• 14465 Citations
  • 54 Scopus h-Index
1993 …2020

Research output per year

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Research Output

2015

Improving drug delivery to primary and metastatic brain tumors: strategies to overcome the blood-brain barrier

Parrish, K. E., Sarkaria, J. N. & Elmquist, W. F., Apr 1 2015, In : Clinical Pharmacology and Therapeutics. 97, 4, p. 336-346 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme

Tivnan, A., Zakaria, Z., O'Leary, C., Kögel, D., Pokorny, J. L., Sarkaria, J. N. & Prehn, J. H. M., 2015, In : Frontiers in Neuroscience. 9, MAY, 218.

Research output: Contribution to journalArticle

48 Scopus citations

MARQUIS: A multiplex method for absolute quantification of peptides and posttranslational modifications

Curran, T. G., Zhang, Y., Ma, D. J., Sarkaria, J. N. & White, F. M., Jan 2015, In : Nature communications. 6, 5924.

Research output: Contribution to journalArticle

26 Scopus citations

Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Gaw, N., Dueck, A. C., Smith, K. A., Nakaji, P., Plasencia, J., Ranjbar, S., Price, S. J., Tran, N., Loftus, J., Jenkins, R., O'Neill, B. P., Elmquist, W., Baxter, L. C., Gao, F., Frakes, D., Karis, J. P., Zwart, C. & 5 others, Swanson, K. R., Sarkaria, J., Wu, T., Mitchell, J. R. & Li, J., Nov 1 2015, In : PloS one. 10, 11, e0141506.

Research output: Contribution to journalArticle

54 Scopus citations

Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition

Shen, Y., Li, J., Nitta, M., Futalan, D., Steed, T., Treiber, J. M., Taich, Z., Stevens, D., Wykosky, J., Chen, H. Z., Carter, B. S., Becher, O. J., Kennedy, R., Esashi, F., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K., Desai, A. & Chen, C. C., 2015, In : Oncotarget. 6, 14, p. 11751-11767 17 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α

Feng, H., Li, Y., Yin, Y., Zhang, W., Hou, Y., Zhang, L., Li, Z., Xie, B., Gao, W. Q., Sarkaria, J. N., Raizer, J. J., James, C. D., Parsa, A. T., Hu, B. & Cheng, S. Y., Jan 1 2015, In : Neuro-oncology. 17, 6, p. 832-842 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
13 Scopus citations

Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

Kitange, G. J., Mladek, A. C., Schroeder, M. A., Pokorny, J. C., Carlson, B. L., Zhang, Y., Nair, A. A., Lee, J. H., Yan, H. D., Decker, P. A., Zhang, Z. & Sarkaria, J. N., Mar 4 2015, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

25 Scopus citations

Src family kinases differentially influence glioma growth and motility

Lewis-Tuffin, L. J., Feathers, R., Hari, P., Durand, N., Li, Z., Rodriguez, F. J., Bakken, K., Carlson, B., Schroeder, M., Sarkaria, J. N. & Anastasiadis, P. Z., Nov 1 2015, In : Molecular Oncology. 9, 9, p. 1783-1798 16 p.

Research output: Contribution to journalArticle

24 Scopus citations

The bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation

Pastori, C., Kapranov, P., Penas, C., Peschansky, V., Volmar, C. H., Sarkaria, J. N., Bregy, A., Komotar, R., Laurent, G. S., Ayad, N. G., Wahlestedt, C. & Roberts, T. C., Jul 7 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8326-8331 6 p.

Research output: Contribution to journalArticle

104 Scopus citations

The efficacy of the wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma

Pokorny, J. L., Calligaris, D., Gupta, S. K., Iyekegbe, D. O., Mueller, D., Bakken, K. K., Carlson, B. L., Schroeder, M. A., Evans, D. L., Lou, Z., Decker, P. A., Eckel-Passow, J. E., Pucci, V., Ma, B., Shumway, S. D., Elmquist, W. F., Agar, N. Y. R. & Sarkaria, J. N., Apr 15 2015, In : Clinical Cancer Research. 21, 8, p. 1916-1924 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody

Zhu, S., Kisiel, W., Lu, Y. J., Petersen, L. C., Ndungu, J. M., Moore, T. W., Parker, E. T., Sun, A., Sarkaria, J. N., Snyder, J. P., Liotta, D. C., Brat, D. J., El-Rayes, B. F. & Shoji, M., Apr 1 2015, In : Journal of Drug Targeting. 23, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2014

A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas

Kushwaha, D., Ramakrishnan, V., Ng, K., Steed, T., Nguyen, T., Futalan, D., Akers, J. C., Sarkaria, J., Jiang, T., Chowdhury, D., Carter, B. S. & Chen, C. C., 2014, In : Oncotarget. 5, 12, p. 4026-4039 14 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations

A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death

Shing, J. C., Choi, J. W., Chapman, R., Schroeder, M. A., Sarkaria, J. N., Fauq, A. & Bram, R. J., Jul 2014, In : Cancer Biology and Therapy. 15, 7, p. 895-905 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

BET bromodomain proteins are required for glioblastoma cell proliferation

Pastori, C., Daniel, M., Penas, C., Volmar, C. H., Johnstone, A. L., Brothers, S. P., Graham, R. M., Allen, B., Sarkaria, J. N., Komotar, R. J., Wahlestedt, C. & Ayad, N. G., Feb 19 2014, In : Epigenetics. 9, 4, p. 611-620 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Cyclophilin B supports MYC and mutant p53-dependent survival of glioblastoma multiforme cells

Choi, J. W., Schroeder, M. A., Sarkaria, J. N. & Bram, R. J., Jan 15 2014, In : Cancer research. 74, 2, p. 484-496 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Design and characterization of an economical 192Ir hemi-brain small animal irradiator

Grams, M. P., Wilson, Z. C., Sio, T. T., Beltran, C. J., Tryggestad, E. J., Gupta, S. K., Blackwell, C. R., McCollough, K. P., Sarkaria, J. N. & Furutani, K. M., Oct 1 2014, In : International Journal of Radiation Biology. 90, 10, p. 936-942 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts

Gupta, S. K., Mladek, A. C., Carlson, B. L., Boakye-Agyeman, F., Bakken, K. K., Kizilbash, S. H., Schroeder, M. A., Reid, J. & Sarkaria, J. N., Jul 15 2014, In : Clinical Cancer Research. 20, 14, p. 3730-3741 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180

Feng, H., Hu, B., Vuori, K., Sarkaria, J. N., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., May 8 2014, In : Oncogene. 33, 19, p. 2504-2512 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Factors influencing the CNS distribution of a novel MEK-1/2 inhibitor: Implications for combination therapy for melanoma brain metastases

Vaidhyanathan, S., Mittapalli, R. K., Sarkaria, J. N. & Elmquist, W. F., Aug 2014, In : Drug Metabolism and Disposition. 42, 8, p. 1292-1300 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

NT113, A pan-ERBB inhibitor with high brain penetrance, inhibits the growth of glioblastoma xenografts with EGFR amplification

Yoshida, Y., Ozawa, T., Yao, T. W., Shen, W., Brown, D., Parsa, A. T., Raizer, J. J., Cheng, S. Y., Stegh, A. H., Mazar, A. P., Giles, F. J., Sarkaria, J. N., Butowski, N., Nicolaides, T. & James, C. D., Dec 1 2014, In : Molecular cancer therapeutics. 13, 12, p. 2919-2929 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
39 Scopus citations
13 Scopus citations

Tumorgrafts as in vivo surrogates for women with ovarian cancer

Weroha, S. J., Becker, M. A., Enderica-Gonzalez, S., Harrington, S. C., Oberg, A. L., Maurer, M. J., Perkins, S. E., AlHilli, M., Butler, K. A., McKinstry, S., Fink, S., Jenkins, R. B., Hou, X., Kalli, K. R., Goodman, K. M., Sarkaria, J. N., Karlan, B. Y., Kumar, A., Kaufmann, S. H., Hartmann, L. C. & 1 others, Haluska, P., Jan 1 2014, In : Clinical Cancer Research. 20, 5, p. 1288-1297 10 p.

Research output: Contribution to journalArticle

91 Scopus citations
2013

Biopsy validation of 18F-DOPA PET and biodistribution in gliomas for neurosurgical planning and radiotherapy target delineation: Results of a prospective pilot study

Pafundi, D. H., Laack, N. N., Youland, R. S., Parney, I. F., Lowe, V. J., Giannini, C., Kemp, B. J., Grams, M. P., Morris, J. M., Hoover, J. M., Hu, L. S., Sarkaria, J. N. & Brinkmann, D. H., Aug 1 2013, In : Neuro-oncology. 15, 8, p. 1058-1067 10 p.

Research output: Contribution to journalReview article

92 Scopus citations

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

Flavahan, W. A., Wu, Q., Hitomi, M., Rahim, N., Kim, Y., Sloan, A. E., Weil, R. J., Nakano, I., Sarkaria, J. N., Stringer, B. W., Day, B. W., Li, M., Lathia, J. D., Rich, J. N. & Hjelmeland, A. B., Oct 1 2013, In : Nature Neuroscience. 16, 10, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

216 Scopus citations

Brain tumor stem cell multipotency correlates with nanog expression and extent of passaging in human glioblastoma xenografts

Higgins, D. M., Wang, R., Milligan, B., Schroeder, M., Carlson, B., Pokorny, J., Cheshier, S. H., Meyer, F. B., Weissman, I. L., Sarkaria, J. N. & Henley, J. R., May 2013, In : Oncotarget. 4, 5, p. 792-801 10 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models

Cen, L., Carlson, B. L., Pokorny, J. L., Mladek, A. C., Grogan, P. T., Schroeder, M. A., Decker, P. A., Anderson, S. K., Giannini, C., Wu, W., Ballman, K. V., Kitange, G. J. & Sarkaria, J. N., Jun 2013, In : Neuro-oncology. 15, 6, p. 735-746 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Impairment of glioma stem cell survival and growth by a novel inhibitor for survivin-ran protein complex

Guvenc, H., Pavlyukov, M. S., Joshi, K., Kurt, H., Banasavadi-Siddegowda, Y. K., Mao, P., Hong, C., Yamada, R., Kwon, C. H., Bhasin, D., Chettiar, S., Kitange, G., Park, I. H., Sarkaria, J. N., Li, C., Shakhparonov, M. I. & Nakano, I., Feb 1 2013, In : Clinical Cancer Research. 19, 3, p. 631-642 12 p.

Research output: Contribution to journalArticle

55 Scopus citations

Increased bowel toxicity in patients treated with a vascular endothelial growth factor inhibitor (VEGFI) after stereotactic body radiation therapy (SBRT)

Barney, B. M., Markovic, S. N., Laack, N. N., Miller, R. C., Sarkaria, J. N., Macdonald, O. K., Bauer, H. J. & Olivier, K. R., Sep 1 2013, In : International Journal of Radiation Oncology Biology Physics. 87, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Oncolytic measles virus strains have significant antitumor activity against glioma stem cells

Allen, C., Opyrchal, M., Aderca, I., Schroeder, M. A., Sarkaria, J. N., Domingo, E., Federspiel, M. J. & Galanis, E., Apr 1 2013, In : Gene Therapy. 20, 4, p. 444-449 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Opportunities and challenges in the era of molecularly targeted agents and radiation therapy

Lin, S. H., George, T. J., Ben-Josef, E., Bradley, J., Choe, K. S., Edelman, M. J., Guha, C., Krishnan, S., Lawrence, T. S., Le, Q. T., Lu, B., Mehta, M., Peereboom, D., Sarkaria, J., Seong, J., Wang, D., Welliver, M. X., Coleman, C. N., Vikram, B., Yoo, S. & 1 others, Chung, C. H., May 15 2013, In : Journal of the National Cancer Institute. 105, 10, p. 686-693 8 p.

Research output: Contribution to journalReview article

35 Scopus citations

P53 isoform profiling in glioblastoma and injured brain

Takahashi, R., Giannini, C., Sarkaria, J. N., Schroeder, M., Rogers, J., Mastroeni, D. & Scrable, H., Jun 27 2013, In : Oncogene. 32, 26, p. 3165-3174 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Posttranscriptional regulation of per1 underlies the oncogenic function of IREα

Pluquet, O., Dejeans, N., Bouchecareilh, M., Lhomond, S., Pineau, R., Higa, A., Delugin, M., Combe, C., Loriot, S., Cubel, G., Dugot-Senant, N., Vital, A., Loiseau, H., Gosline, S. J. C., Taouji, S., Hallett, M., Sarkaria, J. N., Anderson, K., Wu, W., Rodriguez, F. J. & 4 others, Rosenbaum, J., Saltel, F., Fernandez-Zapico, M. E. & Chevet, E., Aug 1 2013, In : Cancer research. 73, 15, p. 4732-4743 12 p.

Research output: Contribution to journalArticle

73 Scopus citations

Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion

Huveldt, D., Lewis-Tuffin, L. J., Carlson, B. L., Schroeder, M. A., Rodriguez, F., Giannini, C., Galanis, E., Sarkaria, J. N. & Anastasiadis, P. Z., Feb 14 2013, In : PloS one. 8, 2, e56505.

Research output: Contribution to journalArticle

54 Scopus citations

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

Chan, K. M., Fang, D., Gan, H., Hashizume, R., Yu, C., Schroeder, M., Gupta, N., Mueller, S., David James, C., Jenkins, R., Sarkaria, J. & Zhang, Z., May 1 2013, In : Genes and Development. 27, 9, p. 985-990 6 p.

Research output: Contribution to journalArticle

327 Scopus citations

The role of LAT1 in 18F-DOPA uptake in malignant gliomas

Youland, R. S., Kitange, G. J., Peterson, T. E., Pafundi, D. H., Ramiscal, J. A., Pokorny, J. L., Giannini, C., Laack, N. N., Parney, I. F., Lowe, V. J., Brinkmann, D. H. & Sarkaria, J. N., Jan 1 2013, In : Journal of neuro-oncology. 111, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

67 Scopus citations
2012

Active efflux of dasatinib from the brain limits efficacy against murine glioblastoma: Broad implications for the clinical use of molecularly targeted agents

Agarwal, S., Mittapalli, R. K., Zellmer, D. M., Gallardo, J. L., Donelson, R., Seiler, C., Decker, S. A., SantaCruz, K. S., Pokorny, J. L., Sarkaria, J. N., Elmquist, W. F. & Ohlfest, J. R., Oct 2012, In : Molecular cancer therapeutics. 11, 10, p. 2183-2192 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Alkylpurine - DNA - N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

Agnihotri, S., Gajadhar, A. S., Ternamian, C., Gorlia, T., Diefes, K. L., Mischel, P. S., Kelly, J., McGown, G., Thorncroft, M., Carlson, B. L., Sarkaria, J. N., Margison, G. P., Aldape, K., Hawkins, C., Hegi, M. & Guha, A., Jan 3 2012, In : Journal of Clinical Investigation. 122, 1, p. 253-266 14 p.

Research output: Contribution to journalArticle

83 Scopus citations

ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells

Nadkarni, A., Shrivastav, M., Mladek, A. C., Schwingler, P. M., Grogan, P. T., Chen, J. & Sarkaria, J. N., Dec 1 2012, In : Journal of neuro-oncology. 110, 3, p. 349-357 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Erratum: Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients (Journal of Clinical Investigation (2012) 122, 1, (253-266) DOI: 10.1172/JCI59334)

Agnihotri, S., Gajadhar, A. S., Ternamian, C., Gorlia, T., Diefes, K. L., Mischel, P. S., Kelly, J., McGown, G., Thorncroft, M., Carlson, B. L., Sarkaria, J. N., Margison, G. P., Aldape, K., Hawkins, C., Hegi, M. & Guha, A., Feb 2012, In : Journal of Clinical Investigation. 122, 2, 1 p.

Research output: Contribution to journalComment/debate

Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts

Kitange, G. J., Mladek, A. C., Carlson, B. L., Schroeder, M. A., Pokorny, J. L., Cen, L., Decker, P. A., Wu, W. D., Lomberk, G. A., Gupta, S. K., Urrutia, R. A. & Sarkaria, J. N., Aug 1 2012, In : Clinical Cancer Research. 18, 15, p. 4070-4079 10 p.

Research output: Contribution to journalArticle

74 Scopus citations

Molecular characterization of EGFR and EGFRvIII signaling networks in human glioblastoma tumor xenografts

Johnson, H., Del Rosario, A. M., Bryson, B. D., Schroeder, M. A., Sarkaria, J. N. & White, F. M., Dec 2012, In : Molecular and Cellular Proteomics. 11, 12, p. 1724-1740 17 p.

Research output: Contribution to journalArticle

59 Scopus citations

P16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells

Cen, L., Carlson, B. L., Schroeder, M. A., Ostrem, J. L., Kitange, G. J., Mladek, A. C., Fink, S. R., Decker, P. A., Wu, W., Kim, J. S., Waldman, T., Jenkins, R. B. & Sarkaria, J. N., Jul 2012, In : Neuro-oncology. 14, 7, p. 870-881 12 p.

Research output: Contribution to journalArticle

96 Scopus citations

Phase i study of temsirolimus in combination with EKB-569 in patients with advanced solid tumors

Bryce, A. H., Rao, R., Sarkaria, J., Reid, J. M., Qi, Y., Qin, R., James, C. D., Jenkins, R. B., Boni, J., Erlichman, C. & Haluska, P., Oct 1 2012, In : Investigational New Drugs. 30, 5, p. 1934-1941 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

Feng, H., Hu, B., Jarzynka, M. J., Li, Y., Keezer, S., Johns, T. G., Tang, C. K., Hamilton, R. L., Vuori, K., Nishikawa, R., Sarkaria, J. N., Fenton, T., Cheng, T., Furnari, F. B., Cavenee, W. K. & Cheng, S. Y., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 3018-3023 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Targeting the PI3K pathway in the brain - Efficacy of a PI3K inhibitor optimized to cross the blood-brain barrier

Salphati, L., Heffron, T. P., Alicke, B., Nishimura, M., Barck, K., Carano, R. A., Cheong, J., Edgar, K. A., Greve, J., Kharbanda, S., Koeppen, H., Lau, S., Lee, L. B., Pang, J., Plise, E. G., Pokorny, J. L., Reslan, H. B., Sarkaria, J. N., Wallin, J. J., Zhang, X. & 3 others, Gould, S. E., Olivero, A. G. & Phillips, H. S., Nov 15 2012, In : Clinical Cancer Research. 18, 22, p. 6239-6248 10 p.

Research output: Contribution to journalArticle

49 Scopus citations
2011

Activation of Rac1 by Src-dependent phosphorylation of Dock180 Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

Feng, H., Hu, B., Liu, K. W., Li, Y., Lu, X., Cheng, T., Yiin, J. J., Lu, S., Keezer, S., Fenton, T., Furnari, F. B., Hamilton, R. L., Vuori, K., Sarkaria, J. N., Nagane, M., Nishikawa, R., Cavenee, W. K. & Cheng, S. Y., Dec 1 2011, In : Journal of Clinical Investigation. 121, 12, p. 4670-4684 15 p.

Research output: Contribution to journalArticle

80 Scopus citations

A phase 2 study of temsirolimus (CCI-779) in patients with soft tissue sarcomas: A study of the mayo phase 2 Consortium (P2C)

Okuno, S., Bailey, H., Mahoney, M. R., Adkins, D., Maples, W., Fitch, T., Ettinger, D., Erlichman, C. & Sarkaria, J. N., Aug 1 2011, In : Cancer. 117, 15, p. 3468-3475 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Effective radiovirotherapy for malignant gliomas by using oncolytic measles virus strains encoding the sodium iodide symporter (MV-NIS)

Opyrchal, M., Allen, C., Iankov, I., Aderca, I., Schroeder, M., Sarkaria, J. & Galanis, E., Dec 20 2011, In : Human gene therapy. 23, 4, p. 419-427 9 p.

Research output: Contribution to journalArticle

27 Scopus citations