Thomas Caulfield, PhD

Associate Consultant, Associate Consultant

  • 1949 Citations
  • 22 Scopus h-Index
20062019
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Fingerprint Dive into the research topics where Thomas Caulfield is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Proteins Medicine & Life Sciences
Waldenstrom Macroglobulinemia Medicine & Life Sciences
Ubiquitin Medicine & Life Sciences
Ubiquitin-Protein Ligases Medicine & Life Sciences
Molecular Dynamics Simulation Medicine & Life Sciences
Exome Medicine & Life Sciences
Informatics Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences

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Research Output 2006 2019

  • 1949 Citations
  • 22 Scopus h-Index
  • 47 Article
  • 3 Review article
  • 1 Chapter
  • 1 Letter

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yamazaki, Y., Zhao, N., Caulfield, T., Liu, C-C. & Bu, G. D., Sep 1 2019, In : Nature Reviews Neurology. 15, 9, p. 501-518 18 p.

Research output: Contribution to journalReview article

Apolipoproteins E
Alzheimer Disease
Amyloid
Alleles
Pathology
1 Citation (Scopus)

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin

Cohen, I., Coban, M., Shahar, A., Sankaran, B., Hockla, A., Lacham, S., Caulfield, T., Radisky, E. S. & Papo, N., Jan 1 2019, In : Journal of Biological Chemistry. 294, 13, p. 5105-5120 16 p.

Research output: Contribution to journalArticle

Proteolysis
Serine Proteinase Inhibitors
Human Engineering
Disulfides
Peptide Hydrolases

Genomic observations of a rare/pathogenic SMAD3 variant in Loeys–Dietz syndrome 3 confirmed by protein informatics and structural investigations

Richter, J. E., Samreen, A., Vadlamudi, C., Helmi, H., Mohammad, A. N., Wierenga, K., Hines, S., Atwal, P. S. & Caulfield, T., May 1 2019, In : Medicina (Lithuania). 55, 5, 137.

Research output: Contribution to journalArticle

Open Access
Informatics
Virulence
Uvula
Marfan Syndrome
Proteins
1 Citation (Scopus)

Integrative data fusion for comprehensive assessment of a novel CHEK2 variant using combined genomics, imaging, and functional-structural assessments via protein informatics

Hines, S. L., Mohammad, A. N., Jackson, J., Macklin, S. & Caulfield, T., Jan 1 2019, In : Molecular Omics. 15, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

Informatics
Data fusion
Genomics
Imaging techniques
Proteins
2 Citations (Scopus)

Protein informatics combined with multiple data sources enriches the clinical characterization of novel TRPV4 variant causing an intermediate skeletal dysplasia

Hines, S. L., Richter, J. E., Mohammad, A. N., Mahim, J., Atwal, P. S. & Caulfield, T., Jan 1 2019, In : Molecular Genetics and Genomic Medicine. e566.

Research output: Contribution to journalArticle

Informatics
Information Storage and Retrieval
Proteins
Exome
Transient Receptor Potential Channels