• 6879 Citations
  • 50 Scopus h-Index
1984 …2021

Research output per year

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Research Output

2008

Matrix metalloproteinase-10 is a critical effector of protein kinase Cι-Par6α-mediated lung cancer

Frederick, L. A., Matthews, J. A., Jamieson, L., Justilien, V., Thompson, E. A., Radisky, D. C. & Fields, A. P., Aug 14 2008, In : Oncogene. 27, 35, p. 4841-4853 13 p.

Research output: Contribution to journalArticle

67 Scopus citations

Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon

Calcagno, S. R., Li, S., Colon, M., Kreinest, P. A., Thompson, E. A., Fields, A. P. & Murray, N. R., Jun 1 2008, In : International Journal of Cancer. 122, 11, p. 2462-2470 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Protein kinase C isozymes as therapeutic targets for treatment of human cancers

Fields, A. P. & Murray, N. R., Sep 15 2008, In : Advances in Enzyme Regulation. 48, 1, p. 166-178 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
12 Scopus citations
2007

Differential expression, distribution, and function of PPAR-γ in the proximal and distal colon

Su, W., Bush, C. R., Necela, B. M., Calcagno, S. R., Murray, N. R., Fields, A. P. & Thompson, E. A., Aug 20 2007, In : Physiological Genomics. 30, 3, p. 342-353 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Erratum: Aurothiomalate inhibits transformed growth by targeting the PB1 domain of atypical protein kinase Cι (Journal of Biological Chemistry (2006) 281, (28450-28459))

Erdogan, E., Lamark, T., Stallings-Mann, M., Jamieson, L., Pellecchia, M., Thompson, E. A., Johansen, T. & Fields, A. P., Mar 30 2007, In : Journal of Biological Chemistry. 282, 13, 1 p.

Research output: Contribution to journalComment/debate

Protein kinase Cι: Human oncogene, prognostic marker and therapeutic target

Fields, A. P. & Regala, R. P., Jun 1 2007, In : Pharmacological Research. 55, 6, p. 487-497 11 p.

Research output: Contribution to journalReview article

97 Scopus citations

Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction

Rudolph, J. L., Shi, G. X., Erdogan, E., Fields, A. P. & Andres, D. A., Dec 1 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 12, p. 1793-1800 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Targeting the oncogenic protein kinase Cι signalling pathway for the treatment of cancer

Fields, A. P., Frederick, L. A. & Regala, R. P., Nov 1 2007, In : Biochemical Society Transactions. 35, 5, p. 996-1000 5 p.

Research output: Contribution to journalArticle

51 Scopus citations
2006

A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells

Stailings-Mann, M., Jamieson, L., Regala, R. P., Weems, C., Murray, N. R. & Fields, A. P., Feb 1 2006, In : Cancer research. 66, 3, p. 1767-1774 8 p.

Research output: Contribution to journalArticle

123 Scopus citations

Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ci

Erdogan, E., Lamark, T., Stallings-Mann, M., Jamieson, L., Pellechia, M., Aubrey Thompson, E., Johansen, T. & Fields, A. P., Sep 22 2006, In : Journal of Biological Chemistry. 281, 38, p. 28450-28459 10 p.

Research output: Contribution to journalArticle

74 Scopus citations

Evi1 is a survival factor which conveys resistance to both TGFβ- and taxol-mediated cell death via PI3K/AKT

Liu, Y., Chen, L., Ko, T. C., Fields, A. P. & Thompson, E. A., Jun 15 2006, In : Oncogene. 25, 25, p. 3565-3575 11 p.

Research output: Contribution to journalArticle

75 Scopus citations

Peroxisome proliferator-activated receptor γ promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2

Chen, L., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Aug 25 2006, In : Journal of Biological Chemistry. 281, 34, p. 24575-24587 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

RS5444, a novel PPARγ agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells

Chen, L., Bush, C. R., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Jun 7 2006, In : Molecular and Cellular Endocrinology. 251, 1-2, p. 17-32 16 p.

Research output: Contribution to journalArticle

28 Scopus citations
2005

Atypical protein kinase Cι is an oncogene in human non-small cell lung cancer

Regala, R. P., Weems, C., Jamieson, L., Khoor, A., Edell, E. S., Lohse, C. M. & Fields, A. P., Oct 1 2005, In : Cancer research. 65, 19, p. 8905-8911 7 p.

Research output: Contribution to journalArticle

209 Scopus citations

Atypical protein kinase Cτ plays a critical role in human lung cancer cell growth and tumorigenicity

Regala, R. P., Weems, C., Jamieson, L., Copland, J. A., Thompson, E. A. & Fields, A. P., Sep 2 2005, In : Journal of Biological Chemistry. 280, 35, p. 31109-31115 7 p.

Research output: Contribution to journalArticle

154 Scopus citations
2004

Bcr-Abl Regulates Protein Kinase Cι (PKCι) Transcription via an Elk1 Site in the PKCι Promoter

Gustafson, W. C., Ray, S., Jamieson, L., Thompson, E. A., Brasier, A. R. & Fields, A. P., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9400-9408 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Genomic mechanisms of p210BCR-ABL signaling: Induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis

Ray, S., Lu, Y., Kaufmann, S. H., Gustafson, W. C., Karp, J. E., Boldogh, I., Fields, A. P. & Brasier, A. R., Aug 20 2004, In : Journal of Biological Chemistry. 279, 34, p. 35604-35615 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Protein kinase c (PKC) βII induces cell invasion through a Ras/Mek-, PKCι/Rac 1-dependent signaling pathway

Zhang, J., Anastasiadis, P. Z., Liu, Y., Thompson, E. A. & Fields, A. P., May 21 2004, In : Journal of Biological Chemistry. 279, 21, p. 22118-22123 6 p.

Research output: Contribution to journalArticle

117 Scopus citations

Protein kinase C beta;II regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo

Liu, Y., Su, W., Thompson, E. A., Leitges, M., Murray, N. R. & Fields, A. P., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 45556-45563 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo

Murray, N. R., Jamieson, L., Yu, W., Zhang, J., Gökmen-Polar, Y., Sier, D., Anastasiadis, P., Gatalica, Z., Thompson, E. A. & Fields, A. P., Mar 15 2004, In : Journal of Cell Biology. 164, 6, p. 797-802 6 p.

Research output: Contribution to journalArticle

113 Scopus citations
2003
7 Scopus citations

Genomic Analysis of Glucocorticoid-regulated Promoters in Murine T-lymphoma Cells

Chen, L., Finnerty, C., Gustafson, W. C., Bush, C. R., Chi, P., Guo, H., Luxon, B., Fields, A. P. & Thompson, E. A., Nov 10 2003, In : Recent Progress in Hormone Research. 58, p. 155-174 20 p.

Research output: Contribution to journalReview article

7 Scopus citations

Protein kinase C in disease: cancer.

Fields, A. P. & Gustafson, W. C., 2003, In : Methods in molecular biology (Clifton, N.J.). 233, p. 519-537 19 p.

Research output: Contribution to journalArticle

36 Scopus citations

Quantification of human intestinal gene expression profiles using exfoliated colonocytes: A pilot study

Davidson, L. A., Lupton, J. R., Miskovsky, E., Fields, A. P. & Chapkin, R. S., Jan 1 2003, In : Biomarkers. 8, 1, p. 51-61 11 p.

Research output: Contribution to journalReview article

53 Scopus citations

Rapid backbone 1H, 13C, and 15N assignment of the V1 domain of human PKC iota using the new program IBIS [1]

Roehrl, M. H. A., Hyberts, S. G., Sun, Z. Y. J., Fields, A. P. & Wagner, G., Aug 1 2003, In : Journal of Biomolecular NMR. 26, 4, p. 373-374 2 p.

Research output: Contribution to journalLetter

2 Scopus citations

Role of cyclooxygenase 2 in protein kinase C βII-mediated colon carcinogenesis

Yu, W., Murray, N. R., Weems, C., Chen, L., Guo, H., Ethridge, R., Ceci, J. D., Evers, B. M., Thompson, E. A. & Fields, A. P., Mar 28 2003, In : Journal of Biological Chemistry. 278, 13, p. 11167-11174 8 p.

Research output: Contribution to journalArticle

66 Scopus citations
2002

Protein kinase C βII and TGFβRII in ω-3 fatty acid-mediated inhibition of colon carcinogenesis

Murray, N. R., Weems, C., Chen, L., Leon, J., Wangsheng, W., Davidson, L. A., Jamieson, L., Chapkin, R. S., Aubrey Thompson, E. & Fields, A. P., Jun 10 2002, In : Journal of Cell Biology. 157, 6, p. 915-920 6 p.

Research output: Contribution to journalArticle

61 Scopus citations
2001

Cloning of a novel phosphatidylinositol kinase-related kinase. Characterization of the human SMG-1 RNA surveillance protein

Denning, G., Jamieson, L., Maquat, L. E., Thompson, E. A. & Fields, A. P., Jun 22 2001, In : Journal of Biological Chemistry. 276, 25, p. 22709-22714 6 p.

Research output: Contribution to journalArticle

118 Scopus citations

Elevated protein kinase C βII is an early promotive event in colon carcinogenesis

Gökmen-Polar, Y., Murray, N. R., Velasco, M. A., Gatalica, Z. & Fields, A. P., Feb 15 2001, In : Cancer research. 61, 4, p. 1375-1381 7 p.

Research output: Contribution to journalArticle

168 Scopus citations

Erratum: Presence and activation of nuclear phosphoinositide 3-kinase C2β during compensatory liver growth (Journal Biological Chemistry (2001) 276 (17754-17761))

Sindić, A., Aleksandrova, A., Fields, A. P., Volinia, S. & Banfić, H., Aug 31 2001, In : Journal of Biological Chemistry. 276, 35, 1 p.

Research output: Contribution to journalComment/debate

NF-κB/RelA transactivation is required for atypical protein kinase Cl-mediated cell survival

Lu, Y., Jamieson, L., Brasier, A. R. & Fields, A. P., Aug 9 2001, In : Oncogene. 20, 35, p. 4777-4792 16 p.

Research output: Contribution to journalArticle

60 Scopus citations

Presence and Activation of Nuclear Phosphoinositide 3-Kinase C2β during Compensatory Liver Growth

Sindić, A., Aleksandrova, A., Fields, A. P., Volinia, S. & Banfić, H., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 17754-17761 8 p.

Research output: Contribution to journalArticle

42 Scopus citations
2000

Activation of transcription factor SAF involves its phosphorylation by protein kinase C

Ray, A., Fields, A. P. & Ray, B. K., Dec 15 2000, In : Journal of Biological Chemistry. 275, 50, p. 39727-39733 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Protein kinase C isozymes and the regulation of diverse cell responses

Dempsey, E. C., Newton, A. C., Mochly-Rosen, D., Fields, A. P., Reyland, M. E., Insel, P. A. & Messing, R. O., Oct 4 2000, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 279, 3 23-3, p. L429-L438

Research output: Contribution to journalArticle

665 Scopus citations
1999
66 Scopus citations

Overexpression of protein kinase C β(II) induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis

Murray, N. R., Davidson, L. A., Chapkin, R. S., Gustafson, W. C., Schattenberg, D. G. & Fields, A. P., May 17 1999, In : Journal of Cell Biology. 145, 4, p. 699-711 13 p.

Research output: Contribution to journalArticle

145 Scopus citations

Protein kinase Cα regulates human monocyte O2̇ production and low density lipoprotein lipid oxidation

Li, Q., Subbulakshmi, V., Fields, A. P., Murray, N. R. & Cathcart, M. K., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3764-3771 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Protein kinase Cι activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis

Jamieson, L., Carpenter, L., Biden, T. J. & Fields, A. P., Feb 12 1999, In : Journal of Biological Chemistry. 274, 7, p. 3927-3930 4 p.

Research output: Contribution to journalArticle

96 Scopus citations
1998

Mapping of a molecular determinant for protein kinase C β(II) isozyme function

Gökmen-Polar, Y. & Fields, A. P., Aug 7 1998, In : Journal of Biological Chemistry. 273, 32, p. 20261-20266 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Phosphatidylglycerol is a physiologic activator of nuclear protein kinase C

Murray, N. R. & Fields, A. P., May 8 1998, In : Journal of Biological Chemistry. 273, 19, p. 11514-11520 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

Pituitary expression of protein kinase C isotypes during early development

Korytko, A. I., Fields, A. P., Allshouse, L. A. & Cuttler, L., Aug 1 1998, In : Journal of Neuroendocrinology. 10, 8, p. 569-576 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
1997

A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transition

Sun, B., Murray, N. R. & Fields, A. P., Oct 17 1997, In : Journal of Biological Chemistry. 272, 42, p. 26313-26317 5 p.

Research output: Contribution to journalArticle

104 Scopus citations

Atypical protein kinase C ι protects human leukemia cells against drug- induced apoptosis

Murray, N. R. & Fields, A. P., Oct 31 1997, In : Journal of Biological Chemistry. 272, 44, p. 27521-27524 4 p.

Research output: Contribution to journalArticle

151 Scopus citations

Identification of protein phosphatase 1 as a mitotic lamin phosphatase

Thompson, L. J., Bollen, M. & Fields, A. P., Nov 21 1997, In : Journal of Biological Chemistry. 272, 47, p. 29693-29697 5 p.

Research output: Contribution to journalArticle

61 Scopus citations

Nuclear phosphatidylinositol-specific hhospholipase c is involved in the g2/m phase transition

Fields, A. P. & Sun, B., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1353

Research output: Contribution to journalArticle

Phosphatidylglycerol is a novel activator of nuclear protein kinase

Murray, C. N. R. & Fields, A. P., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1349

Research output: Contribution to journalArticle

Protein kinase C-mediated interphase lamin B phosphorylation and solubilization

Collas, P., Thompson, L., Fields, A. P., Poccia, D. L. & Courvalin, J. C., Aug 22 1997, In : Journal of Biological Chemistry. 272, 34, p. 21274-21280 7 p.

Research output: Contribution to journalArticle

53 Scopus citations
1996

βIIprotein kinase C is required for the G2/M phase transition of cell cycle

Thompson, L. J. & Fields, A. P., Jan 1 1996, In : Journal of Biological Chemistry. 271, 25, p. 15045-15053 9 p.

Research output: Contribution to journalArticle

Open Access
127 Scopus citations