Clifford R Jr. Jack, MD

  • 84694 Citations
  • 140 Scopus h-Index
1984 …2020

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2020

Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease

Dominantly Inherited Alzheimer Network (DIAN) & PREVENT-AD Research Group, 2020, (Accepted/In press) In : Biological psychiatry.

Research output: Contribution to journalArticle

1 Scopus citations

Aortic Stiffness and White Matter Microstructural Integrity Assessed by Diffusion Tensor Imaging: The ARIC-NCS

Wei, J., Palta, P., Meyer, M. L., Kucharska-Newton, A., Pence, B. W., Aiello, A. E., Power, M. C., Walker, K. A., Sharrett, A. R., Tanaka, H., Jack, C. R., Mosley, T. H., Reid, R. I., Reyes, D. A. & Heiss, G., Mar 17 2020, In : Journal of the American Heart Association. 9, 6, p. e014868

Research output: Contribution to journalArticle

Open Access

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

The Dominantly Inherited Alzheimer Network, Mar 1 2020, In : Nature Medicine. 26, 3, p. 398-407 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Better stress coping associated with lower tau in amyloid-positive cognitively unimpaired older adults

Arenaza-Urquijo, E. M., Przybelski, S. A., MacHulda, M. M., Knopman, D. S., Lowe, V. J., Mielke, M. M., Reddy, A. L., Geda, Y. E., Jack, C. R., Petersen, R. C. & Vemuri, P., Apr 14 2020, In : Neurology. 94, 15, p. E1571-E1579

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Brain amyloid, cortical thickness, and changes in activities of daily living

Vassilaki, M., Aakre, J. A., Kremers, W. K., Lesnick, T. G., Mielke, M. M., Geda, Y. E., Machulda, M. M., Knopman, D. S., Butler, L., Traber, M., Vemuri, P., Lowe, V. J., Jack, C. R., Roberts, R. O. & Petersen, R. C., Jan 1 2020, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

Open Access

Brain imaging measurements of fibrillar amyloid-β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele

Ghisays, V., Goradia, D. D., Protas, H., Bauer, R. J., Devadas, V., Tariot, P. N., Lowe, V. J., Knopman, D. S., Petersen, R. C., Jack, C. R., Caselli, R. J., Su, Y., Chen, K. & Reiman, E. M., Apr 1 2020, In : Alzheimer's and Dementia. 16, 4, p. 598-609 12 p.

Research output: Contribution to journalArticle

Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants

Whitwell, J. L., Tosakulwong, N., Botha, H., Ali, F., Clark, H. M., Duffy, J. R., Utianski, R. L., Stevens, C. A., Weigand, S. D., Schwarz, C. G., Senjem, M. L., Jack, C. R., Lowe, V. J., Ahlskog, J. E., Dickson, D. W. & Josephs, K. A., 2020, In : NeuroImage: Clinical. 25, 102152.

Research output: Contribution to journalArticle

Open Access

Cerebral microbleed incidence, relationship to amyloid burden: The Mayo Clinic Study of Aging

Graff-Radford, J., Lesnick, T., Rabinstein, A. A., Gunter, J., Aakre, J., Przybelski, S. A., Spychalla, A. J., Huston, J., Brown, R. D., Mielke, M. M., Lowe, V. J., Knopman, D. S., Petersen, R. C., Jack, C. R., Vemuri, P., Kremers, W. & Kantarci, K., Jan 14 2020, In : Neurology. 94, 2, p. e190-e199

Research output: Contribution to journalArticle

Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

The Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2020, In : Scientific reports. 10, 1, 2975.

Research output: Contribution to journalArticle

Open Access

Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging

Machulda, M. M., Lundt, E. S., Albertson, S. M., Spychalla, A. J., Schwarz, C. G., Mielke, M. M., Jack, C. R., Kremers, W. K., Vemuri, P., Knopman, D. S., Jones, D. T., Bondi, M. W. & Petersen, R. C., 2020, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Open Access

Effect Modifiers of TDP-43-Associated Hippocampal Atrophy Rates in Patients with Alzheimer's Disease Neuropathological Changes

Buciuc, M., Wennberg, A. M., Weigand, S. D., Murray, M. E., Senjem, M. L., Spychalla, A. J., Boeve, B. F., Knopman, D. S., Jack, C. R., Kantarci, K., Parisi, J. E., Dickson, D. W., Petersen, R. C., Whitwell, J. L. & Josephs, K. A., Jan 1 2020, In : Journal of Alzheimer's Disease. 73, 4, p. 1511-1523 13 p.

Research output: Contribution to journalArticle

Exposure to surgery with general anaesthesia during adult life is not associated with increased brain amyloid deposition in older adults

Sprung, J., Warner, D. O., Knopman, D. S., Petersen, R. C., Mielke, M. M., Jack, C. R., Lowe, V. J., Martin, D. P., Hanson, A. C., Schroeder, D. R., Przybelski, S. A., Schulte, P. J., Weingarten, T. N. & Vemuri, P., May 2020, In : British journal of anaesthesia. 124, 5, p. 594-602 9 p.

Research output: Contribution to journalArticle

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

The Alzheimer Disease Neuroimaging Initiative, Dec 1 2020, In : Nature communications. 11, 1, 411.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2020, In : Nature communications. 11, 1, 347.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis

Zeydan, B., Lowe, V. J., Reichard, R. R., Przybelski, S. A., Lesnick, T. G., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Parisi, J. E., Machulda, M. M., Vemuri, P., Mielke, M. M., Knopman, D. S., Petersen, R. C., Jack, C. R., Kantarci, O. H. & Kantarci, K., Apr 1 2020, In : Annals of neurology. 87, 4, p. 556-567 12 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Longitudinal amyloid-β PET in atypical Alzheimer's disease and frontotemporal lobar degeneration

Whitwell, J. L., Tosakulwong, N., Weigand, S. D., Graff-Radford, J., Duffy, J. R., Clark, H. M., Machulda, M. M., Botha, H., Utianski, R. L., Schwarz, C. G., Senjem, M. L., Strand, E., Ertekin-Taner, N., Jack, C. R., Lowe, V. J. & Josephs, K. A., Jan 1 2020, In : Journal of Alzheimer's Disease. 74, 1, p. 377-389 13 p.

Research output: Contribution to journalArticle

Longitudinal flortaucipir ([18F]AV-1451) PET uptake in semantic dementia

Utianski, R. L., Botha, H., Whitwell, J. L., Martin, P. R., Schwarz, C. G., Duffy, J. R., Clark, H. M., Spychalla, A. J., Senjem, M. L., Petersen, R. C., Knopman, D. S., Jack, C. R., Lowe, V. J. & Josephs, K. A., Aug 2020, In : Neurobiology of aging. 92, p. 135-140 6 p.

Research output: Contribution to journalArticle

Open Access

Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia

Petroi, D., Duffy, J. R., Borgert, A., Strand, E. A., Machulda, M. M., Senjem, M. L., Jack, C. R., Josephs, K. A. & Whitwell, J. L., May 2020, In : Brain and Language. 204, 104773.

Research output: Contribution to journalArticle

Prevalence and Heterogeneity of Cerebrovascular Disease Imaging Lesions

Graff-Radford, J., Aakre, J. A., Knopman, D. S., Schwarz, C. G., Flemming, K. D., Rabinstein, A. A., Gunter, J. L., Ward, C. P., Zuk, S. M., Spychalla, A. J., Preboske, G. M., Petersen, R. C., Kantarci, K., Huston, J., Jack, C. R., Mielke, M. M. & Vemuri, P., Jun 2020, In : Mayo Clinic proceedings. 95, 6, p. 1195-1205 11 p.

Research output: Contribution to journalArticle

The genetic architecture of the human cerebral cortex

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group, Mar 20 2020, In : Science. 367, 6484, aay6690.

Research output: Contribution to journalArticle

23 Scopus citations

Trajectory of lobar atrophy in asymptomatic and symptomatic GRN mutation carriers: a longitudinal MRI study

Chen, Q., Boeve, B. F., Senjem, M., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J., Forsberg, L., Gavrilova, R., Gearhart, D., Graff-Radford, J., Graff-Radford, N., Jack, C. R., Jones, D., Knopman, D., Kremers, W. K., Lapid, M., Rademakers, R., Ramos, E. M. & 5 others, Syrjanen, J., Boxer, A. L., Rosen, H., Wszolek, Z. K. & Kantarci, K., Apr 2020, In : Neurobiology of aging. 88, p. 42-50 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

β-Amyloid PET and neuropathology in dementia with Lewy bodies

Kantarci, K., Lowe, V. J., Chen, Q., Przybelski, S. A., Lesnick, T. G., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Jack, C. R., Graff-Radford, J., Jones, D. T., Knopman, D. S., Graff-Radford, N., Ferman, T. J., Parisi, J. E., Dickson, D. W., Petersen, R. C., Boeve, B. F. & Murray, M. E., Jan 21 2020, In : Neurology. 94, 3, p. e282-e291

Research output: Contribution to journalArticle

Open Access
2019
5 Scopus citations

A blood-based signature of cerebrospinal fluid Aβ 1–42 status

Alzheimer’s Disease Metabolomics Consortium & Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 4163.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

A Comparison of Partial Volume Correction Techniques for Measuring Change in Serial Amyloid PET SUVR

Schwarz, C. G., Gunter, J. L., Lowe, V. J., Weigand, S., Vemuri, P., Senjem, M. L., Petersen, R. C., Knopman, D. S. & Jack, C. R., 2019, In : Journal of Alzheimer's Disease. 67, 1, p. 181-195 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

Amyloid, Vascular, and Resilience Pathways Associated with Cognitive Aging

Vemuri, P., Lesnick, T. G., Knopman, D. S., Przybelski, S. A., Reid, R. I., Mielke, M. M., Graff-Radford, J., Lowe, V. J., Machulda, M. M., Petersen, R. C. & Jack, C. R., Jan 1 2019, (Accepted/In press) In : Annals of neurology.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

the Dominantly Inherited Alzheimer Network (DIAN), Nov 1 2019, In : Nature Neuroscience. 22, 11, p. 1903-1912 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

An Evaluation of the Progressive Supranuclear Palsy Speech/Language Variant

Whitwell, J. L., Stevens, C. A., Duffy, J. R., Clark, H. M., Machulda, M. M., Strand, E. A., Martin, P. R., Utianski, R. L., Botha, H., Spychalla, A. J., Senjem, M. L., Schwarz, C. G., Jack, C. R., Ali, F., Hassan, A. & Josephs, K. A., Jul 2019, In : Movement Disorders Clinical Practice. 6, 6, p. 452-461 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data

The Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 19589.

Research output: Contribution to journalArticle

Open Access

Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration

Bejanin, A., Murray, M. E., Martin, P., Botha, H., Tosakulwong, N., Schwarz, C. G., Senjem, M. L., Chételat, G., Kantarci, K., Jack, C. R., Boeve, B. F., Knopman, D. S., Petersen, R. C., Giannini, C., Parisi, J. E., Dickson, D. W., Whitwell, J. L. & Josephs, K. A., Nov 1 2019, In : Brain. 142, 11, p. 3621-3635 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

APOE and cortical superficial siderosis in CAA: Meta-analysis and potential mechanisms

Charidimou, A., Zonneveld, H. I., Shams, S., Kantarci, K., Shoamanesh, A., Hilal, S., Yates, P. A., Boulouis, G., Na, H. K., Pasi, M., Biffi, A., Chai, Y. L., Chong, J. R., Wahlund, L. O., Clifford, J. R., Chen, C., Gurol, M. E., Goldstein, J. N., Na, D. L., Barkhof, F. & 4 others, Seo, S. W., Rosand, J., Greenberg, S. M. & Viswanathan, A., Jul 23 2019, In : Neurology. 93, 4, p. E358-E371

Research output: Contribution to journalArticle

2 Scopus citations

Association between white matter hyperintensities, cortical volumes, and late-onset epilepsy

Johnson, E. L., Krauss, G. L., Lee, A. K., Schneider, A. L. C., Kucharska-Newton, A. M., Huang, J., Jack, C. R. J. & Gottesman, R. F., Feb 26 2019, In : Neurology. 92, 9, p. e988-e995

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Association of Atrial Fibrillation With White Matter Disease: The ARIC Study

Shao, I. Y., Power, M. C., Mosley, T., Jack, C., Gottesman, R. F., Chen, L. Y., Norby, F. L., Soliman, E. Z. & Alonso, A., Apr 1 2019, In : Stroke. 50, 4, p. 989-991 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Association of Brain Magnetic Resonance Imaging Signs With Cognitive Outcomes in Persons With Nonimpaired Cognition and Mild Cognitive Impairment

Wu, A., Sharrett, A. R., Gottesman, R. F., Power, M. C., Mosley, T. H., Jack, C. R., Knopman, D. S., Windham, B. G., Gross, A. L. & Coresh, J., May 3 2019, In : JAMA Network Open. 2, 5, p. e193359

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access

Association of white matter microstructural integrity with cognition and dementia

Power, M. C., Su, D., Wu, A., Reid, R. I., Jack, C. R., Knopman, D. S., Coresh, J., Huang, J., Kantarci, K., Sharrett, A. R., Gottesman, R. G., Griswold, M. E. & Mosley, T. H., Nov 2019, In : Neurobiology of aging. 83, p. 63-72 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Atrial Fibrillation, Brain Volumes, and Subclinical Cerebrovascular Disease (from the Atherosclerosis Risk in Communities Neurocognitive Study [ARIC-NCS])

Moazzami, K., Shao, I. Y., Chen, L. Y., Lutsey, P. L., Jack, C. R., Mosley, T., Joyner, D. A., Gottesman, R. & Alonso, A., Jan 1 2019, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

5 Scopus citations

Cardiometabolic Health and Longitudinal Progression of White Matter Hyperintensity: The Mayo Clinic Study of Aging

Scharf, E. L., Graff-Radford, J., Przybelski, S. A., Lesnick, T. G., Mielke, M. M., Knopman, D. S., Preboske, G. M., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Machulda, M., Kantarci, K., Petersen, R. C., Jack, C. R. & Vemuri, P., Nov 1 2019, In : Stroke. 50, 11, p. 3037-3044 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Central arterial stiffness is associated with structural brain damage and poorer cognitive performance: The ARIC study

Palta, P., Sharrett, A. R., Wei, J., Meyer, M. L., Kucharska-Newton, A., Power, M. C., Deal, J. A., Jack, C. R., Knopman, D., Wright, J., Griswold, M., Tanaka, H., Mosley, T. H. & Heiss, G., Jan 1 2019, In : Journal of the American Heart Association. 8, 2, e011045.

Research output: Contribution to journalArticle

6 Scopus citations

Cerebral microbleeds: Prevalence and relationship to amyloid burden

Graff-Radford, J., Botha, H., Rabinstein, A., Gunter, J. L., Przybelski, S. A., Lesnick, T., Huston, J., Flemming, K., Preboske, G. M., Senjem, M. L., Brown, R. D. J., Mielke, M. M., Roberts, R. O., Lowe, V., Knopman, D. S., Petersen, R. C., Kremers, W. K., Vemuri, P. D., Jack, C. R. J. & Kantarci, K. M., Jan 15 2019, In : Neurology. 92, 3, p. e253-e262

Research output: Contribution to journalArticle

8 Scopus citations

Cerebrospinal fluid dynamics disorders: Relationship to Alzheimer biomarkers and cognition

Graff-Radford, J., Gunter, J. L., Jones, D. T., Przybelski, S. A., Schwarz, C. G., Huston, J., Lowe, V., Elder, B. D., MacHulda, M. M., Gunter, N. B., Petersen, R. C., Kantarci, K., Vemuri, P., Mielke, M. M., Knopman, D. S., Graff-Radford, N. R. & Jack, C. R., Dec 10 2019, In : Neurology. 93, 24, p. E2237-E2246

Research output: Contribution to journalArticle

Clinical and neuroimaging characteristics of clinically unclassifiable primary progressive aphasia

Utianski, R. L., Botha, H., Martin, P. R., Schwarz, C. G., Duffy, J. R., Clark, H. M., Machulda, M. M., Butts, A. M., Lowe, V. J., Jack, C. R., Senjem, M. L., Spychalla, A. J., Whitwell, J. L. & Josephs, K. A., Oct 1 2019, In : Brain and Language. 197, 104676.

Research output: Contribution to journalArticle

2 Scopus citations

Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies

Su, Y., Flores, S., Wang, G., Hornbeck, R. C., Speidel, B., Joseph-Mathurin, N., Vlassenko, A. G., Gordon, B. A., Koeppe, R. A., Klunk, W. E., Jack, C. R., Farlow, M. R., Salloway, S., Snider, B. J., Berman, S. B., Roberson, E. D., Brosch, J., Jimenez-Velazques, I., van Dyck, C. H., Galasko, D. & 25 others, Yuan, S. H., Jayadev, S., Honig, L. S., Gauthier, S., Hsiung, G. Y. R., Masellis, M., Brooks, W. S., Fulham, M., Clarnette, R., Masters, C. L., Wallon, D., Hannequin, D., Dubois, B., Pariente, J., Sanchez-Valle, R., Mummery, C., Ringman, J. M., Bottlaender, M., Klein, G., Milosavljevic-Ristic, S., McDade, E., Xiong, C., Morris, J. C., Bateman, R. J. & Benzinger, T. L. S., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 180-190 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations