• 9693 Citations
  • 60 Scopus h-Index
1974 …2020
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  • 2 Similar Profiles
Cholinergic Receptors Medicine & Life Sciences
Nicotinic Receptors Medicine & Life Sciences
Congenital Myasthenic Syndromes Medicine & Life Sciences
Mutation Medicine & Life Sciences
Binding Sites Medicine & Life Sciences
Acetylcholine Medicine & Life Sciences
Ligands Medicine & Life Sciences
Cysteine Loop Ligand-Gated Ion Channel Receptors Medicine & Life Sciences

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Projects 1985 2020

Nicotinic Receptors
Calcium
Divalent Cations
Cognition Disorders
Drug Design
Cysteine Loop Ligand-Gated Ion Channel Receptors
Neurotransmitter Receptor
Binding Sites
Pharmaceutical Preparations
Anti-Anxiety Agents
Cholinergic Receptors
Neurotransmitter Receptor
Congenital Myasthenic Syndromes
Neurotransmitter Agents
Ion Channels

CHEMICAL RECEPTOR EXPRESSION

Sine, S. M. & Dionne, V.

National Institutes of Health

9/29/878/31/03

Project: Research project

Cholinergic Receptors
Ion Channels
Neurotransmitter Agents
Receptors, Serotonin, 5-HT3
Nicotinic Receptors

NATIONAL BIOMEDICAL NMR RESOURCE AT MADISON

Prendergast, F. G., Sine, S. M., Nmrfam, [. V., Gellman, S. H., Handelsman, J. O., Gesteland, R. A. Y., [No Value], H. H., Nealey, P. F., Palmer, A. G., De Pablo, J. J., Tang, P. E. I., Berg, J., Escalante, J., Vickery, L., Zhou, M., Malecki, M., Fry, C., Dejesus, O., Pflueger, F., Parkin, K., Varian, V., Gracz, H., Kleps, R., Berg, J., Escalante, J., Zhou, M., Malecki, M., Parkin, K., Varian, V., Gracz, H., Kleps, R., Vickery, L., Downs, D. M., Pflueger, F., Fillingame, R., Fry, C., Klein, B., Laurence, J., Perczel, A., Griffith, B., Blackwell, H. E., Rankin, S., Gellman, S. H., Frey, P. D., Sigel, R., Jeffries, T. W., van Doren, S., Mujeeb, A., Wand, J., Varani, G., Murphy, W., Walters, K., Oswald, R., Matthews, B. A., Skrynnikov, N., Matsuo, H., Anderson, M., Vierstra, R., Andes, A., Huang, R. C., Ahlquist, P. G., Lan, Q. U. E., Kent, S. B. H., Smith, J. L., Gourse, R. L., Walters, K. J., Komives, E. A., Ntambi, J. A., Murphy, J. R., Lindroth, A. N. N., Rouho, A., Johnson, D. G., [No Value], B. G., Vugmeyster, L., Roucho, A., Schram, V., Halkides, C., Nicholson, L., Angeletti, R., Bolton, P., McKay, D., James, T., Schroeder, C., Erlichman, J., Tsai, M., Nair, H. K., Charles, S., Roberts, J., Shi-Jiang, L., Almo, S., Tsang, P., Feigon, J., Klein, S., Arus, C., Clancy, P., Young, R., Cheng, T., Ulrich, E., Girvin, M. E., Kiessling, L., Satterlee, J., Chobanian, M., Harsy, S., Honggao, Y., Russu, I., Agris, P., Fillingame, R., Gunasekaran, S., Weber, D. J., Wand, A., Record, M. T., Wemmer, D., Bleam, W., Stone, M., Swaminathan, S., Donohue, T., Westler, W., Nmrfam Staff, [. V., Raines, R., Dzakula, Z., Mooberry, E., Anderson, L., Triplett, E., Gilboe, D., Ralph, J., Elfarra, A., Liao, X., Lightfoot, E., Cleland, W. W., Lemaster, D., De Luca, H., Schleucher, J., Downs, D. M., Chien, H., van Doren, S., Frey, P. A., Volkman, B., [No Value], B. G., Paaren, H., Anderson, M., Reddy, V., Deluca, P., Dejesus, O. T., Tran, C., Reed, G., Ruoho, A. E., [No Value], J. H., Bax, A. D., Markley, J., Escalante, J., Mosher, D. F., Butcher, S., Loria, J., Roucho, A., Mosher, D. F., Thorson, J. S., Vugmeyster, L., [No Value], B. G., Cavagnero, S., Sem, D., Halkides, C., McKay, D., Cheng, T., Gunasekaran, S., Ralph, J., De Luca, H., Anderson, M., Schram, V., Nicholson, L., Angeletti, R., Schroeder, C., Erlichman, J., Tsai, M., Nair, H. K., Charles, S., Roberts, J., Shi-Jiang, L., Almo, S., Tsang, P., Feigon, J., Klein, S., Arus, C., Clancy, P., Girvin, M. E., Kiessling, L., Chobanian, M., Harsy, S., Honggao, Y., Russu, I., Agris, P., Fillingame, R., Weber, D. J., Wand, A., Record, M. T., Wemmer, D., Bleam, W., Stone, M., Swaminathan, S., Donohue, T., Nmrfam Staff, [. V., Dzakula, Z., Mooberry, E., Anderson, L., Liao, X., Lightfoot, E., Cleland, W. W., Lemaster, D., Schleucher, J., Downs, D. M., Chien, H., van Doren, S., Frey, P. A., Volkman, B., [No Value], B. G., Paaren, H., Reddy, V., Dejesus, O. T., Tran, C., Reed, G., Ruoho, A. E., [No Value], J. H., Bax, A. D., Zuiderweg, E., Dratz, E., Nair, H., Agard, D., Puglisi, R., Nmrfam, [. V., Dakula, D., Young, R., Bashir, M., Nikolau, B., Miziorko, H., Pardi, A., Abildgaard, F., Stockman, B., Kasper, C., Metzler, D., Serpersu, E., Dumesic, J., Anthonsen, H., Baldwin, R., Filligname, R., Morrissey, M., Gellman, S. H., Guiles, R., Weiss, M. A., Hutchinson, C., Royer, C., Fitzpatrick, P., Menon, A., Neuhaus, F., Steele, J., Goldman, I., Handelsman, J. O., Burnette, R., Redwine, D., Stone, C., Gesteland, R. A. Y., Escalante, J., Northrop, D., Schroeder, C., Banfield, J., Fesik, S., Gauthier, J., Rule, G., Helmke, P., Bushweller, J. H., Walker, J., [No Value], H. H., Dratz, E., Feigon, J., Sundquist, W., Dewerd, L., Ganther, H., Mosher, D. F., Kenealy, W., McGee, W., Harsy, S., Sussman, M., Gmeiner, W., Nealey, P. F., Hemmi, H., Honggao, Y., Palmer, A. G., Dzakula, R., Bashir, M., Agris, P., Reed, J., De Pablo, J. J., Bullerjahn, G., Pariza, M., Fillingame, R., Chambliss, G., Hinck, A., Margolis, F., Johnson, M., Driscoll, J., Qureshi, N., Pyle, A. M., Tang, P. E. I., Burgess, R., Phillips, G. N., Berg, J., Malecki, M., Escalante, J., Vickery, L., Zhou, M., Sidhu, A., Butcher, S., Fry, C., Cavagnero, S., Khorasanizadeh, S., Stauffacher, C. V., Pflueger, F., Fillingame, R., Alexandrescu, A., Sem, D., Parkin, K., Varian, V., Gracz, H., Lutsenko, S., Kleps, R., Phillips, G. N., Berg, J., Malecki, M., Escalante, J., Liao, X., Zhou, M., Sidhu, A., Khorasanizadeh, S., Stauffacher, C. V., Alexandrescu, A., Reed, G., Parkin, K., Varian, V., Gracz, H., Lutsenko, S., Kleps, R., Vickery, L., Garfinkel, M., Downs, D. M., [No Value], B. G., Pflueger, F., Fillingame, R., Sem, D., Fry, C., De Luca, H., Cavagnero, S., Ralph, J., Cleland, W. W., Butcher, S., Zuiderweg, E., Loria, J., Santalucia, J., Klein, B., Laurence, J., Perczel, A., Griffith, B., Blackwell, H. E., Rankin, S., Gellman, S. H., Hellekant, G., van Doren, S., Frey, P. D., Gizachew, D., Sigel, R., Kwang, H., Jeffries, T. W., Mujeeb, A., Wand, J., Varani, G., Bushweller, J. H., Roucho, A., Murphy, W., Walters, K., Mosher, D. F., Oswald, R., Thorson, J. S., Matthews, B. A., Skrynnikov, N., Matsuo, H., Kalodimos, C., Anderson, M., Kiessling, L., B Craig, L., Veglia, G., Assadi-Porter, F., Vierstra, R., Andes, A., Rajagopal, P., Huang, R. C., Dunham, S., Walters, K., Vugmeyster, L., Parson, W., Ahlquist, P. G., Keck, J., Sorgen, P., Craig, E., Weibel, D. B., Lan, Q. U. E., Ensign, J., Escalante, J., Frihart, C., Dmitriev, O., Mari, F., Rivera, E., Kent, S. B. H., van Doren, S., Denu, J., Smith, J. L., Gourse, R. L., Roucho, A., Loria, J., Cook, M., Walters, K. J., Deluca, H., Xie, J., Ansari, A., Mosher, D. F., Andes, D., Dixon, J., [No Value], B. G., Michael, C., Zimei, B., Attie, A., Marino, J. P., Wildman, K. A. H., Whittaker, J., Komives, E. A., Klein, B. S., Schroeder, F., Fry, C., Keutsch, F., Ntambi, J. A., Abraham, B., Yawen, B., Murphy, J. R., Ralph, J., Degrado, W., Lindroth, A. N. N., Wadsworth, K., Thorson, J. S., Hamann, M., Cavagnero, S., Bugni, T., Vugmeyster, L., Rouho, A., Wang, S., Sem, D., Johnson, D. G., Rayment, I., Raines, R., Westler, W., Nmrfam Staff, Nmrfam & Klein, B.

National Institutes of Health

7/1/852/28/15

Project: Research project

Spectrometers
Biochemistry
Magnetic resonance
Macromolecules
Nuclear magnetic resonance

Research Output 1974 2019

  • 9693 Citations
  • 60 Scopus h-Index
  • 149 Article
  • 2 Conference contribution
  • 1 Comment/debate
1 Citation (Scopus)

Potentiation of a neuronal nicotinic receptor via pseudo-agonist site

Mazzaferro, S., Bermudez, I. & Sine, S. M., Jan 1 2019, (Accepted/In press) In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticle

Nicotinic Receptors
Mutation
Pharmaceutical Preparations
Pharmacology
Drug Design

Structural basis for α-bungarotoxin insensitivity of neuronal nicotinic acetylcholine receptors

Sine, S. M., Strikwerda, J. R. & Mazzaferro, S., Jan 1 2019, In : Neuropharmacology. 107660.

Research output: Contribution to journalArticle

Bungarotoxins
Nicotinic Receptors
Muscles
neuronal bungarotoxin
Sequence Alignment
1 Citation (Scopus)

Full and partial agonists evoke distinct structural changes in opening the muscle acetylcholine receptor channel

Mukhtasimova, N. & Sine, S. M., May 1 2018, In : Journal of General Physiology. 150, 5, p. 713-729 17 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Cysteine
Muscles
Cholinergic Agonists
Choline
1 Citation (Scopus)

Mutations causing congenital myasthenia reveal principal coupling pathway in the acetylcholine receptor ε-subunit

Shen, X. M., Brengman, J. M., Shen, S., Durmus, H., Preethish-Kumar, V., Yuceyar, N., Vengalil, S., Nalini, A., Deymeer, F., Sine, S. M. & Engel, A. G., Jan 25 2018, In : JCI insight. 3, 2

Research output: Contribution to journalArticle

Open Access
Congenital Myasthenic Syndromes
Cholinergic Receptors
Mutation
Cysteine Loop Ligand-Gated Ion Channel Receptors
Muscles
14 Citations (Scopus)

Nicotinic acetylcholine receptors at the single-channel level

Bouzat, C. & Sine, S. M., 2017, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Nicotinic Receptors
Cholinergic Receptors
Patch-Clamp Techniques
Nobel Prize
Ligand-Gated Ion Channels