Wolfdieter Springer, PhD

  • 7311 Citations
  • 21 Scopus h-Index
20042019
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Research Output 2004 2019

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Article
2019
2 Citations (Scopus)

Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease

Luo, S., Kang, S. S., Wang, Z. H., Liu, X., Day, J. X., Wu, Z., Peng, J., Xiang, D., Springer, W. & Ye, K., Sep 11 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 37, p. 7291-7305 15 p.

Research output: Contribution to journalArticle

Parkinson Disease
Oxidoreductases
Ubiquitin-Protein Ligases
Dopamine
Oxidative Stress
2 Citations (Scopus)

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

Lee, S. B., Kim, J. J., Han, S. A., Fan, Y., Guo, L. S., Aziz, K., Nowsheen, S., Kim, S. S., Park, S. Y., Luo, Q., Chung, J. O., Choi, S. I., Aziz, A., Yin, P., Tong, S. Y., Fiesel, F., Springer, W., Zhang, J. S. & Lou, Z., Aug 1 2019, In : Nature Cell Biology. 21, 8, p. 940-951 12 p.

Research output: Contribution to journalArticle

Carcinogenesis
Inflammation
Receptor-Interacting Protein Serine-Threonine Kinases
AMP-Activated Protein Kinases
Ubiquitin-Protein Ligases
2018
5 Citations (Scopus)

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

Hou, X., Fiesel, F., Truban, D., Castanedes Casey, M., Lin, W. L., Soto, A. I., Tacik, P., Rousseau, L. G., Diehl, N. N., Heckman, M. G., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Steele, J. C., Farrer, M. J., Cornejo-Olivas, M., Torres, L., Mata, I. F., Graff Radford, N. R., Wszolek, Z. K. & 4 others, Ross, O. A., Murray, M. E., Dickson, D. W. & Springer, W., Jan 1 2018, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Lewy Body Disease
Ubiquitin
Parkinson Disease
Carbonyl Cyanide m-Chlorophenyl Hydrazone
2017
9 Citations (Scopus)

Hexokinases link DJ-1 to the PINK1/parkin pathway

Hauser, D. N., Mamais, A., Conti, M. M., Primiani, C. T., Kumaran, R., Dillman, A. A., Langston, R. G., Beilina, A., Garcia, J. H., Diaz-Ruiz, A., Bernier, M., Fiesel, F., Hou, X., Springer, W., Li, Y., De Cabo, R. & Cookson, M. R., Sep 29 2017, In : Molecular Neurodegeneration. 12, 1, 212.

Research output: Contribution to journalArticle

Hexokinase
Parkinson Disease
Mitochondria
Brain
PTEN Phosphohydrolase
8 Citations (Scopus)

Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy

Fiesel, F., James, E. D., Hudec, R. & Springer, W., Jan 1 2017, In : Oncotarget. 8, 63, p. 106233-106248 16 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Autophagy
Mitochondria
Mitochondrial Proteins
Polyubiquitin
38 Citations (Scopus)

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S. U., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G. E., Kang, H., Ham, S., Kam, T. I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F., Springer, W., Dawson, V. L., Shin, J. H. & 1 others, Dawson, T. M., Jan 24 2017, In : Cell Reports. 18, 4, p. 918-932 15 p.

Research output: Contribution to journalArticle

Ubiquitination
Dopaminergic Neurons
Neurons
Phosphorylation
Substantia Nigra
12 Citations (Scopus)

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Ando, M., Fiesel, F., Hudec, R., Caulfield, T., Ogaki, K., Górka-Skoczylas, P., Koziorowski, D., Friedman, A., Chen, L., Dawson, V. L., Dawson, T. M., Bu, G. D., Ross, O. A., Wszolek, Z. K. & Springer, W., Apr 24 2017, In : Molecular Neurodegeneration. 12, 1, 32.

Research output: Contribution to journalArticle

Protein Stability
Ubiquitin
Phosphotransferases
Mutation
Mitochondrial Membranes
11 Citations (Scopus)
Waldenstrom Macroglobulinemia
Up-Regulation
Mutation
Therapeutics
Phosphatidylinositol 3-Kinases
2016
26 Citations (Scopus)

MiR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

Kim, J., Fiesel, F., Belmonte, K. C., Hudec, R., Wang, W. X., Kim, C., Nelson, P. T., Springer, W. & Kim, J., Jul 26 2016, In : Molecular Neurodegeneration. 11, 1, 55.

Research output: Contribution to journalArticle

Mitochondria
MicroRNAs
Mitochondrial Degradation
Parkinson Disease
PTEN-induced putative kinase
2015
52 Citations (Scopus)

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

Fiesel, F., Ando, M., Hudec, R., Hill, A. R., Castanedes-Casey, M., Caulfield, T., Moussaud-Lamodière, E. L., Stankowski, J. N., Bauer, P. O., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Siuda, J., Chen, L., Dawson, V. L., Dawson, T. M., Wszolek, Z. K., Ross, O. A., Dickson, D. W. & Springer, W., Sep 1 2015, In : EMBO Reports. 16, 9, p. 1114-1130 17 p.

Research output: Contribution to journalArticle

Phosphorylation
Ubiquitin
Parkinson Disease
Brain
Mitochondria
23 Citations (Scopus)

Activation of the E3 ubiquitin ligase Parkin

Caulfield, T., Fiesel, F. & Springer, W., Apr 1 2015, In : Biochemical Society Transactions. 43, p. 269-274 6 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitin
Phosphorylation
Chemical activation
Autophagy
8 Citations (Scopus)

Disease relevance of phosphorylated ubiquitin (p-S65-Ub)

Fiesel, F. & Springer, W., Jan 1 2015, In : Autophagy. 11, 11, p. 2125-2126 2 p.

Research output: Contribution to journalArticle

Ubiquitin
Mitochondria
Mitochondrial Degradation
Ubiquitin-Protein Ligases
Lysosomes
12 Citations (Scopus)

DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients

Lorenzo-Betancor, O., Ogaki, K., Soto-Ortolaza, A. I., Labbe, C., Walton, R. L., Strongosky, A. J., Van Gerpen, J. A., Uitti, R. J., McLean, P. J., Springer, W., Siuda, J., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K., Mccarthy, A., Lynch, T., Puschmann, A., Rektorova, I., Sanotsky, Y. & 10 others, Vilariño-Güell, C., Farrer, M. J., Ferman, T. J., Boeve, B. F., Petersen, R. C., Parisi, J. E., Graff Radford, N. R., Dickson, D. W., Wszolek, Z. K. & Ross, O. A., Sep 1 2015, In : European Journal of Neurology. 22, 9, p. 1323-1325 3 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Parkinson Disease
Exons
Mutation
Introns
27 Citations (Scopus)

Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders

Ogaki, K., Koga, S., Heckman, M. G., Fiesel, F., Ando, M., Labbé, C., Lorenzo-Betancor, O., Moussaud-Lamodière, E. L., Soto-Ortolaza, A. I., Walton, R. L., Strongosky, A. J., Uitti, R. J., McCarthy, A., Lynch, T., Siuda, J., Opala, G., Rudzinska, M., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K. & 12 others, Puschmann, A., Nishioka, K., Funayama, M., Hattori, N., Parisi, J. E., Petersen, R. C., Graff Radford, N. R., Boeve, B. F., Springer, W., Wszolek, Z. K., Dickson, D. W. & Ross, O. A., Dec 8 2015, In : Neurology. 85, 23, p. 2016-2025 10 p.

Research output: Contribution to journalArticle

Lewy Bodies
Lewy Body Disease
Parkinson Disease
Genes
Exons
13 Citations (Scopus)

NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1

Shi, J., Fung, G., Deng, H., Zhang, J., Fiesel, F., Springer, W., Li, X. & Luo, H., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1943.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Mitochondria
Proteins
Quality Control
Cluster Analysis
70 Citations (Scopus)

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Yue, M., Hinkle, K. M., Davies, P., Trushina, E. D., Fiesel, F., Christenson, T. A., Schroeder, A. S., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S. J., Beevers, J. E., Milnerwood, A. J., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D. W., Farrer, M. J. & Melrose, H. L., Jun 1 2015, In : Neurobiology of Disease. 78, p. 172-195 24 p.

Research output: Contribution to journalArticle

Mutation
Dopamine
Phosphotransferases
Mitochondrial Dynamics
Microdialysis
31 Citations (Scopus)

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

Fiesel, F., Caulfield, T., Moussaud-Lamodière, E. L., Ogaki, K., Dourado, D. F. A. R., Flores, S. C., Ross, O. A. & Springer, W., Aug 1 2015, In : Human Mutation. 36, 8, p. 774-786 13 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Parkinson Disease
Mutation
Coenzymes
Missense Mutation
2014
35 Citations (Scopus)

A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently

Fiesel, F., Moussaud-Lamodière, E. L., Ando, M. & Springer, W., 2014, In : Journal of Cell Science. 127, 16, p. 3488-3504 17 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Ubiquitin-Conjugating Enzymes
Mitochondria
Ubiquitin
Cluster Analysis
17 Citations (Scopus)

Early-onset Parkinson's disease due to PINK1 p.Q456X mutation - Clinical and functional study

Siuda, J., Jasinska-Myga, B., Boczarska-Jedynak, M., Opala, G., Fiesel, F., Moussaud-Lamodière, E. L., Scarffe, L. A., Dawson, V. L., Ross, O. A., Springer, W., Dawson, T. M. & Wszolek, Z. K., Nov 1 2014, In : Parkinsonism and Related Disorders. 20, 11, p. 1274-1278 5 p.

Research output: Contribution to journalArticle

Parkinson Disease
Mutation
Dystonic Disorders
Ubiquitination
Gait
14 Citations (Scopus)

Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease

Shannon, B., Soto-Ortolaza, A., Rayaprolu, S., Cannon, H. D., Labbé, C., Benitez, B. A., Choi, J., Lynch, T., Boczarska-Jedynak, M., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Van Gerpen, J. A., Uitti, R. J., Springer, W., Cruchaga, C., Wszolek, Z. K. & Ross, O. A., 2014, In : Neurobiology of Aging. 35, 8

Research output: Contribution to journalArticle

Parkinson Disease
Genes
Mutation
Late Onset Disorders
52 Citations (Scopus)

Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin

Caulfield, T., Fiesel, F., Moussaud-Lamodière, E. L., Dourado, D. F. A. R., Flores, S. C. & Springer, W., Nov 1 2014, In : PLoS Computational Biology. 10, 11

Research output: Contribution to journalArticle

ubiquitin-protein ligase
Phosphorylation
Ubiquitin-Protein Ligases
Conformation
Conformations
13 Citations (Scopus)

Three families with Perry syndrome from distinct parts of the world

Tacik, P., Fiesel, F., Fujioka, S., Ross, O. A., Pretelt, F., Castañeda Cardona, C., Kidd, A., Hlavac, M., Raizis, A., Okun, M. S., Traynor, S., Strongosky, A. J., Springer, W. & Wszolek, Z. K., 2014, In : Parkinsonism and Related Disorders. 20, 8, p. 884-888 5 p.

Research output: Contribution to journalArticle

Respiratory Insufficiency
Parkinsonian Disorders
New Zealand
Mutation
Early Diagnosis
27 Citations (Scopus)

UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase y regulate TDP-43 protein ubiquitination

Hans, F., Fiesel, F., Strong, J. C., Jackel, S., Rasse, T. M., Geisler, S., Springer, W., Schulz, J. B., Voigt, A. & Kahle, P. J., Jul 4 2014, In : Journal of Biological Chemistry. 289, 27, p. 19164-19179 16 p.

Research output: Contribution to journalArticle

Ubiquitin-Conjugating Enzymes
Ubiquitination
Neurodegenerative diseases
Ubiquitin
Cell culture
2013
7 Citations (Scopus)

LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer's Disease (LOAD)

Lincoln, S., Allen, M., Cox, C. L., Walker, L. P., Malphrus, K., Qiu, Y., Nguyen, T., Rowley, C., Kouri, N., Crook, J., Pankratz, V. S., Younkin, S., Younkin, L., Carrasquillo, M. M., Zou, F., Abdul-Hay, S. O., Springer, W., Sando, S. B., Aasly, J. O., Barcikowska, M. & 8 others, Wszolek, Z. K., Lewis, J. M., Dickson, D. W., Graff Radford, N. R., Petersen, R. C., Eckman, E., Younkin, S. G. & Taner, N., Jun 4 2013, In : PLoS One. 8, 6, e64164.

Research output: Contribution to journalArticle

transmembrane proteins
Alzheimer disease
Leucine
leucine
Alzheimer Disease
2012
2379 Citations (Scopus)

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Al-Younes, H. M., Al-Zeer, M. A., Albert, M. L., Albin, R. L., Alegre-Abarrategui, J. & 1,249 others, Aleo, M. F., Alirezaei, M., Almasan, A., Almonte-Becerril, M., Amano, A., Amaravadi, R., Amarnath, S., Amer, A. O., Andrieu-Abadie, N., Anantharam, V., Ann, D. K., Anoopkumar-Dukie, S., Aoki, H., Apostolova, N., Arancia, G., Aris, J. P., Asanuma, K., Asare, N. Y. O., Ashida, H., Askanas, V., Askew, D. S., Auberger, P., Baba, M., Backues, S. K., Baehrecke, E. H., Bahr, B. A., Bai, X. Y., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Bamber, B. A., Bampton, E. T. W., Bánhegyi, G., Bartholomew, C. R., Bassham, D. C., Bast, R. C., Batoko, H., Bay, B. H., Beau, I., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Bernassola, F., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Boise, L. H., Bonaldo, P., Boone, D. L., Bornhauser, B. C., Bortoluci, K. R., Bossis, I., Bost, F., Bourquin, J. P., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Brenman, J. E., Brennand, A., Bresnick, E. H., Brest, P., Bridges, D., Bristol, M. L., Brookes, P. S., Brown, E. J., Brumell, J. H., Brunetti-Pierri, N., Brunk, U. T., Bulman, D. E., Bultman, S. J., Bultynck, G., Burbulla, L. F., Bursch, W., Butchar, J. P., Buzgariu, W., Bydlowski, S. P., Cadwell, K., Cahová, M., Cai, D., Cai, J., Cai, Q., Calabretta, B., Calvo-Garrido, J., Camougrand, N., Campanella, M., Campos-Salinas, J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Carew, J. S., Carlin, C. R., Carmignac, V., Carneiro, L. A. M., Carra, S., Caruso, R. A., Casari, G., Casas, C., Castino, R., Cebollero, E., Cecconi, F., Celli, J., Chaachouay, H., Chae, H. J., Chai, C. Y., Chan, D. C., Chan, E. Y., Chang, R. C. C., Che, C. M., Chen, C. C., Chen, G. C., Chen, G. Q., Chen, M., Chen, Q., Chen, S. S. L., Chen, W., Chen, X., Chen, X., Chen, X., Chen, Y. G., Chen, Y., Chen, Y., Chen, Y. J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Cheong, H., Cheong, J. H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H. L., Chiarelli, R., Chiba, T., Chin, L. S., Chiou, S. H., Chisari, F. V., Cho, C. H., Cho, D. H., Choi, A. M. K., Choi, D., Choi, K. S., Choi, M. E., Chouaib, S., Choubey, D., Choubey, V., Chu, C. T., Chuang, T. H., Chueh, S. H., Chun, T., Chwae, Y. J., Chye, M. L., Ciarcia, R., Ciriolo, M. R., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Clarke, R., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condello, M., Condorelli, F., Cookson, M. R., Coombs, G. H., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M., Cullen, J. J., Czaja, M. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., De Groot, J. F., De Haan, C. A. M., De Martino, L., De Milito, A., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Deng, Y. Z., Dengjel, J., Dent, P., Denton, D., Deretic, V., Desai, S. D., Devenish, R. J., Di Gioacchino, M., Di Paolo, G., Di Pietro, C., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Diaz-Nido, J., Dikic, I., Dinesh-Kumar, S. P., Ding, W. X., Distelhorst, C. W., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Dorsey, F. C., Dosenko, V., Dowling, J. J., Doxsey, S., Dreux, M., Drew, M. E., Duan, Q., Duchosal, M. A., Duff, K., Dugail, I., Durbeej, M., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Eissa, N. T., Ekmekcioglu, S., El-Deiry, W. S., Elazar, Z., Elgendy, M., Ellerby, L. M., Er Eng, K., Engelbrecht, A. M., Engelender, S., Erenpreisa, J., Escalante, R., Esclatine, A., Eskelinen, E. L., Espert, L., Espina, V., Fan, H., Fan, J., Fan, Q. W., Fan, Z., Fang, S., Fang, Y., Fanto, M., Fanzani, A., Farkas, T., Farré, J. C., Faure, M., Fechheimer, M., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Fiorito, F., Fisher, E. A., Fisher, P. B., Flajolet, M., Florez-McClure, M. L., Florio, S., Fon, E. A., Fornai, F., Fortunato, F., Fotedar, R., Fowler, D. H., Fox, H. S., Franco, R., Frankel, L. B., Fransen, M., Fuentes, J. M., Fueyo, J., Fujii, J., Fujisaki, K., Fujita, E., Fukuda, M., Furukawa, R. H., Gaestel, M., Gailly, P., Gajewska, M., Galliot, B., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F. B., Gao, G. F., Gao, J., Garcia, L., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Gautel, M., Gawriluk, T. R., Gegg, M. E., Geng, J., Germain, M., Gestwicki, J. E., Gewirtz, D. A., Ghavami, S., Ghosh, P., Giammarioli, A. M., Giatromanolaki, A. N., Gibson, S. B., Gilkerson, R. W., Ginger, M. L., Ginsberg, H. N., Golab, J., Goligorsky, M. S., Golstein, P., Gomez-Manzano, C., Goncu, E., Gongora, C., Gonzalez, C. D., Gonzalez, R., González-Estévez, C., González-Polo, R. A., Gonzalez-Rey, E., Gorbunov, N. V., Gorski, S., Goruppi, S., Gottlieb, R. A., Gozuacik, D., Granato, G. E., Grant, G. D., Green, K. N., Gregorc, A., Gros, F., Grose, C., Grunt, T. W., Gual, P., Guan, J. L., Guan, K. L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Gustafsson, A. B., Halayko, A. J., Hale, A. N., Halonen, S. K., Hamasaki, M., Han, F., Han, T., Hancock, M. K., Hansen, M., Harada, H., Harada, M., Hardt, S. E., Harper, J. W., Harris, A. L., Harris, J., Harris, S. D., Hashimoto, M., Haspel, J. A., Hayashi, S. I., Hazelhurst, L. A., He, C., He, Y. W., Hébert, M. J., Heidenreich, K. A., Helfrich, M. H., Helgason, G. V., Henske, E. P., Herman, B., Herman, P. K., Hetz, C., Hilfiker, S., Hill, J. A., Hocking, L. J., Hofman, P., Hofmann, T. G., Höhfeld, J., Holyoake, T. L., Hong, M. H., Hood, D. A., Hotamisligil, G. S., Houwerzijl, E. J., Høyer-Hansen, M., Hu, B., Hu, C. A. A., Hu, H. M., Hua, Y., Huang, C., Huang, J., Huang, S., Huang, W. P., Huber, T. B., Huh, W. K., Hung, T. H., Hupp, T. R., Hur, G. M., Hurley, J. B., Hussain, S. N. A., Hussey, P. J., Hwang, J. J., Hwang, S., Ichihara, A., Ilkhanizadeh, S., Inoki, K., Into, T., Iovane, V., Iovanna, J. L., Ip, N. Y., Isaka, Y., Ishida, H., Isidoro, C., Isobe, K. I., Iwasaki, A., Izquierdo, M., Izumi, Y., Jaakkola, P. M., Jäättelä, M., Jackson, G. R., Jackson, W. T., Janji, B., Jendrach, M., Jeon, J. H., Jeung, E. B., Jiang, H., Jiang, H., Jiang, J. X., Jiang, M., Jiang, Q., Jiang, X., Jiménez, A., Jin, M., Jin, S., Joe, C. O., Johansen, T., Johnson, D. E., Johnson, G. V. W., Jones, N. L., Joseph, B., Joseph, S. K., Joubert, A. M., Juhász, G., Juillerat-Jeanneret, L., Jung, C. H., Jung, Y. K., Kaarniranta, K., Kaasik, A., Kabuta, T., Kadowaki, M., Kagedal, K., Kamada, Y., Kaminskyy, V. O., Kampinga, H. H., Kanamori, H., Kang, C., Kang, K. B., Il Kang, K., Kang, R., Kang, Y. A., Kanki, T., Kanneganti, T. D., Kanno, H., Kanthasamy, A. G., Kanthasamy, A., Karantza, V., Kaushal, G. P., Kaushik, S., Kawazoe, Y., Ke, P. Y., Kehrl, J. H., Kelekar, A., Kerkhoff, C., Kessel, D. H., Khalil, H., Kiel, J. A. K. W., Kiger, A. A., Kihara, A., Kim, D. R., Kim, D. H., Kim, D. H., Kim, E. K., Kim, H. R., Kim, J. S., Kim, J. H., Kim, J. C., Kim, J. K., Kim, P. K., Kim, S. W., Kim, Y. S., Kim, Y., Kimchi, A., Kimmelman, A. C., King, J. S., Kinsella, T. J., Kirkin, V., Kirshenbaum, L. A., Kitamoto, K., Kitazato, K., Klein, L., Klimecki, W. 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C., Reggiori, F., Régnier-Vigouroux, A., Reichert, A. S., Reiners, J. J., Reiter, R. J., Ren, J., Revuelta, J. L., Rhodes, C. J., Ritis, K., Rizzo, E., Robbins, J., Roberge, M., Roca, H., Roccheri, M. C., Rocchi, S., Rodemann, H. P., De Córdoba, S. R., Rohrer, B., Roninson, I. B., Rosen, K., Rost-Roszkowska, M. M., Rouis, M., Rouschop, K. M. A., Rovetta, F., Rubin, B. P., Rubinsztein, D. C., Ruckdeschel, K., Rucker, E. B., Rudich, A., Rudolf, E., Ruiz-Opazo, N., Russo, R., Rusten, T. E., Ryan, K. M., Ryter, S. W., Sabatini, D. M., Sadoshima, J., Saha, T., Saitoh, T., Sakagami, H., Sakai, Y., Salekdeh, G. H., Salomoni, P., Salvaterra, P. M., Salvesen, G., Salvioli, R., Sanchez, A. M. J., Sánchez-Alcázar, J. A., Sánchez-Prieto, R., Sandri, M., Sankar, U., Sansanwal, P., Santambrogio, L., Saran, S., Sarkar, S., Sarwal, M., Sasakawa, C., Sasnauskiene, A., Sass, M., Sato, K., Sato, M., Schapira, A. H. V., Scharl, M., Schätzl, H. M., Scheper, W., Schiaffino, S., Schneider, C., Schneider, M. E., Schneider-Stock, R., Schoenlein, P. V., Schorderet, D. F., Schüller, C., Schwartz, G. K., Scorrano, L., Sealy, L., Seglen, P. O., Segura-Aguilar, J., Seiliez, I., Seleverstov, O., Sell, C., Seo, J. B., Separovic, D., Setaluri, V., Setoguchi, T., Settembre, C., Shacka, J. J., Shanmugam, M., Shapiro, I. M., Shaulian, E., Shaw, R. J., Shelhamer, J. H., Shen, H. M., Shen, W. C., Sheng, Z. H., Shi, Y., Shibuya, K., Shidoji, Y., Shieh, J. J., Shih, C. M., Shimada, Y., Shimizu, S., Shintani, T., Shirihai, O. S., Shore, G. C., Sibirny, A. A., Sidhu, S. B., Sikorska, B., Silva-Zacarin, E. C. M., Simmons, A., Simon, A. K., Simon, H. U., Simone, C., Simonsen, A., Sinclair, D. A., Singh, R., Sinha, D., Sinicrope, F. A., Sirko, A., Siu, P. M., Sivridis, E., Skop, V., Skulachev, V. P., Slack, R. S., Smaili, S. S., Smith, D. R., Soengas, M. S., Soldati, T., Song, X., Sood, A. K., Soong, T. W., Sotgia, F., Spector, S. A., Spies, C. D., Springer, W., Srinivasula, S. M., Stefanis, L., Steffan, J. 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X., Zorzano, A., Zschocke, J. & Zuckerbraun, B., Apr 2012, In : Autophagy. 8, 4, p. 445-544 100 p.

Research output: Contribution to journalArticle

Autophagy
Guidelines
Lysosomes
Eukaryota
Research Personnel
2011
87 Citations (Scopus)

Regulation of PINK1-Parkin-mediated mitophagy

Springer, W. & Kahle, P. J., Mar 2011, In : Autophagy. 7, 3, p. 266-278 13 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Parkinson Disease
Autophagy
Nervous System Diseases
Neurodegenerative Diseases
2010
159 Citations (Scopus)

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

Fiesel, F., Voigt, A., Weber, S. S., Van Den Haute, C., Waldenmaier, A., Görner, K., Walter, M., Marlene, A. L., Kern, J. V., Rasse, T. M., Schmidt, T., Springer, W., Kirchner, R., Bonin, M., Neumann, M., Baekelandt, V., Alunni-Fabbroni, M., Schulz, J. B. & Kahle, P. J., Jan 6 2010, In : EMBO Journal. 29, 1, p. 209-221 13 p.

Research output: Contribution to journalArticle

Histone Deacetylases
DNA-Binding Proteins
Down-Regulation
Messenger RNA
RNA
20 Citations (Scopus)

Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans

Cornejo Castro, E. M., Waak, J., Weber, S. S., Fiesel, F., Oberhettinger, P., Schütz, M., Autenrieth, I. B., Springer, W. & Kahle, P. J., May 2010, In : Journal of Neural Transmission. 117, 5, p. 599-604 6 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Innate Immunity
Parkinson Disease
p38 Mitogen-Activated Protein Kinases
Gram-Negative Bacteria
1440 Citations (Scopus)

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F., Rothfuss, O. C., Kahle, P. J. & Springer, W., Feb 2010, In : Nature Cell Biology. 12, 2, p. 119-131 13 p.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channel 1
Mitochondrial Degradation
Ubiquitination
Parkinson Disease
Mitochondria
164 Citations (Scopus)

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

Geisler, S., Holmström, K. M., Treis, A., Skujat, D., Weber, S. S., Fiesel, F., Kahle, P. J. & Springer, W., Oct 1 2010, In : Autophagy. 6, 7, p. 871-878 8 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Parkinson Disease
Mitochondria
Mutation
Autophagy
2009
61 Citations (Scopus)

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

Klein, C. L., Rovelli, G., Springer, W., Schall, C., Gasser, T. & Kahle, P. J., Nov 2009, In : Journal of Neurochemistry. 111, 3, p. 703-715 13 p.

Research output: Contribution to journalArticle

Hominidae
Leucine
Phosphotransferases
Parkinson Disease
Dimerization
2008
56 Citations (Scopus)

Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways

Hasegawa, T., Treis, A., Patenge, N., Fiesel, F., Springer, W. & Kahle, P. J., Jun 2008, In : Journal of Neurochemistry. 105, 5, p. 1700-1715 16 p.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Heat-Shock Proteins
Protein Kinases
Parkinson Disease
Dopamine
2006
14 Citations (Scopus)

Mechanisms and models of α-Synuclein-related neurodegeneration

Springer, W. & Kable, P. J., Sep 2006, In : Current Neurology and Neuroscience Reports. 6, 5, p. 432-436 5 p.

Research output: Contribution to journalArticle

Synucleins
Lewy Body Disease
Genetically Modified Organisms
Multiple System Atrophy
Dopaminergic Neurons
2005
85 Citations (Scopus)

A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress

Springer, W., Hoppe, T., Schmidt, E. & Baumeister, R., Nov 15 2005, In : Human Molecular Genetics. 14, 22, p. 3407-3423 17 p.

Research output: Contribution to journalArticle

Synucleins
Caenorhabditis elegans
Solubility
Parkinsonian Disorders
Mutation
2004
102 Citations (Scopus)

Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans

Hoppe, T., Cassata, G., Barral, J. M., Springer, W., Hutagalung, A. H., Epstein, H. F. & Baumeister, R., Aug 6 2004, In : Cell. 118, 3, p. 337-349 13 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Myosins
Muscle
Animals
HSC70 Heat-Shock Proteins