Guojun D Bu, PhD

Professor

  • 14770 Citations
  • 71 h-Index
1985 …2020
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Projects 1985 2020

Integrative translational discovery of vascular risk factors in aging and dementia

Bu, G. D., Mangravite, L. & Ertekin-Taner, N.

National Institutes of Health

9/30/158/31/20

Project: Research projectMulti-Year Funded Research Project Grant

Cerebral Amyloid Angiopathy
Dementia
Alzheimer Disease
Apolipoproteins E
Amyloid Plaques
Apolipoprotein E4
Apolipoproteins E
Dendrites
Lipid Metabolism
Alzheimer Disease

MAYO ALZHEIMERS DISEASE RESEARCH CENTER

Petrucelli, L., Tangalos, E. G., Jack, C. R. J., Dickson, D. W., Boeve, B. F., Younkin, S. G., Kantarci, K. M., Smith, G. E., Rademakers, R. V., Petersen, R. C., Pankratz, V. S., Yen, S. C., Tangalos, E. G., Jack, C. R. J., Dickson, D. W., Vemuri, P. D., Lucas, J. A., Knopman, D. S., Hutton, M. L., Bu, G. D., Edland, S. D., Hutton, M. L., Clifford, J., Kokman, E., Ertekin-Taner, N., Hutton, M. L. & Ertekin-Taner, N.

National Institutes of Health

5/1/994/30/19

Project: Research projectSpecialized Center

Alzheimer Disease
Research
Dementia
Lewy Body Disease
Brain

ALZHEIMER'S DISEASE RESEARCH CENTER

Bu, G. D., Robins, L. E. E., Miller, T. M., Miller, J. P., Mintun, M. A., Harris, D., Snider, W., Edwards, D., Hale, S., Storandt, M., Schwartz, A., Miller, J. P., Mann Koepke, K., McKeel, D., Goate, A., Morris, J., Edwards, D., Hale, S., Schwartz, A., Merlie, J., Schmidt, D., Botwinick, J., Fagan, A., Denny, A., Willard, M., Toga, A., Musiek, E. S., Fulling, K., Cirrito, J., Robins, L. E. E., Schlesinger, M., Carr, D., O'Malley, K., Fischbach, G., Peck, W., Price, J., Olney, J., Berg, L., Snider, W., Miller, J. P., Mann Koepke, K., Buckner, R., Johnson, E., Holtzman, D., Cairns, N. J., Perrin, R. J., Galvin, J., Xiong, C., Miller, T. M., Goate, A., Morris, J., Kopan, R., Miller, J. P., Mintun, M. A., Meuser, T., Harris, D., McKeel, D., Miller, T. M. & Mintun, M. A.

National Institutes of Health

9/30/854/30/20

Project: Research projectSpecialized Center

Research Output 1992 2018

AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model

Hettinger, J. C., Lee, H., Bu, G. D., Holtzman, D. M. & Cirrito, J. R., May 15 2018, In : Molecular Neurodegeneration. 13, 1, 22.

Research output: Contribution to journalArticle

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Amyloid
Alzheimer Disease
Extracellular Fluid
AMPA Receptors
2 Citations

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Zhong, L., Wang, Z., Wang, D., Wang, Z., Martens, Y. A., Wu, L., Xu, Y., Wang, K., Li, J., Huang, R., Can, D., Xu, H., Bu, G. D. & Chen, X. F., Mar 27 2018, In : Molecular Neurodegeneration. 13, 1, 15.

Research output: Contribution to journalArticle

Myeloid Cells
Amyloid
Alzheimer Disease
Microglia
Cluster Analysis

A novel link between trafficking and Lewy body disorders

Ross, O. A. & Bu, G. D., Jul 1 2018, In : The Lancet Neurology. 17, 7, p. 571-573 3 p.

Research output: Contribution to journalComment/debate

Lewy Bodies

APOE ε2 is associated with increased tau pathology in primary tauopathy

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R. V., Murray, M. E., Koga, S. & 3 othersDickson, D. W., Ross, O. A. & Bu, G. D., Dec 1 2018, In : Nature communications. 9, 1, 4388.

Research output: Contribution to journalArticle

Tauopathies
pathology
Apolipoproteins E
Pathology
mice

APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

Dickson, D. W., Heckman, M. G., Murray, M. E., Soto, A. I., Walton, R. L., Diehl, N. N., Van Gerpen, J. A., Uitti, R. J., Wszolek, Z. K., Taner, N., Knopman, D. S., Petersen, R. C., Graff Radford, N. R., Boeve, B. F., Bu, G. D., Ferman, T. J. & Ross, O. A., Sep 18 2018, In : Neurology. 91, 12, p. e1182-e1195

Research output: Contribution to journalArticle

Lewy Bodies
Pathology
Alzheimer Disease
Dementia
Odds Ratio