• 27577 Citations
  • 95 Scopus h-Index
1973 …2020

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2013

HDAC6 inhibition restores ciliary expression and decreases tumor growth

Gradilone, S. A., Radtke, B. N., Bogert, P. S., Huang, B. Q., Gajdos, G. B. & LaRusso, N. F., Apr 1 2013, In : Cancer research. 73, 7, p. 2259-2270 12 p.

Research output: Contribution to journalArticle

83 Scopus citations

Micro-computed tomography and nuclear magnetic resonance imaging for noninvasive, live-mouse cholangiography

Tabibian, J. H., MacUra, S. I., O'Hara, S. P., Fidler, J. L., Glockner, J. F., Takahashi, N., Lowe, V. J., Kemp, B. J., Mishra, P. K., Tietz, P. S., Splinter, P. L., Trussoni, C. E. & Larusso, N. F., Jun 1 2013, In : Laboratory Investigation. 93, 6, p. 733-743 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases

Masyuk, T. V., Radtke, B. N., Stroope, A. J., Banales, J. M., Gradilone, S. A., Huang, B., Masyuk, A. I., Hogan, M. C., Torres, V. E. & Larusso, N. F., Jul 1 2013, In : Hepatology. 58, 1, p. 409-421 13 p.

Research output: Contribution to journalArticle

63 Scopus citations

Physiology of cholangiocytes

Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P. & LaRusso, N. F., Jul 2 2013, In : Comprehensive Physiology. 3, 1, p. 541-565 25 p.

Research output: Contribution to journalArticle

86 Scopus citations

Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense

Hu, G., Gong, A. Y., Roth, A. L., Huang, B. Q., Ward, H. D., Zhu, G., LaRusso, N. F., Hanson, N. D. & Chen, X. M., Apr 1 2013, In : PLoS pathogens. 9, 4, e1003261.

Research output: Contribution to journalArticle

85 Scopus citations

Role for Krüppel-Like Transcription Factor 11 in Mesenchymal Cell Function and Fibrosis

Mathison, A., Grzenda, A., Lomberk, G., Velez, G., Buttar, N., Tietz, P., Hendrickson, H., Liebl, A., Xiong, Y. Y., Gores, G., Fernandez-Zapico, M., LaRusso, N. F., Faubion, W., Shah, V. H. & Urrutia, R., Sep 16 2013, In : PloS one. 8, 9, e75311.

Research output: Contribution to journalArticle

18 Scopus citations

Successful implementation of a telemedicine-based counseling program for high-risk patients with breast cancer

Pruthi, S., Stange, K. J., Malagrino, G. D., Chawla, K. S., LaRusso, N. F. & Kaur, J. S., Jan 2013, In : Mayo Clinic proceedings. 88, 1, p. 68-73 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

The zebrafish as a model to study polycystic liver disease

Tietz Bogert, P. S., Huang, B. Q., Gradilone, S. A., Masyuk, T. V., Moulder, G. L., Ekker, S. C. & Larusso, N. F., Jun 1 2013, In : Zebrafish. 10, 2, p. 211-217 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2012

Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease

Masyuk, T. V., Radtke, B. N., Stroope, A. J., Banales, J. M., Masyuk, A. I., Gradilone, S. A., Gajdos, G. B., Chandok, N., Bakeberg, J. L., Ward, C. J., Ritman, E. L., Kiyokawa, H. & Larusso, N. F., Mar 2012, In : Gastroenterology. 142, 3, p. 622-633.e4

Research output: Contribution to journalArticle

27 Scopus citations

Insignificant effect of secretin in rodent models of polycystic kidney and liver disease

Wang, X., Ye, H., Ward, C. J., Chu, J. Y. S., Masyuk, T. V., Larusso, N. F., Harris, P. C., Chow, B. K. C. & Torres, V. E., Jan 1 2012, In : American Journal of Physiology - Renal Physiology. 303, 7, p. F1089-F1098

Research output: Contribution to journalArticle

11 Scopus citations

Somatostatin analog therapy for severe polycystic liver disease: Results after 2 years

Hogan, M. C., Masyuk, T. V., Page, L., Holmes, D. R., Li, X., Bergstralh, E. J., Irazabal, M. V., Kim, B., King, B. F., Glockner, J. F., Larusso, N. F. & Torres, V. E., Sep 1 2012, In : Nephrology Dialysis Transplantation. 27, 9, p. 3532-3539 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Up-regulation of microRNA 506 leads to decreased Cl -/HCO 3 - anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis

Banales, J. M., Sáez, E., Úriz, M., Sarvide, S., Urribarri, A. D., Splinter, P., Tietz Bogert, P. S., Bujanda, L., Prieto, J., Medina, J. F. & Larusso, N. F., Aug 1 2012, In : Hepatology. 56, 2, p. 687-697 11 p.

Research output: Contribution to journalArticle

123 Scopus citations
2011

Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive MicroRNAs

Huebert, R. C., Jagavelu, K., Hendrickson, H. I., Vasdev, M. M., Arab, J. P., Splinter, P. L., Trussoni, C. E., Larusso, N. F. & Shah, V. H., Oct 1 2011, In : American Journal of Pathology. 179, 4, p. 1851-1860 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation

O'Hara, S. P., Splinter, P. L., Trussoni, C. E., Gajdos, G. B., Lineswala, P. N. & LaRusso, N. F., Sep 2 2011, In : Journal of Biological Chemistry. 286, 35, p. 30352-30360 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Epidermal growth factor protects the apical junctional complexes from hydrogen peroxide in bile duct epithelium

Guntaka, S. R., Samak, G., Seth, A., Larusso, N. F. & Rao, R., Sep 1 2011, In : Laboratory Investigation. 91, 9, p. 1396-1409 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Health reform: A community experience using design research as a guide

Severson, M. A., Wood, D. L., Chastain, C. N., Lee, L. G., Rees, A. C., Agerter, D. C., Holtz, C. P., Broers, J. K., Savoleinen, K. H., Spurrier, B. R. & Larusso, N. F., Oct 2011, In : Mayo Clinic proceedings. 86, 10, p. 973-980 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Patients, cells, and organelles: The intersection of science and serendipity

Larusso, N. F., May 1 2011, In : Hepatology. 53, 5, p. 1417-1426 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

The role of cilia in the regulation of bile flow

Larusso, N. F. & Masyuk, T. V., Jun 1 2011, In : Digestive Diseases. 29, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

TLR4 promotes cryptosporidium parvum clearance in a mouse model of biliary cryptosporidiosis

O'Hara, S. P., Tietz Bogert, P. S., Trussoni, C. E., Chen, X. & Larusso, N. F., Oct 1 2011, In : Journal of Parasitology. 97, 5, p. 813-821 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
2010

Activation of Trpv4 Reduces the Hyperproliferative Phenotype of Cystic Cholangiocytes From an Animal Model of ARPKD

Gradilone, S. A., Masyuk, T. V., Huang, B. Q., Banales, J. M., Lehmann, G. L., Radtke, B. N., Stroope, A., Masyuk, A. I., Splinter, P. L. & LaRusso, N. F., Jul 2010, In : Gastroenterology. 139, 1, p. 304-314.e2

Research output: Contribution to journalArticle

60 Scopus citations

Aquaporin-1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis

Huebert, R. C., Vasdev, M. M., Shergill, U., Das, A., Huang, B. Q., Charlton, M. R., LaRusso, N. F. & Shah, V. H., Jul 1 2010, In : Hepatology. 52, 1, p. 238-248 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia

Masyuk, A. I., Huang, B. Q., Ward, C. J., Gradilone, S. A., Banales, J. M., Masyuk, T. V., Radtke, B., Splinter, P. L. & LaRusso, N. F., Oct 1 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 4, p. G990-G999

Research output: Contribution to journalArticle

148 Scopus citations

Cholangiocyte myosin IIB is required for localized aggregation of sodium glucose cotransporter 1 to sites of Cryptosporidium parvum cellular invasion and facilitates parasite internalization

O'Hara, S. P., Gajdos, G. B., Trussoni, C. E., Splinter, P. L. & LaRusso, N. F., Jul 1 2010, In : Infection and Immunity. 78, 7, p. 2927-2936 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Hepato-renal pathology in Pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease

Stroope, A., Radtke, B., Huang, B., Masyuk, T., Torres, V., Ritman, E. & LaRusso, N., Mar 2010, In : American Journal of Pathology. 176, 3, p. 1282-1291 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Immortalized liver endothelial cells: A cell culture model for studies of motility and angiogenesis

Huebert, R. C., Jagavelu, K., Liebl, A. F., Huang, B. Q., Splinter, P. L., Larusso, N. F., Urrutia, R. A. & Shah, V. H., Dec 1 2010, In : Laboratory Investigation. 90, 12, p. 1770-1781 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

NFκB p50-CCAAT/enhancer-binding protein β (C/EBPβ)-mediated transcriptional repression of microRNA let-7i following microbial infection

O'Hara, S. P., Splinter, P. L., Gajdos, G. B., Trussoni, C. E., Fernandez-Zapico, M. E., Chen, X. M. & LaRusso, N. F., Jan 1 2010, In : Journal of Biological Chemistry. 285, 1, p. 216-225 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

Opisthorchis viverrini excretory/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte

Ninlawan, K., O'Hara, S. P., Splinter, P. L., Yongvanit, P., Kaewkes, S., Surapaitoon, A., LaRusso, N. F. & Sripa, B., Dec 1 2010, In : Parasitology International. 59, 4, p. 616-621 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and liver disease

Hogan, M. C., Masyuk, T. V., Page, L. J., Kubly, V. J., Bergstralh, E. J., Li, X., Kim, B., King, B. F., Glockner, J., Holmes, D. R., Rossetti, S., Harris, P. C., LaRusso, N. F. & Torres, V. E., Jun 1 2010, In : Journal of the American Society of Nephrology. 21, 6, p. 1052-1061 10 p.

Research output: Contribution to journalArticle

224 Scopus citations
2009

Characterization of PKD protein-positive exosome-like vesicles

Hogan, M. C., Manganelli, L., Woollard, J. R., Masyuk, A. I., Masyuk, T. V., Tammachote, R., Huang, B. Q., Leontovich, A. A., Beito, T. G., Madden, B. J., Charlesworth, M. C., Torres, V. E., Larusso, N. F., Harris, P. C. & Ward, C. J., Feb 1 2009, In : Journal of the American Society of Nephrology. 20, 2, p. 278-288 11 p.

Research output: Contribution to journalArticle

195 Scopus citations

HIV-1 tat protein suppresses cholangiocyte toll- like receptor 4 expression and defense against cryptosporidium parvum

O'Hara, S. P., Small, A. J., Gajdos, G. B., Badley, A. D., Chen, X. M. & LaRusso, N. F., Apr 15 2009, In : Journal of Infectious Diseases. 199, 8, p. 1195-1204 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Isolation of primary cilia for morphological analysis.

Huang, B., Masyuk, T. & LaRusso, N., 2009, In : Methods in cell biology. 94, p. 103-115 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3

Selaru, F. M., Olaru, A. V., Kan, T., David, S., Cheng, Y., Mori, Y., Yang, J., Paun, B., Jin, Z., Agarwal, R., Hamilton, J. P., Abraham, J., Georgiades, C., Alvarez, H., Vivekanandan, P., Yu, W., Maitra, A., Torbenson, M., Thuluvath, P. J., Gores, G. J. & 3 others, LaRusso, N. F., Hruban, R. & Meltzer, S. J., May 1 2009, In : Hepatology. 49, 5, p. 1595-1601 7 p.

Research output: Contribution to journalArticle

208 Scopus citations

MicroRNA-513 regulates B7-H1 translation and is involved in IFN-γ-induced B7-H1 expression in cholangiocytes

Gong, A. Y., Zhou, R., Hu, G., Li, X., Splinter, P. L., O'Hara, S. P., LaRusso, N. F., Soukup, G. A., Dong, H. & Chen, X. M., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1325-1333 9 p.

Research output: Contribution to journalArticle

131 Scopus citations

MicroRNAs: Key Modulators of Posttranscriptional Gene Expression

O'Hara, S. P., Mott, J. L., Splinter, P. L., Gores, G. J. & LaRusso, N. F., Jan 2009, In : Gastroenterology. 136, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

The application of design principles to innovate clinical care delivery.

Brennan, M. D., Duncan, A. K., Armbruster, R. R., Montori, V. M., Feyereisn, W. L. & LaRusso, N. F., Jan 1 2009, In : Journal for healthcare quality : official publication of the National Association for Healthcare Quality. 31, 1, p. 5-9 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD)

Banales, J. M., Masyuk, T. V., Gradilone, S. A., Masyuk, A. I., Medina, J. F. & LaRusso, N. F., Mar 9 2009, In : Hepatology. 49, 1, p. 160-174 15 p.

Research output: Contribution to journalArticle

83 Scopus citations
2008

Cholangiocyte bile salt transporters in cholesterol gallstone-susceptible and resistant inbred mouse strains

Liu, J. J., Glickman, J. N., Masyuk, A. I. & LaRusso, N. F., Oct 2008, In : Journal of Gastroenterology and Hepatology (Australia). 23, 10, p. 1596-1602 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors

Masyuk, A. I., Gradilone, S. A., Banales, J. M., Huang, B. Q., Masyuk, T. V., Lee, S. O., Splinter, P. L., Stroope, A. J. & LaRusso, N. F., Oct 1 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 4, p. G725-G734

Research output: Contribution to journalArticle

109 Scopus citations

Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease

Banales, J. M., Masyuk, T. V., Bogert, P. S., Huang, B. Q., Gradilone, S. A., Lee, S. O., Stroope, A. J., Masyuk, A. I., Medina, J. F. & LaRusso, N. F., Dec 2008, In : American Journal of Pathology. 173, 6, p. 1637-1646 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Host cell actin remodeling in response to cryptosporidium

O’Hara, S. P., Small, A. J., Chen, X. M. & Larusso, N. F., Jan 1 2008, In : Sub-cellular biochemistry. 47, p. 92-100 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease

Lee, S. O., Masyuk, T., Splinter, P., Banales, J. M., Masyuk, A., Stroope, A. & LaRusso, N., Nov 3 2008, In : Journal of Clinical Investigation. 118, 11, p. 3714-3724 11 p.

Research output: Contribution to journalArticle

126 Scopus citations

Pathobiology of biliary epithelia and cholangiocarcinoma: Proceedings of the Henry M. and Lillian Stratton Basic Research Single-Topic Conference

Sirica, A. E., Nathanson, M. H., Gores, G. J. & LaRusso, N. F., Dec 1 2008, In : Hepatology. 48, 6, p. 2040-2046 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Principles to promote physician satisfaction and work-life balance.

Shanafelt, T. D., West, C. P., Poland, G. A., LaRusso, N. F., Menaker, R. & Bahn, R. S., Dec 2008, In : Minnesota medicine. 91, 12, p. 41-43 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

The AGA Institute: A Professional Society With a Social Conscience

LaRusso, N. F., Dec 2008, In : Gastroenterology. 135, 6, p. e12-e13

Research output: Contribution to journalArticle

2007

{A figure is presented}The Utility of Lens Culinaris Agglutinin-Reactive α-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma: Evaluation in a United States Referral Population

Leerapun, A., Suravarapu, S. V., Bida, J. P., Clark, R. J., Sanders, E. L., Mettler, T. A., Stadheim, L. M., Aderca, I., Moser, C. D., Nagorney, D. M., LaRusso, N. F., de Groen, P. C., Menon, K. V. N., Lazaridis, K. N., Gores, G. J., Charlton, M. R., Roberts, R. O., Therneau, T. M., Katzmann, J. A. & Roberts, L. R., Mar 1 2007, In : Clinical Gastroenterology and Hepatology. 5, 3, p. 394-402 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

A cellular micro-RNA, let-7i, regulates toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection

Chen, X. M., Splinter, P. L., O'Hara, S. P. & LaRusso, N. F., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28929-28938 10 p.

Research output: Contribution to journalArticle

336 Scopus citations

A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation

Woollard, J. R., Punyashtiti, R., Richardson, S., Masyuk, T. V., Whelan, S., Huang, B. Q., Lager, D. J., Vandeursen, J., Torres, V. E., Gattone, V. H., Larusso, N. F., Harris, P. C. & Ward, C. J., Aug 1 2007, In : Kidney international. 72, 3, p. 328-336 9 p.

Research output: Contribution to journalArticle

68 Scopus citations

Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion

Gradilone, S. A., Masyuk, A. I., Splinter, P. L., Banales, J. M., Huang, B. Q., Tietz, P. S., Masyuk, T. V. & LaRusso, N. F., Nov 27 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 48, p. 19138-19143 6 p.

Research output: Contribution to journalArticle

132 Scopus citations

Cyclic AMP Regulates Bicarbonate Secretion in Cholangiocytes Through Release of ATP Into Bile

Minagawa, N., Nagata, J., Shibao, K., Masyuk, A. I., Gomes, D. A., Rodrigues, M. A., Lesage, G., Akiba, Y., Kaunitz, J. D., Ehrlich, B. E., Larusso, N. F. & Nathanson, M. H., Nov 2007, In : Gastroenterology. 133, 5, p. 1592-1602 11 p.

Research output: Contribution to journalArticle

93 Scopus citations
25 Scopus citations