• 6586 Citations
  • 49 Scopus h-Index
1984 …2021
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Research Output 1984 2018

  • 6586 Citations
  • 49 Scopus h-Index
  • 118 Article
  • 1 Comment/debate
  • 1 Short survey
  • 1 Review article
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Article
2018

Functional Modulation of Gene Expression by Ultraconserved Long Non-coding RNA TUC338 during Growth of Human Hepatocellular Carcinoma

Wen, H. J., Walsh, M. P., Yan, I. K., Takahashi, K., Fields, A. P. & Patel, T. C., Apr 27 2018, In : Food Science and Human Wellness. 2, p. 210-220 11 p.

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
human growth
hepatoma
Hepatocellular Carcinoma
cell growth

Protein kinase Cι: A versatile oncogene in the lung

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Oncology. e1190886.

Research output: Contribution to journalArticle

Oncogenes
Protein Kinase C
Lung
Neoplastic Stem Cells
Phenotype
2017
31 Citations (Scopus)

Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma

Justilien, V., Ali, S. A., Jamieson, L., Yin, N., Cox, A. D., Der, C. J., Murray, N. R. & Fields, A. P., Feb 13 2017, In : Cancer Cell. 31, 2, p. 256-269 14 p.

Research output: Contribution to journalArticle

Epithelial Cells
Ribosomal DNA
Guanine Nucleotide Exchange Factors
Carcinogenesis
Protein Kinase C
2 Citations (Scopus)

Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC

Justilien, V., Lewis, K. C., Murray, N. R. & Fields, A. P., Jun 30 2017, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Epithelial Cells
Squamous Cell Carcinoma
rho GTP-Binding Proteins
Ribosomes
2016
3 Citations (Scopus)

A proof-of-concept trial of protein kinase C iota inhibition with auranofin for the paclitaxel-induced acute pain syndrome

Jatoi, A., Grudem, M. E., Dockter, T. J., Block, M. S., Villasboas Bisneto, J. J. C. ., Tan, A., Deering, E., Kasi, P. M., Mansfield, A., Botero, J. P., Okuno, S. H., Smith, D. R. & Fields, A. P., Nov 12 2016, (Accepted/In press) In : Supportive Care in Cancer. p. 1-6 6 p.

Research output: Contribution to journalArticle

Auranofin
Acute Pain
Paclitaxel
Pain
Area Under Curve
13 Citations (Scopus)

PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis

Wang, Y., Justilien, V., Brennan, K. I., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 20 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Protein Kinase C
Carcinogenesis
Carcinoma
Growth
30 Citations (Scopus)

Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

Ali, S. A., Justilien, V., Jamieson, L., Murray, N. R. & Fields, A. P., Mar 14 2016, In : Cancer Cell. 29, 3, p. 367-378 12 p.

Research output: Contribution to journalArticle

Protein Kinase C
Phenotype
Asymmetric Cell Division
Adenocarcinoma of lung
Neoplastic Stem Cells
15 Citations (Scopus)

Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model

Riabov, V., Yin, S., Song, B., Avdic, A., Schledzewski, K., Ovsiy, I., Gratchev, A., Verdiell, M. L., Sticht, C., Schmuttermaier, C., Schönhaber, H., Weiss, C., Fields, A. P., Simon-Keller, K., Pfister, F., Berlit, S., Marx, A., Arnold, B., Goerdt, S. & Kzhyshkowska, J., May 24 2016, In : Oncotarget. 7, 21, p. 31097-31110 14 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Breast
Breast Neoplasms
Growth
Macrophages

Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jun 30 2016, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.

Research output: Contribution to journalArticle

Protein Kinases
Protein Kinase C
Drug Combinations
Tumors
Lung Neoplasms
18 Citations (Scopus)

The chromosome 3q26 OncCassette: A multigenic driver of human cancer

Fields, A. P., Justilien, V. & Murray, N. R., Jan 1 2016, In : Advances in Biological Regulation. 60, p. 47-63 17 p.

Research output: Contribution to journalArticle

Chromosomes
Genes
Neoplasms
Squamous Cell Carcinoma
Lung
2015
18 Citations (Scopus)

A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion

Butler, A. M., Scotti Buzhardt, M. L., Erdogan, E., Li, S., Inman, K. S., Fields, A. P. & Murray, N. R., 2015, In : Oncotarget. 6, 17, p. 15297-15310 14 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Growth
Gold Sodium Thiomalate
PKC-3 protein
protein kinase C lambda
32 Citations (Scopus)

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

Liou, G. Y., Döppler, H., Braun, U. B., Panayiotou, R., Scotti Buzhardt, M., Radisky, D. C., Crawford, H. C., Fields, A. P., Murray, N. R., Wang, Q. J., Leitges, M. & Storz, P., Feb 20 2015, In : Nature Communications. 6, 6200.

Research output: Contribution to journalArticle

Acinar Cells
Metaplasia
Epidermal Growth Factor Receptor
progressions
Protein Kinases
2014
17 Citations (Scopus)

A Mixed-Methods Feasibility Trial of Protein Kinase C Iota Inhibition with Auranofin in Asymptomatic Ovarian Cancer Patients

Jatoi, A., Radecki Breitkopf, C., Foster, N. R., Block, M. S., Grudem, M., Wahner Hendrickson, A. E., Carlson, R. E., Barrette, B., Karlin, N. & Fields, A. P., Dec 6 2014, (Accepted/In press) In : Oncology (Switzerland). p. 208-213 6 p.

Research output: Contribution to journalArticle

Auranofin
Ovarian Neoplasms
Interviews
protein kinase C lambda
Feasibility Studies
50 Citations (Scopus)

Atypical Protein Kinase Cι as a human oncogene and therapeutic target

Parker, P. J., Justilien, V., Riou, P., Linch, M. & Fields, A. P., Mar 1 2014, In : Biochemical Pharmacology. 88, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Oncogenes
Protein Kinase C
Isoenzymes
Phosphorylation
Neoplasms
14 Citations (Scopus)

Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis

Hill, K. S., Erdogan, E., Khoor, A., Walsh, M. P., Leitges, M., Murray, N. R. & Fields, A. P., Apr 17 2014, In : Oncogene. 33, 16, p. 2134-2144 11 p.

Research output: Contribution to journalArticle

Protein Kinase C-alpha
p38 Mitogen-Activated Protein Kinases
Protein Kinase C
Alveolar Epithelial Cells
Lung
148 Citations (Scopus)

The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma

Justilien, V., Walsh, M. P., Ali, S. A., Thompson, E. A., Murray, N. R. & Fields, A. P., Feb 10 2014, In : Cancer Cell. 25, 2, p. 139-151 13 p.

Research output: Contribution to journalArticle

Acyltransferases
Oncogenes
Protein Kinase C
Squamous Cell Carcinoma
Lung
2013
7 Citations (Scopus)

Atypical protein kinase Ci is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated Dishevelled 2

Greer, Y. E., Fields, A. P., Brown, A. M. C. & Rubin, J. S., Mar 29 2013, In : Journal of Biological Chemistry. 288, 13, p. 9438-9446 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Protein Kinases
Neurites
Ewing's Sarcoma
Small Interfering RNA
16 Citations (Scopus)

Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer

Deng, X., Cao, Y., Liu, Y., Li, F., Sambandam, K., Rajaraman, S., Perkins, A. S., Fields, A. P., Hellmich, M. R., Townsend, C. M., Thompson, E. A. & Ko, T. C., Apr 2013, In : Molecular Carcinogenesis. 52, 4, p. 255-264 10 p.

Research output: Contribution to journalArticle

Virus Integration
Oncogene Proteins
Transforming Growth Factors
Colorectal Neoplasms
Colonic Neoplasms
30 Citations (Scopus)
Gold Sodium Thiomalate
Pancreatic Neoplasms
Non-Small Cell Lung Carcinoma
Ovarian Neoplasms
Maximum Tolerated Dose
25 Citations (Scopus)

PKCi maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis

Wang, Y., Hill, K. S. & Fields, A. P., Dec 2013, In : Molecular Cancer Research. 11, 12, p. 1624-1635 12 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Protein Kinases
Carcinogenesis
Phenotype
Neoplasms
22 Citations (Scopus)

Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma

Kikuchi, K., Soundararajan, A., Zarzabal, L. A., Weems, C. R., Nelon, L. D., Hampton, S. T., Michalek, J. E., Rubin, B. P., Fields, A. P. & Keller, C., Jan 17 2013, In : Oncogene. 32, 3, p. 286-295 10 p.

Research output: Contribution to journalArticle

Alveolar Rhabdomyosarcoma
Gold Sodium Thiomalate
Rhabdomyosarcoma
Vincristine
Neoplasms
22 Citations (Scopus)

Protein Kinase C Zeta Regulates Human Pancreatic Cancer Cell Transformed Growth and Invasion through a STAT3-Dependent Mechanism

Butler, A. M., Scotti Buzhardt, M. L., Li, S., Smith, K. E., Fields, A. P. & Murray, N. R., Aug 28 2013, In : PLoS One. 8, 8, e72061.

Research output: Contribution to journalArticle

pancreatic neoplasms
STAT3 Transcription Factor
cell invasion
protein kinase C
Cell growth
6 Citations (Scopus)
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Neoplasms
Therapeutics
Cause of Death
2012
20 Citations (Scopus)

Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι

Sajan, M. P., Nimal, S., Mastorides, S., Acevedo-Duncan, M., Kahn, C. R., Fields, A. P., Braun, U., Leitges, M. & Farese, R. V., Apr 2012, In : Metabolism: Clinical and Experimental. 61, 4, p. 459-469 11 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Protein Kinase C
Rodentia
Obesity
Liver
31 Citations (Scopus)

Deep sequence analysis of non-small cell lung cancer: Integrated analysis of gene expression, alternative splicing, and single nucleotide variations in lung adenocarcinomas with and without oncogenic KRAS mutations

Kalari, K. R., Rossell, D., Necela, B. M., Asmann, Y., Nair, A., Baheti, S., Kachergus, J. M., Younkin, C. S., Baker, T., Carr, J. M., Tang, X., Walsh, M. P., Chai, H. S., Sun, Z. D., Hart, S., Leontovich, A. A., Hossain, A., Kocher, J-P., Perez, E. A., Reisman, D. N. & 2 others, Fields, A. P. & Thompson, E. A., 2012, In : Frontiers in Oncology. 2, FEB, 00012.

Research output: Contribution to journalArticle

Alternative Splicing
Non-Small Cell Lung Carcinoma
Sequence Analysis
Nucleotides
Gene Expression
37 Citations (Scopus)
Matrix Metalloproteinase 10
Tissue Inhibitor of Metalloproteinases
Tissue Inhibitor of Metalloproteinase-2
Tissue Inhibitor of Metalloproteinase-1
Matrix Metalloproteinases
51 Citations (Scopus)

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential

Justilien, V., Regala, R. P., Tseng, I. C., Walsh, M. P., Batra, J., Radisky, E. S., Murray, N. R. & Fields, A. P., Apr 24 2012, In : PLoS One. 7, 4, e35040.

Research output: Contribution to journalArticle

stromelysin 2
Matrix Metalloproteinase 10
Neoplastic Stem Cells
lung neoplasms
Stem cells
59 Citations (Scopus)

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression

Stallings-Mann, M. L., Waldmann, J., Zhang, Y., Miller, E., Gauthier, M. L., Visscher, D. W., Downey, G. P., Radisky, E. S., Fields, A. P. & Radisky, D. C., Jul 11 2012, In : Science Translational Medicine. 4, 142, 142ra95.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Matrix Metalloproteinases
Lung Neoplasms
Transgenic Mice
Epithelial Cells
11 Citations (Scopus)

Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia

Scotti, M. L., Smith, K. E., Butler, A. M., Calcagno, S. R., Crawford, H. C., Leitges, M., Fields, A. P. & Murray, N. R., Feb 16 2012, In : PLoS One. 7, 2, e30509.

Research output: Contribution to journalArticle

metaplasia
Metaplasia
protein kinase C
transforming growth factor alpha
Transforming Growth Factor alpha
2011
22 Citations (Scopus)

Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation

Regala, R. P., Justilien, V., Walsh, M. P., Weems, C., Khoor, A., Murray, N. R. & Fields, A. P., Oct 17 2011, In : PLoS One. 6, 10, e26439.

Research output: Contribution to journalArticle

stromelysin 2
Matrix Metalloproteinase 10
Alveolar Epithelial Cells
lung neoplasms
Stem cells
45 Citations (Scopus)

Oncogenic activity of Ect2 is regulated through protein kinase Cι-mediated phosphorylation

Justilien, V., Jameison, L., Der, C. J., Rossman, K. L. & Fields, A. P., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8149-8157 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Non-Small Cell Lung Carcinoma
Protein Kinase C
RNA Interference
Guanine Nucleotide Exchange Factors
12 Citations (Scopus)

Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis

Calcagno, S. R., Li, S., Shahid, M. W., Wallace, M. B., Leitges, M., Fields, A. P. & Murray, N. R., Aug 2011, In : Inflammatory Bowel Diseases. 17, 8, p. 1685-1697 13 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Colitis
Intestinal Mucosa
Wound Healing
Homeostasis
33 Citations (Scopus)

Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1)

O'Neill, A. K., Gallegos, L. L., Justilien, V., Garcia, E. L., Leitges, M., Fields, A. P., Hall, R. A. & Newton, A. C., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43559-43568 10 p.

Research output: Contribution to journalArticle

Protein Kinase C
Cell Movement
Substrates
Phosphorylation
Scaffolds
69 Citations (Scopus)

Protein kinase Cι expression and oncogenic signaling mechanisms in cancer

Murray, N. R., Kalari, K. R. & Fields, A. P., Apr 2011, In : Journal of Cellular Physiology. 226, 4, p. 879-887 9 p.

Research output: Contribution to journalArticle

Gold Sodium Thiomalate
Protein Kinase C
Tumors
Stem cells
Oncogenes
2010
58 Citations (Scopus)

Protein kinase Cι is required for pancreatic cancer cell transformed growth and tumorigenesis

Scotti, M. L., Bamlet, W. R., Smyrk, T. C., Fields, A. P. & Murray, N. R., Mar 1 2010, In : Cancer Research. 70, 5, p. 2064-2074 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Protein Kinase C
Carcinogenesis
Growth
Neoplasm Metastasis
39 Citations (Scopus)

Splice variants of SmgGDS control small gtpase prenylation and membrane localization

Berg, T. J., Gastonguay, A. J., Lorimer, E. L., Kuhnmuench, J. R., Li, R., Fields, A. P. & Williams, C. L., Nov 12 2010, In : Journal of Biological Chemistry. 285, 46, p. 35255-35266 12 p.

Research output: Contribution to journalArticle

Prenylation
Monomeric GTP-Binding Proteins
GTP Phosphohydrolases
Membranes
Guanine Nucleotides
58 Citations (Scopus)

The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer

Fields, A. P. & Justilien, V., 2010, In : Advances in Enzyme Regulation. 50, 1, p. 190-200 11 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins
Neoplastic Cell Transformation
Guanine Nucleotide Exchange Factors
RNA Interference
Tumor Cell Line
2009
67 Citations (Scopus)

Atypical protein kinase Cι is required for bronchioalveolar stem cell expansion and lung tumorigenesis

Regala, R. P., Davis, R. K., Kunz, A., Khoor, A., Leitges, M. & Fields, A. P., Oct 1 2009, In : Cancer Research. 69, 19, p. 7603-7611 9 p.

Research output: Contribution to journalArticle

Protein Kinase C
Gold Sodium Thiomalate
Carcinogenesis
Stem Cells
Lung
80 Citations (Scopus)

Ect2 links the PKC-Par6α complex to Rac1 activation and cellular transformation

Justilien, V. & Fields, A. P., Oct 15 2009, In : Oncogene. 28, 41, p. 3597-3607 11 p.

Research output: Contribution to journalArticle

Protein Kinase C
Epithelial Cells
Non-Small Cell Lung Carcinoma
RNA Interference
Guanine Nucleotide Exchange Factors
20 Citations (Scopus)

Meta-analysis of oncogenic protein kinase Cι signaling in lung adenocarcinoma

Erdogan, E., Klee, E. W., Thompson, E. A. & Fields, A. P., Mar 1 2009, In : Clinical Cancer Research. 15, 5, p. 1527-1533 7 p.

Research output: Contribution to journalArticle

Protein Kinase C
Meta-Analysis
Genes
Gene Expression
RNA Interference
31 Citations (Scopus)

Protein kinase C βII and PKCι/λ: Collaborating partners in colon cancer promotion and progression

Murray, N. R., Weems, J., Braun, U., Leitges, M. & Fields, A. P., Jan 15 2009, In : Cancer Research. 69, 2, p. 656-662 7 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Protein Kinases
Protein Kinase C
Colon
Carcinogenesis
19 Citations (Scopus)

Protein kinase cβ is an effective target for chemoprevention of colon cancer

Fields, A. P., Calcagno, S. R., Krishna, M., Rak, S., Leitges, M. & Murray, N. R., Feb 15 2009, In : Cancer Research. 69, 4, p. 1643-1650 8 p.

Research output: Contribution to journalArticle

Chemoprevention
Colonic Neoplasms
Protein Kinases
Catenins
Colon
2008
57 Citations (Scopus)

Atypical protein kinase Cι expression and aurothiomalate sensitivity in human lung cancer cells

Regala, R. P., Thompson, E. A. & Fields, A. P., Jul 15 2008, In : Cancer Research. 68, 14, p. 5888-5895 8 p.

Research output: Contribution to journalArticle

Gold Sodium Thiomalate
Lung Neoplasms
gemcitabine
PKC-3 protein
Thioredoxin Reductase 2
62 Citations (Scopus)

Matrix metalloproteinase-10 is a critical effector of protein kinase Cι-Par6α-mediated lung cancer

Frederick, L. A., Matthews, J. A., Jamieson, L., Justilien, V., Thompson, E. A., Radisky, D. C. & Fields, A. P., Aug 14 2008, In : Oncogene. 27, 35, p. 4841-4853 13 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 10
Protein Kinase C
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Growth
43 Citations (Scopus)

Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon

Calcagno, S. R., Li, S., Colon, M., Kreinest, P. A., Thompson, E. A., Fields, A. P. & Murray, N. R., Jun 1 2008, In : International Journal of Cancer. 122, 11, p. 2462-2470 9 p.

Research output: Contribution to journalArticle

Colon
Carcinogenesis
Aberrant Crypt Foci
Azoxymethane
Colonic Neoplasms
29 Citations (Scopus)

Protein kinase C isozymes as therapeutic targets for treatment of human cancers

Fields, A. P. & Murray, N. R., 2008, In : Advances in Enzyme Regulation. 48, 1, p. 166-178 13 p.

Research output: Contribution to journalArticle

Protein Kinase C
Isoenzymes
Oncogenes
Neoplasms
Genes
12 Citations (Scopus)
Azoxymethane
PPAR gamma
Colon
Neoplasms
Peroxisome Proliferator-Activated Receptors
2007
44 Citations (Scopus)

Differential expression, distribution, and function of PPAR-γ in the proximal and distal colon

Su, W., Bush, C. R., Necela, B. M., Calcagno, S. R., Murray, N. R., Fields, A. P. & Thompson, E. A., Aug 20 2007, In : Physiological Genomics. 30, 3, p. 342-353 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Colon
Epithelial Cells
Genes
Signal Transduction

Erratum: Aurothiomalate inhibits transformed growth by targeting the PB1 domain of atypical protein kinase Cι (Journal of Biological Chemistry (2006) 281, (28450-28459))

Erdogan, E., Lamark, T., Stallings-Mann, M., Jamieson, L., Pellecchia, M., Thompson, E. A., Johansen, T. & Fields, A. P., Mar 30 2007, In : Journal of Biological Chemistry. 282, 13, p. 10132 1 p.

Research output: Contribution to journalArticle

Gold Sodium Thiomalate
Protein Kinases
Growth