biology. 191, 2, p. 249-257 9 p.

Research output: Contribution to journal › Article

Fanconi Anemia

Ubiquitination

Proliferating Cell Nuclear Antigen

DNA Repair

Ubiquitin-Protein Ligases

2009

78 Citations (Scopus)

Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival

Wagner, J. M. & Karnitz, L. M., Jul 2009, In : Molecular Pharmacology. 76, 1, p. 208-214 7 p.

Research output: Contribution to journal › Article

Cisplatin

DNA Damage

Cell Survival

oxaliplatin

Neoplasms

2008

11 Citations (Scopus)

Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I

McDonald, J. S., Galvez-Peralta, M., Dai, N. T., Loegering, D. A., Peterson, K. L., Meng, X. W., Karnitz, L. M. & Kaufmann, S. H., Jun 13 2008, In : Journal of Biological Chemistry. 283, 24, p. 16711-16722 12 p.

Research output: Contribution to journal › Article

Type I DNA Topoisomerase

Phosphorylation

Human Activities

DNA

Mitosis

9 Citations (Scopus)

Overcoming S-phase checkpoint-mediated resistance: Sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines

Gálvez-Peralta, M., Dai, N. T., Loegering, D. A., Flatten, K. S., Safgren, S. L., Wagner, J. M., Ames, M. M., Karnitz, L. M. & Kaufmann, S. H., Sep 2008, In : Molecular Pharmacology. 74, 3, p. 724-735 12 p.

Research output: Contribution to journal › Article

irinotecan

gemcitabine

S Phase Cell Cycle Checkpoints

Carcinoma

S Phase

46 Citations (Scopus)

Sonic Hedgehog signaling impairs ionizing radiation - Induced checkpoint activation and induces genomic instability

Leonard, J. M., Ye, H., Wetmore, C. & Karnitz, L. M., Nov 3 2008, In : Journal of Cell Biology. 183, 3, p. 385-391 7 p.

Research output: Contribution to journal › Article

Hedgehogs

Genomic Instability

Ionizing Radiation

Carcinogenesis

Cell Communication

2007

272 Citations (Scopus)

An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function

Scroggins, B. T., Robzyk, K., Wang, D., Marcu, M. G., Tsutsumi, S., Beebe, K., Cotter, R. J., Felts, S., Toft, D., Karnitz, L. M., Rosen, N. & Neckers, L., Jan 12 2007, In : Molecular Cell. 25, 1, p. 151-159 9 p.

Research output: Contribution to journal › Article

HSP90 Heat-Shock Proteins

Acetylation

Histone Deacetylase Inhibitors

Post Translational Protein Processing

Protein Binding

32 Citations (Scopus)

Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em.

Karnitz, L. M. & Felts, S. J., May 26 2007, In : Science's STKE : signal transduction knowledge environment. 2007, 385

Research output: Contribution to journal › Article

HSP90 Heat-Shock Proteins

Phosphotransferases

Yeast

Genes

Genome

22 Citations (Scopus)

Functioning of the Hsp90 machine in chaperoning checkpoint kinase 1 (Chk1) and the progesterone receptor (PR)

Felts, S. J., Karnitz, L. M. & Toft, D. O., Dec 2007, In : Cell Stress and Chaperones. 12, 4, p. 353-363 11 p.

Research output: Contribution to journal › Article

Progesterone Receptors

Phosphotransferases

Humulus

Protein Folding

Dissection

109 Citations (Scopus)

Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo

Matthews, D. J., Yakes, F. M., Chen, J., Tadano, M., Bornheim, L., Clary, D. O., Tai, A., Wagner, J. M., Miller, N., Kim, Y. D., Robertson, S., Murray, L. & Karnitz, L. M., Jan 1 2007, In : Cell Cycle. 6, 1, p. 104-110 7 p.

Research output: Contribution to journal › Article

gemcitabine

S Phase Cell Cycle Checkpoints

Tumors

Pharmacology

Phosphorylation

294 Citations (Scopus)

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1

Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K. I. & Karnitz, L. M., Jun 15 2007, In : Genes and Development. 21, 12, p. 1472-1477 6 p.

Research output: Contribution to journal › Article

Ataxia Telangiectasia Mutated Proteins

Proliferating Cell Nuclear Antigen

DNA Replication

Histones

Chromatin

2006

69 Citations (Scopus)

Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones

Arlander, S. J. H., Felts, S. J., Wagner, J. M., Stensgard, B., Toft, D. O. & Karnitz, L. M., Feb 3 2006, In : Journal of Biological Chemistry. 281, 5, p. 2989-2998 10 p.

Research output: Contribution to journal › Article

HSP90 Heat-Shock Proteins

Phosphotransferases

Checkpoint Kinase 1

Casein Kinase II

Humulus

2005

94 Citations (Scopus)

Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival

Karnitz, L. M., Flatten, K. S., Wagner, J. M., Loegering, D., McDonald, J. S., Arlander, S. J. H., Vroman, B. T., Thomas, M. B., Baek, Y. U., Hopkins, K. M., Lieberman, H. B., Chen, J., Cliby, W. A. & Kaufmann, S. H., Dec 2005, In : Molecular Pharmacology. 68, 6, p. 1636-1644 9 p.

Research output: Contribution to journal › Article

gemcitabine

Ataxia Telangiectasia

Cell Survival

Cytarabine

Phosphotransferases

93 Citations (Scopus)

Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine

Mesa, R. A., Loegering, D., Powell, H. L., Flatten, K., Arlander, S. J. H., Dai, N. T., Heldebrant, M. P., Vroman, B. T., Smith, B. D., Karp, J. E., Ten Eyck, C. J., Erlichman, C., Kaufmann, S. H. & Karnitz, L. M., Jul 1 2005, In : Blood. 106, 1, p. 318-327 10 p.

Research output: Contribution to journal › Article

tanespimycin

HSP90 Heat-Shock Proteins

Cytarabine

Acute Myeloid Leukemia

Phosphotransferases

86 Citations (Scopus)

The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons

Flatten, K., Dai, N. T., Vroman, B. T., Loegering, D., Erlichman, C., Karnitz, L. M. & Kaufmann, S. H., Apr 8 2005, In : Journal of Biological Chemistry. 280, 14, p. 14349-14355 7 p.

Research output: Contribution to journal › Article

irinotecan

Type I DNA Topoisomerase

Poisons

Ataxia Telangiectasia

Phosphotransferases

2004

213 Citations (Scopus)

Dial 9-1-1 for DNA damage: The Rad9-Hus1-Rad1 (9-1-1) clamp complex

Parrilla-Castellar, E. R., Arlander, S. J. H. & Karnitz, L. M., Aug 2004, In : DNA Repair. 3, 8-9, p. 1009-1014 6 p.

Research output: Contribution to journal › Article

Clamping devices

DNA Repair

DNA Damage

Proliferating Cell Nuclear Antigen

DNA

Purification and identification of protein complexes that control the cell cycle.

Burtelow, M. A., Podust, V. N. & Karnitz, L. M., 2004, In : Methods in molecular biology (Clifton, N.J.). 241, p. 247-253 7 p.

Research output: Contribution to journal › Article

Cell Cycle Proteins

Baculoviridae

Cell Cycle Checkpoints

Glutathione Transferase

Biochemistry

32 Citations (Scopus)

Rad9 Protects Cells from Topoisomerase Poison-induced Cell Death

Loegering, D., Arlander, S. J. H., McDonald, J. S., Vroman, B. T., Roos-Mattjus, P., Hopkins, K. M., Lieberman, H. B., Karnitz, L. M. & Kaufmann, S. H., Apr 30 2004, In : Journal of Biological Chemistry. 279, 18, p. 18641-18647 7 p.

Research output: Contribution to journal › Article

Poisons

Cell death

Embryonic Stem Cells

Stem cells

Cytarabine

35 Citations (Scopus)

S-peptide epitope tagging for protein purification, expression monitoring, and localization in mammalian cells

McDonald, J. S., Lee, S. H., Meng, X. W., Vroman, B. T., Kaufmann, S. H. & Karnitz, L. M., Nov 2004, In : BioTechniques. 37, 5, p. 835-839 5 p.

Research output: Contribution to journal › Article

Purification

Epitopes

Cells

Peptides

Monitoring

2003

35 Citations (Scopus)

Cloning and characterization of hCTF18, hCTF8, and hDCC1: Human homologs of an Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment

Merkle, C. J., Karnitz, L. M., Henry-Sánchez, J. T. & Chen, J., Aug 8 2003, In : Journal of Biological Chemistry. 278, 32, p. 30051-30056 6 p.

Research output: Contribution to journal › Article

Replication Protein C

Chromatids

Cloning

Yeast

Saccharomyces cerevisiae

57 Citations (Scopus)

Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin

Parrilla-Castellar, E. R. & Karnitz, L. M., Nov 14 2003, In : Journal of Biological Chemistry. 278, 46, p. 45507-45511 5 p.

Research output: Contribution to journal › Article

Mutagens

DNA-Directed DNA Polymerase

DNA Damage

Chromatin

DNA

142 Citations (Scopus)

Hsp90 Inhibition Depletes Chk1 and Sensitizes Tumor Cells to Replication Stress

Arlander, S. J. H., Eapen, A. K., Vroman, B. T., McDonald, R., Toft, D. O. & Karnitz, L. M., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52572-52577 6 p.

Research output: Contribution to journal › Article

tanespimycin

Tumors

Cells

gemcitabine

S Phase

12 Citations (Scopus)

Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene

Dufault, V. M., Oestreich, A. J., Vroman, B. T. & Karnitz, L. M., Dec 2003, In : Genomics. 82, 6, p. 644-651 8 p.

Research output: Contribution to journal › Article

Mutagens

Proliferating Cell Nuclear Antigen

Immunoprecipitation

Northern Blotting

Genes

97 Citations (Scopus)

Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint Signaling

Roos-Mattjus, P., Hopkins, K. M., Oestreich, A. J., Vroman, B. T., Johnson, K. L., Naylor, S., Lieberman, H. B. & Karnitz, L. M., Jul 4 2003, In : Journal of Biological Chemistry. 278, 27, p. 24428-24437 10 p.

Research output: Contribution to journal › Article

Phosphorylation

Mutagens

Ionizing radiation

Ionizing Radiation

Hydroxyurea

2002

72 Citations (Scopus)

Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event

Roos-Mattjus, P., Vroman, B. T., Burtelow, M. A., Rauen, M., Eapen, A. K. & Karnitz, L. M., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 43809-43812 4 p.

Research output: Contribution to journal › Article

Mutagens

Chromatin

Association reactions

Replication Protein C

DNA

2001

107 Citations (Scopus)

Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex

Burtelow, M. A., Roos-Mattjus, P. M. K., Rauen, M., Babendure, J. R. & Karnitz, L. M., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 25903-25909 7 p.

Research output: Contribution to journal › Article

DNA Damage

DNA

Proteins

Cells

Cell Cycle Checkpoints

2000

584 Citations (Scopus)

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

Sekulic, A. D., Hudson, C. C., Homme, J. L., Yin, P., Otterness, D. M., Karnitz, L. M. & Abraham, R. T., Jul 1 2000, In : Cancer Research. 60, 13, p. 3504-3513 10 p.

Research output: Contribution to journal › Article

1-Phosphatidylinositol 4-Kinase

Sirolimus

Mitogens

Phosphorylation

Protein Kinases

96 Citations (Scopus)

Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage

Burtelow, M. A., Kaufmann, S. H. & Karnitz, L. M., Aug 25 2000, In : Journal of Biological Chemistry. 275, 34, p. 26343-26348 6 p.

Research output: Contribution to journal › Article

DNA Damage

DNA

Genes

Mammals

Hydroxyurea

167 Citations (Scopus)

The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3- kinase-dependent survival signaling cascade

Rust, C., Karnitz, L. M., Paya, C. V., Moscat, J., Simari, R. D. & Gores, G. J., Jun 30 2000, In : Journal of Biological Chemistry. 275, 26, p. 20210-20216 7 p.

Research output: Contribution to journal › Article

Taurochenodeoxycholic Acid

Phosphatidylinositol 3-Kinase

Bile Acids and Salts

Glycochenodeoxycholic Acid

Chenodeoxycholic Acid

81 Citations (Scopus)

The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9

Rauen, M., Burtelow, M. A., Dufault, V. M. & Karnitz, L. M., Sep 22 2000, In : Journal of Biological Chemistry. 275, 38, p. 29767-29771 5 p.

Research output: Contribution to journal › Article

Clamping devices

Proliferating Cell Nuclear Antigen

Replication Protein C

DNA Damage

Loaders

301 Citations (Scopus)

The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

Busby, E. C., Leistritz, D. F., Abraham, R. T., Karnitz, L. M. & Sarkaria, J. N., Apr 15 2000, In : Cancer Research. 60, 8, p. 2108-2112 5 p.

Research output: Contribution to journal › Article

Radiation-Sensitizing Agents

DNA Damage

Phosphotransferases

Antineoplastic Agents

cdc25 Phosphatases