Larry M Karnitz, PhD

  • 6421 Citations
  • 41 Scopus h-Index
1984 …2021
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Research Output 1984 2019

  • 6421 Citations
  • 41 Scopus h-Index
  • 75 Article
2019

Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo

Vincelette, N. D., Ding, H., Huehls, A. M., Flatten, K. S., Kelly, R. L., Kohorst, M. A., Webster, J., Hess, A. D., Pratz, K. W., Karnitz, L. M. & Kaufmann, S. H., Dec 1 2019, In : Scientific reports. 9, 1, 3617.

Research output: Contribution to journalArticle

Open Access
Acute Myeloid Leukemia
Cytarabine
Daunorubicin
G2 Phase Cell Cycle Checkpoints
In Vitro Techniques
2018
8 Citations (Scopus)

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye-Agyeman, F., Gonsalves, W., Lou, Z., Karnitz, L. M., Goetz, M. P. & Hitosugi, T. D., Feb 6 2018, In : Cell Reports. 22, 6, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

Carnitine O-Palmitoyltransferase
Lysine
Phosphopyruvate Hydratase
Isotope Labeling
Mutation
4 Citations (Scopus)

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

Kurmi, K., Hitosugi, S., Yu, J., Boakye-Agyeman, F., Wiese, E. K., Larson, T. R., Dai, Q., Machida, Y., Lou, Z., Wang, L. M., Boughey, J. C., Kaufmann, S. H., Goetz, M. P., Karnitz, L. M. & Hitosugi, T. D., Dec 4 2018, In : Cell Metabolism. 28, 6, p. 833-847.e8

Research output: Contribution to journalArticle

Mitochondrial Form Creatine Kinase
Phosphocreatine
Tyrosine
Phosphorylation
Breast Neoplasms
2017
16 Citations (Scopus)

A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia

Gojo, I., Beumer, J. H., Pratz, K. W., McDevitt, M. A., Baer, M. R., Blackford, A. L., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Levis, M. J., Dezern, A. E., Gladstone, D. E., Ji, J. J., Wang, L., Kinders, R. J., Pouquet, M., Ali-Walbi, I., Rudek, M. A., Poh, W. & 5 others, Herman, J. G., Karnitz, L. M., Kaufmann, S. H., Chen, A. & Karp, J. E., Feb 1 2017, In : Clinical Cancer Research. 23, 3, p. 697-706 10 p.

Research output: Contribution to journalArticle

temozolomide
Acute Myeloid Leukemia
Methylation
Phosphorylation
Polymers
13 Citations (Scopus)

A phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms, and chronic myelomonocytic leukemia

Pratz, K. W., Rudek, M. A., Gojo, I., Litzow, M. R., McDevitt, M. A., Ji, J., Karnitz, L. M., Herman, J. G., Kinders, R. J., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Gladstone, D. E., Levis, M. J., Tsai, H. L., Rosner, G., Chen, A., Kaufmann, S. H. & Karp, J. E., Feb 15 2017, In : Clinical Cancer Research. 23, 4, p. 899-907 9 p.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Topotecan
Carboplatin
Leukemia
Neoplasms
9 Citations (Scopus)

Randomized phase II trial of cytosine arabinoside with and without the CHK1 inhibitor MK-8776 in relapsed and refractory acute myeloid leukemia

Webster, J. A., Tibes, R., Morris, L., Blackford, A. L., Litzow, M. R., Patnaik, M. M., Rosner, G. L., Gojo, I., Kinders, R., Wang, L., Doyle, L. A., Huntoon, C. J., Karnitz, L. M., Kaufmann, S. H., Karp, J. E. & Smith, B. D., Oct 1 2017, In : Leukemia Research. 61, p. 108-116 9 p.

Research output: Contribution to journalArticle

Cytarabine
Acute Myeloid Leukemia
DNA Damage
Cell Cycle Checkpoints
MK-8776
2016
12 Citations (Scopus)

Genomically incorporated 5-fluorouracil that escapes ung-initiated base excision repair blocks dna replication and activates homologous recombination

Huehls, A. M., Huntoon, C. J., Joshi, P. M., Baehr, C. A., Wagner, J. M., Wang, X., Lee, M. Y. & Karnitz, L. M., Jan 1 2016, In : Molecular Pharmacology. 89, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

Homologous Recombination
Fluorouracil
DNA Repair
Floxuridine
Uracil-DNA Glycosidase
4 Citations (Scopus)

Glycogen synthase kinase 3 (GSK-3)-mediated phosphorylation of uracil N-glycosylase 2 (UNG2) facilitates the repair of floxuridine-induced DNA lesions and promotes cell survival

Baehr, C. A., Huntoon, C. J., Hoang, S. M., Jerde, C. R. & Karnitz, L. M., Dec 23 2016, In : Journal of Biological Chemistry. 291, 52, p. 26875-26885 11 p.

Research output: Contribution to journalArticle

Uracil-DNA Glycosidase
Floxuridine
Glycogen Synthase Kinase 3
Phosphorylation
Cell Survival
2015
1 Citation (Scopus)

G2E3 attenuating replicative stress

Schmidt, F., Karnitz, L. M. & Dobbelstein, M., 2015, In : Aging. 7, 8, p. 527-528 2 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
DNA Replication
Neoplasms
62 Citations (Scopus)

Molecular pathways: Targeting ATR in cancer therapy

Karnitz, L. M. & Zou, L., Nov 1 2015, In : Clinical Cancer Research. 21, 21, p. 4780-4785 6 p.

Research output: Contribution to journalArticle

DNA Damage
Phosphotransferases
Telomere Homeostasis
Drug Therapy
Neoplasms
6 Citations (Scopus)

UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation

Jilani, Y., Lu, S., Lei, H., Karnitz, L. M. & Chadli, A., Feb 1 2015, In : Cancer Letters. 357, 1, p. 114-120 7 p.

Research output: Contribution to journalArticle

Centrosome
Cell Proliferation
Neoplasms
Aptitude
Myosins
2014
74 Citations (Scopus)
Recombinational DNA Repair
Ovarian Neoplasms
Cisplatin
Catalyst activity
Repair
2013
79 Citations (Scopus)

ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status

Huntoon, C. J., Flatten, K. S., Wahner Hendrickson, A. E., Huehls, A. M., Sutor, S. L., Kaufmann, S. H. & Karnitz, L. M., Jun 15 2013, In : Cancer Research. 73, 12, p. 3683-3691 9 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
gemcitabine
Drug Therapy
Topotecan
Cisplatin
2012
15 Citations (Scopus)

A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma

Wahner Hendrickson, A. E., Oberg, A. L., Glaser, G., Camoriano, J. K., Peethambaram, P. P., Colon-Otero, G., Erlichman, C., Ivy, S. P., Kaufmann, S. H., Karnitz, L. M. & Haluska, P., Feb 2012, In : Gynecologic Oncology. 124, 2, p. 210-215 6 p.

Research output: Contribution to journalArticle

tanespimycin
gemcitabine
Carcinoma
Blood Cells
Neoplasms
35 Citations (Scopus)

Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro

Schenk, E. L., Koh, B. D., Flatten, K. S., Peterson, K. L., Parry, D., Hess, A. D., Smith, B. D., Karp, J. E., Karnitz, L. M. & Kaufmann, S. H., Oct 1 2012, In : Clinical Cancer Research. 18, 19, p. 5364-5373 10 p.

Research output: Contribution to journalArticle

Cytarabine
Acute Myeloid Leukemia
S Phase Cell Cycle Checkpoints
Immunoblotting
In Vitro Techniques
23 Citations (Scopus)

Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination

Huehls, A. M., Wagner, J. M., Huntoon, C. J. & Karnitz, L. M., Oct 2012, In : Molecular Pharmacology. 82, 4, p. 767-776 10 p.

Research output: Contribution to journalArticle

Drug Combinations
DNA Repair
Ovarian Neoplasms
Floxuridine
Homologous Recombination
2011
27 Citations (Scopus)

Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil

Geng, L., Huehls, A. M., Wagner, J. M., Huntoon, C. J. & Karnitz, L. M., Dec 15 2011, In : PLoS One. 6, 12, e28862.

Research output: Contribution to journalArticle

Floxuridine
fluorouracil
NAD ADP-ribosyltransferase
Poly(ADP-ribose) Polymerases
DNA repair
29 Citations (Scopus)

Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia

Kaufmann, S. H., Karp, J. E., Litzow, M. R., Mesa, R. A., Hogan, W., Steensma, D. P., Flatten, K. S., Loegering, D. A., Schneider, P. A., Peterson, K. L., Maurer, M. J., Smith, B. D., Greer, J., Chen, Y., Reid, J. M., Ivy, S. P., Ames, M. M., Adjei, A., Erlichman, C. & Karnitz, L. M., Nov 1 2011, In : Haematologica. 96, 11, p. 1619-1626 8 p.

Research output: Contribution to journalArticle

tanespimycin
Cytarabine
Leukemia
Pharmacology
HSP90 Heat-Shock Proteins
37 Citations (Scopus)

Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells

Huehls, A. M., Wagner, J. M., Huntoon, C. J., Geng, L., Erlichman, C., Patel, A. G., Kaufmann, S. H. & Karnitz, L. M., Jul 15 2011, In : Cancer Research. 71, 14, p. 4944-4954 11 p.

Research output: Contribution to journalArticle

Floxuridine
Poly(ADP-ribose) Polymerases
Fluorouracil
Ovarian Neoplasms
DNA Repair
2010
42 Citations (Scopus)

Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway

Huntoon, C. J., Nye, M. D., Geng, L., Peterson, K. L., Flatten, K. S., Haluska, P., Kaufmann, S. H. & Karnitz, L. M., Nov 1 2010, In : Cancer Research. 70, 21, p. 8642-8650 9 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
tanespimycin
Neoplasms
Long-Acting Thyroid Stimulator
Phosphotransferases
65 Citations (Scopus)

RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network

Geng, L., Huntoon, C. J. & Karnitz, L. M., Oct 18 2010, In : Journal of Cell Biology. 191, 2, p. 249-257 9 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Ubiquitination
Proliferating Cell Nuclear Antigen
DNA Repair
Ubiquitin-Protein Ligases
2009
78 Citations (Scopus)
Cisplatin
DNA Damage
Cell Survival
oxaliplatin
Neoplasms
2008
11 Citations (Scopus)

Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I

McDonald, J. S., Galvez-Peralta, M., Dai, N. T., Loegering, D. A., Peterson, K. L., Meng, X. W., Karnitz, L. M. & Kaufmann, S. H., Jun 13 2008, In : Journal of Biological Chemistry. 283, 24, p. 16711-16722 12 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Phosphorylation
Human Activities
DNA
Mitosis
9 Citations (Scopus)

Overcoming S-phase checkpoint-mediated resistance: Sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines

Gálvez-Peralta, M., Dai, N. T., Loegering, D. A., Flatten, K. S., Safgren, S. L., Wagner, J. M., Ames, M. M., Karnitz, L. M. & Kaufmann, S. H., Sep 2008, In : Molecular Pharmacology. 74, 3, p. 724-735 12 p.

Research output: Contribution to journalArticle

irinotecan
gemcitabine
S Phase Cell Cycle Checkpoints
Carcinoma
S Phase
46 Citations (Scopus)

Sonic Hedgehog signaling impairs ionizing radiation - Induced checkpoint activation and induces genomic instability

Leonard, J. M., Ye, H., Wetmore, C. & Karnitz, L. M., Nov 3 2008, In : Journal of Cell Biology. 183, 3, p. 385-391 7 p.

Research output: Contribution to journalArticle

Hedgehogs
Genomic Instability
Ionizing Radiation
Carcinogenesis
Cell Communication
2007
272 Citations (Scopus)

An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function

Scroggins, B. T., Robzyk, K., Wang, D., Marcu, M. G., Tsutsumi, S., Beebe, K., Cotter, R. J., Felts, S., Toft, D., Karnitz, L. M., Rosen, N. & Neckers, L., Jan 12 2007, In : Molecular Cell. 25, 1, p. 151-159 9 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Acetylation
Histone Deacetylase Inhibitors
Post Translational Protein Processing
Protein Binding
32 Citations (Scopus)

Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em.

Karnitz, L. M. & Felts, S. J., May 26 2007, In : Science's STKE : signal transduction knowledge environment. 2007, 385

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Phosphotransferases
Yeast
Genes
Genome
22 Citations (Scopus)

Functioning of the Hsp90 machine in chaperoning checkpoint kinase 1 (Chk1) and the progesterone receptor (PR)

Felts, S. J., Karnitz, L. M. & Toft, D. O., Dec 2007, In : Cell Stress and Chaperones. 12, 4, p. 353-363 11 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Phosphotransferases
Humulus
Protein Folding
Dissection
109 Citations (Scopus)

Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo

Matthews, D. J., Yakes, F. M., Chen, J., Tadano, M., Bornheim, L., Clary, D. O., Tai, A., Wagner, J. M., Miller, N., Kim, Y. D., Robertson, S., Murray, L. & Karnitz, L. M., Jan 1 2007, In : Cell Cycle. 6, 1, p. 104-110 7 p.

Research output: Contribution to journalArticle

gemcitabine
S Phase Cell Cycle Checkpoints
Tumors
Pharmacology
Phosphorylation
294 Citations (Scopus)

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1

Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K. I. & Karnitz, L. M., Jun 15 2007, In : Genes and Development. 21, 12, p. 1472-1477 6 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia Mutated Proteins
Proliferating Cell Nuclear Antigen
DNA Replication
Histones
Chromatin
2006
69 Citations (Scopus)

Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones

Arlander, S. J. H., Felts, S. J., Wagner, J. M., Stensgard, B., Toft, D. O. & Karnitz, L. M., Feb 3 2006, In : Journal of Biological Chemistry. 281, 5, p. 2989-2998 10 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Phosphotransferases
Checkpoint Kinase 1
Casein Kinase II
Humulus
2005
94 Citations (Scopus)

Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival

Karnitz, L. M., Flatten, K. S., Wagner, J. M., Loegering, D., McDonald, J. S., Arlander, S. J. H., Vroman, B. T., Thomas, M. B., Baek, Y. U., Hopkins, K. M., Lieberman, H. B., Chen, J., Cliby, W. A. & Kaufmann, S. H., Dec 2005, In : Molecular Pharmacology. 68, 6, p. 1636-1644 9 p.

Research output: Contribution to journalArticle

gemcitabine
Ataxia Telangiectasia
Cell Survival
Cytarabine
Phosphotransferases
93 Citations (Scopus)

Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine

Mesa, R. A., Loegering, D., Powell, H. L., Flatten, K., Arlander, S. J. H., Dai, N. T., Heldebrant, M. P., Vroman, B. T., Smith, B. D., Karp, J. E., Ten Eyck, C. J., Erlichman, C., Kaufmann, S. H. & Karnitz, L. M., Jul 1 2005, In : Blood. 106, 1, p. 318-327 10 p.

Research output: Contribution to journalArticle

tanespimycin
HSP90 Heat-Shock Proteins
Cytarabine
Acute Myeloid Leukemia
Phosphotransferases
86 Citations (Scopus)

The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons

Flatten, K., Dai, N. T., Vroman, B. T., Loegering, D., Erlichman, C., Karnitz, L. M. & Kaufmann, S. H., Apr 8 2005, In : Journal of Biological Chemistry. 280, 14, p. 14349-14355 7 p.

Research output: Contribution to journalArticle

irinotecan
Type I DNA Topoisomerase
Poisons
Ataxia Telangiectasia
Phosphotransferases
2004
213 Citations (Scopus)

Dial 9-1-1 for DNA damage: The Rad9-Hus1-Rad1 (9-1-1) clamp complex

Parrilla-Castellar, E. R., Arlander, S. J. H. & Karnitz, L. M., Aug 2004, In : DNA Repair. 3, 8-9, p. 1009-1014 6 p.

Research output: Contribution to journalArticle

Clamping devices
DNA Repair
DNA Damage
Proliferating Cell Nuclear Antigen
DNA

Purification and identification of protein complexes that control the cell cycle.

Burtelow, M. A., Podust, V. N. & Karnitz, L. M., 2004, In : Methods in molecular biology (Clifton, N.J.). 241, p. 247-253 7 p.

Research output: Contribution to journalArticle

Cell Cycle Proteins
Baculoviridae
Cell Cycle Checkpoints
Glutathione Transferase
Biochemistry
32 Citations (Scopus)

Rad9 Protects Cells from Topoisomerase Poison-induced Cell Death

Loegering, D., Arlander, S. J. H., McDonald, J. S., Vroman, B. T., Roos-Mattjus, P., Hopkins, K. M., Lieberman, H. B., Karnitz, L. M. & Kaufmann, S. H., Apr 30 2004, In : Journal of Biological Chemistry. 279, 18, p. 18641-18647 7 p.

Research output: Contribution to journalArticle

Poisons
Cell death
Embryonic Stem Cells
Stem cells
Cytarabine
35 Citations (Scopus)

S-peptide epitope tagging for protein purification, expression monitoring, and localization in mammalian cells

McDonald, J. S., Lee, S. H., Meng, X. W., Vroman, B. T., Kaufmann, S. H. & Karnitz, L. M., Nov 2004, In : BioTechniques. 37, 5, p. 835-839 5 p.

Research output: Contribution to journalArticle

Purification
Epitopes
Cells
Peptides
Monitoring
2003
35 Citations (Scopus)

Cloning and characterization of hCTF18, hCTF8, and hDCC1: Human homologs of an Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment

Merkle, C. J., Karnitz, L. M., Henry-Sánchez, J. T. & Chen, J., Aug 8 2003, In : Journal of Biological Chemistry. 278, 32, p. 30051-30056 6 p.

Research output: Contribution to journalArticle

Replication Protein C
Chromatids
Cloning
Yeast
Saccharomyces cerevisiae
57 Citations (Scopus)

Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin

Parrilla-Castellar, E. R. & Karnitz, L. M., Nov 14 2003, In : Journal of Biological Chemistry. 278, 46, p. 45507-45511 5 p.

Research output: Contribution to journalArticle

Mutagens
DNA-Directed DNA Polymerase
DNA Damage
Chromatin
DNA
142 Citations (Scopus)

Hsp90 Inhibition Depletes Chk1 and Sensitizes Tumor Cells to Replication Stress

Arlander, S. J. H., Eapen, A. K., Vroman, B. T., McDonald, R., Toft, D. O. & Karnitz, L. M., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52572-52577 6 p.

Research output: Contribution to journalArticle

tanespimycin
Tumors
Cells
gemcitabine
S Phase
12 Citations (Scopus)

Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene

Dufault, V. M., Oestreich, A. J., Vroman, B. T. & Karnitz, L. M., Dec 2003, In : Genomics. 82, 6, p. 644-651 8 p.

Research output: Contribution to journalArticle

Mutagens
Proliferating Cell Nuclear Antigen
Immunoprecipitation
Northern Blotting
Genes
97 Citations (Scopus)

Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint Signaling

Roos-Mattjus, P., Hopkins, K. M., Oestreich, A. J., Vroman, B. T., Johnson, K. L., Naylor, S., Lieberman, H. B. & Karnitz, L. M., Jul 4 2003, In : Journal of Biological Chemistry. 278, 27, p. 24428-24437 10 p.

Research output: Contribution to journalArticle

Phosphorylation
Mutagens
Ionizing radiation
Ionizing Radiation
Hydroxyurea
2002
72 Citations (Scopus)

Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event

Roos-Mattjus, P., Vroman, B. T., Burtelow, M. A., Rauen, M., Eapen, A. K. & Karnitz, L. M., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 43809-43812 4 p.

Research output: Contribution to journalArticle

Mutagens
Chromatin
Association reactions
Replication Protein C
DNA
2001
107 Citations (Scopus)

Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex

Burtelow, M. A., Roos-Mattjus, P. M. K., Rauen, M., Babendure, J. R. & Karnitz, L. M., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 25903-25909 7 p.

Research output: Contribution to journalArticle

DNA Damage
DNA
Proteins
Cells
Cell Cycle Checkpoints
2000
584 Citations (Scopus)

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

Sekulic, A. D., Hudson, C. C., Homme, J. L., Yin, P., Otterness, D. M., Karnitz, L. M. & Abraham, R. T., Jul 1 2000, In : Cancer Research. 60, 13, p. 3504-3513 10 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Sirolimus
Mitogens
Phosphorylation
Protein Kinases
96 Citations (Scopus)

Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage

Burtelow, M. A., Kaufmann, S. H. & Karnitz, L. M., Aug 25 2000, In : Journal of Biological Chemistry. 275, 34, p. 26343-26348 6 p.

Research output: Contribution to journalArticle

DNA Damage
DNA
Genes
Mammals
Hydroxyurea
167 Citations (Scopus)

The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3- kinase-dependent survival signaling cascade

Rust, C., Karnitz, L. M., Paya, C. V., Moscat, J., Simari, R. D. & Gores, G. J., Jun 30 2000, In : Journal of Biological Chemistry. 275, 26, p. 20210-20216 7 p.

Research output: Contribution to journalArticle

Taurochenodeoxycholic Acid
Phosphatidylinositol 3-Kinase
Bile Acids and Salts
Glycochenodeoxycholic Acid
Chenodeoxycholic Acid
81 Citations (Scopus)

The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9

Rauen, M., Burtelow, M. A., Dufault, V. M. & Karnitz, L. M., Sep 22 2000, In : Journal of Biological Chemistry. 275, 38, p. 29767-29771 5 p.

Research output: Contribution to journalArticle

Clamping devices
Proliferating Cell Nuclear Antigen
Replication Protein C
DNA Damage
Loaders
301 Citations (Scopus)

The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

Busby, E. C., Leistritz, D. F., Abraham, R. T., Karnitz, L. M. & Sarkaria, J. N., Apr 15 2000, In : Cancer Research. 60, 8, p. 2108-2112 5 p.

Research output: Contribution to journalArticle

Radiation-Sensitizing Agents
DNA Damage
Phosphotransferases
Antineoplastic Agents
cdc25 Phosphatases