Research Output per year
Research Output 2004 2019
Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease
Luo, S., Kang, S. S., Wang, Z. H., Liu, X., Day, J. X., Wu, Z., Peng, J., Xiang, D., Springer, W. & Ye, K., Sep 11 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 37, p. 7291-7305 15 p.Research output: Contribution to journal › Article
The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome
Lee, S. B., Kim, J. J., Han, S. A., Fan, Y., Guo, L. S., Aziz, K., Nowsheen, S., Kim, S. S., Park, S. Y., Luo, Q., Chung, J. O., Choi, S. I., Aziz, A., Yin, P., Tong, S. Y., Fiesel, F., Springer, W., Zhang, J. S. & Lou, Z., Aug 1 2019, In : Nature Cell Biology. 21, 8, p. 940-951 12 p.Research output: Contribution to journal › Article
Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease
Hou, X., Fiesel, F., Truban, D., Castanedes Casey, M., Lin, W. L., Soto, A. I., Tacik, P., Rousseau, L. G., Diehl, N. N., Heckman, M. G., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Steele, J. C., Farrer, M. J., Cornejo-Olivas, M., Torres, L., Mata, I. F., Graff Radford, N. R., Wszolek, Z. K. & 4 others, , Jan 1 2018, (Accepted/In press) In : Autophagy.Research output: Contribution to journal › Article
Hexokinases link DJ-1 to the PINK1/parkin pathway
Hauser, D. N., Mamais, A., Conti, M. M., Primiani, C. T., Kumaran, R., Dillman, A. A., Langston, R. G., Beilina, A., Garcia, J. H., Diaz-Ruiz, A., Bernier, M., Fiesel, F., Hou, X., Springer, W., Li, Y., De Cabo, R. & Cookson, M. R., Sep 29 2017, In : Molecular Neurodegeneration. 12, 1, 212.Research output: Contribution to journal › Article
Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy
Fiesel, F., James, E. D., Hudec, R. & Springer, W., Jan 1 2017, In : Oncotarget. 8, 63, p. 106233-106248 16 p.Research output: Contribution to journal › Article
PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival
Lee, Y., Stevens, D. A., Kang, S. U., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G. E., Kang, H., Ham, S., Kam, T. I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F., Springer, W., Dawson, V. L., Shin, J. H. & 1 others, , Jan 24 2017, In : Cell Reports. 18, 4, p. 918-932 15 p.Research output: Contribution to journal › Article
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity
Ando, M., Fiesel, F., Hudec, R., Caulfield, T., Ogaki, K., Górka-Skoczylas, P., Koziorowski, D., Friedman, A., Chen, L., Dawson, V. L., Dawson, T. M., Bu, G. D., Ross, O. A., Wszolek, Z. K. & Springer, W., Apr 24 2017, In : Molecular Neurodegeneration. 12, 1, 32.Research output: Contribution to journal › Article
Waldenstrom macroglobulinemia cells devoid of BTK C481S or CXCR4 WHIM-like mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment
Paulus, A., Akhtar, S., Yousaf, H., Manna, A., Paulus, S. M., Bashir, Y., Caulfield, T., Kuranz-Blake, M., Chitta, K., Wang, X., Asmann, Y., Hudec, R., Springer, W., Ailawadhi, S. & Chanan Khan, A. A., May 26 2017, In : Blood Cancer Journal. 7, 5, 201740.Research output: Contribution to journal › Article
MiR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)
Kim, J., Fiesel, F., Belmonte, K. C., Hudec, R., Wang, W. X., Kim, C., Nelson, P. T., Springer, W. & Kim, J., Jul 26 2016, In : Molecular Neurodegeneration. 11, 1, 55.Research output: Contribution to journal › Article
(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation
Fiesel, F., Ando, M., Hudec, R., Hill, A. R., Castanedes-Casey, M., Caulfield, T., Moussaud-Lamodière, E. L., Stankowski, J. N., Bauer, P. O., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Siuda, J., Chen, L., Dawson, V. L., Dawson, T. M., Wszolek, Z. K., Ross, O. A., Dickson, D. W. & Springer, W., Sep 1 2015, In : EMBO Reports. 16, 9, p. 1114-1130 17 p.Research output: Contribution to journal › Article
Activation of the E3 ubiquitin ligase Parkin
Caulfield, T., Fiesel, F. & Springer, W., Apr 1 2015, In : Biochemical Society Transactions. 43, p. 269-274 6 p.Research output: Contribution to journal › Article
Disease relevance of phosphorylated ubiquitin (p-S65-Ub)
Fiesel, F. & Springer, W., Jan 1 2015, In : Autophagy. 11, 11, p. 2125-2126 2 p.Research output: Contribution to journal › Article
DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients
Lorenzo-Betancor, O., Ogaki, K., Soto-Ortolaza, A. I., Labbe, C., Walton, R. L., Strongosky, A. J., Van Gerpen, J. A., Uitti, R. J., McLean, P. J., Springer, W., Siuda, J., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K., Mccarthy, A., Lynch, T., Puschmann, A., Rektorova, I., Sanotsky, Y. & 10 others, , Sep 1 2015, In : European Journal of Neurology. 22, 9, p. 1323-1325 3 p.Research output: Contribution to journal › Article
Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders
Ogaki, K., Koga, S., Heckman, M. G., Fiesel, F., Ando, M., Labbé, C., Lorenzo-Betancor, O., Moussaud-Lamodière, E. L., Soto-Ortolaza, A. I., Walton, R. L., Strongosky, A. J., Uitti, R. J., McCarthy, A., Lynch, T., Siuda, J., Opala, G., Rudzinska, M., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K. & 12 others, , Dec 8 2015, In : Neurology. 85, 23, p. 2016-2025 10 p.Research output: Contribution to journal › Article
NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1
Shi, J., Fung, G., Deng, H., Zhang, J., Fiesel, F., Springer, W., Li, X. & Luo, H., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1943.Research output: Contribution to journal › Article
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice
Yue, M., Hinkle, K. M., Davies, P., Trushina, E. D., Fiesel, F., Christenson, T. A., Schroeder, A. S., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S. J., Beevers, J. E., Milnerwood, A. J., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D. W., Farrer, M. J. & Melrose, H. L., Jun 1 2015, In : Neurobiology of Disease. 78, p. 172-195 24 p.Research output: Contribution to journal › Article
Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin
Fiesel, F., Caulfield, T., Moussaud-Lamodière, E. L., Ogaki, K., Dourado, D. F. A. R., Flores, S. C., Ross, O. A. & Springer, W., Aug 1 2015, In : Human Mutation. 36, 8, p. 774-786 13 p.Research output: Contribution to journal › Article
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently
Fiesel, F., Moussaud-Lamodière, E. L., Ando, M. & Springer, W., 2014, In : Journal of Cell Science. 127, 16, p. 3488-3504 17 p.Research output: Contribution to journal › Article
Early-onset Parkinson's disease due to PINK1 p.Q456X mutation - Clinical and functional study
Siuda, J., Jasinska-Myga, B., Boczarska-Jedynak, M., Opala, G., Fiesel, F., Moussaud-Lamodière, E. L., Scarffe, L. A., Dawson, V. L., Ross, O. A., Springer, W., Dawson, T. M. & Wszolek, Z. K., Nov 1 2014, In : Parkinsonism and Related Disorders. 20, 11, p. 1274-1278 5 p.Research output: Contribution to journal › Article
Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease
Shannon, B., Soto-Ortolaza, A., Rayaprolu, S., Cannon, H. D., Labbé, C., Benitez, B. A., Choi, J., Lynch, T., Boczarska-Jedynak, M., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Van Gerpen, J. A., Uitti, R. J., Springer, W., Cruchaga, C., Wszolek, Z. K. & Ross, O. A., 2014, In : Neurobiology of Aging. 35, 8Research output: Contribution to journal › Article
Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin
Caulfield, T., Fiesel, F., Moussaud-Lamodière, E. L., Dourado, D. F. A. R., Flores, S. C. & Springer, W., Nov 1 2014, In : PLoS Computational Biology. 10, 11Research output: Contribution to journal › Article
Three families with Perry syndrome from distinct parts of the world
Tacik, P., Fiesel, F., Fujioka, S., Ross, O. A., Pretelt, F., Castañeda Cardona, C., Kidd, A., Hlavac, M., Raizis, A., Okun, M. S., Traynor, S., Strongosky, A. J., Springer, W. & Wszolek, Z. K., 2014, In : Parkinsonism and Related Disorders. 20, 8, p. 884-888 5 p.Research output: Contribution to journal › Article
UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase y regulate TDP-43 protein ubiquitination
Hans, F., Fiesel, F., Strong, J. C., Jackel, S., Rasse, T. M., Geisler, S., Springer, W., Schulz, J. B., Voigt, A. & Kahle, P. J., Jul 4 2014, In : Journal of Biological Chemistry. 289, 27, p. 19164-19179 16 p.Research output: Contribution to journal › Article
LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer's Disease (LOAD)
Lincoln, S., Allen, M., Cox, C. L., Walker, L. P., Malphrus, K., Qiu, Y., Nguyen, T., Rowley, C., Kouri, N., Crook, J., Pankratz, V. S., Younkin, S., Younkin, L., Carrasquillo, M. M., Zou, F., Abdul-Hay, S. O., Springer, W., Sando, S. B., Aasly, J. O., Barcikowska, M. & 8 others, , Jun 4 2013, In : PLoS One. 8, 6, e64164.Research output: Contribution to journal › Article
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Al-Younes, H. M., Al-Zeer, M. A., Albert, M. L., Albin, R. L., Alegre-Abarrategui, J. & 1,249 others, , Apr 2012, In : Autophagy. 8, 4, p. 445-544 100 p.Research output: Contribution to journal › Article
Regulation of PINK1-Parkin-mediated mitophagy
Springer, W. & Kahle, P. J., Mar 2011, In : Autophagy. 7, 3, p. 266-278 13 p.Research output: Contribution to journal › Article
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
Fiesel, F., Voigt, A., Weber, S. S., Van Den Haute, C., Waldenmaier, A., Görner, K., Walter, M., Marlene, A. L., Kern, J. V., Rasse, T. M., Schmidt, T., Springer, W., Kirchner, R., Bonin, M., Neumann, M., Baekelandt, V., Alunni-Fabbroni, M., Schulz, J. B. & Kahle, P. J., Jan 6 2010, In : EMBO Journal. 29, 1, p. 209-221 13 p.Research output: Contribution to journal › Article
Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans
Cornejo Castro, E. M., Waak, J., Weber, S. S., Fiesel, F., Oberhettinger, P., Schütz, M., Autenrieth, I. B., Springer, W. & Kahle, P. J., May 2010, In : Journal of Neural Transmission. 117, 5, p. 599-604 6 p.Research output: Contribution to journal › Article
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F., Rothfuss, O. C., Kahle, P. J. & Springer, W., Feb 2010, In : Nature Cell Biology. 12, 2, p. 119-131 13 p.Research output: Contribution to journal › Article
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
Geisler, S., Holmström, K. M., Treis, A., Skujat, D., Weber, S. S., Fiesel, F., Kahle, P. J. & Springer, W., Oct 1 2010, In : Autophagy. 6, 7, p. 871-878 8 p.Research output: Contribution to journal › Article
Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment
Klein, C. L., Rovelli, G., Springer, W., Schall, C., Gasser, T. & Kahle, P. J., Nov 2009, In : Journal of Neurochemistry. 111, 3, p. 703-715 13 p.Research output: Contribution to journal › Article
Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways
Hasegawa, T., Treis, A., Patenge, N., Fiesel, F., Springer, W. & Kahle, P. J., Jun 2008, In : Journal of Neurochemistry. 105, 5, p. 1700-1715 16 p.Research output: Contribution to journal › Article
Mechanisms and models of α-Synuclein-related neurodegeneration
Springer, W. & Kable, P. J., Sep 2006, In : Current Neurology and Neuroscience Reports. 6, 5, p. 432-436 5 p.Research output: Contribution to journal › Article
A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress
Springer, W., Hoppe, T., Schmidt, E. & Baumeister, R., Nov 15 2005, In : Human Molecular Genetics. 14, 22, p. 3407-3423 17 p.Research output: Contribution to journal › Article
Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans
Hoppe, T., Cassata, G., Barral, J. M., Springer, W., Hutagalung, A. H., Epstein, H. F. & Baumeister, R., Aug 6 2004, In : Cell. 118, 3, p. 337-349 13 p.Research output: Contribution to journal › Article