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1985 …2020
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Research Output 1992 2019

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Article
2019

5-HT3 antagonist ondansetron increases apoE secretion by modulating the LXR-ABCA1 pathway

Shinohara, M., Shinohara, M., Zhao, J., Fu, Y., Liu, C-C., Kanekiyo, T. & Bu, G. D., Mar 2 2019, In : International Journal of Molecular Sciences. 20, 6, 1488.

Research output: Contribution to journalArticle

Open Access
Serotonin 5-HT3 Receptor Antagonists
Ondansetron
secretions
Apolipoproteins E
liver

A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II

Zhao, S., Li, Z., Zhang, M., Zhang, L., Zheng, H., Ning, J., Wang, Y., Wang, F., Zhang, X., Gan, H., Wang, Y., Zhang, X., Luo, H., Bu, G. D., Xu, H., Yao, Y. & Zhang, Y. W., Jul 1 2019, In : Experimental and Molecular Medicine. 51, 7, 84.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
Brain
Mutation
Electroencephalography
Neurons
2 Citations (Scopus)

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

Tachibana, M., Holm, M. L., Liu, C-C., Shinohara, M., Aikawa, T., Oue, H., Yamazaki, Y., Martens, Y. A., Murray, M. E., Sullivan, P. M., Weyer, K., Glerup, S., Dickson, D. W., Bu, G. D. & Kanekiyo, T., Mar 1 2019, In : Journal of Clinical Investigation. 129, 3, p. 1272-1277 6 p.

Research output: Contribution to journalArticle

LDL Receptors
Amyloid
Apolipoprotein E4
Pathology
Alzheimer Disease
4 Citations (Scopus)

Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression

Yamazaki, Y., Shinohara, M., Shinohara, M., Yamazaki, A., Murray, M. E., Liesinger, A. M., Heckman, M. G., Lesser, E. R., Parisi, J. E., Petersen, R. C., Dickson, D. W., Kanekiyo, T. & Bu, G. D., Apr 1 2019, In : Brain : a journal of neurology. 142, 4, p. 1077-1092 16 p.

Research output: Contribution to journalArticle

Tight Junction Proteins
Disease Progression
Alzheimer Disease
Amyloid
Brain
2 Citations (Scopus)

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

Zhong, L., Xu, Y., Zhuo, R., Wang, T., Wang, K., Huang, R., Wang, D., Gao, Y., Zhu, Y., Sheng, X., Chen, K., Wang, N., Zhu, L., Can, D., Marten, Y., Shinohara, M., Liu, C-C., Du, D., Sun, H., Wen, L. & 3 others, Xu, H., Bu, G. D. & Chen, X. F., Dec 1 2019, In : Nature communications. 10, 1, 1365.

Research output: Contribution to journalArticle

Open Access
phenotype
Myeloid Cells
Amyloid
Alzheimer Disease
Amyloid Plaques
2018
1 Citation (Scopus)

AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model

Hettinger, J. C., Lee, H., Bu, G. D., Holtzman, D. M. & Cirrito, J. R., May 15 2018, In : Molecular Neurodegeneration. 13, 1, 22.

Research output: Contribution to journalArticle

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Amyloid
Alzheimer Disease
Extracellular Fluid
AMPA Receptors
17 Citations (Scopus)

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Zhong, L., Wang, Z., Wang, D., Wang, Z., Martens, Y. A., Wu, L., Xu, Y., Wang, K., Li, J., Huang, R., Can, D., Xu, H., Bu, G. D. & Chen, X. F., Mar 27 2018, In : Molecular Neurodegeneration. 13, 1, 15.

Research output: Contribution to journalArticle

Myeloid Cells
Amyloid
Alzheimer Disease
Microglia
Cluster Analysis
11 Citations (Scopus)

APOE ε2 is associated with increased tau pathology in primary tauopathy

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R. V., Murray, M. E., Koga, S. & 3 others, Dickson, D. W., Ross, O. A. & Bu, G. D., Dec 1 2018, In : Nature Communications. 9, 1, 4388.

Research output: Contribution to journalArticle

Apolipoprotein E2
Tauopathies
pathology
Pathology
mice
14 Citations (Scopus)

APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

Dickson, D. W., Heckman, M. G., Murray, M. E., Soto, A. I., Walton, R. L., Diehl, N. N., Van Gerpen, J. A., Uitti, R. J., Wszolek, Z. K., Taner, N., Knopman, D. S., Petersen, R. C., Graff Radford, N. R., Boeve, B. F., Bu, G. D., Ferman, T. J. & Ross, O. A., Sep 18 2018, In : Neurology. 91, 12, p. e1182-e1195

Research output: Contribution to journalArticle

Lewy Bodies
Pathology
Alzheimer Disease
Dementia
Odds Ratio
1 Citation (Scopus)

Association study between multiple system atrophy and TREM2 p.R47H

Ogaki, K., Heckman, M. G., Koga, S., Martens, Y. A., Labbé, C., Lorenzo-Betancor, O., Walton, R. L., Soto, A. I., Vargas, E. R., Fujioka, S., Uitti, R. J., Van Gerpen, J. A., Cheshire, W. P., Younkin, S. G., Wszolek, Z. K., Low, P. A., Singer, W., Bu, G. D., Dickson, D. W. & Ross, O. A., Aug 1 2018, In : Neurology: Genetics. 4, 4, e257.

Research output: Contribution to journalArticle

Multiple System Atrophy
Myeloid Cells
Alzheimer Disease
Odds Ratio
Sample Size
10 Citations (Scopus)

Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

Kang, S., Kurti, A., Baker, K. E., Liu, C-C., Colonna, M., Ulrich, J. D., Holtzman, D. M., Bu, G. D. & Fryer, J. D., Jan 15 2018, In : Human Molecular Genetics. 27, 2, p. 211-223 13 p.

Research output: Contribution to journalArticle

Knockout Mice
Lipopolysaccharides
Myeloid Cells
Neurodegenerative Diseases
Up-Regulation

Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model

Pan, G., Chen, Z., Zheng, H., Zhang, Y., Xu, H., Bu, G. D., Zheng, H. & Li, Y., Jun 29 2018, In : Frontiers in Neural Circuits. 12, 48.

Research output: Contribution to journalArticle

Kainic Acid
Epilepsy
Poisons
Nervous System Diseases
Astrocytes

Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death

Guo, D., Xie, W., Xiong, P., Li, H., Wang, S., Chen, G., Gao, Y., Zhou, J., Zhang, Y., Bu, G. D., Xue, M. & Zhang, J., Oct 1 2018, In : Cell Death and Disease. 9, 10, 951.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 5
Chloride Channels
Oxidative Stress
Phosphorylation
Apoptosis
7 Citations (Scopus)

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation

Leng, L., Zhuang, K., Liu, Z., Huang, C., Gao, Y., Chen, G., Lin, H., Hu, Y., Wu, D., Shi, M., Xie, W., Sun, H., Shao, Z., Li, H., Zhang, K., Mo, W., Huang, T. Y., Xue, M., Yuan, Z., Zhang, X. & 4 others, Bu, G. D., Xu, H., Xu, Q. & Zhang, J., Nov 7 2018, In : Neuron. 100, 3, p. 551-563.e7

Research output: Contribution to journalArticle

Astrocytes
Multiple Endocrine Neoplasia Type 1
Major Depressive Disorder
Depression
Interleukin-1
8 Citations (Scopus)

Modeling neurodegenerative microenvironment using cortical organoids derived from human stem cells

Yan, Y., Song, L., Bejoy, J., Zhao, J., Kanekiyo, T., Bu, G. D., Zhou, Y. & Li, Y., Jul 1 2018, In : Tissue Engineering - Part A. 24, 13-14, p. 1125-1137 13 p.

Research output: Contribution to journalArticle

Organoids
Stem cells
Induced Pluripotent Stem Cells
Alzheimer Disease
Stem Cells
4 Citations (Scopus)

Multiple system atrophy and apolipoprotein E

Ogaki, K., Martens, Y. A., Heckman, M. G., Koga, S., Labbé, C., Lorenzo-Betancor, O., Wernick, A. I., Walton, R. L., Soto, A. I., Vargas, E. R., Nielsen, H. M., Fujioka, S., Kanekiyo, T., Uitti, R. J., Van Gerpen, J. A., Cheshire, W. P., Wszolek, Z. K., Low, P. A., Singer, W., Dickson, D. W. & 2 others, Bu, G. D. & Ross, O. A., Jan 1 2018, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

Multiple System Atrophy
Synucleins
Apolipoproteins E
Oligodendroglia
Protein Isoforms
5 Citations (Scopus)

Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression

Zhuang, K., Huang, C., Leng, L., Zheng, H., Gao, Y., Chen, G., Ji, Z., Sun, H., Hu, Y., Wu, D., Shi, M., Li, H., Zhao, Y., Zhang, Y., Xue, M., Bu, G. D., Huang, T. Y., Xu, H. & Zhang, J., Jul 17 2018, In : Cell Reports. 24, 3, p. 701-712 12 p.

Research output: Contribution to journalArticle

Multiple Endocrine Neoplasia Type 1
Neurons
Dendritic Spines
Neuronal Plasticity
Cognition
5 Citations (Scopus)

Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice

Tachibana, M., Yamazaki, Y., Liu, C-C., Bu, G. D. & Kanekiyo, T., Feb 1 2018, In : Experimental Neurology. 300, p. 13-21 9 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Pericytes
Amyloid
Pathology
Brain
2 Citations (Scopus)

RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease–Associated Cognitive Deficits

Zhao, D., Meng, J., Zhao, Y., Huo, Y., Liu, Y., Zheng, N., Zhang, M., Gao, Y., Chen, Z., Sun, H., Wang, X., Jing, C., Zhang, T., Zhang, X., Luo, H., Wang, X., Zhang, J., Liu, F. R., Li, Y., Bu, G. D. & 4 others, Wen, L., Huang, T. Y., Xu, H. & Zhang, Y. W., Jan 1 2018, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

Alzheimer Disease
Memory Disorders
Knockout Mice
Post-Synaptic Density
Ubiquitination
2 Citations (Scopus)

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease

Dominantly Inherited Alzheimer Network (DIAN), Nov 26 2018, In : Acta neuropathologica communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

Synucleins
Cerebrospinal Fluid
Alzheimer Disease
Mutation
Amyloid
61 Citations (Scopus)

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

Zhao, Y., Wu, X., Li, X., Jiang, L. L., Gui, X., Liu, Y., Sun, Y., Zhu, B., Piña-Crespo, J. C., Zhang, M., Zhang, N., Chen, X., Bu, G. D., An, Z., Huang, T. Y. & Xu, H., Mar 7 2018, In : Neuron. 97, 5, p. 1023-1031.e7

Research output: Contribution to journalArticle

Myeloid Cells
Amyloid
Alzheimer Disease
Ligands
Mutation
2017
46 Citations (Scopus)

ApoE4 Accelerates Early Seeding of Amyloid Pathology

Liu, C-C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C. W. & Bu, G. D., Dec 6 2017, In : Neuron. 96, 5, p. 1024-1032.e3

Research output: Contribution to journalArticle

Apolipoprotein E4
Amyloid
Pathology
Apolipoprotein E3
Apolipoproteins E
28 Citations (Scopus)

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

Zhao, J., Davis, M. D., Martens, Y. A., Shinohara, M., Graff Radford, N. R., Younkin, S. G., Wszolek, Z. K., Kanekiyo, T. & Bu, G. D., Jul 15 2017, In : Human Molecular Genetics. 26, 14, p. 2690-2700 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Astrocytes
Apolipoproteins E
Genotype
Protein Isoforms
56 Citations (Scopus)

Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease

Zhao, N., Liu, C-C., Qiao, W. & Bu, G. D., Feb 1 2017, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Apolipoproteins E
Alzheimer Disease
Lipids
Amyloid
46 Citations (Scopus)

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Martens, Y. A., Linares, C., Knight, J. A., Painter, M. M., Sullivan, P. M. & Bu, G. D., Sep 27 2017, In : Neuron. 96, 1, p. 115-129 15 p.

Research output: Contribution to journalArticle

Apolipoprotein E4
Endosomes
Insulin Receptor
Insulin
Alzheimer Disease
34 Citations (Scopus)

Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition

Liu, C-C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M. & Bu, G. D., Apr 12 2017, In : Journal of Neuroscience. 37, 15, p. 4023-4031 9 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Amyloid
Astrocytes
Alzheimer Disease
Brain
4 Citations (Scopus)

Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β42 in Alzheimer's disease

Shinohara, M., Koga, S., Konno, T., Nix, J., Shinohara, M., Aoki, N., Das, P., Parisi, J. E., Petersen, R. C., Rosenberry, T. L., Dickson, D. W. & Bu, G. D., Dec 1 2017, In : Brain. 140, 12, p. 3301-3316 16 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Apolipoproteins E
Immunosorbents
Brain
3 Citations (Scopus)

Intracellular trafficking of TREM2 is regulated by presenilin 1

Zhao, Y., Li, X., Huang, T., Jiang, L. L., Tan, Z., Zhang, M., Cheng, I. H. J., Wang, X., Bu, G. D., Zhang, Y. W., Wang, Q. & Xu, H., Jan 1 2017, In : Experimental and Molecular Medicine. 49, 12, e405.

Research output: Contribution to journalArticle

Presenilin-1
Myeloid Cells
Amyloid Precursor Protein Secretases
Microglia
Mutation
19 Citations (Scopus)

Lipocalin-2 protects the brain during inflammatory conditions

Kang, S., Ren, Y., Liu, C-C., Kurti, A., Baker, K. E., Bu, G. D., Asmann, Y. & Fryer, J. D., Jan 10 2017, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Lipopolysaccharides
Central Nervous System
Brain
Cytokines
Sepsis
22 Citations (Scopus)

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Wojtas, A. M., Kang, S., Olley, B. M., Gatherer, M., Shinohara, M., Lozano, P. A., Liu, C-C., Kurti, A., Baker, K. E., Dickson, D. W., Yue, M., Petrucelli, L., Bu, G. D., Carare, R. O. & Fryer, J. D., Aug 15 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 33, p. E6962-E6971

Research output: Contribution to journalArticle

Clusterin
Cerebral Amyloid Angiopathy
Amyloid
Drainage
Alzheimer Disease
32 Citations (Scopus)

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy

Yuan, H., Jiang, W., von Roemeling, C. A., Qie, Y., Liu, X., Chen, Y., Wang, Y., Wharen, R. E., Yun, K., Bu, G. D., Knutson, K. L. & Kim, Y. S. B., May 1 2017, (Accepted/In press) In : Nature Nanotechnology.

Research output: Contribution to journalArticle

Tumors
cancer
Cells
tumors
Calreticulin
6 Citations (Scopus)

Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

Nielsen, H. M., Chen, K., Lee, W., Chen, Y., Bauer, R. J., Reiman, E., Caselli, R. J. & Bu, G. D., Jan 30 2017, In : Alzheimer's Research and Therapy. 9, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Protein Isoforms
Glucose
Apolipoprotein E4
Apolipoprotein E3
11 Citations (Scopus)

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients

Valdez, C., Wong, Y. C., Schwake, M., Bu, G. D., Wszolek, Z. K. & Krainc, D., Dec 1 2017, In : Human Molecular Genetics. 26, 24, p. 4861-4872 12 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Frontotemporal Dementia
Cathepsin D
Phenotype
Neurons
49 Citations (Scopus)

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C-C., Zhang, Y. W., Fryer, J. D., Xu, H. & Bu, G. D., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 597-607 11 p.

Research output: Contribution to journalArticle

Microglia
Myeloid Cells
Cytokines
Cell Surface Receptors
Phosphatidylinositol 3-Kinases
8 Citations (Scopus)

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

Rogers, J. T., Liu, C-C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T. & Bu, G. D., May 1 2017, In : Neurobiology of Aging. 53, p. 112-121 10 p.

Research output: Contribution to journalArticle

Ibuprofen
Cognition
Neuronal Plasticity
Astrocytes
Anti-Inflammatory Agents
2 Citations (Scopus)

Synaptic adhesion molecule Pcdh-γC5 mediates synaptic dysfunction in Alzheimer’s disease

Li, Y., Chen, Z., Gao, Y., Pan, G., Zheng, H., Zhang, Y., Xu, H., Bu, G. D. & Zheng, H., Sep 20 2017, In : Journal of Neuroscience. 37, 38, p. 9259-9268 10 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Presenilin-1
Amyloid beta-Protein Precursor
Cadherins
Amyloid
11 Citations (Scopus)

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Ando, M., Fiesel, F., Hudec, R., Caulfield, T., Ogaki, K., Górka-Skoczylas, P., Koziorowski, D., Friedman, A., Chen, L., Dawson, V. L., Dawson, T. M., Bu, G. D., Ross, O. A., Wszolek, Z. K. & Springer, W., Apr 24 2017, In : Molecular Neurodegeneration. 12, 1, 32.

Research output: Contribution to journalArticle

Protein Stability
Ubiquitin
Phosphotransferases
Mutation
Mitochondrial Membranes
11 Citations (Scopus)

TREM2/DAP12 complex regulates inflammatory responses in Microglia via the JNK signaling pathway

Zhong, L., Zhang, Z. L., Li, X., Liao, C., Mou, P., Wang, T., Wang, Z., Wang, Z., Wei, M., Xu, H., Bu, G. D. & Chen, X. F., Jun 21 2017, In : Frontiers in Aging Neuroscience. 9, JUN, 204.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Microglia
Proteins
Mutation
Myeloid Cells
45 Citations (Scopus)

TREM2 promotes microglial survival by activating wnt/β-catenin pathway

Zheng, H., Jia, L., Liu, C-C., Rong, Z., Zhong, L., Yang, L., Chen, X. F., Fryer, J. D., Wang, X., Zhang, Y. W., Xu, H. & Bu, G. D., Feb 15 2017, In : Journal of Neuroscience. 37, 7, p. 1772-1784 13 p.

Research output: Contribution to journalArticle

Catenins
Wnt Signaling Pathway
Myeloid Cells
Microglia
Alzheimer Disease
2016
40 Citations (Scopus)

ABCA7 deficiency accelerates amyloid-βgeneration and alzheimer’s neuronal pathology

Sakae, N., Liu, C-C., Shinohara, M., Frisch-Daiello, J., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L., Kurti, A., Carrasquillo, M. M., Zou, F., Sevlever, D., Bisceglio, G., Gan, M., Fol, R., Knight, P., Wang, M., Han, X., Fryer, J. D., Fitzgerald, M. L. & 4 others, Ohyagi, Y., Younkin, S. G., Bu, G. D. & Kanekiyo, T., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid
Pathology
Alzheimer Disease
Brain
27 Citations (Scopus)

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch-Daiello, J. L., Han, X., Fryer, J. D. & Bu, G. D., 2016, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

Apolipoproteins E
Apolipoprotein E2
Cholesterol
Amyloid
Alleles
23 Citations (Scopus)

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Yamazaki, Y., Painter, M. M., Bu, G. D. & Kanekiyo, T., Jun 21 2016, (Accepted/In press) In : CNS Drugs. p. 1-17 17 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Alzheimer Disease
Research
Therapeutics
Biological Phenomena
7 Citations (Scopus)

Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population

Kang, R., Li, P., Wang, T., Li, X., Wei, Z., Zhang, Z., Zhong, L., Cao, L., Heckman, M. G., Zhang, Y. W., Xu, H., Huang, C., Bu, G. D. & Chen, X. F., Jan 28 2016, In : Scientific Reports. 6, 19930.

Research output: Contribution to journalArticle

Apolipoprotein E2
Stomach Neoplasms
Alleles
Cholesterol
Serum
19 Citations (Scopus)

Apolipoprotein e lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

Fu, Y., Zhao, J., Atagi, Y., Nielsen, H. M., Liu, C-C., Zheng, H., Shinohara, M., Kanekiyo, T. & Bu, G. D., May 5 2016, In : Molecular Neurodegeneration. 11, 1, 99.

Research output: Contribution to journalArticle

Heparan Sulfate Proteoglycans
Apolipoproteins
Apolipoproteins E
Amyloid
Lipoproteins
11 Citations (Scopus)

Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology

Zhang, C., Shi, Z., Zhang, L., Zhou, Z., Zheng, X., Liu, G., Bu, G. D., Fraser, P. E., Xu, H. & Zhang, Y. W., 2016, In : Journal of Cell Science. 129, 5, p. 994-1002 9 p.

Research output: Contribution to journalArticle

Membrane Fusion Proteins
Membrane Fusion
Apoptosis
Reactive Oxygen Species
Alzheimer Disease
13 Citations (Scopus)

A rapid and cost-effective method for genotyping apolipoprotein e gene polymorphism

Zhong, L., Xie, Y. Z., Cao, T. T., Wang, Z., Wang, T., Li, X., Shen, R. C., Xu, H., Bu, G. D. & Chen, X. F., Jan 12 2016, In : Molecular Neurodegeneration. 11, 1, 2.

Research output: Contribution to journalArticle

Apolipoproteins
Alleles
Apolipoproteins E
Vascular Diseases
Costs and Cost Analysis
96 Citations (Scopus)

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Zhang, Y., Gendron, T. D., Grima, J. C., Sasaguri, H., Jansen-West, K., Xu, Y. F., Katzman, R. B., Gass, J., Murray, M. E., Shinohara, M., Lin, W. L., Garrett, A., Stankowski, J. N., Daughrity, L., Tong, J., Perkerson, E. A., Yue, M., Chew, J., Castanedes-Casey, M., Kurti, A. & 16 others, Wang, Z. S., Liesinger, A. M., Baker, J. D., Jiang, J., Lagier-Tourenne, C., Edbauer, D., Cleveland, D. W., Rademakers, R. V., Boylan, K. B., Bu, G. D., Link, C. D., Dickey, C. A., Rothstein, J. D., Dickson, D. W., Fryer, J. D. & Petrucelli, L., May 1 2016, In : Nature Neuroscience. 19, 5, p. 668-677 10 p.

Research output: Contribution to journalArticle

Nucleocytoplasmic Transport Proteins
Cell Nucleus Active Transport
Pathology
Ubiquitinated Proteins
Xeroderma Pigmentosum
12 Citations (Scopus)

Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

Reynolds, M. R., Singh, I., Azad, T. D., Holmes, B. B., Verghese, P. B., Dietrich, H. H., Diamond, M., Bu, G. D., Han, B. H. & Zipfel, G. J., Jan 22 2016, In : Molecular Neurodegeneration. 11, 1, 9.

Research output: Contribution to journalArticle

Heparan Sulfate Proteoglycans
Vascular Smooth Muscle
Smooth Muscle Myocytes
Oxidative Stress
Pharmacology
22 Citations (Scopus)

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., Deture, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C-C., Zhao, N., Painter, M. M., Petersen, R. C., Fryer, J. D., Crook, J., Dickson, D. W., Bu, G. D. & Kanekiyo, T., May 14 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-10 10 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Alzheimer Disease
Apolipoproteins E
Temporal Lobe
Amyloid
50 Citations (Scopus)

Implications of GABAergic neurotransmission in Alzheimer's disease

Li, Y., Sun, H., Chen, Z., Xu, H., Bu, G. D. & Zheng, H., 2016, In : Frontiers in Aging Neuroscience. 8, FEB, 31.

Research output: Contribution to journalArticle

Synaptic Transmission
Alzheimer Disease
Apolipoprotein E4
Neurofibrillary Tangles
Amyloid