• 4949 Citations
  • 38 Scopus h-Index
1984 …2017

Research output per year

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Research Output

2017

Chemotherapy can induce weight normalization of morbidly obese mice despite undiminished ingestion of high fat diet

Myers, C. E., Hoelzinger, D. B., Truong, T. N., Chew, L. A., Myles, A., Chaudhuri, L., Egan, J. B., Liu, J., Gendler, S. J. & Cohen, P. A., Jan 1 2017, In : Oncotarget. 8, 3, p. 5426-5438 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Myeloid-derived suppressor cell subset accumulation in renal cell carcinoma parenchyma is associated with intratumoral expression of IL1b, IL8, CXCL5, and Mip-1α

Najjar, Y. G., Rayman, P., Jia, X., Pavicic, P. G., Rini, B. I., Tannenbaum, C., Ko, J., Haywood, S., Cohen, P. A., Hamilton, T., Diaz-Montero, C. M. & Finke, J., May 1 2017, In : Clinical Cancer Research. 23, 9, p. 2346-2355 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens

Pathangey, L. B., McCurry, D. B., Gendler, S. J., Dominguez, A. L., Gorman, J. E., Pathangey, G., Mihalik, L. A., Dang, Y., Disis, M. L. & Cohen, P. A., Jan 1 2017, In : Oncotarget. 8, 7, p. 10785-10808 24 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis and Immunological Evaluation of a Multicomponent Cancer Vaccine Candidate Containing a Long MUC1 Glycopeptide

Supekar, N. T., Lakshminarayanan, V., Capicciotti, C. J., Sirohiwal, A., Madsen, C. S., Wolfert, M. A., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jan 1 2017, (Accepted/In press) In : ChemBioChem.

Research output: Contribution to journalArticle

2 Scopus citations

Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment

Weinstein, A. M., Chen, L., Brzana, E. A., Patil, P. R., Taylor, J. L., Fabian, K. L., Wallace, C. T., Jones, S. D., Watkins, S. C., Lu, B., Stroncek, D. F., Denning, T. L., Fu, Y. X., Cohen, P. A. & Storkus, W. J., Jun 3 2017, In : OncoImmunology. 6, 6, e1322238.

Research output: Contribution to journalArticle

14 Scopus citations
2016

Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Tolllike receptor agonists

Manrique, S. Z., Dominguez, A. L., Mirza, N., Spencer, C. D., Bradley, J. M., Finke, J. H., Lee, J. J., Pease, L. R., Gendler, S. J. & Cohen, P. A., 2016, In : Oncotarget. 7, 28, p. 42919-42942 24 p.

Research output: Contribution to journalArticle

13 Scopus citations

MUC1 vaccines, comprised of glycosylated or non-glycosylated peptides or tumor-derived MUC1, can circumvent immunoediting to control tumor growth in MUC1 transgenic mice

Lakshminarayanan, V., Supekar, N. T., Wei, J., McCurry, D. B., Dueck, A. C., Kosiorek, H. E., Trivedi, P. P., Bradley, J. M., Madsen, C. S., Pathangey, L. B., Hoelzinger, D. B., Wolfert, M. A., Boons, G. J., Cohen, P. A. & Gendler, S. J., Jan 1 2016, In : PloS one. 11, 1, e0145920.

Research output: Contribution to journalArticle

21 Scopus citations
2015

Late-stage cancer patients remain highly responsive to immune activation by the selective TLR8 agonist motolimod (VTX-2337)

Dietsch, G. N., Randall, T. D., Gottardo, R., Northfelt, D. W., Ramanathan, R. K., Cohen, P. A., Manjarrez, K. L., Newkirk, M., Bryan, J. K. & Hershberg, R. M., Dec 15 2015, In : Clinical Cancer Research. 21, 24, p. 5445-5452 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

Thompson, P., Lakshminarayanan, V., Supekar, N. T., Bradley, J. M., Cohen, P. A., Wolfert, M. A., Gendler, S. J. & Boons, G. J., May 28 2015, In : Chemical Communications. 51, 50, p. 10214-10217 4 p.

Research output: Contribution to journalArticle

26 Scopus citations
2014

Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma

Chodon, T., Comin-Anduix, B., Chmielowski, B., Koya, R. C., Wu, Z., Auerbach, M., Ng, C., Avramis, E., Seja, E., Villanueva, A., McCannel, T. A., Ishiyama, A., Czernin, J., Radu, C. G., Wang, X., Gjertson, D. W., Cochran, A. J., Cornetta, K., Wong, D. J. L., Kaplan-Lefko, P. & 14 others, Hamid, O., Samlowski, W., Cohen, P. A., Daniels, G. A., Mukherji, B., Yang, L., Zack, J. A., Kohn, D. B., Heath, J. R., Glaspy, J. A., Witte, O. N., Baltimore, D., Economou, J. S. & Ribas, A., May 1 2014, In : Clinical Cancer Research. 20, 9, p. 2457-2465 9 p.

Research output: Contribution to journalArticle

104 Scopus citations

A phase I dose-finding study of the novel toll-like receptor 8 agonist VTX-2337 in adult subjects with advanced solid tumors or lymphoma

Northfelt, D. W., Ramanathan, R. K., Cohen, P. A., Von Hoff, D. D., Weiss, G. J., Dietsch, G. N., Manjarrez, K. L., Randall, T. D. & Hershberg, R. M., Jul 15 2014, In : Clinical Cancer Research. 20, 14, p. 3683-3691 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Combination of sunitinib with anti-tumor vaccination inhibits T cell priming and requires careful scheduling to achieve productive immunotherapy

Jaini, R., Rayman, P., Cohen, P. A., Finke, J. H. & Tuohy, V. K., Apr 1 2014, In : International Journal of Cancer. 134, 7, p. 1695-1705 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Immune and anticancer responses elicited by fully synthetic aberrantly glycosylated MUC1 tripartite vaccines modified by a TLR2 or TLR9 agonist

Abdel-Aal, A. B. M., Lakshminarayanan, V., Thompson, P., Supekar, N., Bradley, J. M., Wolfert, M. A., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jul 7 2014, In : ChemBioChem. 15, 10, p. 1508-1513 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid t-cell sensitization and rejection of progressive tumor challenges

Hoelzinger, D. B., Dominguez, A. L., Cohen, P. A. & Gendler, S. J., Dec 1 2014, In : Cancer research. 74, 23, p. 6845-6855 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
2013

A randomized phase 2 study of temozolomide and bevacizumab or nab-paclitaxel, carboplatin, and bevacizumab in patients with unresectable stage IV melanoma: A North Central Cancer Treatment Group study, N0775

Kottschade, L. A., Suman, V. J., Perez, D. G., McWilliams, R. R., Kaur, J. S., Amatruda, T. T., Geoffroy, F. J., Gross, H. M., Cohen, P. A., Jaslowski, A. J., Kosel, M. L. & Markovic, S. N., Feb 1 2013, In : Cancer. 119, 3, p. 586-592 7 p.

Research output: Contribution to journalArticle

57 Scopus citations

Downregulation of hematopoietic MUC1 during Experimental colitis increases tumor-promoting myeloid-derived suppressor cells

Poh, T. W., Madsen, C. S., Gorman, J. E., Marler, R. J., Leighton, J. A., Cohen, P. A. & Gendler, S. J., Sep 15 2013, In : Clinical Cancer Research. 19, 18, p. 5039-5052 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Extracellular ATP and Toll-Like Receptor 2 Agonists Trigger in Human Monocytes an Activation Program That Favors T Helper 17

Paustian, C., Taylor, P., Johnson, T., Xu, M., Ramirez, N., Rosenthal, K. S., Shu, S., Cohen, P. A., Czerniecki, B. J. & Koski, G. K., Jan 31 2013, In : PloS one. 8, 1, e54804.

Research output: Contribution to journalArticle

19 Scopus citations

Modification of the tumor microenvironment as a novel target of renal cell carcinoma therapeutics

Finke, J. H., Rayman, P. A., Ko, J. S., Bradley, J. M., Gendler, S. J. & Cohen, P. A., Jul 1 2013, In : Cancer Journal (United States). 19, 4, p. 353-364 12 p.

Research output: Contribution to journalReview article

31 Scopus citations
2012

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

Lakshminarayanan, V., Thompson, P., Wolfert, M. A., Buskas, T., Bradley, J. M., Pathangey, L. B., Madsen, C. S., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jan 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 1, p. 261-266 6 p.

Research output: Contribution to journalArticle

199 Scopus citations

Myeloid-derived suppressor cells adhere to physiologic STAT3-vs STAT5-dependent hematopoietic programming, establishing diverse tumor-mediated mechanisms of immunologic escape

Cohen, P. A., Ko, J. S., Storkus, W. J., Spencer, C. D., Bradley, J. M., Gorman, J. E., McCurry, D. B., Zorro-Manrique, S., Dominguez, A. L., Pathangey, L. B., Rayman, P. A., Rini, B. I., Gendler, S. J. & Finke, J. H., Aug 1 2012, In : Immunological Investigations. 41, 6-7, p. 680-710 31 p.

Research output: Contribution to journalArticle

29 Scopus citations

Vaccines targeting tumor blood vessel antigens promote CD8 + T cell-dependent tumor eradication or dormancy in HLA-A2 transgenic mice

Zhao, X., Bose, A., Komita, H., Taylor, J. L., Chi, N., Lowe, D. B., Okada, H., Cao, Y., Mukhopadhyay, D., Cohen, P. A. & Storkus, W. J., Feb 15 2012, In : Journal of Immunology. 188, 4, p. 1782-1788 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
2011

Effect of multiple activation stimuli on the generation of Th1-polarizing dendritic cells

Paustian, C., Caspell, R., Johnson, T., Cohen, P. A., Shu, S., Xu, S., Czerniecki, B. J. & Koski, G. K., Jan 1 2011, In : Human Immunology. 72, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy

Finke, J., Ko, J., Rini, B., Rayman, P., Ireland, J. & Cohen, P., Jul 2011, In : International Immunopharmacology. 11, 7, p. 856-861 6 p.

Research output: Contribution to journalArticle

184 Scopus citations

Sunitinib facilitates the activation and recruitment of therapeutic anti-tumor immunity in concert with specific vaccination

Bose, A., Taylor, J. L., Alber, S., Watkins, S. C., Garcia, J. A., Rini, B. I., Ko, J. S., Cohen, P. A., Finke, J. H. & Storkus, W. J., Nov 1 2011, In : International Journal of Cancer. 129, 9, p. 2158-2170 13 p.

Research output: Contribution to journalArticle

96 Scopus citations
2010

Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained

Ko, J. S., Rayman, P., Ireland, J., Swaidani, S., Li, G., Bunting, K. D., Rini, B., Finke, J. H. & Cohen, P. A., May 1 2010, In : Cancer research. 70, 9, p. 3526-3536 11 p.

Research output: Contribution to journalArticle

203 Scopus citations

Immunotherapy using allogeneic squamous cell tumor-dendritic cell fusion hybrids

Lee, W. T., Tan, C., Koski, G., Shu, S. & Cohen, P., Sep 1 2010, In : Head and Neck. 32, 9, p. 1209-1216 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

J-LEAPS vaccines initiate murine Th1 responses by activating dendritic cells

Taylor, P. R., Koski, G. K., Paustian, C. C., Bailey, E., Cohen, P. A., Moore, F. B. G., Zimmerman, D. H. & Rosenthal, K. S., Aug 1 2010, In : Vaccine. 28, 34, p. 5533-5542 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Toll-like receptor agonists as third signals for dendritic cell-tumor fusion vaccines

Cho, E. I., Tan, C., Koski, G. K., Cohen, P. A., Shu, S. & Lee, W. T., Jun 1 2010, In : Head and Neck. 32, 6, p. 700-707 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
2009

Interferons and interleukin-2: Molecular basis of activity and therapeutic results

Hutson, T. E., Thakkar, S., Cohen, P. & Borden, E. C., Dec 1 2009, Renal Cell Carcinoma: Molecular Targets and Clinical Applications. Humana Press, p. 49-78 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients

Ko, J. S., Zea, A. H., Rini, B. I., Ireland, J. L., Elson, P., Cohen, P., Golshayan, A., Rayman, P. A., Wood, L., Garcia, J., Dreicer, R., Bukowski, R. & Finke, J. H., Mar 15 2009, In : Clinical Cancer Research. 15, 6, p. 2148-2157 10 p.

Research output: Contribution to journalArticle

586 Scopus citations
2008

Effective treatment of spontaneous metastases derived from a poorly immunogenic murine mammary carcinoma by combined dendritic-tumor hybrid vaccination and adoptive transfer of sensitized T cells

Tamai, H., Watanabe, S., Zheng, R., Deguchi, K., Cohen, P. A., Koski, G. K. & Shu, S., Apr 1 2008, In : Clinical Immunology. 127, 1, p. 66-77 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Immunotherapy of established murine squamous cell carcinoma using fused dendritic-tumor cell hybrids

Lee, W. T., Tamai, H., Cohen, P., Teker, A. M. & Shu, S., Jun 1 2008, In : Archives of Otolaryngology - Head and Neck Surgery. 134, 6, p. 608-613 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Paired toll-like receptor agonists enhance vaccine therapy through induction of interleukin-12

Zheng, R., Cohen, P. A., Paustian, C. A., Johnson, T. D., Lee, W. T., Shu, S. & Koski, G. K., Jun 1 2008, In : Cancer research. 68, 11, p. 4045-4049 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

Reengineering dendritic cell-based anti-cancer vaccines

Koski, G. K., Cohen, P. A., Roses, R. E., Xu, S. & Czerniecki, B. J., Apr 1 2008, In : Immunological Reviews. 222, 1, p. 256-276 21 p.

Research output: Contribution to journalReview article

49 Scopus citations

STAT3-And STAT5-dependent pathways competitively regulate the pan-differentiation of CD34 pos cells into tumor-competent dendritic cells

Cohen, P. A., Koski, G. K., Czerniecki, B. J., Bunting, K. D., Fu, X. Y., Wang, Z., Zhang, W. J., Carter, C. S., Awad, M., Distel, C. A., Nagem, H., Paustian, C. C., Johnson, T. D., Tisdale, J. F. & Shu, S., Sep 1 2008, In : Blood. 112, 5, p. 1832-1843 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Tumor-induced CD11b+Gr-1+ myeloid cells suppress T cell sensitization in tumor-draining lymph nodes

Watanabe, S., Deguchi, K., Zheng, R., Tamai, H., Wang, L. X., Cohen, P. A. & Shu, S., Sep 1 2008, In : Journal of Immunology. 181, 5, p. 3291-3300 10 p.

Research output: Contribution to journalArticle

Open Access
90 Scopus citations
2007

Immunogenicity of dendritic-tumor fusion hybrids and their utility in cancer immunotherapy

Shu, S., Zheng, R., Lee, W. T. & Cohen, P. A., Dec 1 2007, In : Critical reviews in immunology. 27, 5, p. 463-483 21 p.

Research output: Contribution to journalReview article

24 Scopus citations

Improving immunotherapy by conditionally enhancing MHC class I presentation of tumor antigen-derived peptide epitopes

Storkus, W. J., Herrem, C., Kawabe, M., Cohen, P. A., Bukowski, R. M., Finke, J. H. & Wesa, A. K., Jan 1 2007, In : Critical reviews in immunology. 27, 5, p. 485-493 9 p.

Research output: Contribution to journalReview article

11 Scopus citations

Significance of regional draining lymph nodes in the development of tumor immunity: implications for cancer immunotherapy.

Zheng, R., Kjaergaard, J., Lee, W. T., Cohen, P. A. & Shu, S., 2007, In : Cancer treatment and research. 135, p. 223-237 15 p.

Research output: Contribution to journalReview article

9 Scopus citations

Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion

Czerniecki, B. J., Koski, G. K., Koldovsky, U., Xu, S., Cohen, P. A., Mick, R., Nisenbaum, H., Pasha, T., Xu, M., Fox, K. R., Weinstein, S., Orel, S. G., Vonderheide, R., Coukos, G., DeMichele, A., Araujo, L., Spitz, F. R., Rosen, M., Levine, B. L., June, C. & 1 others, Zhang, P. J., Feb 15 2007, In : Cancer research. 67, 4, p. 1842-1852 11 p.

Research output: Contribution to journalArticle

191 Scopus citations
2006

Mechanism of third signals provided by IL-12 and OX-40R ligation in eliciting therapeutic immunity following dendritic-tumor fusion vaccination

Kuriyama, H., Watanabe, S., Kjaergaard, J., Tamai, H., Zheng, R., Weinberg, A. D., Hu, H. M., Cohen, P. A., Plautz, G. E. & Shu, S., Dec 1 2006, In : Cellular Immunology. 243, 1, p. 30-40 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2004

Adoptive immunotherapy of cancer with polyclonal, 108-fold hyperexpanded, CD4+ and CD8+T cells

Wang, L. X., Huang, W. X., Graor, H., Cohen, P. A., Kim, J. A., Shu, S. & Plautz, G. E., Nov 26 2004, In : Journal of Translational Medicine. 2

Research output: Contribution to journalArticle

24 Scopus citations

Cutting Edge: Innate Immune System Discriminates between RNA Containing Bacterial versus Eukaryotic Structural Features That Prime for High-Level, IL-12 Secretion by Dendritic Cells

Koski, G. K., Karikó, K., Xu, S., Weissman, D., Cohen, P. A. & Czerniecki, B. J., Apr 1 2004, In : Journal of Immunology. 172, 7, p. 3989-3993 5 p.

Research output: Contribution to journalArticle

Open Access
83 Scopus citations

Memory T Cells Originate from Adoptively Transferred Effectors and Reconstituting Host Cells after Sequential Lymphodepletion and Adoptive Immunotherapy

Wang, L. X., Kjaergaard, J., Cohen, P. A., Shu, S. & Plautz, G. E., Mar 15 2004, In : Journal of Immunology. 172, 6, p. 3462-3468 7 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Therapeutic vaccine generated by electrofusion of dendritic cells and tumour cells.

Kuriyama, H., Shimizu, K., Lee, W., Kjaergaard, J., Parkhurst, M. R., Cohen, P. A. & Shu, S., 2004, In : Developments in biologicals. 116, p. 169-178; discussion 179-186

Research output: Contribution to journalArticle

15 Scopus citations
2003

Considerations on clinical use of T cell immunotherapy for cancer

Plautz, G. E., Cohen, P. A. & Shu, S., Sep 5 2003, In : Archivum Immunologiae et Therapiae Experimentalis. 51, 4, p. 245-257 13 p.

Research output: Contribution to journalReview article

10 Scopus citations

Intranodal administration of peptide-pulsed mature dendritic cell vaccines results in superior CD8+ T-cell function in melanoma patients

Bedrosian, I., Mick, R., Xu, S., Nisenbaum, H., Faries, M., Zhang, P., Cohen, P. A., Koski, G. & Czerniecki, B. J., Oct 15 2003, In : Journal of Clinical Oncology. 21, 20, p. 3826-3835 10 p.

Research output: Contribution to journalArticle

144 Scopus citations

Rapid high efficiency sensitization of CD8+ T cells to tumor antigens by dendritic cells leads to enhanced functional avidity and direct tumor recognition through an IL-12-dependent mechanism

Xu, S., Koski, G. K., Faries, M., Bedrosian, I., Mick, R., Maeurer, M., Cheever, M. A., Cohen, P. A. & Czerniecki, B. J., Sep 1 2003, In : Journal of Immunology. 171, 5, p. 2251-2261 11 p.

Research output: Contribution to journalArticle

Open Access
118 Scopus citations

Therapeutic efficacy of adoptive immunotherapy is predicated on in vivo antigen-specific proliferation of donor T cells

Kjaergaard, J., Peng, L., Cohen, P. A. & Shu, S., Jul 1 2003, In : Clinical Immunology. 108, 1, p. 8-20 13 p.

Research output: Contribution to journalArticle

18 Scopus citations
2002

Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14 + monocytes cultured under serum-free conditions

Lyakh, L. A., Koski, G. K., Young, H. A., Spence, S. E., Cohen, P. A. & Rice, N. R., Jan 15 2002, In : Blood. 99, 2, p. 600-608 9 p.

Research output: Contribution to journalArticle

39 Scopus citations