Research Output per year
Research Output 1984 2019
- 6498 Citations
- 41 Scopus h-Index
- 76 Article
- 1 - 50 out of 76 results
- Publication Year, Title (descending)
Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo
Vincelette, N. D., Ding, H., Huehls, A. M., Flatten, K. S., Kelly, R. L., Kohorst, M. A., Webster, J., Hess, A. D., Pratz, K. W., Karnitz, L. M. & Kaufmann, S. H., Dec 1 2019, In : Scientific reports. 9, 1, 3617.Research output: Contribution to journal › Article
ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
Kanakkanthara, A., Huntoon, C. J., Hou, X., Zhang, M., Heinzen, E. P., O’Brien, D. R., Oberg, A. L., John Weroha, S., Kaufmann, S. H. & Karnitz, L. M., Dec 1 2019, In : Nature communications. 10, 1, 4632.Research output: Contribution to journal › Article
Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity
Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye-Agyeman, F., Gonsalves, W., Lou, Z., Karnitz, L. M., Goetz, M. P. & Hitosugi, T. D., Feb 6 2018, In : Cell Reports. 22, 6, p. 1365-1373 9 p.Research output: Contribution to journal › Article
Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway
Kurmi, K., Hitosugi, S., Yu, J., Boakye-Agyeman, F., Wiese, E. K., Larson, T. R., Dai, Q., Machida, Y., Lou, Z., Wang, L. M., Boughey, J. C., Kaufmann, S. H., Goetz, M. P., Karnitz, L. M. & Hitosugi, T. D., Dec 4 2018, In : Cell Metabolism. 28, 6, p. 833-847.e8Research output: Contribution to journal › Article
A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia
Gojo, I., Beumer, J. H., Pratz, K. W., McDevitt, M. A., Baer, M. R., Blackford, A. L., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Levis, M. J., Dezern, A. E., Gladstone, D. E., Ji, J. J., Wang, L., Kinders, R. J., Pouquet, M., Ali-Walbi, I., Rudek, M. A., Poh, W. & 5 others, , Feb 1 2017, In : Clinical Cancer Research. 23, 3, p. 697-706 10 p.Research output: Contribution to journal › Article
A phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms, and chronic myelomonocytic leukemia
Pratz, K. W., Rudek, M. A., Gojo, I., Litzow, M. R., McDevitt, M. A., Ji, J., Karnitz, L. M., Herman, J. G., Kinders, R. J., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Gladstone, D. E., Levis, M. J., Tsai, H. L., Rosner, G., Chen, A., Kaufmann, S. H. & Karp, J. E., Feb 15 2017, In : Clinical Cancer Research. 23, 4, p. 899-907 9 p.Research output: Contribution to journal › Article
Randomized phase II trial of cytosine arabinoside with and without the CHK1 inhibitor MK-8776 in relapsed and refractory acute myeloid leukemia
Webster, J. A., Tibes, R., Morris, L., Blackford, A. L., Litzow, M. R., Patnaik, M. M., Rosner, G. L., Gojo, I., Kinders, R., Wang, L., Doyle, L. A., Huntoon, C. J., Karnitz, L. M., Kaufmann, S. H., Karp, J. E. & Smith, B. D., Oct 1 2017, In : Leukemia Research. 61, p. 108-116 9 p.Research output: Contribution to journal › Article
Genomically incorporated 5-fluorouracil that escapes ung-initiated base excision repair blocks dna replication and activates homologous recombination
Huehls, A. M., Huntoon, C. J., Joshi, P. M., Baehr, C. A., Wagner, J. M., Wang, X., Lee, M. Y. & Karnitz, L. M., Jan 1 2016, In : Molecular Pharmacology. 89, 1, p. 53-62 10 p.Research output: Contribution to journal › Article
Glycogen synthase kinase 3 (GSK-3)-mediated phosphorylation of uracil N-glycosylase 2 (UNG2) facilitates the repair of floxuridine-induced DNA lesions and promotes cell survival
Baehr, C. A., Huntoon, C. J., Hoang, S. M., Jerde, C. R. & Karnitz, L. M., Dec 23 2016, In : Journal of Biological Chemistry. 291, 52, p. 26875-26885 11 p.Research output: Contribution to journal › Article
G2E3 attenuating replicative stress
Schmidt, F., Karnitz, L. M. & Dobbelstein, M., 2015, In : Aging. 7, 8, p. 527-528 2 p.Research output: Contribution to journal › Article
Molecular pathways: Targeting ATR in cancer therapy
Karnitz, L. M. & Zou, L., Nov 1 2015, In : Clinical Cancer Research. 21, 21, p. 4780-4785 6 p.Research output: Contribution to journal › Article
UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation
Jilani, Y., Lu, S., Lei, H., Karnitz, L. M. & Chadli, A., Feb 1 2015, In : Cancer Letters. 357, 1, p. 114-120 7 p.Research output: Contribution to journal › Article
Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors
Joshi, P. M., Sutor, S. L., Huntoon, C. J. & Karnitz, L. M., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 9247-9253 7 p.Research output: Contribution to journal › Article
ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status
Huntoon, C. J., Flatten, K. S., Wahner Hendrickson, A. E., Huehls, A. M., Sutor, S. L., Kaufmann, S. H. & Karnitz, L. M., Jun 15 2013, In : Cancer Research. 73, 12, p. 3683-3691 9 p.Research output: Contribution to journal › Article
A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma
Wahner Hendrickson, A. E., Oberg, A. L., Glaser, G., Camoriano, J. K., Peethambaram, P. P., Colon-Otero, G., Erlichman, C., Ivy, S. P., Kaufmann, S. H., Karnitz, L. M. & Haluska, P., Feb 2012, In : Gynecologic Oncology. 124, 2, p. 210-215 6 p.Research output: Contribution to journal › Article
Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro
Schenk, E. L., Koh, B. D., Flatten, K. S., Peterson, K. L., Parry, D., Hess, A. D., Smith, B. D., Karp, J. E., Karnitz, L. M. & Kaufmann, S. H., Oct 1 2012, In : Clinical Cancer Research. 18, 19, p. 5364-5373 10 p.Research output: Contribution to journal › Article
Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination
Huehls, A. M., Wagner, J. M., Huntoon, C. J. & Karnitz, L. M., Oct 2012, In : Molecular Pharmacology. 82, 4, p. 767-776 10 p.Research output: Contribution to journal › Article
Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil
Geng, L., Huehls, A. M., Wagner, J. M., Huntoon, C. J. & Karnitz, L. M., Dec 15 2011, In : PLoS One. 6, 12, e28862.Research output: Contribution to journal › Article
Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia
Kaufmann, S. H., Karp, J. E., Litzow, M. R., Mesa, R. A., Hogan, W., Steensma, D. P., Flatten, K. S., Loegering, D. A., Schneider, P. A., Peterson, K. L., Maurer, M. J., Smith, B. D., Greer, J., Chen, Y., Reid, J. M., Ivy, S. P., Ames, M. M., Adjei, A., Erlichman, C. & Karnitz, L. M., Nov 1 2011, In : Haematologica. 96, 11, p. 1619-1626 8 p.Research output: Contribution to journal › Article
Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells
Huehls, A. M., Wagner, J. M., Huntoon, C. J., Geng, L., Erlichman, C., Patel, A. G., Kaufmann, S. H. & Karnitz, L. M., Jul 15 2011, In : Cancer Research. 71, 14, p. 4944-4954 11 p.Research output: Contribution to journal › Article
Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway
Huntoon, C. J., Nye, M. D., Geng, L., Peterson, K. L., Flatten, K. S., Haluska, P., Kaufmann, S. H. & Karnitz, L. M., Nov 1 2010, In : Cancer Research. 70, 21, p. 8642-8650 9 p.Research output: Contribution to journal › Article
RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network
Geng, L., Huntoon, C. J. & Karnitz, L. M., Oct 18 2010, In : Journal of Cell Biology. 191, 2, p. 249-257 9 p.Research output: Contribution to journal › Article
Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival
Wagner, J. M. & Karnitz, L. M., Jul 2009, In : Molecular Pharmacology. 76, 1, p. 208-214 7 p.Research output: Contribution to journal › Article
Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I
McDonald, J. S., Galvez-Peralta, M., Dai, N. T., Loegering, D. A., Peterson, K. L., Meng, X. W., Karnitz, L. M. & Kaufmann, S. H., Jun 13 2008, In : Journal of Biological Chemistry. 283, 24, p. 16711-16722 12 p.Research output: Contribution to journal › Article
Overcoming S-phase checkpoint-mediated resistance: Sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines
Gálvez-Peralta, M., Dai, N. T., Loegering, D. A., Flatten, K. S., Safgren, S. L., Wagner, J. M., Ames, M. M., Karnitz, L. M. & Kaufmann, S. H., Sep 2008, In : Molecular Pharmacology. 74, 3, p. 724-735 12 p.Research output: Contribution to journal › Article
Sonic Hedgehog signaling impairs ionizing radiation - Induced checkpoint activation and induces genomic instability
Leonard, J. M., Ye, H., Wetmore, C. & Karnitz, L. M., Nov 3 2008, In : Journal of Cell Biology. 183, 3, p. 385-391 7 p.Research output: Contribution to journal › Article
An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function
Scroggins, B. T., Robzyk, K., Wang, D., Marcu, M. G., Tsutsumi, S., Beebe, K., Cotter, R. J., Felts, S., Toft, D., Karnitz, L. M., Rosen, N. & Neckers, L., Jan 12 2007, In : Molecular Cell. 25, 1, p. 151-159 9 p.Research output: Contribution to journal › Article
Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em.
Karnitz, L. M. & Felts, S. J., May 26 2007, In : Science's STKE : signal transduction knowledge environment. 2007, 385Research output: Contribution to journal › Article
Functioning of the Hsp90 machine in chaperoning checkpoint kinase 1 (Chk1) and the progesterone receptor (PR)
Felts, S. J., Karnitz, L. M. & Toft, D. O., Dec 2007, In : Cell Stress and Chaperones. 12, 4, p. 353-363 11 p.Research output: Contribution to journal › Article
Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo
Matthews, D. J., Yakes, F. M., Chen, J., Tadano, M., Bornheim, L., Clary, D. O., Tai, A., Wagner, J. M., Miller, N., Kim, Y. D., Robertson, S., Murray, L. & Karnitz, L. M., Jan 1 2007, In : Cell Cycle. 6, 1, p. 104-110 7 p.Research output: Contribution to journal › Article
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K. I. & Karnitz, L. M., Jun 15 2007, In : Genes and Development. 21, 12, p. 1472-1477 6 p.Research output: Contribution to journal › Article
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones
Arlander, S. J. H., Felts, S. J., Wagner, J. M., Stensgard, B., Toft, D. O. & Karnitz, L. M., Feb 3 2006, In : Journal of Biological Chemistry. 281, 5, p. 2989-2998 10 p.Research output: Contribution to journal › Article
Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival
Karnitz, L. M., Flatten, K. S., Wagner, J. M., Loegering, D., McDonald, J. S., Arlander, S. J. H., Vroman, B. T., Thomas, M. B., Baek, Y. U., Hopkins, K. M., Lieberman, H. B., Chen, J., Cliby, W. A. & Kaufmann, S. H., Dec 2005, In : Molecular Pharmacology. 68, 6, p. 1636-1644 9 p.Research output: Contribution to journal › Article
Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine
Mesa, R. A., Loegering, D., Powell, H. L., Flatten, K., Arlander, S. J. H., Dai, N. T., Heldebrant, M. P., Vroman, B. T., Smith, B. D., Karp, J. E., Ten Eyck, C. J., Erlichman, C., Kaufmann, S. H. & Karnitz, L. M., Jul 1 2005, In : Blood. 106, 1, p. 318-327 10 p.Research output: Contribution to journal › Article
The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons
Flatten, K., Dai, N. T., Vroman, B. T., Loegering, D., Erlichman, C., Karnitz, L. M. & Kaufmann, S. H., Apr 8 2005, In : Journal of Biological Chemistry. 280, 14, p. 14349-14355 7 p.Research output: Contribution to journal › Article
Dial 9-1-1 for DNA damage: The Rad9-Hus1-Rad1 (9-1-1) clamp complex
Parrilla-Castellar, E. R., Arlander, S. J. H. & Karnitz, L. M., Aug 2004, In : DNA Repair. 3, 8-9, p. 1009-1014 6 p.Research output: Contribution to journal › Article
Purification and identification of protein complexes that control the cell cycle.
Burtelow, M. A., Podust, V. N. & Karnitz, L. M., 2004, In : Methods in molecular biology (Clifton, N.J.). 241, p. 247-253 7 p.Research output: Contribution to journal › Article
Rad9 Protects Cells from Topoisomerase Poison-induced Cell Death
Loegering, D., Arlander, S. J. H., McDonald, J. S., Vroman, B. T., Roos-Mattjus, P., Hopkins, K. M., Lieberman, H. B., Karnitz, L. M. & Kaufmann, S. H., Apr 30 2004, In : Journal of Biological Chemistry. 279, 18, p. 18641-18647 7 p.Research output: Contribution to journal › Article
S-peptide epitope tagging for protein purification, expression monitoring, and localization in mammalian cells
McDonald, J. S., Lee, S. H., Meng, X. W., Vroman, B. T., Kaufmann, S. H. & Karnitz, L. M., Nov 2004, In : BioTechniques. 37, 5, p. 835-839 5 p.Research output: Contribution to journal › Article
Cloning and characterization of hCTF18, hCTF8, and hDCC1: Human homologs of an Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment
Merkle, C. J., Karnitz, L. M., Henry-Sánchez, J. T. & Chen, J., Aug 8 2003, In : Journal of Biological Chemistry. 278, 32, p. 30051-30056 6 p.Research output: Contribution to journal › Article
Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin
Parrilla-Castellar, E. R. & Karnitz, L. M., Nov 14 2003, In : Journal of Biological Chemistry. 278, 46, p. 45507-45511 5 p.Research output: Contribution to journal › Article
Hsp90 Inhibition Depletes Chk1 and Sensitizes Tumor Cells to Replication Stress
Arlander, S. J. H., Eapen, A. K., Vroman, B. T., McDonald, R., Toft, D. O. & Karnitz, L. M., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52572-52577 6 p.Research output: Contribution to journal › Article
Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene
Dufault, V. M., Oestreich, A. J., Vroman, B. T. & Karnitz, L. M., Dec 2003, In : Genomics. 82, 6, p. 644-651 8 p.Research output: Contribution to journal › Article
Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint Signaling
Roos-Mattjus, P., Hopkins, K. M., Oestreich, A. J., Vroman, B. T., Johnson, K. L., Naylor, S., Lieberman, H. B. & Karnitz, L. M., Jul 4 2003, In : Journal of Biological Chemistry. 278, 27, p. 24428-24437 10 p.Research output: Contribution to journal › Article
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event
Roos-Mattjus, P., Vroman, B. T., Burtelow, M. A., Rauen, M., Eapen, A. K. & Karnitz, L. M., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 43809-43812 4 p.Research output: Contribution to journal › Article
Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex
Burtelow, M. A., Roos-Mattjus, P. M. K., Rauen, M., Babendure, J. R. & Karnitz, L. M., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 25903-25909 7 p.Research output: Contribution to journal › Article
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
Sekulic, A. D., Hudson, C. C., Homme, J. L., Yin, P., Otterness, D. M., Karnitz, L. M. & Abraham, R. T., Jul 1 2000, In : Cancer Research. 60, 13, p. 3504-3513 10 p.Research output: Contribution to journal › Article
Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage
Burtelow, M. A., Kaufmann, S. H. & Karnitz, L. M., Aug 25 2000, In : Journal of Biological Chemistry. 275, 34, p. 26343-26348 6 p.Research output: Contribution to journal › Article
The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3- kinase-dependent survival signaling cascade
Rust, C., Karnitz, L. M., Paya, C. V., Moscat, J., Simari, R. D. & Gores, G. J., Jun 30 2000, In : Journal of Biological Chemistry. 275, 26, p. 20210-20216 7 p.Research output: Contribution to journal › Article
The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9
Rauen, M., Burtelow, M. A., Dufault, V. M. & Karnitz, L. M., Sep 22 2000, In : Journal of Biological Chemistry. 275, 38, p. 29767-29771 5 p.Research output: Contribution to journal › Article