• 9758 Citations
  • 61 Scopus h-Index
1974 …2020
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Research Output 1974 2019

  • 9758 Citations
  • 61 Scopus h-Index
  • 150 Article
  • 2 Conference contribution
  • 1 Comment/debate
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Article
2019
1 Citation (Scopus)

Potentiation of a neuronal nicotinic receptor via pseudo-agonist site

Mazzaferro, S., Bermudez, I. & Sine, S. M., Jan 1 2019, (Accepted/In press) In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticle

Nicotinic Receptors
Mutation
Pharmaceutical Preparations
Pharmacology
Drug Design

Structural basis for α-bungarotoxin insensitivity of neuronal nicotinic acetylcholine receptors

Sine, S. M., Strikwerda, J. R. & Mazzaferro, S., Jan 1 2019, In : Neuropharmacology. 107660.

Research output: Contribution to journalArticle

Bungarotoxins
Nicotinic Receptors
Muscles
neuronal bungarotoxin
Sequence Alignment
2018

Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors

Noori, H. R., Mücksch, C., Vengeliene, V., Schönig, K., Takahashi, T. T., Mukhtasimova, N., Bagher Oskouei, M., Mosqueira, M., Bartsch, D., Fink, R., Urbassek, H. M., Spanagel, R. & Sine, S. M., Dec 1 2018, In : Communications Biology. 1, 1, 159.

Research output: Contribution to journalArticle

Open Access
muscle fatigue
Muscle Fatigue
Nicotinic Receptors
Muscle
Ethanol
1 Citation (Scopus)

Full and partial agonists evoke distinct structural changes in opening the muscle acetylcholine receptor channel

Mukhtasimova, N. & Sine, S. M., May 1 2018, In : Journal of General Physiology. 150, 5, p. 713-729 17 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Cysteine
Muscles
Cholinergic Agonists
Choline
1 Citation (Scopus)

Mutations causing congenital myasthenia reveal principal coupling pathway in the acetylcholine receptor ε-subunit

Shen, X. M., Brengman, J. M., Shen, S., Durmus, H., Preethish-Kumar, V., Yuceyar, N., Vengalil, S., Nalini, A., Deymeer, F., Sine, S. M. & Engel, A. G., Jan 25 2018, In : JCI insight. 3, 2

Research output: Contribution to journalArticle

Open Access
Congenital Myasthenic Syndromes
Cholinergic Receptors
Mutation
Cysteine Loop Ligand-Gated Ion Channel Receptors
Muscles
2017
14 Citations (Scopus)

Nicotinic acetylcholine receptors at the single-channel level

Bouzat, C. & Sine, S. M., 2017, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Nicotinic Receptors
Cholinergic Receptors
Patch-Clamp Techniques
Nobel Prize
Ligand-Gated Ion Channels
19 Citations (Scopus)

α 4β2Nicotinic Acetylcholine Receptors; relationships between subunit stoichiometry and function at the single channel level

Mazzaferro, S., Bermudez, I., Sine, S. M. & Stephenson, F. A., Feb 17 2017, In : Journal of Biological Chemistry. 292, 7, p. 2729-2740 12 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Stoichiometry
Nociception
Nicotinic Receptors
Nervous System Diseases
2016
17 Citations (Scopus)

Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR

Mukhtasimova, N., daCosta, C. J. B. & Sine, S. M., 2016, In : Journal of General Physiology. 148, 1, p. 43-63 21 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Muscles
Noise
Cysteine Loop Ligand-Gated Ion Channel Receptors
Vertebrates
4 Citations (Scopus)

Investigation of congenital myasthenia reveals functional asymmetry of invariant acetylcholine receptor (AChR) cys-loop aspartates

Shen, X. M., Brengman, J., Neubauer, D., Sine, S. M. & Engel, A. G., Feb 12 2016, In : Journal of Biological Chemistry. 291, 7, p. 3291-3301 11 p.

Research output: Contribution to journalArticle

Congenital Myasthenic Syndromes
Cholinergic Receptors
Aspartic Acid
Cysteine Loop Ligand-Gated Ion Channel Receptors
Mutation
2015
157 Citations (Scopus)

Congenital myasthenic syndromes: Pathogenesis, diagnosis, and treatment

Engel, A. G., Shen, X. M., Selcen, D. & Sine, S. M., Apr 1 2015, In : The Lancet Neurology. 14, 4, p. 420-434 15 p.

Research output: Contribution to journalArticle

Congenital Myasthenic Syndromes
Therapeutics
Motor Endplate
Exome
Cholinergic Agonists
18 Citations (Scopus)

Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors

Dacosta, C. J. B., Free, C. R. & Sine, S. M., Aug 18 2015, In : Nature Communications. 6, 8057.

Research output: Contribution to journalArticle

acetylcholine
Bungarotoxins
Cholinergic Receptors
Stoichiometry
stoichiometry
2013
37 Citations (Scopus)

Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera

Huang, S., Li, S. X., Bren, N., Cheng, K., Gomoto, R., Chen, L. & Sine, S. M., Sep 1 2013, In : Biochemical Journal. 454, 2, p. 303-310 8 p.

Research output: Contribution to journalArticle

Bungarotoxins
epibatidine
Neurotoxins
Nicotinic Receptors
Ligands
12 Citations (Scopus)

Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors

Sine, S. M., Huang, S., Li, S. X., Dacosta, C. J. B. & Chen, L., Sep 1 2013, In : Biochemical Journal. 454, 2, p. 311-321 11 p.

Research output: Contribution to journalArticle

Bungarotoxins
Nicotinic Receptors
Ligands
Mutation
Acetylcholine
16 Citations (Scopus)

Nicotinic receptor transduction zone: Invariant arginine couples to multiple electron-rich residues

Mukhtasimova, N. & Sine, S. M., Jan 22 2013, In : Biophysical Journal. 104, 2, p. 355-367 13 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Arginine
Communication
Electrons
Ligands
37 Citations (Scopus)

Stoichiometry for activation of neuronal α7 nicotinic receptors

Andersen, N., Corradi, J., Sine, S. M. & Bouzat, C., Dec 17 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 51, p. 20819-20824 6 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Acetylcholine
Binding Sites
Neuronal Plasticity
Aptitude
17 Citations (Scopus)

Stoichiometry for drug potentiation of a pentameric ion channel

DaCosta, C. J. B. & Sine, S. M., Apr 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6595-6600 6 p.

Research output: Contribution to journalArticle

Drug Synergism
Ion Channels
Pharmaceutical Preparations
Ligand-Gated Ion Channels
Nicotinic Receptors
2012
67 Citations (Scopus)

End-plate acetylcholine receptor: Structure, mechanism, pharmacology, and disease

Sine, S. M., Jul 1 2012, In : Physiological Reviews. 92, 3, p. 1189-1234 46 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Choline
Neurotransmitter Receptor
Pharmacology
Cysteine Loop Ligand-Gated Ion Channel Receptors
21 Citations (Scopus)

Highly fatal fast-channel syndrome caused by AChR ε subunit mutation at the agonist binding site

Shen, X. M., Brengman, J. M., Edvardson, S., Sine, S. M. & Engel, A. G., Jul 31 2012, In : Neurology. 79, 5, p. 449-454 6 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Binding Sites
Pyridostigmine Bromide
Mutation
Cholinergic Agonists
35 Citations (Scopus)

Intramembrane proton binding site linked to activation of bacterial pentameric ion channel

Wang, H. L., Cheng, X. & Sine, S. M., Feb 24 2012, In : Journal of Biological Chemistry. 287, 9, p. 6482-6489 8 p.

Research output: Contribution to journalArticle

Ion Channels
Protons
Hydrogen bonds
Chemical activation
Binding Sites
18 Citations (Scopus)

Myasthenic syndrome AChRα C-loop mutant disrupts initiation of channel gating

Shen, X. M., Brengman, J. M., Sine, S. M. & Engel, A. G., Jul 2 2012, In : Journal of Clinical Investigation. 122, 7, p. 2613-2621 9 p.

Research output: Contribution to journalArticle

Muscle Weakness
Cholinergic Receptors
Mutation
Congenital Myasthenic Syndromes
Cultured Cells
24 Citations (Scopus)

New horizons for congenital myasthenic syndromes

Engel, A. G., Shen, X. M., Selcen, D. & Sine, S. M., Dec 2012, In : Annals of the New York Academy of Sciences. 1275, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

Congenital Myasthenic Syndromes
Plectin
Glycosylation
Defects
Choline O-Acetyltransferase
2011
20 Citations (Scopus)

Functional relationships between agonist binding sites and coupling regions of homomeric Cys-loop receptors

Andersen, N., Corradi, J., Bartos, M., Sine, S. M. & Bouzat, C., Mar 9 2011, In : Journal of Neuroscience. 31, 10, p. 3662-3669 8 p.

Research output: Contribution to journalArticle

Cysteine Loop Ligand-Gated Ion Channel Receptors
Binding Sites
Mutation
Ion Channels
Catalytic Domain
125 Citations (Scopus)

Ligand-binding domain of an α 7-nicotinic receptor chimera and its complex with agonist

Li, S. X., Huang, S., Bren, N., Noridomi, K., Dellisanti, C. D., Sine, S. M. & Chen, L., Oct 2011, In : Nature Neuroscience. 14, 10, p. 1253-1259 7 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Cholinergic Receptors
epibatidine
Ligands
Signal Transduction
45 Citations (Scopus)

Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation

daCosta, C. J. P., Free, C. R., Corradi, J., Bouzat, C. & Sine, S. M., Sep 28 2011, In : Journal of Neuroscience. 31, 39, p. 13870-13879 10 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Mutation
Nicotinic Receptors
Nervous System Diseases
Schizophrenia
2010
1 Citation (Scopus)

Function of the acetylcholine receptor at the atomic scale

Wang, H. L. & Sine, S. M., Dec 2010, In : Journal of Computational and Theoretical Nanoscience. 7, 12, p. 2538-2542 5 p.

Research output: Contribution to journalArticle

acetylcholine
Acetylcholine
Ion Channels
Translocation
Cholinergic Receptors
19 Citations (Scopus)

On the origin of ion selectivity in the Cys-loop receptor family

Sine, S. M., Wang, H. L., Hansen, S. & Taylor, P., Jan 2010, In : Journal of Molecular Neuroscience. 40, 1-2, p. 70-76 7 p.

Research output: Contribution to journalArticle

Cysteine Loop Ligand-Gated Ion Channel Receptors
Cations
Ions
Nicotinic Receptors
Molecular Dynamics Simulation
69 Citations (Scopus)

What have we learned from the congenital myasthenic syndromes

Engel, A. G., Shen, X. M., Selcen, D. & Sine, S. M., Jan 2010, In : Journal of Molecular Neuroscience. 40, 1-2, p. 143-153 11 p.

Research output: Contribution to journalArticle

Congenital Myasthenic Syndromes
Genes
Mutation
Acetylcholinesterase
Neuromuscular Junction
2009
70 Citations (Scopus)

Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to Pre-M1 and M2-M3 regions

Lee, W. Y., Free, C. R. & Sine, S. M., Mar 11 2009, In : Journal of Neuroscience. 29, 10, p. 3189-3199 11 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Cholinergic Receptors
Ion Channels
Thermodynamics
Mutagenesis
142 Citations (Scopus)

Detection and trapping of intermediate states priming nicotinic receptor channel opening

Mukhtasimova, N., Lee, W. Y., Wang, H. L. & Sine, S. M., May 21 2009, In : Nature. 459, 7245, p. 451-454 4 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Cholinergic Receptors
Binding Sites
Cations
Synaptic Transmission
31 Citations (Scopus)

Molecular-dynamics simulations of ELIC - A prokaryotic homologue of the nicotinic acetylcholine receptor

Cheng, X., Ivanov, I., Wang, H., Sine, S. M. & McCammon, J. A., 2009, In : Biophysical Journal. 96, 11, p. 4502-4513 12 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Molecular Dynamics Simulation
Ligand-Gated Ion Channels
Pectobacterium chrysanthemi
Acetylcholine
87 Citations (Scopus)

Number and locations of agonist binding sites required to activate homomeric cys-loop receptors

Rayes, D., De Rosa, M. J., Sine, S. M. & Bouzat, C., May 6 2009, In : Journal of Neuroscience. 29, 18, p. 6022-6032 11 p.

Research output: Contribution to journalArticle

Cysteine Loop Ligand-Gated Ion Channel Receptors
Binding Sites
Mutation
Hominidae
28 Citations (Scopus)

Single-channel current through nicotinic receptor produced by closure of binding site C-loop

Wang, H. L., Toghraee, R., Papke, D., Cheng, X. L., McCammon, J. A., Ravaioli, U. & Sine, S. M., 2009, In : Biophysical Journal. 96, 9, p. 3582-3590 9 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Molecular Dynamics Simulation
Binding Sites
Ions
Structural Models
2008
46 Citations (Scopus)

An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance

Hansen, S. B., Wang, H. L., Taylor, P. & Sine, S. M., Dec 26 2008, In : Journal of Biological Chemistry. 283, 52, p. 36066-36070 5 p.

Research output: Contribution to journalArticle

Cysteine Loop Ligand-Gated Ion Channel Receptors
Ions
Lysine
Anions
Motor Endplate
27 Citations (Scopus)

Congenital myasthenia-related AChR δ subunit mutation interferes with intersubunit communication essential for channel gating

Shen, X. M., Fukuda, T., Ohno, K., Sine, S. M. & Engel, A. G., May 1 2008, In : Journal of Clinical Investigation. 118, 5, p. 1867-1876 10 p.

Research output: Contribution to journalArticle

Congenital Myasthenic Syndromes
Communication
Mutation
Proteins
Neuromuscular Junction
46 Citations (Scopus)

Control of cation permeation through the nicotinic receptor channel

Wang, H. L., Cheng, X., Taylor, P., McCammon, J. A. & Sine, S. M., Feb 2008, In : PLoS Computational Biology. 4, 2

Research output: Contribution to journalArticle

Nicotinic Receptors
Permeation
Receptor
Cations
cations
18 Citations (Scopus)

Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine α3β2 receptors

Wu, T. Y., Smith, C. M., Sine, S. M. & Levandoski, M. M., Aug 2008, In : Molecular Pharmacology. 74, 2, p. 466-475 10 p.

Research output: Contribution to journalArticle

Morantel
Nicotinic Receptors
Acetylcholine
Anthelmintics
Xenopus laevis
38 Citations (Scopus)

Nicotinic receptor interloop proline anchors β1-β2 and Cys loops in coupling agonist binding to channel gating

Lee, W. Y., Free, C. R. & Sine, S. M., Aug 2008, In : Journal of General Physiology. 132, 2, p. 265-278 14 p.

Research output: Contribution to journalArticle

Cysteine Loop Ligand-Gated Ion Channel Receptors
Peripheral Nervous System
Nicotinic Receptors
Site-Directed Mutagenesis
Hydrophobic and Hydrophilic Interactions
82 Citations (Scopus)

The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization

Bouzat, C., Bartos, M., Corradi, J. & Sine, S. M., Jul 30 2008, In : Journal of Neuroscience. 28, 31, p. 7808-7819 12 p.

Research output: Contribution to journalArticle

Cysteine Loop Ligand-Gated Ion Channel Receptors
Synaptic Transmission
2007
34 Citations (Scopus)

An intersubunit trigger of channel gating in the muscle nicotinic receptor

Mukhtasimova, N. & Sine, S. M., Apr 11 2007, In : Journal of Neuroscience. 27, 15, p. 4110-4119 10 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Disulfides
Binding Sites
Muscles
Torpedo
58 Citations (Scopus)

Barriers to ion translocation in cationic and anionic receptors from the cys-loop family

Ivanov, I., Cheng, X., Sine, S. M. & McCammon, J. A., Jul 4 2007, In : Journal of the American Chemical Society. 129, 26, p. 8217-8224 8 p.

Research output: Contribution to journalArticle

Cysteine Loop Ligand-Gated Ion Channel Receptors
Nicotinic Receptors
Ions
Glycine Receptors
Amino acids
57 Citations (Scopus)

Nanosecond-timescale conformational dynamics of the human α7 nicotinic acetylcholine receptor

Cheng, X., Ivanov, I., Wang, H., Sine, S. M. & McCammon, J. A., Oct 2007, In : Biophysical Journal. 93, 8, p. 2622-2634 13 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Molecular Dynamics Simulation
Principal Component Analysis
2006
382 Citations (Scopus)

Recent advances in Cys-loop receptor structure and function

Sine, S. M. & Engel, A. G., Mar 23 2006, In : Nature. 440, 7083, p. 448-455 8 p.

Research output: Contribution to journalArticle

Cysteine Loop Ligand-Gated Ion Channel Receptors
Neurotransmitter Agents
Mutation
Membrane Potentials
Nervous System
37 Citations (Scopus)

Slow-channel mutation in acetylcholine receptor αM4 domain and its efficient knockdown

Shen, X. M., Deymeer, F., Sine, S. M. & Engel, A. G., Jul 2006, In : Annals of Neurology. 60, 1, p. 128-136 9 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Small Interfering RNA
Alleles
Muscle Weakness
Mutation
33 Citations (Scopus)

Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-Loop

Gao, F., Mer, G., Tonelli, M., Hansen, S. B., Burghardt, T. P., Taylor, P. & Sine, S. M., 2006, In : Molecular Pharmacology. 70, 4, p. 1230-1235 6 p.

Research output: Contribution to journalArticle

Acetylcholine
Carrier Proteins
Cysteine
Cysteine Loop Ligand-Gated Ion Channel Receptors
Spectrum Analysis
96 Citations (Scopus)

Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors

Cheng, X., Wang, H., Grant, B., Sine, S. M. & McCammon, J. A., 2006, In : PLoS Computational Biology. 2, 9, p. 1173-1184 12 p.

Research output: Contribution to journalArticle

molecular dynamics
Nicotinic Receptors
Molecular Dynamics Simulation
Molecular Dynamics
Receptor
2005
114 Citations (Scopus)

Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence

Gao, F., Bren, N., Burghardt, T. P., Hansen, S., Henchman, R. H., Taylor, P., McCammon, J. A. & Sine, S. M., Mar 4 2005, In : Journal of Biological Chemistry. 280, 9, p. 8443-8451 9 p.

Research output: Contribution to journalArticle

Tryptophan
Acetylcholine
Carrier Proteins
Fluorescence
Molecular Dynamics Simulation
133 Citations (Scopus)

Current understanding of congenital myasthenic syndromes

Engel, A. G. & Sine, S. M., Jun 2005, In : Current Opinion in Pharmacology. 5, 3 SPEC. ISS., p. 308-321 14 p.

Research output: Contribution to journalArticle

Congenital Myasthenic Syndromes
Choline O-Acetyltransferase
Cholinergic Receptors
Motor Endplate
Crystallography
89 Citations (Scopus)

Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor

Mukhtasimova, N., Free, C. & Sine, S. M., Jul 2005, In : Journal of General Physiology. 126, 1, p. 23-39 17 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Static Electricity
Muscles
Mutation
Binding Sites
58 Citations (Scopus)

Ligand-induced conformational change in the α7 nicotinic receptor ligand binding domain

Henchman, R. H., Wang, H. L., Sine, S. M., Taylor, P. & McCammon, J. A., Apr 2005, In : Biophysical Journal. 88, 4, p. 2564-2576 13 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Tubocurarine
Ligands
Acetylcholine
Cholinergic Agonists
221 Citations (Scopus)

Principal pathway coupling agonist binding to channel gating in nicotinic receptors

Lee, W. Y. & Sine, S. M., Nov 10 2005, In : Nature. 438, 7065, p. 243-247 5 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Neurotransmitter Agents
arginine glutamate
Torpedo
Neurotransmitter Receptor