Saravut (John) Weroha, MD, PhD

  • 1258 Citations
  • 17 Scopus h-Index
20012020

Research output per year

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Research Output

  • 1258 Citations
  • 17 Scopus h-Index
  • 39 Article
  • 5 Review article
  • 1 Letter
2020

Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer

Harrington, B. S., He, Y., Khan, T., Puttick, S., Conroy, P. J., Kryza, T., Cuda, T., Sokolowski, K. A., Tse, B. W. C., Robbins, K. K., Arachchige, B. J., Stehbens, S. J., Pollock, P. M., Reed, S., Weroha, S. J., Haluska, P., Salomon, C., Lourie, R., Perrin, L. C., Law, R. H. P. & 2 others, Whisstock, J. C. & Hooper, J. D., Jan 1 2020, In : Theranostics. 10, 5, p. 2095-2114 20 p.

Research output: Contribution to journalArticle

Open Access

Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma

Khan, T., He, Y., Kryza, T., Harrington, B. S., Gunter, J. H., Sullivan, M. A., Cuda, T., Rogers, R., Davies, C. M., Broomfield, A., Gough, M., Wu, A. C., McGann, T., Weroha, S. J., Haluska, P., Forbes, J. M., Armes, J. E., Barry, S. C., Coward, J. I., Jagasia, N. & 5 others, Chetty, N., Snell, C. E., Lourie, R., Perrin, L. C. & Hooper, J. D., Apr 2020, In : Cancers. 12, 4, 869.

Research output: Contribution to journalArticle

Open Access
2019

BRCA1 deficiency upregulates NNMT, which reprograms metabolism and sensitizes ovarian cancer cells to mitochondrial metabolic targeting agents

Kanakkanthara, A., Kurmi, K., Ekstrom, T. L., Hou, X., Purfeerst, E. R., Heinzen, E. P., Correia, C., Huntoon, C. J., O'Brien, D., Wahner Hendrickson, A. E., Dowdy, S. C., Li, H., Oberg, A. L., Hitosugi, T., Kaufmann, S. H., Weroha, S. J. & Karnitz, L. M., Dec 1 2019, In : Cancer research. 79, 23, p. 5920-5929 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis

Zhao, Y., Ding, L., Wang, D., Ye, Z., He, Y., Ma, L., Zhu, R., Pan, Y., Wu, Q., Pang, K., Hou, X., Weroha, S. J., Han, C., Coleman, R., Coleman, I., Karnes, R. J., Zhang, J., Nelson, P. S., Wang, L. & Huang, H., Mar 1 2019, In : EMBO Journal. 38, 5, e99599.

Research output: Contribution to journalArticle

7 Scopus citations

Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-derived xenografts

Liu, Y., Chanana, P., Davila, J. I., Hou, X., Zanfagnin, V., McGehee, C. D., Goode, E. L., Polley, E., Haluska, P., Weroha, S. J. & Wang, C., Dec 1 2019, In : Scientific reports. 9, 1, 6314.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Genes associated with bowel metastases in ovarian cancer

Mariani, A., Wang, C., Oberg, A. L., Riska, S. M., Torres, M., Kumka, J., Multinu, F., Sagar, G., Roy, D., Jung, DB. B., Zhang, Q., Grassi, T., Visscher, D. W., Patel, V. P., Jin, L., Staub, J. K., Cliby, W. A., Weroha, S. J., Kalli, K. R., Hartmann, L. C. & 3 others, Kaufmann, S. H., Goode, E. L. & Shridhar, V., Jan 1 2019, In : Gynecologic oncology.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A

Torres, D., Hou, X., Bale, L., Heinzen, E. P., Maurer, M. J., Zanfagnin, V., Oberg, A. L., Conover, C. & Weroha, S. J., Jan 1 2019, In : PloS one. 14, 11, e0224564.

Research output: Contribution to journalArticle

Open Access

Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models

Santiago-O'Farrill, J. M., Weroha, S. J., Hou, X., Oberg, A. L., Heinzen, E. P., Maurer, M. J., Pang, L., Rask, P., Amaravadi, R. K., Becker, S. E., Romero, I., Rubio, M. J., Matias-Guiu, X., Santacana, M., Llombart-Cussac, A., Poveda, A., Lu, Z. & Bast, R. C., Jan 1 2019, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

1 Scopus citations

Prospective Validation of an Ex Vivo, Patient-Derived 3D Spheroid Model for Response Predictions in Newly Diagnosed Ovarian Cancer

Shuford, S., Wilhelm, C., Rayner, M., Elrod, A., Millard, M., Mattingly, C., Lotstein, A., Smith, A. M., Guo, Q. J., O’Donnell, L., Elder, J., Puls, L., Weroha, S. J., Hou, X., Zanfagnin, V., Nick, A., Stany, M. P., Maxwell, G. L., Conrads, T., Sood, A. K. & 5 others, Orr, D., Holmes, L. M., Gevaert, M., Crosswell, H. E. & DesRochers, T. M., Dec 1 2019, In : Scientific reports. 9, 1, 11153.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Targeting HER2 in patient-derived xenograft ovarian cancer models sensitizes tumors to chemotherapy

Harris, F. R., Zhang, P., Yang, L., Hou, X., Leventakos, K., Weroha, S. J., Vasmatzis, G. & Kovtun, I. V., Feb 1 2019, In : Molecular Oncology. 13, 2, p. 132-152 21 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Chemotherapy Acute Infusion Reactions: A Qualitative Report of the Perspectives of Patients With Cancer

Bartlett, D. J., Childs, D. S., Radecki Breitkopf, C., Grudem, M. E., Mitchell, J. L., Looker, S. A., Ridgeway, J. L., Lee, J. L., Butterfield, J. H., Weroha, S. J. & Jatoi, A., Jan 1 2018, (Accepted/In press) In : American Journal of Hospice and Palliative Medicine.

Research output: Contribution to journalArticle

Constitutive Interferon Pathway Activation in Tumors as an Efficacy Determinant Following Oncolytic Virotherapy

Kurokawa, C., Iankov, I. D., Anderson, S. K., Aderca, I., Leontovich, A. A., Maurer, M. J., Oberg, A. L., Schroeder, M. A., Giannini, C., Greiner, S. M., Becker, M. A., Thompson, E. A., Haluska, P., Jentoft, M. E., Parney, I. F., Weroha, S. J., Jen, J., Sarkaria, J. N. & Galanis, E., Oct 1 2018, In : Journal of the National Cancer Institute. 110, 10, p. 1123-1132 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer

Yan, Y., An, J., Yang, Y., Wu, D., Bai, Y., Cao, W., Ma, L., Chen, J., Yu, Z., He, Y., Jin, X., Pan, Y., Ma, T., Wang, S., Hou, X., Weroha, S. J., Karnes, R. J., Zhang, J., Westendorf, J. J., Wang, L. & 5 others, Chen, Y., Xu, W., Zhu, R., Wang, D. & Huang, H., Jan 1 2018, (Accepted/In press) In : EMBO Molecular Medicine.

Research output: Contribution to journalArticle

12 Scopus citations

LY2157299 monohydrate, a TGF-βR1 inhibitor, suppresses tumor growth and ascites development in ovarian cancer

Zhang, Q., Hou, X., Evans, B. J., VanBlaricom, J. L., Weroha, S. J. & Cliby, W. A., Aug 1 2018, In : Cancers. 10, 8, 260.

Research output: Contribution to journalArticle

8 Scopus citations

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

252 Scopus citations

Transcriptomic characterization of endometrioid, clear cell, and high-grade serous epithelial ovarian carcinoma

Fridley, B. L., Dai, J., Raghavan, R., Li, Q., Winham, S. J., Hou, X., Weroha, S. J., Wang, C., Kalli, K. R., Cunningham, J. M., Lawrenson, K., Gayther, S. A. & Goode, E. L., Sep 1 2018, In : Cancer Epidemiology Biomarkers and Prevention. 27, 9, p. 1101-1109 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Uterine serous carcinoma: Reassessing effectiveness of platinum-based adjuvant therapy

Tortorella, L., Langstraat, C. L., Weaver, A. L., McGree, M. E., Bakkum-Gamez, J. N., Dowdy, S. C., Cliby, W. A., Keeney, G., Sherman, M. E., Weroha, S. J., Mariani, A. & Podratz, K. C., Jan 1 2018, (Accepted/In press) In : Gynecologic Oncology.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Characterization of fusion genes in common and rare epithelial ovarian cancer histologic subtypes

Earp, M. A., Raghavan, R., Li, Q., Dai, J., Winham, S. J., Cunningham, J. M., Natanzon, Y., Kalli, K. R., Hou, X., Weroha, S. J., Haluska, P., Lawrenson, K., Gayther, S. A., Wang, C., Goode, E. L. & Fridley, B. L., Jan 1 2017, In : Oncotarget. 8, 29, p. 46891-46899 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Investigation of factors affecting the efficacy of 3C23K, a human monoclonal antibody targeting MISIIR

Gill, S. E., Zhang, Q., Keeney, G., Cliby, W. A. & Weroha, S. J., Oct 17 2017, In : Oncotarget. 8, 49, p. 85214-85223 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis

Zhu, S., Zhang, X., Weichert-Leahey, N., Dong, Z., Zhang, C., Lopez, G., Tao, T., He, S., Wood, A. C., Oldridge, D., Ung, C. Y., van Ree, J. H., Khan, A., Salazar, B. M., Lummertz da Rocha, E., Zimmerman, M. W., Guo, F., Cao, H., Hou, X., Weroha, S. J. & 8 others, Perez-Atayde, A. R., Neuberg, D. S., Meves, A., McNiven, M. A., van Deursen, J. M., Li, H., Maris, J. M. & Look, A. T., Sep 11 2017, In : Cancer cell. 32, 3, p. 310-323.e5

Research output: Contribution to journalArticle

28 Scopus citations

Loss of FOXO1 cooperates with TMPRSS2–ERG overexpression to promote prostate tumorigenesis and cell invasion

Yang, Y., Blee, A. M., Wang, D., An, J., Pan, Y., Yan, Y., Ma, T., He, Y., Dugdale, J., Hou, X., Zhang, J., Weroha, S. J., Zhu, W. G., Wang, Y. A., DePinho, R. A., Xu, W. & Huang, H., Dec 1 2017, In : Cancer research. 77, 23, p. 6524-6537 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

PDX-MI: Minimal information for patient-derived tumor xenograft models

Meehan, T. F., Conte, N., Goldstein, T., Inghirami, G., Murakami, M. A., Brabetz, S., Gu, Z., Wiser, J. A., Dunn, P., Begley, D. A., Krupke, D. M., Bertotti, A., Bruna, A., Brush, M. H., Byrne, A. T., Caldas, C., Christie, A. L., Clark, D. A., Dowst, H., Dry, J. R. & 34 others, Doroshow, J. H., Duchamp, O., Evrard, Y. A., Ferretti, S., Frese, K. K., Goodwin, N. C., Greenawalt, D., Haendel, M. A., Hermans, E., Houghton, P. J., Jonkers, J., Kemper, K., Khor, T. O., Lewis, M. T., Lloyd, K. C. K., Mason, J., Medico, E., Neuhauser, S. B., Olson, J. M., Peeper, D. S., Rueda, O. M., Seong, J. K., Trusolino, L., Vinolo, E., Wechsler-Reya, R. J., Weinstock, D. M., Welm, A., Weroha, S. J., Amant, F., Pfister, S. M., Kool, M., Parkinson, H., Butte, A. J. & Bult, C. J., Nov 1 2017, In : Cancer research. 77, 21, p. e62-e66

Research output: Contribution to journalArticle

24 Scopus citations

Phase 2 trial of everolimus and letrozole in relapsed estrogen receptor-positive high-grade ovarian cancers

Colon-Otero, G., Weroha, S. J., Foster, N. R., Haluska, P., Hou, X., Wahner Hendrickson, A. E., Jatoi, A., Block, M. S., Dinh, T. A., Robertson, M. W. & Copland, J. A. III., Jul 1 2017, In : Gynecologic Oncology. 146, 1, p. 64-68 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Prevention of Human Lymphoproliferative Tumor Formation in Ovarian Cancer Patient-Derived Xenografts

Butler, K. A., Hou, X., Becker, M. A., Zanfagnin, V., Enderica-Gonzalez, S., Visscher, D. W., Kalli, K. R., Tienchaianada, P., Haluska, P. & Weroha, S. J., Aug 1 2017, In : Neoplasia (United States). 19, 8, p. 628-636 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2016

In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma

AlHilli, M. M., Becker, M. A., Weroha, S. J., Flatten, K. S., Hurley, R. M., Harrell, M. I., Oberg, A. L., Maurer, M. J., Hawthorne, K. M., Hou, X., Harrington, S. C., McKinstry, S., Meng, X. W., Wilcoxen, K. M., Kalli, K. R., Swisher, E. M., Kaufmann, S. H. & Haluska, P., Nov 1 2016, In : Gynecologic Oncology. 143, 2, p. 379-388 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Ridaforolimus (MK-8669) synergizes with Dalotuzumab (MK-0646) in hormone-sensitive breast cancer

Becker, M. A., Hou, X., Tienchaianada, P., Haines, B. B., Harrington, S. C., Weroha, S. J., Sathyanarayanan, S. & Haluska, P., Oct 20 2016, In : BMC Cancer. 16, 1, 814.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Conventional chemotherapy and oncogenic pathway targeting in ovarian carcinosarcoma using a patient-derived tumorgraft

Glaser, G., Weroha, S. J., Becker, M. A., Hou, X., Enderica-Gonzalez, S., Harrington, S. C. & Haluska, P., May 11 2015, In : PLoS One. 10, 5, e0126867.

Research output: Contribution to journalArticle

10 Scopus citations

Multi-targeted kinase inhibitor sorafenib and its future

Gil, M., Weroha, S. J., Iyer, R. & Opyrchal, M., 2015, In : Cancer and Chemotherapy Reviews. 10, 1, p. 16-24 9 p.

Research output: Contribution to journalReview article

Ureteral obstruction in cancer patients: A qualitative study

Kumar, A., Mynderse, L., Patel, K., Grudem, M., Bakkum-Gamez, J. N., Longenbach, S., Block, M. S., Pitot, H. C., Garovic, V. D., Weroha, S. J. & Jatoi, A., 2015, (Accepted/In press) In : Psycho-Oncology.

Research output: Contribution to journalArticle

2014

Tumorgrafts as in vivo surrogates for women with ovarian cancer

Weroha, S. J., Becker, M. A., Enderica-Gonzalez, S., Harrington, S. C., Oberg, A. L., Maurer, M. J., Perkins, S. E., AlHilli, M., Butler, K. A., McKinstry, S., Fink, S., Jenkins, R. B., Hou, X., Kalli, K. R., Goodman, K. M., Sarkaria, J. N., Karlan, B. Y., Kumar, A., Kaufmann, S. H., Hartmann, L. C. & 1 others, Haluska, P., Jan 1 2014, In : Clinical Cancer Research. 20, 5, p. 1288-1297 10 p.

Research output: Contribution to journalArticle

91 Scopus citations
2013

Dual HER/VEGF receptor targeting inhibits in vivo ovarian cancer tumor growth

Becker, M. A., Farzan, T., Harrington, S. C., Krempski, J. W., Weroha, S. J., Hou, X., Kalli, K. R., Wong, T. W. & Haluska, P., Dec 1 2013, In : Molecular cancer therapeutics. 12, 12, p. 2909-2916 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012

IGFBP ratio confers resistance to IGF targeting and correlates with increased invasion and poor outcome in breast tumors

Becker, M. A., Hou, X., Harrington, S. C., Weroha, S. J., Gonzalez, S. E., Jacob, K. A., Carboni, J. M., Gottardis, M. M. & Haluska, P., Mar 15 2012, In : Clinical Cancer Research. 18, 6, p. 1808-1817 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Oncogenic pathways, molecularly targeted therapies, and highlighted clinical trials in non-small-cell lung cancer (NSCLC)

Reungwetwattana, T., Weroha, S. J. & Molina, J. R., Jul 1 2012, In : Clinical lung cancer. 13, 4, p. 252-266 15 p.

Research output: Contribution to journalReview article

90 Scopus citations

Quantifying insulin receptor isoform expression in FFPE breast tumors

Harrington, S. C., Weroha, S. J., Reynolds, C., Suman, V. J., Lingle, W. L. & Haluska, P., Jun 1 2012, In : Growth Hormone and IGF Research. 22, 3-4, p. 108-115 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

The Insulin-Like Growth Factor System in Cancer

Weroha, S. J. & Haluska, P., Jun 1 2012, In : Endocrinology and Metabolism Clinics of North America. 41, 2, p. 335-350 16 p.

Research output: Contribution to journalReview article

103 Scopus citations
2011

51-Year-old hospitalized man with a painful leg

Deimel, G. W., Weroha, J. S. & Rodriguez-Porcel, M., Mar 2011, In : Mayo Clinic proceedings. 86, 3, p. 241-244 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma

Weroha, S. J., Oberg, A. L., Ziegler, K. L. A., Dakhilm, S. R., Rowland, K. M., Hartmann, L. C., Moore, D. F., Keeney, G. L., Peethambaram, P. P. & Haluska, P., Jul 1 2011, In : Gynecologic oncology. 122, 1, p. 116-120 5 p.

Research output: Contribution to journalArticle

40 Scopus citations
2010

Letter to the editor

Weroha, S. J. & Quevedo, J. F., Jun 1 2010, In : Medical Oncology. 27, 2, 1 p.

Research output: Contribution to journalLetter

Specific overexpression of cyclin E·CDK2 in early preinvasive and primary breast tumors in female aci rats induced by estrogen

Weroha, S. J., Lingle, W. L., Hong, Y., Li, S. A. & Li, J. J., Feb 1 2010, In : Hormones and Cancer. 1, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2008

IGF-1 receptor inhibitors in clinical trials - Early lessons

Weroha, S. J. & Haluska, P., Nov 20 2008, In : Journal of Mammary Gland Biology and Neoplasia. 13, 4, p. 471-483 13 p.

Research output: Contribution to journalReview article

136 Scopus citations
2006

Overexpression of cyclins D1 and D3 during estrogen-induced breast oncogenesis in female ACI rats

Weroha, J. S., Li, S. A., Tawfik, O. & Li, J. J., Mar 1 2006, In : Carcinogenesis. 27, 3, p. 491-498 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2004
105 Scopus citations
2002

Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: Comparison to invasive human ductal breast cancer

Li, J. J., Papa, D., Davis, M. F., Weroha, S. J., Aldaz, C. M., El-Bayoumy, K., Ballenger, J., Tawfik, O. & Li, S. A., Jan 21 2002, In : Molecular Carcinogenesis. 33, 1, p. 56-65 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Prevention of solely estrogen-induced mammary tumors in female ACI rats by tamoxifen: Evidence for estrogen receptor mediation

Li, S. A., Weroha, S. J., Tawfik, O. & Li, J. J., Nov 1 2002, In : Journal of Endocrinology. 175, 2, p. 297-305 9 p.

Research output: Contribution to journalReview article

55 Scopus citations
2001

ER and PR in renomedullary interstitial cells during syrian hamster estrogen-induced tumorigenesis: Evidence for receptor-mediated oncogenesis

Li, J. J., Weroha, S. J., Davis, M. F., Tawfik, O., Hou, X. & Li, S. A., Jan 1 2001, In : Endocrinology. 142, 9, p. 4006-4014 9 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations