• 6898 Citations
  • 50 Scopus h-Index
1984 …2020

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Article

Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon

Calcagno, S. R., Li, S., Colon, M., Kreinest, P. A., Thompson, E. A., Fields, A. P. & Murray, N. R., Jun 1 2008, In : International Journal of Cancer. 122, 11, p. 2462-2470 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
1 Scopus citations

Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer

Deng, X., Cao, Y., Liu, Y., Li, F., Sambandam, K., Rajaraman, S., Perkins, A. S., Fields, A. P., Hellmich, M. R., Townsend, C. M., Thompson, E. A. & Ko, T. C., Apr 1 2013, In : Molecular Carcinogenesis. 52, 4, p. 255-264 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Overexpression of protein kinase C β(II) induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis

Murray, N. R., Davidson, L. A., Chapkin, R. S., Gustafson, W. C., Schattenberg, D. G. & Fields, A. P., May 17 1999, In : Journal of Cell Biology. 145, 4, p. 699-711 13 p.

Research output: Contribution to journalArticle

145 Scopus citations

Peroxisome proliferator-activated receptor γ promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2

Chen, L., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Aug 25 2006, In : Journal of Biological Chemistry. 281, 34, p. 24575-24587 13 p.

Research output: Contribution to journalArticle

46 Scopus citations
34 Scopus citations

Phosphatidylglycerol is a novel activator of nuclear protein kinase

Murray, C. N. R. & Fields, A. P., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1349

Research output: Contribution to journalArticle

Phosphatidylglycerol is a physiologic activator of nuclear protein kinase C

Murray, N. R. & Fields, A. P., May 8 1998, In : Journal of Biological Chemistry. 273, 19, p. 11514-11520 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C

Fields, A. P., Pettit, G. R. & May, W. S., Jan 1 1988, In : Journal of Biological Chemistry. 263, 17, p. 8253-8260 8 p.

Research output: Contribution to journalArticle

119 Scopus citations

Pituitary expression of protein kinase C isotypes during early development

Korytko, A. I., Fields, A. P., Allshouse, L. A. & Cuttler, L., Aug 1 1998, In : Journal of Neuroendocrinology. 10, 8, p. 569-576 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

PKCi maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis

Wang, Y., Hill, K. S. & Fields, A. P., Dec 1 2013, In : Molecular Cancer Research. 11, 12, p. 1624-1635 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis

Wang, Y., Justilien, V., Brennan, K. I., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 20 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

20 Scopus citations

Presence and Activation of Nuclear Phosphoinositide 3-Kinase C2β during Compensatory Liver Growth

Sindić, A., Aleksandrova, A., Fields, A. P., Volinia, S. & Banfić, H., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 17754-17761 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Presence of a β(II) protein kinase C-selective nuclear membrane activation factor in human leukemia cells

Murray, N. R., Burns, D. J. & Fields, A. P., Jan 1 1994, In : Journal of Biological Chemistry. 269, 33, p. 21385-21390 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Protein kinase c (PKC) βII induces cell invasion through a Ras/Mek-, PKCι/Rac 1-dependent signaling pathway

Zhang, J., Anastasiadis, P. Z., Liu, Y., Thompson, E. A. & Fields, A. P., May 21 2004, In : Journal of Biological Chemistry. 279, 21, p. 22118-22123 6 p.

Research output: Contribution to journalArticle

117 Scopus citations

Protein kinase C beta;II regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo

Liu, Y., Su, W., Thompson, E. A., Leitges, M., Murray, N. R. & Fields, A. P., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 45556-45563 8 p.

Research output: Contribution to journalArticle

44 Scopus citations
Open Access
38 Scopus citations

Protein kinase C in disease: cancer.

Fields, A. P. & Gustafson, W. C., 2003, In : Methods in molecular biology (Clifton, N.J.). 233, p. 519-537 19 p.

Research output: Contribution to journalArticle

36 Scopus citations

Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma

Kikuchi, K., Soundararajan, A., Zarzabal, L. A., Weems, C. R., Nelon, L. D., Hampton, S. T., Michalek, J. E., Rubin, B. P., Fields, A. P. & Keller, C., Jan 17 2013, In : Oncogene. 32, 3, p. 286-295 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis

Calcagno, S. R., Li, S., Shahid, M. W., Wallace, M. B., Leitges, M., Fields, A. P. & Murray, N. R., Aug 1 2011, In : Inflammatory bowel diseases. 17, 8, p. 1685-1697 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia

Scotti, M. L., Smith, K. E., Butler, A. M., Calcagno, S. R., Crawford, H. C., Leitges, M., Fields, A. P. & Murray, N. R., Feb 16 2012, In : PloS one. 7, 2, e30509.

Research output: Contribution to journalArticle

11 Scopus citations

Protein kinase C isoforms in human glioblastoma cells

Misra‐Press, A., Fields, A. P., Samols, D. & Goldthwait, D. A., 1992, In : Glia. 6, 3, p. 188-197 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
188 Scopus citations

Protein kinase C isotypes in human erythroleukemia cell proliferation and differentiation

Hocevar, B. A., Morrow, D. M., Tykocinski, M. L. & Fields, A. P., Jan 1 1992, In : Journal of cell science. 101, 3, p. 671-679 9 p.

Research output: Contribution to journalArticle

87 Scopus citations

Protein kinase C isozymes and the regulation of diverse cell responses

Dempsey, E. C., Newton, A. C., Mochly-Rosen, D., Fields, A. P., Reyland, M. E., Insel, P. A. & Messing, R. O., Jan 1 2000, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 279, 3 23-3, p. L429-L438

Research output: Contribution to journalArticle

665 Scopus citations

Protein kinase C isozymes as therapeutic targets for treatment of human cancers

Fields, A. P. & Murray, N. R., Sep 15 2008, In : Advances in Enzyme Regulation. 48, 1, p. 166-178 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Protein kinase C-mediated interphase lamin B phosphorylation and solubilization

Collas, P., Thompson, L., Fields, A. P., Poccia, D. L. & Courvalin, J. C., Aug 22 1997, In : Journal of Biological Chemistry. 272, 34, p. 21274-21280 7 p.

Research output: Contribution to journalArticle

54 Scopus citations

Protein Kinase C Zeta Regulates Human Pancreatic Cancer Cell Transformed Growth and Invasion through a STAT3-Dependent Mechanism

Butler, A. M., Scotti Buzhardt, M. L., Li, S., Smith, K. E., Fields, A. P. & Murray, N. R., Aug 28 2013, In : PloS one. 8, 8, e72061.

Research output: Contribution to journalArticle

24 Scopus citations

Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1)

O'Neill, A. K., Gallegos, L. L., Justilien, V., Garcia, E. L., Leitges, M., Fields, A. P., Hall, R. A. & Newton, A. C., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43559-43568 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Protein kinase Cα regulates human monocyte O2̇ production and low density lipoprotein lipid oxidation

Li, Q., Subbulakshmi, V., Fields, A. P., Murray, N. R. & Cathcart, M. K., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3764-3771 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis

Hill, K. S., Erdogan, E., Khoor, A., Walsh, M. P., Leitges, M., Murray, N. R. & Fields, A. P., Apr 17 2014, In : Oncogene. 33, 16, p. 2134-2144 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Protein kinase C β from Friend erythroleukemia cells is associated with chromatin and DNA

Mallia, C. M., Jeter, J. R., Fields, A. P., Wilson, R. B. & Beckman, B. S., Oct 1 1995, In : Molecular and Cellular Biochemistry. 151, 2, p. 107-111 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Protein kinase C βII and PKCι/λ: Collaborating partners in colon cancer promotion and progression

Murray, N. R., Weems, J., Braun, U., Leitges, M. & Fields, A. P., Jan 15 2009, In : Cancer research. 69, 2, p. 656-662 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Protein kinase C βII and TGFβRII in ω-3 fatty acid-mediated inhibition of colon carcinogenesis

Murray, N. R., Weems, C., Chen, L., Leon, J., Wangsheng, W., Davidson, L. A., Jamieson, L., Chapkin, R. S., Aubrey Thompson, E. & Fields, A. P., Jun 10 2002, In : Journal of Cell Biology. 157, 6, p. 915-920 6 p.

Research output: Contribution to journalArticle

61 Scopus citations

Protein kinase cβ is an effective target for chemoprevention of colon cancer

Fields, A. P., Calcagno, S. R., Krishna, M., Rak, S., Leitges, M. & Murray, N. R., Feb 15 2009, In : Cancer research. 69, 4, p. 1643-1650 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Protein kinase Cι: A versatile oncogene in the lung

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Oncology. e1190886.

Research output: Contribution to journalArticle

Protein kinase Cι activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis

Jamieson, L., Carpenter, L., Biden, T. J. & Fields, A. P., Feb 12 1999, In : Journal of Biological Chemistry. 274, 7, p. 3927-3930 4 p.

Research output: Contribution to journalArticle

96 Scopus citations

Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma

Yin, N., Liu, Y., Khoor, A., Wang, X., Thompson, E. A., Leitges, M., Justilien, V., Weems, C., Murray, N. R. & Fields, A. P., Aug 12 2019, In : Cancer cell. 36, 2, p. 156-167.e7

Research output: Contribution to journalArticle

3 Scopus citations

Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

Ali, S. A., Justilien, V., Jamieson, L., Murray, N. R. & Fields, A. P., Mar 14 2016, In : Cancer Cell. 29, 3, p. 367-378 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Protein kinase Cι is required for pancreatic cancer cell transformed growth and tumorigenesis

Scotti, M. L., Bamlet, W. R., Smyrk, T. C., Fields, A. P. & Murray, N. R., Mar 1 2010, In : Cancer research. 70, 5, p. 2064-2074 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo

Murray, N. R., Jamieson, L., Yu, W., Zhang, J., Gökmen-Polar, Y., Sier, D., Anastasiadis, P., Gatalica, Z., Thompson, E. A. & Fields, A. P., Mar 15 2004, In : Journal of Cell Biology. 164, 6, p. 797-802 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

Liou, G. Y., Döppler, H., Braun, U. B., Panayiotou, R., Scotti Buzhardt, M., Radisky, D. C., Crawford, H. C., Fields, A. P., Murray, N. R., Wang, Q. J., Leitges, M. & Storz, P., Feb 20 2015, In : Nature communications. 6, 6200.

Research output: Contribution to journalArticle

36 Scopus citations

Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction

Rudolph, J. L., Shi, G. X., Erdogan, E., Fields, A. P. & Andres, D. A., Dec 1 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 12, p. 1793-1800 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Role of cyclooxygenase 2 in protein kinase C βII-mediated colon carcinogenesis

Yu, W., Murray, N. R., Weems, C., Chen, L., Guo, H., Ethridge, R., Ceci, J. D., Evers, B. M., Thompson, E. A. & Fields, A. P., Mar 28 2003, In : Journal of Biological Chemistry. 278, 13, p. 11167-11174 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Role of nuclear protein kinase C in the mitogenic response to platelet-derived growth factor

Fields, A. P., Tyler, G., Kraft, A. S. & Stratford May, W., Jun 5 1990, In : Journal of cell science. 96, 1, p. 107-114 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

RS5444, a novel PPARγ agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells

Chen, L., Bush, C. R., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Jun 7 2006, In : Molecular and Cellular Endocrinology. 251, 1-2, p. 17-32 16 p.

Research output: Contribution to journalArticle

28 Scopus citations

Selective translocation of β(II)-protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells

Hocevar, B. A. & Fields, A. P., Jan 31 1991, In : Journal of Biological Chemistry. 266, 1, p. 28-33 6 p.

Research output: Contribution to journalArticle

220 Scopus citations

Splice variants of SmgGDS control small gtpase prenylation and membrane localization

Berg, T. J., Gastonguay, A. J., Lorimer, E. L., Kuhnmuench, J. R., Li, R., Fields, A. P. & Williams, C. L., Nov 12 2010, In : Journal of Biological Chemistry. 285, 46, p. 35255-35266 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model

Riabov, V., Yin, S., Song, B., Avdic, A., Schledzewski, K., Ovsiy, I., Gratchev, A., Verdiell, M. L., Sticht, C., Schmuttermaier, C., Schönhaber, H., Weiss, C., Fields, A. P., Simon-Keller, K., Pfister, F., Berlit, S., Marx, A., Arnold, B., Goerdt, S. & Kzhyshkowska, J., May 24 2016, In : Oncotarget. 7, 21, p. 31097-31110 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jun 30 2016, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.

Research output: Contribution to journalArticle

3 Scopus citations