Jann N Sarkaria, MD

Professor

  • 11569 Citations
  • 48 h-Index
1980 …2021
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  • 3 Similar Profiles
Glioblastoma Medicine & Life Sciences
temozolomide Medicine & Life Sciences
Heterografts Medicine & Life Sciences
Glioma Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Brain Neoplasms Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Radiotherapy Medicine & Life Sciences

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Projects 1980 2021

The Mayo GBM Xenograft National Resource

Sarkaria, J. N.

National Institutes of Health

9/30/165/31/20

Project: Research projectResource-Related Research Projects

Glioblastoma
Heterografts
Neoplasms
Organized Financing
Atlases

MIT/Mayo Physical Sciences Center for Drug Distribution and Efficacy in Brain Tumors

Swanson, K. & Sarkaria, J. N.

National Institutes of Health

8/29/167/31/21

Project: Research projectSpecialized Center--Cooperative Agreements

Natural Science Disciplines
Brain Neoplasms
Neoplasms
Pharmaceutical Preparations
Therapeutics

P53 INDUCTION AS A PREDICTOR OF RADIATION COMPLICATIONS

Sarkaria, J. N.

National Institutes of Health

2/1/97 → …

Project: Research projectPostdoctoral Individual National Research Service Award

Double-Stranded DNA Breaks
Radiation
Skin
Fibroblasts
Radiation Tolerance

CANCER CENTER SUPPORT GRANT (COMPREHENSIVE)

David, C. S., Jenkins, R. B., Cunningham, J. M., Wettstein, P. J., Buckner, J. C., Lingle, W. L., Kocher, J., Highsmith, W. E. J., Beebe, T. J., Vile, R. G., Okuno, S. H., Sarkaria, J. N., Alberts, S. R., Salisbury, J. L., Van Deursen, J., Diasio, R. B., Sargent, D. J., Thibodeau, S. N., Ingle, J. N., Reid, J. M., Colon-Otero, G., Galanis, E., Weinshilboum, R. M., Jenkins, R. B., Banks, P., Flotte, T., Kwon, E. D., Federspiel, M. J., Pitot, H. C., Dewald, G., Held, K., Liebson, P., Banks, P., Prendergast, F., Weiland, L., Wiebeu, E., Moertel, C., Clapham, D., Burnham, N., O'Connell, M., Spelsburg, T., Maihle, N., Katzmann, J., Wieand, H., Kovach, J., Wold, L., Grendahl, D., McCormick, D., Leibson, P., O'Fallon, J., Ames, M., Kline, B., Prendergast, F., Adjei, A., Chute, C., McKean, D., Highsmith, E., Raghavakaimal, S., Pitot, H., Greipp, P., Wieben, E., Roche, P., Leibson, P., Lawson, M., Grendahl, D., McCormick, D., Ames, M., Wieben, E. D., Flotte, T. J. & Adjei, A.

National Institutes of Health

3/1/802/28/19

Project: Research projectCenter Core Grants

Neoplasms
Research
Research Personnel
Cytogenetics
Biostatistics

Research Output 1993 2018

  • 11569 Citations
  • 48 h-Index
  • 171 Article
  • 3 Review article

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

Chen, X., Zhang, M., Gan, H., Wang, H., Lee, J. H., Fang, D., Kitange, G. J., He, L., Hu, Z., Parney, I. F., Meyer, F. B., Giannini, C., Sarkaria, J. N. & Zhang, Z., Dec 1 2018, In : Nature Communications. 9, 1, 2949.

Research output: Contribution to journalArticle

temozolomide
Methyltransferases
Glioblastoma
deoxyribonucleic acid
DNA

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

Jun, H. J., Appleman, V. A., Wu, H. J., Rose, C. M., Pineda, J. J., Yeo, A. T., Delcuze, B., Lee, C., Gyuris, A., Zhu, H., Woolfenden, S., Bronisz, A., Nakano, I., Chiocca, E. A., Bronson, R. T., Ligon, K. L., Sarkaria, J. N., Gygi, S. P., Michor, F., Mitchison, T. J. & 1 othersCharest, A., Dec 1 2018, In : Nature Communications. 9, 1, 3116.

Research output: Contribution to journalArticle

Vinblastine
Glioblastoma
mice
sensitivity
Tubulin

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular cancer therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Radiotherapy
Exome
Homologous Recombination
Neoplasms

Barriers to Effective Drug Treatment for Brain Metastases: A Multifactorial Problem in the Delivery of Precision Medicine

Kim, M., Kizilbash, S. H., Laramy, J. K., Gampa, G., Parrish, K. E., Sarkaria, J. N. & Elmquist, W. F., Sep 1 2018, In : Pharmaceutical Research. 35, 9, 177.

Research output: Contribution to journalReview article

Drug therapy
Precision Medicine
Medicine
Brain
Neoplasm Metastasis
3 Citations

Brain distribution of a novel MEK Inhibitor E6201: Implications in the treatment of melanoma brain metastases

Gampa, G., Kim, M., Cook-Rostie, N., Laramy, J. K., Sarkaria, J. N., Paradiso, L., DePalatis, L. & Elmquist, W. F., May 1 2018, In : Drug Metabolism and Disposition. 46, 5, p. 658-666 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Melanoma
Neoplasm Metastasis
Brain
P-Glycoprotein