Larry M Karnitz, PhD

  • 6665 Citations
  • 41 Scopus h-Index
1984 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 6665 Citations
  • 41 Scopus h-Index
  • 72 Article
  • 4 Review article
  • 1 Editorial
Filter
Article
2019

BRCA1 deficiency upregulates NNMT, which reprograms metabolism and sensitizes ovarian cancer cells to mitochondrial metabolic targeting agents

Kanakkanthara, A., Kurmi, K., Ekstrom, T. L., Hou, X., Purfeerst, E. R., Heinzen, E. P., Correia, C., Huntoon, C. J., O'Brien, D., Wahner Hendrickson, A. E., Dowdy, S. C., Li, H., Oberg, A. L., Hitosugi, T., Kaufmann, S. H., Weroha, S. J. & Karnitz, L. M., Dec 1 2019, In : Cancer research. 79, 23, p. 5920-5929 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo

Vincelette, N. D., Ding, H., Huehls, A. M., Flatten, K. S., Kelly, R. L., Kohorst, M. A., Webster, J., Hess, A. D., Pratz, K. W., Karnitz, L. M. & Kaufmann, S. H., Dec 1 2019, In : Scientific reports. 9, 1, 3617.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

Kanakkanthara, A., Huntoon, C. J., Hou, X., Zhang, M., Heinzen, E. P., O’Brien, D. R., Oberg, A. L., John Weroha, S., Kaufmann, S. H. & Karnitz, L. M., Dec 1 2019, In : Nature communications. 10, 1, 4632.

Research output: Contribution to journalArticle

Open Access
2018

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye-Agyeman, F., Gonsalves, W., Lou, Z., Karnitz, L. M., Goetz, M. P. & Hitosugi, T. D., Feb 6 2018, In : Cell Reports. 22, 6, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

Kurmi, K., Hitosugi, S., Yu, J., Boakye-Agyeman, F., Wiese, E. K., Larson, T. R., Dai, Q., Machida, Y., Lou, Z., Wang, L. M., Boughey, J. C., Kaufmann, S. H., Goetz, M. P., Karnitz, L. M. & Hitosugi, T. D., Dec 4 2018, In : Cell Metabolism. 28, 6, p. 833-847.e8

Research output: Contribution to journalArticle

7 Scopus citations
2017

A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia

Gojo, I., Beumer, J. H., Pratz, K. W., McDevitt, M. A., Baer, M. R., Blackford, A. L., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Levis, M. J., Dezern, A. E., Gladstone, D. E., Ji, J. J., Wang, L., Kinders, R. J., Pouquet, M., Ali-Walbi, I., Rudek, M. A., Poh, W. & 5 others, Herman, J. G., Karnitz, L. M., Kaufmann, S. H., Chen, A. & Karp, J. E., Feb 1 2017, In : Clinical Cancer Research. 23, 3, p. 697-706 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

A phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms, and chronic myelomonocytic leukemia

Pratz, K. W., Rudek, M. A., Gojo, I., Litzow, M. R., McDevitt, M. A., Ji, J., Karnitz, L. M., Herman, J. G., Kinders, R. J., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Gladstone, D. E., Levis, M. J., Tsai, H. L., Rosner, G., Chen, A., Kaufmann, S. H. & Karp, J. E., Feb 15 2017, In : Clinical Cancer Research. 23, 4, p. 899-907 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Randomized phase II trial of cytosine arabinoside with and without the CHK1 inhibitor MK-8776 in relapsed and refractory acute myeloid leukemia

Webster, J. A., Tibes, R., Morris, L., Blackford, A. L., Litzow, M., Patnaik, M., Rosner, G. L., Gojo, I., Kinders, R., Wang, L., Doyle, L. A., Huntoon, C. J., Karnitz, L. M., Kaufmann, S. H., Karp, J. E. & Smith, B. D., Oct 1 2017, In : Leukemia Research. 61, p. 108-116 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2016

Genomically incorporated 5-fluorouracil that escapes ung-initiated base excision repair blocks dna replication and activates homologous recombination

Huehls, A. M., Huntoon, C. J., Joshi, P. M., Baehr, C. A., Wagner, J. M., Wang, X., Lee, M. Y. & Karnitz, L. M., Jan 1 2016, In : Molecular pharmacology. 89, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Glycogen synthase kinase 3 (GSK-3)-mediated phosphorylation of uracil N-glycosylase 2 (UNG2) facilitates the repair of floxuridine-induced DNA lesions and promotes cell survival

Baehr, C. A., Huntoon, C. J., Hoang, S. M., Jerde, C. R. & Karnitz, L. M., Dec 23 2016, In : Journal of Biological Chemistry. 291, 52, p. 26875-26885 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Molecular pathways: Targeting ATR in cancer therapy

Karnitz, L. M. & Zou, L., Nov 1 2015, In : Clinical Cancer Research. 21, 21, p. 4780-4785 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation

Jilani, Y., Lu, S., Lei, H., Karnitz, L. M. & Chadli, A., Feb 1 2015, In : Cancer Letters. 357, 1, p. 114-120 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014
91 Scopus citations
2013

ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status

Huntoon, C. J., Flatten, K. S., Wahner Hendrickson, A. E., Huehls, A. M., Sutor, S. L., Kaufmann, S. H. & Karnitz, L. M., Jun 15 2013, In : Cancer research. 73, 12, p. 3683-3691 9 p.

Research output: Contribution to journalArticle

96 Scopus citations
2012

A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma

Wahner Hendrickson, A. E., Oberg, A. L., Glaser, G., Camoriano, J. K., Peethambaram, P. P., Colon-Otero, G., Erlichman, C., Ivy, S. P., Kaufmann, S. H., Karnitz, L. M. & Haluska, P., Feb 1 2012, In : Gynecologic oncology. 124, 2, p. 210-215 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro

Schenk, E. L., Koh, B. D., Flatten, K. S., Peterson, K. L., Parry, D., Hess, A. D., Smith, B. D., Karp, J. E., Karnitz, L. M. & Kaufmann, S. H., Oct 1 2012, In : Clinical Cancer Research. 18, 19, p. 5364-5373 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination

Huehls, A. M., Wagner, J. M., Huntoon, C. J. & Karnitz, L. M., Oct 2012, In : Molecular pharmacology. 82, 4, p. 767-776 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil

Geng, L., Huehls, A. M., Wagner, J. M., Huntoon, C. J. & Karnitz, L. M., Dec 15 2011, In : PloS one. 6, 12, e28862.

Research output: Contribution to journalArticle

28 Scopus citations

Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia

Kaufmann, S. H., Karp, J. E., Litzow, M. R., Mesa, R. A., Hogan, W., Steensma, D. P., Flatten, K. S., Loegering, D. A., Schneider, P. A., Peterson, K. L., Maurer, M. J., Smith, B. D., Greer, J., Chen, Y., Reid, J. M., Ivy, S. P., Ames, M. M., Adjei, A. A., Erlichman, C. & Karnitz, L. M., Nov 1 2011, In : Haematologica. 96, 11, p. 1619-1626 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells

Huehls, A. M., Wagner, J. M., Huntoon, C. J., Geng, L., Erlichman, C., Patel, A. G., Kaufmann, S. H. & Karnitz, L. M., Jul 15 2011, In : Cancer research. 71, 14, p. 4944-4954 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2010

Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway

Huntoon, C. J., Nye, M. D., Geng, L., Peterson, K. L., Flatten, K. S., Haluska, P., Kaufmann, S. H. & Karnitz, L. M., Nov 1 2010, In : Cancer research. 70, 21, p. 8642-8650 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network

Geng, L., Huntoon, C. J. & Karnitz, L. M., Oct 18 2010, In : Journal of Cell Biology. 191, 2, p. 249-257 9 p.

Research output: Contribution to journalArticle

70 Scopus citations
2009
81 Scopus citations
2008

Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I

Hackbarth, J. S., Galvez-Peralta, M., Dai, N. T., Loegering, D. A., Peterson, K. L., Meng, X. W., Karnitz, L. M. & Kaufmann, S. H., Jun 13 2008, In : Journal of Biological Chemistry. 283, 24, p. 16711-16722 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Overcoming S-phase checkpoint-mediated resistance: Sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines

Gálvez-Peralta, M., Dai, N. T., Loegering, D. A., Flatten, K. S., Safgren, S. L., Wagner, J. M., Ames, M. M., Karnitz, L. M. & Kaufmann, S. H., Sep 2008, In : Molecular pharmacology. 74, 3, p. 724-735 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Sonic Hedgehog signaling impairs ionizing radiation - Induced checkpoint activation and induces genomic instability

Leonard, J. M., Ye, H., Wetmore, C. & Karnitz, L. M., Nov 3 2008, In : Journal of Cell Biology. 183, 3, p. 385-391 7 p.

Research output: Contribution to journalArticle

49 Scopus citations
2007

An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function

Scroggins, B. T., Robzyk, K., Wang, D., Marcu, M. G., Tsutsumi, S., Beebe, K., Cotter, R. J., Felts, S., Toft, D., Karnitz, L., Rosen, N. & Neckers, L., Jan 12 2007, In : Molecular Cell. 25, 1, p. 151-159 9 p.

Research output: Contribution to journalArticle

292 Scopus citations

Functioning of the Hsp90 machine in chaperoning checkpoint kinase 1 (Chk1) and the progesterone receptor (PR)

Felts, S. J., Karnitz, L. M. & Toft, D. O., Dec 1 2007, In : Cell Stress and Chaperones. 12, 4, p. 353-363 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo

Matthews, D. J., Yakes, F. M., Chen, J., Tadano, M., Bornheim, L., Clary, D. O., Tai, A., Wagner, J. M., Miller, N., Kim, Y. D., Robertson, S., Murray, L. & Karnitz, L. M., Jan 1 2007, In : Cell Cycle. 6, 1, p. 104-110 7 p.

Research output: Contribution to journalArticle

Open Access
111 Scopus citations

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1

Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K. I. & Karnitz, L. M., Jun 15 2007, In : Genes and Development. 21, 12, p. 1472-1477 6 p.

Research output: Contribution to journalArticle

308 Scopus citations
2006

Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones

Arlander, S. J. H., Felts, S. J., Wagner, J. M., Stensgard, B., Toft, D. O. & Karnitz, L. M., Feb 3 2006, In : Journal of Biological Chemistry. 281, 5, p. 2989-2998 10 p.

Research output: Contribution to journalArticle

71 Scopus citations
2005

Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival

Karnitz, L. M., Flatten, K. S., Wagner, J. M., Loegering, D., Hackbarth, J. S., Arlander, S. J. H., Vroman, B. T., Thomas, M. B., Baek, Y. U., Hopkins, K. M., Lieberman, H. B., Chen, J., Cliby, W. A. & Kaufmann, S. H., Dec 1 2005, In : Molecular pharmacology. 68, 6, p. 1636-1644 9 p.

Research output: Contribution to journalArticle

100 Scopus citations

Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine

Mesa, R. A., Loegering, D., Powell, H. L., Flatten, K., Arlander, S. J. H., Dai, N. T., Heldebrant, M. P., Vroman, B. T., Smith, B. D., Karp, J. E., Ten Eyck, C. J., Erlichman, C., Kaufmann, S. H. & Karnitz, L. M., Jul 1 2005, In : Blood. 106, 1, p. 318-327 10 p.

Research output: Contribution to journalArticle

95 Scopus citations

The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons

Flatten, K., Dai, N. T., Vroman, B. T., Loegering, D., Erlichman, C., Karnitz, L. M. & Kaufmann, S. H., Apr 8 2005, In : Journal of Biological Chemistry. 280, 14, p. 14349-14355 7 p.

Research output: Contribution to journalArticle

89 Scopus citations
2004

Purification and identification of protein complexes that control the cell cycle.

Burtelow, M. A., Podust, V. N. & Karnitz, L. M., 2004, In : Methods in molecular biology (Clifton, N.J.). 241, p. 247-253 7 p.

Research output: Contribution to journalArticle

Rad9 Protects Cells from Topoisomerase Poison-induced Cell Death

Loegering, D., Arlander, S. J. H., Hackbarth, J., Vroman, B. T., Roos-Mattjus, P., Hopkins, K. M., Lieberman, H. B., Karnitz, L. M. & Kaufmann, S. H., Apr 30 2004, In : Journal of Biological Chemistry. 279, 18, p. 18641-18647 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

S-peptide epitope tagging for protein purification, expression monitoring, and localization in mammalian cells

Hackbarth, J. S., Lee, S. H., Meng, X. W., Vroman, B. T., Kaufmann, S. H. & Karnitz, L. M., Nov 1 2004, In : BioTechniques. 37, 5, p. 835-839 5 p.

Research output: Contribution to journalArticle

38 Scopus citations
2003

Cloning and characterization of hCTF18, hCTF8, and hDCC1: Human homologs of an Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment

Merkle, C. J., Karnitz, L. M., Henry-Sánchez, J. T. & Chen, J., Aug 8 2003, In : Journal of Biological Chemistry. 278, 32, p. 30051-30056 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin

Parrilla-Castellar, E. R. & Karnitz, L. M., Nov 14 2003, In : Journal of Biological Chemistry. 278, 46, p. 45507-45511 5 p.

Research output: Contribution to journalArticle

57 Scopus citations

Hsp90 Inhibition Depletes Chk1 and Sensitizes Tumor Cells to Replication Stress

Arlander, S. J. H., Eapen, A. K., Vroman, B. T., McDonald, R. J., Toft, D. O. & Karnitz, L. M., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52572-52577 6 p.

Research output: Contribution to journalArticle

146 Scopus citations

Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene

Dufault, V. M., Oestreich, A. J., Vroman, B. T. & Karnitz, L. M., Dec 2003, In : Genomics. 82, 6, p. 644-651 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint Signaling

Roos-Mattjus, P., Hopkins, K. M., Oestreich, A. J., Vroman, B. T., Johnson, K. L., Naylor, S., Lieberman, H. B. & Karnitz, L. M., Jul 4 2003, In : Journal of Biological Chemistry. 278, 27, p. 24428-24437 10 p.

Research output: Contribution to journalArticle

97 Scopus citations
2002

Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event

Roos-Mattjus, P., Vroman, B. T., Burtelow, M. A., Rauen, M., Eapen, A. K. & Karnitz, L. M., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 43809-43812 4 p.

Research output: Contribution to journalArticle

72 Scopus citations
2001

Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex

Burtelow, M. A., Roos-Mattjus, P. M. K., Rauen, M., Babendure, J. R. & Karnitz, L. M., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 25903-25909 7 p.

Research output: Contribution to journalArticle

107 Scopus citations
2000

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

Sekulić, A., Hudson, C. C., Homme, J. L., Yin, P., Otterness, D. M., Karnitz, L. M. & Abraham, R. T., Jul 1 2000, In : Cancer research. 60, 13, p. 3504-3513 10 p.

Research output: Contribution to journalArticle

598 Scopus citations

Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage

Burtelow, M. A., Kaufmann, S. H. & Karnitz, L. M., Aug 25 2000, In : Journal of Biological Chemistry. 275, 34, p. 26343-26348 6 p.

Research output: Contribution to journalArticle

96 Scopus citations

The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3- kinase-dependent survival signaling cascade

Rust, C., Karnitz, L. M., Paya, C. V., Moscat, J., Simari, R. D. & Gores, G. J., Jun 30 2000, In : Journal of Biological Chemistry. 275, 26, p. 20210-20216 7 p.

Research output: Contribution to journalArticle

168 Scopus citations

The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9

Rauen, M., Burtelow, M. A., Dufault, V. M. & Karnitz, L. M., Sep 22 2000, In : Journal of Biological Chemistry. 275, 38, p. 29767-29771 5 p.

Research output: Contribution to journalArticle

82 Scopus citations

The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

Busby, E. C., Leistritz, D. F., Abraham, R. T., Karnitz, L. M. & Sarkaria, J. N., Apr 15 2000, In : Cancer research. 60, 8, p. 2108-2112 5 p.

Research output: Contribution to journalArticle

301 Scopus citations
1999

A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf

Sutor, S. L., Vroman, B. T., Armstrong, E. A., Abraham, R. T. & Karnitz, L. M., Mar 12 1999, In : Journal of Biological Chemistry. 274, 11, p. 7002-7010 9 p.

Research output: Contribution to journalArticle

65 Scopus citations