• 12930 Citations
  • 50 Scopus h-Index
1980 …2021
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Research Output 1993 2019

  • 12930 Citations
  • 50 Scopus h-Index
  • 186 Article
  • 4 Review article
  • 1 Comment/debate
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Article
2017
45 Citations (Scopus)

Radiogenomics to characterize regional genetic heterogeneity in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Baxter, L. C., Gaw, N., Ranjbar, S., Plasencia, J., Dueck, A., Peng, S., Smith, K. A., Nakaji, P., Karis, J. P., Quarles, C. C., Wu, T., Loftus, J. C., Jenkins, R. B., Sicotte, H., Kollmeyer, T. M., O'Neill, B. P., Elmquist, W. & 7 others, Hoxworth, J. M., Frakes, D., Sarkaria, J. N., Swanson, K., Tran, N., Li, J. & Mitchell, J. R., 2017, In : Neuro-Oncology. 19, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Glioblastoma
erbB-1 Genes
Neoplasms
Biopsy
2 Citations (Scopus)
Glioblastoma
Methylation
Polymerase Chain Reaction
Gliosarcoma
Biopsy
6 Citations (Scopus)

Restricted delivery of talazoparib across the blood–brain barrier limits the sensitizing effects of PARP inhibition on temozolomide therapy in glioblastoma

Kizilbash, S., Gupta, S. K., Chang, K., Kawashima, R., Parrish, K. E., Carlson, B. L., Bakken, K. K., Mladek, A. C., Schroeder, M. A., Decker, P. A., Kitange, G. J., Shen, Y., Feng, Y., Protter, A. A., Elmquist, W. F. & Sarkaria, J. N., Dec 1 2017, In : Molecular Cancer Therapeutics. 16, 12, p. 2735-2746 12 p.

Research output: Contribution to journalArticle

temozolomide
Poly(ADP-ribose) Polymerases
Glioblastoma
Therapeutics
Heterografts
9 Citations (Scopus)

Spatially graded hydrogels for preclinical testing of glioblastoma anticancer therapeutics

Pedron, S., Polishetty, H., Pritchard, A. M., Mahadik, B. P., Sarkaria, J. N. & Harley, B. A. C., Sep 1 2017, In : MRS Communications. 7, 3, p. 442-449 8 p.

Research output: Contribution to journalArticle

Hydrogels
Tumors
Biomimetics
Testing
Biocompatible Materials
4 Citations (Scopus)

Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Wang, H., Nguyen, A., Kamocka, M. M., Cai, W., Cohen-Gadol, A. A., Halum, S. L., Sarkaria, J. N., Pollok, K. E. & Safa, A. R., Dec 1 2017, In : Journal of Neurosurgery. 127, 6, p. 1219-1230 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
Stem Cells
Growth
Neoplasms
2016
9 Citations (Scopus)

Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma

Kurokawa, C., Geekiyanage, H., Allen, C., Iankov, I., Schroeder, M., Carlson, B., Bakken, K., Sarkaria, J. N., Ecsedy, J. A., D'Assoro, A., Friday, B. & Galanis, E., Nov 5 2016, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Aurora Kinase A
Heterografts
Neoplasms
Caudate Nucleus
29 Citations (Scopus)

Delineation of MGMT Hypermethylation as a Biomarker for Veliparib-Mediated Temozolomide-Sensitizing Therapy of Glioblastoma

Gupta, S. K., Kizilbash, S., Carlson, B. L., Mladek, A. C., Boakye-Agyeman, F., Bakken, K. K., Pokorny, J. L., Schroeder, M. A., Decker, P. A., Cen, L., Eckel-Passow, J. E., Sarkar, G., Ballman, K. V., Reid, J. M., Jenkins, R. B., Verhaak, R. G., Sulman, E. P., Kitange, G. J. & Sarkaria, J. N., May 1 2016, In : Journal of the National Cancer Institute. 108, 5, djv369.

Research output: Contribution to journalArticle

temozolomide
Methyltransferases
Glioblastoma
Biomarkers
Heterografts
8 Citations (Scopus)

Factors influencing the central nervous system distribution of a novel phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor GSK2126458: Implications for overcoming resistance with combination therapy for melanoma brain metastasess

Vaidhyanathan, S., Wilken-Resman, B., Ma, D. J., Parrish, K. E., Mittapalli, R. K., Carlson, B. L., Sarkaria, J. N. & Elmquist, W. F., Feb 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 356, 2, p. 251-259 9 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Sirolimus
Melanoma
Central Nervous System
Brain
23 Citations (Scopus)

Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth

Hashizume, R., Zhang, A., Mueller, S., Prados, M. D., Lulla, R. R., Goldman, S., Saratsis, A. M., Mazar, A. P., Stegh, A. H., Cheng, S. Y., Horbinski, C., Haas-Kogan, D. A., Sarkaria, J. N., Waldman, T. & James, C. D., Nov 1 2016, In : Neuro-Oncology. 18, 11, p. 1519-1528 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
DNA Repair
DNA Damage
Radiation
17 Citations (Scopus)

InsR/IGF1R pathway mediates resistance to EGFR inhibitors in glioblastoma

Ma, Y., Tang, N., Thompson, R. C., Mobley, B. C., Clark, S. W., Sarkaria, J. N. & Wang, J., Apr 1 2016, In : Clinical Cancer Research. 22, 7, p. 1767-1776 10 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Insulin Receptor
Glioblastoma
Heterografts
Receptor Protein-Tyrosine Kinases
21 Citations (Scopus)

Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation

Gong, Y., Ma, Y., Sinyuk, M., Loganathan, S., Thompson, R. C., Sarkaria, J. N., Chen, W., Lathia, J. D., Mobley, B. C., Clark, S. W. & Wang, J., Jan 1 2016, In : Neuro-Oncology. 18, 1, p. 48-57 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Insulin Receptor
Insulin
Survival
Somatomedin Receptors
13 Citations (Scopus)

Network Modeling Identifies Patient-specific Pathways in Glioblastoma

Tuncbag, N., Milani, P., Pokorny, J. L., Johnson, H., Sio, T. T., Dalin, S., Iyekegbe, D. O., White, F. M., Sarkaria, J. N. & Fraenkel, E., Jun 29 2016, In : Scientific Reports. 6, 28668.

Research output: Contribution to journalArticle

Glioblastoma
Neoplasms
Proteins
Patient-Specific Modeling
Brain Neoplasms
12 Citations (Scopus)

Quantitative phosphoproteomics reveals wee1 kinase as a therapeutic target in a model of proneural glioblastoma

Lescarbeau, R. S., Lei, L., Bakken, K. K., Sims, P. A., Sarkaria, J. N., Canoll, P. & White, F. M., Jun 1 2016, In : Molecular Cancer Therapeutics. 15, 6, p. 1332-1343 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Phosphotransferases
Phosphorylation
Heterografts
DNA Damage
9 Citations (Scopus)

SGEF is regulated via TWEAK/Fn14/NF-κB signaling and promotes survival by modulation of the DNA repair response to temozolomide

Fortin Ensign, S. P., Roos, A., Mathews, I. T., Dhruv, H. D., Tuncali, S., Sarkaria, J. N., Symons, M. H., Loftus, J. C., Berens, M. E. & Tran, N., Mar 1 2016, In : Molecular Cancer Research. 14, 3, p. 302-312 11 p.

Research output: Contribution to journalArticle

temozolomide
DNA Repair
Glioblastoma
Glioma
Therapeutics
73 Citations (Scopus)

Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma

Oberoi, R. K., Parrish, K. E., Sio, T. T., Mittapalli, R. K., Elmquist, W. F. & Sarkaria, J. N., Jan 1 2016, In : Neuro-Oncology. 18, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Blood-Brain Barrier
Pharmaceutical Preparations
Brain Neoplasms
Neoplasms
2015
47 Citations (Scopus)

A phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057K

Ma, D. J., Galanis, E., Anderson, S. K., Schiff, D., Kaufmann, T. J., Peller, P. J., Giannini, C., Brown, P. D., Uhm, J. H., McGraw, S., Jaeckle, K. A., Flynn, P. J., Ligon, K. L., Buckner, J. C. & Sarkaria, J. N., Sep 1 2015, In : Neuro-Oncology. 17, 9, p. 1261-1269 9 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Radiotherapy
Sirolimus
Phosphatidylinositol 3-Kinase
19 Citations (Scopus)

Brain Malignancy Steering Committee clinical trials planning workshop: Report from the Targeted Therapies Working Group

Alexander, B. M., Galanis, E., Yung, W. K. A., Ballman, K. V., Boyett, J. M., Cloughesy, T. F., Degroot, J. F., Huse, J. T., Mann, B., Mason, W., Mellinghoff, I. K., Mikkelsen, T., Mischel, P. S., O'Neill, B. P., Prados, M. D., Sarkaria, J. N., Tawab-Amiri, A., Trippa, L., Ye, X., Ligon, K. L. & 2 others, Berry, D. A. & Wen, P. Y., Feb 1 2015, In : Neuro-Oncology. 17, 2, p. 180-188 9 p.

Research output: Contribution to journalArticle

Group Psychotherapy
Clinical Trials
Education
Hope
Brain
15 Citations (Scopus)

CNS Anticancer Drug Discovery and Development Conference White Paper

Levin, V. A., Tonge, P. J., Gallo, J. M., Birtwistle, M. R., Dar, A. C., Iavarone, A., Paddison, P. J., Heffron, T. P., Elmquist, W. F., Lachowicz, J. E., Johnson, T. W., White, F. M., Sul, J., Smith, Q. R., Shen, W., Sarkaria, J. N., Samala, R., Wen, P. Y., Berry, D. A. & Petter, R. C., May 24 2015, In : Neuro-Oncology. 17, p. vi1-vi26

Research output: Contribution to journalArticle

Drug Discovery
Pharmaceutical Preparations
Critical Pathways
Drug Industry
Brain Neoplasms
17 Citations (Scopus)

Convertible MRI contrast: Sensing the delivery and release of anti-glioma nano-drugs

Zhang, L., Zhang, Z., Mason, R. P., Sarkaria, J. N. & Zhao, D., May 12 2015, In : Scientific Reports. 5, 09874.

Research output: Contribution to journalArticle

temozolomide
Manganese
Glioma
Glioblastoma
Pharmaceutical Preparations
8 Citations (Scopus)

Critical functions of RhoB in support of glioblastoma tumorigenesis

Ma, Y., Gong, Y., Cheng, Z., Loganathan, S., Kao, C., Sarkaria, J. N., Abel, T. W. & Wang, J., 2015, In : Neuro-Oncology. 17, 4, p. 516-525 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Carcinogenesis
Neoplasms
Heterografts
rhoB GTP-Binding Protein
5 Citations (Scopus)

Dasatinib in recurrent glioblastoma: Failure as a teacher

Schiff, D. & Sarkaria, J. N., Jul 1 2015, In : Neuro-Oncology. 17, 7, p. 910-911 2 p.

Research output: Contribution to journalArticle

Glioblastoma
Brain Neoplasms
Antineoplastic Agents
Dasatinib
19 Citations (Scopus)

Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma

Becker, C. M., Oberoi, R. K., McFarren, S. J., Muldoon, D. M., Pafundi, D. H., Pokorny, J. L., Brinkmann, D. H., Ohlfest, J. R., Sarkaria, J. N., Largaespada, D. A. & Elmquist, W. F., Sep 1 2015, In : Neuro-Oncology. 17, 9, p. 1210-1219 10 p.

Research output: Contribution to journalArticle

Penetrance
Glioblastoma
Phosphatidylinositol 3-Kinases
P-Glycoprotein
Blood-Brain Barrier
13 Citations (Scopus)

Effective treatment of established GL261 murine gliomas through picornavirus vaccination-enhanced tumor antigen-specific CD8+ T cell responses

Renner, D. N., Jin, F., Litterman, A. J., Balgeman, A. J., Hanson, L. M., Gamez, J. D., Chae, M., Carlson, B. L., Sarkaria, J. N., Parney, I. F., Ohlfest, J. R., Pirko, I., Pavelko, K. D. & Johnson, A. J., May 1 2015, In : PLoS One. 10, 5, e0125565.

Research output: Contribution to journalArticle

Picornaviridae
T-cells
Neoplasm Antigens
Glioma
Tumors
27 Citations (Scopus)

Efficacy of PARP inhibitor rucaparib in orthotopic glioblastoma xenografts is limited by ineffective drug penetration into the central nervous system

Parrish, K. E., Cen, L., Murray, J., Calligaris, D., Kizilbash, S., Mittapalli, R. K., Carlson, B. L., Schroeder, M. A., Sludden, J., Boddy, A. V., Agar, N. Y. R., Curtin, N. J., Elmquist, W. F. & Sarkaria, J. N., Dec 1 2015, In : Molecular Cancer Therapeutics. 14, 12, p. 2735-2743 9 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Heterografts
Central Nervous System
Pharmaceutical Preparations
47 Citations (Scopus)

Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model

Parrish, K. E., Pokorny, J., Mittapalli, R. K., Bakken, K., Sarkaria, J. N. & Elmquist, W. F., Nov 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 355, 2, p. 264-271 8 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 6
Cyclin-Dependent Kinase 4
Blood-Brain Barrier
Brain Neoplasms
Glioblastoma
11 Citations (Scopus)

Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma

Miklossy, G., Youn, U. J., Yue, P., Zhang, M., Chen, C. H., Hilliard, T. S., Paladino, D., Li, Y., Choi, J., Sarkaria, J. N., Kawakami, J. K., Wongwiwatthananukit, S., Chen, Y., Sun, D., Chang, L. C. & Turkson, J., Oct 8 2015, In : Journal of Medicinal Chemistry. 58, 19, p. 7734-7748 15 p.

Research output: Contribution to journalArticle

Karyopherins
Vimentin
Glioma
Heterografts
Thioredoxin Reductase 1
50 Citations (Scopus)

Improving drug delivery to primary and metastatic brain tumors: strategies to overcome the blood-brain barrier

Parrish, K. E., Sarkaria, J. N. & Elmquist, W. F., Apr 1 2015, In : Clinical Pharmacology and Therapeutics. 97, 4, p. 336-346 11 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Brain Neoplasms
Pharmaceutical Preparations
Central Nervous System Neoplasms
Tight Junctions
42 Citations (Scopus)

Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme

Tivnan, A., Zakaria, Z., O'Leary, C., Kögel, D., Pokorny, J. L., Sarkaria, J. N. & Prehn, J. H. M., 2015, In : Frontiers in Neuroscience. 9, MAY, 218.

Research output: Contribution to journalArticle

P-Glycoprotein
Glioblastoma
Drug Therapy
temozolomide
Pharmaceutical Preparations
26 Citations (Scopus)

MARQUIS: A multiplex method for absolute quantification of peptides and posttranslational modifications

Curran, T. G., Zhang, Y., Ma, D. J., Sarkaria, J. N. & White, F. M., 2015, In : Nature Communications. 6, 5924.

Research output: Contribution to journalArticle

phosphorylation
Phosphorylation
Post Translational Protein Processing
peptides
Peptides
35 Citations (Scopus)

Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Gaw, N., Dueck, A., Smith, K. A., Nakaji, P., Plasencia, J., Ranjbar, S., Price, S. J., Tran, N., Loftus, J. C., Jenkins, R. B., O'Neill, B. P., Elmquist, W., Baxter, L. C., Gao, F., Frakes, D., Karis, J. P., Zwart, C. & 5 others, Swanson, K., Sarkaria, J. N., Wu, T., Mitchell, J. R. & Li, J., Nov 1 2015, In : PLoS One. 10, 11, e0141506.

Research output: Contribution to journalArticle

Glioblastoma
Magnetic resonance imaging
Tumors
Textures
texture
5 Citations (Scopus)

Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition

Shen, Y., Li, J., Nitta, M., Futalan, D., Steed, T., Treiber, J. M., Taich, Z., Stevens, D., Wykosky, J., Chen, H. Z., Carter, B. S., Becher, O. J., Kennedy, R., Esashi, F., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K., Desai, A. & Chen, C. C., 2015, In : Oncotarget. 6, 14, p. 11751-11767 17 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Clone Cells
Homologous Recombination
Therapeutic Uses
7 Citations (Scopus)

Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α

Feng, H., Li, Y., Yin, Y., Zhang, W., Hou, Y., Zhang, L., Li, Z., Xie, B., Gao, W. Q., Sarkaria, J. N., Raizer, J. J., James, C. D., Parsa, A. T., Hu, B. & Cheng, S. Y., 2015, In : Neuro-Oncology. 17, 6, p. 832-842 11 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor Receptors
Cyclic AMP-Dependent Protein Kinases
Glioma
Serine
Phosphorylation
11 Citations (Scopus)
Radiation Oncology
Glioma
Lomustine
Procarbazine
Radiotherapy
19 Citations (Scopus)

Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

Kitange, G. J., Mladek, A. C., Schroeder, M. A., Pokorny, J. C., Carlson, B. L., Zhang, Y., Nair, A. A., Lee, J. H., Yan, H. D., Decker, P. A., Zhang, Z. & Sarkaria, J. N., Mar 4 2015, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

temozolomide
Retinoblastoma-Binding Protein 4
Glioblastoma
DNA Repair
Repair
17 Citations (Scopus)

Src family kinases differentially influence glioma growth and motility

Lewis-Tuffin, L. J., Feathers, R., Hari, P., Durand, N., Li, Z., Rodriguez, F. J., Bakken, K., Carlson, B., Schroeder, M., Sarkaria, J. N. & Anastasiadis, P. Z., Nov 1 2015, In : Molecular Oncology. 9, 9, p. 1783-1798 16 p.

Research output: Contribution to journalArticle

src-Family Kinases
Glioma
Growth
Heterografts
Neoplasms
84 Citations (Scopus)

The bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation

Pastori, C., Kapranov, P., Penas, C., Peschansky, V., Volmar, C. H., Sarkaria, J. N., Bregy, A., Komotar, R., Laurent, G. S., Ayad, N. G., Wahlestedt, C. & Roberts, T. C., Jul 7 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8326-8331 6 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Antisense RNA
Glioblastoma
Proteins
Epigenomics
43 Citations (Scopus)

The efficacy of the wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma

Pokorny, J. L., Calligaris, D., Gupta, S. K., Iyekegbe, D. O., Mueller, D., Bakken, K. K., Carlson, B. L., Schroeder, M. A., Evans, D. L., Lou, Z., Decker, P. A., Eckel-Passow, J. E., Pucci, V., Ma, B., Shumway, S. D., Elmquist, W. F., Agar, N. Y. R. & Sarkaria, J. N., Apr 15 2015, In : Clinical Cancer Research. 21, 8, p. 1916-1924 9 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Blood-Brain Barrier
Heterografts
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
3 Citations (Scopus)

Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody

Zhu, S., Kisiel, W., Lu, Y. J., Petersen, L. C., Ndungu, J. M., Moore, T. W., Parker, E. T., Sun, A., Sarkaria, J. N., Snyder, J. P., Liotta, D. C., Brat, D. J., El-Rayes, B. F. & Shoji, M., Apr 1 2015, In : Journal of Drug Targeting. 23, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

Factor VIIa
Thromboplastin
Antibodies
Neoplasms
Heterografts
2014
42 Citations (Scopus)

A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas

Kushwaha, D., Ramakrishnan, V., Ng, K., Steed, T., Nguyen, T., Futalan, D., Akers, J. C., Sarkaria, J. N., Jiang, T., Chowdhury, D., Carter, B. S. & Chen, C. C., 2014, In : Oncotarget. 5, 12, p. 4026-4039 14 p.

Research output: Contribution to journalArticle

Glioblastoma
MicroRNAs
Genome
temozolomide
Transfection
12 Citations (Scopus)

A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death

Shing, J. C., Choi, J. W., Chapman, R., Schroeder, M. A., Sarkaria, J. N., Fauq, A. & Bram, R. J., 2014, In : Cancer Biology and Therapy. 15, 7, p. 895-905 11 p.

Research output: Contribution to journalArticle

Phenylthiourea
Microtubules
Polymerization
Prometaphase
Cell Death
66 Citations (Scopus)

BET bromodomain proteins are required for glioblastoma cell proliferation

Pastori, C., Daniel, M., Penas, C., Volmar, C. H., Johnstone, A. L., Brothers, S. P., Graham, R. M., Allen, B., Sarkaria, J. N., Komotar, R. J., Wahlestedt, C. & Ayad, N. G., Feb 19 2014, In : Epigenetics. 9, 4, p. 611-620 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Proliferation
temozolomide
Cell Cycle
Protein Domains
16 Citations (Scopus)

Cyclophilin B supports MYC and mutant p53-dependent survival of glioblastoma multiforme cells

Choi, J. W., Schroeder, M. A., Sarkaria, J. N. & Bram, R. J., Jan 15 2014, In : Cancer Research. 74, 2, p. 484-496 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival
Endoplasmic Reticulum
Cell Survival
Peptidylprolyl Isomerase
3 Citations (Scopus)

Design and characterization of an economical 192Ir hemi-brain small animal irradiator

Grams, M. P., Wilson, Z. C., Sio, T. T., Beltran, C. J., Tryggestad, E. J., Gupta, S. K., Blackwell, C. R., McCollough, K. P., Sarkaria, J. N. & Furutani, K. M., Oct 1 2014, In : International Journal of Radiation Biology. 90, 10, p. 936-942 7 p.

Research output: Contribution to journalArticle

Tungsten
Equipment and Supplies
Particle Accelerators
Brachytherapy
Brain
26 Citations (Scopus)

Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts

Gupta, S. K., Mladek, A. C., Carlson, B. L., Boakye-Agyeman, F., Bakken, K. K., Kizilbash, S., Schroeder, M. A., Reid, J. M. & Sarkaria, J. N., Jul 15 2014, In : Clinical Cancer Research. 20, 14, p. 3730-3741 12 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Heterografts
DNA Damage
Poly(ADP-ribose) Polymerase Inhibitors
41 Citations (Scopus)

EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180

Feng, H., Hu, B., Vuori, K., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., May 8 2014, In : Oncogene. 33, 19, p. 2504-2512 9 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Glioma
Serine
Phosphorylation
Growth
47 Citations (Scopus)

Factors influencing the CNS distribution of a novel MEK-1/2 inhibitor: Implications for combination therapy for melanoma brain metastases

Vaidhyanathan, S., Mittapalli, R. K., Sarkaria, J. N. & Elmquist, W. F., 2014, In : Drug Metabolism and Disposition. 42, 8, p. 1292-1300 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Melanoma
Neoplasm Metastasis
Brain
P-Glycoprotein
8 Citations (Scopus)

NT113, A pan-ERBB inhibitor with high brain penetrance, inhibits the growth of glioblastoma xenografts with EGFR amplification

Yoshida, Y., Ozawa, T., Yao, T. W., Shen, W., Brown, D., Parsa, A. T., Raizer, J. J., Cheng, S. Y., Stegh, A. H., Mazar, A. P., Giles, F. J., Sarkaria, J. N., Butowski, N., Nicolaides, T. & James, C. D., Dec 1 2014, In : Molecular Cancer Therapeutics. 13, 12, p. 2919-2929 11 p.

Research output: Contribution to journalArticle

Penetrance
Glioblastoma
Heterografts
Brain
Growth
33 Citations (Scopus)
temozolomide
Cytotoxins
Methyltransferases
Glioblastoma
Apoptosis
12 Citations (Scopus)
methotrexate
cisplatin
Methotrexate
Cisplatin
Brain
74 Citations (Scopus)

Tumorgrafts as in vivo surrogates for women with ovarian cancer

Weroha, S. J., Becker, M. A., Enderica-Gonzalez, S., Harrington, S. C., Oberg, A. L., Maurer, M. J., Perkins, S. E., AlHilli, M., Butler, K. A., McKinstry, S., Fink, S., Jenkins, R. B., Hou, X., Kalli, K. R., Goodman, K. M., Sarkaria, J. N., Karlan, B. Y., Kumar, A., Kaufmann, S. H., Hartmann, L. C. & 1 others, Haluska, P., 2014, In : Clinical Cancer Research. 20, 5, p. 1288-1297 10 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Neoplasms
SCID Mice
Fallopian Tubes
Platinum