Wolfdieter Springer, PhD

Accepting PhD Students

  • 7205 Citations
  • 21 Scopus h-Index
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  • 8 Similar Profiles
Parkinson Disease Medicine & Life Sciences
Mitochondrial Degradation Medicine & Life Sciences
Mutation Medicine & Life Sciences
Ubiquitin Medicine & Life Sciences
Mitochondria Medicine & Life Sciences
Ubiquitin-Protein Ligases Medicine & Life Sciences
Autophagy Medicine & Life Sciences
Lewy Body Disease Medicine & Life Sciences

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Projects 2014 2019

Quality Control
Unfolded Protein Response
Energy Metabolism
Parkinson Disease

Research Output 2004 2019

Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease

Luo, S., Kang, S. S., Wang, Z. H., Liu, X., Day, J. X., Wu, Z., Peng, J., Xiang, D., Springer, W. & Ye, K., Sep 11 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 37, p. 7291-7305 15 p.

Research output: Contribution to journalArticle

Parkinson Disease
Ubiquitin-Protein Ligases
Oxidative Stress
2 Citations (Scopus)

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

Lee, S. B., Kim, J. J., Han, S. A., Fan, Y., Guo, L. S., Aziz, K., Nowsheen, S., Kim, S. S., Park, S. Y., Luo, Q., Chung, J. O., Choi, S. I., Aziz, A., Yin, P., Tong, S. Y., Fiesel, F., Springer, W., Zhang, J. S. & Lou, Z., Aug 1 2019, In : Nature Cell Biology. 21, 8, p. 940-951 12 p.

Research output: Contribution to journalArticle

Receptor-Interacting Protein Serine-Threonine Kinases
AMP-Activated Protein Kinases
Ubiquitin-Protein Ligases
5 Citations (Scopus)

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

Hou, X., Fiesel, F., Truban, D., Castanedes Casey, M., Lin, W. L., Soto, A. I., Tacik, P., Rousseau, L. G., Diehl, N. N., Heckman, M. G., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Steele, J. C., Farrer, M. J., Cornejo-Olivas, M., Torres, L., Mata, I. F., Graff Radford, N. R., Wszolek, Z. K. & 4 others, Ross, O. A., Murray, M. E., Dickson, D. W. & Springer, W., Jan 1 2018, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Lewy Body Disease
Parkinson Disease
Carbonyl Cyanide m-Chlorophenyl Hydrazone
9 Citations (Scopus)

Hexokinases link DJ-1 to the PINK1/parkin pathway

Hauser, D. N., Mamais, A., Conti, M. M., Primiani, C. T., Kumaran, R., Dillman, A. A., Langston, R. G., Beilina, A., Garcia, J. H., Diaz-Ruiz, A., Bernier, M., Fiesel, F., Hou, X., Springer, W., Li, Y., De Cabo, R. & Cookson, M. R., Sep 29 2017, In : Molecular Neurodegeneration. 12, 1, 212.

Research output: Contribution to journalArticle

Parkinson Disease
PTEN Phosphohydrolase
8 Citations (Scopus)

Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy

Fiesel, F., James, E. D., Hudec, R. & Springer, W., Jan 1 2017, In : Oncotarget. 8, 63, p. 106233-106248 16 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Mitochondrial Proteins