• 4766 Citations
  • 33 Scopus h-Index
20002020
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Fingerprint Dive into the research topics where Zhenkun Lou is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 20 Similar Profiles
DNA Damage Medicine & Life Sciences
Double-Stranded DNA Breaks Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
DNA Chemical Compounds
Proteins Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
DNA Repair Medicine & Life Sciences

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Projects 2007 2020

Homologous Recombination
Chemoradiotherapy
DNA Repair
Breast Neoplasms
Neoplasms
Oncogenes
Carcinogenesis
Hypoxia-Inducible Factor 1
Up-Regulation
Glycolysis
DNA Damage
Sumoylation
Neoplasms
Ubiquitination
Carcinogenesis

Research Output 2000 2019

  • 4766 Citations
  • 33 Scopus h-Index
  • 86 Article
  • 1 Letter
  • 1 Review article

A novel UCHL 3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair

Song, Z., Tu, X., Zhou, Q., Huang, J., Chen, Y., Liu, J., Lee, S. B., Kim, W., Nowsheen, S., Luo, K., Yuan, J. & Lou, Z., Jun 1 2019, In : Cell Death and Disease. 10, 6, 398.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Double-Stranded DNA Breaks
Homologous Recombination
DNA Damage
Ubiquitination

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Tu, X., Qin, B., Zhang, Y., Zhang, C., Kahila, M., Nowsheen, S., Yin, P., Yuan, J., Pei, H., Li, H., Yu, J., Song, Z., Zhou, Q., Zhao, F., Liu, J., Zhang, C., Dong, H. M., Mutter, R. & Lou, Z., Jun 20 2019, In : Molecular Cell. 74, 6, p. 1215-1226.e4

Research output: Contribution to journalArticle

Exosome Multienzyme Ribonuclease Complex
DNA Damage
Radiation
Drug Therapy
Genetic Therapy
1 Citation (Scopus)

UFL1 promotes histone H4 ufmylation and ATM activation

Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. M. & Lou, Z., Dec 1 2019, In : Nature communications. 10, 1, 1242.

Research output: Contribution to journalArticle

Open Access
ataxia
Ataxia Telangiectasia
Ligases
Histones
Chemical activation

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2

Wu, J., Chen, Y., Geng, G., Li, L., Yin, P., Nowsheen, S., Li, Y., Wu, C., Liu, J., Zhao, F., Kim, W., Zhou, Q., Huang, J., Guo, G., Zhang, C., Tu, X., Gao, X., Lou, Z., Luo, K., Qiao, H. & 1 othersYuan, J., May 1 2019, In : Cancer Letters. 449, p. 114-124 11 p.

Research output: Contribution to journalArticle

Checkpoint Kinase 2
DNA Damage
Radiation
Apoptosis
Protein-Serine-Threonine Kinases
3 Citations (Scopus)
Chromatin
Cell Differentiation
Nucleosomes
Genes
Histone Chaperones