Projects per year
Fingerprint Dive into the research topics where Zhenkun Lou is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 20 Similar Profiles
DNA Damage
Medicine & Life Sciences
Double-Stranded DNA Breaks
Medicine & Life Sciences
Breast Neoplasms
Medicine & Life Sciences
DNA
Chemical Compounds
Proteins
Medicine & Life Sciences
Phosphorylation
Medicine & Life Sciences
Neoplasms
Medicine & Life Sciences
DNA Repair
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2007 2020
Regulation of homologous recombination and cancer cell response to chemoradiotherapy
12/15/15 → 11/30/20
Project: Research project
Homologous Recombination
Chemoradiotherapy
DNA Repair
Breast Neoplasms
Neoplasms
Oncogenes
Carcinogenesis
Hypoxia-Inducible Factor 1
Up-Regulation
Glycolysis
DNA Damage
Sumoylation
Neoplasms
Ubiquitination
Carcinogenesis
Research Output 2000 2019
A novel UCHL 3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair
Song, Z., Tu, X., Zhou, Q., Huang, J., Chen, Y., Liu, J., Lee, S. B., Kim, W., Nowsheen, S., Luo, K., Yuan, J. & Lou, Z., Jun 1 2019, In : Cell Death and Disease. 10, 6, 398.Research output: Contribution to journal › Article
Open Access
Triple Negative Breast Neoplasms
Double-Stranded DNA Breaks
Homologous Recombination
DNA Damage
Ubiquitination
2
Citations
(Scopus)
PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy
Tu, X., Qin, B., Zhang, Y., Zhang, C., Kahila, M., Nowsheen, S., Yin, P., Yuan, J., Pei, H., Li, H., Yu, J., Song, Z., Zhou, Q., Zhao, F., Liu, J., Zhang, C., Dong, H. M., Mutter, R. & Lou, Z., Jun 20 2019, In : Molecular Cell. 74, 6, p. 1215-1226.e4Research output: Contribution to journal › Article
Exosome Multienzyme Ribonuclease Complex
DNA Damage
Radiation
Drug Therapy
Genetic Therapy
2
Citations
(Scopus)
The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome
Lee, S. B., Kim, J. J., Han, S. A., Fan, Y., Guo, L. S., Aziz, K., Nowsheen, S., Kim, S. S., Park, S. Y., Luo, Q., Chung, J. O., Choi, S. I., Aziz, A., Yin, P., Tong, S. Y., Fiesel, F., Springer, W., Zhang, J. S. & Lou, Z., Aug 1 2019, In : Nature Cell Biology. 21, 8, p. 940-951 12 p.Research output: Contribution to journal › Article
Carcinogenesis
Inflammation
Receptor-Interacting Protein Serine-Threonine Kinases
AMP-Activated Protein Kinases
Ubiquitin-Protein Ligases
2
Citations
(Scopus)
UFL1 promotes histone H4 ufmylation and ATM activation
Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. M. & Lou, Z., Dec 1 2019, In : Nature communications. 10, 1, 1242.Research output: Contribution to journal › Article
Open Access
ataxia
Ataxia Telangiectasia
Ligases
Histones
Chemical activation
USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2
Wu, J., Chen, Y., Geng, G., Li, L., Yin, P., Nowsheen, S., Li, Y., Wu, C., Liu, J., Zhao, F., Kim, W., Zhou, Q., Huang, J., Guo, G., Zhang, C., Tu, X., Gao, X., Lou, Z., Luo, K., Qiao, H. & 1 others, , May 1 2019, In : Cancer Letters. 449, p. 114-124 11 p.Research output: Contribution to journal › Article
Checkpoint Kinase 2
DNA Damage
Radiation
Apoptosis
Protein-Serine-Threonine Kinases