Saravut (John) Weroha, MD, PhD

  • 1016 Citations
  • 15 Scopus h-Index
20012019
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Research Output 2001 2019

  • 1016 Citations
  • 15 Scopus h-Index
  • 37 Article
  • 2 Review article
  • 1 Letter
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Article
2019
3 Citations (Scopus)

EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis

Zhao, Y., Ding, L., Wang, D., Ye, Z., He, Y., Ma, L., Zhu, R., Pan, Y., Wu, Q., Pang, K., Hou, X., Weroha, S. J., Han, C., Coleman, R., Coleman, I., Karnes, R. J., Zhang, J., Nelson, P. S., Wang, L. & Huang, H., Jan 1 2019, In : EMBO Journal. e99599.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Growth
Protein Biosynthesis
Neoplasms
RNA Sequence Analysis
1 Citation (Scopus)

Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-derived xenografts

Liu, Y., Chanana, P., Davila, J. I., Hou, X., Zanfagnin, V., McGehee, C. D., Goode, E. L., Polley, E., Haluska, P., Weroha, S. J. & Wang, C., Dec 1 2019, In : Scientific reports. 9, 1, 6314.

Research output: Contribution to journalArticle

Open Access
Heterografts
Ovarian Neoplasms
Gene Expression
Neoplasms
Tissue Donors

Genes associated with bowel metastases in ovarian cancer

Mariani, A., Wang, C., Oberg, A. L., Riska, S. M., Torres, M., Kumka, J., Multinu, F., Sagar, G., Roy, D., Jung, DB. B., Zhang, Q., Grassi, T., Visscher, D. W., Patel, V. P., Jin, L., Staub, J. K., Cliby, W. A., Weroha, S. J., Kalli, K. R., Hartmann, L. C. & 3 others, Kaufmann, S. H., Goode, E. L. & Shridhar, V., Jan 1 2019, In : Gynecologic oncology.

Research output: Contribution to journalArticle

Open Access
Ovarian Neoplasms
Neoplasm Metastasis
Genes
Neoplasms
Immunohistochemistry

Prospective Validation of an Ex Vivo, Patient-Derived 3D Spheroid Model for Response Predictions in Newly Diagnosed Ovarian Cancer

Shuford, S., Wilhelm, C., Rayner, M., Elrod, A., Millard, M., Mattingly, C., Lotstein, A., Smith, A. M., Guo, Q. J., O’Donnell, L., Elder, J., Puls, L., Weroha, S. J., Hou, X., Zanfagnin, V., Nick, A., Stany, M. P., Maxwell, G. L., Conrads, T., Sood, A. K. & 5 others, Orr, D., Holmes, L. M., Gevaert, M., Crosswell, H. E. & DesRochers, T. M., Dec 1 2019, In : Scientific reports. 9, 1, 11153.

Research output: Contribution to journalArticle

Open Access
Ovarian Neoplasms
Therapeutics
Recurrence
Survival
Population
2018

Chemotherapy Acute Infusion Reactions: A Qualitative Report of the Perspectives of Patients With Cancer

Bartlett, D. J., Childs, D. S., Radecki Breitkopf, C., Grudem, M. E., Mitchell, J. L., Looker, S. A., Ridgeway, J. L., Lee, J. L., Butterfield, J. H., Weroha, S. J. & Jatoi, A., Jan 1 2018, (Accepted/In press) In : American Journal of Hospice and Palliative Medicine.

Research output: Contribution to journalArticle

Drug Therapy
Fear
Neoplasms
Education
Paclitaxel
10 Citations (Scopus)

Constitutive Interferon Pathway Activation in Tumors as an Efficacy Determinant Following Oncolytic Virotherapy

Kurokawa, C., Iankov, I. D., Anderson, S. K., Aderca, I., Leontovich, A. A., Maurer, M. J., Oberg, A. L., Schroeder, M. A., Giannini, C., Greiner, S. M., Becker, M. A., Thompson, E. A., Haluska, P., Jentoft, M. E., Parney, I. F., Weroha, S. J., Jen, J., Sarkaria, J. N. & Galanis, E., Oct 1 2018, In : Journal of the National Cancer Institute. 110, 10, p. 1123-1132 10 p.

Research output: Contribution to journalArticle

Oncolytic Virotherapy
Measles virus
Interferons
Glioblastoma
Heterografts
8 Citations (Scopus)

Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer

Yan, Y., An, J., Yang, Y., Wu, D., Bai, Y., Cao, W., Ma, L., Chen, J., Yu, Z., He, Y., Jin, X., Pan, Y., Ma, T., Wang, S., Hou, X., Weroha, S. J., Karnes, R. J., Zhang, J., Westendorf, J. J., Wang, L. & 5 others, Chen, Y., Xu, W., Zhu, R., Wang, D. & Huang, H., Jan 1 2018, (Accepted/In press) In : EMBO Molecular Medicine.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Phosphorylation
Lysine
Organoids
5 Citations (Scopus)

LY2157299 monohydrate, a TGF-βR1 inhibitor, suppresses tumor growth and ascites development in ovarian cancer

Zhang, Q., Hou, X., Evans, B. J., VanBlaricom, J. L., Weroha, S. J. & Cliby, W. A., Aug 1 2018, In : Cancers. 10, 8, 260.

Research output: Contribution to journalArticle

LY-2157299
Growth and Development
Ascites
Transforming Growth Factor beta
Ovarian Neoplasms
142 Citations (Scopus)

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J., Weigand, B. M., Palmer, A. K., Weivoda, M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

Health
Tissue
Cell Aging
Quercetin
Pathology
2 Citations (Scopus)

Targeting HER2 in patient-derived xenograft ovarian cancer models sensitizes tumors to chemotherapy

Harris, F. R., Zhang, P., Yang, L., Hou, X., Leventakos, K., Weroha, S. J., Vasmatzis, G. & Kovtun, I. V., Jan 1 2018, (Accepted/In press) In : Molecular Oncology.

Research output: Contribution to journalArticle

Heterografts
Ovarian Neoplasms
Drug Therapy
Neoplasms
Therapeutics
1 Citation (Scopus)

Transcriptomic characterization of endometrioid, clear cell, and high-grade serous epithelial ovarian carcinoma

Fridley, B. L., Dai, J., Raghavan, R., Li, Q., Winham, S. J., Hou, X., Weroha, S. J., Wang, C., Kalli, K. R., Cunningham, J. M., Lawrenson, K., Gayther, S. A. & Goode, E. L., Sep 1 2018, In : Cancer Epidemiology Biomarkers and Prevention. 27, 9, p. 1101-1109 9 p.

Research output: Contribution to journalArticle

Endometrioid Carcinoma
Carcinoma
Disease-Free Survival
RNA Sequence Analysis
Gene Expression
2 Citations (Scopus)

Uterine serous carcinoma: Reassessing effectiveness of platinum-based adjuvant therapy

Tortorella, L., Langstraat, C. L., Weaver, A. L., McGree, M. E., Bakkum-Gamez, J. N., Dowdy, S. C., Cliby, W. A., Keeney, G., Sherman, M. E., Weroha, S. J., Mariani, A. & Podratz, K. C., Jan 1 2018, (Accepted/In press) In : Gynecologic Oncology.

Research output: Contribution to journalArticle

Platinum
Carcinoma
Drug Therapy
Brachytherapy
Disease-Free Survival
2017
7 Citations (Scopus)

Characterization of fusion genes in common and rare epithelial ovarian cancer histologic subtypes

Earp, M. A., Raghavan, R., Li, Q., Dai, J., Winham, S. J., Cunningham, J. M., Natanzon, Y., Kalli, K. R., Hou, X., Weroha, S. J., Haluska, P., Lawrenson, K., Gayther, S. A., Wang, C., Goode, E. L. & Fridley, B. L., 2017, In : Oncotarget. 8, 29, p. 46891-46899 9 p.

Research output: Contribution to journalArticle

Gene Fusion
Neoplasms
RNA Sequence Analysis
Ovarian epithelial cancer
Atlases
2 Citations (Scopus)

Investigation of factors affecting the efficacy of 3C23K, a human monoclonal antibody targeting MISIIR

Gill, S. E., Zhang, Q., Keeney, G., Cliby, W. A. & Weroha, S. J., Oct 17 2017, In : Oncotarget. 8, 49, p. 85214-85223 10 p.

Research output: Contribution to journalArticle

Heterografts
Ovarian Neoplasms
Monoclonal Antibodies
Antibody-Dependent Cell Cytotoxicity
Anti-Idiotypic Antibodies
19 Citations (Scopus)

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis

Zhu, S., Zhang, X., Weichert-Leahey, N., Dong, Z., Zhang, C., Lopez, G., Tao, T., He, S., Wood, A. C., Oldridge, D., Ung, C. Y., van Ree, J. H., Khan, A., Salazar, B. M., Lummertz da Rocha, E., Zimmerman, M. W., Guo, F., Cao, H., Hou, X., Weroha, S. J. & 8 others, Perez-Atayde, A. R., Neuberg, D. S., Meves, A., Mc Niven, M. A., Van Deursen, J., Li, H., Maris, J. M. & Look, A. T., Sep 11 2017, In : Cancer Cell. 32, 3, p. 310-323.e5

Research output: Contribution to journalArticle

Neuroblastoma
Neoplasm Metastasis
Zebrafish
Oncogenes
Extracellular Matrix
15 Citations (Scopus)

Loss of FOXO1 cooperates with TMPRSS2–ERG overexpression to promote prostate tumorigenesis and cell invasion

Yang, Y., Blee, A. M., Wang, D., An, J., Pan, Y., Yan, Y., Ma, T., He, Y., Dugdale, J., Hou, X., Zhang, J., Weroha, S. J., Zhu, W. G., Wang, Y. A., DePinho, R. A., Xu, W. & Huang, H., Dec 1 2017, In : Cancer Research. 77, 23, p. 6524-6537 14 p.

Research output: Contribution to journalArticle

Prostate
Prostatic Neoplasms
Carcinogenesis
Transgenes
Prostatic Intraepithelial Neoplasia
12 Citations (Scopus)

PDX-MI: Minimal information for patient-derived tumor xenograft models

Meehan, T. F., Conte, N., Goldstein, T., Inghirami, G., Murakami, M. A., Brabetz, S., Gu, Z., Wiser, J. A., Dunn, P., Begley, D. A., Krupke, D. M., Bertotti, A., Bruna, A., Brush, M. H., Byrne, A. T., Caldas, C., Christie, A. L., Clark, D. A., Dowst, H., Dry, J. R. & 34 others, Doroshow, J. H., Duchamp, O., Evrard, Y. A., Ferretti, S., Frese, K. K., Goodwin, N. C., Greenawalt, D., Haendel, M. A., Hermans, E., Houghton, P. J., Jonkers, J., Kemper, K., Khor, T. O., Lewis, M. T., Lloyd, K. C. K., Mason, J., Medico, E., Neuhauser, S. B., Olson, J. M., Peeper, D. S., Rueda, O. M., Seong, J. K., Trusolino, L., Vinolo, E., Wechsler-Reya, R. J., Weinstock, D. M., Welm, A., Weroha, S. J., Amant, F., Pfister, S. M., Kool, M., Parkinson, H., Butte, A. J. & Bult, C. J., Nov 1 2017, In : Cancer Research. 77, 21, p. e62-e66

Research output: Contribution to journalArticle

Heterografts
Neoplasms
Research
Computer Communication Networks
Aptitude
5 Citations (Scopus)

Phase 2 trial of everolimus and letrozole in relapsed estrogen receptor-positive high-grade ovarian cancers

Colon-Otero, G., Weroha, S. J., Foster, N. R., Haluska, P., Hou, X., Wahner Hendrickson, A. E., Jatoi, A., Block, M. S., Dinh, T. A., Robertson, M. W. & Copland, J. A. III., Jul 1 2017, In : Gynecologic Oncology. 146, 1, p. 64-68 5 p.

Research output: Contribution to journalArticle

letrozole
Estrogen Receptors
Ovarian Neoplasms
Heterografts
Neoplasms
9 Citations (Scopus)

Prevention of Human Lymphoproliferative Tumor Formation in Ovarian Cancer Patient-Derived Xenografts

Butler, K. A., Hou, X., Becker, M. A., Zanfagnin, V., Enderica-Gonzalez, S., Visscher, D. W., Kalli, K. R., Tienchaianada, P., Haluska, P. & Weroha, S. J., Aug 1 2017, In : Neoplasia (United States). 19, 8, p. 628-636 9 p.

Research output: Contribution to journalArticle

Heterografts
Ovarian Neoplasms
Lymphoma
Severe Combined Immunodeficiency
Neoplasms
2016
17 Citations (Scopus)

In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma

AlHilli, M. M., Becker, M. A., Weroha, S. J., Flatten, K. S., Hurley, R. M., Harrell, M. I., Oberg, A. L., Maurer, M. J., Hawthorne, K. M., Hou, X., Harrington, S. C., McKinstry, S., Meng, X. W., Wilcoxen, K. M., Kalli, K. R., Swisher, E. M., Kaufmann, S. H. & Haluska, P., Nov 1 2016, In : Gynecologic Oncology. 143, 2, p. 379-388 10 p.

Research output: Contribution to journalArticle

Homologous Recombination
Carcinoma
Heterografts
Neoplasms
Mutation
5 Citations (Scopus)

Ridaforolimus (MK-8669) synergizes with Dalotuzumab (MK-0646) in hormone-sensitive breast cancer

Becker, M. A., Hou, X., Tienchaianada, P., Haines, B. B., Harrington, S. C., Weroha, S. J., Sathyanarayanan, S. & Haluska, P., Oct 20 2016, In : BMC Cancer. 16, 1, 814.

Research output: Contribution to journalArticle

Somatomedins
Linear Energy Transfer
Hormones
Estrogen Receptor alpha
Breast Neoplasms
2015
8 Citations (Scopus)

Conventional chemotherapy and oncogenic pathway targeting in ovarian carcinosarcoma using a patient-derived tumorgraft

Glaser, G., Weroha, S. J., Becker, M. A., Hou, X., Enderica-Gonzalez, S., Harrington, S. C. & Haluska, P., May 11 2015, In : PLoS One. 10, 5, e0126867.

Research output: Contribution to journalArticle

Carcinosarcoma
Chemotherapy
Paclitaxel
drug therapy
paclitaxel

Ureteral obstruction in cancer patients: A qualitative study

Kumar, A., Mynderse, L., Patel, K., Grudem, M., Bakkum-Gamez, J. N., Longenbach, S., Block, M. S., Pitot, H. C., Garovic, V. D., Weroha, S. J. & Jatoi, A., 2015, (Accepted/In press) In : Psycho-Oncology.

Research output: Contribution to journalArticle

Percutaneous Nephrostomy
Ureteral Obstruction
Qualitative Research
Psychological Adaptation
Stents
2014
74 Citations (Scopus)

Tumorgrafts as in vivo surrogates for women with ovarian cancer

Weroha, S. J., Becker, M. A., Enderica-Gonzalez, S., Harrington, S. C., Oberg, A. L., Maurer, M. J., Perkins, S. E., AlHilli, M., Butler, K. A., McKinstry, S., Fink, S., Jenkins, R. B., Hou, X., Kalli, K. R., Goodman, K. M., Sarkaria, J. N., Karlan, B. Y., Kumar, A., Kaufmann, S. H., Hartmann, L. C. & 1 others, Haluska, P., 2014, In : Clinical Cancer Research. 20, 5, p. 1288-1297 10 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Neoplasms
SCID Mice
Fallopian Tubes
Platinum
2013
7 Citations (Scopus)

Dual HER/VEGF receptor targeting inhibits in vivo ovarian cancer tumor growth

Becker, M. A., Farzan, T., Harrington, S. C., Krempski, J. W., Weroha, S. J., Hou, X., Kalli, K. R., Wong, T. W. & Haluska, P., Dec 2013, In : Molecular Cancer Therapeutics. 12, 12, p. 2909-2916 8 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor
Ovarian Neoplasms
Growth
Neoplasms
Nude Mice
2012
24 Citations (Scopus)

IGFBP ratio confers resistance to IGF targeting and correlates with increased invasion and poor outcome in breast tumors

Becker, M. A., Hou, X., Harrington, S. C., Weroha, S. J., Gonzalez, S. E., Jacob, K. A., Carboni, J. M., Gottardis, M. M. & Haluska, P., Mar 15 2012, In : Clinical Cancer Research. 18, 6, p. 1808-1817 10 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 5
Insulin-Like Growth Factor Binding Proteins
Breast Neoplasms
Insulin-Like Growth Factor Binding Protein 4
Survival
83 Citations (Scopus)

Oncogenic pathways, molecularly targeted therapies, and highlighted clinical trials in non-small-cell lung cancer (NSCLC)

Reungwetwattana, T., Weroha, S. J. & Molina, J. R., Jul 2012, In : Clinical Lung Cancer. 13, 4, p. 252-266 15 p.

Research output: Contribution to journalArticle

Avian Sarcoma
Non-Small Cell Lung Carcinoma
Clinical Trials
Somatomedin Receptors
Mutation
27 Citations (Scopus)

Quantifying insulin receptor isoform expression in FFPE breast tumors

Harrington, S. C., Weroha, S. J., Reynolds, C., Suman, V. J., Lingle, W. L. & Haluska, P., Jun 2012, In : Growth Hormone and IGF Research. 22, 3-4, p. 108-115 8 p.

Research output: Contribution to journalArticle

Insulin Receptor
Paraffin
Formaldehyde
Protein Isoforms
Estrogen Receptors
85 Citations (Scopus)

The Insulin-Like Growth Factor System in Cancer

Weroha, S. J. & Haluska, P., Jun 2012, In : Endocrinology and Metabolism Clinics of North America. 41, 2, p. 335-350 16 p.

Research output: Contribution to journalArticle

Somatomedins
Neoplasms
Hematologic Neoplasms
Growth and Development
Carcinogenesis
2011
3 Citations (Scopus)

51-Year-old hospitalized man with a painful leg

Deimel, G. W., Weroha, S. J. & Rodriguez-Porcel, M. G., 2011, In : Mayo Clinic Proceedings. 86, 3, p. 241-244 4 p.

Research output: Contribution to journalArticle

Leg
38 Citations (Scopus)

Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma

Weroha, S. J., Oberg, A. L., Ziegler, K. L. A., Dakhilm, S. R., Rowland, K. M., Hartmann, L. C., Moore, D. F., Keeney, G., Peethambaram, P. P. & Haluska, P., Jul 2011, In : Gynecologic Oncology. 122, 1, p. 116-120 5 p.

Research output: Contribution to journalArticle

Topotecan
Platinum
Carcinoma
P-Glycoprotein
Breast Neoplasms
2010
7 Citations (Scopus)

Specific overexpression of cyclin E·CDK2 in early preinvasive and primary breast tumors in female aci rats induced by estrogen

Weroha, S. J., Lingle, W. L., Hong, Y., Li, S. A. & Li, J. J., Feb 2010, In : Hormones and Cancer. 1, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

Cyclins
Estrogens
Breast Neoplasms
Centrosome
Neoplasms
2008
133 Citations (Scopus)

IGF-1 receptor inhibitors in clinical trials - Early lessons

Weroha, S. J. & Haluska, P., 2008, In : Journal of Mammary Gland Biology and Neoplasia. 13, 4, p. 471-483 13 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Insulin-Like Growth Factor I
Clinical Trials
Breast Neoplasms
Neoplasms
2006
28 Citations (Scopus)

Overexpression of cyclins D1 and D3 during estrogen-induced breast oncogenesis in female ACI rats

Weroha, S. J., Li, S. A., Tawfik, O. & Li, J. J., Mar 2006, In : Carcinogenesis. 27, 3, p. 491-498 8 p.

Research output: Contribution to journalArticle

Cyclin D3
Cyclin D1
Human Mammary Glands
Estrogens
Carcinogenesis
2004
104 Citations (Scopus)
Centrosome
Chromosomal Instability
Estrogens
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
2002
54 Citations (Scopus)

Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: Comparison to invasive human ductal breast cancer

Li, J. J., Papa, D., Davis, M. F., Weroha, S. J., Aldaz, C. M., El-Bayoumy, K., Ballenger, J., Tawfik, O. & Li, S. A., 2002, In : Molecular Carcinogenesis. 33, 1, p. 56-65 10 p.

Research output: Contribution to journalArticle

Animal Mammary Neoplasms
Ploidies
Carcinogens
Human Mammary Glands
Hormones
2001
21 Citations (Scopus)

ER and PR in renomedullary interstitial cells during syrian hamster estrogen-induced tumorigenesis: Evidence for receptor-mediated oncogenesis

Li, J. J., Weroha, S. J., Davis, M. F., Tawfik, O., Hou, X. & Li, S. A., 2001, In : Endocrinology. 142, 9, p. 4006-4014 9 p.

Research output: Contribution to journalArticle

Mesocricetus
Estrogens
Carcinogenesis
Kidney
Cricetinae