Wolfdieter Springer, PhD

Research output

Research output per year 2004 2021

• 9246 Citations
• 25 Scopus h-Index
• 38 Article
• 6 Review article
• 1 Comment/debate
• 1 Letter

Research output per year

Research output per year

Search results

• 2021

  Early-Onset Parkinson Disease Screening in Patients From Nigeria

  Milanowski, L. M., Oshinaike, O., Broadway, B. J., Lindemann, J. A., Soto-Beasley, A. I., Walton, R. L., Hanna Al-Shaikh, R., Strongosky, A. J., Fiesel, F., Ross, O. A., Springer, W., Ogun, S. A. & Wszolek, Z. K., Jan 14 2021, In: Frontiers in Neurology. 11, 594927.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nigeria
  • Parkinson Disease
  • Population Groups
  • Neurodegenerative Diseases
  • Population
• 2020

  Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

  Park, J. H., Burgess, J. D., Faroqi, A. H., Demeo, N. N., Fiesel, F. C., Springer, W., Delenclos, M. & McLean, P. J., Jan 13 2020, In: Molecular neurodegeneration. 15, 1, 5.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sirtuin 3
  • Synucleins
  • alpha-Synuclein
  • Parkinson Disease
  • Mitochondrial Dynamics
  11 Scopus citations

• Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

  Hou, X., Watzlawik, J. O., Cook, C., Liu, C. C., Kang, S. S., Lin, W. L., DeTure, M., Heckman, M. G., Diehl, N. N., Al-Shaikh, F. S. H., Walton, R. L., Ross, O. A., Melrose, H. L., Ertekin-Taner, N., Bu, G., Petrucelli, L., Fryer, J. D., Murray, M. E., Dickson, D. W., Fiesel, F. C. & 1 others, Springer, W., 2020, (Accepted/In press) In: Alzheimer's and Dementia.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitochondrial Degradation
  • Alzheimer Disease
  • Pathology
  • Mitochondria
  • Brain
  4 Scopus citations

• Screening non-MAPT genes of the Chr17q21 H1 haplotype in Parkinson's disease

  Soto-Beasley, A. I., Walton, R. L., Valentino, R. R., Hook, P. W., Labbé, C., Heckman, M. G., Johnson, P. W., Goff, L. A., Uitti, R. J., McLean, P. J., Springer, W., McCallion, A. S., Wszolek, Z. K. & Ross, O. A., Sep 2020, In: Parkinsonism and Related Disorders. 78, p. 138-144 7 p.

  Research output: Contribution to journal › Article › peer-review

  • tau Proteins
  • Microtubule-Associated Proteins
  • Haplotypes
  • Parkinson Disease
  • Linkage Disequilibrium
  1 Scopus citations

• Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples

  Watzlawik, J. O., Hou, X., Truban, D., Ramnarine, C., Barodia, S. K., Gendron, T. F., Heckman, M. G., DeTure, M., Siuda, J., Wszolek, Z. K., Scherzer, C. R., Ross, O. A., Bu, G., Dickson, D. W., Goldberg, M. S., Fiesel, F. C. & Springer, W., 2020, (Accepted/In press) In: Autophagy.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitochondrial Degradation
  • Ubiquitin
  • Autopsy
  • Enzyme-Linked Immunosorbent Assay
  • Brain
  3 Scopus citations
• 2019

  Akt phosphorylates NQO1 and triggers its degradation, abolishing its antioxidative activities in Parkinson’s disease

  Luo, S., Kang, S. S., Wang, Z. H., Liu, X., Day, J. X., Wu, Z., Peng, J., Xiang, D., Springer, W. & Ye, K., 2019, In: Journal of Neuroscience. 39, 37, p. 7291-7305 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Parkinson Disease
  • quinone
  • Oxidoreductases
  • Synucleins
  • Phosphorylation
  11 Scopus citations

• The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

  Lee, S. B., Kim, J. J., Han, S. A., Fan, Y., Guo, L. S., Aziz, K., Nowsheen, S., Kim, S. S., Park, S. Y., Luo, Q., Chung, J. O., Choi, S. I., Aziz, A., Yin, P., Tong, S. Y., Fiesel, F. C., Springer, W., Zhang, J. S. & Lou, Z., Aug 1 2019, In: Nature Cell Biology. 21, 8, p. 940-951 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Carcinogenesis
  • Inflammation
  • Receptor-Interacting Protein Serine-Threonine Kinases
  • AMP-Activated Protein Kinases
  • Ubiquitin-Protein Ligases
  27 Scopus citations
• 2018

  Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

  Hou, X., Fiesel, F. C., Truban, D., Castanedes Casey, M., Lin, W. L., Soto, A. I., Tacik, P., Rousseau, L. G., Diehl, N. N., Heckman, M. G., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Steele, J. C., Farrer, M. J., Cornejo-Olivas, M., Torres, L., Mata, I. F., Graff-Radford, N. R., Wszolek, Z. K. & 4 others, Ross, O. A., Murray, M. E., Dickson, D. W. & Springer, W., Aug 3 2018, In: Autophagy. 14, 8, p. 1404-1418 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial Degradation
  • Lewy Body Disease
  • Ubiquitin
  • Parkinson Disease
  • Carbonyl Cyanide m-Chlorophenyl Hydrazone
  23 Scopus citations
• 2017

  Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism

  Puschmann, A., Fiesel, F. C., Caulfield, T. R., Hudec, R., Ando, M., Truban, D., Hou, X., Ogaki, K., Heckman, M. G., James, E. D., Swanberg, M., Jimenez-Ferrer, I., Hansson, O., Opala, G., Siuda, J., Boczarska-Jedynak, M., Friedman, A., Koziorowski, D., Rudzińska-Bar, M., Aasly, J. O. & 13 others, Lynch, T., Mellick, G. D., Mohan, M., Silburn, P. A., Sanotsky, Y., Vilariño-Güell, C., Farrer, M. J., Chen, L., Dawson, V. L., Dawson, T. M., Wszolek, Z. K., Ross, O. A. & Springer, W., Jan 2017, In: Brain. 140, 1, p. 98-117 20 p.

  Research output: Contribution to journal › Article › peer-review

  • PTEN-induced putative kinase
  • Parkinson Disease
  • Heterozygote
  • Mutation
  • Odds Ratio
  68 Scopus citations

• Hexokinases link DJ-1 to the PINK1/parkin pathway

  Hauser, D. N., Mamais, A., Conti, M. M., Primiani, C. T., Kumaran, R., Dillman, A. A., Langston, R. G., Beilina, A., Garcia, J. H., Diaz-Ruiz, A., Bernier, M., Fiesel, F. C., Hou, X., Springer, W., Li, Y., De Cabo, R. & Cookson, M. R., Sep 29 2017, In: Molecular neurodegeneration. 12, 1, 212.

  Research output: Contribution to journal › Article › peer-review

  • Hexokinase
  • Parkinson Disease
  • MK 2206
  • Mitochondria
  • Brain
  20 Scopus citations

• Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy

  Fiesel, F. C., James, E. D., Hudec, R. & Springer, W., 2017, In: Oncotarget. 8, 63, p. 106233-106248 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial Degradation
  • Autophagy
  • Mitochondria
  • gamitrinib-triphenylphosphonium
  • Mitochondrial Proteins
  15 Scopus citations

• PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

  Lee, Y., Stevens, D. A., Kang, S. U., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G. E., Kang, H., Ham, S., Kam, T. I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F. C., Springer, W., Dawson, V. L., Shin, J. H. & 1 others, Dawson, T. M., Jan 24 2017, In: Cell reports. 18, 4, p. 918-932 15 p.

  Research output: Contribution to journal › Article › peer-review

  • PTEN-induced putative kinase
  • Ubiquitination
  • Dopaminergic Neurons
  • Neurons
  • Phosphorylation
  69 Scopus citations

• The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

  Ando, M., Fiesel, F. C., Hudec, R., Caulfield, T. R., Ogaki, K., Górka-Skoczylas, P., Koziorowski, D., Friedman, A., Chen, L., Dawson, V. L., Dawson, T. M., Bu, G., Ross, O. A., Wszolek, Z. K. & Springer, W., Apr 24 2017, In: Molecular neurodegeneration. 12, 1, 32.

  Research output: Contribution to journal › Article › peer-review

  • Protein Stability
  • Ubiquitin
  • Phosphotransferases
  • Mutation
  • Mitochondrial Membranes
  25 Scopus citations

• Waldenstrom macroglobulinemia cells devoid of BTK C481S or CXCR4 WHIM-like mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment

  Paulus, A., Akhtar, S., Yousaf, H., Manna, A., Paulus, S. M., Bashir, Y., Caulfield, T. R., Kuranz-Blake, M., Chitta, K., Wang, X., Asmann, Y., Hudec, R., Springer, W., Ailawadhi, S. & Chanan-Khan, A., May 26 2017, In: Blood cancer journal. 7, 5, 201740.

  Research output: Contribution to journal › Article › peer-review

  • MK 2206
  • venetoclax
  • PCI 32765
  • Waldenstrom Macroglobulinemia
  • Up-Regulation
  26 Scopus citations
• 2016

  MiR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

  Kim, J., Fiesel, F. C., Belmonte, K. C., Hudec, R., Wang, W. X., Kim, C., Nelson, P. T., Springer, W. & Kim, J., Jul 26 2016, In: Molecular neurodegeneration. 11, 1, 55.

  Research output: Contribution to journal › Article › peer-review

  • PTEN-induced putative kinase
  • Mitochondria
  • MicroRNAs
  • Mitochondrial Degradation
  • Parkinson Disease
  45 Scopus citations
• 2015

  (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

  Fiesel, F. C., Ando, M., Hudec, R., Hill, A. R., Castanedes-Casey, M., Caulfield, T. R., Moussaud-Lamodière, E. L., Stankowski, J. N., Bauer, P. O., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Siuda, J., Chen, L., Dawson, V. L., Dawson, T. M., Wszolek, Z. K., Ross, O. A., Dickson, D. W. & Springer, W., Sep 1 2015, In: EMBO Reports. 16, 9, p. 1114-1130 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphorylation
  • Ubiquitin
  • Parkinson Disease
  • Brain
  • Mitochondria
  76 Scopus citations

• Activation of the E3 ubiquitin ligase Parkin

  Caulfield, T. R., Fiesel, F. C. & Springer, W., Apr 1 2015, In: Biochemical Society Transactions. 43, p. 269-274 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Ubiquitin-Protein Ligases
  • Phosphorylation
  • Ubiquitin
  • Chemical activation
  • Conformations
  32 Scopus citations

• Disease relevance of phosphorylated ubiquitin (p-S65-Ub)

  Fiesel, F. C. & Springer, W., Jan 1 2015, In: Autophagy. 11, 11, p. 2125-2126 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Ubiquitin
  • Mitochondria
  • Mitochondrial Degradation
  • Ubiquitin-Protein Ligases
  • Lysosomes
  11 Scopus citations

• DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients

  Lorenzo-Betancor, O., Ogaki, K., Soto-Ortolaza, A. I., Labbe, C., Walton, R. L., Strongosky, A. J., van Gerpen, J. A., Uitti, R. J., Mclean, P. J., Springer, W., Siuda, J., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K., Mccarthy, A., Lynch, T., Puschmann, A., Rektorova, I., Sanotsky, Y. & 10 others, Vilariño-Güell, C., Farrer, M. J., Ferman, T. J., Boeve, B. F., Petersen, R. C., Parisi, J. E., Graff-Radford, N. R., Dickson, D. W., Wszolek, Z. K. & Ross, O. A., Sep 1 2015, In: European Journal of Neurology. 22, 9, p. 1323-1325 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Lewy Body Disease
  • Parkinson Disease
  • Exons
  • Mutation
  • Parkinson Disease, Familial, Type 1
  15 Scopus citations

• Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders

  Ogaki, K., Koga, S., Heckman, M. G., Fiesel, F. C., Ando, M., Labbé, C., Lorenzo-Betancor, O., Moussaud-Lamodière, E. L., Soto-Ortolaza, A. I., Walton, R. L., Strongosky, A. J., Uitti, R. J., McCarthy, A., Lynch, T., Siuda, J., Opala, G., Rudzinska, M., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K. & 12 others, Puschmann, A., Nishioka, K., Funayama, M., Hattori, N., Parisi, J. E., Petersen, R. C., Graff-Radford, N. R., Boeve, B. F., Springer, W., Wszolek, Z. K., Dickson, D. W. & Ross, O. A., Dec 8 2015, In: Neurology. 85, 23, p. 2016-2025 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Lewy Bodies
  • Lewy Body Disease
  • Parkinson Disease
  • Genes
  • Exons
  33 Scopus citations

• NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1

  Shi, J., Fung, G., Deng, H., Zhang, J., Fiesel, FC., Springer, W., Li, X. & Luo, H., Oct 1 2015, In: Cell Death and Disease. 6, 10, e1943.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial Degradation
  • Mitochondria
  • Proteins
  • Quality Control
  • Cluster Analysis
  21 Scopus citations

• Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

  Yue, M., Hinkle, K. M., Davies, P., Trushina, E., Fiesel, F. C., Christenson, T. A., Schroeder, A. S., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S. J., Beevers, J. E., Milnerwood, A. J., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D. W., Farrer, M. J. & Melrose, H. L., Jun 1 2015, In: Neurobiology of Disease. 78, p. 172-195 24 p.

  Research output: Contribution to journal › Article › peer-review

  • Mutation
  • Dopamine
  • Phosphotransferases
  • Late Onset Disorders
  • Mitochondrial Dynamics
  105 Scopus citations

• Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

  Fiesel, F. C., Caulfield, T. R., Moussaud-Lamodière, E. L., Ogaki, K., Dourado, D. F. A. R., Flores, S. C., Ross, O. A. & Springer, W., Aug 1 2015, In: Human mutation. 36, 8, p. 774-786 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Ubiquitin-Protein Ligases
  • Parkinson Disease
  • Coenzymes
  • Mutation
  • Missense Mutation
  40 Scopus citations
• 2014

  A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently

  Fiesel, F. C., Moussaud-Lamodière, E. L., Ando, M. & Springer, W., 2014, In: Journal of cell science. 127, 16, p. 3488-3504 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Ubiquitin-Conjugating Enzymes
  • Mitochondrial Degradation
  • Mitochondria
  • Ubiquitin
  • Cluster Analysis
  43 Scopus citations

• Early-onset Parkinson's disease due to PINK1 p.Q456X mutation - Clinical and functional study

  Siuda, J., Jasinska-Myga, B., Boczarska-Jedynak, M., Opala, G., Fiesel, F. C., Moussaud-Lamodière, E. L., Scarffe, L. A., Dawson, V. L., Ross, O. A., Springer, W., Dawson, T. M. & Wszolek, Z. K., Nov 1 2014, In: Parkinsonism and Related Disorders. 20, 11, p. 1274-1278 5 p.

  Research output: Contribution to journal › Article › peer-review

  • PTEN-induced putative kinase
  • Parkinson Disease
  • Clinical Studies
  • Mutation
  • Dystonic Disorders
  21 Scopus citations

• Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease

  Shannon, B., Soto-Ortolaza, A., Rayaprolu, S., Cannon, H. D., Labbé, C., Benitez, B. A., Choi, J., Lynch, T., Boczarska-Jedynak, M., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Van Gerpen, J. A., Uitti, R. J., Springer, W., Cruchaga, C., Wszolek, Z. K. & Ross, O. A., Aug 2014, In: Neurobiology of aging. 35, 8, p. 1958.e1-1958.e2

  Research output: Contribution to journal › Article › peer-review

  • Genetic Variation
  • Parkinson Disease
  • Late Onset Disorders
  • Genes
  • Mutation
  17 Scopus citations

• Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin

  Caulfield, T. R., Fiesel, F. C., Moussaud-Lamodière, E. L., Dourado, D. F. A. R., Flores, S. C. & Springer, W., Nov 1 2014, In: PLoS computational biology. 10, 11

  Research output: Contribution to journal › Article › peer-review

  • Phosphorylation
  • ubiquitin-protein ligase
  • Conformation
  • Conformations
  • Ubiquitin-Protein Ligases
  68 Scopus citations

• Three families with Perry syndrome from distinct parts of the world

  Tacik, P., Fiesel, F. C., Fujioka, S., Ross, O. A., Pretelt, F., Castañeda Cardona, C., Kidd, A., Hlavac, M., Raizis, A., Okun, M. S., Traynor, S., Strongosky, A. J., Springer, W. & Wszolek, Z. K., Aug 2014, In: Parkinsonism and Related Disorders. 20, 8, p. 884-888 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Perry Syndrome
  • Dynactin Complex
  • Respiratory Insufficiency
  • Parkinsonian Disorders
  • New Zealand
  18 Scopus citations

• UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase y regulate TDP-43 protein ubiquitination

  Hans, F., Fiesel, F. C., Strong, J. C., Jackel, S., Rasse, T. M., Geisler, S., Springer, W., Schulz, J. B., Voigt, A. & Kahle, P. J., Jul 4 2014, In: Journal of Biological Chemistry. 289, 27, p. 19164-19179 16 p.

  Research output: Contribution to journal › Article › peer-review

  • ubiquitin isopeptidase
  • Ubiquitin-Conjugating Enzymes
  • Ubiquitination
  • Neurodegenerative diseases
  • Cell culture
  38 Scopus citations
• 2013

  LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer's Disease (LOAD)

  Lincoln, S., Allen, M., Cox, C. L., Walker, L. P., Malphrus, K., Qiu, Y., Nguyen, T., Rowley, C., Kouri, N., Crook, J., Pankratz, V. S., Younkin, S., Younkin, L., Carrasquillo, M., Zou, F., Abdul-Hay, S. O., Springer, W., Sando, S. B., Aasly, J. O., Barcikowska, M. & 8 others, Wszolek, Z. K., Lewis, J. M., Dickson, D., Graff-Radford, N. R., Petersen, R. C., Eckman, E., Younkin, S. G. & Ertekin-Taner, N., Jun 4 2013, In: PloS one. 8, 6, e64164.

  Research output: Contribution to journal › Article › peer-review

  • leucine-rich repeat proteins
  • Alzheimer disease
  • transmembrane proteins
  • Leucine
  • leucine
  8 Scopus citations
• 2010

  Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

  Fiesel, F. C., Voigt, A., Weber, S. S., Van Den Haute, C., Waldenmaier, A., Görner, K., Walter, M., Marlene, A. L., Kern, J. V., Rasse, T. M., Schmidt, T., Springer, W., Kirchner, R., Bonin, M., Neumann, M., Baekelandt, V., Alunni-Fabbroni, M., Schulz, J. B. & Kahle, P. J., Jan 6 2010, In: EMBO Journal. 29, 1, p. 209-221 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Histone Deacetylase 6
  • DNA-Binding Proteins
  • Down-Regulation
  • Messenger RNA
  • Ataxin-3
  170 Scopus citations

• Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans

  Cornejo Castro, E. M., Waak, J., Weber, S. S., Fiesel, F. C., Oberhettinger, P., Schütz, M., Autenrieth, I. B., Springer, W. & Kahle, P. J., May 2010, In: Journal of Neural Transmission. 117, 5, p. 599-604 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Caenorhabditis elegans
  • Innate Immunity
  • Parkinson Disease
  • p38 Mitogen-Activated Protein Kinases
  • Gram-Negative Bacteria
  21 Scopus citations

• PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

  Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J. & Springer, W., Feb 2010, In: Nature Cell Biology. 12, 2, p. 119-131 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Voltage-Dependent Anion Channel 1
  • Mitochondrial Degradation
  • Ubiquitination
  • Parkinson Disease
  • Mitochondria
  1667 Scopus citations

• The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

  Geisler, S., Holmström, K. M., Treis, A., Skujat, D., Weber, S. S., Fiesel, F. C., Kahle, P. J. & Springer, W., Oct 1 2010, In: Autophagy. 6, 7, p. 871-878 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial Degradation
  • Parkinson Disease
  • Mitochondria
  • Mutation
  • Autophagy
  190 Scopus citations
• 2009

  Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

  Klein, C. L., Rovelli, G., Springer, W., Schall, C., Gasser, T. & Kahle, P. J., Nov 2009, In: Journal of neurochemistry. 111, 3, p. 703-715 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Hominidae
  • Leucine
  • Phosphotransferases
  • Parkinson Disease
  • Dimerization
  65 Scopus citations
• 2008

  Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways

  Hasegawa, T., Treis, A., Patenge, N., Fiesel, F. C., Springer, W. & Kahle, P. J., Jun 2008, In: Journal of neurochemistry. 105, 5, p. 1700-1715 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Monophenol Monooxygenase
  • Heat-Shock Proteins
  • Protein Kinases
  • Parkinson Disease
  • Dopamine
  65 Scopus citations
• 2005

  A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress

  Springer, W., Hoppe, T., Schmidt, E. & Baumeister, R., Nov 15 2005, In: Human molecular genetics. 14, 22, p. 3407-3423 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Caenorhabditis elegans
  • Solubility
  • Parkinsonian Disorders
  • Mutation
  88 Scopus citations
• 2004

  Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans

  Hoppe, T., Cassata, G., Barral, J. M., Springer, W., Hutagalung, A. H., Epstein, H. F. & Baumeister, R., Aug 6 2004, In: Cell. 118, 3, p. 337-349 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Caenorhabditis elegans
  • Myosins
  • Animals
  • Muscle
  • Yeast
  106 Scopus citations