• 9443 Citations
  • 59 h-Index
1974 …2020
If you made any changes in Pure, your changes will be visible here soon.

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 1 Similar Profiles
Cholinergic Receptors Medicine & Life Sciences
Nicotinic Receptors Medicine & Life Sciences
Congenital Myasthenic Syndromes Medicine & Life Sciences
Mutation Medicine & Life Sciences
Binding Sites Medicine & Life Sciences
Acetylcholine Medicine & Life Sciences
Cysteine Loop Ligand-Gated Ion Channel Receptors Medicine & Life Sciences
Ligands Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1985 2020

Nicotinic Receptors
Calcium
Divalent Cations
Cognition Disorders
Drug Design

Allosteric Coupling in Homomeric Cys-loop Receptors

Sine, S. M.

National Institutes of Health

7/15/066/30/11

Project: Research projectResearch Project

Cysteine Loop Ligand-Gated Ion Channel Receptors
Neurotransmitter Receptor
Binding Sites
Pharmaceutical Preparations
Anti-Anxiety Agents

STRUCTURE AND BIOPHYSICS OF THE ACETYLCHOLINE RECEPTOR

Sine, S. M.

National Institutes of Health

9/1/924/30/18

Project: Research projectMethod to Extend Research in Time (MERIT) Award, Research Project

Cholinergic Receptors
Neurotransmitter Receptor
Congenital Myasthenic Syndromes
Neurotransmitter Agents
Ion Channels

CHEMICAL RECEPTOR EXPRESSION

Sine, S. M. & Dionne, V.

National Institutes of Health

9/29/878/31/03

Project: Research projectSmall Research Grants

Cholinergic Receptors
Ion Channels
Neurotransmitter Agents
Receptors, Serotonin, 5-HT3
Nicotinic Receptors

NATIONAL BIOMEDICAL NMR RESOURCE AT MADISON

Prendergast, F. G., Sine, S. M., Nmrfam, [. V., Gellman, S. H., Handelsman, J. O., Gesteland, R. A. Y., [No Value], H. H., Nealey, P. F., Palmer, A. G., De Pablo, J. J., Tang, P. E. I., Berg, J., Escalante, J., Vickery, L., Zhou, M., Malecki, M., Fry, C., Dejesus, O., Pflueger, F., Parkin, K., Varian, V., Gracz, H., Kleps, R., Berg, J., Escalante, J., Zhou, M., Malecki, M., Parkin, K., Varian, V., Gracz, H., Kleps, R., Vickery, L., Downs, D. M., Pflueger, F., Fillingame, R., Fry, C., Klein, B., Laurence, J., Perczel, A., Griffith, B., Blackwell, H. E., Rankin, S., Gellman, S. H., Frey, P. D., Sigel, R., Jeffries, T. W., van Doren, S., Mujeeb, A., Wand, J., Varani, G., Murphy, W., Walters, K., Oswald, R., Matthews, B. A., Skrynnikov, N., Matsuo, H., Anderson, M., Vierstra, R., Andes, A., Huang, R. C., Ahlquist, P. G., Lan, Q. U. E., Kent, S. B. H., Smith, J. L., Gourse, R. L., Walters, K. J., Komives, E. A., Ntambi, J. A., Murphy, J. R., Lindroth, A. N. N., Rouho, A., Johnson, D. G., [No Value], B. G., Vugmeyster, L., Roucho, A., Schram, V., Halkides, C., Nicholson, L., Angeletti, R., Bolton, P., McKay, D., James, T., Schroeder, C., Erlichman, J., Tsai, M., Nair, H. K., Charles, S., Roberts, J., Shi-Jiang, L., Almo, S., Tsang, P., Feigon, J., Klein, S., Arus, C., Clancy, P., Young, R., Cheng, T., Ulrich, E., Girvin, M. E., Kiessling, L., Satterlee, J., Chobanian, M., Harsy, S., Honggao, Y., Russu, I., Agris, P., Fillingame, R., Gunasekaran, S., Weber, D. J., Wand, A., Record, M. T., Wemmer, D., Bleam, W., Stone, M., Swaminathan, S., Donohue, T., Westler, W., Nmrfam Staff, [. V., Raines, R., Dzakula, Z., Mooberry, E., Anderson, L., Triplett, E., Gilboe, D., Ralph, J., Elfarra, A., Liao, X., Lightfoot, E., Cleland, W. W., Lemaster, D., De Luca, H., Schleucher, J., Downs, D. M., Chien, H., van Doren, S., Frey, P. A., Volkman, B., [No Value], B. G., Paaren, H., Anderson, M., Reddy, V., Deluca, P., Dejesus, O. T., Tran, C., Reed, G., Ruoho, A. E., [No Value], J. H., Bax, A. D., Markley, J., Escalante, J., Mosher, D. F., Butcher, S., Loria, J., Roucho, A., Mosher, D. F., Thorson, J. S., Vugmeyster, L., [No Value], B. G., Cavagnero, S., Sem, D., Halkides, C., McKay, D., Cheng, T., Gunasekaran, S., Ralph, J., De Luca, H., Anderson, M., Schram, V., Nicholson, L., Angeletti, R., Schroeder, C., Erlichman, J., Tsai, M., Nair, H. K., Charles, S., Roberts, J., Shi-Jiang, L., Almo, S., Tsang, P., Feigon, J., Klein, S., Arus, C., Clancy, P., Girvin, M. E., Kiessling, L., Chobanian, M., Harsy, S., Honggao, Y., Russu, I., Agris, P., Fillingame, R., Weber, D. J., Wand, A., Record, M. T., Wemmer, D., Bleam, W., Stone, M., Swaminathan, S., Donohue, T., Nmrfam Staff, [. V., Dzakula, Z., Mooberry, E., Anderson, L., Liao, X., Lightfoot, E., Cleland, W. W., Lemaster, D., Schleucher, J., Downs, D. M., Chien, H., van Doren, S., Frey, P. A., Volkman, B., [No Value], B. G., Paaren, H., Reddy, V., Dejesus, O. T., Tran, C., Reed, G., Ruoho, A. E., [No Value], J. H., Bax, A. D., Zuiderweg, E., Dratz, E., Nair, H., Agard, D., Puglisi, R., Nmrfam, [. V., Dakula, D., Young, R., Bashir, M., Nikolau, B., Miziorko, H., Pardi, A., Abildgaard, F., Stockman, B., Kasper, C., Metzler, D., Serpersu, E., Dumesic, J., Anthonsen, H., Baldwin, R., Filligname, R., Morrissey, M., Gellman, S. H., Guiles, R., Weiss, M. A., Hutchinson, C., Royer, C., Fitzpatrick, P., Menon, A., Neuhaus, F., Steele, J., Goldman, I., Handelsman, J. O., Burnette, R., Redwine, D., Stone, C., Gesteland, R. A. Y., Escalante, J., Northrop, D., Schroeder, C., Banfield, J., Fesik, S., Gauthier, J., Rule, G., Helmke, P., Bushweller, J. H., Walker, J., [No Value], H. H., Dratz, E., Feigon, J., Sundquist, W., Dewerd, L., Ganther, H., Mosher, D. F., Kenealy, W., McGee, W., Harsy, S., Sussman, M., Gmeiner, W., Nealey, P. F., Hemmi, H., Honggao, Y., Palmer, A. G., Dzakula, R., Bashir, M., Agris, P., Reed, J., De Pablo, J. J., Bullerjahn, G., Pariza, M., Fillingame, R., Chambliss, G., Hinck, A., Margolis, F., Johnson, M., Driscoll, J., Qureshi, N., Pyle, A. M., Tang, P. E. I., Burgess, R., Phillips, G. N., Berg, J., Malecki, M., Escalante, J., Vickery, L., Zhou, M., Sidhu, A., Butcher, S., Fry, C., Cavagnero, S., Khorasanizadeh, S., Stauffacher, C. V., Pflueger, F., Fillingame, R., Alexandrescu, A., Sem, D., Parkin, K., Varian, V., Gracz, H., Lutsenko, S., Kleps, R., Phillips, G. N., Berg, J., Malecki, M., Escalante, J., Liao, X., Zhou, M., Sidhu, A., Khorasanizadeh, S., Stauffacher, C. V., Alexandrescu, A., Reed, G., Parkin, K., Varian, V., Gracz, H., Lutsenko, S., Kleps, R., Vickery, L., Garfinkel, M., Downs, D. M., [No Value], B. G., Pflueger, F., Fillingame, R., Sem, D., Fry, C., De Luca, H., Cavagnero, S., Ralph, J., Cleland, W. W., Butcher, S., Zuiderweg, E., Loria, J., Santalucia, J., Klein, B., Laurence, J., Perczel, A., Griffith, B., Blackwell, H. E., Rankin, S., Gellman, S. H., Hellekant, G., van Doren, S., Frey, P. D., Gizachew, D., Sigel, R., Kwang, H., Jeffries, T. W., Mujeeb, A., Wand, J., Varani, G., Bushweller, J. H., Roucho, A., Murphy, W., Walters, K., Mosher, D. F., Oswald, R., Thorson, J. S., Matthews, B. A., Skrynnikov, N., Matsuo, H., Kalodimos, C., Anderson, M., Kiessling, L., B Craig, L., Veglia, G., Assadi-Porter, F., Vierstra, R., Andes, A., Rajagopal, P., Huang, R. C., Dunham, S., Walters, K., Vugmeyster, L., Parson, W., Ahlquist, P. G., Keck, J., Sorgen, P., Craig, E., Weibel, D. B., Lan, Q. U. E., Ensign, J., Escalante, J., Frihart, C., Dmitriev, O., Mari, F., Rivera, E., Kent, S. B. H., van Doren, S., Denu, J., Smith, J. L., Gourse, R. L., Roucho, A., Loria, J., Cook, M., Walters, K. J., Deluca, H., Xie, J., Ansari, A., Mosher, D. F., Andes, D., Dixon, J., [No Value], B. G., Michael, C., Zimei, B., Attie, A., Marino, J. P., Wildman, K. A. H., Whittaker, J., Komives, E. A., Klein, B. S., Schroeder, F., Fry, C., Keutsch, F., Ntambi, J. A., Abraham, B., Yawen, B., Murphy, J. R., Ralph, J., Degrado, W., Lindroth, A. N. N., Wadsworth, K., Thorson, J. S., Hamann, M., Cavagnero, S., Bugni, T., Vugmeyster, L., Rouho, A., Wang, S., Sem, D., Johnson, D. G., Rayment, I., Raines, R., Westler, W., Nmrfam Staff, Nmrfam & Klein, B.

National Institutes of Health

7/1/852/28/15

Project: Research projectBiotechnology Resource Grants

Spectrometers
Biochemistry
Magnetic resonance
Macromolecules
Nuclear magnetic resonance

Research Output 1974 2018

  • 9443 Citations
  • 59 h-Index
  • 146 Article
  • 2 Conference contribution
  • 1 Comment/debate

Full and partial agonists evoke distinct structural changes in opening the muscle acetylcholine receptor channel

Mukhtasimova, N. & Sine, S. M., May 1 2018, In : Journal of General Physiology. 150, 5, p. 713-729 17 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Cysteine
Muscles
Cholinergic Agonists
Choline
10 Citations

Nicotinic acetylcholine receptors at the single-channel level

Bouzat, C. & Sine, S. M., 2017, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Nicotinic Receptors
Cholinergic Receptors
Patch-Clamp Techniques
Nobel Prize
Ligand-Gated Ion Channels
14 Citations

α 4β2Nicotinic Acetylcholine Receptors; relationships between subunit stoichiometry and function at the single channel level

Mazzaferro, S., Bermudez, I., Sine, S. M. & Stephenson, F. A., Feb 17 2017, In : Journal of Biological Chemistry. 292, 7, p. 2729-2740 12 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Stoichiometry
Nociception
Nicotinic Receptors
Nervous System Diseases
12 Citations

Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR

Mukhtasimova, N., daCosta, C. J. B. & Sine, S. M., 2016, In : Journal of General Physiology. 148, 1, p. 43-63 21 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Muscles
Noise
Cysteine Loop Ligand-Gated Ion Channel Receptors
Vertebrates
3 Citations

Investigation of congenital myasthenia reveals functional asymmetry of invariant acetylcholine receptor (AChR) cys-loop aspartates

Shen, X. M., Brengman, J., Neubauer, D., Sine, S. M. & Engel, A. G., Feb 12 2016, In : Journal of Biological Chemistry. 291, 7, p. 3291-3301 11 p.

Research output: Contribution to journalArticle

Congenital Myasthenic Syndromes
Cholinergic Receptors
Aspartic Acid
Cysteine Loop Ligand-Gated Ion Channel Receptors
Mutation