Projects per year
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Cholinergic Receptors
Medicine & Life Sciences
Nicotinic Receptors
Medicine & Life Sciences
Congenital Myasthenic Syndromes
Medicine & Life Sciences
Mutation
Medicine & Life Sciences
Binding Sites
Medicine & Life Sciences
Acetylcholine
Medicine & Life Sciences
Cysteine Loop Ligand-Gated Ion Channel Receptors
Medicine & Life Sciences
Ligands
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 1985 2020
Mechanism of calcium potentiation of alpha7 nicotinic receptors
7/1/16 → 6/30/20
Project: Research project › Research Project
Nicotinic Receptors
Calcium
Divalent Cations
Cognition Disorders
Drug Design
Allosteric Coupling in Homomeric Cys-loop Receptors
7/15/06 → 6/30/11
Project: Research project › Research Project
Cysteine Loop Ligand-Gated Ion Channel Receptors
Neurotransmitter Receptor
Binding Sites
Pharmaceutical Preparations
Anti-Anxiety Agents
STRUCTURE AND BIOPHYSICS OF THE ACETYLCHOLINE RECEPTOR
9/1/92 → 4/30/18
Project: Research project › Method to Extend Research in Time (MERIT) Award, Research Project
Cholinergic Receptors
Neurotransmitter Receptor
Congenital Myasthenic Syndromes
Neurotransmitter Agents
Ion Channels
CHEMICAL RECEPTOR EXPRESSION
Sine, S. M. & Dionne, V.
9/29/87 → 8/31/03
Project: Research project › Small Research Grants
Cholinergic Receptors
Ion Channels
Neurotransmitter Agents
Receptors, Serotonin, 5-HT3
Nicotinic Receptors
NATIONAL BIOMEDICAL NMR RESOURCE AT MADISON
Prendergast, F. G., Sine, S. M., Nmrfam, [. V., Gellman, S. H., Handelsman, J. O., Gesteland, R. A. Y., [No Value], H. H., Nealey, P. F., Palmer, A. G., De Pablo, J. J., Tang, P. E. I., Berg, J., Escalante, J., Vickery, L., Zhou, M., Malecki, M., Fry, C., Dejesus, O., Pflueger, F., Parkin, K., Varian, V., Gracz, H., Kleps, R., Berg, J., Escalante, J., Zhou, M., Malecki, M., Parkin, K., Varian, V., Gracz, H., Kleps, R., Vickery, L., Downs, D. M., Pflueger, F., Fillingame, R., Fry, C., Klein, B., Laurence, J., Perczel, A., Griffith, B., Blackwell, H. E., Rankin, S., Gellman, S. H., Frey, P. D., Sigel, R., Jeffries, T. W., van Doren, S., Mujeeb, A., Wand, J., Varani, G., Murphy, W., Walters, K., Oswald, R., Matthews, B. A., Skrynnikov, N., Matsuo, H., Anderson, M., Vierstra, R., Andes, A., Huang, R. C., Ahlquist, P. G., Lan, Q. U. E., Kent, S. B. H., Smith, J. L., Gourse, R. L., Walters, K. J., Komives, E. A., Ntambi, J. A., Murphy, J. R., Lindroth, A. N. N., Rouho, A., Johnson, D. G., [No Value], B. G., Vugmeyster, L., Roucho, A., Schram, V., Halkides, C., Nicholson, L., Angeletti, R., Bolton, P., McKay, D., James, T., Schroeder, C., Erlichman, J., Tsai, M., Nair, H. K., Charles, S., Roberts, J., Shi-Jiang, L., Almo, S., Tsang, P., Feigon, J., Klein, S., Arus, C., Clancy, P., Young, R., Cheng, T., Ulrich, E., Girvin, M. E., Kiessling, L., Satterlee, J., Chobanian, M., Harsy, S., Honggao, Y., Russu, I., Agris, P., Fillingame, R., Gunasekaran, S., Weber, D. J., Wand, A., Record, M. T., Wemmer, D., Bleam, W., Stone, M., Swaminathan, S., Donohue, T., Westler, W., Nmrfam Staff, [. V., Raines, R., Dzakula, Z., Mooberry, E., Anderson, L., Triplett, E., Gilboe, D., Ralph, J., Elfarra, A., Liao, X., Lightfoot, E., Cleland, W. W., Lemaster, D., De Luca, H., Schleucher, J., Downs, D. M., Chien, H., van Doren, S., Frey, P. A., Volkman, B., [No Value], B. G., Paaren, H., Anderson, M., Reddy, V., Deluca, P., Dejesus, O. T., Tran, C., Reed, G., Ruoho, A. E., [No Value], J. H., Bax, A. D., Markley, J., Escalante, J., Mosher, D. F., Butcher, S., Loria, J., Roucho, A., Mosher, D. F., Thorson, J. S., Vugmeyster, L., [No Value], B. G., Cavagnero, S., Sem, D., Halkides, C., McKay, D., Cheng, T., Gunasekaran, S., Ralph, J., De Luca, H., Anderson, M., Schram, V., Nicholson, L., Angeletti, R., Schroeder, C., Erlichman, J., Tsai, M., Nair, H. K., Charles, S., Roberts, J., Shi-Jiang, L., Almo, S., Tsang, P., Feigon, J., Klein, S., Arus, C., Clancy, P., Girvin, M. E., Kiessling, L., Chobanian, M., Harsy, S., Honggao, Y., Russu, I., Agris, P., Fillingame, R., Weber, D. J., Wand, A., Record, M. T., Wemmer, D., Bleam, W., Stone, M., Swaminathan, S., Donohue, T., Nmrfam Staff, [. V., Dzakula, Z., Mooberry, E., Anderson, L., Liao, X., Lightfoot, E., Cleland, W. W., Lemaster, D., Schleucher, J., Downs, D. M., Chien, H., van Doren, S., Frey, P. A., Volkman, B., [No Value], B. G., Paaren, H., Reddy, V., Dejesus, O. T., Tran, C., Reed, G., Ruoho, A. E., [No Value], J. H., Bax, A. D., Zuiderweg, E., Dratz, E., Nair, H., Agard, D., Puglisi, R., Nmrfam, [. V., Dakula, D., Young, R., Bashir, M., Nikolau, B., Miziorko, H., Pardi, A., Abildgaard, F., Stockman, B., Kasper, C., Metzler, D., Serpersu, E., Dumesic, J., Anthonsen, H., Baldwin, R., Filligname, R., Morrissey, M., Gellman, S. H., Guiles, R., Weiss, M. A., Hutchinson, C., Royer, C., Fitzpatrick, P., Menon, A., Neuhaus, F., Steele, J., Goldman, I., Handelsman, J. O., Burnette, R., Redwine, D., Stone, C., Gesteland, R. A. Y., Escalante, J., Northrop, D., Schroeder, C., Banfield, J., Fesik, S., Gauthier, J., Rule, G., Helmke, P., Bushweller, J. H., Walker, J., [No Value], H. H., Dratz, E., Feigon, J., Sundquist, W., Dewerd, L., Ganther, H., Mosher, D. F., Kenealy, W., McGee, W., Harsy, S., Sussman, M., Gmeiner, W., Nealey, P. F., Hemmi, H., Honggao, Y., Palmer, A. G., Dzakula, R., Bashir, M., Agris, P., Reed, J., De Pablo, J. J., Bullerjahn, G., Pariza, M., Fillingame, R., Chambliss, G., Hinck, A., Margolis, F., Johnson, M., Driscoll, J., Qureshi, N., Pyle, A. M., Tang, P. E. I., Burgess, R., Phillips, G. N., Berg, J., Malecki, M., Escalante, J., Vickery, L., Zhou, M., Sidhu, A., Butcher, S., Fry, C., Cavagnero, S., Khorasanizadeh, S., Stauffacher, C. V., Pflueger, F., Fillingame, R., Alexandrescu, A., Sem, D., Parkin, K., Varian, V., Gracz, H., Lutsenko, S., Kleps, R., Phillips, G. N., Berg, J., Malecki, M., Escalante, J., Liao, X., Zhou, M., Sidhu, A., Khorasanizadeh, S., Stauffacher, C. V., Alexandrescu, A., Reed, G., Parkin, K., Varian, V., Gracz, H., Lutsenko, S., Kleps, R., Vickery, L., Garfinkel, M., Downs, D. M., [No Value], B. G., Pflueger, F., Fillingame, R., Sem, D., Fry, C., De Luca, H., Cavagnero, S., Ralph, J., Cleland, W. W., Butcher, S., Zuiderweg, E., Loria, J., Santalucia, J., Klein, B., Laurence, J., Perczel, A., Griffith, B., Blackwell, H. E., Rankin, S., Gellman, S. H., Hellekant, G., van Doren, S., Frey, P. D., Gizachew, D., Sigel, R., Kwang, H., Jeffries, T. W., Mujeeb, A., Wand, J., Varani, G., Bushweller, J. H., Roucho, A., Murphy, W., Walters, K., Mosher, D. F., Oswald, R., Thorson, J. S., Matthews, B. A., Skrynnikov, N., Matsuo, H., Kalodimos, C., Anderson, M., Kiessling, L., B Craig, L., Veglia, G., Assadi-Porter, F., Vierstra, R., Andes, A., Rajagopal, P., Huang, R. C., Dunham, S., Walters, K., Vugmeyster, L., Parson, W., Ahlquist, P. G., Keck, J., Sorgen, P., Craig, E., Weibel, D. B., Lan, Q. U. E., Ensign, J., Escalante, J., Frihart, C., Dmitriev, O., Mari, F., Rivera, E., Kent, S. B. H., van Doren, S., Denu, J., Smith, J. L., Gourse, R. L., Roucho, A., Loria, J., Cook, M., Walters, K. J., Deluca, H., Xie, J., Ansari, A., Mosher, D. F., Andes, D., Dixon, J., [No Value], B. G., Michael, C., Zimei, B., Attie, A., Marino, J. P., Wildman, K. A. H., Whittaker, J., Komives, E. A., Klein, B. S., Schroeder, F., Fry, C., Keutsch, F., Ntambi, J. A., Abraham, B., Yawen, B., Murphy, J. R., Ralph, J., Degrado, W., Lindroth, A. N. N., Wadsworth, K., Thorson, J. S., Hamann, M., Cavagnero, S., Bugni, T., Vugmeyster, L., Rouho, A., Wang, S., Sem, D., Johnson, D. G., Rayment, I., Raines, R., Westler, W., Nmrfam Staff, Nmrfam & Klein, B.
7/1/85 → 2/28/15
Project: Research project › Biotechnology Resource Grants
Spectrometers
Biochemistry
Magnetic resonance
Macromolecules
Nuclear magnetic resonance
Research Output 1974 2019
Potentiation of a neuronal nicotinic receptor via pseudo-agonist site
Mazzaferro, S., Bermudez, I. & Sine, S. M., Jan 1 2019, (Accepted/In press) In : Cellular and Molecular Life Sciences.Research output: Contribution to journal › Article
Nicotinic Receptors
Mutation
Pharmaceutical Preparations
Pharmacology
Drug Design
Full and partial agonists evoke distinct structural changes in opening the muscle acetylcholine receptor channel
Mukhtasimova, N. & Sine, S. M., May 1 2018, In : Journal of General Physiology. 150, 5, p. 713-729 17 p.Research output: Contribution to journal › Article
Cholinergic Receptors
Cysteine
Muscles
Cholinergic Agonists
Choline
11
Citations
Nicotinic acetylcholine receptors at the single-channel level
Bouzat, C. & Sine, S. M., 2017, (Accepted/In press) In : British Journal of Pharmacology.Research output: Contribution to journal › Article
Nicotinic Receptors
Cholinergic Receptors
Patch-Clamp Techniques
Nobel Prize
Ligand-Gated Ion Channels
15
Citations
α 4β2Nicotinic Acetylcholine Receptors; relationships between subunit stoichiometry and function at the single channel level
Mazzaferro, S., Bermudez, I., Sine, S. M. & Stephenson, F. A., Feb 17 2017, In : Journal of Biological Chemistry. 292, 7, p. 2729-2740 12 p.Research output: Contribution to journal › Article
Cholinergic Receptors
Stoichiometry
Nociception
Nicotinic Receptors
Nervous System Diseases
13
Citations
Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR
Mukhtasimova, N., daCosta, C. J. B. & Sine, S. M., 2016, In : Journal of General Physiology. 148, 1, p. 43-63 21 p.Research output: Contribution to journal › Article
Cholinergic Receptors
Muscles
Noise
Cysteine Loop Ligand-Gated Ion Channel Receptors
Vertebrates