Clifford R Jr. Jack, MD

  • 83188 Citations
  • 139 Scopus h-Index
1984 …2020

Research output per year

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Research Output

2020

Alzheimer Disease, Biomarkers, and Clinical Symptoms-Quo Vadis?-Reply

Jack, C. R., Jan 1 2020, (Accepted/In press) In : JAMA neurology.

Research output: Contribution to journalLetter

Aortic Stiffness and White Matter Microstructural Integrity Assessed by Diffusion Tensor Imaging: The ARIC-NCS

Wei, J., Palta, P., Meyer, M. L., Kucharska-Newton, A., Pence, B. W., Aiello, A. E., Power, M. C., Walker, K. A., Sharrett, A. R., Tanaka, H., Jack, C. R., Mosley, T. H., Reid, R. I., Reyes, D. A. & Heiss, G., Mar 17 2020, In : Journal of the American Heart Association. 9, 6, p. e014868

Research output: Contribution to journalArticle

Open Access

Brain amyloid, cortical thickness, and changes in activities of daily living

Vassilaki, M., Aakre, J. A., Kremers, W. K., Lesnick, T. G., Mielke, M. M., Geda, Y. E., Machulda, M. M., Knopman, D. S., Butler, L., Traber, M., Vemuri, P., Lowe, V. J., Jack, C. R., Roberts, R. O. & Petersen, R. C., Jan 1 2020, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

Open Access

Brain imaging measurements of fibrillar amyloid-β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele

Ghisays, V., Goradia, D. D., Protas, H., Bauer, R. J., Devadas, V., Tariot, P. N., Lowe, V. J., Knopman, D. S., Petersen, R. C., Jack, C. R., Caselli, R. J., Su, Y., Chen, K. & Reiman, E. M., Apr 1 2020, In : Alzheimer's and Dementia. 16, 4, p. 598-609 12 p.

Research output: Contribution to journalArticle

Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants

Whitwell, J. L., Tosakulwong, N., Botha, H., Ali, F., Clark, H. M., Duffy, J. R., Utianski, R. L., Stevens, C. A., Weigand, S. D., Schwarz, C. G., Senjem, M. L., Jack, C. R., Lowe, V. J., Ahlskog, J. E., Dickson, D. W. & Josephs, K. A., 2020, In : NeuroImage: Clinical. 25, 102152.

Research output: Contribution to journalArticle

Open Access

Cardiorespiratory Fitness and Brain Volumes

Petersen, R. C., Joyner, M. J. & Jack, C. R., Jan 2020, In : Mayo Clinic proceedings. 95, 1, p. 6-8 3 p.

Research output: Contribution to journalEditorial

Open Access

Cerebral microbleed incidence, relationship to amyloid burden: The Mayo Clinic Study of Aging

Graff-Radford, J., Lesnick, T., Rabinstein, A. A., Gunter, J., Aakre, J., Przybelski, S. A., Spychalla, A. J., Huston, J., Brown, R. D., Mielke, M. M., Lowe, V. J., Knopman, D. S., Petersen, R. C., Jack, C. R., Vemuri, P., Kremers, W. & Kantarci, K., Jan 14 2020, In : Neurology. 94, 2, p. e190-e199

Research output: Contribution to journalArticle

Corrigendum to “Prosodic and phonetic subtypes of primary progressive apraxia of speech” [Brain Lang. 184 (2018) 54–65](S0093934X17302638)(10.1016/j.bandl.2018.06.004)

Utianski, R. L., Duffy, J. R., Clark, H. M., Strand, E. A., Botha, H., Schwarz, C. G., Machulda, M. M., Senjem, M. L., Spychalla, A. J., Jack, C. R., Petersen, R. C., Lowe, V. J., Whitwell, J. L. & Josephs, K. A., Jun 2020, In : Brain and Language. 205, 104792.

Research output: Contribution to journalComment/debate

Open Access

Effect Modifiers of TDP-43-Associated Hippocampal Atrophy Rates in Patients with Alzheimer's Disease Neuropathological Changes

Buciuc, M., Wennberg, A. M., Weigand, S. D., Murray, M. E., Senjem, M. L., Spychalla, A. J., Boeve, B. F., Knopman, D. S., Jack, C. R., Kantarci, K., Parisi, J. E., Dickson, D. W., Petersen, R. C., Whitwell, J. L. & Josephs, K. A., Jan 1 2020, In : Journal of Alzheimer's Disease. 73, 4, p. 1511-1523 13 p.

Research output: Contribution to journalArticle

Exposure to surgery with general anaesthesia during adult life is not associated with increased brain amyloid deposition in older adults

Sprung, J., Warner, D. O., Knopman, D. S., Petersen, R. C., Mielke, M. M., Jack, C. R., Lowe, V. J., Martin, D. P., Hanson, A. C., Schroeder, D. R., Przybelski, S. A., Schulte, P. J., Weingarten, T. N. & Vemuri, P., May 2020, In : British journal of anaesthesia. 124, 5, p. 594-602 9 p.

Research output: Contribution to journalArticle

Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis

Zeydan, B., Lowe, V. J., Reichard, R. R., Przybelski, S. A., Lesnick, T. G., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Parisi, J. E., Machulda, M. M., Vemuri, P., Mielke, M. M., Knopman, D. S., Petersen, R. C., Jack, C. R., Kantarci, O. H. & Kantarci, K., Apr 1 2020, In : Annals of neurology. 87, 4, p. 556-567 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Linear vs volume measures of ventricle size: Relation to present and future gait and cognition

Crook, J. E., Gunter, J. L., Ball, C. T., Jones, D. T., Graff-Radford, J., Knopman, D. S., Boeve, B. F., Petersen, R. C., Jack, C. R. & Graff-Radford, N. R., Feb 4 2020, In : Neurology. 94, 5, p. e549-e556

Research output: Contribution to journalArticle

Longitudinal amyloid-β PET in atypical Alzheimer's disease and frontotemporal lobar degeneration

Whitwell, J. L., Tosakulwong, N., Weigand, S. D., Graff-Radford, J., Duffy, J. R., Clark, H. M., Machulda, M. M., Botha, H., Utianski, R. L., Schwarz, C. G., Senjem, M. L., Strand, E. A., Ertekin-Taner, N., Jack, C. R., Lowe, V. J. & Josephs, K. A., Jan 1 2020, In : Journal of Alzheimer's Disease. 74, 1, p. 377-389 13 p.

Research output: Contribution to journalArticle

Longitudinal flortaucipir ([18F]AV-1451) PET imaging in primary progressive apraxia of speech

Utianski, R. L., Martin, P. R., Botha, H., Schwarz, C. G., Duffy, J. R., Petersen, R. C., Knopman, D. S., Clark, H. M., Butts, A. M., Machulda, M. M., Jack, C. R., Lowe, V. J., Whitwell, J. L. & Josephs, K. A., Mar 2020, In : Cortex. 124, p. 33-43 11 p.

Research output: Contribution to journalArticle

MRI and flortaucipir relationships in Alzheimer's phenotypes are heterogeneous

Josephs, K. A., Tosakulwong, N., Graff-Radford, J., Weigand, S. D., Buciuc, M., Machulda, M. M., Jones, D. T., Schwarz, C. G., Senjem, M. L., Ertekin-Taner, N., Kantarci, K., Boeve, B. F., Knopman, D. S., Jack, C. R., Petersen, R. C., Lowe, V. J. & Whitwell, J. L., Jan 1 2020, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

Open Access

Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia

Petroi, D., Duffy, J. R., Borgert, A., Strand, E. A., Machulda, M. M., Senjem, M. L., Jack, C. R., Josephs, K. A. & Whitwell, J. L., May 2020, In : Brain and Language. 204, 104773.

Research output: Contribution to journalArticle

Preclinical Alzheimer's disease: a valid concept

Jack, C. R., Jan 2020, In : The Lancet Neurology. 19, 1, 1 p.

Research output: Contribution to journalLetter

Open Access

The transformative potential of plasma phosphorylated tau

Jack, C. R., May 2020, In : The Lancet Neurology. 19, 5, p. 373-374 2 p.

Research output: Contribution to journalComment/debate

Trajectory of lobar atrophy in asymptomatic and symptomatic GRN mutation carriers: a longitudinal MRI study

Chen, Q., Boeve, B. F., Senjem, M., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J., Forsberg, L., Gavrilova, R., Gearhart, D., Graff-Radford, J., Graff-Radford, N., Jack, C. R., Jones, D., Knopman, D., Kremers, W. K., Lapid, M., Rademakers, R., Ramos, E. M. & 5 others, Syrjanen, J., Boxer, A. L., Rosen, H., Wszolek, Z. K. & Kantarci, K., Jan 1 2020, (Accepted/In press) In : Neurobiology of aging.

Research output: Contribution to journalArticle

1 Scopus citations

β-Amyloid PET and neuropathology in dementia with Lewy bodies

Kantarci, K., Lowe, V. J., Chen, Q., Przybelski, S. A., Lesnick, T. G., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Jack, C. R., Graff-Radford, J., Jones, D. T., Knopman, D. S., Graff-Radford, N., Ferman, T. J., Parisi, J. E., Dickson, D. W., Petersen, R. C., Boeve, B. F. & Murray, M. E., Jan 21 2020, In : Neurology. 94, 3, p. e282-e291

Research output: Contribution to journalArticle

Open Access
2019
5 Scopus citations

A blood-based signature of cerebrospinal fluid Aβ 1–42 status

Alzheimer’s Disease Metabolomics Consortium & Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific reports. 9, 1, 4163.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

A brief history of "Alzheimer disease": Multiple meanings separated by a common name

Knopman, D. S., Petersen, R. C. & Jack, C. R. J., May 28 2019, In : Neurology. 92, 22, p. 1053-1059 7 p.

Research output: Contribution to journalReview article

8 Scopus citations

A Comparison of Partial Volume Correction Techniques for Measuring Change in Serial Amyloid PET SUVR

Schwarz, C., Gunter, J. L., Lowe, V., Weigand, S., Vemuri, P. D., Senjem, M. L., Petersen, R. C., Knopman, D. S. & Jack, C. R. J., Jan 1 2019, In : Journal of Alzheimer's Disease. 67, 1, p. 181-195 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

A Joint Model for Predicting Structural and Functional Brain Health in Elderly Individuals

Varatharajah, Y., Saboo, K., Iyer, R., Przybelski, S., Schwarz, C., Petersen, R., Jack, C. & Vemuri, P., Nov 2019, Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019. Yoo, I., Bi, J. & Hu, X. T. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 1657-1664 8 p. 8983291. (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Amyloid, Vascular, and Resilience Pathways Associated with Cognitive Aging

Vemuri, P., Lesnick, T. G., Knopman, D. S., Przybelski, S. A., Reid, R. I., Mielke, M. M., Graff-Radford, J., Lowe, V. J., Machulda, M. M., Petersen, R. C. & Jack, C. R., Jan 1 2019, (Accepted/In press) In : Annals of neurology.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2 Scopus citations

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

the Dominantly Inherited Alzheimer Network (DIAN), Nov 1 2019, In : Nature Neuroscience. 22, 11, p. 1903-1912 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

An Evaluation of the Progressive Supranuclear Palsy Speech/Language Variant

Whitwell, J. L., Stevens, C. A., Duffy, J. R., Clark, H., Machulda, M. M., Strand, E. A., Martin, P. R., Utianski, R., Botha, H., Spychalla, A. J., Senjem, M. L., Schwarz, C., Jack, C. R. J., Ali, F., Hassan, A. & Josephs, K. A., Jan 1 2019, In : Movement Disorders Clinical Practice.

Research output: Contribution to journalArticle

2 Scopus citations

Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration

Bejanin, A., Murray, M. E., Martin, P., Botha, H., Tosakulwong, N., Schwarz, C. G., Senjem, M. L., Chételat, G., Kantarci, K., Jack, C. R., Boeve, B. F., Knopman, D. S., Petersen, R. C., Giannini, C., Parisi, J. E., Dickson, D. W., Whitwell, J. L. & Josephs, K. A., Nov 1 2019, In : Brain. 142, 11, p. 3621-3635 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

APOE and cortical superficial siderosis in CAA: Meta-analysis and potential mechanisms

Charidimou, A., Zonneveld, H. I., Shams, S., Kantarci, K., Shoamanesh, A., Hilal, S., Yates, P. A., Boulouis, G., Na, H. K., Pasi, M., Biffi, A., Chai, Y. L., Chong, J. R., Wahlund, L. O., Clifford, J. R., Chen, C., Gurol, M. E., Goldstein, J. N., Na, D. L., Barkhof, F. & 4 others, Seo, S. W., Rosand, J., Greenberg, S. M. & Viswanathan, A., Jul 23 2019, In : Neurology. 93, 4, p. E358-E371

Research output: Contribution to journalArticle

Association between white matter hyperintensities, cortical volumes, and late-onset epilepsy

Johnson, E. L., Krauss, G. L., Lee, A. K., Schneider, A. L. C., Kucharska-Newton, A. M., Huang, J., Jack, C. R. J. & Gottesman, R. F., Feb 26 2019, In : Neurology. 92, 9, p. e988-e995

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Association of Atrial Fibrillation With White Matter Disease: The ARIC Study

Shao, I. Y., Power, M. C., Mosley, T., Jack, C., Gottesman, R. F., Chen, L. Y., Norby, F. L., Soliman, E. Z. & Alonso, A., Apr 1 2019, In : Stroke. 50, 4, p. 989-991 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Association of Brain Magnetic Resonance Imaging Signs With Cognitive Outcomes in Persons With Nonimpaired Cognition and Mild Cognitive Impairment

Wu, A., Sharrett, A. R., Gottesman, R. F., Power, M. C., Mosley, T. H., Jack, C. R., Knopman, D. S., Windham, B. G., Gross, A. L. & Coresh, J., May 3 2019, In : JAMA Network Open. 2, 5, p. e193359

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Association of Longitudinal β-Amyloid Accumulation Determined by Positron Emission Tomography With Clinical and Cognitive Decline in Adults With Probable Lewy Body Dementia

Nedelska, Z., Schwarz, C. G., Lesnick, T. G., Boeve, B. F., Przybelski, S. A., Lowe, V. J., Kremers, W. K., Gunter, J. L., Senjem, M. L., Graff-Radford, J., Ferman, T. J., Fields, J. A., Knopman, D. S., Petersen, R. C., Jack, C. R. & Kantarci, K., Dec 2 2019, In : JAMA Network Open. 2, 12, p. e1916439

Research output: Contribution to journalArticle

Open Access

Association of white matter microstructural integrity with cognition and dementia

Power, M. C., Su, D., Wu, A., Reid, R. I., Jack, C. R., Knopman, D. S., Coresh, J., Huang, J., Kantarci, K., Sharrett, A. R., Gottesman, R. G., Griswold, M. E. & Mosley, T. H., Nov 2019, In : Neurobiology of aging. 83, p. 63-72 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Atrial Fibrillation, Brain Volumes, and Subclinical Cerebrovascular Disease (from the Atherosclerosis Risk in Communities Neurocognitive Study [ARIC-NCS])

Moazzami, K., Shao, I. Y., Chen, L. Y., Lutsey, P. L., Jack, C. R., Mosley, T., Joyner, D. A., Gottesman, R. & Alonso, A., Jan 1 2019, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

5 Scopus citations

Cardiometabolic Health and Longitudinal Progression of White Matter Hyperintensity: The Mayo Clinic Study of Aging

Scharf, E. L., Graff-Radford, J., Przybelski, S. A., Lesnick, T. G., Mielke, M. M., Knopman, D. S., Preboske, G. M., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Machulda, M., Kantarci, K., Petersen, R. C., Jack, C. R. & Vemuri, P., Nov 1 2019, In : Stroke. 50, 11, p. 3037-3044 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Central Arterial Stiffness Is Associated With Structural Brain Damage and Poorer Cognitive Performance: The ARIC Study

Palta, P., Sharrett, A. R., Wei, J., Meyer, M. L., Kucharska-Newton, A., Power, M. C., Deal, J. A., Jack, C. R. J., Knopman, D. S., Wright, J., Griswold, M., Tanaka, H., Mosley, T. H. & Heiss, G., Jan 22 2019, In : Journal of the American Heart Association. 8, 2, p. e011045

Research output: Contribution to journalArticle

5 Scopus citations

Cerebral microbleeds: Prevalence and relationship to amyloid burden

Graff-Radford, J., Botha, H., Rabinstein, A., Gunter, J. L., Przybelski, S. A., Lesnick, T., Huston, J., Flemming, K., Preboske, G. M., Senjem, M. L., Brown, R. D. J., Mielke, M. M., Roberts, R. O., Lowe, V., Knopman, D. S., Petersen, R. C., Kremers, W. K., Vemuri, P. D., Jack, C. R. J. & Kantarci, K. M., Jan 15 2019, In : Neurology. 92, 3, p. e253-e262

Research output: Contribution to journalArticle

7 Scopus citations

Cerebrospinal fluid dynamics disorders: Relationship to Alzheimer biomarkers and cognition

Graff-Radford, J., Gunter, J. L., Jones, D. T., Przybelski, S. A., Schwarz, C. G., Huston, J., Lowe, V., Elder, B. D., MacHulda, M. M., Gunter, N. B., Petersen, R. C., Kantarci, K., Vemuri, P., Mielke, M. M., Knopman, D. S., Graff-Radford, N. R. & Jack, C. R., Dec 10 2019, In : Neurology. 93, 24, p. E2237-E2246

Research output: Contribution to journalArticle

Clinical and neuroimaging characteristics of clinically unclassifiable primary progressive aphasia

Utianski, R., Botha, H., Martin, P. R., Schwarz, C., Duffy, J. R., Clark, H., Machulda, M. M., Butts, A., Lowe, V., Jack, C. R. J., Senjem, M. L., Spychalla, A. J., Whitwell, J. L. & Josephs, K. A., Oct 1 2019, In : Brain and Language. 197, 104676.

Research output: Contribution to journalArticle

1 Scopus citations

Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies

Su, Y., Flores, S., Wang, G., Hornbeck, R. C., Speidel, B., Joseph-Mathurin, N., Vlassenko, A. G., Gordon, B. A., Koeppe, R. A., Klunk, W. E., Jack, C. R., Farlow, M. R., Salloway, S., Snider, B. J., Berman, S. B., Roberson, E. D., Brosch, J., Jimenez-Velazques, I., van Dyck, C. H., Galasko, D. & 25 others, Yuan, S. H., Jayadev, S., Honig, L. S., Gauthier, S., Hsiung, G. Y. R., Masellis, M., Brooks, W. S., Fulham, M., Clarnette, R., Masters, C. L., Wallon, D., Hannequin, D., Dubois, B., Pariente, J., Sanchez-Valle, R., Mummery, C., Ringman, J. M., Bottlaender, M., Klein, G., Milosavljevic-Ristic, S., McDade, E., Xiong, C., Morris, J. C., Bateman, R. J. & Benzinger, T. L. S., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 180-190 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin

Mielke, M. M., Syrjanen, J. A., Blennow, K., Zetterberg, H., Skoog, I., Vemuri, P., Machulda, M. M., Graff-Radford, J., Knopman, D. S., Jack, C. R., Petersen, R. C. & Kern, S., Nov 2019, In : Alzheimer's and Dementia. 15, 11, p. 1437-1447 11 p.

Research output: Contribution to journalArticle

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging

Krell-Roesch, J., Vassilaki, M., Mielke, M. M., Kremers, W. K., Lowe, V. J., Vemuri, P., Machulda, M. M., Christianson, T. J., Syrjanen, J. A., Stokin, G. B., Butler, L. M., Traber, M., Jack, C. R., Knopman, D. S., Roberts, R. O., Petersen, R. C. & Geda, Y. E., Dec 1 2019, In : Translational psychiatry. 9, 1, 123.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V. J., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M. K., Murray, M. E., Kantarci, K., Jones, D. T., Vemuri, P., Graff-Radford, J., Schwarz, C. G., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R., Jul 2 2019, In : Neurology. 93, 1, p. e29-e39

Research output: Contribution to journalArticle

6 Scopus citations

Dementia is not synonymous with Alzheimer’s disease

Jack, C., Holtzman, D. & Sperling, R., Dec 11 2019, In : Science translational medicine. 11, 522, eaav0511.

Research output: Contribution to journalEditorial

2 Scopus citations