Robert B Diasio, MD

Professor

  • 13125 Citations
  • 63 h-Index
1965 …2019
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Fluorouracil Medicine & Life Sciences
Dihydrouracil Dehydrogenase (NADP) Medicine & Life Sciences
Dihydropyrimidine Dehydrogenase Deficiency Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Drug Therapy Medicine & Life Sciences
Pharmacogenetics Medicine & Life Sciences
Antineoplastic Antimetabolites Medicine & Life Sciences
Thymidine Phosphorylase Medicine & Life Sciences

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Projects 1978 2019

CANCER CENTER SUPPORT GRANT (COMPREHENSIVE)

David, C. S., Jenkins, R. B., Cunningham, J. M., Wettstein, P. J., Buckner, J. C., Lingle, W. L., Kocher, J., Highsmith, W. E. J., Beebe, T. J., Vile, R. G., Okuno, S. H., Sarkaria, J. N., Alberts, S. R., Salisbury, J. L., Van Deursen, J., Diasio, R. B., Sargent, D. J., Thibodeau, S. N., Ingle, J. N., Reid, J. M., Colon-Otero, G., Galanis, E., Weinshilboum, R. M., Jenkins, R. B., Banks, P., Flotte, T., Kwon, E. D., Federspiel, M. J., Pitot, H. C., Dewald, G., Held, K., Liebson, P., Banks, P., Prendergast, F., Weiland, L., Wiebeu, E., Moertel, C., Clapham, D., Burnham, N., O'Connell, M., Spelsburg, T., Maihle, N., Katzmann, J., Wieand, H., Kovach, J., Wold, L., Grendahl, D., McCormick, D., Leibson, P., O'Fallon, J., Ames, M., Kline, B., Prendergast, F., Adjei, A., Chute, C., McKean, D., Highsmith, E., Raghavakaimal, S., Pitot, H., Greipp, P., Wieben, E., Roche, P., Leibson, P., Lawson, M., Grendahl, D., McCormick, D., Ames, M., Wieben, E. D., Flotte, T. J. & Adjei, A.

National Institutes of Health

3/1/802/28/19

Project: Research projectCenter Core Grants

Neoplasms
Research
Research Personnel
Cytogenetics
Biostatistics

Screening for Decreased 5-Fluorouracil Catabolism

Diasio, R. B.

National Institutes of Health

8/31/067/31/12

Project: Research projectResearch Project

Fluorouracil
Uracil
Oxidoreductases
Breath Tests
dihydropyrimidinase
Dihydrouracil Dehydrogenase (NADP)
Thymidylate Synthase
Fluorouracil
Colorectal Neoplasms
Human Genome Project

GENETIC POLYMORPHISM OF DIHYDROPYRIMIDINE DEHYDROGENASE

Diasio, R. B.

National Institutes of Health

12/9/9311/30/06

Project: Research projectResearch Project

Dihydrouracil Dehydrogenase (NADP)
Genetic Polymorphisms
Fluorouracil
Dihydropyrimidine Dehydrogenase Deficiency
Gene Expression

MECHANISM OF TOXICITY OF FLUOROCYTOSINE AND FLUOROURACIL

Diasio, R. B.

National Institutes of Health

12/1/846/30/96

Project: Research projectMethod to Extend Research in Time (MERIT) Award, Research Project

Fluorouracil
beta-Alanine
Liver
Bile Acids and Salts
Bile

Research Output 1965 2018

  • 13125 Citations
  • 63 h-Index
  • 243 Article
  • 14 Chapter
  • 1 Comment/debate
  • 1 Review article
1 Citations

Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase

Shrestha, S., Zhang, C., Jerde, C. R., Nie, Q., Li, H., Offer, S. M. & Diasio, R. B., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Fluorouracil
Alleles
Precision Medicine
Computer Simulation

Therapeutic Drug Monitoring in Oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology Recommendations for 5-Fluorouracil Therapy

Beumer, J. H., Chu, E., Allegra, C., Tanigawara, Y., Milano, G., Diasio, R. B., Kim, T. W., Mathijssen, R. H., Zhang, L., Arnold, D., Muneoka, K., Boku, N. & Joerger, M., Jan 1 2018, (Accepted/In press) In : Clinical pharmacology and therapeutics.

Research output: Contribution to journalArticle

Drug Monitoring
Fluorouracil
Toxicology
Body Surface Area
Head and Neck Neoplasms
19 Citations

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

Amstutz, U., Henricks, L. M., Offer, S. M., Barbarino, J., Schellens, J. H. M., Swen, J. J., Klein, T. E., Mcleod, H. L., Caudle, K. E., Diasio, R. B. & Schwab, M., Jan 1 2017, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Pharmacogenetics
Genotype
Guidelines
Clinical Pharmacology
2 Citations

Drug metabolism and pancreatic cancer

Flores, J. P. E., Diasio, R. B. & Saif, M. W., 2017, In : Annals of Gastroenterology. 30, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Precision Medicine
Pharmaceutical Preparations
Costs and Cost Analysis
Therapeutics
30 Citations

Future cancer research priorities in the USA: a Lancet Oncology Commission

Jaffee, E. M., Dang, C. V., Agus, D. B., Alexander, B. M., Anderson, K. C., Ashworth, A., Barker, A. D., Bastani, R., Bhatia, S., Bluestone, J. A., Brawley, O., Butte, A. J., Coit, D. G., Davidson, N. E., Davis, M., DePinho, R. A., Diasio, R. B., Draetta, G., Frazier, A. L., Futreal, A. & 34 othersGambhir, S. S., Ganz, P. A., Garraway, L., Gerson, S., Gupta, S., Heath, J., Hoffman, R. I., Hudis, C., Hughes-Halbert, C., Ibrahim, R., Jadvar, H., Kavanagh, B., Kittles, R., Le, Q. T., Lippman, S. M., Mankoff, D., Mardis, E. R., Mayer, D. K., McMasters, K., Meropol, N. J., Mitchell, B., Naredi, P., Ornish, D., Pawlik, T. M., Peppercorn, J., Pomper, M. G., Raghavan, D., Ritchie, C., Schwarz, S. W., Sullivan, R., Wahl, R., Wolchok, J. D., Wong, S. L. & Yung, A., Nov 1 2017, In : The Lancet Oncology. 18, 11, p. e653-e706

Research output: Contribution to journalReview article

Research
Neoplasms
Precision Medicine
Radiation Oncology
National Cancer Institute (U.S.)