• 14927 Citations
  • 56 Scopus h-Index
1993 …2020

Research output per year

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Research Output

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

Jun, H. J., Appleman, V. A., Wu, H. J., Rose, C. M., Pineda, J. J., Yeo, A. T., Delcuze, B., Lee, C., Gyuris, A., Zhu, H., Woolfenden, S., Bronisz, A., Nakano, I., Chiocca, E. A., Bronson, R. T., Ligon, K. L., Sarkaria, J. N., Gygi, S. P., Michor, F., Mitchison, T. J. & 1 others, Charest, A., Dec 1 2018, In : Nature communications. 9, 1, 3116.

Research output: Contribution to journalArticle

6 Scopus citations

Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patientderived GBM tumor cells

Tivnan, A., Heilinger, T., Ramsey, J. M., O'Connor, G., Pokorny, J. L., Sarkaria, J. N., Stringer, B. W., Day, B. W., Boyd, A. W., Kim, E. L., Lode, H. N., Cryan, S. A. & Prehn, J. H. M., 2017, In : Oncotarget. 8, 10, p. 16605-16620 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death

Shing, J. C., Choi, J. W., Chapman, R., Schroeder, M. A., Sarkaria, J. N., Fauq, A. & Bram, R. J., Jul 2014, In : Cancer Biology and Therapy. 15, 7, p. 895-905 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

Chen, X., Zhang, M., Gan, H., Wang, H., Lee, J. H., Fang, D., Kitange, G. J., He, L., Hu, Z., Parney, I. F., Meyer, F. B., Giannini, C., Sarkaria, J. N. & Zhang, Z., Dec 1 2018, In : Nature communications. 9, 1, 2949.

Research output: Contribution to journalArticle

42 Scopus citations

An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth

Guessous, F., Zhang, F., DiPierro, C., Marcinkiewicz, L., Sarkaria, J., Schiff, D., Buchanan, S. & Abounader, R., Jan 2010, In : Anti-Cancer Agents in Medicinal Chemistry. 10, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Alkylpurine - DNA - N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

Agnihotri, S., Gajadhar, A. S., Ternamian, C., Gorlia, T., Diefes, K. L., Mischel, P. S., Kelly, J., McGown, G., Thorncroft, M., Carlson, B. L., Sarkaria, J. N., Margison, G. P., Aldape, K., Hawkins, C., Hegi, M. & Guha, A., Jan 3 2012, In : Journal of Clinical Investigation. 122, 1, p. 253-266 14 p.

Research output: Contribution to journalArticle

87 Scopus citations

Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma

Kurokawa, C., Geekiyanage, H., Allen, C., Iankov, I., Schroeder, M., Carlson, B., Bakken, K., Sarkaria, J., Ecsedy, J. A., D’Assoro, A., Friday, B. & Galanis, E., Jan 1 2017, In : Journal of neuro-oncology. 131, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas

Kushwaha, D., Ramakrishnan, V., Ng, K., Steed, T., Nguyen, T., Futalan, D., Akers, J. C., Sarkaria, J., Jiang, T., Chowdhury, D., Carter, B. S. & Chen, C. C., 2014, In : Oncotarget. 5, 12, p. 4026-4039 14 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

Active efflux of dasatinib from the brain limits efficacy against murine glioblastoma: Broad implications for the clinical use of molecularly targeted agents

Agarwal, S., Mittapalli, R. K., Zellmer, D. M., Gallardo, J. L., Donelson, R., Seiler, C., Decker, S. A., SantaCruz, K. S., Pokorny, J. L., Sarkaria, J. N., Elmquist, W. F. & Ohlfest, J. R., Oct 2012, In : Molecular cancer therapeutics. 11, 10, p. 2183-2192 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Activation of Rac1 by Src-dependent phosphorylation of Dock180 Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

Feng, H., Hu, B., Liu, K. W., Li, Y., Lu, X., Cheng, T., Yiin, J. J., Lu, S., Keezer, S., Fenton, T., Furnari, F. B., Hamilton, R. L., Vuori, K., Sarkaria, J. N., Nagane, M., Nishikawa, R., Cavenee, W. K. & Cheng, S. Y., Dec 1 2011, In : Journal of Clinical Investigation. 121, 12, p. 4670-4684 15 p.

Research output: Contribution to journalArticle

81 Scopus citations

Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain

Oliva, C. R., Nozell, S. E., Diers, A., McClugage, S. G., Sarkaria, J. N., Markert, J. M., Darley-Usmar, V. M., Bailey, S. M., Gillespie, G. Y., Landar, A. & Griguer, C. E., Dec 17 2010, In : Journal of Biological Chemistry. 285, 51, p. 39759-39767 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

A comparison of the efficacy and complication rates of low dose-rate versus high dose-rate brachytherapy in the treatment of uterine cervical carcinoma

Sarkaria, J. N., Petereit, D. G., Stitt, J. A., Hartman, T., Chappell, R., Thomadsen, B. R., Buchler, D. A., Fowler, J. F. & Kinsella, T. J., Aug 30 1994, In : International journal of radiation oncology, biology, physics. 30, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

52 Scopus citations

Ablation of neuropilin-1 improves the therapeutic response in conventional drug-resistant glioblastoma multiforme

Angom, R. S., Mondal, S. K., Wang, F., Madamsetty, V. S., Wang, E., Dutta, S. K., Gulani, Y., Sarabia Estrada, R., Sarkaria, J. N., Quiñones-Hinojosa, A. & Mukhopadhyay, D., 2020, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

4-Hydroxytamoxifen, an active metabolite of tamoxifen, does not alter the radiation sensitivity of MCF-7 breast carcinoma cells irradiated in vitro

Sarkaria, J. N., Miller, E. M., Parker, C. J., Jordan, V. C. & Mulcahy, R. T., Jan 1994, In : Breast Cancer Research and Treatment. 30, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

42 Scopus citations