• 18226 Citations
  • 75 Scopus h-Index
1985 …2020

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Article
2020

Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

Zhao, N., Ren, Y., Yamazaki, Y., Qiao, W., Li, F., Felton, L. M., Mahmoudiandehkordi, S., Kueider-Paisley, A., Sonoustoun, B., Arnold, M., Shue, F., Zheng, J., Attrebi, O. N., Martens, Y. A., Li, Z., Bastea, L., Meneses, A. D., Chen, K., Thompson, J. W., St John-Williams, L. & 12 others, Tachibana, M., Aikawa, T., Oue, H., Job, L., Yamazaki, A., Liu, C. C., Storz, P., Asmann, Y. W., Ertekin-Taner, N., Kanekiyo, T., Kaddurah-Daouk, R. & Bu, G., Jan 1 2020, (Accepted/In press) In : Neuron.

Research output: Contribution to journalArticle

1 Scopus citations

APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

Zhao, N., Attrebi, O. N., Ren, Y., Qiao, W., Sonustun, B., Martens, Y. A., Meneses, A. D., Li, F., Shue, F., Zheng, J., van Ingelgom, A. J., Davis, M. D., Kurti, A., Knight, J. A., Linares, C., Chen, Y., Delenclos, M., Liu, C. C., Fryer, J. D., Asmann, Y. W. & 4 others, McLean, P. J., Dickson, D. W., Ross, O. A. & Bu, G., Feb 5 2020, In : Science translational medicine. 12, 529, eaay1809.

Research output: Contribution to journalArticle

7 Scopus citations

Cyclin-Dependent Kinase 5–Dependent BAG3 Degradation Modulates Synaptic Protein Turnover

Zhou, J., Chow, H. M., Liu, Y., Wu, D., Shi, M., Li, J., Wen, L., Gao, Y., Chen, G., Zhuang, K., Lin, H., Zhang, G., Xie, W., Li, H., Leng, L., Wang, M., Zheng, N., Sun, H., Zhao, Y., Zhang, Y. & 7 others, Xue, M., Huang, T. Y., Bu, G., Xu, H., Yuan, Z., Herrup, K. & Zhang, J., Apr 15 2020, In : Biological psychiatry. 87, 8, p. 756-769 14 p.

Research output: Contribution to journalArticle

Open Access

Interaction between APOE genotype and diabetes in cognitive decline

Shinohara, M., Tashiro, Y., Suzuki, K., Fukumori, A., Bu, G. & Sato, N., Jan 1 2020, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 12, 1, e12006.

Research output: Contribution to journalArticle

Open Access
2019

5-HT3 antagonist ondansetron increases apoE secretion by modulating the LXR-ABCA1 pathway

Shinohara, M., Shinohara, M., Zhao, J., Fu, Y., Liu, C-C., Kanekiyo, T. & Bu, G. D., Mar 2 2019, In : International Journal of Molecular Sciences. 20, 6, 1488.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

Aikawa, T., Ren, Y., Yamazaki, Y., Tachibana, M., Johnson, M. R., Anderson, C. T., Martens, Y. A., Holm, M. L., Asmann, Y. W., Saito, T., Saido, T. C., Fitzgerald, M. L., Bu, G. & Kanekiyo, T., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 47, p. 23790-23796 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II

Zhao, S., Li, Z., Zhang, M., Zhang, L., Zheng, H., Ning, J., Wang, Y., Wang, F., Zhang, X., Gan, H., Wang, Y., Zhang, X., Luo, H., Bu, G., Xu, H., Yao, Y. & Zhang, Y. W., Jul 1 2019, In : Experimental and Molecular Medicine. 51, 7, 84.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

Tachibana, M., Holm, M. L., Liu, C-C., Shinohara, M., Aikawa, T., Oue, H., Yamazaki, Y., Martens, Y. A., Murray, M. E., Sullivan, P. M., Weyer, K., Glerup, S., Dickson, D. W., Bu, G. D. & Kanekiyo, T., Mar 1 2019, In : Journal of Clinical Investigation. 129, 3, p. 1272-1277 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Differential Effects of Extracellular Vesicles of Lineage-Specific Human Pluripotent Stem Cells on the Cellular Behaviors of Isogenic Cortical Spheroids

Marzano, M., Bejoy, J., Cheerathodi, M. R., Sun, L., York, S. B., Zhao, J., Kanekiyo, T., Bu, G., Meckes, D. G. & Li, Y., Aug 28 2019, In : Cells. 8, 9

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models

Hsieh, C. H., Li, L., Vanhauwaert, R., Nguyen, K. T., Davis, M. D., Bu, G., Wszolek, Z. K. & Wang, X., Dec 3 2019, In : Cell Metabolism. 30, 6, p. 1131-1140.e7

Research output: Contribution to journalArticle

4 Scopus citations

RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease–Associated Cognitive Deficits

Zhao, D., Meng, J., Zhao, Y., Huo, Y., Liu, Y., Zheng, N., Zhang, M., Gao, Y., Chen, Z., Sun, H., Wang, X., Jing, C., Zhang, T., Zhang, X., Luo, H., Wang, X., Zhang, J., Liu, F. R., Li, Y., Bu, G. & 4 others, Wen, L., Huang, T. Y., Xu, H. & Zhang, Y. W., Aug 1 2019, In : Biological psychiatry. 86, 3, p. 171-184 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression

Yamazaki, Y., Shinohara, M., Shinohara, M., Yamazaki, A., Murray, M. E., Liesinger, A. M., Heckman, M. G., Lesser, E. R., Parisi, J. E., Petersen, R. C., Dickson, D. W., Kanekiyo, T. & Bu, G., Jan 1 2019, In : Brain. 142, 4, p. 1077-1092 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

Zhong, L., Xu, Y., Zhuo, R., Wang, T., Wang, K., Huang, R., Wang, D., Gao, Y., Zhu, Y., Sheng, X., Chen, K., Wang, N., Zhu, L., Can, D., Marten, Y., Shinohara, M., Liu, C. C., Du, D., Sun, H., Wen, L. & 3 others, Xu, H., Bu, G. & Chen, X. F., Dec 1 2019, In : Nature communications. 10, 1, 1365.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
2018

AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model

Hettinger, J. C., Lee, H., Bu, G., Holtzman, D. M. & Cirrito, J. R., May 15 2018, In : Molecular neurodegeneration. 13, 1, 22.

Research output: Contribution to journalArticle

4 Scopus citations

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Zhong, L., Wang, Z., Wang, D., Wang, Z., Martens, Y. A., Wu, L., Xu, Y., Wang, K., Li, J., Huang, R., Can, D., Xu, H., Bu, G. & Chen, X. F., Mar 27 2018, In : Molecular neurodegeneration. 13, 1, 15.

Research output: Contribution to journalArticle

28 Scopus citations

APOE ε2 is associated with increased tau pathology in primary tauopathy

Zhao, N., Liu, C. C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff-Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R., Murray, M. E., Koga, S. & 3 others, Dickson, D. W., Ross, O. A. & Bu, G., Dec 1 2018, In : Nature communications. 9, 1, 4388.

Research output: Contribution to journalArticle

22 Scopus citations

APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

Dickson, D. W., Heckman, M. G., Murray, M. E., Soto, A. I., Walton, R. L., Diehl, N. N., Van Gerpen, J. A., Uitti, R. J., Wszolek, Z. K., Ertekin-Taner, N., Knopman, D. S., Petersen, R. C., Graff-Radford, N. R., Boeve, B. F., Bu, G., Ferman, T. J. & Ross, O. A., Sep 18 2018, In : Neurology. 91, 12, p. e1182-e1195

Research output: Contribution to journalArticle

24 Scopus citations

Association study between multiple system atrophy and TREM2 p.R47H

Ogaki, K., Heckman, M. G., Koga, S., Martens, Y. A., Labbé, C., Lorenzo-Betancor, O., Walton, R. L., Soto, A. I., Vargas, E. R., Fujioka, S., Uitti, R. J., Van Gerpen, J. A., Cheshire, W. P. J., Younkin, S. G., Wszolek, Z. K., Low, P. A., Singer, W., Bu, G., Dickson, D. W. & Ross, O. A., Aug 1 2018, In : Neurology: Genetics. 4, 4, e257.

Research output: Contribution to journalArticle

2 Scopus citations

Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

Kang, S., Kurti, A., Baker, K. E., Liu, C-C., Colonna, M., Ulrich, J. D., Holtzman, D. M., Bu, G. D. & Fryer, J. D., Jan 15 2018, In : Human Molecular Genetics. 27, 2, p. 211-223 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model

Pan, G., Chen, Z., Zheng, H., Zhang, Y., Xu, H., Bu, G., Zheng, H. & Li, Y., Jun 29 2018, In : Frontiers in Neural Circuits. 12, 48.

Research output: Contribution to journalArticle

Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death

Guo, D., Xie, W., Xiong, P., Li, H., Wang, S., Chen, G., Gao, Y., Zhou, J., Zhang, Y., Bu, G., Xue, M. & Zhang, J., Oct 1 2018, In : Cell Death and Disease. 9, 10, 951.

Research output: Contribution to journalArticle

7 Scopus citations

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation

Leng, L., Zhuang, K., Liu, Z., Huang, C., Gao, Y., Chen, G., Lin, H., Hu, Y., Wu, D., Shi, M., Xie, W., Sun, H., Shao, Z., Li, H., Zhang, K., Mo, W., Huang, T. Y., Xue, M., Yuan, Z., Zhang, X. & 4 others, Bu, G., Xu, H., Xu, Q. & Zhang, J., Nov 7 2018, In : Neuron. 100, 3, p. 551-563.e7

Research output: Contribution to journalArticle

17 Scopus citations

Modeling neurodegenerative microenvironment using cortical organoids derived from human stem cells

Yan, Y., Song, L., Bejoy, J., Zhao, J., Kanekiyo, T., Bu, G. D., Zhou, Y. & Li, Y., Jul 1 2018, In : Tissue Engineering - Part A. 24, 13-14, p. 1125-1137 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Multiple system atrophy and apolipoprotein E

Ogaki, K., Martens, Y. A., Heckman, M. G., Koga, S., Labbé, C., Lorenzo-Betancor, O., Wernick, A. I., Walton, R. L., Soto, A. I., Vargas, E. R., Nielsen, H. M., Fujioka, S., Kanekiyo, T., Uitti, R. J., van Gerpen, J. A., Cheshire, W. P., Wszolek, Z. K., Low, P. A., Singer, W., Dickson, D. W. & 2 others, Bu, G. & Ross, O. A., Apr 2018, In : Movement Disorders. 33, 4, p. 647-650 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression

Zhuang, K., Huang, C., Leng, L., Zheng, H., Gao, Y., Chen, G., Ji, Z., Sun, H., Hu, Y., Wu, D., Shi, M., Li, H., Zhao, Y., Zhang, Y., Xue, M., Bu, G., Huang, T. Y., Xu, H. & Zhang, J., Jul 17 2018, In : Cell reports. 24, 3, p. 701-712 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice

Tachibana, M., Yamazaki, Y., Liu, C-C., Bu, G. D. & Kanekiyo, T., Feb 1 2018, In : Experimental Neurology. 300, p. 13-21 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease

Dominantly Inherited Alzheimer Network (DIAN), Nov 26 2018, In : Acta Neuropathologica Communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

6 Scopus citations

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

Zhao, Y., Wu, X., Li, X., Jiang, L. L., Gui, X., Liu, Y., Sun, Y., Zhu, B., Piña-Crespo, J. C., Zhang, M., Zhang, N., Chen, X., Bu, G. D., An, Z., Huang, T. Y. & Xu, H., Mar 7 2018, In : Neuron. 97, 5, p. 1023-1031.e7

Research output: Contribution to journalArticle

103 Scopus citations
2017

ApoE4 Accelerates Early Seeding of Amyloid Pathology

Liu, C-C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C. W. & Bu, G. D., Dec 6 2017, In : Neuron. 96, 5, p. 1024-1032.e3

Research output: Contribution to journalArticle

68 Scopus citations

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

Zhao, J., Davis, M. D., Martens, Y. A., Shinohara, M., Graff Radford, N. R., Younkin, S. G., Wszolek, Z. K., Kanekiyo, T. & Bu, G. D., Jul 15 2017, In : Human Molecular Genetics. 26, 14, p. 2690-2700 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease

Zhao, N., Liu, C-C., Qiao, W. & Bu, G. D., Feb 1 2017, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

83 Scopus citations

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Martens, Y. A., Linares, C., Knight, J. A., Painter, M. M., Sullivan, P. M. & Bu, G. D., Sep 27 2017, In : Neuron. 96, 1, p. 115-129 15 p.

Research output: Contribution to journalArticle

69 Scopus citations

Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition

Liu, C. C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M. & Bu, G., Apr 12 2017, In : Journal of Neuroscience. 37, 15, p. 4023-4031 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β42 in Alzheimer's disease

Shinohara, M., Koga, S., Konno, T., Nix, J., Shinohara, M., Aoki, N., Das, P., Parisi, J. E., Petersen, R. C., Rosenberry, T. L., Dickson, D. W. & Bu, G. D., Dec 1 2017, In : Brain. 140, 12, p. 3301-3316 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Intracellular trafficking of TREM2 is regulated by presenilin 1

Zhao, Y., Li, X., Huang, T., Jiang, L. L., Tan, Z., Zhang, M., Cheng, I. H. J., Wang, X., Bu, G. D., Zhang, Y. W., Wang, Q. & Xu, H., Jan 1 2017, In : Experimental and Molecular Medicine. 49, 12, e405.

Research output: Contribution to journalArticle

4 Scopus citations

Lipocalin-2 protects the brain during inflammatory conditions

Kang, S., Ren, Y., Liu, C-C., Kurti, A., Baker, K. E., Bu, G. D., Asmann, Y. & Fryer, J. D., Jan 10 2017, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

30 Scopus citations

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Wojtas, A. M., Kang, S., Olley, B. M., Gatherer, M., Shinohara, M., Lozano, P. A., Liu, C-C., Kurti, A., Baker, K. E., Dickson, D. W., Yue, M., Petrucelli, L., Bu, G. D., Carare, R. O. & Fryer, J. D., Aug 15 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 33, p. E6962-E6971

Research output: Contribution to journalArticle

32 Scopus citations

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy

Yuan, H., Jiang, W., von Roemeling, C. A., Qie, Y., Liu, X., Chen, Y., Wang, Y., Wharen, R. E., Yun, K., Bu, G. D., Knutson, K. L. & Kim, Y. S. B., May 1 2017, (Accepted/In press) In : Nature Nanotechnology.

Research output: Contribution to journalArticle

49 Scopus citations

Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

Nielsen, H. M., Chen, K., Lee, W., Chen, Y., Bauer, R. J., Reiman, E., Caselli, R. & Bu, G., Jan 30 2017, In : Alzheimer's Research and Therapy. 9, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients

Valdez, C., Wong, Y. C., Schwake, M., Bu, G. D., Wszolek, Z. K. & Krainc, D., Dec 1 2017, In : Human Molecular Genetics. 26, 24, p. 4861-4872 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C. C., Zhang, Y. W., Fryer, J. D., Xu, H. & Bu, G., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 597-607 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

Rogers, J. T., Liu, C-C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T. & Bu, G. D., May 1 2017, In : Neurobiology of Aging. 53, p. 112-121 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Synaptic adhesion molecule Pcdh-γC5 mediates synaptic dysfunction in Alzheimer’s disease

Li, Y., Chen, Z., Gao, Y., Pan, G., Zheng, H., Zhang, Y., Xu, H., Bu, G. D. & Zheng, H., Sep 20 2017, In : Journal of Neuroscience. 37, 38, p. 9259-9268 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Ando, M., Fiesel, F. C., Hudec, R., Caulfield, T. R., Ogaki, K., Górka-Skoczylas, P., Koziorowski, D., Friedman, A., Chen, L., Dawson, V. L., Dawson, T. M., Bu, G., Ross, O. A., Wszolek, Z. K. & Springer, W., Apr 24 2017, In : Molecular neurodegeneration. 12, 1, 32.

Research output: Contribution to journalArticle

16 Scopus citations

TREM2/DAP12 complex regulates inflammatory responses in Microglia via the JNK signaling pathway

Zhong, L., Zhang, Z. L., Li, X., Liao, C., Mou, P., Wang, T., Wang, Z., Wang, Z., Wei, M., Xu, H., Bu, G. D. & Chen, X. F., Jun 21 2017, In : Frontiers in Aging Neuroscience. 9, JUN, 204.

Research output: Contribution to journalArticle

18 Scopus citations

TREM2 promotes microglial survival by activating wnt/β-catenin pathway

Zheng, H., Jia, L., Liu, C-C., Rong, Z., Zhong, L., Yang, L., Chen, X. F., Fryer, J. D., Wang, X., Zhang, Y. W., Xu, H. & Bu, G. D., Feb 15 2017, In : Journal of Neuroscience. 37, 7, p. 1772-1784 13 p.

Research output: Contribution to journalArticle

68 Scopus citations
2016

ABCA7 deficiency accelerates amyloid-βgeneration and alzheimer’s neuronal pathology

Sakae, N., Liu, C. C., Shinohara, M., Frisch-Daiello, J., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L., Kurti, A., Carrasquillo, M. M., Zou, F., Sevlever, D., Bisceglio, G., Gan, M., Fol, R., Knight, P., Wang, M., Han, X., Fryer, J. D., Fitzgerald, M. L. & 4 others, Ohyagi, Y., Younkin, S. G., Bu, G. & Kanekiyo, T., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch-Daiello, J. L., Han, X., Fryer, J. D. & Bu, G. D., 2016, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

35 Scopus citations

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Yamazaki, Y., Painter, M. M., Bu, G. D. & Kanekiyo, T., Jun 21 2016, (Accepted/In press) In : CNS Drugs. p. 1-17 17 p.

Research output: Contribution to journalArticle

33 Scopus citations