Thomas Caulfield, PhD

Associate Consultant, Associate Consultant

  • 2378 Citations
  • 24 Scopus h-Index
20062020

Research output per year

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Research Output

  • 2378 Citations
  • 24 Scopus h-Index
  • 54 Article
  • 3 Review article
  • 1 Chapter
  • 1 Letter
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Article
2020

Examination of Molecular Effects of MYLK Deletion in a Patient with Extensive Aortic, Carotid, and Abdominal Dissections That Underlie the Genetic Dysfunction

MacKlin, S. K., Bruno, K. A., Vadlamudi, C., Helmi, H., Samreen, A., Mohammad, A. N., Hines, S., Atwal, P. S. & Caulfield, T. R., 2020, In : Case Reports in Medicine. 2020, 5108052.

Research output: Contribution to journalArticle

Open Access

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Kojima, Y., Machida, Y., Palani, S., Caulfield, T. R., Radisky, E. S., Kaufmann, S. H. & Machida, Y. J., Dec 1 2020, In : Nature communications. 11, 1, 1318.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Functional Analysis of the SIM1 Variant p.G715V in 2 Patients With Obesity

Blackburn, P. R., Sullivan, A. E., Gerassimou, A. G., Kleinendorst, L., Bersten, D. C., Cooiman, M., Harris, K. G., Wierenga, K. J., Klee, E. W., van Gerpen, J. A., Ross, O. A., van Haelst, M. M., Whitelaw, M. L., Caulfield, T. R. & Atwal, P. S., Jan 1 2020, In : The Journal of clinical endocrinology and metabolism. 105, 1

Research output: Contribution to journalArticle

1 Scopus citations

Molecular inhibitor of QSOX1 suppresses tumor growth in vivo

Fifield, A. L., Hanavan, P. D., Faigel, D. O., Sergienko, E., Bobkov, A., Meurice, N., Petit, J. L., Polito, A., Caulfield, T. R., Castle, E. P., Copland, J. A., Mukhopadhyay, D., Pal, K., Dutta, S. K., Luo, H., Ho, T. H. & Lake, D. F., 2020, In : Molecular cancer therapeutics. 19, 1, p. 112-122 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Design and Evaluation of PEGylated Liposomal Formulation of a Novel Multikinase Inhibitor for Enhanced Chemosensitivity and Inhibition of Metastatic Pancreatic Ductal Adenocarcinoma

Madamsetty, V. S., Pal, K., Dutta, S. K., Wang, E., Thompson, J. R., Banerjee, R. K., Caulfield, T. R., Mody, K., Yen, Y., Mukhopadhyay, D. & Huang, H. S., Oct 16 2019, In : Bioconjugate Chemistry. 30, 10, p. 2703-2713 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Development of multi-drug loaded PEGylated nanodiamonds to inhibit tumor growth and metastasis in genetically engineered mouse models of pancreatic cancer

Madamsetty, V. S., Pal, K., Keshavan, S., Caulfield, T. R., Dutta, S. K., Wang, E., Fadeel, B. & Mukhopadhyay, D., Dec 7 2019, In : Nanoscale. 11, 45, p. 22006-22018 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin

Cohen, I., Coban, M., Shahar, A., Sankaran, B., Hockla, A., Lacham, S., Caulfield, T. R., Radisky, E. S. & Papo, N., Mar 29 2019, In : Journal of Biological Chemistry. 294, 13, p. 5105-5120 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Genomic observations of a rare/pathogenic SMAD3 variant in Loeys–Dietz syndrome 3 confirmed by protein informatics and structural investigations

Richter, J. E., Samreen, A., Vadlamudi, C., Helmi, H., Mohammad, A. N., Wierenga, K., Hines, S., Atwal, P. S. & Caulfield, T. R., May 2019, In : Medicina (Lithuania). 55, 5, 137.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Integrative data fusion for comprehensive assessment of a novel CHEK2 variant using combined genomics, imaging, and functional-structural assessments via protein informatics

Hines, S. L., Mohammad, A. N., Jackson, J., Macklin, S. & Caulfield, T., Jan 1 2019, In : Molecular Omics. 15, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Molecular dynamics simulations suggest a non-doublet decoding model of –1 frameshifting by tRNAser3

Caulfield, T., Coban, M., Tek, A. & Flores, S. C., Nov 2019, In : Biomolecules. 9, 11, 745.

Research output: Contribution to journalArticle

Open Access

Protein informatics combined with multiple data sources enriches the clinical characterization of novel TRPV4 variant causing an intermediate skeletal dysplasia

Hines, S. L., Richter, J. E., Mohammad, A. N., Mahim, J., Atwal, P. S. & Caulfield, T., Jan 1 2019, In : Molecular Genetics and Genomic Medicine. e566.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

von Roemeling, C. A., Caulfield, T. R., Marlow, L., Bok, I., Wen, J., Miller, J. L., Hughes, R., Hazlehurst, L., Pinkerton, A. B., Radisky, D. C., Tun, H. W., Kim, Y. S. B., Lane, A. L. & Copland, J. A., 2018, In : Oncotarget. 9, 1, p. 3-20 18 p.

Research output: Contribution to journalArticle

7 Scopus citations

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity

Bogaert, E., Boeynaems, S., Kato, M., Guo, L., Caulfield, T., Steyaert, J., Scheveneels, W., Wilmans, N., Haeck, W., Hersmus, N., Schymkowitz, J., Rousseau, F., Shorter, J., Callaerts, P., Robberecht, W., Van Damme, P. & Van Den Bosch, L., Jul 17 2018, In : Cell Reports. 24, 3, p. 529-537.e4

Research output: Contribution to journalArticle

18 Scopus citations

Personalized molecular modeling for pinpointing associations of protein dysfunction and variants associated with hereditary cancer syndromes

Macklin, S., Mohammed, A., Jackson, J., Hines, S. L., Atwal, P. S. & Caulfield, T., Jan 1 2018, (Accepted/In press) In : Molecular Genetics and Genomic Medicine.

Research output: Contribution to journalArticle

1 Scopus citations

Protein modeling and clinical description of a novel in-frame GLB1 deletion causing GM1 gangliosidosis type II

Richter, J. E., Zimmermann, M. T., Blackburn, P. R., Mohammad, A. N., Klee, E. W., Pollard, L. M., Macmurdo, C. F., Atwal, P. S. & Caulfield, T. R., Nov 2018, In : Molecular Genetics and Genomic Medicine. 6, 6, p. 1229-1235 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Protein molecular modeling shows residue T599 is critical to wild-type function of POLG and description of a novel variant associated with the SANDO phenotype

Richter, J. E., Robles, H. G., Mauricio, E., Mohammad, A., Atwal, P. S. & Caulfield, T. R., Apr 5 2018, In : Human Genome Variation. 5, 18016.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Protein molecular modeling techniques investigating novel TAB2 variant R347X causing cardiomyopathy and congenital heart defects in multigenerational family

Caulfield, T. R., Richter, J. E., Brown, E. E., Mohammad, A. N., Judge, D. P. & Atwal, P. S., Jul 2018, In : Molecular Genetics and Genomic Medicine. 6, 4, p. 666-672 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

TRIO gene segregation in a family with cerebellar ataxia

Hanna Al Shaikh, R., Caulfield, T., Strongosky, A. J., Matthew, M., Jansen-West, K. R., Prudencio, M., Fryer, J. D., Petrucelli, L., Uitti, R. J. & Wszolek, Z. K., Nov 1 2018, In : Neurologia i neurochirurgia polska. 52, 6, p. 743-749 7 p.

Research output: Contribution to journalArticle

2017

A novel splice site variant in CYP11A1 in trans with the p.E314K variant in a male patient with congenital adrenal insufficiency

Lara-Velazquez, M., Perdomo-Pantoja, A., Blackburn, P. R., Gass, J. M., Caulfield, T. & Atwal, P. S., Jan 1 2017, In : Molecular Genetics and Genomic Medicine. 5, 6, p. 781-787 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism

Puschmann, A., Fiesel, F. C., Caulfield, T. R., Hudec, R., Ando, M., Truban, D., Hou, X., Ogaki, K., Heckman, M. G., James, E. D., Swanberg, M., Jimenez-Ferrer, I., Hansson, O., Opala, G., Siuda, J., Boczarska-Jedynak, M., Friedman, A., Koziorowski, D., Rudzińska-Bar, M., Aasly, J. O. & 13 others, Lynch, T., Mellick, G. D., Mohan, M., Silburn, P. A., Sanotsky, Y., Vilariño-Güell, C., Farrer, M. J., Chen, L., Dawson, V. L., Dawson, T. M., Wszolek, Z. K., Ross, O. A. & Springer, W., 2017, In : Brain. 140, 1, p. 98-117 20 p.

Research output: Contribution to journalArticle

57 Scopus citations

Multifaceted peptide assisted one-pot synthesis of gold nanoparticles for plectin-1 targeted gemcitabine delivery in pancreatic cancer

Pal, K., Al-Suraih, F., Gonzalez-Rodriguez, R., Dutta, S. K., Wang, E., Kwak, H. S., Caulfield, T. R., Coffer, J. L. & Bhattacharya, S., Oct 28 2017, In : Nanoscale. 9, 40, p. 15622-15634 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Small molecule inhibitors of mesotrypsin from a structurebased docking screen

Kayode, O., Huang, Z., Soares, A. S., Caulfield, T. R., Dong, Z., Bode, A. M. & Radisky, E. S., May 2017, In : PloS one. 12, 5, e0176694.

Research output: Contribution to journalArticle

2 Scopus citations

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Ando, M., Fiesel, F. C., Hudec, R., Caulfield, T. R., Ogaki, K., Górka-Skoczylas, P., Koziorowski, D., Friedman, A., Chen, L., Dawson, V. L., Dawson, T. M., Bu, G., Ross, O. A., Wszolek, Z. K. & Springer, W., Apr 24 2017, In : Molecular neurodegeneration. 12, 1, 32.

Research output: Contribution to journalArticle

19 Scopus citations
19 Scopus citations
2016

An acrobatic substrate metamorphosis reveals a requirement for substrate conformational dynamics in trypsin proteolysis

Kayode, O., Wang, R., Pendlebury, D. F., Cohen, I., Henin, R. D., Hockla, A., Soares, A. S., Papo, N., Caulfield, T. R. & Radisky, E. S., Dec 16 2016, In : Journal of Biological Chemistry. 291, 51, p. 26304-26319 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells

Paulus, A., Akhtar, S., Caulfield, T. R., Samuel, K., Yousaf, H., Bashir, Y., Paulus, S. M., Tran, D., Hudec, R., Cogen, D., Jiang, J., Edenfield, B., Novak, A., Ansell, S. M., Witzig, T., Martin, P., Coleman, M., Roy, V., Ailawadhi, S., Chitta, K. & 2 others, Linder, S. & Chanan-Khan, A., Nov 4 2016, In : Blood cancer journal. 6, 11, e492.

Research output: Contribution to journalArticle

23 Scopus citations
2015

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

Fiesel, F. C., Ando, M., Hudec, R., Hill, A. R., Castanedes-Casey, M., Caulfield, T. R., Moussaud-Lamodière, E. L., Stankowski, J. N., Bauer, P. O., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Siuda, J., Chen, L., Dawson, V. L., Dawson, T. M., Wszolek, Z. K., Ross, O. A., Dickson, D. W. & Springer, W., Sep 1 2015, In : EMBO Reports. 16, 9, p. 1114-1130 17 p.

Research output: Contribution to journalArticle

65 Scopus citations

Activation of the E3 ubiquitin ligase Parkin

Caulfield, T., Fiesel, F. & Springer, W., Apr 1 2015, In : Biochemical Society Transactions. 43, p. 269-274 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors

Abdul-Hay, S. O., Bannister, T. D., Wang, H., Cameron, M. D., Caulfield, T., Masson, A., Bertrand, J., Howard, E. A., McGuire, M. P., Crisafulli, U., Rosenberry, T. R., Topper, C. L., Thompson, C. R., Schürer, S. C., Madoux, F., Hodder, P. & Leissring, M. A., Dec 18 2015, In : ACS Chemical Biology. 10, 12, p. 2716-2724 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

Fiesel, F., Caulfield, T., Moussaud-Lamodière, E. L., Ogaki, K., Dourado, D. F. A. R., Flores, S. C., Ross, O. A. & Springer, W., Aug 1 2015, In : Human Mutation. 36, 8, p. 774-786 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15

Wang, X., D'Arcy, P., Caulfield, T., Paulus, A., Chitta, K., Mohanty, C., Gullbo, J., Chanan Khan, A. A. & Linder, S., Nov 1 2015, In : Chemical Biology and Drug Design. 86, 5, p. 1036-1048 13 p.

Research output: Contribution to journalArticle

48 Scopus citations
36 Scopus citations
2014

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

Zhang, Y. J., Jansen-West, K., Xu, Y. F., Gendron, T. F., Bieniek, K. F., Lin, W. L., Sasaguri, H., Caulfield, T., Hubbard, J., Daughrity, L., Chew, J., Belzil, V. V., Prudencio, M., Stankowski, J. N., Castanedes-Casey, M., Whitelaw, E., Ash, P. E. A., DeTure, M., Rademakers, R., Boylan, K. B. & 2 others, Dickson, D. W. & Petrucelli, L., Jan 1 2014, In : Acta neuropathologica. 128, 4, p. 505-524 20 p.

Research output: Contribution to journalArticle

159 Scopus citations

Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

Chitta, K., Paulus, A., Caulfield, T., Akhtar, S., Blake, M. K. K., Ailawadhi, S., Knight, J., Heckman, M. G., Pinkerton, A. & Chanan Khan, A. A., Jan 1 2014, In : Blood Cancer Journal. 4, 11, e260.

Research output: Contribution to journalArticle

14 Scopus citations

Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin

Caulfield, T. R., Fiesel, F. C., Moussaud-Lamodière, E. L., Dourado, D. F. A. R., Flores, S. C. & Springer, W., Nov 1 2014, In : PLoS computational biology. 10, 11

Research output: Contribution to journalArticle

56 Scopus citations

Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency

Lee, W. C., Almeida, S., Prudencio, M., Caulfield, T. R., Zhang, Y. J., Tay, W. M., Bauer, P. O., Chew, J., Sasaguri, H., Jansen-west, K. R., Gendron, T. F., Stetler, C. T., Finch, N. C., Mackenzie, I. R., Rademakers, R., Gao, F. B. & Petrucelli, L., Mar 1 2014, In : Human molecular genetics. 23, 6, p. 1467-1478 12 p., ddt534.

Research output: Contribution to journalArticle

49 Scopus citations
2013

An integrated approach to the discovery of potent agelastatin A analogues for brain tumors: Chemical synthesis and biological, physicochemical and CNS pharmacokinetic analyses

Li, Z., Shigeoka, D., Caulfield, T. R., Kawachi, T., Qiu, Y., Kamon, T., Arai, M., Tun, H. W. & Yoshimitsu, T., Jul 1 2013, In : MedChemComm. 4, 7, p. 1093-1098 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS

Gendron, T. F., Bieniek, K. F., Zhang, Y. J., Jansen-West, K., Ash, P. E. A., Caulfield, T., Daughrity, L., Dunmore, J. H., Castanedes-Casey, M., Chew, J., Cosio, D. M., Van Blitterswijk, M., Lee, W. C., Rademakers, R., Boylan, K. B., Dickson, D. W. & Petrucelli, L., Dec 1 2013, In : Acta neuropathologica. 126, 6, p. 829-844 16 p.

Research output: Contribution to journalArticle

258 Scopus citations

Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation

Batra, J., Szabó, A., Caulfield, T. R., Soares, A. S., Sahin-Tóth, M. & Radisky, E. S., Apr 5 2013, In : Journal of Biological Chemistry. 288, 14, p. 9848-9859 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity

Abdul-Hay, S. O., Lane, A. L., Caulfield, T. R., Claussin, C., Bertrand, J., Masson, A., Choudhry, S., Fauq, A. H., Maharvi, G. M. & Leissring, M. A., Mar 28 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2246-2255 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma

Von Roemeling, C. A., Marlow, L. A., Wei, J. J., Cooper, S. J., Caulfield, T. R., Wu, K., Tan, W. W., Tun, H. W. & Copland, J. A., May 1 2013, In : Clinical Cancer Research. 19, 9, p. 2368-2380 13 p.

Research output: Contribution to journalArticle

102 Scopus citations

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

Zhang, Y. J., Caulfield, T., Xu, Y. F., Gendron, T. F., Hubbard, J., Stetler, C., Sasaguri, H., Whitelaw, E. C., Cai, S., Lee, W. C. & Petrucelli, L., Aug 2013, In : Human molecular genetics. 22, 15, p. 3112-3122 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS

Ash, P. E. A., Bieniek, K. F., Gendron, T. F., Caulfield, T., Lin, W. L., DeJesus-Hernandez, M., Van Blitterswijk, M. M., Jansen-West, K., Paul, J. W., Rademakers, R., Boylan, K. B., Dickson, D. W. & Petrucelli, L., Feb 20 2013, In : Neuron. 77, 4, p. 639-646 8 p.

Research output: Contribution to journalArticle

580 Scopus citations
2012

Inhibition of prohormone convertases PC1/3 and PC2 by 2,5- dideoxystreptamine derivatives

Vivoli, M., Caulfield, T. R., Martínez-Mayorga, K., Johnson, A. T., Jiao, G. S. & Lindberg, I., Mar 2012, In : Molecular pharmacology. 81, 3, p. 440-454 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Motion of transfer RNA from the A/T state into the A-site using docking and simulations

Caulfield, T. & Devkota, B., Nov 2012, In : Proteins: Structure, Function and Bioinformatics. 80, 11, p. 2489-2500 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Pharmacokinetics of Agelastatin A in the central nervous system

Li, Z., Kamon, T., Personett, D. A., Caulfield, T., Copland, J. A., Yoshimitsu, T. & Tun, H. W., Feb 1 2012, In : MedChemComm. 3, 2, p. 233-237 5 p.

Research output: Contribution to journalArticle

11 Scopus citations
4 Scopus citations
2011

Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of some benzimidazole derivatives with trichomonicidal activity

Pérez-Villanueva, J., Medina-Franco, J. L., Caulfield, T. R., Hernández-Campos, A., Hernández-Luis, F., Yépez-Mulia, L. & Castillo, R., Aug 1 2011, In : European Journal of Medicinal Chemistry. 46, 8, p. 3499-3508 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Examinations of tRNA range of motion using simulations of cryo-EM microscopy and X-ray data

Caulfield, T. R., Devkota, B. & Rollins, G. C., 2011, In : Journal of Biophysics. 219515.

Research output: Contribution to journalArticle

30 Scopus citations

Integrating virtual screening and combinatorial chemistry for accelerated drug discovery

López-Vallejo, F., Caulfield, T., Martínez-Mayorga, K., Giulianotti, M. A., Nefzi, A., Houghten, R. A. & Medina-Franco, J. L., Jul 1 2011, In : Combinatorial Chemistry and High Throughput Screening. 14, 6, p. 475-487 13 p.

Research output: Contribution to journalArticle

60 Scopus citations