• 5016 Citations
  • 34 Scopus h-Index
20002020
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Research Output 2000 2019

  • 5016 Citations
  • 34 Scopus h-Index
  • 88 Article
  • 1 Letter
  • 1 Review article
2019

A novel UCHL 3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair

Song, Z., Tu, X., Zhou, Q., Huang, J., Chen, Y., Liu, J., Lee, S. B., Kim, W., Nowsheen, S., Luo, K., Yuan, J. & Lou, Z., Jun 1 2019, In : Cell Death and Disease. 10, 6, 398.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Double-Stranded DNA Breaks
Homologous Recombination
DNA Damage
Ubiquitination
5 Citations (Scopus)

MRE11 UFMylation promotes ATM activation

Wang, Z., Gong, Y., Peng, B., Shi, R., Fan, D., Zhao, H., Zhu, M., Zhang, H., Lou, Z., Zhou, J., Zhu, W. G., Cong, Y. S. & Xu, X., Jan 1 2019, In : Nucleic acids research. 47, 8, p. 4124-4135 12 p.

Research output: Contribution to journalArticle

Open Access
DNA Damage
Ubiquitins
Genome
Endometrioid Carcinoma
Recombinational DNA Repair
3 Citations (Scopus)

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Tu, X., Qin, B., Zhang, Y., Zhang, C., Kahila, M., Nowsheen, S., Yin, P., Yuan, J., Pei, H., Li, H., Yu, J., Song, Z., Zhou, Q., Zhao, F., Liu, J., Zhang, C., Dong, H. M., Mutter, R. & Lou, Z., Jun 20 2019, In : Molecular Cell. 74, 6, p. 1215-1226.e4

Research output: Contribution to journalArticle

Exosome Multienzyme Ribonuclease Complex
DNA Damage
Radiation
Drug Therapy
Genetic Therapy
2 Citations (Scopus)

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

Lee, S. B., Kim, J. J., Han, S. A., Fan, Y., Guo, L. S., Aziz, K., Nowsheen, S., Kim, S. S., Park, S. Y., Luo, Q., Chung, J. O., Choi, S. I., Aziz, A., Yin, P., Tong, S. Y., Fiesel, F., Springer, W., Zhang, J. S. & Lou, Z., Aug 1 2019, In : Nature Cell Biology. 21, 8, p. 940-951 12 p.

Research output: Contribution to journalArticle

Carcinogenesis
Inflammation
Receptor-Interacting Protein Serine-Threonine Kinases
AMP-Activated Protein Kinases
Ubiquitin-Protein Ligases
6 Citations (Scopus)

UFL1 promotes histone H4 ufmylation and ATM activation

Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. M. & Lou, Z., Dec 1 2019, In : Nature communications. 10, 1, 1242.

Research output: Contribution to journalArticle

Open Access
ataxia
Ataxia Telangiectasia
Ligases
Histones
Chemical activation
2 Citations (Scopus)

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2

Wu, J., Chen, Y., Geng, G., Li, L., Yin, P., Nowsheen, S., Li, Y., Wu, C., Liu, J., Zhao, F., Kim, W., Zhou, Q., Huang, J., Guo, G., Zhang, C., Tu, X., Gao, X., Lou, Z., Luo, K., Qiao, H. & 1 others, Yuan, J., May 1 2019, In : Cancer Letters. 449, p. 114-124 11 p.

Research output: Contribution to journalArticle

Checkpoint Kinase 2
DNA Damage
Radiation
Apoptosis
Protein-Serine-Threonine Kinases
2018
4 Citations (Scopus)
Chromatin
Cell Differentiation
Nucleosomes
Genes
Histone Chaperones
3 Citations (Scopus)

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular Cancer Therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Radiotherapy
Exome
Homologous Recombination
Neoplasms
10 Citations (Scopus)

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye-Agyeman, F., Gonsalves, W., Lou, Z., Karnitz, L. M., Goetz, M. P. & Hitosugi, T. D., Feb 6 2018, In : Cell Reports. 22, 6, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

Carnitine O-Palmitoyltransferase
Lysine
Phosphopyruvate Hydratase
Isotope Labeling
Mutation
2 Citations (Scopus)

Chk1 inhibitor SCH 900776 enhances the antitumor activity of MLN4924 on pancreatic cancer

Li, J. A., Song, C., Rong, Y., Kuang, T., Wang, D., Xu, X., Yuan, J., Luo, K., Qin, B., Nowsheen, S., Lou, Z. & Lou, W., Jan 1 2018, (Accepted/In press) In : Cell Cycle. p. 1-9 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
DNA Damage
Cullin Proteins
Proteasome Endopeptidase Complex
Enzymes
13 Citations (Scopus)

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Yu, J., Qin, B., Moyer, A., Nowsheen, S., Liu, T., Qin, S., Zhuang, Y., Liu, D., Lu, S. W., Kalari, K. R., Visscher, D. W., Copland, J. A. III., McLaughlin, S. A., Moreno Aspitia, A., Northfelt, D. W., Gray, R. J., Lou, Z., Suman, V. J., Weinshilboum, R. M., Boughey, J. C. & 2 others, Goetz, M. P. & Wang, L. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2376-2388 13 p.

Research output: Contribution to journalArticle

decitabine
Triple Negative Breast Neoplasms
Methyltransferases
DNA
Biomarkers

Erratum to: Topoisomerase IIα controls the decatenation checkpoint (Nature Cell Biology, (2009), 11, 2, (204-210), 10.1038/ncb1828)

Luo, K., Yuan, J., Chen, J. & Lou, Z., Jan 1 2018, (Accepted/In press) In : Nature Cell Biology.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Cell Biology
Molecular Biology
4 Citations (Scopus)

H2AFX and MDC1 promote maintenance of genomic integrity in male germ cells

Testa, E., Nardozi, D., Antinozzi, C., Faieta, M., Di Cecca, S., Caggiano, C., Fukuda, T., Bonanno, E., Lou, Z., Maldonado, A., Roig, I., Di Giacomo, M. & Barchi, M., Mar 1 2018, In : Journal of Cell Science. 131, 6, jcs214411.

Research output: Contribution to journalReview article

Chromosome Pairing
Germ Cells
Maintenance
Chromosomes
Genetic Recombination
17 Citations (Scopus)

L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage

Nowsheen, S., Aziz, K., Aziz, A., Deng, M., Qin, B., Luo, K., Jeganathan, K. B., Zhang, H., Liu, T., Yu, J., Deng, Y., Yuan, J., Ding, W. D., Van Deursen, J. & Lou, Z., Apr 1 2018, In : Nature Cell Biology. 20, 4, p. 455-464 10 p.

Research output: Contribution to journalArticle

Ubiquitin
Brain Neoplasms
DNA Damage
Double-Stranded DNA Breaks
Proteins
16 Citations (Scopus)

The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization

Li, L., Liu, T., Li, Y., Wu, C., Luo, K., Yin, Y., Chen, Y., Nowsheen, S., Wu, J., Lou, Z. & Yuan, J., Feb 16 2018, (Accepted/In press) In : Oncogene. p. 1-10 10 p.

Research output: Contribution to journalArticle

Cell Survival
Neoplasms
Proteins
Breast Neoplasms
Deubiquitinating Enzymes
4 Citations (Scopus)

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

Kurmi, K., Hitosugi, S., Yu, J., Boakye-Agyeman, F., Wiese, E. K., Larson, T. R., Dai, Q., Machida, Y., Lou, Z., Wang, L. M., Boughey, J. C., Kaufmann, S. H., Goetz, M. P., Karnitz, L. M. & Hitosugi, T. D., Dec 4 2018, In : Cell Metabolism. 28, 6, p. 833-847.e8

Research output: Contribution to journalArticle

Mitochondrial Form Creatine Kinase
Phosphocreatine
Tyrosine
Phosphorylation
Breast Neoplasms
7 Citations (Scopus)

USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization

Wu, C., Luo, K., Zhao, F., Yin, P., Song, Y., Deng, M., Huang, J., Chen, Y., Li, L., Lee, S. B., Kim, J. J., Zhou, Q., Tu, X., Nowsheen, S., Luo, Q., Gao, X., Lou, Z., Liu, Z. & Yuan, J., Jun 4 2018, (Accepted/In press) In : Cell Death and Differentiation. p. 1-15 15 p.

Research output: Contribution to journalArticle

Catenins
Carcinogenesis
Wnt Signaling Pathway
Neoplasms
Biological Phenomena
3 Citations (Scopus)

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Nowsheen, S., Aziz, K., Luo, K., Deng, M., Qin, B., Yuan, J., Jeganathan, K. B., Yu, J., Zhang, H., Ding, W. D., Van Deursen, J. & Lou, Z., Dec 1 2018, In : Nature Communications. 9, 1, 2736.

Research output: Contribution to journalArticle

positive feedback
DNA Damage
deoxyribonucleic acid
damage
Feedback
2017
53 Citations (Scopus)

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J. Y., Rajman, L. A., Qin, B., Lou, Z., Gorbunova, V., Aravind, L., Steegborn, C. & Sinclair, D. A., Mar 24 2017, In : Science. 355, 6331, p. 1312-1317 6 p.

Research output: Contribution to journalArticle

NAD
Proteins
DNA Repair
Protein Interaction Domains and Motifs
Breast Neoplasms
41 Citations (Scopus)

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

Liu, T., Yu, J., Deng, M., Yin, Y., Zhang, H., Luo, K., Qin, B., Li, Y., Wu, C., Ren, T., Han, Y., Yin, P., Kim, J. J., Lee, S. B., Lin, J., Zhang, L., Zhang, J., Nowsheen, S., Wang, L. M., Boughey, J. C. & 3 others, Goetz, M. P., Yuan, J. & Lou, Z., Jan 9 2017, In : Nature Communications. 8, 13923.

Research output: Contribution to journalArticle

metastasis
Tumors
breast
cancer
Chemical activation
11 Citations (Scopus)

Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study

Yu, J., Qin, B., Moyer, A., Sinnwell, J. P., Thompson, K. J., Copland, J. A. III., Marlow, L. A., Miller, J. L., Yin, P., Gao, B., Minter-Dykhouse, K., Tang, X., McLaughlin, S. A., Moreno Aspitia, A., Schweitzer, A., Lu, Y., Hubbard, J., Northfelt, D. W., Gray, R. J., Hunt, K. & 10 others, Conners, A. L., Suman, V. J., Kalari, K. R., Ingle, J. N., Lou, Z., Visscher, D. W., Weinshilboum, R. M., Boughey, J. C., Goetz, M. P. & Wang, L. M., Dec 6 2017, In : Breast cancer research : BCR. 19, 1, 1 p.

Research output: Contribution to journalArticle

Heterografts
Breast Neoplasms
Biopsy
Drug Therapy
Neoplasms
18 Citations (Scopus)

Regulation of Serine-Threonine Kinase Akt Activation by NAD+-Dependent Deacetylase SIRT7

Yu, J., Qin, B., Wu, F., Qin, S., Nowsheen, S., Shan, S., Zayas, J., Pei, H., Lou, Z. & Wang, L. M., Jan 31 2017, In : Cell Reports. 18, 5, p. 1229-1240 12 p.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
NAD
Lysine
Cell Survival
Chemical activation
16 Citations (Scopus)

USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response

Li, Y., Luo, K., Yin, Y., Wu, C., Deng, M., Li, L., Chen, Y., Nowsheen, S., Lou, Z. & Yuan, J., Jun 1 2017, In : Nature Communications. 8, 15752.

Research output: Contribution to journalArticle

BRCA1 Protein
DNA Damage
deoxyribonucleic acid
damage
proteins
21 Citations (Scopus)

USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling

Luo, K., Li, Y., Yin, Y., Li, L., Wu, C., Chen, Y., Nowsheen, S., Hu, Q., Zhang, L., Lou, Z. & Yuan, J., May 15 2017, In : EMBO Journal. 36, 10, p. 1434-1446 13 p.

Research output: Contribution to journalArticle

Cell proliferation
gemcitabine
Pancreatic Neoplasms
Carcinogenesis
Immunophilins
2016
41 Citations (Scopus)

A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice

Zhang, H., Liu, H., Chen, Y., Yang, X., Wang, P., Liu, T., Deng, M., Qin, B., Correia, C., Lee, S., Kim, J., Sparks, M., Nair, A. A., Evans, D. L., Kalari, K. R., Zhang, P., Wang, L. M., You, Z., Kaufmann, S. H., Lou, Z. & 1 others, Pei, H., Jan 5 2016, In : Nature Communications. 7, 10201.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
Homologous Recombination
S Phase
strands
Cell Cycle
18 Citations (Scopus)

A phosphorylation–deubiquitination cascade regulates the BRCA2–RAD51 axis in homologous recombination

Luo, K., Li, L., Li, Y., Wu, C., Yin, Y., Chen, Y., Deng, M., Nowsheen, S., Yuan, J. & Lou, Z., Dec 1 2016, In : Genes and Development. 30, 23, p. 2581-2595 15 p.

Research output: Contribution to journalArticle

Homologous Recombination
Rad51 Recombinase
Genomic Instability
Ubiquitination
DNA Repair
34 Citations (Scopus)

Deubiquitination and Activation of AMPK by USP10

Deng, M., Yang, X., Qin, B., Liu, T., Zhang, H., Guo, W., Lee, S. B., Kim, J. J., Yuan, J., Pei, H., Wang, L. M. & Lou, Z., Feb 18 2016, In : Molecular Cell. 61, 4, p. 614-624 11 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Phosphorylation
Ubiquitination
Homeostasis
Threonine
25 Citations (Scopus)

Failure to detect DNA-guided genome editing using Natronobacterium gregoryi Argonaute

Lee, S. H., Turchiano, G., Ata, H., Nowsheen, S., Romito, M., Lou, Z., Ryu, S. M., Ekker, S. C., Cathomen, T. & Kim, J. S., Nov 28 2016, In : Nature Biotechnology. 35, 1, p. 17-18 2 p.

Research output: Contribution to journalLetter

Natronobacterium
DNA
Genes
Gene Editing
15 Citations (Scopus)

HEATR1 negatively regulates akt to help sensitize pancreatic cancer cells to chemotherapy

Liu, T., Fang, Y., Zhang, H., Deng, M., Gao, B., Niu, N., Yu, J., Lee, S. B., Kim, J. J., Qin, B., Xie, F., Evans, D., Wang, L. M., Lou, W. & Lou, Z., Feb 1 2016, In : Cancer Research. 76, 3, p. 572-581 10 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Drug Therapy
Adenocarcinoma
Proteins
7 Citations (Scopus)

MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication

Evans, D. L., Zhang, H., Ham, H., Pei, H., Lee, S. B., Kim, J. J., Billadeau, D. D. & Lou, Z., Jan 1 2016, In : Cell Cycle. 15, 1, p. 95-105 11 p.

Research output: Contribution to journalArticle

DNA Replication
Cell Cycle
Replication Origin
S Phase
Origin Recognition Complex
19 Citations (Scopus)

Multiple-level validation identifies PARK2 in the development of lung cancer and chronic obstructive pulmonary disease

Lee, S. B., She, J., Deng, B., Kim, J. J., De Andrade, M., Na, J., Sun, Z. D., Wampfler, J. A., Cunningham, J. M., Wu, Y., Limper, A. H., Aubry, M. C., Wendt, C., Biterman, P., Yang, P. & Lou, Z., 2016, In : Oncotarget. 7, 28, p. 44211-44223 13 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Lung Neoplasms
Genomic Instability
Inflammation
Chromosomal Instability
23 Citations (Scopus)

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response

Wang, Z., Zhang, H., Liu, J., Cheruiyot, A., Lee, J. H., Ordog, T., Lou, Z., You, Z. & Zhang, Z., Apr 15 2016, In : Genes and Development. 30, 8, p. 946-959 14 p.

Research output: Contribution to journalArticle

DNA Damage
Enzymes
DNA Breaks
Genomic Instability
Ubiquitination
3 Citations (Scopus)

WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation

Kim, J. J., Lee, S. B., Yi, S. Y., Han, S. A., Kim, S. H., Lee, J. M., Tong, S. Y., Yin, P., Gao, B., Zhang, J. & Lou, Z., Dec 13 2016, (Accepted/In press) In : Cell Research.

Research output: Contribution to journalArticle

Oncogenes
Carcinogenesis
Cell Proliferation
Neoplasms
Ubiquitin-Protein Ligases
2015
1 Citation (Scopus)

Bora downregulation results in radioresistance by promoting repair of double strand breaks

Cairns, J., Peng, Y., Yee, V. C., Lou, Z. & Wang, L. M., Mar 5 2015, In : PLoS One. 10, 3, e0119208.

Research output: Contribution to journalArticle

radiation resistance
Repair
Down-Regulation
irradiation
Phosphorylation
12 Citations (Scopus)

CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase

Luo, K., Deng, M., Li, Y., Wu, C., Xu, Z., Yuan, J. & Lou, Z., Apr 23 2015, In : Nucleic Acids Research. 43, 11, p. 5465-5475 11 p.

Research output: Contribution to journalArticle

Homologous Recombination
S Phase
Phosphorylation
Cell Cycle
Recombinational DNA Repair
29 Citations (Scopus)

DBC1 functions as a tumor suppressor by regulating p53 stability

Qin, B., Minter-Dykhouse, K., Yu, J., Zhang, J., Liu, T., Zhang, H., Lee, S. B., Kim, J. J., Wang, L. M. & Lou, Z., Mar 3 2015, In : Cell Reports. 10, 8, p. 1324-1334 11 p.

Research output: Contribution to journalArticle

Tumors
Breast Neoplasms
Neoplasms
Knockout Mice
Genes
30 Citations (Scopus)

Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1

Gao, Y., Tang, J., Chen, W., Li, Q., Nie, J., Lin, F., Wu, Q., Chen, Z., Gao, Z., Fan, H., Tsun, A., Shen, J., Chen, G., Liu, Z., Lou, Z., Olsen, N. J., Zheng, S. G. & Li, B., Jun 23 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 25, p. E3246-E3254

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Breast Neoplasms
Inflammation
Autoimmune Experimental Encephalomyelitis
Colitis
23 Citations (Scopus)

KAP1 deacetylation by SIRT1 promotes non-homologous end-joining repair

Lin, Y. H., Yuan, J., Pei, H., Liu, T., Ann, D. K. & Lou, Z., Apr 23 2015, In : PLoS One. 10, 4, e0123935.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
Homologous Recombination
homologous recombination
Sequence Homology
DNA repair
29 Citations (Scopus)

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1

Lee, S. B., Kim, J. J., Nam, H. J., Gao, B., Yin, P., Qin, B., Yi, S. Y., Ham, H., Evans, D., Kim, S. H., Zhang, J., Deng, M., Liu, T., Zhang, H., Billadeau, D. D., Wang, L. M., Giaime, E., Shen, J., Pang, Y-P., Jen, J. & 2 others, Van Deursen, J. & Lou, Z., Feb 19 2015, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

Genomic Instability
Mitosis
Anaphase-Promoting Complex-Cyclosome
Ubiquitin-Protein Ligases
Carcinogenesis
43 Citations (Scopus)

The efficacy of the wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma

Pokorny, J. L., Calligaris, D., Gupta, S. K., Iyekegbe, D. O., Mueller, D., Bakken, K. K., Carlson, B. L., Schroeder, M. A., Evans, D. L., Lou, Z., Decker, P. A., Eckel-Passow, J. E., Pucci, V., Ma, B., Shumway, S. D., Elmquist, W. F., Agar, N. Y. R. & Sarkaria, J. N., Apr 15 2015, In : Clinical Cancer Research. 21, 8, p. 1916-1924 9 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Blood-Brain Barrier
Heterografts
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
16 Citations (Scopus)

WSB1 promotes tumor metastasis by inducing pVHL degradation

Kim, J. J., Lee, S. B., Jang, J., Yi, S. Y., Kim, S. H., Han, S. A., Lee, J. M., Tong, S. Y., Vincelette, N. D., Gao, B., Yin, P., Evans, D., Choi, D. W., Qin, B., Liu, T., Zhang, H., Deng, M., Jen, J., Zhang, J., Wang, L. M. & 1 others, Lou, Z., Nov 1 2015, In : Genes and Development. 29, 21, p. 2244-2257 14 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Ubiquitin-Protein Ligases
Neoplasms
Neoplasm Genes
Ubiquitination
2014
24 Citations (Scopus)

A Divergent Role of the SIRT1-TopBP1 Axis in Regulating Metabolic Checkpoint and DNA Damage Checkpoint

Liu, T., Lin, Y. H., Leng, W., Jung, S., Zhang, H., Deng, M., Evans, D., Li, Y., Luo, K., Qin, B., Qin, J., Yuan, J. & Lou, Z., Dec 4 2014, In : Molecular Cell. 56, 5, p. 681-695 15 p.

Research output: Contribution to journalArticle

DNA Damage
DNA Replication
Acetylation
Physiological Stress
Glucose
41 Citations (Scopus)

AMPK regulates histone H2B O-GlcNAcylation

Xu, Q., Yang, C., Du, Y., Chen, Y., Liu, H., Deng, M., Zhang, H., Zhang, L., Liu, T., Liu, Q., Wang, L. M., Lou, Z. & Pei, H., 2014, In : Nucleic Acids Research. 42, 9, p. 5594-5604 11 p.

Research output: Contribution to journalArticle

Adenosine Monophosphate
Histones
Protein Kinases
Chromatin
Genes
9 Citations (Scopus)

ATM increases activation-induced cytidine deaminase activity at downstream s regions during class-switch recombination

Khair, L., Guikema, J. E. J., Linehan, E. K., Ucher, A. J., Leus, N. G. J., Ogilvie, C., Lou, Z., Schrader, C. E. & Stavnezer, J., May 15 2014, In : Journal of Immunology. 192, 10, p. 4887-4896 10 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Genetic Recombination
DNA Damage
B-Lymphocytes
Recombinational DNA Repair
33 Citations (Scopus)

HERC2-USP20 axis regulates DNA damage checkpoint through Claspin

Yuan, J., Luo, K., Deng, M., Li, Y., Yin, P., Gao, B., Fang, Y., Wu, P., Liu, T. & Lou, Z., Dec 1 2014, In : Nucleic Acids Research. 42, 21, p. 13110-13121 12 p.

Research output: Contribution to journalArticle

DNA Damage
Ubiquitin-Protein Ligases
Ubiquitination
Post Translational Protein Processing
Cell Cycle Checkpoints
25 Citations (Scopus)

Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks

Wang, Q., Goldstein, M., Alexander, P., Wakeman, T. P., Sun, T., Feng, J., Lou, Z., Kastan, M. B. & Wang, X. F., Apr 16 2014, In : EMBO Journal. 33, 8, p. 862-877 16 p.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
Automatic teller machines
DNA Damage
Phosphorylation
DNA
19 Citations (Scopus)

Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1

Oi, N., Yuan, J., Malakhova, M., Luo, K., Li, Y., Ryu, J., Zhang, L., Bode, A. M., Xu, Z., Li, Y., Lou, Z. & Dong, Z., Jul 7 2014, In : Oncogene. 34, 20, p. 2660-2671 12 p.

Research output: Contribution to journalArticle

ras GTPase-Activating Proteins
src Homology Domains
Carrier Proteins
Ubiquitin-Specific Proteases
Apoptosis
47 Citations (Scopus)

The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation

Hu, G., Lou, Z. & Gupta, M., Sep 8 2014, In : PLoS One. 9, 9, e107016.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Long Noncoding RNA
Eukaryotic Initiation Factors
translation (genetics)
Proto-Oncogene Proteins c-myc
2013
20 Citations (Scopus)

Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein

Qin, B., Gao, B., Yu, J., Yuan, J. & Lou, Z., May 31 2013, In : Journal of Biological Chemistry. 288, 22, p. 16139-16144 6 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
DNA Damage
Chemical activation
DNA
Proteins
63 Citations (Scopus)

Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity

Ham, H., Guerrier, S., Kim, J. J., Schoon, R. A., Anderson, E. L., Hamann, M. J., Lou, Z. & Billadeau, D. D., Apr 1 2013, In : Journal of Immunology. 190, 7, p. 3661-3669 9 p.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome Protein
Talin
Cytokinesis
Natural Killer Cells
Actins