• 13070 Citations
  • 50 Scopus h-Index
1980 …2021
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Research Output 1993 2019

  • 13070 Citations
  • 50 Scopus h-Index
  • 186 Article
  • 4 Review article
  • 1 Comment/debate
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Article
2019
1 Citation (Scopus)

Automatic 3D Nonlinear Registration of Mass Spectrometry Imaging and Magnetic Resonance Imaging Data

Abdelmoula, W. M., Regan, M. S., Lopez, B. G. C., Randall, E. C., Lawler, S., Mladek, A. C., Nowicki, M. O., Marin, B. M., Agar, J. N., Swanson, K., Kapur, T., Sarkaria, J. N., Wells, W. & Agar, N. Y. R., May 7 2019, In : Analytical Chemistry. 91, 9, p. 6206-6216 11 p.

Research output: Contribution to journalArticle

Mass spectrometry
Imaging techniques
Magnetic resonance
Magnetic Resonance Imaging
Brain models
2 Citations (Scopus)

Brain Distribution and Active Efflux of Three panRAF Inhibitors: Considerations in the Treatment of Melanoma Brain Metastases

Gampa, G., Kim, M., Mohammad, A. S., Parrish, K. E., Mladek, A. C., Sarkaria, J. N. & Elmquist, W. F., Mar 1 2019, In : The Journal of pharmacology and experimental therapeutics. 368, 3, p. 446-461 16 p.

Research output: Contribution to journalArticle

Melanoma
Neoplasm Metastasis
P-Glycoprotein
Brain
Mitogen-Activated Protein Kinase Kinases
2 Citations (Scopus)

Brain Distribution of a Panel of Epidermal Growth Factor Receptor Inhibitors Using Cassette Dosing in Wild-Type and Abcb1/Abcg2-Deficient Mice

Kim, M., Laramy, J. K., Mohammad, A. S., Talele, S., Fisher, J., Sarkaria, J. N. & Elmquist, W. F., Apr 1 2019, In : Drug metabolism and disposition: the biological fate of chemicals. 47, 4, p. 393-404 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Brain
Blood-Brain Barrier
Non-Small Cell Lung Carcinoma
Brain Neoplasms

Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential

Stalinska, J., Zimolag, E., Pianovich, N. A., Zapata, A., Lassak, A., Rak, M., Dean, M., Ucar-Bilyeu, D., Wyczechowska, D., Culicchia, F., Marrero, L., Del Valle, L., Sarkaria, J. N., Peruzzi, F., Jursic, B. S. & Reiss, K., Jul 1 2019, In : Translational Oncology. 12, 7, p. 895-907 13 p.

Research output: Contribution to journalArticle

Open Access
Fenofibrate
Cell Death
Glioblastoma
Solubility
Neoplasms

ENvironmental dynamics underlying responsive extreme survivors (ENDURES) of glioblastoma: A multidisciplinary team-based, multifactorial analytical approach

Johnston, S. K., Whitmire, P., Massey, S. C., Kumthekar, P., Porter Umphrey, A. B., Raghunand, N., Gonzalez-Cuyar, L. F., Mrugala, M., Hawkins-Daarud, A., Jackson, P. R., Hu, L. S., Sarkaria, J. N., Wang, L., Gatenby, R. A., Egan, K. M., Canoll, P. & Swanson, K., Aug 1 2019, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 42, 8, p. 655-661 7 p.

Research output: Contribution to journalArticle

Glioblastoma
Survivors
Survival
Brain Neoplasms
Neoplasms

Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells

Nagel, Z. D., Beharry, A. A., Mazzucato, P., Kitange, G. J., Sarkaria, J. N., Kool, E. T. & Samson, L. D., Feb 1 2019, In : PloS one. 14, 2, e0208341.

Research output: Contribution to journalArticle

Open Access
methyltransferases
Methyltransferases
Assays
Cells
DNA
1 Citation (Scopus)

Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens

Pedron, S., Wolter, G. L., Chen, J. W. E., Laken, S. E., Sarkaria, J. N. & Harley, B. A. C., Oct 1 2019, In : Biomaterials. 219, 119371.

Research output: Contribution to journalArticle

Hyaluronic acid
Hydrogels
Hyaluronic Acid
Gelatin
Glioblastoma
1 Citation (Scopus)

Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant Gliomas

Unruh, D., Mirkov, S., Wray, B., Drumm, M., Lamano, J., Li, Y. D., Haider, Q. F., Javier, R., McCortney, K., Saratsis, A., Scholtens, D. M., Sarkaria, J. N., David James, C. & Horbinski, C., Jan 15 2019, In : Clinical Cancer Research. 25, 2, p. 747-759 13 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Thromboplastin
Glioma
Methylation
Mutation

Pathogenic Germ Line Variants in a Patient With Severe Toxicity From Breast Radiotherapy

Wilhite, T. J., Youland, R. S., Tian, S., Finley, R. R., Sarkaria, J. N. & Corbin, K. S., Jan 1 2019, In : Clinical breast cancer.

Research output: Contribution to journalArticle

Radiation Tolerance
DNA Replication
Germ Cells
DNA Repair
Breast

Phase I-II trial of imatinib mesylate (Gleevec; STI571) in treatment of recurrent oligodendroglioma and mixed oligoastrocytoma. North central cancer treatment group study N0272 (ALLIANCE/NCCTG)

Jaeckle, K. A., Anderson, S. K., Twohy, E. L., Dixon, J. G., Giannini, C., Jenkins, R. B., Egorin, M. J., Sarkaria, J. N., Brown, P. D., Flynn, P. J., Schwerkoske, J., Buckner, J. C. & Galanis, E., Jul 1 2019, In : Journal of neuro-oncology. 143, 3, p. 573-581 9 p.

Research output: Contribution to journalArticle

Oligodendroglioma
Astrocytoma
Neoplasms
Therapeutics
Anticonvulsants
1 Citation (Scopus)

Quantifying the setup uncertainty of a stereotactic murine micro-image guided radiation therapy system

Walb, M. C., Carlson, B. L., Sarkaria, J. N. & Tryggestad, E. J., Mar 1 2019, In : The British journal of radiology. 92, 1095, 1 p.

Research output: Contribution to journalArticle

Image-Guided Radiotherapy
Cone-Beam Computed Tomography
Uncertainty
Nude Mice
Cranial Irradiation
1 Citation (Scopus)

Temozolomide sensitizes MGMT-deficient tumor cells to ATR inhibitors

Jackson, C. B., Noorbakhsh, S. I., Sundaram, R. K., Kalathil, A. N., Ganesa, S., Jia, L., Breslin, H., Burgenske, D. M., Gilad, O., Sarkaria, J. N. & Bindra, R. S., Sep 1 2019, In : Cancer Research. 79, 17, p. 4331-4338 8 p.

Research output: Contribution to journalArticle

temozolomide
Ataxia Telangiectasia
Methyltransferases
DNA
Neoplasms
2018
11 Citations (Scopus)

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

Chen, X., Zhang, M., Gan, H., Wang, H., Lee, J. H., Fang, D., Kitange, G. J., He, L., Hu, Z., Parney, I. F., Meyer, F. B., Giannini, C., Sarkaria, J. N. & Zhang, Z., Dec 1 2018, In : Nature Communications. 9, 1, 2949.

Research output: Contribution to journalArticle

temozolomide
Methyltransferases
Glioblastoma
deoxyribonucleic acid
DNA
3 Citations (Scopus)

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

Jun, H. J., Appleman, V. A., Wu, H. J., Rose, C. M., Pineda, J. J., Yeo, A. T., Delcuze, B., Lee, C., Gyuris, A., Zhu, H., Woolfenden, S., Bronisz, A., Nakano, I., Chiocca, E. A., Bronson, R. T., Ligon, K. L., Sarkaria, J. N., Gygi, S. P., Michor, F., Mitchison, T. J. & 1 others, Charest, A., Dec 1 2018, In : Nature Communications. 9, 1, 3116.

Research output: Contribution to journalArticle

Vinblastine
Glioblastoma
mice
sensitivity
Tubulin
3 Citations (Scopus)

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular Cancer Therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Radiotherapy
Exome
Homologous Recombination
Neoplasms
7 Citations (Scopus)

Brain distribution of a novel MEK Inhibitor E6201: Implications in the treatment of melanoma brain metastases

Gampa, G., Kim, M., Cook-Rostie, N., Laramy, J. K., Sarkaria, J. N., Paradiso, L., DePalatis, L. & Elmquist, W. F., May 1 2018, In : Drug Metabolism and Disposition. 46, 5, p. 658-666 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Melanoma
Neoplasm Metastasis
Brain
P-Glycoprotein
10 Citations (Scopus)

Constitutive Interferon Pathway Activation in Tumors as an Efficacy Determinant Following Oncolytic Virotherapy

Kurokawa, C., Iankov, I. D., Anderson, S. K., Aderca, I., Leontovich, A. A., Maurer, M. J., Oberg, A. L., Schroeder, M. A., Giannini, C., Greiner, S. M., Becker, M. A., Thompson, E. A., Haluska, P., Jentoft, M. E., Parney, I. F., Weroha, S. J., Jen, J., Sarkaria, J. N. & Galanis, E., Oct 1 2018, In : Journal of the National Cancer Institute. 110, 10, p. 1123-1132 10 p.

Research output: Contribution to journalArticle

Oncolytic Virotherapy
Measles virus
Interferons
Glioblastoma
Heterografts
11 Citations (Scopus)

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Zhou, D., Alver, B. M., Li, S., Hlady, R. A., Thompson, J. J., Schroeder, M. A., Lee, J. H., Qiu, J., Schwartz, P. H., Sarkaria, J. N. & Robertson, K. D., Mar 27 2018, In : Genome Biology. 19, 1, 43.

Research output: Contribution to journalArticle

Glioma
Cues
stem cells
Stem Cells
stem
4 Citations (Scopus)

Drug and disease signature integration identifies synergistic combinations in glioblastoma

Stathias, V., Jermakowicz, A. M., Maloof, M. E., Forlin, M., Walters, W., Suter, R. K., Durante, M. A., Williams, S. L., Harbour, J. W., Volmar, C. H., Lyons, N. J., Wahlestedt, C., Graham, R. M., Ivan, M. E., Komotar, R. J., Sarkaria, J. N., Subramanian, A., Golub, T. R., Schürer, S. C. & Ayad, N. G., Dec 1 2018, In : Nature Communications. 9, 1, 5315.

Research output: Contribution to journalArticle

Glioblastoma
drugs
signatures
Gene expression
Genes
3 Citations (Scopus)

Efficacy of the MDM2 inhibitor SAR405838 in glioblastoma is limited by poor distribution across the blood–brain barrier

Kim, M., Ma, D. J., Calligaris, D., Zhang, S., Feathers, R. W., Vaubel, R. A., Meaux, I., Mladek, A. C., Parrish, K. E., Jin, F., Barriere, C., Debussche, L., Watters, J., Tian, S., Decker, P. A., Eckel-Passow, J. E., Kitange, G. J., Johnson, A. J., Parney, I. F., Anastasiadis, P. Z. & 3 others, Agar, N. Y. R., Elmquist, W. F. & Sarkaria, J. N., Sep 1 2018, In : Molecular Cancer Therapeutics. 17, 9, p. 1893-1901 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
Pharmaceutical Preparations
Gadolinium
Precision Medicine
11 Citations (Scopus)

H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

Fang, D., Gan, H., Cheng, L., Lee, J. H., Zhou, H., Sarkaria, J. N., Daniels, D. & Zhang, Z., Jun 22 2018, In : eLife. 7, e36696.

Research output: Contribution to journalArticle

Mutant Proteins
Tumor Suppressor Genes
Glioma
Tumors
Wilms Tumor

Hypoxia-inducible factor 2α: A novel target in gliomas

Renfrow, J. J., Soike, M. H., Debinski, W., Ramkissoon, S. H., Mott, R. T., Frenkel, M. B., Sarkaria, J. N., Lesser, G. J. & Strowd, R. E., Sep 1 2018, In : Future Medicinal Chemistry. 10, 18, p. 2227-2236 10 p.

Research output: Contribution to journalArticle

Glioma
Glioblastoma
Renal Cell Carcinoma
Transcription Factors
Up-Regulation
Insulin-Like Growth Factor Binding Protein 6
temozolomide
Oncology
Somatomedins
Glioblastoma
4 Citations (Scopus)

Influence of hyaluronic acid transitions in tumor microenvironment on glioblastoma malignancy and invasive behavior

Chen, J. W. E., Pedron, S., Shyu, P., Hu, Y., Sarkaria, J. N. & Harley, B. A. C., Jun 26 2018, In : Frontiers in Materials. 5, 39.

Research output: Contribution to journalArticle

Open Access
Hyaluronic acid
Hyaluronic Acid
Tumors
Molecular weight
Hydrogels
7 Citations (Scopus)

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Randall, E. C., Emdal, K. B., Laramy, J. K., Kim, M., Roos, A., Calligaris, D., Regan, M. S., Gupta, S. K., Mladek, A. C., Carlson, B. L., Johnson, A. J., Lu, F. K., Xie, X. S., Joughin, B. A., Reddy, R. J., Peng, S., Abdelmoula, W. M., Jackson, P. R., Kolluri, A., Kellersberger, K. A. & 8 others, Agar, J. N., Lauffenburger, D. A., Swanson, K., Tran, N., Elmquist, W. F., White, F. M., Sarkaria, J. N. & Agar, N. Y. R., Dec 1 2018, In : Nature Communications. 9, 1, 4904.

Research output: Contribution to journalArticle

Pharmacodynamics
Pharmacokinetics
Glioblastoma
Heterografts
drugs
37 Citations (Scopus)

Is the blood-brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

Sarkaria, J. N., Hu, L. S., Parney, I. F., Pafundi, D. H., Brinkmann, D. H., Laack, N. N., Giannini, C., Burns, T., Kizilbash, S., Laramy, J. K., Swanson, K., Kaufmann, T. J., Brown, P. D., Agar, N. Y. R., Galanis, E., Buckner, J. C. & Elmquist, W. F., Jan 22 2018, In : Neuro-Oncology. 20, 2, p. 184-191 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Blood-Brain Barrier
Pharmaceutical Preparations
Neoplasms
Brain
11 Citations (Scopus)

LPA signaling is regulated through the primary cilium: a novel target in glioblastoma

Loskutov, Y. V., Griffin, C. L., Marinak, K. M., Bobko, A., Margaryan, N. V., Geldenhuys, W. J., Sarkaria, J. N. & Pugacheva, E. N., Jan 11 2018, (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

Cilia
Glioblastoma
Lysophosphatidic Acid Receptors
Astrocytes
Neoplasms
5 Citations (Scopus)

Modeling the diffusion of D-2-hydroxyglutarate from IDH1 mutant gliomas in the central nervous system

Linninger, A., Hartung, G. A., Liu, B. P., Mirkov, S., Tangen, K., Lukas, R. V., Unruh, D., David James, C., Sarkaria, J. N. & Horbinski, C., Jan 1 2018, In : Neuro-Oncology. 20, 9, p. 1197-1206 10 p.

Research output: Contribution to journalArticle

Glioma
Central Nervous System
Liquid Chromatography
Mass Spectrometry
alpha-hydroxyglutarate
2 Citations (Scopus)

Molecular and structural traits of insulin receptor substrate 1/LC3 nuclear structures and their role in autophagy control and tumor cell survival

Lassak, A., Dean, M., Wyczechowsk, D., Wilk, A., Marrero, L., Trillo-Tinoco, J., Hamid Boulares, A., Sarkaria, J. N., Valle, L. D., Peruzzi, F., Ochoa, A. & Reiss, K., May 1 2018, In : Molecular and Cellular Biology. 38, 10, e00608.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Autophagy
Cell Survival
Neoplasms
alpha Karyopherins
7 Citations (Scopus)

NOTCH3 expression is linked to breast cancer seeding and distant metastasis

Leontovich, A. A., Jalalirad, M., Salisbury, J. L., Mills, L., Haddox, C., Schroeder, M., Tuma, A., Guicciardi, M. E., Zammataro, L., Gambino, M. W., Amato, A., Di Leonardo, A., McCubrey, J., Lange, C. A., Liu, M. C., Haddad, T. C., Goetz, M. P., Boughey, J. C., Sarkaria, J. N., Wang, L. M. & 3 others, Ingle, J. N., Galanis, E. & D'Assoro, A., Sep 4 2018, In : Breast Cancer Research. 20, 1, 105.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Phenotype

Pharmacokinetic assessment of cooperative efflux of the multitargeted kinase inhibitor ponatinib across the blood-brain barrier

Laramy, J. K., Kim, M., Parrish, K. E., Sarkaria, J. N. & Elmquist, W. F., May 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 2, p. 249-261 13 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Phosphotransferases
Pharmacokinetics
Brain
Knockout Mice
6 Citations (Scopus)

Phase 1/2 trial of temsirolimus and sorafenib in the treatment of patients with recurrent glioblastoma: North Central Cancer Treatment Group Study/Alliance N0572

Schiff, D., Jaeckle, K. A., Anderson, S. K., Galanis, E., Giannini, C., Buckner, J. C., Stella, P., Flynn, P. J., Erickson, B. J., Schwerkoske, J. F., Kaluza, V., Twohy, E., Dancey, J., Wright, J. & Sarkaria, J. N., Apr 1 2018, In : Cancer. 124, 7, p. 1455-1463 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Vascular Endothelial Growth Factor A
Neoplasms
Maximum Tolerated Dose
temozolomide
6 Citations (Scopus)

Phase I/II trial of vorinostat combined with temozolomide and radiation therapy for newly diagnosed glioblastoma: Results of Alliance N0874/ABTC 02

Galanis, E., Keith Anderson, S., Miller, C. R., Sarkaria, J. N., Jaeckle, K., Buckner, J. C., Ligon, K. L., Ballman, K. V., Moore, D. F., Nebozhyn, M., Loboda, A., Schiff, D., Ahluwalia, M. S., Lee, E. Q., Gerstner, E. R., Lesser, G. J., Prados, M., Grossman, S. A., Cerhan, J. H., Giannini, C. & 1 others, Wen, P. Y., Mar 27 2018, In : Neuro-Oncology. 20, 4, p. 546-556 11 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Radiotherapy
Neutropenia
Disease-Free Survival
6 Citations (Scopus)

Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition

Marisol Herrera-Perez, R., Voytik-Harbin, S. L., Sarkaria, J. N., Pollok, K. E., Fishel, M. L. & Rickus, J. L., Mar 1 2018, In : PLoS One. 13, 3, e0194183.

Research output: Contribution to journalArticle

Tumor Microenvironment
stromal cells
Glioblastoma
Stromal Cells
Tumors
2017
9 Citations (Scopus)

Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patientderived GBM tumor cells

Tivnan, A., Heilinger, T., Ramsey, J. M., O'Connor, G., Pokorny, J. L., Sarkaria, J. N., Stringer, B. W., Day, B. W., Boyd, A. W., Kim, E. L., Lode, H. N., Cryan, S. A. & Prehn, J. H. M., 2017, In : Oncotarget. 8, 10, p. 16605-16620 16 p.

Research output: Contribution to journalArticle

letrozole
Aromatase Inhibitors
Glioblastoma
Nanoparticles
Aromatase
23 Citations (Scopus)

A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma

Guo, G., Gong, K., Ali, S., Ali, N., Shallwani, S., Hatanpaa, K. J., Pan, E., Mickey, B., Burma, S., Wang, D. H., Kesari, S., Sarkaria, J. N., Zhao, D. & Habib, A. A., Aug 1 2017, In : Nature Neuroscience. 20, 8, p. 1074-1084 11 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
Glioblastoma
Epidermal Growth Factor Receptor
Tumor Necrosis Factor-alpha
3 Citations (Scopus)

CD90 expression controls migration and predicts dasatinib response in glioblastoma

Avril, T., Etcheverry, A., Pineau, R., Obacz, J., Jegou, G., Jouan, F., Le Reste, P. J., Hatami, M., Colen, R. R., Carlson, B. L., Decker, P. A., Sarkaria, J. N., Vauléon, E., Chiforeanu, D. C., Clavreul, A., Mosser, J., Chevet, E. & Quillien, V., Dec 1 2017, In : Clinical Cancer Research. 23, 23, p. 7360-7374 15 p.

Research output: Contribution to journalArticle

Glioblastoma
Stem Cells
Dasatinib
Transcriptome
Heterografts
4 Citations (Scopus)

Characterization of relative biological effectiveness for conventional radiation therapy: A comparison of clinical 6 MV X-rays and 137Cs

Howard, M., Beltran, C., Sarkaria, J. N. & Herman, M. G., Sep 1 2017, In : Journal of Radiation Research. 58, 5, p. 608-613 6 p.

Research output: Contribution to journalArticle

Relative Biological Effectiveness
radiation therapy
Radiotherapy
X-Rays
Radiation
8 Citations (Scopus)

Combination therapy in a xenograft model of glioblastoma: Enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

Wang, H., Cai, S., Bailey, B. J., Saadatzadeh, M. R., Ding, J., Tonsing-Carter, E., Georgiadis, T. M., Gunter, T. Z., Long, E. C., Minto, R. E., Gordon, K. R., Sen, S. E., Cai, W., Eitel, J. A., Waning, D. L., Bringman, L. R., Wells, C. D., Murray, M. E., Sarkaria, J. N., Gelbert, L. M. & 5 others, Jones, D. R., Cohen-Gadol, A. A., Mayo, L. D., Shannon, H. E. & Pollok, K. E., Feb 1 2017, In : Journal of Neurosurgery. 126, 2, p. 446-459 14 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Heterografts
Therapeutics
Growth
14 Citations (Scopus)

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

McNeill, R. S., Canoutas, D. A., Stuhlmiller, T. J., Dhruv, H. D., Irvin, D. M., Bash, R. E., Angus, S. P., Herring, L. E., Simon, J. M., Skinner, K. R., Limas, J. C., Chen, X., Schmid, R. S., Siegel, M. B., Van Swearingen, A. E. D., Hadler, M. J., Sulman, E. P., Sarkaria, J. N., Anders, C. K., Graves, L. M. & 3 others, Berens, M. E., Johnson, G. L. & Miller, C. R., Nov 1 2017, In : Neuro-Oncology. 19, 11, p. 1469-1480 12 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Glioblastoma
Protein Kinase Inhibitors
Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase Kinases
24 Citations (Scopus)

DNA repair capacity in multiple pathways predicts chemoresistance in glioblastoma multiforme

Nagel, Z. D., Kitange, G. J., Gupta, S. K., Joughin, B. A., Chaim, I. A., Mazzucato, P., Lauffenburger, D. A., Sarkaria, J. N. & Samson, L. D., Jan 1 2017, In : Cancer Research. 77, 1, p. 198-206 9 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
DNA Repair
DNA
Methyltransferases
8 Citations (Scopus)

Drug delivery to melanoma brain metastases: Can current challenges lead to new opportunities?

Gampa, G., Vaidhyanathan, S., Sarkaria, J. N. & Elmquist, W. F., Sep 1 2017, In : Pharmacological Research. 123, p. 10-25 16 p.

Research output: Contribution to journalArticle

Melanoma
Neoplasm Metastasis
Brain
Pharmaceutical Preparations
Blood-Brain Barrier
8 Citations (Scopus)

EGFR signals through a DOCK180-MLK3 axis to drive glioblastoma cell invasion

Misek, S. A., Chen, J., Schroeder, L., Rattanasinchai, C., Sample, A., Sarkaria, J. N. & Gallo, K. A., Aug 1 2017, In : Molecular Cancer Research. 15, 8, p. 1085-1095 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Epidermal Growth Factor
Cell Movement
Neoplasms
MAP Kinase Kinase Kinases
12 Citations (Scopus)

Extracellular Hyaluronic Acid Influences the Efficacy of EGFR Tyrosine Kinase Inhibitors in a Biomaterial Model of Glioblastoma

Pedron, S., Hanselman, J. S., Schroeder, M. A., Sarkaria, J. N. & Harley, B. A. C., 2017, (Accepted/In press) In : Advanced healthcare materials.

Research output: Contribution to journalArticle

Hyaluronic acid
Biocompatible Materials
Hyaluronic Acid
Glioblastoma
Epidermal Growth Factor Receptor
27 Citations (Scopus)

Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma

Cosset, É., Ilmjärv, S., Dutoit, V., Elliott, K., von Schalscha, T., Camargo, M. F., Reiss, A., Moroishi, T., Seguin, L., Gomez, G., Moo, J. S., Preynat-Seauve, O., Krause, K. H., Chneiweiss, H., Sarkaria, J. N., Guan, K. L., Dietrich, P. Y., Weis, S. M., Mischel, P. S. & Cheresh, D. A., Dec 11 2017, In : Cancer Cell. 32, 6, p. 856-868.e5

Research output: Contribution to journalArticle

Glioblastoma
Integrins
Facilitative Glucose Transport Proteins
Neoplastic Stem Cells
Transcriptome
8 Citations (Scopus)

Heterogeneous binding and central nervous system distribution of the multitargeted kinase inhibitor ponatinib restrict orthotopic efficacy in a patient-derived xenograft model of glioblastoma

Laramy, J. K., Kim, M., Gupta, S. K., Parrish, K. E., Zhang, S., Bakken, K. K., Carlson, B. L., Mladek, A. C., Ma, D. J., Sarkaria, J. N. & Elmquist, W. F., Nov 1 2017, In : Journal of Pharmacology and Experimental Therapeutics. 363, 2, p. 136-147 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
Phosphotransferases
Central Nervous System
Brain Neoplasms
26 Citations (Scopus)

Immunovirotherapy with measles virus strains in combination with anti-PD-1 antibody blockade enhances antitumor activity in glioblastoma treatment

Hardcastle, J., Mills, L., Malo, C. S., Jin, F., Kurokawa, C., Geekiyanage, H., Schroeder, M., Sarkaria, J. N., Johnson, A. J. & Galanis, E., Apr 1 2017, In : Neuro-Oncology. 19, 4, p. 493-502 10 p.

Research output: Contribution to journalArticle

Programmed Cell Death 1 Receptor
Measles virus
Glioblastoma
Antibodies
Glioma
9 Citations (Scopus)

Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells

Mamo, T., Mladek, A. C., Shogren, K. L., Gustafson, C., Gupta, S. K., Riester, S. M., Maran, A., Galindo, M., van Wijnen, A. J., Sarkaria, J. N. & Yaszemski, M. J., Apr 29 2017, In : Biochemical and Biophysical Research Communications. 486, 2, p. 307-313 7 p.

Research output: Contribution to journalArticle

lysyl-arginyl-alanyl-lysyl-alanyl-lysyl-threonyl-threonyl-lysyl-lysyl-arginine
Osteosarcoma
DNA
Cells
Cell Line
6 Citations (Scopus)

Macropinocytosis of bevacizumab by glioblastoma cells in the perivascular niche affects their survival

Müller-Greven, G., Carlin, C. R., Burgett, M. E., Ahluwalia, M. S., Lauko, A., Nowacki, A. S., Herting, C. J., Qadan, M. A., Bredel, M., Toms, S. A., Lathia, J. D., Hambardzumyan, D., Sarkaria, J. N., Hamerlik, P. & Gladson, C. L., Nov 15 2017, In : Clinical Cancer Research. 23, 22, p. 7059-7071 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival
Vascular Endothelial Growth Factor A
Autophagy
Cell Survival
5 Citations (Scopus)

Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix

Heim, J. B., Squirewell, E. J., Neu, A., Zocher, G., Sominidi-Damodaran, S., Wyles, S. P., Nikolova, E., Behrendt, N., Saunte, D. M., Lock-Andersen, J., Gaonkar, K. S., Yan, H. D., Sarkaria, J. N., Krendel, M., Van Deursen, J., Sprangers, R., Stehle, T., Böttcher, R. T., Lee, J. H., Ordog, T. & 1 others, Meves, A., Apr 11 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 15, p. 3933-3938 6 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Myosins
Fibronectins
Proline
Phosphotransferases