Yongjie Zhang, PhD

  • 3724 Citations
  • 25 Scopus h-Index
20032019
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Research Output 2003 2019

  • 3724 Citations
  • 25 Scopus h-Index
  • 38 Article
2019
10 Citations (Scopus)

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

Chew, J., Cook, C., Gendron, T. D., Jansen-West, K., Del Rosso, G., Daughrity, L. M., Castanedes-Casey, M., Kurti, A., Stankowski, J. N., Disney, M. D., Rothstein, J. D., Dickson, D. W., Fryer, J. D., Zhang, Y. & Petrucelli, L., Feb 15 2019, In : Molecular neurodegeneration. 14, 1, 1 p.

Research output: Contribution to journalArticle

TDP-43 Proteinopathies
Dipeptides
RNA
Proteins
Antisense RNA
Open Access
Frontotemporal Lobar Degeneration
Neurites
Inclusion Bodies
Mutation
Blood Vessels
16 Citations (Scopus)

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

Zhang, Y. J., Guo, L., Gonzales, P. K., Gendron, T. F., Wu, Y., Jansen-West, K., O’Raw, A. D., Pickles, S. R., Prudencio, M., Carlomagno, Y., Gachechiladze, M. A., Ludwig, C., Tian, R., Chew, J., DeTure, M., Lin, W. L., Tong, J., Daughrity, L. M., Yue, M., Song, Y. & 15 others, Andersen, J. W., Castanedes-Casey, M., Kurti, A., Datta, A., Antognetti, G., McCampbell, A., Rademakers, R., Oskarsson, B., Dickson, D. W., Kampmann, M., Ward, M. E., Fryer, J. D., Link, C. D., Shorter, J. & Petrucelli, L., Feb 15 2019, In : Science. 363, 6428, eaav2606.

Research output: Contribution to journalArticle

Double-Stranded RNA
Heterochromatin
Proline
Arginine
Proteins
13 Citations (Scopus)

The Hairpin Form of r(G 4 C 2 ) exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules

Wang, Z. F., Ursu, A., Childs-Disney, J. L., Guertler, R., Yang, W. Y., Bernat, V., Rzuczek, S. G., Fuerst, R., Zhang, Y., Gendron, T. D., Yildirim, I., Dwyer, B. G., Rice, J. E., Petrucelli, L. & Disney, M. D., Feb 21 2019, In : Cell Chemical Biology. 26, 2, p. 179-190.e12

Research output: Contribution to journalArticle

Frontotemporal Dementia
RNA-Binding Proteins
Toxicity
RNA
G-Quadruplexes
2018
46 Citations (Scopus)

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Zhang, Y., Gendron, T. D., Ebbert, M. T. W., O’Raw, A. D., Yue, M., Jansen-West, K., Zhang, X., Prudencio, M., Chew, J., Cook, C., Daughrity, L. M., Tong, J., Song, Y., Pickles, S. R., Castanedes-Casey, M., Kurti, A., Rademakers, R. V., Oskarsson, B., Dickson, D. W., Hu, W. & 3 others, Gitler, A. D., Fryer, J. D. & Petrucelli, L., Jun 25 2018, (Accepted/In press) In : Nature Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Protein Biosynthesis
Dipeptides
Proteins
Brain
17 Citations (Scopus)
Open Access
Frontotemporal Lobar Degeneration
Dipeptides
Brain Diseases
Motor Neuron Disease
Polymers
81 Citations (Scopus)

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

Chou, C. C., Zhang, Y., Umoh, M. E., Vaughan, S. W., Lorenzini, I., Liu, F., Sayegh, M., Donlin-Asp, P. G., Chen, Y. H., Duong, D. M., Seyfried, N. T., Powers, M. A., Kukar, T., Hales, C. M., Gearing, M., Cairns, N. J., Boylan, K. B., Dickson, D. W., Rademakers, R. V., Zhang, Y. & 5 others, Petrucelli, L., Sattler, R., Zarnescu, D. C., Glass, J. D. & Rossol, W., Feb 1 2018, In : Nature Neuroscience. 21, 2, p. 228-239 12 p.

Research output: Contribution to journalArticle

Nuclear Pore
Cell Nucleus Active Transport
DNA-Binding Proteins
Pathology
Nuclear Pore Complex Proteins
2017
52 Citations (Scopus)

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

Gendron, T. D., Chew, J., Stankowski, J. N., Hayes, L. R., Zhang, Y., Prudencio, M., Carlomagno, Y., Daughrity, L. M., Jansen-West, K., Perkerson, E. A., O'Raw, A., Cook, C., Pregent, L., Belzil, V., Van Blitterswijk, M., Tabassian, L. J., Lee, C. W., Yue, M., Tong, J., Song, Y. & 59 others, Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Rademakers, R. V., Fryer, J. D., Rush, B. K., Pedraza, O. D., Caputo, A. M., Desaro, P., Palmucci, C., Robertson, A., Heckman, M. G., Diehl, N. N., Wiggs, E., Tierney, M., Braun, L., Farren, J., Lacomis, D., Ladha, S., Fournier, C. N., McCluskey, L. F., Elman, L. B., Toledo, J. B., McBride, J. D., Tiloca, C., Morelli, C., Poletti, B., Solca, F., Prelle, A., Wuu, J., Jockel-Balsarotti, J., Rigo, F., Ambrose, C., Datta, A., Yang, W., Raitcheva, D., Antognetti, G., McCampbell, A., Van Swieten, J. C., Miller, B. L., Boxer, A. L., Brown, R. H., Bowser, R., Miller, T. M., Trojanowski, J. Q., Grossman, M., Berry, J. D., Hu, W. T., Ratti, A., Traynor, B. J., Disney, M. D., Benatar, M., Silani, V., Glass, J. D., Floeter, M. K., Rothstein, J. D., Boylan, K. B. & Petrucelli, L., Mar 29 2017, In : Science Translational Medicine. 9, 383, eaai7866.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
RNA
Proteins
Antisense Oligonucleotides
Therapeutics
25 Citations (Scopus)

Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients

Prudencio, M., Gonzales, P. K., Cook, C., Gendron, T. D., Daughrity, L. M., Song, Y., Ebbert, M. T. W., Van Blitterswijk, M., Zhang, Y., Jansen-West, K., Baker, M. C., Deture, M., Rademakers, R. V., Boylan, K. B., Dickson, D. W., Petrucelli, L. & Link, C. D., Sep 1 2017, In : Human Molecular Genetics. 26, 17, p. 3421-3431 11 p.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Amyotrophic Lateral Sclerosis
Brain
RNA Polymerase II
RNA Sequence Analysis
2016
110 Citations (Scopus)

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Zhang, Y., Gendron, T. D., Grima, J. C., Sasaguri, H., Jansen-West, K., Xu, Y. F., Katzman, R. B., Gass, J., Murray, M. E., Shinohara, M., Lin, W. L., Garrett, A., Stankowski, J. N., Daughrity, L., Tong, J., Perkerson, E. A., Yue, M., Chew, J., Castanedes-Casey, M., Kurti, A. & 16 others, Wang, Z. S., Liesinger, A. M., Baker, J. D., Jiang, J., Lagier-Tourenne, C., Edbauer, D., Cleveland, D. W., Rademakers, R. V., Boylan, K. B., Bu, G. D., Link, C. D., Dickey, C. A., Rothstein, J. D., Dickson, D. W., Fryer, J. D. & Petrucelli, L., May 1 2016, In : Nature Neuroscience. 19, 5, p. 668-677 10 p.

Research output: Contribution to journalArticle

Nucleocytoplasmic Transport Proteins
Cell Nucleus Active Transport
Pathology
Ubiquitinated Proteins
Xeroderma Pigmentosum
49 Citations (Scopus)

Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts

Kramer, N. J., Carlomagno, Y., Zhang, Y., Almeida, S., Cook, C., Gendron, T. D., Prudencio, M., Van Blitterswijk, M., Belzil, V., Couthouis, J., Paul, J. W., Goodman, L. D., Daughrity, L., Chew, J., Garrett, A., Pregent, L., Jansen-West, K., Tabassian, L. J., Rademakers, R. V., Boylan, K. & 16 others, Graff Radford, N. R., Josephs, K. A., Parisi, J. E., Knopman, D. S., Petersen, R. C., Boeve, B. F., Deng, N., Feng, Y., Cheng, T. H., Dickson, D. W., Cohen, S. N., Bonini, N. M., Link, C. D., Gao, F. B., Petrucelli, L. & Gitler, A. D., Aug 12 2016, In : Science. 353, 6300, p. 708-712 5 p.

Research output: Contribution to journalArticle

Dipeptides
Peptide Elongation Factors
Antisense RNA
Transcription Factors
Animal Models
15 Citations (Scopus)

The extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivo

Sasaguri, H., Chew, J., Xu, Y. F., Gendron, T. D., Garrett, A., Lee, C. W., Jansen-West, K., Bauer, P. O., Perkerson, E. A., Tong, J., Stetler, C. & Zhang, Y., Feb 25 2016, (Accepted/In press) In : Brain Research.

Research output: Contribution to journalArticle

Tars
DNA-Binding Proteins
Nuclear Localization Signals
Neurons
Mutation
2015
171 Citations (Scopus)

C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

Chew, J., Gendron, T. D., Prudencio, M., Sasaguri, H., Zhang, Y., Castanedes-Casey, M., Lee, C. W., Jansen-West, K., Kurti, A., Murray, M. E., Bieniek, K. F., Bauer, P. O., Whitelaw, E. C., Rousseau, L., Stankowski, J. N., Stetler, C., Daughrity, L. M., Perkerson, E. A., Desaro, P., Johnston, A. & 7 others, Overstreet, K., Edbauer, D., Rademakers, R. V., Boylan, K. B., Dickson, D. W., Fryer, J. D. & Petrucelli, L., Jun 5 2015, In : Science. 348, 6239, p. 1151-1154 4 p.

Research output: Contribution to journalArticle

Pathology
Brain
glycylproline
Animal Disease Models
Nuclear RNA
104 Citations (Scopus)

Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

Peters, O. M., Cabrera, G. T., Tran, H., Gendron, T. D., McKeon, J. E., Metterville, J., Weiss, A., Wightman, N., Salameh, J., Kim, J., Sun, H., Boylan, K. B., Dickson, D. W., Kennedy, Z., Lin, Z., Zhang, Y., Daughrity, L., Jung, C., Gao, F. B., Sapp, P. C. & 7 others, Horvitz, H. R., Bosco, D. A., Brown, S. P., de Jong, P., Petrucelli, L., Mueller, C. & Brown, R. H., Dec 2 2015, In : Neuron. 88, 5, p. 902-909 8 p.

Research output: Contribution to journalArticle

Dipeptides
Transgenic Mice
RNA
Bacterial Artificial Chromosomes
Antisense RNA
2014
151 Citations (Scopus)

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

Zhang, Y., Jansen-West, K., Xu, Y. F., Gendron, T. D., Bieniek, K. F., Lin, W. L., Sasaguri, H., Caulfield, T., Hubbard, J., Daughrity, L., Chew, J., Belzil, V., Prudencio, M., Stankowski, J. N., Castanedes-Casey, M., Whitelaw, E., Ash, P. E. A., Deture, M., Rademakers, R. V., Boylan, K. B. & 2 others, Dickson, D. W. & Petrucelli, L., 2014, In : Acta Neuropathologica. 128, 4, p. 505-524 20 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Proteins
Proteasome Endopeptidase Complex
Caspase 3
Endoplasmic Reticulum
20 Citations (Scopus)

Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins

Carlomagno, Y., Zhang, Y., Davis, M., Lin, W. L., Cook, C., Dunmore, J., Tay, W., Menkosky, K., Cao, X., Petrucelli, L. & Deture, M., Mar 4 2014, In : PLoS One. 9, 3, e90452.

Research output: Contribution to journalArticle

Casein Kinase II
Heat-Shock Proteins
heat shock proteins
Polymerization
polymerization
168 Citations (Scopus)

Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS

Su, Z., Zhang, Y., Gendron, T. D., Bauer, P. O., Chew, J., Yang, W. Y., Fostvedt, E., Jansen-West, K., Belzil, V., Desaro, P., Johnston, A., Overstreet, K., Oh, S. Y., Todd, P. K., Berry, J. D., Cudkowicz, M. E., Boeve, B. F., Dickson, D. W., Floeter, M., Traynor, B. J. & 9 others, Morelli, C., Ratti, A., Silani, V., Rademakers, R. V., Brown, R. H., Rothstein, J. D., Boylan, K. B., Petrucelli, L. & Disney, M. D., Sep 3 2014, In : Neuron. 83, 5, p. 1043-1050 8 p.

Research output: Contribution to journalArticle

Biomarkers
Proteins
Poisons
Cerebrospinal Fluid
Cultured Cells
8 Citations (Scopus)

Errata to Discovery of a biomarker and lead small molecules to target r(GGGGCC)-Associated Defects in c9FTD/ALS [Neuron, 83, (2014) 1043-1050]

Su, Z., Zhang, Y., Gendron, T. D., Bauer, P. O., Chew, J., Yang, W. Y., Fostvedt, E., Jansen-West, K., Belzil, V., Desaro, P., Johnston, A., Overstreet, K., Oh, S. Y., Todd, P. K., Berry, J. D., Cudkowicz, M. E., Boeve, B. F., Dickson, D. W., Floeter, M. K., Traynor, B. J. & 9 others, Morelli, C., Ratti, A., Silani, V., Rademakers, R. V., Brown, R. H., Rothstein, J. D., Boylan, K. B., Petrucelli, L. & Disney, M. D., Oct 1 2014, In : Neuron. 84, 1, p. 239 1 p.

Research output: Contribution to journalArticle

Biomarkers
Neurons
88 Citations (Scopus)

Mechanisms of toxicity in C9FTLD/ALS

Gendron, T. D., Belzil, V., Zhang, Y. & Petrucelli, L., Mar 2014, In : Acta Neuropathologica. 127, 3, p. 359-376 18 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
RNA-Binding Proteins
Frontotemporal Lobar Degeneration
RNA
Epigenomics
39 Citations (Scopus)

Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency

Lee, W. C., Almeida, S., Prudencio, M., Caulfield, T., Zhang, Y., Tay, W. M., Bauer, P. O., Chew, J., Sasaguri, H., Jansen-west, K. R., Gendron, T. D., Stetler, C. T., Finch, N., Mackenzie, I. R., Rademakers, R. V., Gao, F. B. & Petrucelli, L., Mar 2014, In : Human Molecular Genetics. 23, 6, p. 1467-1478 12 p., ddt534.

Research output: Contribution to journalArticle

Haploinsufficiency
Frontotemporal Dementia
Endocytosis
Frontotemporal Lobar Degeneration
Neurons
2013
236 Citations (Scopus)

Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS

Gendron, T. D., Bieniek, K. F., Zhang, Y., Jansen-West, K., Ash, P. E. A., Caulfield, T., Daughrity, L., Dunmore, J. H., Castanedes-Casey, M., Chew, J., Cosio, D. M., Van Blitterswijk, M., Lee, W. C., Rademakers, R. V., Boylan, K. B., Dickson, D. W. & Petrucelli, L., 2013, In : Acta Neuropathologica. 126, 6, p. 829-844 16 p.

Research output: Contribution to journalArticle

Nuclear RNA
Amyotrophic Lateral Sclerosis
RNA
Neurodegenerative Diseases
Frontal Lobe
3 Citations (Scopus)

Does obesity-induced τ phosphorylation tip the scale toward dementia?

Gendron, T. D., Zhang, Y. & Petrucelli, L., May 2013, In : Diabetes. 62, 5, p. 1365-1366 2 p.

Research output: Contribution to journalArticle

Tauopathies
tau Proteins
High Fat Diet
Dementia
Insulin Resistance
22 Citations (Scopus)

Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis

Dayton, R. D., Gitcho, M. A., Orchard, E. A., Wilson, J. D., Wang, D. B., Cain, C. D., Johnson, J. A., Zhang, Y., Petrucelli, L., Mathis, J. M. & Klein, R. L., Jul 2013, In : Molecular Therapy. 21, 7, p. 1324-1334 11 p.

Research output: Contribution to journalArticle

Forelimb
Amyotrophic Lateral Sclerosis
Cytoplasm
Phenotype
Neurons
71 Citations (Scopus)

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

Zhang, Y., Caulfield, T., Xu, Y. F., Gendron, T. D., Hubbard, J., Stetler, C., Sasaguri, H., Whitelaw, E. C., Cai, S., Lee, W. C. & Petrucelli, L., Aug 2013, In : Human Molecular Genetics. 22, 15, p. 3112-3122 11 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Amyotrophic Lateral Sclerosis
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Computer Simulation
11 Citations (Scopus)

The Pathological Phenotypes of Human TDP-43 Transgenic Mouse Models Are Independent of Downregulation of Mouse Tdp-43

Xu, Y. F., Prudencio, M., Hubbard, J. M., Tong, J., Whitelaw, E. C., Jansen-West, K., Stetler, C., Cao, X., Song, J. & Zhang, Y., Jul 26 2013, In : PLoS One. 8, 7, e69864.

Research output: Contribution to journalArticle

Tars
DNA-binding proteins
DNA-Binding Proteins
Transgenic Mice
Down-Regulation
2012
39 Citations (Scopus)

Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor

Prudencio, M., Jansen-West, K. R., Lee, W. C., Gendron, T. D., Zhang, Y., Xu, Y. F., Gass, J., Stuani, C., Stetler, C., Rademakers, R. V., Dickson, D. W., Buratti, E. & Petrucelli, L., Dec 26 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 52, p. 21510-21515 6 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Messenger RNA
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Nonsense Codon
35 Citations (Scopus)

Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction

Cannon, A., Yang, B., Knight, J., Farnham, I. M., Zhang, Y., Wuertzer, C. A., D'Alton, S., Lin, W. L., Castanedes-Casey, M., Rousseau, L., Scott, B., Jurasic, M., Howard, J., Yu, X., Bailey, R., Sarkisian, M. R., Dickson, D. W., Petrucelli, L. & Lewis, J., Jun 2012, In : Acta Neuropathologica. 123, 6, p. 807-823 17 p.

Research output: Contribution to journalArticle

Frontotemporal Dementia
TDP-43 Proteinopathies
Prosencephalon
Ubiquitin
Transgenic Mice
2011
91 Citations (Scopus)

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

Xu, Y. F., Zhang, Y., Lin, W. L., Cao, X., Stetler, C., Dickson, D. W., Lewis, J. & Petrucelli, L., 2011, In : Molecular Neurodegeneration. 6, 1, 73.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Transgenic Mice
Transcriptional Activation
aspartyl-arginyl-valyl-tyrosyl-isoleucyl-histidyl-prolyl-phenylalanyl-histidyl-leucyl-valyl-isoleucyl-histidine
Mutation
2010
130 Citations (Scopus)

Neurotoxic effects of TDP-43 overexpression in C. elegans

Ash, P. E. A., Zhang, Y., Roberts, C. M., Saldi, T., Hutter, H., Buratti, E., Petrucelli, L. & Link, C. D., Jun 8 2010, In : Human Molecular Genetics. 19, 16, p. 3206-3218 13 p., ddq230.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Phenotype
Synapses
RNA-Binding Proteins
Alternative Splicing
324 Citations (Scopus)

Tar DNA binding protein-43 (TDP-43) associates with stress granules: Analysis of cultured cells and pathological brain tissue

Liu-Yesucevitz, L., Bilgutay, A., Zhang, Y., Vanderwyde, T., Citro, A., Mehta, T., Zaarur, N., McKee, A., Bowser, R., Sherman, M., Petrucelli, L. & Wolozin, B., 2010, In : PLoS One. 5, 10, e13250.

Research output: Contribution to journalArticle

Tars
DNA-binding proteins
DNA-Binding Proteins
cultured cells
granules
291 Citations (Scopus)

Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice

Xu, Y. F., Gendron, T. D., Zhang, Y., Lin, W. L., D'Alton, S., Sheng, H., Casey, M. C., Tong, J., Knight, J., Yu, X., Rademakers, R. V., Boylan, K., Hutton, M., McGowan, E., Dickson, D. W., Lewis, J. & Petrucelli, L., Aug 11 2010, In : Journal of Neuroscience. 30, 32, p. 10851-10859 9 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Transgenic Mice
Transcriptional Activation
Phosphorylation
Mortality
2009
339 Citations (Scopus)

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

Zhang, Y., Xu, Y. F., Cook, C., Gendron, T. D., Roettges, P., Link, C. D., Lin, W. L., Tong, J., Castanedes-Casey, M., Ash, P., Gass, J., Rangachari, V., Buratti, E., Baralle, F., Golde, T. E., Dickson, D. W. & Petrucelli, L., May 5 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 18, p. 7607-7612 6 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Poisons
Inclusion Bodies
Phosphorylation
Frontotemporal Lobar Degeneration
127 Citations (Scopus)

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

Ko, H. S., Bailey, R., Smith, W. W., Liu, Z., Shin, J. H., Lee, Y. I., Zhang, Y., Jiang, H., Ross, C. A., Moore, D. J., Patterson, C., Petrucelli, L., Dawson, T. M. & Dawson, V. L., Feb 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 8, p. 2897-2902 6 p.

Research output: Contribution to journalArticle

Ubiquitination
Leucine
Phosphotransferases
Parkinson Disease
tanespimycin
2008
141 Citations (Scopus)

Akt and CHIP coregulate tau degradation through coordinated interactions

Dickey, C. A., Koren, J., Zhang, Y., Xu, Y. F., Jinwal, U. K., Birnbaum, M. J., Monks, B., Sun, M., Cheng, J. Q., Patterson, C., Bailey, R. M., Dunmore, J., Soresh, S., Leon, C., Morgan, D. & Petrucelli, L., Mar 4 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 9, p. 3622-3627 6 p.

Research output: Contribution to journalArticle

Phosphotransferases
Ligases
Alzheimer Disease
tau Proteins
Microtubule-Associated Proteins
293 Citations (Scopus)

Novel mutations in TARDBP(TDP-43) in patients with familial amyotrophic lateral sclerosis

Rutherford, N. J., Zhang, Y., Baker, M., Gass, J. M., Finch, N. A., Xu, Y. F., Stewart, H., Kelley, B. J., Kuntz, K., Crook, R. J. P., Sreedharan, J., Vance, C., Sorenson, E. J., Lippa, C., Bigio, E. H., Geschwind, D. H., Knopman, D. S., Mitsumoto, H., Petersen, R. C., Cashman, N. R. & 11 others, Hutton, M., Shaw, C. E., Boylan, K. B., Boeve, B. F., Graff Radford, N. R., Wszolek, Z. K., Caselli, R. J., Dickson, D. W., Mackenzie, I. R., Petrucelli, L. & Rademakers, R. V., Sep 2008, In : PLoS Genetics. 4, 9, e1000193.

Research output: Contribution to journalArticle

DNA-binding proteins
DNA-Binding Proteins
mutation
DNA
Mutation
18 Citations (Scopus)

TDP-43 in neurodegenerative disorders

Cook, C., Zhang, Y., Xu, Y. F., Dickson, D. W. & Petrucelli, L., Jul 2008, In : Expert Opinion on Biological Therapy. 8, 7, p. 969-978 10 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Neurodegenerative Diseases
Pathology
Mutation
Neurodegenerative diseases
2007
268 Citations (Scopus)

Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43

Zhang, Y., Xu, Y. F., Dickey, C. A., Buratti, E., Baralle, F., Bailey, R., Pickering-Brown, S., Dickson, D. W. & Petrucelli, L., Sep 26 2007, In : Journal of Neuroscience. 27, 39, p. 10530-10534 5 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Caspases
Frontotemporal Lobar Degeneration
Amyotrophic Lateral Sclerosis
Frontotemporal Dementia
2003
102 Citations (Scopus)

SEPT5_v2 is a parkin-binding protein

Choi, P., Snyder, H., Petrucelli, L., Theisler, C., Chong, M., Zhang, Y., Lim, K., Chung, K. K. K., Kehoe, K., D'Adamio, L., Lee, J. M., Cochran, E., Bowser, R., Dawson, T. M. & Wolozin, B., Oct 7 2003, In : Molecular Brain Research. 117, 2, p. 179-189 11 p.

Research output: Contribution to journalArticle

Septins
Carrier Proteins
Ubiquitination
Ubiquitin
Proteins