Wolfdieter Springer, PhD

Associate Professor

Accepting PhD Students

  • 6546 Citations
  • 20 h-Index
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  • 8 Similar Profiles
Parkinson Disease Medicine & Life Sciences
Mitochondrial Degradation Medicine & Life Sciences
Mutation Medicine & Life Sciences
Ubiquitin Medicine & Life Sciences
Mitochondria Medicine & Life Sciences
Ubiquitin-Protein Ligases Medicine & Life Sciences
Autophagy Medicine & Life Sciences
Lewy Body Disease Medicine & Life Sciences

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Projects 2014 2019

Quality Control
Unfolded Protein Response
Energy Metabolism
Parkinson Disease

Research Output 2004 2018

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

Hou, X., Fiesel, F. C., Truban, D., Castanedes Casey, M., Lin, W. L., Soto, A. I., Tacik, P., Rousseau, L. G., Diehl, N. N., Heckman, M. G., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Steele, J. C., Farrer, M. J., Cornejo-Olivas, M., Torres, L., Mata, I. F., Graff Radford, N. R., Wszolek, Z. K. & 4 othersRoss, O. A., Murray, M. E., Dickson, D. W. & Springer, W., Jan 1 2018, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Lewy Body Disease
Parkinson Disease
Carbonyl Cyanide m-Chlorophenyl Hydrazone
7 Citations (Scopus)

Hexokinases link DJ-1 to the PINK1/parkin pathway

Hauser, D. N., Mamais, A., Conti, M. M., Primiani, C. T., Kumaran, R., Dillman, A. A., Langston, R. G., Beilina, A., Garcia, J. H., Diaz-Ruiz, A., Bernier, M., Fiesel, F. C., Hou, X., Springer, W., Li, Y., De Cabo, R. & Cookson, M. R., Sep 29 2017, In : Molecular Neurodegeneration. 12, 1, 212.

Research output: Contribution to journalArticle

Parkinson Disease
PTEN Phosphohydrolase
5 Citations (Scopus)

Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy

Fiesel, F. C., James, E. D., Hudec, R. & Springer, W., Jan 1 2017, In : Oncotarget. 8, 63, p. 106233-106248 16 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Mitochondrial Proteins
34 Citations (Scopus)

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?

Truban, D., Hou, X., Caulfield, T., Fiesel, F. C. & Springer, W., 2017, In : Journal of Parkinson's Disease. 7, 1, p. 13-29 17 p.

Research output: Contribution to journalReview article

Quality Control
Parkinson Disease
Mitochondrial Degradation
Ubiquitin-Protein Ligases
30 Citations (Scopus)

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S. U., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G. E., Kang, H., Ham, S., Kam, T. I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F. C., Springer, W., Dawson, V. L., Shin, J. H. & 1 othersDawson, T. M., Jan 24 2017, In : Cell Reports. 18, 4, p. 918-932 15 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Substantia Nigra