• 9919 Citations
  • 61 Scopus h-Index
1974 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2019

Potentiation of a neuronal nicotinic receptor via pseudo-agonist site

Mazzaferro, S., Bermudez, I. & Sine, S. M., Mar 30 2019, In : Cellular and Molecular Life Sciences. 76, 6, p. 1151-1167 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Slow-channel myasthenia due to novel mutation in M2 domain of AChR delta subunit

Shen, X. M., Milone, M., Wang, H. L., Banwell, B., Selcen, D., Sine, S. M. & Engel, A. G., Oct 1 2019, In : Annals of Clinical and Translational Neurology. 6, 10, p. 2066-2078 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Structural basis for α-bungarotoxin insensitivity of neuronal nicotinic acetylcholine receptors

Sine, S. M., Strikwerda, J. R. & Mazzaferro, S., Jan 1 2019, In : Neuropharmacology. 107660.

Research output: Contribution to journalArticle

2018

Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors

Noori, H. R., Mücksch, C., Vengeliene, V., Schönig, K., Takahashi, T. T., Mukhtasimova, N., Bagher Oskouei, M., Mosqueira, M., Bartsch, D., Fink, R., Urbassek, H. M., Spanagel, R. & Sine, S. M., Dec 1 2018, In : Communications Biology. 1, 1, 159.

Research output: Contribution to journalArticle

Open Access

Full and partial agonists evoke distinct structural changes in opening the muscle acetylcholine receptor channel

Mukhtasimova, N. & Sine, S. M., May 1 2018, In : Journal of General Physiology. 150, 5, p. 713-729 17 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mutations causing congenital myasthenia reveal principal coupling pathway in the acetylcholine receptor ε-subunit

Shen, X. M., Brengman, J. M., Shen, S., Durmus, H., Preethish-Kumar, V., Yuceyar, N., Vengalil, S., Nalini, A., Deymeer, F., Sine, S. M. & Engel, A. G., Jan 25 2018, In : JCI insight. 3, 2

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2017

Nicotinic acetylcholine receptors at the single-channel level

Bouzat, C. & Sine, S. M., 2017, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

17 Scopus citations

α 4β2Nicotinic Acetylcholine Receptors; relationships between subunit stoichiometry and function at the single channel level

Mazzaferro, S., Bermudez, I., Sine, S. M. & Stephenson, F. A., Feb 17 2017, In : Journal of Biological Chemistry. 292, 7, p. 2729-2740 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2016

Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR

Mukhtasimova, N., daCosta, C. J. B. & Sine, S. M., Jan 1 2016, In : Journal of General Physiology. 148, 1, p. 43-63 21 p.

Research output: Contribution to journalArticle

20 Scopus citations

Investigation of congenital myasthenia reveals functional asymmetry of invariant acetylcholine receptor (AChR) cys-loop aspartates

Shen, X. M., Brengman, J., Neubauer, D., Sine, S. M. & Engel, A. G., Feb 12 2016, In : Journal of Biological Chemistry. 291, 7, p. 3291-3301 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Congenital myasthenic syndromes: Pathogenesis, diagnosis, and treatment

Engel, A. G., Shen, X. M., Selcen, D. & Sine, S. M., Apr 1 2015, In : The Lancet Neurology. 14, 4, p. 420-434 15 p.

Research output: Contribution to journalArticle

187 Scopus citations

Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors

Dacosta, C. J. B., Free, C. R. & Sine, S. M., Aug 18 2015, In : Nature Communications. 6, 8057.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera

Huang, S., Li, S. X., Bren, N., Cheng, K., Gomoto, R., Chen, L. & Sine, S. M., Sep 1 2013, In : Biochemical Journal. 454, 2, p. 303-310 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors

Sine, S. M., Huang, S., Li, S. X., Dacosta, C. J. B. & Chen, L., Sep 1 2013, In : Biochemical Journal. 454, 2, p. 311-321 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Nicotinic receptor transduction zone: Invariant arginine couples to multiple electron-rich residues

Mukhtasimova, N. & Sine, S. M., Jan 22 2013, In : Biophysical Journal. 104, 2, p. 355-367 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Stoichiometry for activation of neuronal α7 nicotinic receptors

Andersen, N., Corradi, J., Sine, S. M. & Bouzat, C., Dec 17 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 51, p. 20819-20824 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Stoichiometry for drug potentiation of a pentameric ion channel

DaCosta, C. J. B. & Sine, S. M., Apr 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6595-6600 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2012

End-plate acetylcholine receptor: Structure, mechanism, pharmacology, and disease

Sine, S. M., Jul 1 2012, In : Physiological Reviews. 92, 3, p. 1189-1234 46 p.

Research output: Contribution to journalArticle

75 Scopus citations

Highly fatal fast-channel syndrome caused by AChR ε subunit mutation at the agonist binding site

Shen, X. M., Brengman, J. M., Edvardson, S., Sine, S. M. & Engel, A. G., Jul 31 2012, In : Neurology. 79, 5, p. 449-454 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Intramembrane proton binding site linked to activation of bacterial pentameric ion channel

Wang, H. L., Cheng, X. & Sine, S. M., Feb 24 2012, In : Journal of Biological Chemistry. 287, 9, p. 6482-6489 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Myasthenic syndrome AChRα C-loop mutant disrupts initiation of channel gating

Shen, X. M., Brengman, J. M., Sine, S. M. & Engel, A. G., Jul 2 2012, In : Journal of Clinical Investigation. 122, 7, p. 2613-2621 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

New horizons for congenital myasthenic syndromes

Engel, A. G., Shen, X. M., Selcen, D. & Sine, S., Dec 2012, In : Annals of the New York Academy of Sciences. 1275, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
2011

Functional relationships between agonist binding sites and coupling regions of homomeric Cys-loop receptors

Andersen, N., Corradi, J., Bartos, M., Sine, S. M. & Bouzat, C., Mar 9 2011, In : Journal of Neuroscience. 31, 10, p. 3662-3669 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

Li, S. X., Huang, S., Bren, N., Noridomi, K., Dellisanti, C. D., Sine, S. M. & Chen, L., Oct 1 2011, In : Nature Neuroscience. 14, 10, p. 1253-1259 7 p.

Research output: Contribution to journalArticle

133 Scopus citations

Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation

daCosta, C. J. P., Free, C. R., Corradi, J., Bouzat, C. & Sine, S. M., Sep 28 2011, In : Journal of Neuroscience. 31, 39, p. 13870-13879 10 p.

Research output: Contribution to journalArticle

47 Scopus citations
2010

Function of the acetylcholine receptor at the atomic scale

Wang, H. L. & Sine, S. M., Dec 1 2010, In : Journal of Computational and Theoretical Nanoscience. 7, 12, p. 2538-2542 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

On the origin of ion selectivity in the Cys-loop receptor family

Sine, S. M., Wang, H. L., Hansen, S. & Taylor, P., Jan 1 2010, In : Journal of Molecular Neuroscience. 40, 1-2, p. 70-76 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

What have we learned from the congenital myasthenic syndromes

Engel, A. G., Shen, X. M., Selcen, D. & Sine, S. M., Jan 1 2010, In : Journal of Molecular Neuroscience. 40, 1-2, p. 143-153 11 p.

Research output: Contribution to journalArticle

71 Scopus citations
2009

Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to Pre-M1 and M2-M3 regions

Lee, W. Y., Free, C. R. & Sine, S. M., Mar 11 2009, In : Journal of Neuroscience. 29, 10, p. 3189-3199 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

Detection and trapping of intermediate states priming nicotinic receptor channel opening

Mukhtasimova, N., Lee, W. Y., Wang, H. L. & Sine, S. M., May 21 2009, In : Nature. 459, 7245, p. 451-454 4 p.

Research output: Contribution to journalArticle

145 Scopus citations

Molecular-dynamics simulations of ELIC - A prokaryotic homologue of the nicotinic acetylcholine receptor

Cheng, X., Ivanov, I., Wang, H., Sine, S. M. & McCammon, J. A., Jan 1 2009, In : Biophysical Journal. 96, 11, p. 4502-4513 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Number and locations of agonist binding sites required to activate homomeric cys-loop receptors

Rayes, D., De Rosa, M. J., Sine, S. M. & Bouzat, C., May 6 2009, In : Journal of Neuroscience. 29, 18, p. 6022-6032 11 p.

Research output: Contribution to journalArticle

88 Scopus citations

Single-channel current through nicotinic receptor produced by closure of binding site C-loop

Wang, H. L., Toghraee, R., Papke, D., Cheng, X. L., McCammon, J. A., Ravaioli, U. & Sine, S. M., Jan 1 2009, In : Biophysical Journal. 96, 9, p. 3582-3590 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
2008

An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance

Hansen, S. B., Wang, H. L., Taylor, P. & Sine, S. M., Dec 26 2008, In : Journal of Biological Chemistry. 283, 52, p. 36066-36070 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Congenital myasthenia-related AChR δ subunit mutation interferes with intersubunit communication essential for channel gating

Shen, X. M., Fukuda, T., Ohno, K., Sine, S. M. & Engel, A. G., May 1 2008, In : Journal of Clinical Investigation. 118, 5, p. 1867-1876 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Control of cation permeation through the nicotinic receptor channel

Wang, H. L., Cheng, X., Taylor, P., McCammon, J. A. & Sine, S. M., Feb 1 2008, In : PLoS computational biology. 4, 2

Research output: Contribution to journalArticle

46 Scopus citations

Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine α3β2 receptors

Wu, T. Y., Smith, C. M., Sine, S. M. & Levandoski, M. M., Aug 1 2008, In : Molecular pharmacology. 74, 2, p. 466-475 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Nicotinic receptor interloop proline anchors β1-β2 and Cys loops in coupling agonist binding to channel gating

Lee, W. Y., Free, C. R. & Sine, S. M., Aug 1 2008, In : Journal of General Physiology. 132, 2, p. 265-278 14 p.

Research output: Contribution to journalArticle

41 Scopus citations

The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization

Bouzat, C., Bartos, M., Corradi, J. & Sine, S. M., Jul 30 2008, In : Journal of Neuroscience. 28, 31, p. 7808-7819 12 p.

Research output: Contribution to journalArticle

85 Scopus citations
2007

An intersubunit trigger of channel gating in the muscle nicotinic receptor

Mukhtasimova, N. & Sine, S. M., Apr 11 2007, In : Journal of Neuroscience. 27, 15, p. 4110-4119 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Barriers to ion translocation in cationic and anionic receptors from the cys-loop family

Ivanov, I., Cheng, X., Sine, S. M. & McCammon, J. A., Jul 4 2007, In : Journal of the American Chemical Society. 129, 26, p. 8217-8224 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Nanosecond-timescale conformational dynamics of the human α7 nicotinic acetylcholine receptor

Cheng, X., Ivanov, I., Wang, H., Sine, S. M. & McCammon, J. A., Oct 2007, In : Biophysical Journal. 93, 8, p. 2622-2634 13 p.

Research output: Contribution to journalArticle

56 Scopus citations
2006

Slow-channel mutation in acetylcholine receptor αM4 domain and its efficient knockdown

Shen, X. M., Deymeer, F., Sine, S. M. & Engel, A. G., Jul 1 2006, In : Annals of neurology. 60, 1, p. 128-136 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-Loop

Gao, F., Mer, G., Tonelli, M., Hansen, S. B., Burghardt, T. P., Taylor, P. & Sine, S. M., Sep 28 2006, In : Molecular pharmacology. 70, 4, p. 1230-1235 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors

Cheng, X., Wang, H., Grant, B., Sine, S. M. & McCammon, J. A., Oct 9 2006, In : PLoS computational biology. 2, 9, p. 1173-1184 12 p.

Research output: Contribution to journalArticle

97 Scopus citations
2005

Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence

Gao, F., Bren, N., Burghardt, T. P., Hansen, S., Henchman, R. H., Taylor, P., McCammon, J. A. & Sine, S. M., Mar 4 2005, In : Journal of Biological Chemistry. 280, 9, p. 8443-8451 9 p.

Research output: Contribution to journalArticle

114 Scopus citations

Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor

Mukhtasimova, N., Free, C. & Sine, S. M., Jul 1 2005, In : Journal of General Physiology. 126, 1, p. 23-39 17 p.

Research output: Contribution to journalArticle

90 Scopus citations

Ligand-induced conformational change in the α7 nicotinic receptor ligand binding domain

Henchman, R. H., Wang, H. L., Sine, S. M., Taylor, P. & McCammon, J. A., Apr 2005, In : Biophysical Journal. 88, 4, p. 2564-2576 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

Principal pathway coupling agonist binding to channel gating in nicotinic receptors

Lee, W. Y. & Sine, S. M., Nov 10 2005, In : Nature. 438, 7065, p. 243-247 5 p.

Research output: Contribution to journalArticle

226 Scopus citations

Single-channel kinetic analysis of chimeric α7-5HT3A receptors

Rayes, D., Spitzmaul, G., Sine, S. M. & Bouzat, C., Nov 1 2005, In : Molecular pharmacology. 68, 5, p. 1475-1483 9 p.

Research output: Contribution to journalArticle

35 Scopus citations