• 13483 Citations
  • 65 Scopus h-Index
1965 …2019
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Research Output 1965 2019

  • 13483 Citations
  • 65 Scopus h-Index
  • 244 Article
  • 15 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article
2019

Optimal Lymph Node Examination and Adjuvant Chemotherapy for Stage I Lung Cancer

Dai, J., Liu, M., Yang, Y., Li, Q., Song, N., Rocco, G., Sihoe, A. D. L., Gonzalez-Rivas, D., Suen, H. C., He, W., Duan, L., Fan, J., Zhao, D., Wang, H., Zhu, Y., Chen, C., Diasio, R. B., Jiang, G., Yang, P. & Zhang, P., Jan 1 2019, In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Lung Neoplasms
Lymph Nodes
Survival
Confidence Intervals

T4 extension alone is more predictive of better survival than a tumour size >7 cm for resected T4N0-1M0 non-small-cell lung cancer

Li, Q., Zhang, P., Wang, Y., Liu, D., Luo, L., Diasio, R. B., Yang, P. & Jiang, G., Apr 1 2019, In : European Journal of Cardio-Thoracic Surgery. 55, 4, p. 682-690 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Survival
Neoplasms
Comorbidity
Confidence Intervals
2018
4 Citations (Scopus)

Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase

Shrestha, S., Zhang, C., Jerde, C. R., Nie, Q., Li, H., Offer, S. M. & Diasio, R. B., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Fluorouracil
Alleles
Precision Medicine
Computer Simulation
5 Citations (Scopus)

Therapeutic Drug Monitoring in Oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology Recommendations for 5-Fluorouracil Therapy

Beumer, J. H., Chu, E., Allegra, C., Tanigawara, Y., Milano, G., Diasio, R. B., Kim, T. W., Mathijssen, R. H., Zhang, L., Arnold, D., Muneoka, K., Boku, N. & Joerger, M., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Drug Monitoring
Fluorouracil
Toxicology
Body Surface Area
Head and Neck Neoplasms
2017
49 Citations (Scopus)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

Amstutz, U., Henricks, L. M., Offer, S. M., Barbarino, J., Schellens, J. H. M., Swen, J. J., Klein, T. E., Mcleod, H. L., Caudle, K. E., Diasio, R. B. & Schwab, M., Jan 1 2017, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Pharmacogenetics
Genotype
Guidelines
Clinical Pharmacology
3 Citations (Scopus)

Drug metabolism and pancreatic cancer

Flores, J. P. E., Diasio, R. B. & Saif, M. W., 2017, In : Annals of Gastroenterology. 30, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Precision Medicine
Pharmaceutical Preparations
Costs and Cost Analysis
Therapeutics
10 Citations (Scopus)

Quantitative Contribution of rs75017182 to Dihydropyrimidine Dehydrogenase mRNA Splicing and Enzyme Activity

Nie, Q., Shrestha, S., Tapper, E., Trogstad-Isaacson, C., Bouchonville, K., Lee, A., Wu, R., Jerde, C., Wang, Z., Kubica, P., Offer, S. & Diasio, R. B., 2017, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Alternative Splicing
Fluorouracil
Messenger RNA
Enzymes
2016

Acquired factor VII deficiency following FOLFOX in a patient with colorectal cancer who was also DPD deficient

Saif, M. W., Wasif, K., Butler-Bowen, H., Miller, K. & Diasio, R. B., Jan 1 2016, In : Therapeutic Advances in Gastroenterology. 9, 1, p. 121-127 7 p.

Research output: Contribution to journalArticle

Factor VII Deficiency
Colorectal Neoplasms
26 Citations (Scopus)

A phosphotyrosine switch regulates organic cation transporters

Sprowl, J. A., Ong, S. S., Gibson, A. A., Hu, S., Du, G., Lin, W., Li, L., Bharill, S., Ness, R. A., Stecula, A., Offer, S. M., Diasio, R. B., Nies, A. T., Schwab, M., Cavaletti, G., Schlatter, E., Ciarimboli, G., Schellens, J. H. M., Isacoff, E. Y., Sali, A. & 4 others, Chen, T., Baker, S. D., Sparreboom, A. & Pabla, N., Mar 16 2016, In : Nature Communications. 7, 10880.

Research output: Contribution to journalArticle

transporter
Phosphotyrosine
tyrosine
oxaliplatin
Protein-Tyrosine Kinases
16 Citations (Scopus)

Association between DPYD c.1129-5923 C>G/hapB3 and severe toxicity to 5-fluorouracil-based chemotherapy in stage III colon cancer patients: NCCTG N0147 (Alliance)

Lee, A. M., Shi, Q. D., Alberts, S. R., Sargent, D. J., Sinicrope, F. A., Berenberg, E. L., Grothey, A. F., Polite, B., Chan, E., Gill, S., Kahlenberg, M. S., Nair, S. G., Shields, A. F., Goldberg, R. M. & Diasio, R. B., 2016, In : Pharmacogenetics and Genomics. 26, 3, p. 133-137 5 p.

Research output: Contribution to journalArticle

Fluorouracil
Colonic Neoplasms
Drug Therapy
Poisons
Combination Drug Therapy
10 Citations (Scopus)
Dihydropyrimidine Dehydrogenase Deficiency
Dihydrouracil Dehydrogenase (NADP)
Uridine
Fluorouracil
Toxicity
Antineoplastic Antimetabolites
Dihydropyrimidine Dehydrogenase Deficiency
Dihydrouracil Dehydrogenase (NADP)
Pharmacogenetics
Fluorouracil
3 Citations (Scopus)

Histone H3K27 trimethylation modulates 5-fluorouracil resistance by inhibiting PU.1 binding to the DPYD promoter

Wu, R., Nie, Q., Tapper, E. E., Jerde, C. R., Dunlap, G. S., Shrestha, S., Elraiyah, T. A., Offer, S. M. & Diasio, R. B., Nov 1 2016, In : Cancer Research. 76, 21, p. 6362-6373 12 p.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Fluorouracil
Histones
Antimetabolites
Neoplasms
3 Citations (Scopus)

Imatinib-induced hyperbilirubinemia with UGT1A1 (*28) promoter polymorphism: First case series in patients with gastrointestinal stromal tumor

Saif, M. W., Smith, M. H., Maloney, A. & Diasio, R. B., 2016, In : Annals of Gastroenterology. 29, 4, p. 551-556 6 p.

Research output: Contribution to journalArticle

Glucuronosyltransferase
Gastrointestinal Stromal Tumors
Uridine Diphosphate
Hyperbilirubinemia
Protein-Tyrosine Kinases
7 Citations (Scopus)

Is it finally time for a personalized medicine approach for fluorouracil-based therapies?

Offer, S. M. & Diasio, R. B., Jan 20 2016, In : Journal of Clinical Oncology. 34, 3, p. 205-207 3 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Genotyping Techniques
Dihydrouracil Dehydrogenase (NADP)
Pyrimidines
Precision Medicine
6 Citations (Scopus)

Novel Deleterious Dihydropyrimidine Dehydrogenase Variants May Contribute to 5-Fluorouracil Sensitivity in an East African Population

Elraiyah, T., Jerde, C. R., Shrestha, S., Wu, R., Nie, Q., Giama, N. H., Sarangi, V., Roberts, L. R., Offer, S. M. & Diasio, R. B., 2016, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Fluorouracil
Population
Pharmacogenetics
Haplotypes
13 Citations (Scopus)

Value, access, and cost of cancer care delivery at academic cancer centers

Nardi, E. A., Wolfson, J. A., Rosen, S. T., Diasio, R. B., Gerson, S. L., Parker, B. A., Alvarnas, J. C., Levine, H. A., Fong, Y., Weisenburger, D. D., Fitzgerald, C. L., Egan, M., Stranford, S., Carlson, R. W. & Benz, E. J., Jul 1 2016, In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 7, p. 837-847 11 p.

Research output: Contribution to journalArticle

Costs and Cost Analysis
Neoplasms
Patient-Centered Care
2015
22 Citations (Scopus)

Common oncogene mutations and novel SND1-BRAF transcript fusion in lung adenocarcinoma from never smokers

Jang, J. S., Lee, A., Li, J., Liyanage, H., Yang, Y. D., Guo, L., Asmann, Y., Li, P. W., Erickson-Johnson, M., Sakai, Y., Sun, Z. D., Jeon, H. S., Hwang, H., Bungum, A. O., Edell, E., Simon, V. A., Kopp, K. J., Eckloff, B., Oliveira, A. M., Wieben, E. D. & 6 others, Aubry, M. C., Yi, E., Wigle, D. A., Diasio, R. B., Yang, P. & Jen, J., May 18 2015, In : Scientific Reports. 5, 9755.

Research output: Contribution to journalArticle

Oncogenes
Mutation
Exons
Lung Neoplasms
Neoplasms

Erratum: Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients (Nature Communications (2015) 6 (7539) DOI: 10.1038/ncomms8539)

Ziv, E., Dean, E., Hu, D., Martino, A., Serie, D., Curtin, K., Campa, D., Aftab, B., Bracci, P., Buda, G., Zhao, Y., Caswell-Jin, J., Diasio, R. B., Dumontet, C., Dudziński, M., Fejerman, L., Greenberg, A., Huntsman, S., Jamroziak, K., Jurczyszyn, A. & 18 others, Kumar, S. K., Atanackovic, D., Glenn, M., Cannon-Albright, L. A., Jones, B., Lee, A., Marques, H., Martin, T., Martinez-Lopez, J., Rajkumar, S. V., Sainz, J., Vangsted, A. J., Watek, M., Wolf, J., Slager, S. L., Camp, N. J., Canzian, F. & Vachon, C. M., Dec 9 2015, In : Nature Communications. 6, 10203.

Research output: Contribution to journalArticle

Genes
Communication
20 Citations (Scopus)

Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients

Ziv, E., Dean, E., Hu, D., Martino, A., Serie, D., Curtin, K., Campa, D., Aftab, B., Bracci, P., Buda, G., Zhao, Y., Caswell-Jin, J., Diasio, R. B., Dumontet, C., Dudziński, M., Fejerman, L., Greenberg, A., Huntsman, S., Jamroziak, K., Jurczyszyn, A. & 18 others, Kumar, S. K., Atanackovic, D., Glenn, M., Cannon-Albright, L. A., Jones, B., Lee, A., Marques, H., Martin, T., Martinez-Lopez, J., Rajkumar, S. V., Sainz, J., Vangsted, A. J., Wątek, M., Wolf, J., Slager, S. L., Camp, N. J., Canzian, F. & Vachon, C. M., Jul 22 2015, In : Nature Communications. 6, 7539.

Research output: Contribution to journalArticle

genome
Genome-Wide Association Study
Multiple Myeloma
Genes
Survival
24 Citations (Scopus)

Polymorphisms in MIR27A associated with early-onset toxicity in fluoropyrimidine-based chemotherapy

Amstutz, U., Offer, S. M., Sistonen, J., Joerger, M., Diasio, R. B. & Largiader, C. R., May 1 2015, In : Clinical Cancer Research. 21, 9, p. 2038-2044 7 p.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Drug Therapy
Confidence Intervals
MicroRNAs
Healthy Volunteers
2014
11 Citations (Scopus)

A DPYD variant (y186c) specific to individuals of african descent in a patient with life-threatening 5-fu toxic effects: Potential for an individualized medicine approach

Saif, M. W., Lee, A. M., Offer, S. M., McConnell, K., Relias, V. & Diasio, R. B., 2014, In : Mayo Clinic Proceedings. 89, 1, p. 131-136 6 p.

Research output: Contribution to journalArticle

Precision Medicine
Poisons
Fluorouracil
Dihydrouracil Dehydrogenase (NADP)
African Americans
31 Citations (Scopus)
3' Untranslated Regions
MicroRNAs
Colonic Neoplasms
Genotype
Clinical Trials
71 Citations (Scopus)

Comparative functional analysis of dpyd variants of potential clinical relevance to dihydropyrimidine dehydrogenase activity

Offer, S. M., Fossum, C. C., Wegner, N. J., Stuflesser, A. J., Butterfield, G. L. & Diasio, R. B., Jan 5 2014, In : Cancer Research. 74, 9, p. 2545-2554 10 p.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Fluorouracil
Enzymes
Population
Uracil
71 Citations (Scopus)

DPYD variants as predictors of 5-fluorouracil toxicity in adjuvant colon cancer treatment (NCCTG N0147)

Lee, A. M., Shi, Q. D., Pavey, E., Alberts, S. R., Sargent, D. J., Sinicrope, F. A., Berenberg, J. L., Goldberg, R. M. & Diasio, R. B., Dec 1 2014, In : Journal of the National Cancer Institute. 106, 12, dju298.

Research output: Contribution to journalArticle

Fluorouracil
Colonic Neoplasms
Neutropenia
Therapeutics
Odds Ratio
14 Citations (Scopus)

Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: Implications for epigenetic therapy

Witzig, T. E., Hu, G., Offer, S. M., Wellik, L. E., Han, J. J., Stenson, M. J., Dogan, A., Diasio, R. B. & Gupta, M., 2014, In : Leukemia. 28, 1, p. 147-154 8 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Lymphoma, Large B-Cell, Diffuse
Epigenomics
Histone Code
Histone Deacetylase Inhibitors
4 Citations (Scopus)

Genetic biomarkers for fluorouracil toxicity prediction: The long road to clinical utility

Lee, A. M. & Diasio, R. B., Apr 1 2014, In : Journal of Clinical Oncology. 32, 10, p. 989-990 2 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Dihydrouracil Dehydrogenase (NADP)
Thymidylate Synthase
Deoxycytidine
Fluorouracil
17 Citations (Scopus)

HER-2/neu gene amplification in relation to expression of HER2 and HER3 proteins in patients with esophageal adenocarcinoma

Yoon, H. H., Sukov, W. R., Shi, Q. D., Sattler, C. A., Wiktor, A. E., Diasio, R. B., Wu, T. T., Jenkins, R. B. & Sinicrope, F. A., Feb 1 2014, In : Cancer. 120, 3, p. 415-424 10 p.

Research output: Contribution to journalArticle

erbB-2 Genes
Gene Amplification
Epidermal Growth Factor Receptor
Adenocarcinoma
Proteins
41 Citations (Scopus)

microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites

Offer, S. M., Butterfield, G. L., Jerde, C. R., Fossum, C. C., Wegner, N. J. & Diasio, R. B., 2014, In : Molecular Cancer Therapeutics. 13, 3, p. 742-751 10 p.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
MicroRNAs
Fluorouracil
Binding Sites
Liver
4 Citations (Scopus)

Response to "a case of 5-FU-Related severe toxicity associated with the P.Y186C DPYD Variant"

Offer, S. M. & Diasio, R. B., Feb 2014, In : Clinical Pharmacology and Therapeutics. 95, 2, p. 137 1 p.

Research output: Contribution to journalArticle

Antineoplastic Antimetabolites
Dihydrouracil Dehydrogenase (NADP)
Fluorouracil
African Americans
Neoplasms
2013
32 Citations (Scopus)

A DPYD variant (Y186C) in individuals of african ancestry is associated with reduced DPD enzyme activity

Offer, S. M., Lee, A. M., Mattison, L. K., Fossum, C., Wegner, N. J. & Diasio, R. B., Jul 2013, In : Clinical Pharmacology and Therapeutics. 94, 1, p. 158-166 9 p.

Research output: Contribution to journalArticle

Fluorouracil
African Americans
Enzymes
Dihydrouracil Dehydrogenase (NADP)
Volunteers
3 Citations (Scopus)

A phase II study of modulated-capecitabine and docetaxel in chemonaive patients with advanced non-small cell lung cancer (NSCLC)

Bertino, E. M., Bekaii-Saab, T., Fernandez, S., Diasio, R. B., Karim, N. A., Otterson, G. A. & Villalona-Calero, M. A., Jan 2013, In : Lung Cancer. 79, 1, p. 27-32 6 p.

Research output: Contribution to journalArticle

docetaxel
Dihydrouracil Dehydrogenase (NADP)
Non-Small Cell Lung Carcinoma
Leukopenia
Fatigue
202 Citations (Scopus)

Clinical pharmacogenetics implementation consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing

Caudle, K. E., Thorn, C. F., Klein, T. E., Swen, J. J., McLeod, H. L., Diasio, R. B. & Schwab, M., Dec 2013, In : Clinical Pharmacology and Therapeutics. 94, 6, p. 640-645 6 p.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Pharmacogenetics
Genotype
Guidelines
Enzymes
28 Citations (Scopus)

Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a northern european family population

Zhang, Y., Kent, J. W., Lee, A., Cerjak, D., Ali, O., Diasio, R. B., Olivier, M., Blangero, J., Carless, M. A. & Kissebah, A. H., 2013, In : BMC Medical Genomics. 6, 1, 9.

Research output: Contribution to journalArticle

Metabolic Syndrome X
Fatty Acid-Binding Proteins
Epigenomics
Methylation
Insulin
55 Citations (Scopus)

Phenotypic profiling of DPYD variations relevant to 5-fluorouracil sensitivity using real-time cellular analysis and in vitro measurement of enzyme activity

Offer, S. M., Wegner, N. J., Fossum, C., Wang, K. & Diasio, R. B., Mar 15 2013, In : Cancer Research. 73, 6, p. 1958-1968 11 p.

Research output: Contribution to journalArticle

Fluorouracil
Enzymes
Dihydrouracil Dehydrogenase (NADP)
Drug Carriers
In Vitro Techniques
14 Citations (Scopus)

Single-nucleotide polymorphism rs1052501 associated with monoclonal gammopathy of undetermined significance and multiple myeloma

Greenberg, A. J., Lee, A. M., Serie, D. J., McDonnell, S. K., Cerhan, J. R., Liebow, M., Larson, D. R., Colby, C. L., Norman, A. D., Kyle, R. A., Kumar, S. K., Rajkumar, S. V., Diasio, R. B., Slager, S. L. & Vachon, C. M., Feb 2013, In : Leukemia. 27, 2, p. 515-516 2 p.

Research output: Contribution to journalArticle

Monoclonal Gammopathy of Undetermined Significance
Protein-Serine-Threonine Kinases
Multiple Myeloma
Single Nucleotide Polymorphism
Case-Control Studies
2012
54 Citations (Scopus)

Adverse prognostic impact of intratumor heterogeneous HER2 gene amplification in patients with esophageal adenocarcinoma

Yoon, H. H., Shi, Q. D., Sukov, W. R., Lewis, M. A., Sattler, C. A., Wiktor, A. E., Wu, T. T., Diasio, R. B., Jenkins, R. B. & Sinicrope, F. A., Nov 10 2012, In : Journal of Clinical Oncology. 30, 32, p. 3932-3938 7 p.

Research output: Contribution to journalArticle

erbB-2 Genes
Gene Amplification
Adenocarcinoma
Survival
Neoplasms
124 Citations (Scopus)

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11

Australian Breast Cancer Tissue Bank Investigators, 2012, In : Human Molecular Genetics. 21, 24, p. 5373-5384 12 p., dds381.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Estrogen Receptors
Meta-Analysis
Breast Neoplasms
Single Nucleotide Polymorphism
86 Citations (Scopus)

Association of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomas

Yoon, H. H., Shi, Q. D., Sukov, W. R., Wiktor, A. E., Khan, M., Sattler, C. A., Grothey, A. F., Wu, T. T., Diasio, R. B., Jenkins, R. B. & Sinicrope, F. A., Jan 15 2012, In : Clinical Cancer Research. 18, 2, p. 546-554 9 p.

Research output: Contribution to journalArticle

erbB-2 Genes
Barrett Esophagus
Gene Amplification
Adenocarcinoma
Survival
16 Citations (Scopus)

EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women

Taga, M., Mechanic, L. E., Hagiwara, N., Vähäkangas, K. H., Bennett, W. P., Alavanja, M. C. R., Welsh, J. A., Khan, M. A., Lee, A., Diasio, R. B., Edell, E., Bungum, A., Jang, J. S., Yang, P., Jen, J. & Harris, C. C., Jun 2012, In : Cancer Epidemiology Biomarkers and Prevention. 21, 6, p. 988-992 5 p.

Research output: Contribution to journalArticle

Radon
Tobacco Smoke Pollution
Epidermal Growth Factor Receptor
Smoking
Lung
24 Citations (Scopus)

Identification of a novel percent mammographic density locus at 12q24

Stevens, K. N., Lindstrom, S., Scott, C. G., Thompson, D., Sellers, T. A., Wang, X., Wang, A., Atkinson, E., Rider, D. N., Eckel-Passow, J. E., Varghese, J. S., Audley, T., Brown, J., Leyland, J., Luben, R. N., Warren, R. M. L., Loos, R. J. F., Wareham, N. J., Li, J., Hall, P. & 34 others, Liu, J., Eriksson, L., Czene, K., Olson, J. E., Shane pankratz, V., Fredericksen, Z., Diasio, R. B., Lee, A. M., Heit, J. A., De Andrade, M., Goode, E. L., Vierkant, R. A., Cunningham, J. M., Armasu, S. M., Weinshilboum, R. M., Fridley, B. L., Batzler, A., Ingle, J. N., Boyd, N. F., Paterson, A. D., Rommens, J., Martin, L. J., Hopper, J. L., Southey, M. C., Stone, J., Apicella, C., Kraft, P., Hankinson, S. E., Hazra, A., Hunter, D. J., Easton, D. F., Couch, F. J., Tamimi, R. M. & Vachon, C. M., Jul 2012, In : Human Molecular Genetics. 21, 14, p. 3299-3305 7 p., dds158.

Research output: Contribution to journalArticle

Body Mass Index
Genetic Loci
Genome-Wide Association Study
Genes
Single Nucleotide Polymorphism
27 Citations (Scopus)

The clinical case for proton beam therapy

Foote, R. L., Stafford, S. L., Petersen, I. A., Pulido, J. S., Clarke, M. J., Schild, S. E., Garces, Y. I., Olivier, K. R., Miller, R. C., Haddock, M., Yan, E., Laack, N. N., Arndt, C. A. S., Buskirk, S. J., Miller, V. L., Brent, C. R., Kruse, J. J., Ezzell, G. A., Herman, M. G., Gunderson, L. L. & 2 others, Erlichman, C. & Diasio, R. B., Oct 22 2012, In : Radiation Oncology. 7, 1, 174.

Research output: Contribution to journalArticle

Proton Therapy
Costs and Cost Analysis
Protons
Radiotherapy
Therapeutics
2011
200 Citations (Scopus)

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptorĝ€"negative breast cancer

Haiman, C. A., Chen, G. K., Vachon, C. M., Canzian, F., Dunning, A., Millikan, R. C., Wang, X., Ademuyiwa, F., Ahmed, S., Ambrosone, C. B., Baglietto, L., Balleine, R., Bandera, E. V., Beckmann, M. W., Berg, C. D., Bernstein, L., Blomqvist, C., Blot, W. J., Brauch, H., Buring, J. E. & 110 others, Carey, L. A., Carpenter, J. E., Chang-Claude, J., Chanock, S. J., Chasman, D. I., Clarke, C. L., Cox, A., Cross, S. S., Deming, S. L., Diasio, R. B., Dimopoulos, A. M., Driver, W. R., Dünnebier, T., Durcan, L., Eccles, D., Edlund, C. K., Ekici, A. B., Fasching, P. A., Feigelson, H. S., Flesch-Janys, D., Fostira, F., Försti, A., Fountzilas, G., Gerty, S. M., Giles, G. G., Godwin, A. K., Goodfellow, P., Graham, N., Greco, D., Hamann, U., Hankinson, S. E., Hartmann, A., Hein, R., Heinz, J., Holbrook, A., Hoover, R. N., Hu, J. J., Hunter, D. J., Ingles, S. A., Irwanto, A., Ivanovich, J., John, E. M., Johnson, N., Jukkola-Vuorinen, A., Kaaks, R., Ko, Y. D., Kolonel, L. N., Konstantopoulou, I., Kosma, V. M., Kulkarni, S., Lambrechts, D., Lee, A. M., Marchand, L. L., Lesnick, T., Liu, J., Lindstrom, S., Mannermaa, A., Margolin, S., Martin, N. G., Miron, P., Montgomery, G. W., Nevanlinna, H., Nickels, S., Nyante, S., Olswold, C., Palmer, J., Pathak, H., Pectasides, D., Perou, C. M., Peto, J., Pharoah, P. D. P., Pooler, L. C., Press, M. F., Pylkäs, K., Rebbeck, T. R., Rodriguez-Gil, J. L., Rosenberg, L., Ross, E., Rüdiger, T., Silva, I. D. S., Sawyer, E., Schmidt, M. K., Schulz-Wendtland, R., Schumacher, F., Severi, G., Sheng, X., Signorello, L. B., Sinn, H. P., Stevens, K. N., Southey, M. C., Tapper, W. J., Tomlinson, I., Hogervorst, F. B. L., Wauters, E., Weaver, J., Wildiers, H., Winqvist, R., Berg, D. V. D., Wan, P., Xia, L. Y., Yannoukakos, D., Zheng, W., Ziegler, R. G., Siddiq, A., Slager, S. L., Stram, D. O., Easton, D., Kraft, P., Henderson, B. E. & Couch, F. J., Dec 2011, In : Nature Genetics. 43, 12, p. 1210-1214 5 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Alleles
Odds Ratio
Genetic Loci
58 Citations (Scopus)

Associations of common variants at 1p11.2 and 14q24.1 (RAD51l1) with breast cancer risk and heterogeneity by tumor subtype: Findings from the Breast Cancer Association Consortium

Figueroa, J. D., Garcia-Closas, M., Humphreys, M., Platte, R., Hopper, J. L., Southey, M. C., Apicella, C., Hammet, F., Schmidt, M. K., Broeks, A., Tollenaar, R. A. E. M., Van't Veer, L. J., Fasching, P. A., Beckmann, M. W., Ekici, A. B., Strick, R., Peto, J., Silva, I. D. S., Fletcher, O., Johnson, N. & 138 others, Sawyer, E., Tomlinson, I., Kerin, M., Burwinkel, B., Marme, F., Schneeweiss, A., Sohn, C., Bojesen, S., Flyger, H., Nordestgaard, B. G., Benítez, J., Milne, R. L., Arias, J. I., Zamora, M. P., Brenner, H., Müller, H., Arndt, V., Rahman, N., Turnbull, C., Seal, S., Renwick, A., Brauch, H., Justenhoven, C., Brüning, T., Ko, Y. D., Baisch, C., Fischer, H. P., Hamann, U., Pesch, B., Rabstein, S., Harth, V., Chang-Claude, J., Hein, R., Wang-Gohrke, S., Dörk, T., Schürmann, P., Bremer, M., Hillemanns, P., Nevanlinna, H., Heikkinen, T., Aittomäki, K., Blomqvist, C., Bogdanova, N., Antonenkova, N., Rogov, Y. I., Karstens, J. H., Bermisheva, M., Prokofieva, D., Gantcev, S. H., Khusnutdinova, E., Lindblom, A., Margolin, S., Chenevix-Trench, G., Beesley, J., Chen, X., Bowtell, D., Chenevix-Trench, G., deFazio, A., Gertig, D., Green, A., Webb, P. M., Mannermaa, A., Kosma, V. M., Soini, Y., Kataja, V., Lambrechts, D., Yesilyurt, B. T., Chrisiaens, M. R., Peeters, S., Radice, P., Peterlongo, P., Manoukian, S., Barile, M., Couch, F. J., Lee, A. M., Diasio, R. B., Wang, X., Giles, G. G., Severi, G., Baglietto, L., Maclean, C., Offit, K., Robson, M., Joseph, V., Gaudet, M., John, E. M., Winqvist, R., Pylkäs, K., Jukkola-Vuorinen, A., Grip, M., Andrulis, I., Knight, J. A., Mulligan, A. M., O'Malley, F. P., Brinton, L. A., Sherman, M. E., Lissowska, J., Chanock, S. J., Hooning, M., Martens, J. W. M., van den Ouweland, A. M. W., Collée, J. M., Hall, P., Czene, K., Cox, A., Brock, I. W., Reed, M. W. R., Cross, S. S., Pharoah, P., Dunning, A. M., Kang, D., Yoo, K. Y., Noh, D. Y., Ahn, S. H., Jakubowska, A., Lubinski, J., Jaworska, K., Durda, K., Sangrajrang, S., Gaborieau, V., Brennan, P., McKay, J., Shen, C. Y., Ding, S. L., Hsu, H. M., Yu, J. C., Anton-Culver, H., Ziogas, A., Ashworth, A., Swerdlow, A., Jones, M., Orr, N., Trentham-Dietz, A., Egan, K., Newcomb, P., Titus-Ernstoff, L., Easton, D. & Spurdle, A. B., Dec 2011, In : Human Molecular Genetics. 20, 23, p. 4693-4706 14 p., ddr368.

Research output: Contribution to journalArticle

Breast Neoplasms
Estrogen Receptors
Single Nucleotide Polymorphism
Neoplasms
Genome-Wide Association Study
85 Citations (Scopus)

Common breast cancer susceptibility loci are associated with triple-negative breast cancer

Stevens, K. N., Vachon, C. M., Lee, A. M., Slager, S. L., Lesnick, T., Olswold, C., Fasching, P. A., Miron, P., Eccles, D., Carpenter, J. E., Godwin, A. K., Ambrosone, C., Winqvist, R., Brauch, H., Schmidt, M. K., Cox, A., Cross, S. S., Sawyer, E., Hartmann, A., Beckmann, M. W. & 63 others, Schulz-Wendtland, R., Ekici, A. B., Tapper, W. J., Gerty, S. M., Durcan, L., Graham, N., Hein, R., Nickels, S., Flesch-Janys, D., Heinz, J., Sinn, H. P., Konstantopoulou, I., Fostira, F., Pectasides, D., Dimopoulos, A. M., Fountzilas, G., Clarke, C. L., Balleine, R., Olson, J. E., Fredericksen, Z., Diasio, R. B., Pathak, H., Ross, E., Weaver, J., Rüdiger, T., Försti, A., Dünnebier, T., Ademuyiwa, F., Kulkarni, S., Pylkäs, K., Jukkola-Vuorinen, A., Ko, Y. D., Van Limbergen, E., Janssen, H., Peto, J., Fletcher, O., Giles, G. G., Baglietto, L., Verhoef, S., Tomlinson, I., Kosma, V. M., Beesley, J., Greco, D., Blomqvist, C., Irwanto, A., Liu, J., Blows, F. M., Dawson, S. J., Margolin, S., Mannermaa, A., Martin, N. G., Montgomery, G. W., Lambrechts, D., Dos Santos Silva, I., Severi, G., Hamann, U., Pharoah, P., Easton, D. F., Chang-Claude, J., Yannoukakos, D., Nevanlinna, H., Wang, X. & Couch, F. J., Oct 1 2011, In : Cancer Research. 71, 19, p. 6240-6249 10 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Breast Neoplasms
Genome-Wide Association Study
Progesterone Receptors
Genetic Predisposition to Disease

Erratum: Pharmacokinetics of an anti-human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM 91) in HIV-infected subjects (Clinical Pharmacology and Therapeutics (1995) 58 (44-53) DOI: 10.1016/0009-9236(95)90071-3)

Zhang, R., Yan, J., Shahinian, H., Amin, G., Lu, Z., Liu, T., Saag, M. S., Jiang, Z., Temsamani, J., Martin, R. R., Schechter, P. J., Agrawal, S. & Diasio, R. B., Feb 2011, In : Clinical Pharmacology and Therapeutics. 89, 2, p. 320 1 p.

Research output: Contribution to journalArticle

Clinical Pharmacology
Oligodeoxyribonucleotides
Pharmacokinetics
HIV
Therapeutics
8 Citations (Scopus)

Methylation of the human pendrin promoter

Lee, A., Nofziger, C., Dossena, S., Vanoni, S., Diasio, R. B. & Paulmichl, M., 2011, In : Cellular Physiology and Biochemistry. 28, 3, p. 397-406 10 p.

Research output: Contribution to journalArticle

Methylation
Interleukin-4
Cell Line
Messenger RNA
Kidney
47 Citations (Scopus)

Prognostic impact of body mass index stratified by smoking status in patients with esophageal adenocarcinoma

Yoon, H. H., Lewis, M. A., Shi, Q. D., Khan, M., Cassivi, S. D., Diasio, R. B. & Sinicrope, F. A., Dec 1 2011, In : Journal of Clinical Oncology. 29, 34, p. 4561-4567 7 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Body Mass Index
Smoking
Survival
Obesity
2010
3 Citations (Scopus)

ADAM-17: A target to increase chemotherapeutic efficacy in colorectal cancer?

Lee, A. M. & Diasio, R. B., Jul 1 2010, In : Clinical Cancer Research. 16, 13, p. 3319-3321 3 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Drug Therapy
Growth Factor Receptors
Intercellular Signaling Peptides and Proteins
Ligands
230 Citations (Scopus)

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

Antoniou, A. C., Wang, X., Fredericksen, Z. S., McGuffog, L., Tarrell, R., Sinilnikova, O. M., Healey, S., Morrison, J., Kartsonaki, C., Lesnick, T., Ghoussaini, M., Barrowdale, D., Peock, S., Cook, M., Oliver, C., Frost, D., Eccles, D., Evans, D. G., Eeles, R., Izatt, L. & 158 others, Chu, C., Douglas, F., Paterson, J., Stoppa-Lyonnet, D., Houdayer, C., Mazoyer, S., Giraud, S., Lasset, C., Remenieras, A., Caron, O., Hardouin, A., Berthet, P., Hogervorst, F. B. L., Rookus, M. A., Jager, A., Van Den Ouweland, A., Hoogerbrugge, N., Van Der Luijt, R. B., Meijers-Heijboer, H., G'mez García, E. B., Devilee, P., Vreeswijk, M. P. G., Lubinski, J., Jakubowska, A., Gronwald, J., Huzarski, T., Byrski, T., G'rski, B., Cybulski, C., Spurdle, A. B., Holland, H., Goldgar, D. E., John, E. M., Hopper, J. L., Southey, M., Buys, S. S., Daly, M. B., Terry, M. B., Schmutzler, R. K., Wappenschmidt, B., Engel, C., Meindl, A., Preisler-Adams, S., Arnold, N., Niederacher, D., Sutter, C., Domchek, S. M., Nathanson, K. L., Rebbeck, T., Blum, J. L., Piedmonte, M., Rodriguez, G. C., Wakeley, K., Boggess, J. F., Basil, J., Blank, S. V., Friedman, E., Kaufman, B., Laitman, Y., Milgrom, R., Andrulis, I. L., Glendon, G., Ozcelik, H., Kirchhoff, T., Vijai, J., Gaudet, M. M., Altshuler, D., Guiducci, C., Loman, N., Harbst, K., Rantala, J., Ehrencrona, H., Gerdes, A. M., Thomassen, M., Sunde, L., Peterlongo, P., Manoukian, S., Bonanni, B., Viel, A., Radice, P., Caldes, T., De La Hoya, M., Singer, C. F., Fink-Retter, A., Greene, M. H., Mai, P. L., Loud, J. T., Guidugli, L., Lindor, N. M., Hansen, T. V. O., Nielsen, F. C., Blanco, I., Lazaro, C., Garber, J., Ramus, S. J., Gayther, S. A., Phelan, C., Narod, S., Szabo, C. I., Benitez, J., Osorio, A., Nevanlinna, H., Heikkinen, T., Caligo, M. A., Beattie, M. S., Hamann, U., Godwin, A. K., Montagna, M., Casella, C., Neuhausen, S. L., Karlan, B. Y., Tung, N., Toland, A. E., Weitzel, J., Olopade, O., Simard, J., Soucy, P., Rubinstein, W. S., Arason, A., Rennert, G., Martin, N. G., Montgomery, G. W., Chang-Claude, J., Flesch-Janys, D., Brauch, H., Severi, G., Baglietto, L., Cox, A., Cross, S. S., Miron, P., Gerty, S. M., Tapper, W., Yannoukakos, D., Fountzilas, G., Fasching, P. A., Beckmann, M. W., Dos Santos Silva, I., Peto, J., Lambrechts, D., Paridaens, R., Rüdiger, T., Försti, A., Winqvist, R., Pylkäs, K., Diasio, R. B., Lee, A. M., Eckel-Passow, J. E., Vachon, C. M., Blows, F., Driver, K., Dunning, A., Pharoah, P. P. D., Offit, K., Pankratz, V. S., Hakonarson, H., Chenevix-Trench, G., Easton, D. F. & Couch, F. J., Oct 2010, In : Nature Genetics. 42, 10, p. 885-892 8 p.

Research output: Contribution to journalArticle

Hormones
Breast Neoplasms
Mutation
Single Nucleotide Polymorphism
Population