• 6902 Citations
  • 50 Scopus h-Index
1984 …2020

Research output per year

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Research Output

2020

Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma

Liu, Y., Yin, N., Wang, X., Khoor, A., Sambandam, V., Ghosh, A. B., Fields, Z. A., Murray, N. R., Justilien, V. & Fields, A. P., Jan 21 2020, In : Cell reports. 30, 3, p. 771-782.e6

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
1 Scopus citations

Protein kinase Cι promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells

Justilien, V., Lewis, K. C., Meneses, K. M., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 12 2020, In : The Journal of biological chemistry. 295, 24, p. 8214-8226 13 p.

Research output: Contribution to journalArticle

2019
Open Access

Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC

Justilien, V., Lewis, K. C., Murray, N. R. & Fields, A. P., Sep 3 2019, In : Small GTPases. 10, 5, p. 388-394 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma

Yin, N., Liu, Y., Khoor, A., Wang, X., Thompson, E. A., Leitges, M., Justilien, V., Weems, C., Murray, N. R. & Fields, A. P., Aug 12 2019, In : Cancer cell. 36, 2, p. 156-167.e7

Research output: Contribution to journalArticle

3 Scopus citations
2018

Functional Modulation of Gene Expression by Ultraconserved Long Non-coding RNA TUC338 during Growth of Human Hepatocellular Carcinoma

Wen, H. J., Walsh, M. P., Yan, I. K., Takahashi, K., Fields, A. & Patel, T., Apr 27 2018, In : iScience. 2, p. 210-220 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Protein kinase Cι: A versatile oncogene in the lung

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Oncology. e1190886.

Research output: Contribution to journalArticle

2017

Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma

Justilien, V., Ali, S. A., Jamieson, L., Yin, N., Cox, A. D., Der, C. J., Murray, N. R. & Fields, A. P., Feb 13 2017, In : Cancer Cell. 31, 2, p. 256-269 14 p.

Research output: Contribution to journalArticle

46 Scopus citations
2016

A proof-of-concept trial of protein kinase C iota inhibition with auranofin for the paclitaxel-induced acute pain syndrome

Jatoi, A., Grudem, M. E., Dockter, T. J., Block, M. S., Villasboas Bisneto, J. J. C. ., Tan, A., Deering, E., Kasi, P. M., Mansfield, A., Botero, J. P., Okuno, S. H., Smith, D. R. & Fields, A. P., Nov 12 2016, (Accepted/In press) In : Supportive Care in Cancer. p. 1-6 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Oncogenic PKCι decides tumor-initiating cell fate

Fields, A. P., Ali, S. A. & Murray, N. R., Sep 16 2016, In : Cell Cycle. 15, 18, p. 2383-2384 2 p.

Research output: Contribution to journalComment/debate

PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis

Wang, Y., Justilien, V., Brennan, K. I., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 20 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

20 Scopus citations

Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

Ali, S. A., Justilien, V., Jamieson, L., Murray, N. R. & Fields, A. P., Mar 14 2016, In : Cancer Cell. 29, 3, p. 367-378 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse

Murray, N. R., Justilien, V. & Fields, A. P., Oct 10 2016, In : Cancer Cell. 30, 4, p. 505-507 3 p.

Research output: Contribution to journalShort survey

6 Scopus citations

Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model

Riabov, V., Yin, S., Song, B., Avdic, A., Schledzewski, K., Ovsiy, I., Gratchev, A., Verdiell, M. L., Sticht, C., Schmuttermaier, C., Schönhaber, H., Weiss, C., Fields, A. P., Simon-Keller, K., Pfister, F., Berlit, S., Marx, A., Arnold, B., Goerdt, S. & Kzhyshkowska, J., May 24 2016, In : Oncotarget. 7, 21, p. 31097-31110 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jun 30 2016, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

The chromosome 3q26 OncCassette: A multigenic driver of human cancer

Fields, A. P., Justilien, V. & Murray, N. R., Jan 1 2016, In : Advances in Biological Regulation. 60, p. 47-63 17 p.

Research output: Contribution to journalArticle

28 Scopus citations
2015

A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion

Butler, A. M., Scotti Buzhardt, M. L., Erdogan, E., Li, S., Inman, K. S., Fields, A. P. & Murray, N. R., 2015, In : Oncotarget. 6, 17, p. 15297-15310 14 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations
74 Scopus citations

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

Liou, G. Y., Döppler, H., Braun, U. B., Panayiotou, R., Scotti Buzhardt, M., Radisky, D. C., Crawford, H. C., Fields, A. P., Murray, N. R., Wang, Q. J., Leitges, M. & Storz, P., Feb 20 2015, In : Nature communications. 6, 6200.

Research output: Contribution to journalArticle

36 Scopus citations
2014

A Mixed-Methods Feasibility Trial of Protein Kinase C Iota Inhibition with Auranofin in Asymptomatic Ovarian Cancer Patients

Jatoi, A., Radecki Breitkopf, C., Foster, N. R., Block, M. S., Grudem, M., Wahner Hendrickson, A. E., Carlson, R. E., Barrette, B., Karlin, N. & Fields, A. P., Dec 6 2014, (Accepted/In press) In : Oncology (Switzerland). p. 208-213 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Atypical Protein Kinase Cι as a human oncogene and therapeutic target

Parker, P. J., Justilien, V., Riou, P., Linch, M. & Fields, A. P., Mar 1 2014, In : Biochemical Pharmacology. 88, 1, p. 1-11 11 p.

Research output: Contribution to journalComment/debate

57 Scopus citations

Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis

Hill, K. S., Erdogan, E., Khoor, A., Walsh, M. P., Leitges, M., Murray, N. R. & Fields, A. P., Apr 17 2014, In : Oncogene. 33, 16, p. 2134-2144 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma

Justilien, V., Walsh, M. P., Ali, S. A., Thompson, E. A., Murray, N. R. & Fields, A. P., Feb 10 2014, In : Cancer cell. 25, 2, p. 139-151 13 p.

Research output: Contribution to journalArticle

171 Scopus citations
2013

Atypical protein kinase Ci is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated Dishevelled 2

Greer, Y. E., Fields, A. P., Brown, A. M. C. & Rubin, J. S., Mar 29 2013, In : Journal of Biological Chemistry. 288, 13, p. 9438-9446 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer

Deng, X., Cao, Y., Liu, Y., Li, F., Sambandam, K., Rajaraman, S., Perkins, A. S., Fields, A. P., Hellmich, M. R., Townsend, C. M., Thompson, E. A. & Ko, T. C., Apr 1 2013, In : Molecular Carcinogenesis. 52, 4, p. 255-264 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
34 Scopus citations

PKCi maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis

Wang, Y., Hill, K. S. & Fields, A. P., Dec 1 2013, In : Molecular Cancer Research. 11, 12, p. 1624-1635 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma

Kikuchi, K., Soundararajan, A., Zarzabal, L. A., Weems, C. R., Nelon, L. D., Hampton, S. T., Michalek, J. E., Rubin, B. P., Fields, A. P. & Keller, C., Jan 17 2013, In : Oncogene. 32, 3, p. 286-295 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Protein Kinase C Zeta Regulates Human Pancreatic Cancer Cell Transformed Growth and Invasion through a STAT3-Dependent Mechanism

Butler, A. M., Scotti Buzhardt, M. L., Li, S., Smith, K. E., Fields, A. P. & Murray, N. R., Aug 28 2013, In : PloS one. 8, 8, e72061.

Research output: Contribution to journalArticle

24 Scopus citations
7 Scopus citations
2012

Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι

Sajan, M. P., Nimal, S., Mastorides, S., Acevedo-Duncan, M., Kahn, C. R., Fields, A. P., Braun, U., Leitges, M. & Farese, R. V., Apr 1 2012, In : Metabolism: Clinical and Experimental. 61, 4, p. 459-469 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Deep sequence analysis of non-small cell lung cancer: Integrated analysis of gene expression, alternative splicing, and single nucleotide variations in lung adenocarcinomas with and without oncogenic KRAS mutations

Kalari, K. R., Rossell, D., Necela, B. M., Asmann, Y. W., Nair, A., Baheti, S., Kachergus, J. M., Younkin, C. S., Baker, T., Carr, J. M., Tang, X., Walsh, M. P., Chai, H. S., Sun, Z., Hart, S. N., Leontovich, A. A., Hossain, A., Kocher, J. P., Perez, E. A., Reisman, D. N. & 2 others, Fields, A. P. & Thompson, E. A., 2012, In : Frontiers in Oncology. 2, FEB, 00012.

Research output: Contribution to journalArticle

32 Scopus citations
42 Scopus citations

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential

Justilien, V., Regala, R. P., Tseng, I. C., Walsh, M. P., Batra, J., Radisky, E. S., Murray, N. R. & Fields, A. P., Apr 24 2012, In : PloS one. 7, 4, e35040.

Research output: Contribution to journalArticle

59 Scopus citations

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression

Stallings-Mann, M. L., Waldmann, J., Zhang, Y., Miller, E., Gauthier, M. L., Visscher, D. W., Downey, G. P., Radisky, E. S., Fields, A. P. & Radisky, D. C., Jul 11 2012, In : Science translational medicine. 4, 142, 142ra95.

Research output: Contribution to journalArticle

65 Scopus citations

Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia

Scotti, M. L., Smith, K. E., Butler, A. M., Calcagno, S. R., Crawford, H. H., Leitges, M., Fields, A. P. & Murray, N. R., Feb 16 2012, In : PloS one. 7, 2, e30509.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation

Regala, R. P., Justilien, V., Walsh, M. P., Weems, C., Khoor, A., Murray, N. R. & Fields, A. P., Oct 17 2011, In : PloS one. 6, 10, e26439.

Research output: Contribution to journalArticle

24 Scopus citations

Oncogenic activity of Ect2 is regulated through protein kinase Cι-mediated phosphorylation

Justilien, V., Jameison, L., Der, C. J., Rossman, K. L. & Fields, A. P., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8149-8157 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis

Calcagno, S. R., Li, S., Shahid, M. W., Wallace, M. B., Leitges, M., Fields, A. P. & Murray, N. R., Aug 1 2011, In : Inflammatory bowel diseases. 17, 8, p. 1685-1697 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1)

O'Neill, A. K., Gallegos, L. L., Justilien, V., Garcia, E. L., Leitges, M., Fields, A. P., Hall, R. A. & Newton, A. C., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43559-43568 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Protein kinase Cι expression and oncogenic signaling mechanisms in cancer

Murray, N. R., Kalari, K. R. & Fields, A. P., Apr 1 2011, In : Journal of Cellular Physiology. 226, 4, p. 879-887 9 p.

Research output: Contribution to journalReview article

77 Scopus citations
2010

Protein kinase Cι is required for pancreatic cancer cell transformed growth and tumorigenesis

Scotti, M. L., Bamlet, W. R., Smyrk, T. C., Fields, A. P. & Murray, N. R., Mar 1 2010, In : Cancer research. 70, 5, p. 2064-2074 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Splice variants of SmgGDS control small gtpase prenylation and membrane localization

Berg, T. J., Gastonguay, A. J., Lorimer, E. L., Kuhnmuench, J. R., Li, R., Fields, A. P. & Williams, C. L., Nov 12 2010, In : Journal of Biological Chemistry. 285, 46, p. 35255-35266 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer

Fields, A. P. & Justilien, V., Aug 18 2010, In : Advances in Enzyme Regulation. 50, 1, p. 190-200 11 p.

Research output: Contribution to journalArticle

69 Scopus citations
2009

Atypical protein kinase Cι is required for bronchioalveolar stem cell expansion and lung tumorigenesis

Regala, R. P., Davis, R. K., Kunz, A., Khoor, A., Leitges, M. & Fields, A. P., Oct 1 2009, In : Cancer research. 69, 19, p. 7603-7611 9 p.

Research output: Contribution to journalArticle

73 Scopus citations

Ect2 links the PKC-Par6α complex to Rac1 activation and cellular transformation

Justilien, V. & Fields, A. P., Oct 15 2009, In : Oncogene. 28, 41, p. 3597-3607 11 p.

Research output: Contribution to journalArticle

88 Scopus citations

Meta-analysis of oncogenic protein kinase Cι signaling in lung adenocarcinoma

Erdogan, E., Klee, E. W., Thompson, E. A. & Fields, A. P., Mar 1 2009, In : Clinical Cancer Research. 15, 5, p. 1527-1533 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Protein kinase C βII and PKCι/λ: Collaborating partners in colon cancer promotion and progression

Murray, N. R., Weems, J., Braun, U., Leitges, M. & Fields, A. P., Jan 15 2009, In : Cancer research. 69, 2, p. 656-662 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Protein kinase cβ is an effective target for chemoprevention of colon cancer

Fields, A. P., Calcagno, S. R., Krishna, M., Rak, S., Leitges, M. & Murray, N. R., Feb 15 2009, In : Cancer research. 69, 4, p. 1643-1650 8 p.

Research output: Contribution to journalArticle

19 Scopus citations