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Zhenkun Lou, PhD

Professor

  • 4604 Citations
  • 33 h-Index
20002020
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Neoplasms Medicine & Life Sciences
DNA Repair Medicine & Life Sciences

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Projects 2007 2020

Regulation of homologous recombination and cancer cell response to chemoradiotherapy

Lou, Z.

National Institutes of Health

12/15/15 → 11/30/20

Project: Research project

Homologous Recombination
Chemoradiotherapy
DNA Repair
Breast Neoplasms
Neoplasms

The Role of WSB1 in Tumorigenesis

Lou, Z.

National Institutes of Health

9/1/14 → 8/31/19

Project: Research project

Oncogenes
Carcinogenesis
Hypoxia-Inducible Factor 1
Up-Regulation
Glycolysis

Regulation of Necroptosis and inflammation

Lou, Z.

Project: Research project

UFM1 signaling in DNA damage response and cancer therapy

Lou, Z.

Project: Research project

Regultion of p53 Deubiquitination

Lou, Z.

National Institutes of Health

1/1/11 → 3/31/16

Project: Research project

DNA Damage
Sumoylation
Neoplasms
Ubiquitination
Carcinogenesis

Research Output 2000 2019

  • 4604 Citations
  • 33 h-Index
  • 84 Article
  • 1 Letter
  • 1 Review article

UFL1 promotes histone H4 ufmylation and ATM activation

Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. M. & Lou, Z., Dec 1 2019, In : Nature communications. 10, 1, 1242.

Research output: Contribution to journal › Article

Open Access
ataxia
Ataxia Telangiectasia
enzyme activity
Enzyme activity
Ligases

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2

Wu, J., Chen, Y., Geng, G., Li, L., Yin, P., Nowsheen, S., Li, Y., Wu, C., Liu, J., Zhao, F., Kim, W., Zhou, Q., Huang, J., Guo, G., Zhang, C., Tu, X., Gao, X., Lou, Z., Luo, K., Qiao, H. & 1 othersYuan, J., May 1 2019, In : Cancer Letters. 449, p. 114-124 11 p.

Research output: Contribution to journal › Article

Checkpoint Kinase 2
DNA Damage
Radiation
Apoptosis
Protein-Serine-Threonine Kinases
2 Citations (Scopus)

Asf1a resolves bivalent chromatin domains for the induction of lineage-specific genes during mouse embryonic stem cell differentiation

Gao, Y., Gan, H., Lou, Z. & Zhang, Z., Jul 3 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 27, p. E6162-E6171

Research output: Contribution to journal › Article

Chromatin
Cell Differentiation
Nucleosomes
Genes
Histone Chaperones
1 Citation (Scopus)

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular Cancer Therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journal › Article

Triple Negative Breast Neoplasms
Radiotherapy
Exome
Homologous Recombination
Neoplasms
6 Citations (Scopus)

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye-Agyeman, F., Gonsalves, W., Lou, Z., Karnitz, L. M., Goetz, M. P. & Hitosugi, T. D., Feb 6 2018, In : Cell Reports. 22, 6, p. 1365-1373 9 p.

Research output: Contribution to journal › Article

Carnitine O-Palmitoyltransferase
Lysine
Phosphopyruvate Hydratase
Isotope Labeling
Mutation