• 5223 Citations
  • 36 Scopus h-Index
20002020

Research output per year

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Research Output

2020

Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

Yu, J., Qin, B. & Lou, Z., Feb 11 2020, In : Cell and Bioscience. 10, 1, 13.

Research output: Contribution to journalReview article

Open Access
2019

A novel UCHL 3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair

Song, Z., Tu, X., Zhou, Q., Huang, J., Chen, Y., Liu, J., Lee, S. B., Kim, W., Nowsheen, S., Luo, K., Yuan, J. & Lou, Z., Jun 1 2019, In : Cell Death and Disease. 10, 6, 398.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

MRE11 UFMylation promotes ATM activation

Wang, Z., Gong, Y., Peng, B., Shi, R., Fan, D., Zhao, H., Zhu, M., Zhang, H., Lou, Z., Zhou, J., Zhu, W. G., Cong, Y. S. & Xu, X., Jan 1 2019, In : Nucleic acids research. 47, 8, p. 4124-4135 12 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Tu, X., Qin, B., Zhang, Y., Zhang, C., Kahila, M., Nowsheen, S., Yin, P., Yuan, J., Pei, H., Li, H., Yu, J., Song, Z., Zhou, Q., Zhao, F., Liu, J., Zhang, C., Dong, H. M., Mutter, R. & Lou, Z., Jun 20 2019, In : Molecular Cell. 74, 6, p. 1215-1226.e4

Research output: Contribution to journalArticle

6 Scopus citations

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

Lee, S. B., Kim, J. J., Han, S. A., Fan, Y., Guo, L. S., Aziz, K., Nowsheen, S., Kim, S. S., Park, S. Y., Luo, Q., Chung, J. O., Choi, S. I., Aziz, A., Yin, P., Tong, S. Y., Fiesel, F., Springer, W., Zhang, J. S. & Lou, Z., Aug 1 2019, In : Nature Cell Biology. 21, 8, p. 940-951 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

UFL1 promotes histone H4 ufmylation and ATM activation

Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. M. & Lou, Z., Dec 1 2019, In : Nature communications. 10, 1, 1242.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2

Wu, J., Chen, Y., Geng, G., Li, L., Yin, P., Nowsheen, S., Li, Y., Wu, C., Liu, J., Zhao, F., Kim, W., Zhou, Q., Huang, J., Guo, G., Zhang, C., Tu, X., Gao, X., Lou, Z., Luo, K., Qiao, H. & 1 others, Yuan, J., May 1 2019, In : Cancer Letters. 449, p. 114-124 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex

Kim, W., Zhao, F., Wu, R., Qin, S., Nowsheen, S., Huang, J., Zhou, Q., Chen, Y., Deng, M., Guo, G., Luo, K., Lou, Z. & Yuan, J., Dec 1 2019, In : Nature communications. 10, 1, 5304.

Research output: Contribution to journalArticle

Open Access
2018
7 Scopus citations

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular Cancer Therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye-Agyeman, F., Gonsalves, W., Lou, Z., Karnitz, L. M., Goetz, M. P. & Hitosugi, T. D., Feb 6 2018, In : Cell Reports. 22, 6, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Chk1 inhibitor SCH 900776 enhances the antitumor activity of MLN4924 on pancreatic cancer

Li, J. A., Song, C., Rong, Y., Kuang, T., Wang, D., Xu, X., Yuan, J., Luo, K., Qin, B., Nowsheen, S., Lou, Z. & Lou, W., Jan 1 2018, (Accepted/In press) In : Cell Cycle. p. 1-9 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Yu, J., Qin, B., Moyer, A., Nowsheen, S., Liu, T., Qin, S., Zhuang, Y., Liu, D., Lu, S. W., Kalari, K. R., Visscher, D. W., Copland, J. A. III., McLaughlin, S. A., Moreno Aspitia, A., Northfelt, D. W., Gray, R. J., Lou, Z., Suman, V. J., Weinshilboum, R. M., Boughey, J. C. & 2 others, Goetz, M. P. & Wang, L. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2376-2388 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Erratum to: Topoisomerase IIα controls the decatenation checkpoint (Nature Cell Biology, (2009), 11, 2, (204-210), 10.1038/ncb1828)

Luo, K., Yuan, J., Chen, J. & Lou, Z., Jan 1 2018, (Accepted/In press) In : Nature Cell Biology.

Research output: Contribution to journalArticle

H2AFX and MDC1 promote maintenance of genomic integrity in male germ cells

Testa, E., Nardozi, D., Antinozzi, C., Faieta, M., Di Cecca, S., Caggiano, C., Fukuda, T., Bonanno, E., Lou, Z., Maldonado, A., Roig, I., Di Giacomo, M. & Barchi, M., Mar 1 2018, In : Journal of Cell Science. 131, 6, jcs214411.

Research output: Contribution to journalReview article

6 Scopus citations

L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage

Nowsheen, S., Aziz, K., Aziz, A., Deng, M., Qin, B., Luo, K., Jeganathan, K. B., Zhang, H., Liu, T., Yu, J., Deng, Y., Yuan, J., Ding, W. D., Van Deursen, J. & Lou, Z., Apr 1 2018, In : Nature Cell Biology. 20, 4, p. 455-464 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization

Li, L., Liu, T., Li, Y., Wu, C., Luo, K., Yin, Y., Chen, Y., Nowsheen, S., Wu, J., Lou, Z. & Yuan, J., Feb 16 2018, (Accepted/In press) In : Oncogene. p. 1-10 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

Kurmi, K., Hitosugi, S., Yu, J., Boakye-Agyeman, F., Wiese, E. K., Larson, T. R., Dai, Q., Machida, Y., Lou, Z., Wang, L. M., Boughey, J. C., Kaufmann, S. H., Goetz, M. P., Karnitz, L. M. & Hitosugi, T. D., Dec 4 2018, In : Cell Metabolism. 28, 6, p. 833-847.e8

Research output: Contribution to journalArticle

6 Scopus citations

USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization

Wu, C., Luo, K., Zhao, F., Yin, P., Song, Y., Deng, M., Huang, J., Chen, Y., Li, L., Lee, S. B., Kim, J. J., Zhou, Q., Tu, X., Nowsheen, S., Luo, Q., Gao, X., Lou, Z., Liu, Z. & Yuan, J., Jun 4 2018, (Accepted/In press) In : Cell Death and Differentiation. p. 1-15 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Nowsheen, S., Aziz, K., Luo, K., Deng, M., Qin, B., Yuan, J., Jeganathan, K. B., Yu, J., Zhang, H., Ding, W. D., Van Deursen, J. & Lou, Z., Dec 1 2018, In : Nature Communications. 9, 1, 2736.

Research output: Contribution to journalArticle

3 Scopus citations
2017

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J. Y., Rajman, L. A., Qin, B., Lou, Z., Gorbunova, V., Aravind, L., Steegborn, C. & Sinclair, D. A., Mar 24 2017, In : Science. 355, 6331, p. 1312-1317 6 p.

Research output: Contribution to journalArticle

62 Scopus citations

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

Liu, T., Yu, J., Deng, M., Yin, Y., Zhang, H., Luo, K., Qin, B., Li, Y., Wu, C., Ren, T., Han, Y., Yin, P., Kim, J. J., Lee, S. B., Lin, J., Zhang, L., Zhang, J., Nowsheen, S., Wang, L. M., Boughey, J. C. & 3 others, Goetz, M. P., Yuan, J. & Lou, Z., Jan 9 2017, In : Nature Communications. 8, 13923.

Research output: Contribution to journalArticle

45 Scopus citations

Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study

Yu, J., Qin, B., Moyer, A., Sinnwell, J. P., Thompson, K. J., Copland, J. A. III., Marlow, L. A., Miller, J. L., Yin, P., Gao, B., Minter-Dykhouse, K., Tang, X., McLaughlin, S. A., Moreno Aspitia, A., Schweitzer, A., Lu, Y., Hubbard, J., Northfelt, D. W., Gray, R. J., Hunt, K. & 10 others, Conners, A. L., Suman, V. J., Kalari, K. R., Ingle, J. N., Lou, Z., Visscher, D. W., Weinshilboum, R. M., Boughey, J. C., Goetz, M. P. & Wang, L. M., Dec 6 2017, In : Breast cancer research : BCR. 19, 1, 1 p.

Research output: Contribution to journalArticle

13 Scopus citations

Regulation of Serine-Threonine Kinase Akt Activation by NAD+-Dependent Deacetylase SIRT7

Yu, J., Qin, B., Wu, F., Qin, S., Nowsheen, S., Shan, S., Zayas, J., Pei, H., Lou, Z. & Wang, L. M., Jan 31 2017, In : Cell Reports. 18, 5, p. 1229-1240 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response

Li, Y., Luo, K., Yin, Y., Wu, C., Deng, M., Li, L., Chen, Y., Nowsheen, S., Lou, Z. & Yuan, J., Jun 1 2017, In : Nature Communications. 8, 15752.

Research output: Contribution to journalArticle

20 Scopus citations

USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling

Luo, K., Li, Y., Yin, Y., Li, L., Wu, C., Chen, Y., Nowsheen, S., Hu, Q., Zhang, L., Lou, Z. & Yuan, J., May 15 2017, In : EMBO Journal. 36, 10, p. 1434-1446 13 p.

Research output: Contribution to journalArticle

24 Scopus citations
2016

A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice

Zhang, H., Liu, H., Chen, Y., Yang, X., Wang, P., Liu, T., Deng, M., Qin, B., Correia, C., Lee, S., Kim, J., Sparks, M., Nair, A. A., Evans, D. L., Kalari, K. R., Zhang, P., Wang, L. M., You, Z., Kaufmann, S. H., Lou, Z. & 1 others, Pei, H., Jan 5 2016, In : Nature Communications. 7, 10201.

Research output: Contribution to journalArticle

46 Scopus citations

A phosphorylation–deubiquitination cascade regulates the BRCA2–RAD51 axis in homologous recombination

Luo, K., Li, L., Li, Y., Wu, C., Yin, Y., Chen, Y., Deng, M., Nowsheen, S., Yuan, J. & Lou, Z., Dec 1 2016, In : Genes and Development. 30, 23, p. 2581-2595 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Deubiquitination and Activation of AMPK by USP10

Deng, M., Yang, X., Qin, B., Liu, T., Zhang, H., Guo, W., Lee, S. B., Kim, J. J., Yuan, J., Pei, H., Wang, L. M. & Lou, Z., Feb 18 2016, In : Molecular Cell. 61, 4, p. 614-624 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Failure to detect DNA-guided genome editing using Natronobacterium gregoryi Argonaute

Lee, S. H., Turchiano, G., Ata, H., Nowsheen, S., Romito, M., Lou, Z., Ryu, S. M., Ekker, S. C., Cathomen, T. & Kim, J. S., Nov 28 2016, In : Nature Biotechnology. 35, 1, p. 17-18 2 p.

Research output: Contribution to journalLetter

27 Scopus citations

HEATR1 negatively regulates akt to help sensitize pancreatic cancer cells to chemotherapy

Liu, T., Fang, Y., Zhang, H., Deng, M., Gao, B., Niu, N., Yu, J., Lee, S. B., Kim, J. J., Qin, B., Xie, F., Evans, D., Wang, L. M., Lou, W. & Lou, Z., Feb 1 2016, In : Cancer Research. 76, 3, p. 572-581 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication

Evans, D. L., Zhang, H., Ham, H., Pei, H., Lee, S. B., Kim, J. J., Billadeau, D. D. & Lou, Z., Jan 1 2016, In : Cell Cycle. 15, 1, p. 95-105 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Multiple-level validation identifies PARK2 in the development of lung cancer and chronic obstructive pulmonary disease

Lee, S. B., She, J., Deng, B., Kim, J. J., De Andrade, M., Na, J., Sun, Z. D., Wampfler, J. A., Cunningham, J. M., Wu, Y., Limper, A. H., Aubry, M. C., Wendt, C., Biterman, P., Yang, P. & Lou, Z., 2016, In : Oncotarget. 7, 28, p. 44211-44223 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response

Wang, Z., Zhang, H., Liu, J., Cheruiyot, A., Lee, J. H., Ordog, T., Lou, Z., You, Z. & Zhang, Z., Apr 15 2016, In : Genes and Development. 30, 8, p. 946-959 14 p.

Research output: Contribution to journalArticle

26 Scopus citations

WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation

Kim, J. J., Lee, S. B., Yi, S. Y., Han, S. A., Kim, S. H., Lee, J. M., Tong, S. Y., Yin, P., Gao, B., Zhang, J. & Lou, Z., Dec 13 2016, (Accepted/In press) In : Cell Research.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Bora downregulation results in radioresistance by promoting repair of double strand breaks

Cairns, J., Peng, Y., Yee, V. C., Lou, Z. & Wang, L. M., Mar 5 2015, In : PLoS One. 10, 3, e0119208.

Research output: Contribution to journalArticle

1 Scopus citations

CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase

Luo, K., Deng, M., Li, Y., Wu, C., Xu, Z., Yuan, J. & Lou, Z., Apr 23 2015, In : Nucleic Acids Research. 43, 11, p. 5465-5475 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

DBC1 functions as a tumor suppressor by regulating p53 stability

Qin, B., Minter-Dykhouse, K., Yu, J., Zhang, J., Liu, T., Zhang, H., Lee, S. B., Kim, J. J., Wang, L. & Lou, Z., Mar 3 2015, In : Cell reports. 10, 8, p. 1324-1334 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1

Gao, Y., Tang, J., Chen, W., Li, Q., Nie, J., Lin, F., Wu, Q., Chen, Z., Gao, Z., Fan, H., Tsun, A., Shen, J., Chen, G., Liu, Z., Lou, Z., Olsen, N. J., Zheng, S. G. & Li, B., Jun 23 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 25, p. E3246-E3254

Research output: Contribution to journalArticle

41 Scopus citations

KAP1 deacetylation by SIRT1 promotes non-homologous end-joining repair

Lin, Y. H., Yuan, J., Pei, H., Liu, T., Ann, D. K. & Lou, Z., Apr 23 2015, In : PLoS One. 10, 4, e0123935.

Research output: Contribution to journalArticle

23 Scopus citations

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1

Lee, S. B., Kim, J. J., Nam, H. J., Gao, B., Yin, P., Qin, B., Yi, S. Y., Ham, H., Evans, D., Kim, S. H., Zhang, J., Deng, M., Liu, T., Zhang, H., Billadeau, D. D., Wang, L. M., Giaime, E., Shen, J., Pang, Y-P., Jen, J. & 2 others, Van Deursen, J. & Lou, Z., Feb 19 2015, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

30 Scopus citations

Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1

Oi, N., Yuan, J., Malakhova, M., Luo, K., Li, Y., Ryu, J., Zhang, L., Bode, A. M., Xu, Z., Li, Y., Lou, Z. & Dong, Z., May 14 2015, In : Oncogene. 34, 20, p. 2660-2671 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

The efficacy of the wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma

Pokorny, J. L., Calligaris, D., Gupta, S. K., Iyekegbe, D. O., Mueller, D., Bakken, K. K., Carlson, B. L., Schroeder, M. A., Evans, D. L., Lou, Z., Decker, P. A., Eckel-Passow, J. E., Pucci, V., Ma, B., Shumway, S. D., Elmquist, W. F., Agar, N. Y. R. & Sarkaria, J. N., Apr 15 2015, In : Clinical Cancer Research. 21, 8, p. 1916-1924 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

WSB1 promotes tumor metastasis by inducing pVHL degradation

Kim, J. J., Lee, S. B., Jang, J., Yi, S. Y., Kim, S. H., Han, S. A., Lee, J. M., Tong, S. Y., Vincelette, N. D., Gao, B., Yin, P., Evans, D., Choi, D. W., Qin, B., Liu, T., Zhang, H., Deng, M., Jen, J., Zhang, J., Wang, L. M. & 1 others, Lou, Z., Nov 1 2015, In : Genes and Development. 29, 21, p. 2244-2257 14 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014

A Divergent Role of the SIRT1-TopBP1 Axis in Regulating Metabolic Checkpoint and DNA Damage Checkpoint

Liu, T., Lin, Y. H., Leng, W., Jung, S. Y., Zhang, H., Deng, M., Evans, D., Li, Y., Luo, K., Qin, B., Qin, J., Yuan, J. & Lou, Z., Dec 4 2014, In : Molecular Cell. 56, 5, p. 681-695 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

AMPK regulates histone H2B O-GlcNAcylation

Xu, Q., Yang, C., Du, Y., Chen, Y., Liu, H., Deng, M., Zhang, H., Zhang, L., Liu, T., Liu, Q., Wang, L., Lou, Z. & Pei, H., May 2014, In : Nucleic acids research. 42, 9, p. 5594-5604 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

ATM increases activation-induced cytidine deaminase activity at downstream s regions during class-switch recombination

Khair, L., Guikema, J. E. J., Linehan, E. K., Ucher, A. J., Leus, N. G. J., Ogilvie, C., Lou, Z., Schrader, C. E. & Stavnezer, J., May 15 2014, In : Journal of Immunology. 192, 10, p. 4887-4896 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

HERC2-USP20 axis regulates DNA damage checkpoint through Claspin

Yuan, J., Luo, K., Deng, M., Li, Y., Yin, P., Gao, B., Fang, Y., Wu, P., Liu, T. & Lou, Z., Dec 1 2014, In : Nucleic Acids Research. 42, 21, p. 13110-13121 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks

Wang, Q., Goldstein, M., Alexander, P., Wakeman, T. P., Sun, T., Feng, J., Lou, Z., Kastan, M. B. & Wang, X. F., Apr 16 2014, In : EMBO Journal. 33, 8, p. 862-877 16 p.

Research output: Contribution to journalArticle

28 Scopus citations

The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation

Hu, G., Lou, Z. & Gupta, M., Sep 8 2014, In : PloS one. 9, 9, e107016.

Research output: Contribution to journalArticle

48 Scopus citations