• 5079 Citations
  • 35 Scopus h-Index
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Fingerprint Dive into the research topics where Zhenkun Lou is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 27 Similar Profiles
DNA Damage Medicine & Life Sciences
Double-Stranded DNA Breaks Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
DNA Chemical Compounds
Proteins Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Genomic Instability Medicine & Life Sciences

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Projects 2007 2020

Homologous Recombination
DNA Repair
Breast Neoplasms
Hypoxia-Inducible Factor 1
DNA Damage

Research Output 2000 2019

  • 5079 Citations
  • 35 Scopus h-Index
  • 89 Article
  • 1 Letter
  • 1 Review article

A novel UCHL 3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair

Song, Z., Tu, X., Zhou, Q., Huang, J., Chen, Y., Liu, J., Lee, S. B., Kim, W., Nowsheen, S., Luo, K., Yuan, J. & Lou, Z., Jun 1 2019, In : Cell Death and Disease. 10, 6, 398.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Double-Stranded DNA Breaks
Homologous Recombination
DNA Damage
6 Citations (Scopus)

MRE11 UFMylation promotes ATM activation

Wang, Z., Gong, Y., Peng, B., Shi, R., Fan, D., Zhao, H., Zhu, M., Zhang, H., Lou, Z., Zhou, J., Zhu, W. G., Cong, Y. S. & Xu, X., Jan 1 2019, In : Nucleic acids research. 47, 8, p. 4124-4135 12 p.

Research output: Contribution to journalArticle

Open Access
DNA Damage
Endometrioid Carcinoma
Recombinational DNA Repair
4 Citations (Scopus)

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Tu, X., Qin, B., Zhang, Y., Zhang, C., Kahila, M., Nowsheen, S., Yin, P., Yuan, J., Pei, H., Li, H., Yu, J., Song, Z., Zhou, Q., Zhao, F., Liu, J., Zhang, C., Dong, H. M., Mutter, R. & Lou, Z., Jun 20 2019, In : Molecular Cell. 74, 6, p. 1215-1226.e4

Research output: Contribution to journalArticle

Exosome Multienzyme Ribonuclease Complex
DNA Damage
Drug Therapy
Genetic Therapy
2 Citations (Scopus)

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

Lee, S. B., Kim, J. J., Han, S. A., Fan, Y., Guo, L. S., Aziz, K., Nowsheen, S., Kim, S. S., Park, S. Y., Luo, Q., Chung, J. O., Choi, S. I., Aziz, A., Yin, P., Tong, S. Y., Fiesel, F., Springer, W., Zhang, J. S. & Lou, Z., Aug 1 2019, In : Nature Cell Biology. 21, 8, p. 940-951 12 p.

Research output: Contribution to journalArticle

Receptor-Interacting Protein Serine-Threonine Kinases
AMP-Activated Protein Kinases
Ubiquitin-Protein Ligases
8 Citations (Scopus)

UFL1 promotes histone H4 ufmylation and ATM activation

Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. M. & Lou, Z., Dec 1 2019, In : Nature communications. 10, 1, 1242.

Research output: Contribution to journalArticle

Open Access
Ataxia Telangiectasia
Chemical activation